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https://www.readbyqxmd.com/read/28431137/trapp-webserver-predicting-protein-binding-site-flexibility-and-detecting-transient-binding-pockets
#1
Antonia Stank, Daria B Kokh, Max Horn, Elena Sizikova, Rebecca Neil, Joanna Panecka, Stefan Richter, Rebecca C Wade
The TRAnsient Pockets in Proteins (TRAPP) webserver provides an automated workflow that allows users to explore the dynamics of a protein binding site and to detect pockets or sub-pockets that may transiently open due to protein internal motion. These transient or cryptic sub-pockets may be of interest in the design and optimization of small molecular inhibitors for a protein target of interest. The TRAPP workflow consists of the following three modules: (i) TRAPP structure- generation of an ensemble of structures using one or more of four possible molecular simulation methods; (ii) TRAPP analysis-superposition and clustering of the binding site conformations either in an ensemble of structures generated in step (i) or in PDB structures or trajectories uploaded by the user; and (iii) TRAPP pocket-detection, analysis, and visualization of the binding pocket dynamics and characteristics, such as volume, solvent-exposed area or properties of surrounding residues...
April 20, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28431009/artefact-free-late-gadolinium-enhancement-imaging-in-patients-with-implanted-cardiac-devices-using-a-modified-broadband-sequence-current-strategies-and-results-from-a-real-world-patient-cohort
#2
Sebastian Hilbert, Alexander Weber, Kay Nehrke, Peter Börnert, Bernhard Schnackenburg, Sabrina Oebel, Ricardo Spampinato, Cathleen Rogge, Sergio Richter, Gerhard Hindricks, Ingo Paetsch, Cosima Jahnke
Aims: Cardiac magnetic resonance (CMR) imaging in patients with implanted cardiac devices is often limited by device-related imaging artefacts. Limitations can potentially be overcome by employing a broadband late gadolinium enhancement (LGE)-CMR imaging technique. The purpose of this study was to investigate the relationship between implanted cardiac devices and the optimal frequency offset on broadband LGE-CMR imaging to increase the artefact-free visibility of myocardial segments. Methods and results: A phantom study was performed to characterize magnetic field disturbances related to 15 different cardiac devices...
April 18, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28430184/the-ubiquitin-ligase-lin41-trim71-targets-p53-to-antagonize-cell-death-and-differentiation-pathways-during-stem-cell-differentiation
#3
Duong Thi Thuy Nguyen, Daniel Richter, Geert Michel, Sibylle Mitschka, Waldemar Kolanus, Elisa Cuevas, F Gregory Wulczyn
Rapidity and specificity are characteristic features of proteolysis mediated by the ubiquitin-proteasome system. Therefore, the UPS is ideally suited for the remodeling of the embryonic stem cell proteome during the transition from pluripotent to differentiated states and its inverse, the generation of inducible pluripotent stem cells. The Trim-NHL family member LIN41 is among the first E3 ubiquitin ligases to be linked to stem cell pluripotency and reprogramming. Initially discovered in C. elegans as a downstream target of the let-7 miRNA, LIN41 is now recognized as a critical regulator of stem cell fates as well as the timing of neurogenesis...
April 21, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28429269/alternative-carbon-dioxide-modelling-approaches-accounting-for-high-residual-gases-in-landgem
#4
Nathan Bruce, Kelvin Tsun Wai Ng, Amy Richter
High Canadian waste disposal rates necessitate landfill gas monitoring and accurate forecasting. CO2 estimates in LandGEM version 3.02 currently rest on the assumptions that CO2 is a function of CH4, where the two gases make up nearly 100% of landfill gas content, leading to overestimated CO2 collection estimates. A total of 25 cases (five formulas, five approaches) compared annual CO2 collection at four western Canadian landfills. Despite common use in literature, the 1:1 ratio of CH4 to CO2 was not recommended to forecast landfill gas collection in cold climates...
April 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28429118/-how-frequent-are-poor-prognostic-markers-in-rheumatoid-arthritis-an-estimate-based-on-three-epidemiologic-cohorts
#5
K Albrecht, A Richter, Y Meissner, D Huscher, L Baganz, K Thiele, M Schneider, A Strangfeld, A Zink
BACKGROUND: Unfavorable prognostic factors-high disease activity, early erosions, and autoantibodies-should be considered when making treatment decisions in rheumatoid arthritis (RA). There are little data on the frequency of individual poor prognostic factors among RA patients in daily care. METHODS: Disease activity (Disease Activity Score, DAS28), erosions, antibodies against citrullinated peptides or rheumatoid factor (ACPA/RF+), previous treatment failure, inflammation markers, and functional disability (FFbH < 70) were defined as prognostic factors...
