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Connective Disease and Crohn's Disease

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https://www.readbyqxmd.com/read/28203422/colobronchial-fistula-the-pathogenesis-clinical-presentations-diagnosis-and-treatment
#1
Jinbo Zhao, Nan Ma, Zhengwei Zhao, Jie Lei, Qiang Lu, Feng Tian, Yongan Zhou, Yong Han, Xiaofei Li
BACKGROUND: Colobronchial fistula (CBF) is rare and easy to be delayed in clinic. There is no systemic study about this disease. The pathogenesis, clinical presentations, diagnosis and treatment of CBF were analyzed in this study. METHODS: The clinical data from 37 cases of CBF, which included one case in our institute and the other 36 cases in literature from January 1960 to August 2016, were reviewed and analyzed. The etiology, clinical presentations, diagnostic and therapeutic methods, and outcomes were summarized...
January 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28172582/p701-late-onset-crohn-s-disease-is-associated-with-high-risk-of-intestinal-perforation-and-low-risk-of-perianal-fistula-as-compared-with-early-onset-crohn-s-disease-the-connect-cohort
#2
H M Kim, H-S Kim, J S Kim, Y S Kim, J H Cheon, B D Ye, Y H Kim, D S Han
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28161704/serum-derived-hyaluronan-associated-protein-is-a-novel-biomarker-for-inflammatory-bowel-diseases
#3
Yoshiharu Yamaguchi, Hisatsugu Noda, Noriko Okaniwa, Kazunori Adachi, Tetsuya Shinmura, Shoko Nakagawa, Masahide Ebi, Naotaka Ogasawara, Yasushi Funaki, Lisheng Zhuo, Koji Kimata, Makoto Sasaki, Kunio Kasugai
BACKGROUND/AIMS: We evaluated the role of serum-derived hyaluronan-associated protein (SHAP) in inflammatory bowel disease (IBD) pathogenesis and its potential as a novel IBD biomarker. METHODS: We studied the SHAP expression in a mouse model of colitis and in human intestinal samples of IBD and compared serum concentrations with normal controls. RESULTS: SHAP was expressed in the connective tissue derived from inflamed regions of the intestine...
February 4, 2017: Digestion
https://www.readbyqxmd.com/read/28077249/altered-mucosal-expression-of-micrornas-in-pediatric-patients-with-inflammatory-bowel-disease
#4
Nóra Judit Béres, Zoltán Kiss, Zsófia Sztupinszki, Gábor Lendvai, András Arató, Erna Sziksz, Ádám Vannay, Attila J Szabó, Katalin Eszter Müller, Áron Cseh, Kriszta Boros, Gábor Veres
INTRODUCTION: MicroRNAs (miRs) came recently into focus as promising novel research targets offering new insights into the pathogenesis of inflammatory bowel diseases (IBD). AIMS: The aim of our study was to identify a pediatric IBD (pIBD) characteristic miR profile serving as potential Crohn's disease (CD) and ulcerative colitis (UC) specific diagnostic pattern and to further analyze the related target genes. METHODS: Small RNA sequencing was performed on inflamed and intact colonic biopsies of CD, and control patients...
December 27, 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28000249/amicrobial-pustulosis-of-the-folds-report-of-4-cases
#5
Michael Z Wang, Michael J Camilleri, Ruifeng Guo, Carilyn N Wieland
Amicrobial pustulosis of the folds (APF) is a rare disease characterized by aseptic pustular lesions involving cutaneous folds, typically occurring in the context of an autoimmune disorder. We present 4 patients with APF, focusing on clinical and histopathologic characteristics to improve the recognition of this entity. All 4 patients had intertriginous and extra-intertriginous involvement. Common histopathologic features of skin biopsies in these patients were intracorneal, subcorneal, intraepidermal, perivascular, perifollicular and interstitial neutrophilic inflammation...
