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JOURNAL ARTICLE
Franziska Emmerich, Julia Junghans, Markus Zenger, Elmar Brähler, Yve Stöbel-Richter, Lisa Irmscher, Ernst Peter Richter, Hendrik Berth
Background : The COVID-19 outbreak necessitated physical distancing, as part of secondary prevention, at a personal and professional level. Working from home (WFH) became increasingly important. In this study, the impact of the COVID-19 pandemic restrictions on physical and mental health is investigated, compared with pre-pandemic data, and with employees who WFH and are on-site. Methods : Data from the German Saxon longitudinal study population were used. Attitudes towards WFH as well as mental and physical health assessments during the COVID-19 pandemic were examined...
April 5, 2024: Healthcare (Basel, Switzerland)
#22
JOURNAL ARTICLE
Bjørn Morten Hofmann, Ingrid Øfsti Brandsaeter, Eivind Richter Andersen, Jan Porthun, Elin Kjelle
BACKGROUND: Unwarranted temporal and geographical variations are acknowledged as a profound problem for equal access and justice in the provision of health services. Even more, they challenge the quality, safety, and efficiency of such services. This is highly relevant for imaging services. OBJECTIVE: To analyse the temporal and geographical variation in the number of diagnostic images in Norway from 2013 to 2021. METHODS: Data on outpatient imaging provided by the Norwegian Health Economics Administration (HELFO) and inpatient data afforded by fourteen hospital trusts and hospitals in Norway...
April 12, 2024: BMC Health Services Research
#23
JOURNAL ARTICLE
Georgia Kouri, Nathalie Meuwly, Marianne Richter, Dominik Schoebi
BACKGROUND: In intimate relationships, which are characterized by emotional interdependence, partners act as attachment figures which serve emotion regulation functions. The experience of emotions as well as the strategies that partners use to regulate them and to respond to relational experiences, especially during stressful periods, differ greatly according to their attachment orientation. An important aspect in emotion dynamics is emotional inertia, which reflects the degree to which a person's current affective state is resistant to change on a moment-to-moment basis...
April 12, 2024: BMC Psychology
#24
JOURNAL ARTICLE
Albert Gargallo-Garriga, Jordi Sardans, Joan Llusià, Guille Peguero, Marta Ayala-Roque, Elodie A Courtois, Clément Stahl, Otmar Urban, Karel Klem, Pau Nolis, Miriam Pérez-Trujillo, Teodor Parella, Andreas Richter, Ivan A Janssens, Josep Peñuelas
BACKGROUND: The availability of soil phosphorus (P) often limits the productivities of wet tropical lowland forests. Little is known, however, about the metabolomic profile of different chemical P compounds with potentially different uses and about the cycling of P and their variability across space under different tree species in highly diverse tropical rainforests. RESULTS: We hypothesised that the different strategies of the competing tree species to retranslocate, mineralise, mobilise, and take up P from the soil would promote distinct soil 31 P profiles...
April 12, 2024: BMC Plant Biology
#25
EDITORIAL
Joshua Richter
No abstract text is available yet for this article.
April 12, 2024: Blood Cancer Journal
#26
JOURNAL ARTICLE
Taylor L Rystrom, S Helene Richter, Norbert Sachser, Sylvia Kaiser
Individualized social niches arise in social groups, resulting in divergent social behavior profiles among group members. During sensitive life phases, the individualized social niche can profoundly impact the development of social behavior and associated phenotypes such as hormone (e.g. cortisol) concentrations. Focusing on adolescence, we investigated the relationship between the individualized social niche, social behavior, and cortisol concentrations (baseline and responsiveness) in female guinea pigs. Females were pair-housed in early adolescence (initial social pair formation), and a social niche transition was induced after six weeks by replacing the partner with either a larger or smaller female...
