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https://www.readbyqxmd.com/read/28724279/alterations-in-striatal-circuits-underlying-addiction-like-behaviors
#1
REVIEW
Hyun Jin Kim, Joo Han Lee, Kyunghwa Yun, Joung-Hun Kim
Drug addiction is a severe psychiatric disorder characterized by the compulsive pursuit of drugs of abuse despite potential adverse consequences. Although several decades of studies have revealed that psychostimulant use can result in extensive alterations of neural circuits and physiology, no effective therapeutic strategies or medicines for drug addiction currently exist. Changes in neuronal connectivity and regulation occurring after repeated drug exposure contribute to addiction-like behaviors in animal models...
June 30, 2017: Molecules and Cells
https://www.readbyqxmd.com/read/28724260/pleuropterus-multiflorus-hasuo-mediated-straightforward-eco-friendly-synthesis-of-silver-gold-nanoparticles-and-evaluation-of-their-anti-cancer-activity-on-a549-lung-cancer-cell-line
#2
Verónica Castro-Aceituno, Ragavendran Abbai, Seong Soo Moon, Sungeun Ahn, Ramya Mathiyalagan, Yu-Jin Kim, Yeon-Ju Kim, Deok Chun Yang
Pleuropterus multiflorus (Hasuo) is a widely used medicinal plant in Korea and China for treating amnesia, isnomia, heart throbbing etc. With the constructive idea of promoting the wide-spread usage of P. multiflorus, we propose its indirect usage in the form of biologically active silver (Pm-AgNPs) and gold nanoparticles (Pm-AuNPs). The synthesized nanoparticles were predominantly spherical, crystalline with the Z-average hydrodynamic diameter of 274.8nm and 104.8nm respectively. Also, proteins and phenols were identified as the major players involved in their synthesis and stability...
July 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28724259/herbal-pre-conditioning-induces-proliferation-and-delays-senescence-in-wharton-s-jelly-mesenchymal-stem-cells
#3
Avinash Sanap, Bhawna Chandravanshi, Tejas Shah, Girish Tillu, Anand Dhanushkodi, Ramesh Bhonde, Kalpana Joshi
BACKGROUND: Mesenchymal Stem Cells (MSCs) are multipotent stem cells which are being explored for various clinical applications. Isolation and in-vitro expansion of MSCs remain important in achieving desired cell number for the therapy. However, in-vitro proliferation of MSCs is often associated with senescence and early onset of apoptosis which limits its therapeutic ability and long term clinical use. Tinospora cordifolia and Withania somnifera are used widely in Ayurveda: the traditional Indian system of medicine and are reported to have rejuvenating and anti-aging potential...
July 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28724199/antidiabetic-potential-in-vitro-inhibition-effects-of-some-natural-phenolic-compounds-on-%C3%AE-glycosidase-and-%C3%AE-amylase-enzymes
#4
Parham Taslimi, İlhami Gulçin
α-Glycosidase is a catalytic enzyme and it destroys the complex carbohydrates into simple absorbable sugar units. The natural phenolic compounds were tested for their antidiabetic properties as α-glycosidase and α-amylase inhibitors. The phenolic compounds investigated in this study have been used as antidiabetic common medicines. This paper aimed to consider their capability to inhibit α-amylase and α-glycosidase, two significant enzymes defined in serum glucose adjustment. These examination recorded impressive inhibition profiles with IC50 values in the range of 137...
July 19, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28724164/predictive-characteristics-of-elevated-1-hour-glucose-challenge-test-results-for-gestational-diabetes
#5
Alan T N Tita, Yinglei Lai, Mark B Landon, Susan M Ramin, Brian Casey, Ronald J Wapner, Michael W Varner, John M Thorp, Anthony Sciscione, Patrick Catalano, Margaret Harper, George R Saade, Steve N Caritis, Yoram Sorokin, Alan M Peaceman, Jorge E Tolosa
No abstract text is available yet for this article.
July 19, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28724158/the-inner-physician-why-and-how-to-practise-big-picture-medicine
#6
Jeffrey M Ring
No abstract text is available yet for this article.
July 2017: Family Medicine
https://www.readbyqxmd.com/read/28724155/a-family-systems-curriculum-back-to-the-future
#7
Rebekah Schiefer, Alexandra Verdieck Devlaeminck, Holly Hofkamp, Sheldon Levy, Demetrio Sanchez, John Muench
BACKGROUND AND OBJECTIVES: Although both residents and teaching faculty endorse its value, a recent review of family medicine residency programs confirms minimal formal family systems theory training. We consider the historical context of family systems training in family medicine and other competing priorities in practice and residency curricula. METHODS: We developed a longitudinal family systems curriculum, delivered in the third year of a 4-year residency program, and evaluated 2 years of the program using scales to assess self-reported confidence, knowledge and skills...