December 21, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27796880/telocytes-in-chronic-inflammatory-and-fibrotic-diseases
#6
Lidia Ibba-Manneschi, Irene Rosa, Mirko Manetti
Telocytes are a peculiar stromal (interstitial) cell type implicated in tissue homeostasis and development, as well as in the pathophysiology of several disorders. Severe damage and reduction of telocytes have been reported during fibrotic remodeling of multiple organs in various diseases, including scleroderma, Crohn's disease, ulcerative colitis, and liver fibrosis, as well as in chronic inflammatory lesions like those of primary Sjögren's syndrome and psoriasis. Owing to their close relationship with stem cells, telocytes are also supposed to contribute to tissue repair/regeneration...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27760077/the-gut-microbiome-of-pediatric-crohn-s-disease-patients-differs-from-healthy-controls-in-genes-that-can-influence-the-balance-between-a-healthy-and-dysregulated-immune-response
#7
Katherine A Dunn, Jessica Moore-Connors, Brad MacIntyre, Andrew Stadnyk, Nikhil A Thomas, Angela Noble, Gamal Mahdi, Mohsin Rashid, Anthony R Otley, Joseph P Bielawski, Johan Van Limbergen
BACKGROUND: Exclusive enteral nutrition (EEN) is a first-line therapy in pediatric Crohn's disease (CD) thought to induce remission through changes in the gut microbiome. With microbiome assessment largely focused on microbial taxonomy and diversity, it remains unclear to what extent EEN induces functional changes that thereby contribute to its therapeutic effect. METHODS: Fecal samples were collected from 15 pediatric CD patients prior to and after EEN treatment, as well as from 5 healthy controls...
November 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27755272/inflammatory-bowel-disease-ibd-connect-a-novel-volunteer-program-for-hospitalized-patients-with-ibd-and-their-families
#8
Jana G Hashash, Randi Sigal, Pamela Wein-Levy, Eva M Szigethy, Joy J Merusi, Miguel D Regueiro
Patients with inflammatory Bowel Disease (IBD) often require hospitalization and this experience is stressful. Health care providers frequently do not have adequate time to address the emotional impact of the hospitalization on the patient and family. Nonmedical support for inpatients was identified as an unmet need by a Crohn's disease patient's family. This led to the development of a volunteer peer specialist network, IBD Connect, where peer volunteers visit hospitalized patients with IBD to offer emotional support and educational materials...
November 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27717092/the-autoimmunity-oral-microbiome-connection
#9
N Nikitakis, W Papaioannou, L I Sakkas, E Kousvelari
To date there is a major effort in deciphering the role of complex microbial communities, especially the oral and gut microbiomes, in the pathogenesis of various diseases. Increasing evidence indicates a key role for the oral microbiome in autoimmune diseases. In this review article, we discuss links of the oral microbiota to a group of autoimmune diseases, i.e., Sjögren's syndrome (SS), systemic lupus erythematosus (SLE), Crohn's disease (CD), and rheumatoid arthritis (RA). We particularly focus on factors that affect the balance between the immune system and the composition of microbiota leading to dysbiosis, loss of tolerance and subsequent autoimmune disease progression and maintenance...
October 7, 2016: Oral Diseases
https://www.readbyqxmd.com/read/27609333/urine-metabolome-profiling-of-immune-mediated-inflammatory-diseases
#10
Arnald Alonso, Antonio Julià, Maria Vinaixa, Eugeni Domènech, Antonio Fernández-Nebro, Juan D Cañete, Carlos Ferrándiz, Jesús Tornero, Javier P Gisbert, Pilar Nos, Ana Gutiérrez Casbas, Lluís Puig, Isidoro González-Álvaro, José A Pinto-Tasende, Ricardo Blanco, Miguel A Rodríguez, Antoni Beltran, Xavier Correig, Sara Marsal
BACKGROUND: Immune-mediated inflammatory diseases (IMIDs) are a group of complex and prevalent diseases where disease diagnostic and activity monitoring is highly challenging. The determination of the metabolite profiles of biological samples is becoming a powerful approach to identify new biomarkers of clinical utility. In order to identify new metabolite biomarkers of diagnosis and disease activity, we have performed the first large-scale profiling of the urine metabolome of the six most prevalent IMIDs: rheumatoid arthritis, psoriatic arthritis, psoriasis, systemic lupus erythematosus, Crohn's disease, and ulcerative colitis...