April 11, 2024: Hormones and Behavior
#27
JOURNAL ARTICLE
Christian S Carl, Marie M Jensen, Kim A Sjøberg, Dumitru Constantin-Teodosiu, Ian R Hill, Rasmus Kjøbsted, Paul L Greenhaff, Jørgen F P Wojtaszewski, Erik A Richter, Andreas M Fritzen, Bente Kiens
Insulin resistance is a risk factor for type 2 diabetes and exercise can improve insulin sensitivity. However, following exercise high circulating fatty acid (FA) levels might counteract this. We hypothesized that such inhibition would be reduced by forcibly increasing carbohydrate oxidation through pharmacological activation of the pyruvate dehydrogenase complex (PDC). Insulin-stimulated glucose uptake was examined with a cross-over design in healthy young men (n = 8) in a previously exercised and a rested leg during a hyperinsulinemiceuglycemic clamp five hours after one-legged exercise with: 1) infusion of saline, 2) infusion of intralipid imitating circulating FA levels during recovery from whole-body exercise, and 3) infusion of intralipid + oral PDC-activator, dichloroacetate (DCA)...
April 12, 2024: Diabetes
#28
JOURNAL ARTICLE
Melad Henis, Tabitha Rücker, Robin Scharrenberg, Melanie Richter, Lucas Baltussen, Shuai Hong, Durga Praveen Meka, Birgit Schwanke, Nagammal Neelagandan, Danie Daaboul, Nadeem Murtaza, Christoph Krisp, Sönke Harder, Hartmut Schlüter, Matthias Kneussel, Irm Hermans-Borgmeyer, Joris de Wit, Karun K Singh, Kent E Duncan, Froylan Calderón de Anda
Genes implicated in translation control have been associated with autism spectrum disorders (ASDs). However, some important genetic causes of autism, including the 16p11.2 microdeletion, bear no obvious connection to translation. Here, we use proteomics, genetics, and translation assays in cultured cells and mouse brain to reveal altered translation mediated by loss of the kinase TAOK2 in 16p11.2 deletion models. We show that TAOK2 associates with the translational machinery and functions as a translational brake by phosphorylating eukaryotic elongation factor 2 (eEF2)...
April 12, 2024: Science Advances
#29
JOURNAL ARTICLE
Sarah K Nørgaard, Jens Nielsen, Anne Christine Nordholm, Lukas Richter, Alena Chalupka, Natalia Bustos Sierra, Toon Braeye, Maria Athanasiadou, Theodore Lytras, Gleb Denissov, Oskari Luomala, Anne Fouillet, Isabelle Pontais, Matthias An der Heiden, Benedikt Zacher, Alina Weigel, Ivo Foppa, Kassiani Gkolfinopoulou, Ioannis Panagoulias, Anna Paldy, Tibor Malnasi, Lisa Domegan, Eva Kelly, Naama Rotem, Oksana Rakhlin, Francesca K de'Donato, Chiara Di Blasi, Patrick Hoffmann, Telma Velez, Kathleen England, Neville Calleja, Liselotte van Asten, Femke Jongenotter, Ana Paula Rodrigues, Susana Silva, Petra Klepac, Diana Gomez-Barroso, Inmaculada Leon Gomez, Ilias Galanis, Ahmed Farah, Rolf Weitkunat, Katarina Fehst, Nick Andrews, Tom Clare, Declan T Bradley, Mark G O'Doherty, Naoma William, Mark Hamilton, Bolette Søborg, Tyra G Krause, Nick Bundle, Lasse S Vestergaard
Since the end of November 2023, the European Mortality Monitoring Network (EuroMOMO) has observed excess mortality in Europe. During weeks 48 2023-6 2024, preliminary results show a substantially increased rate of 95.3 (95% CI: 91.7-98.9) excess all-cause deaths per 100,000 person-years for all ages. This excess mortality is seen in adults aged 45 years and older, and coincides with widespread presence of COVID-19, influenza and respiratory syncytial virus (RSV) observed in many European countries during the 2023/24 winter season...
April 2024: Euro Surveillance
#30
JOURNAL ARTICLE
T L Qiu, J Y Li, Y Xia
Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western adults, although the incidence of CLL is relatively low in Asian populations. However, with the aging population, the incidence of CLL is increasing in China. The interaction between CLL cells and the microenvironment plays a crucial role in the recognition of antigens by the B-cell receptor immunoglobulin (BCR IG). The mutational status of the immunoglobulin heavy variable region (IGHV) is a classical prognostic marker for CLL. Over 40% of CLL patients exhibit biased usage of IGHV and highly similar amino acid sequences in the heavy complementarity-determining region 3 (HCDR3), known as the BCR stereotypy...