April 20, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28429083/intravenous-treprostinil-infusion-via-a-fully-implantable-pump-for-pulmonary-arterial-hypertension
#6
Ralf Ewert, Manuel J Richter, Regina Steringer-Mascherbauer, Ekkehard Grünig, Tobias J Lange, Christian F Opitz, Christian Warnke, Hossein-Ardeschir Ghofrani
OBJECTIVES: Parenteral prostanoids infused via external pumps are well-established pulmonary arterial hypertension (PAH) treatments. However, local side-effects and systemic infections restrict their use. The purpose of this study was to investigate the safety of a fully implantable treprostinil infusion pump (LENUS Pro(®)) in patients with PAH. METHODS: Thirty patients with PAH undergoing pump implantation (with stable PAH therapy for ≥3 weeks pre-implantation) were included in this prospective, multicenter, observational study (NCT01979822)...
April 20, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28428873/a-maize-landrace-that-emits-defense-volatiles-in-response-to%C3%A2-herbivore-eggs-possesses-a-strongly-inducible-terpene-synthase-gene
#7
Amanuel Tamiru, Toby J A Bruce, Annett Richter, Christine M Woodcock, Charles A O Midega, Jörg Degenhardt, Segenet Kelemu, John A Pickett, Zeyaur R Khan
Maize (Zea mays) emits volatile terpenes in response to insect feeding and egg deposition to defend itself against harmful pests. However, maize cultivars differ strongly in their ability to produce the defense signal. To further understand the agroecological role and underlying genetic mechanisms for variation in terpene emission among maize cultivars, we studied the production of an important signaling component (E)-caryophyllene in a South American maize landrace Braz1006 possessing stemborer Chilo partellus egg inducible defense trait, in comparison with the European maize line Delprim and North American inbred line B73...
April 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28426143/coronal-transcranial-sonography-and-m-mode-tremor-frequency-determination-in-parkinson-s-disease-and-essential-tremor
#8
Daniel Richter, Dirk Woitalla, Siegfried Muhlack, Ralf Gold, Lars Tönges, Christos Krogias
BACKGROUND AND PURPOSE: The axial mesencephalic transcranial sonography plane is an established and sensitive diagnostic tool for the differentiation of Parkinson's disease and essential tremor. However, the substantia nigra can also be depicted in a second coronal examination plane, whose diagnostic value has not yet been evaluated. Furthermore, the M-mode tremor frequency determination represents another sonographic tool, which might yield additional diagnostic value. METHODS: We included patients with diagnosed Parkinson's disease (n = 31), essential tremor (n = 16), and healthy age-matched controls (n = 16)...
April 20, 2017: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/28425999/three-dimensional-printing-of-transparent-fused-silica-glass
#9
Frederik Kotz, Karl Arnold, Werner Bauer, Dieter Schild, Nico Keller, Kai Sachsenheimer, Tobias M Nargang, Christiane Richter, Dorothea Helmer, Bastian E Rapp
Glass is one of the most important high-performance materials used for scientific research, in industry and in society, mainly owing to its unmatched optical transparency, outstanding mechanical, chemical and thermal resistance as well as its thermal and electrical insulating properties. However, glasses and especially high-purity glasses such as fused silica glass are notoriously difficult to shape, requiring high-temperature melting and casting processes for macroscopic objects or hazardous chemicals for microscopic features...
April 19, 2017: Nature
https://www.readbyqxmd.com/read/28424162/pembrolizumab-in-patients-with-chronic-lymphocytic-leukemia-with-richter-s-transformation-and-relapsed-cll
#10
Wei Ding, Betsy R LaPlant, Timothy G Call, Sameer A Parikh, Jose F Leis, Rong He, Tait D Shanafelt, Sutapa Sinha, Jennifer Le-Rademacher, Andrew L Feldman, Thomas M Habermann, Thomas E Witzig, Gregory A Wiseman, Yi Lin, Erik Asmus, Grzegorz S Nowakowski, Michael J Conte, Deborah A Bowen, Casey N Aitken, Daniel L Van Dyke, Patricia T Greipp, Xin Liu, Xiaosheng Wu, Henan Zhang, Charla R Secreto, Shulan Tian, Esteban Braggio, Linda E Wellik, Ivana Micallef, David S Viswanatha, Huihuang Yan, Asher A Chanan-Khan, Neil E Kay, Haidong Dong, Stephen M Ansell
CLL patients progressed early on ibrutinib often develop Richter's transformation (RT) with short survival about 4 months. Preclinical studies suggest that programmed death 1 (PD-1) pathway is critical to inhibit immune surveillance in CLL. This phase 2 study MC1485 (NCT02332980) was designed to test the efficacy and safety of pembrolizumab, a humanized PD-1-blocking antibody, at a dose of 200 mg every 3 weeks in relapsed and transformed CLL. Twenty-five patients including 16 relapsed CLL and 9 RT (all proven diffuse large cell lymphoma) patients were enrolled and 60% received prior ibrutinib...