July 2017: Family Medicine
https://www.readbyqxmd.com/read/28724154/mapping-residency-global-health-experiences-to-the-acgme-family-medicine-milestones
#8
Maureen O Grissom, Tochi Iroku-Malize, Rita Peila, Marco Perez, Neubert Philippe
BACKGROUND AND OBJECTIVES: Global health (GH) experiences are a unique part of family medicine (FM) training that offer an opportunity for residents to demonstrate development across a multitude of the milestones recently implemented by the Accreditation Council for Graduate Medical Education (ACGME). The GH experience presents an opportunity for resident development, and including a component of written reflection can provide tangible evidence of development in areas that can be difficult to assess...
July 2017: Family Medicine
https://www.readbyqxmd.com/read/28724152/cost-of-incremental-expansion-of-an-existing-family-medicine-residency-program
#9
Evan A Ashkin, Warren P Newton, Brian Toomey, Ronald Lingley, Cristen P Page
BACKGROUND AND OBJECTIVES: Expanding residency training programs to address shortages in the primary care workforce is challenged by the present graduate medical education (GME) environment. The Medicare funding cap on new GME positions and reductions in the Health Resources and Services Administration (HRSA) Teaching Health Center (THC) GME program require innovative solutions to support primary care residency expansion. Sparse literature exists to assist in predicting the actual cost of incremental expansion of a family medicine residency program without federal or state GME support...
July 2017: Family Medicine
https://www.readbyqxmd.com/read/28724151/assessment-of-addiction-medicine-training-in-family-medicine-residency-programs-a-cera-study
#10
Sebastian Tong, Roy Sabo, Rebecca Aycock, Ramakrishna Prasad, Rebecca Etz, Anton Kuzel, Alex Krist
BACKGROUND AND OBJECTIVES: Substance use disorder (SUD) is a widespread problem but physicians may feel inadequately prepared to provide addiction care. We sought to assess current addiction medicine curricula in US family medicine residencies (FMRs) and evaluate barriers to improving or implementing addiction medicine curricula. METHODS: Questions regarding addiction medicine training were added to the December 2015 Council of Academic Family Medicine Educational Research Alliance (CERA) survey to US FMR program directors to evaluate each FMR's curriculum, potential workforce production, perceived barriers to improving or implementing curricula and faculty training in addiction medicine...
July 2017: Family Medicine
https://www.readbyqxmd.com/read/28724150/pregnancy-options-counseling-and-abortion-referrals-among-us-primary-care-physicians-results-from-a-national-survey
#11
Kelsey Holt, Elizabeth Janiak, Marie C McCormick, Ellice Lieberman, Christine Dehlendorf, Sandhya Kajeepeta, Jacquelyn M Caglia, Ana Langer
BACKGROUND AND OBJECTIVES: Primary care physicians (PCPs) can play a critical role in addressing unintended pregnancy through high-quality options counseling and referrals. METHODS: We surveyed a nationally representative sample of 3,000 PCPs in general, family, and internal medicine on practices and opinions related to options counseling for unintended pregnancy. We assessed predictors of physician practices using multivariable logistic regression weighted for sampling design and differential non-response...
July 2017: Family Medicine
https://www.readbyqxmd.com/read/28724149/using-reflections-to-evaluate-the-stfm-behavioral-science-family-systems-educator-fellowship
#12
Deborah A Taylor, Victoria Gorski, Sandra K Burge
BACKGROUND AND OBJECTIVES: A group of family medicine educators identified a need and developed a 1-year fellowship for early career behavioral science educators. This occurred in response to a reduction in previous opportunities and resources. The program was designed to shape and mentor new behavioral science faculty teaching in family medicine departments and programs. Quantitative data analysis from pre- and post-fellowship survey data from years 1-4 confirmed fellowship objectives were met...
July 2017: Family Medicine
https://www.readbyqxmd.com/read/28724148/integrative-medicine-in-residency-feasibility-and-effectiveness-of-an-online-program
#13
Patricia Lebensohn, Benjamin Kligler, Audrey J Brooks, Raymond Teets, Michele Birch, Paula Cook, Victoria Maizes
BACKGROUND AND OBJECTIVES: Online curricular interventions in residency have been proposed to address challenges of time, cost, and curriculum consistency. This study is designed to determine the feasibility and effectiveness of a longitudinal, multisite online curriculum in integrative medicine (IMR) for residents. METHODS: Residents from eight family medicine programs undertook the 200-hour online IMR curriculum. Their medical knowledge (MK) scores at completion were compared to a control group from four similar residency programs...
July 2017: Family Medicine
https://www.readbyqxmd.com/read/28724128/topical-corticosteroid-phobia-in-atopic-dermatitis-a-systematic-review
#14
Alvin W Li, Emily S Yin, Richard J Antaya
Importance: Topical corticosteroid (TCS) phobia refers to the negative feelings and beliefs related to TCSs experienced by patients and patients' caregivers. This phenomenon may be a major contributing factor in treatment failure in patients with atopic dermatitis, yet it has been sparsely described in the literature. Objective: To systematically assess the nomenclature, prevalence, origins, and effect on treatment adherence of TCS phobia in atopic dermatitis. Evidence Review: A literature search was conducted using specific eligibility criteria across electronic databases, including Ovid (MEDLINE, EMBASE), PubMed, and Web of Science, for articles published from January 1, 1946, to October 31, 2016...
