keyword
MENU ▼
Read by QxMD icon Read
search

Complications of Crohn's Disease

keyword
https://www.readbyqxmd.com/read/28105752/exclusive-enteral-nutrition-provides-an-effective-bridge-to-safer-interval-elective-surgery-for-adults-with-crohn-s-disease
#1
N Heerasing, B Thompson, P Hendy, G A Heap, G Walker, R Bethune, S Mansfield, C Calvert, N A Kennedy, T Ahmad, J R Goodhand
BACKGROUND: Few studies have reported the systematic use of exclusive enteral nutrition in the perioperative setting. AIMS: To test the hypothesis that exclusive enteral nutrition provides a safe and effective bridge to surgery and reduces post-operative complications, in adult patients with Crohn's disease requiring urgent surgery for stricturing or penetrating complications. METHODS: Patients treated with exclusive enteral nutrition prior to surgery were each matched with two control patients for disease behaviour, type of surgery, age at diagnosis and disease duration...
January 20, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28105620/-effect-of-a-clinical-pathway-in-patients-with-crohn-s-disease-complicated-with-intestinal-obstruction
#2
Zhen Guo, Lei Cao, Jianfeng Gong, Yi Li, Lili Gu, Weiming Zhu, Jieshou Li
OBJECTIVE: To evaluate the effect of a clinical pathway for Crohn disease (CD) complicated with intestinal obstruction. METHODS: CD patients complicated with intestinal obstruction in Inflammatory Bowel Disease(IBD) Center of Jinling Hospital were enrolled. One hundred and nineteen CD patients from March 2014 to September 2015 received treatment with the clinical pathway (CP), which was developed based on medical evidence and experience of the IBD center in February 2014, as CP group...
January 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28105618/-efficacy-analysis-of-fecal-microbiota-transplantation-in-the-treatment-of-406-cases-with-gastrointestinal-disorders
#3
Ning Li, Hongliang Tian, Chunlian Ma, Chao Ding, Xiaolong Ge, Lili Gu, Xuelei Zhang, Bo Yang, Yue Hua, Yifan Zhu, Yan Zhou
OBJECTIVE: To evaluate the efficacy and safety of fecal microbiota transplantation (FMT) for gastrointestinal disorders. METHODS: Retrospective analysis of the clinical data of 406 patients who underwent FMT from May 2014 to April 2016 in the Intestinal Microenvironment Treatment Centre of Nanjing General Hospital was performed, including patients with constipation(276 cases), recurrent Clostridium Difficile infection (RCDI, 61 cases), ulcerative colitis(44 cases), irritable bowel syndrome (15 cases) and Crohn's disease(10 cases)...
January 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28098059/laparoscopic-ileocecal-resection-in-acute-and-chronic-presentations-of-crohn-s-disease-a-single-center-experience
#4
G Cocorullo, R Tutino, N Falco, G Salamone, T Fontana, L Licari, G Gulotta
INTRODUCTION: The terminal ileum is the most involved tract in Crohn's disease. The obstruction in this location is the most frequent complication. Acute or chronic presentations can occur. Surgery finds a role in the management of chronic strictures and in acute clinical presentations with complications not improving with conservative therapy. PATIENTS AND METHODS: We investigate the outcome of patients with obstruction of the ileo-cecal bowel tract laparoscopically managed...
September 2017: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/28091846/risk-factors-of-surgical-site-infections-in-patients-with-crohn-s-disease-complicated-with-gastrointestinal-fistula
#5
Kun Guo, Jianan Ren, Guanwei Li, Qiongyuan Hu, Xiuwen Wu, Zhiwei Wang, Gefei Wang, Guosheng Gu, Huajian Ren, Zhiwu Hong, Jieshou Li
PURPOSE: Surgical site infection (SSI) is the most common complication following surgical procedures. This study aimed to determine risk factors associated with SSI in patients with Crohn's disease (CD) complicated with gastrointestinal fistula. METHODS: This was a retrospective review of patients who underwent surgical resection in gastrointestinal fistula patients with CD between January 2013 and January 2015, identified from a prospectively maintained gastrointestinal fistula database...