April 19, 2017: Blood
https://www.readbyqxmd.com/read/28423444/-comment-on-the-technique-of-enhanced-percutaneous-needle-fasciotomy-pnf-for-dupuytren-s-contracture
#11
Martin Richter
No abstract text is available yet for this article.
February 2017: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/28423077/early-devonian-late-emsian-shark-fin-remains-chondrichthyes-from-the-paran%C3%A3-basin-southern-brazil
#12
Martha Richter, Elvio P Bosetti, Rodrigo S Horodyski
We report on the pioneering discovery of Devonian fish remains in the Paraná Basin, which represents the southernmost record of fishes from that period in mainland South America. The material comes from an outcrop at the lower portion of the São Domingos Formation, within Sequence C of the Paraná-Apucarana sub-basin in Tibagi, State of Paraná. Marine invertebrates are abundant in the same strata. The dark colored fish remains were collected in situ and represent natural moulds of partially articulated shark fin rays (radials)...
January 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28419691/the-low-diverse-gastric-microbiome-of-the-jellyfish-cotylorhiza-tuberculata-is-dominated-by-four-novel-taxa
#13
Tomeu Viver, Luis H Orellana, Janet K Hatt, Mercedes Urdiain, Sara Díaz, Michael Richter, Josefa Antón, Massimo Avian, Rudolf Amann, Konstantinos T Konstantinidis, Ramon Rosselló-Móra
Cotylorhiza tuberculata is an important scyphozoan jellyfish producing population blooms in the Mediterranean probably due to pelagic ecosystem's decay. Its gastric cavity can serve as a simple model of microbial - animal digestive associations, yet poorly characterized. Using state-of-the-art metagenomic population binning and catalyzed reporter deposition fluorescence in situ hybridization (CARD-FISH), we show that only four novel clonal phylotypes were consistently associated with multiple jellyfish adults...
April 17, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28414478/enhancing-effects-of-contingency-instructions-on-fear-acquisition-and-extinction-in-anxiety-disorders
#14
Puck Duits, Jan Richter, Johanna M P Baas, Iris M Engelhard, Anke Limberg-Thiesen, Ivo Heitland, Alfons O Hamm, Danielle C Cath
Explicit instructions regarding stimulus-threat associations increase acquisition and extinction of fear in healthy participants. The current study aimed to investigate the effect of contingency instructions on fear acquisition and extinction in patients with anxiety disorders. Patients with various anxiety disorders (N = 104) and healthy comparison participants (N = 93) participated in a differential fear conditioning task (within-subjects design). Approximately halfway through the acquisition phase, participants were instructed about the stimulus-threat association, and approximately halfway through the extinction phase, participants were informed that the unconditioned stimulus (US) would no longer be administered...
April 17, 2017: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/28414244/morphology-development-in-solution-processed-functional-organic-blend-films-an-in-situ-viewpoint
#15
Lee J Richter, Dean M DeLongchamp, Aram Amassian
Solution-processed organic films are a facile route to high-speed, low cost, large-area deposition of electrically functional components (transistors, solar cells, emitters, etc.) that can enable a diversity of emerging technologies, from Industry 4.0, to the Internet of things, to point-of-use heath care and elder care. The extreme sensitivity of the functional performance of organic films to structure and the general nonequilibrium nature of solution drying result in extreme processing-performance correlations...
April 17, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/28414146/tissue-distribution-of-a-therapeutic-monoclonal-antibody-determined-by-large-pore-microdialysis
#16
Satyawan B Jadhav, Vipada Khaowroongrueng, Matthias Fueth, Michael B Otteneder, Wolfgang Richter, Hartmut Derendorf
Therapeutic monoclonal antibodies (mAbs) exhibit limited distribution to the target tissues. Determination of target tissue interstitial concentration of mAbs is an important aspect in the assessment of their pharmacokinetic/pharmacodynamics (PK/PD) relationship especially for mAbs targeting membrane bound receptors. The pharmacokinetics of R7072, a full length mAb (IgG) targeting human insulin like growth factor-1 receptor (IGF-1R) was evaluated following a single intravenous (IV) dose at 1, 6.25 and 25 mg/kg in healthy female SCID-beige mice...