February 14, 2024: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
#31
JOURNAL ARTICLE
Ida Stangerup, Sasha A S Kjeldsen, Michael M Richter, Nicole Jacqueline Jensen, Jørgen Rungby, Steen Bendix Haugaard, Birgitte Georg, Jens Hannibal, Kjeld Møllgård, Nicolai J Wewer Albrechtsen, Camilla Bjørnbak Holst
Glucagon is best known for its contribution to glucose regulation through activation of the glucagon receptor (GCGR), primarily located in the liver. However, glucagon's impact on other organs may also contribute to its potent effects in health and disease. Given that glucagon-based medicine is entering the arena of anti-obesity drugs, elucidating extrahepatic actions of glucagon are of increased importance. It has been reported that glucagon may stimulate secretion of arginine-vasopressin (AVP)/copeptin, growth hormone (GH) and adrenocorticotrophic hormone (ACTH) from the pituitary gland...
April 9, 2024: Peptides
#32
JOURNAL ARTICLE
Adree Khondker, Mandy Rickard, Jin Kyu Kim, Julianne Richter, Margarita Chancy, Kay Rivera, Joana Dos Santos, Michael Chua, Armando J Lorenzo
PURPOSE: To describe long-term outcomes, including urinary tract infections (UTIs) and need for reimplantation, after ureterovesicostomy (UV) as a lasting surgical procedure for children with primary obstructed megaureter (POM). METHODS: Children referred to our institution between 2016 and 2023 who underwent refluxing UV were analyzed. POM was defined as hydroureteronephrosis with distal ureteral dilatation > 7 mm and a negative workup for other aetiologies of hydronephrosis...
April 11, 2024: Journal of Urology
#33
JOURNAL ARTICLE
Alexander Schmidt, Michael Sigl-Kraetzig, Heinrich Richter, Tim Vogler, Fabian Tomschi, Thomas Hilberg
BACKGROUND: Patients with haemophilia (PwH) suffer from chronic pain due to joint alterations induced by recurring haemorrhage. OBJECTIVES: This study aimed to investigate the relationship between structural alterations and pain perception at the ankle joint in PwH. PATIENTS/METHODS: Ankle joints of 79 PwH and 57 healthy controls (Con) underwent ultrasound examination (US) and assessment of pain sensitivity via pressure pain thresholds (PPT)...
April 10, 2024: Haemophilia: the Official Journal of the World Federation of Hemophilia
#34
JOURNAL ARTICLE
Martin Stuebler, Zachary A Manzer, Han-Yuan Liu, Julia Miller, Annett Richter, Srinivasan Krishnan, Ekaterina Selivanovitch, Barituziga Banuna, Georg Jander, Erik Reimhult, Warren R Zipfel, Adrienne H K Roeder, Miguel A Piñeros, Susan Daniel
The cell plasma membrane is a two-dimensional, fluid mosaic material composed of lipids and proteins that create a semipermeable barrier defining the cell from its environment. Compared with soluble proteins, the methodologies for the structural and functional characterization of membrane proteins are challenging. An emerging tool for studies of membrane proteins in mammalian systems is a "plasma membrane on a chip," also known as a supported lipid bilayer. Here, we create the "plant-membrane-on-a-chip,″ a supported bilayer made from the plant plasma membranes of Arabidopsis thaliana , Nicotiana benthamiana , or Zea mays ...