January 16, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28087156/french-national-consensus-clinical-guidelines-for-the-management-of-crohn-s-disease
#6
Laurent Peyrin-Biroulet, Yoram Bouhnik, Xavier Roblin, Guillaume Bonnaud, Hervé Hagège, Xavier Hébuterne
BACKGROUND: Crohn's disease (CD) is a chronic and disabling condition. There is no curative medical treatment but current treatments provide increasingly sustainable control of the disease and allow patients a better quality of life. There is limited evidence supporting CD management in specific clinical situations, thus precluding an evidence-based approach. AIMS: To help clinicians in making informed treatment decisions, a group of 59 French gastroenterologists with experience in the management of CD met to develop straightforward and practical algorithms based on the European Crohn's and Colitis Organisation (ECCO) recommendations...
December 22, 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28079626/complications-and-disease-recurrence-after-primary-ileocecal-resection-in-pediatric-crohn-s-disease-a-multicenter-cohort-analysis
#7
Kay Diederen, Lissy de Ridder, Patrick van Rheenen, Victorien M Wolters, Maria L Mearin, Gerard M Damen, Tim G de Meij, Herbert van Wering, Laura A Tseng, Matthijs W Oomen, Justin R de Jong, Cornelius E Sloots, Marc A Benninga, Angelika Kindermann
BACKGROUND: Studies on the outcome of ileocecal resection in pediatric Crohn's disease (CD) have a limited follow-up and fail to assign predictors of adverse outcomes. Therefore, we aimed to investigate (I) the complication and disease recurrence rates and (II) identify risk factors for these adverse outcomes after ileocecal resection for pediatric CD. METHODS: This is a retrospective cohort analysis of all children (<18 years) that underwent ileocecal resection as first intestinal resection for CD derived from 7 tertiary hospitals in the Netherlands (1990-2015)...
February 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28079620/clostridium-difficile-infection-and-risk-of-colectomy-in-patients-with-inflammatory-bowel-disease-a-bias-adjusted-meta-analysis
#8
Yingxi Chen, Luis Furuya-Kanamori, Suhail A Doi, Ashwin N Ananthakrishnan, Martyn Kirk
BACKGROUND: Clostridium difficile infection (CDI) is a common complication of inflammatory bowel diseases (IBDs) and is associated with worse outcome. Variable rates of colectomy have been reported among IBD complicated by CDI. We conducted a systematic review and meta-analysis of studies to assess the association between CDI and colectomy among patients with IBD. METHODS: The literature was systematically searched using PubMed from inception through April 2016...
February 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28068895/can-surgery-for-inflammatory-bowel-disease-be-personalized
#9
Antonino Spinelli, Alessandra Marano, Claudio Bacchelli, Nicolò Maria Mariani, Marco Montorsi, Paulo Gustavo Kotze
In the treatment of Inflammatory Bowel Diseases (IBD) despite advances in medical therapies, surgery has maintained a leading role in the management of complications of the disease, as well as in cases of failure of medical therapy. Surgery has become more and more minimally invasive, struggling for a difficult balance between guidelines and personalized treatment tailored on the single patient's need. In the present paper, the authors discuss the possible role for a personalization in debated fields of surgical treatment of Crohn&s disease and ulcerative colitis...
January 5, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28049025/correction-of-vitamin-d-deficiency-using-sublingually-administered-vitamin-d2-in-a-crohn-s-disease-patient-with-mal-absorption-and-a-new-ileostomy
#10
REVIEW
Patrick McCullough, Robert Heaney
Vitamin D deficiency has been shown to be associated with many adverse health problems. Studies have shown that patients with Crohn's disease who have low vitamin D levels have a poorer quality of life than those with more adequate levels. It has also been shown that patients with mal-absorption problems have a difficult time achieving normal vitamin D levels in spite of aggressive supplementation, and that exposure to UVB radiation may be the most effective treatment option for these patients. We present a case in which 25-hydroxyvitamin D levels were normalized within 2 weeks in a severely vitamin D deficient patient with Crohn's disease with mal-absorption and a new ileostomy, utilizing sublingually administered vitamin D2...
December 31, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28045769/diverting-ileostomy-for-the-treatment-of-severe-refractory-pediatric-inflammatory-bowel-disease
#11
Elizabeth C Maxwell, Noor Dawany, Robert N Baldassano, Petar Mamula, Peter Mattei, Lindsey Albenberg, Judith R Kelsen
OBJECTIVES: Diverting ileostomy is used as a temporizing therapy in patients with perianal Crohn disease; however, little data exist regarding its use for colonic disease. The primary aim of the present study was to determine the role of diversion in severe refractory colonic inflammatory bowel disease (IBD) in a pediatric population. METHODS: Retrospective study of patients who underwent diverting ileostomy at The Children's Hospital of Philadelphia from 2000 to 2014 for the management of severe, refractory colonic IBD...