July 19, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28724050/higher-meld-score-increases-the-overall-cost-on-the-waiting-list-for-liver-transplantation-a-micro-costing-analysis-based-study
#15
Jose Antonio Orellana Turri, Tassia Cristina Decimoni, Leandro Augusto Ferreira, Marcio Augusto Diniz, Luciana Bertocco de Paiva Haddad, Alessandro Gonçalves Campolina
BACKGROUND: The pre-transplant period is complex and includes lots of procedures. The severity of liver disease predisposes to a high number of hospitalizations and high costs procedures. Economic evaluation studies are important tools to handle costs on the waiting list for liver transplantation. OBJECTIVE: The objective of the present study was to evaluate the total cost of the patient on the waiting list for liver transplantation and the main resources related to higher costs...
July 13, 2017: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/28724045/spinal-tumors-in-children
#16
Andrei Fernandes Joaquim, Enrico Ghizoni, Marcelo Gomes Cordeiro Valadares, Simone Appenzeller, Simone Dos Santos Aguiar, Helder Tedeschi
Introduction: Spinal tumors are rare in the pediatric population, presenting many specific peculiarities when compared to adults. We have performed a broad narrative review to describe the most common spinal tumors in children, discussing their main characteristics and management options. Method: The authors have performed an extensive review of the peer-reviewed literature addressing the aforementioned objectives. Results: Multimodality radiological studies (plain films, 3D computed tomography scan and magnetic resonance imaging) are necessary for proper evaluation and differential diagnosis of spinal tumors in children...
May 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28724044/alcohol-and-tobacco-use-and-the-diseases-treated-in-general-practice
#17
Maria Flora de Almeida, Filipe Fernandes Ferreira, Mílton de Arruda Martins, Mario Ferreira
Objective: To characterize the use of alcohol and tobacco and correlate both to the diseases of outpatients in a general practice outpatient clinic. Method: The ASSIST (Alcohol, Smoking and Substance Involvement Screening Test) questionnaire was answered by 300 randomly chosen subjects assigned to different groups according to the diseases being treated at the Outpatient General and Teaching Clinic of the Department of Internal Medicine, Hospital das Clínicas of the University of São Paulo's School of Medicine (HC-FMUSP, in the Portuguese acronym), São Paulo, Brazil...
May 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28724036/clinical-pharmacology-profile-of-care-in-hepatology-clinic
#18
Talita Rocha Passos, Fabiana Silva Santos, Maria Cleusa Martins, Vanusa Barbosa Pinto, Flair José Carrilho, Suzane Kioko Ono
Since 2010, the Clinical Gastroenterology and Hepatology Division of the Central Institute of Hospital das Clínicas of the University of São Paulo Medical School (HC-FMUSP, in the Portuguese acronym) has been developing specialized electives assistance activities in the Outpatient Specialty Clinic, Secondary Level, in São Paulo NGA-63 Várzea do Carmo. The objective of this study was to analyze the pharmacotherapeutic profile of patients. This is a cross-sectional and retrospective study in which patients were seen at the Hepatology sector and the results were submitted to descriptive statistics...
May 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28724020/the-home-care-teaching-and-learning-process-in-undergraduate-health-care-degree-courses
#19
Ana Paula Hermann, Maria Ribeiro Lacerda, Mariluci Alves Maftum, Elizabeth Bernardino, Ana Lúcia Schaefer Ferreira de Mello
Home care, one of the services provided by the health system, requires health practitioners who are capable of understanding its specificities. This study aimed to build a substantive theory that describes experiences of home care teaching and learning during undergraduate degree courses in nursing, pharmacy, medicine, nutrition, dentistry and occupational therapy. A qualitative analysis was performed using the grounded theory approach based on the results of 63 semistructured interviews conducted with final year students, professors who taught subjects related to home care, and recent graduates working with home care, all participants in the above courses...
July 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28724011/the-aids-epidemic-and-the-mozambican-society-of-medicines-an-analysis-of-brazilian-cooperation
#20
Maíra da Silva Fedatto
This article analyzes the Brazilian South South Cooperation in Health in Mozambique, specifically the fight against the AIDS Epidemic through the Antiretroviral Factory, in light of the concept of Structural Cooperation in Health, and with a basis in the literature on Cooperation for Development and Global Health. Thus, the article is divided into four parts: (i) a historical-bibliographic review of health as an International Relations issue; (ii) an overview of the field of health in Mozambique; (iii) an historical-political-conceptual debate about both types of International Cooperation for Development: North-South Cooperation and South-South Cooperation; (iv) a study about the antiretroviral factory, better known as the Mozambican Society of Medicines (Sociedade Moçambicana de Medicamentos)...
July 2017: Ciência & Saúde Coletiva
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