September 8, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27548430/the-search-for-causative-environmental-factors-in-inflammatory-bowel-disease
#11
Gerhard Rogler, Jonas Zeitz, Luc Biedermann
Inflammatory bowel disease (IBD) has become a 'prototype disease' for chronic auto-inflammatory disorders with a polygenic background and important multifaceted environmental trigger components. The environmental factors contribute both to pathogenesis and disease flares. Thus, IBD is a disease par excellence to study the interactions between host genetics, environmental factors (such as infections or smoking) and 'in-vironmental' factors - for example, our intestinal microbiota. Longitudinal intercurrent events, including the impact of long-term medication on disease progression or stabilization, can exemplarily be studied in this disease group...
2016: Digestive Diseases
https://www.readbyqxmd.com/read/27531998/mucosal-interactions-between-genetics-diet-and-microbiome-in-inflammatory-bowel-disease
#12
REVIEW
Abigail Basson, Ashley Trotter, Alex Rodriguez-Palacios, Fabio Cominelli
Numerous reviews have discussed gut microbiota composition changes during inflammatory bowel diseases (IBD), particularly Crohn's disease (CD). However, most studies address the observed effects by focusing on studying the univariate connection between disease and dietary-induced alterations to gut microbiota composition. The possibility that these effects may reflect a number of other interconnected (i.e., pantropic) mechanisms, activated in parallel, particularly concerning various bacterial metabolites, is in the process of being elucidated...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27459267/association-of-inflammatory-bowel-disease-with-ankylosing-spondylitis-and-rheumatoid-arthritis-a-nationwide-population-based-study
#13
Jung Min Bae, Ji Yoon Choo, Ki-Jo Kim, Kyung-Su Park
OBJECTIVES: Tantalizing connections between autoimmune rheumatic diseases (ARDs) and inflammatory bowel disease (IBD) have become evident with regard to their genetic and immunologic background. However, the association between these two disease entities remains unclear. The aim of this study is to investigate the association between each ARD and IBD. METHODS: A nationwide population-based cross-sectional study was performed using the Korean National Health Insurance Claims database...
July 26, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27310096/rheumatologic-and-extraintestinal-manifestations-of-inflammatory-bowel-diseases
#14
Ripalta Colìa, Addolorata Corrado, Francesco Paolo Cantatore
Inflammatory bowel diseases (IBDs) often present as a complex inflammatory process wherein colon lesions (ulcerative colitis, UC) or widespread ulceration and fissure (Crohn's disease, CD) might be accompanied by ancillary extraintestinal manifestations (EIMs) that could involve almost every organ system, but also by autoimmune disorders ranging from psoriasis and rheumatoid arthritis to connective tissue diseases. Certain EIMs are more common related to the activity of the IBD (joint, skin, ocular and oral manifestations), other EIMs typically run a course independent of the IBD activity (hepatobiliary disorders) and some are non-specific disorders (osteoporosis and amyloidosis)...
June 16, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/27110308/osteoprotegerin-s-rankl-and-selected-interleukins-in-the-pathology-of-bone-metabolism-in-patients-with-crohn-s-disease
#15
Iwona Krela-Kaźmierczak, Ewa Wysocka, Aleksandra Szymczak, Piotr Eder, Michał Michalak, Liliana Łykowska-Szuber, Kamila Stawczyk-Eder, Katarzyna Klimczak, Krzysztof Linke, Wanda Horst-Sikorska
INTRODUCTION: Crohn's disease (CD) promotes the development of osteopaenia/osteoporosis, the cytokine background of which is not fully known. AIM: Evaluation of bone mineral density (BMD), the prevalence of osteopaenia and osteoporosis, and the determination of the levels of selected interleukins (IL), osteoprotegerin (OPG), and s-RANKL proteins in patients with CD in relation to a control group and assessment of the relationship between the tested cytokines, OPG, s-RANKL, and BMD...