April 9, 2024: ACS Applied Materials & Interfaces
#35
JOURNAL ARTICLE
Gali Estopare Araguirang, Benedikt Venn, Nadja-Magdalena Kelber, Regina Feil, John Lunn, Tatjana Kleine, Dario Leister, Timo Mühlhaus, Andreas S Richter
Plant acclimation to an ever-changing environment is decisive for growth, reproduction, and survival. Light availability limits biomass production on both ends of the intensity spectrum. Therefore, the adjustment of plant metabolism is central to high-light (HL) acclimation, and the accumulation of photoprotective anthocyanins is commonly observed. However, mechanisms and factors regulating the HL acclimation response are less clear. Two Arabidopsis mutants of spliceosome components exhibiting a pronounced anthocyanin overaccumulation in HL were isolated from a forward genetic screen for new factors crucial for plant acclimation...
April 9, 2024: Plant Journal
#36
RANDOMIZED CONTROLLED TRIAL
Philip C Schouten, Sandra Schmidt, Kerstin Becker, Holger Thiele, Peter Nürnberg, Lisa Richters, Corinna Ernst, Isabelle Treilleux, Jacques Medioni, Florian Heitz, Carmela Pisano, Yolanda Garcia, Edgar Petru, Sakari Hietanen, Nicoletta Colombo, Ignace Vergote, Shoji Nagao, Sabine C Linn, Eric Pujade-Lauraine, Isabelle Ray-Coquard, Philipp Harter, Eric Hahnen, Rita K Schmutzler
IMPORTANCE: Testing for homologous recombination deficiency is required for the optimal treatment of high-grade epithelial ovarian cancer. The search for accurate biomarkers is ongoing. OBJECTIVE: To investigate whether progression-free survival (PFS) and overall survival (OS) of patients with high-grade epithelial ovarian cancer treated with maintenance olaparib or placebo differed between patients with a tumor BRCA-like genomic profile and patients without a tumor BRCA-like profile...
April 1, 2024: JAMA Network Open
#37
JOURNAL ARTICLE
Christina Klus, Katja Krumm, Sindy Jacobi, Marie-Christin Willemer, Charlotte Daub, Dietrich Stoevesandt, Katrin Metzler, Carolin Richter, Lisa-Maria Peter, Steffen Heide, Uwe Schmidt
Conducting external post-mortem examinations is an essential skill required of physicians in various countries, regardless of their specialization. However, the quality of these examinations has been a subject of continuous debates, and notable errors were reviled. In response to these shortcomings, a virtual reality (VR) application was developed at Halle's medical department in Germany, focusing on the scene of discovery and the completion of death certificates. The initial trial of this VR application in 2020 involved 39 students and 15 early-career professionals...
April 9, 2024: International Journal of Legal Medicine
#38
JOURNAL ARTICLE
Vered Richter, Daniel L Cohen, Ofra Kriger-Sharabi, Dana Zelnik Yovel, Nadav Kochen, Efrat Broide, Haim Shirin
Biological inflammatory bowel disease (IBD) medications, once limited to intravenous (IV) administration, can now be administered both via IV and subcutaneously (SC). This study investigates patient preferences, willingness to switch from IV to SC, and associated factors. A questionnaire covering demographics, disease-related inquiries, quality of life, and IBD medication preferences was distributed via email, the Israeli Crohn's Disease and Ulcerative Colitis Foundation, infusion centers, and clinics. From 454 IBD patients (median age: 42 years; 55...
February 27, 2024: Journal of Clinical Medicine
#39
JOURNAL ARTICLE
Rüdiger W Seidel, Richard Goddard, Markus Lang, Adrian Richter
Tuberculosis (TB), mainly caused by Mycobacterium tuberculosis, remains the leading cause of death from a bacterium in the world. The global prevalence of clinically relevant infections with opportunistically pathogenic non-tuberculous mycobacteria (NTM) have also been on the rise. Pharmacological treatment of both TB and NTM infections usually requires prolonged regimens of drug combinations, and is often challenging because of developed or inherent resistance to common antibiotic drugs. Medicinal chemistry efforts are thus needed to improve treatment options and therapeutic outcomes...
April 8, 2024: Chemistry & Biodiversity
#40
JOURNAL ARTICLE
Chiara Vaccaro, Karel Dewulf, Konstantin Richter, Nicolas Branger, Stanislas Rybikowski, Thomas Maubon, Jochen Walz, Geraldine Pignot
No abstract text is available yet for this article.
April 8, 2024: BJU International
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