December 30, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28041688/laparoscopic-surgical-treatment-of-ileocecal-crohn-s-disease-impact-of-obesity-on-short-term-results
#12
David Parés, Awad Shamali, Karen Flashman, Daniel O'Leary, Asha Senapati, John Conti, Amjad Parvaiz, Jim Khan
INTRODUCTION: The aim of our study was to analyse the short-term outcomes of laparoscopic surgery for a no medical responding ileocolic Cohn's disease in a single centre according to the presence of obesity. METHODS: A cross-sectional study was performed including all consecutive patients who underwent laparoscopic resection for ileocecal Crohn's disease from November 2006 to November 2015. Patients were divided according to body mass index ≥ 30 kg/m(2) in order to study influence of obesity in the short-term outcomes...
December 29, 2016: Cirugía Española
https://www.readbyqxmd.com/read/28002130/a-pooled-analysis-of-efficacy-safety-and-long-term-outcome-of-endoscopic-balloon-dilation-therapy-for-patients-with-stricturing-crohn-s-disease
#13
Dominik Bettenworth, Anders Gustavsson, Ashish Atreja, Rocio Lopez, Curt Tysk, Gert van Assche, Florian Rieder
BACKGROUND: Endoscopic balloon dilation (EBD) is widely used to manage Crohn's disease-associated strictures. However, most studies of the safety and efficacy are small and heterogenous. We performed a combined analysis of published studies and evaluated 676 comprehensive individual participant data sets to determine the overall effects of EBD. METHODS: Citations from the Embase, MEDLINE, and the Cochrane library from 1991 through 2013 were systematically reviewed, and references of cited articles were assessed for relevant publications...
January 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28000195/-risk-factors-of-early-surgical-intervention-in-crohn-s-disease-patients-with-spontaneous-intra-abdominal-abscess
#14
Xiaosheng He, Xiaobin Zheng, Lei Lian, Chi Zhou, Xiaowen He, Xiaojian Wu, Ping Lan
OBJECTIVE: To investigate the risk factors of early surgical intervention in Crohn's disease (CD) patients with spontaneous intra-abdominal abscess. METHODS: Clinical data of 94 CD patients with spontaneous intra-abdominal abscess admitted to The Sixth Affiliated Hospital of Sun Yat-sen University between May 2008 and Dec 2015 were analyzed retrospectively. Univariate and multivariate analysis were applied to evaluate the early surgery risk of CD patients with spontaneous intra-abdominal abscess using logistic regression model...
December 25, 2016: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27995633/infliximab-vs-adalimumab-in-crohn-s-disease-results-from-327-patients-in-an-australian-and-new-zealand-observational-cohort-study
#15
J D Doecke, F Hartnell, P Bampton, S Bell, G Mahy, Z Grover, P Lewindon, L V Jones, K Sewell, K Krishnaprasad, R Prosser, D Marr, J Fischer, G R Thomas, J V Tehan, N S Ding, S E Cooke, K Moss, A Sechi, P De Cruz, R Grafton, S J Connor, I C Lawrance, R B Gearry, J M Andrews, G L Radford-Smith
BACKGROUND: Maintenance anti-tumour necrosis factor-α (anti-TNFα) treatment for Crohn's disease is the standard of care for patients with an inadequate response to corticosteroids and immunomodulators. AIM: To compare the efficacy and safety of infliximab and adalimumab in clinical practice and assess the value of concomitant immunomodulator therapy. METHODS: We performed an observational cohort study in consecutive patients with Crohn's disease qualifying for anti-TNFα treatment in Australia and New Zealand between 2007 and 2011...