April 13, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28413479/inhalative-and-intravenous-stimulation-of-soluble-guanylate-cyclase-reduces-pulmonary-vascular-resistance-and-increases-cardiac-output-in-experimental-septic-shock
#17
Nils Kronas, Birte Peters, Hans Peter Richter, Alwin Eduard Goetz, Jens Christian Kubitz
The effects of inhaled and intravenous application of a guanylate cyclase stimulator (BAY 41-8543) on pulmonary vascular resistance (PVR) and cardiac output (CO) were investigated in an experimental model of septic shock. Following induction of septic shock, anaesthetized pigs (n=31) were randomly place into two groups receiving different interventions. Animals in the first group received intravenous BAY 41-8543 (0.6 mg), inhalative BAY 41-8543 (6 mg) or a placebo. In the second group, the dosage of BAY 41-8543 was increased two-fold or combined with inhalation of nitric oxide (iNO)...
April 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28412474/kinetics-for-drug-discovery-an-industry-driven-effort-to-target-drug-residence-time
#18
REVIEW
Doris A Schuetz, Wilhelmus Egbertus Arnout de Witte, Yin Cheong Wong, Bernhard Knasmueller, Lars Richter, Daria B Kokh, S Kashif Sadiq, Reggie Bosma, Indira Nederpelt, Elena Segala, Marta Amaral, Dong Guo, Dorothee Andres, Victoria Georgi, Leigh A Stoddart, Steve Hill, Robert M Cooke, Chris De Graaf, Rob Leurs, Matthias Frech, Rebecca C Wade, Elizabeth Cunera Maria de Lange, Adriaan P IJzerman, Anke Müller-Fahrnow, Gerhard F Ecker
A considerable number of approved drugs show non-equilibrium binding characteristics, emphasizing the potential role of drug residence times for in vivo efficacy. Therefore, a detailed understanding of the kinetics of association and dissociation of a target-ligand complex might provide crucial insight into the molecular mechanism-of-action of a compound. This deeper understanding will help to improve decision making in drug discovery, thus leading to a better selection of interesting compounds to be profiled further...
April 12, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28412374/a-novel-mitochondrial-atp6-frameshift-mutation-causing-isolated-complex-v-deficiency-ataxia-and-encephalomyopathy
#19
Christopher Benjamin Jackson, Dagmar Hahn, Barbara Schröter, Uwe Richter, Brendan Battersby, Thomas Schmitt-Mechelke, Paula Martinen, Jean-Marc Nuoffer, André Schaller
We describe a novel frameshift mutation in the mitochondrial ATP6 gene in a 4-year-old girl associated with ataxia, microcephaly, developmental delay and intellectual disability. A heteroplasmic frameshift mutation in the MT-ATP6 gene was confirmed in the patient's skeletal muscle and blood. The mutation was not detectable in the mother's DNA extracted from blood or buccal cells. Enzymatic and oxymetric analysis of the mitochondrial respiratory system in the patients' skeletal muscle and skin fibroblasts demonstrated an isolated complex V deficiency...
April 12, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/28409290/comparison-of-clinical-and-laboratory-characteristics-during-two-major-paediatric-meningitis-outbreaks-of-echovirus-30-and-other-non-polio-enteroviruses-in-germany-in-2008-and-2013
#20
H Rudolph, R Prieto Dernbach, M Walka, P Rey-Hinterkopf, V Melichar, E Muschiol, S Schweitzer-Krantz, J W Richter, C Weiss, S Böttcher, S Diedrich, H Schroten, T Tenenbaum
Viral meningitis is mainly caused by non-polio enteroviruses (NPEV). Large-scale data on the clinical characteristics between different outbreaks within the same region are lacking. This study aimed to analyse a possible influence of the circulating NPEV genotype on the disease outcome of affected children. A retrospective cohort study analysing two major outbreaks of NPEV meningitis in Germany in 2008 and 2013 was conducted in cooperation with the National Reference Centre for Poliomyelitis and Enteroviruses (NRC PE) and five German children's hospitals...
April 13, 2017: European Journal of Clinical Microbiology & Infectious Diseases
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