2016: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/27021506/disease-phenotype-activity-and-clinical-course-prediction-based-on-c-reactive-protein-levels-at-diagnosis-in-patients-with-crohn-s-disease-results-from-the-connect-study
#16
Jee Hye Kwon, Jong Pil Im, Byong Duk Ye, Jae Hee Cheon, Hyun Joo Jang, Kang Moon Lee, You Sun Kim, Sang Wook Kim, Young Ho Kim, Geun Am Song, Dong Soo Han, Won Ho Kim, Joo Sung Kim
BACKGROUND/AIMS: C-reactive protein (CRP) is an easily measured index of disease activity, but its ability to predict clinical course is controversial. We therefore designed a study to determine whether the CRP level at Crohn's disease (CD) diagnosis is a valuable indicator of the disease phenotype, activity, and clinical course. METHODS: We retrospectively analyzed 705 CD patients from 32 institutions. The patients were classified into two groups according to CRP level...
July 15, 2016: Gut and Liver
https://www.readbyqxmd.com/read/27016400/concise-review-cellular-therapies-the-potential-to-regenerate-and-restore-tolerance-in-immune-mediated-intestinal-diseases
#17
Rachele Ciccocioppo, Giuseppina Cristina Cangemi, Peter Kruzliak, Gino Roberto Corazza
Chronic inflammatory enteropathies, including celiac disease, Crohn's disease, and ulcerative colitis, are lifelong disabling conditions whose cure is still an unmet need, despite the great strides made in understanding their complex pathogenesis. The advent of cellular therapies, mainly based on the use of stem cells, represents a great step forward thanks to their multitarget strategy. Both hematopoietic stem cells (HSC) and mesenchymal stem/stromal cells (MSC) have been employed in the treatment of refractory cases with promising results...
June 2016: Stem Cells
https://www.readbyqxmd.com/read/26968111/trafficking-of-antigens-from-gut-to-sacroiliac-joints-and-spine-in-reactive-arthritis-and-spondyloarthropathies-mainly-through-lymphatics
#18
Jean-Marie Berthelot, Pascal Claudepierre
Bacterial trafficking from gut to mesenteric lymph nodes is physiologic only for a few commensal species, like Alcaligenes which produces antimicrobial-substances inhibiting growth of pathogenic bacteria. In reactive arthritis, some living bacteria transiently manage to travel from gut to joints/enthesis within dendritic cells and/or macrophages. Migration of dead or dormant bacteria outside the gut in spondyloarthropathies, including those associated with Crohn's disease, can occur either through blood or lymphatics...
October 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/26880890/treatment-with-a-monoclonal-anti-il-12p40-antibody-induces-substantial-gut-microbiota-changes-in-an-experimental-colitis-model
#19
Josué Castro-Mejía, Maja Jakesevic, Łukasz Krych, Dennis S Nielsen, Lars H Hansen, Bodil C Sondergaard, Peter H Kvist, Axel K Hansen, Thomas L Holm
Background and Aim. Crohn's disease is associated with gut microbiota (GM) dysbiosis. Treatment with the anti-IL-12p40 monoclonal antibody (12p40-mAb) has therapeutic effect in Crohn's disease patients. This study addresses whether a 12p40-mAb treatment influences gut microbiota (GM) composition in mice with adoptive transfer colitis (AdTr-colitis). Methods. AdTr-colitis mice were treated with 12p40-mAb or rat-IgG2a or NaCl from days 21 to 47. Disease was monitored by changes in body weight, stool, endoscopic and histopathology scores, immunohistochemistry, and colonic cytokine/chemokine profiles...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/26855817/influence-of-environmental-factors-in-the-development-of-inflammatory-bowel-diseases
#20
REVIEW
Evangelia Legaki, Maria Gazouli
Idiopathic inflammatory bowel diseases (IBD), Crohn's disease (CD) and ulcerative colitis (UC), are multifactorial diseases that are manifested after disruption of a genetic predisposed individual and its intestinal microflora through an environmental stimulus. Urbanization and industrialization are associated with IBD. Epidemiological data, clinical observations and family/immigrants studies indicate the significance of environmental influence in the development of IBD. Some environmental factors have a different effect on the subtypes of IBD...
February 6, 2016: World Journal of Gastrointestinal Pharmacology and Therapeutics
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