February 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27986839/optimisation-of-intestinal-fibrosis-and-survival-in-the-mouse-s-typhimurium-model-for-anti-fibrotic-drug-discovery-and-preclinical-applications
#16
Laura A Johnson, Eva S Rodansky, David S Moons, Scott D Larsen, Richard R Neubig, Peter D R Higgins
BACKGROUND AND AIMS: Intestinal fibrosis is a frequent complication in Crohn's disease [CD]. The mouse Salmonella typhimurium model, due to its simplicity, reproducibility, manipulability, and penetrance, is an established fibrosis model for drug discovery and preclinical trials. However, the severity of fibrosis and mortality are host- and bacterial strain-dependent, thus limiting the original model. We re-evaluated the S. typhimurium model to optimise fibrosis and survival, using commercially available mouse strains...
December 16, 2016: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/27986584/bariatric-surgery-in-morbidly-obese-patients-with-inflammatory-bowel-disease-a-systematic-review
#17
Saeed Shoar, Sayed Shahabuddin Hoseini, Mohammad Naderan, Habibollah Mahmoodzadeh, Fung Ying Man, Nasrin Shoar, Motahar Hosseini, Shahram Bagheri-Hariri
BACKGROUNDS: With increased prevalence of obesity, the number of inflammatory bowel disease (IBD) patients suffering from morbid obesity has raised. It is not clear yet if bariatric surgery is a safe and effective option in this population. OBJECTIVES: Our systematic review aims to summarize the available literature on the safety and efficacy of bariatric surgery in morbidly obese patients with IBD. SETTING: University hospital, Iran. METHODS: A PubMed/MEDLINE search was performed to identify studies reporting the outcome of morbidly obese IBD patients...
October 25, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/27981209/crohn-s-disease-fibroblasts-overproduce-the-novel-protein-kiaa1199-to-create-proinflammatory-hyaluronan-fragments
#18
Artin Soroosh, Sami Albeiroti, Gail A West, Belinda Willard, Claudio Fiocchi, Carol A de la Motte
BACKGROUND & AIMS: Crohn's Disease (CD) is a chronic inflammatory disease of the gastrointestinal tract. Fibrosis, a serious complication of CD, occurs when activated intestinal fibroblasts deposit excessive amounts of extracellular matrix (ECM) in affected areas. A major component of the ECM is high-molecular-weight hyaluronan (HA) that, when depolymerized to low-molecular-weight fragments, becomes proinflammatory and profibrotic. Mechanisms for HA degradation are incompletely understood, but the novel protein KIAA1199 recently was discovered to degrade HA...
May 2016: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27966058/surgical-considerations-in-the-treatment-of-small-bowel-crohn-s-disease
#19
Lillias Holmes Maguire, Karim Alavi, Ranjan Sudan, Paul E Wise, Andreas M Kaiser, Liliana Bordeianou
Surgery remains a cornerstone of the management of Crohn's disease (CD). Despite the rise of biologic therapy, most CD patients require surgery for penetrating, obstructing, or malignant complications. Optimal surgical therapy requires sophisticated operative judgment and medical optimization. Intraoperatively, surgeons must balance treatment of CD complications against bowel preservation and functional outcome. This demands mastery of multiple techniques for anastomosis and strictureplasty, accurate assessment of bowel integrity for margin minimization, and a comprehensive skillset for navigating adhesions and altered anatomy, controlling thickened mesentery, and safely managing the hostile abdomen...
December 13, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27958285/postoperative-complications-after-ileocecal-resection-in-crohn-s-disease-a-prospective-study-from-the-remind-group
#20
Mathurin Fumery, Philippe Seksik, Claire Auzolle, Nicolas Munoz-Bongrand, Jean-Marc Gornet, Gilles Boschetti, Eddy Cotte, Anthony Buisson, Anne Dubois, Benjamin Pariente, Philippe Zerbib, Najim Chafai, Carmen Stefanescu, Yves Panis, Philippe Marteau, Karine Pautrat, Charles Sabbagh, Jerome Filippi, Marc Chevrier, Pascal Houze, Xavier Jouven, Xavier Treton, Matthieu Allez
OBJECTIVES: We sought to determine the frequency of and risk factors for early (30-day) postoperative complications after ileocecal resection in a well-characterized, prospective cohort of Crohn's disease patients. METHODS: The REMIND group performed a nationwide study in 9 French university medical centers. Clinical-, biological-, surgical-, and treatment-related data on the 3 months before surgery were collected prospectively. Patients operated on between 1 September 2010 and 30 August 2014 were included...
December 13, 2016: American Journal of Gastroenterology
keyword
keyword
90122
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"