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https://www.readbyqxmd.com/read/28934806/radiation-exposure-during-uterine-fibroid-embolization-ufe-a-confounder-controlled-comparison-between-a-state-of-the-art-angiography-unit-and-a-conventional-angiography-unit
#1
Christof-Matthias Sommer, Wieland Voigt, Michel Klapp Oliger, Christopher L Schlett, Stefan Erpenbach, Katrina Thomas, Andreas Hatopp, Patrick Kurz, Goetz M Richter
Purpose To compare radiation exposure of a state-of-the-art and a conventional angiography unit in patients undergoing uterine fibroid embolization (UFE). Materials and Methods Between January 2009 and December 2016, 286 patients underwent UFE in our Interdisciplinary Fibroid Center. The inclusion criteria for this retrospective analysis were first-time transarterial embolization for symptomatic fibroids, bilateral embolization, procedures applying a state-of-the-art (Group 1) or a conventional angiography unit (Group 2), and bilateral technical success with an adequate embolization endpoint after the injection of microspheres...
September 21, 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/28933576/impact-of-a-mental-health-nursing-training-programme-on-the-perceived-recovery-orientation-of-patients-and-nurses-on-acute-psychiatric-wards-results-of-a-pilot-study
#2
Gianfranco Zuaboni, Sabine Hahn, Peter Wolfensberger, Thomas Schwarze, Dirk Richter
In mental health nursing, recovery-orientation is regarded as a best practice approach for patient care. To assess the effect of an intervention utilising a recovery-oriented approach in acute practice, a controlled pilot trial was conducted. On intervention wards, mental health nurses received special training. Recovery Self-Assessment Scale was used to assess the effects of the training. No statistically significant effects were found, between the experimental conditions. Reasons for this result may be methodological, practical or due an intervention that was not powerful enough...
September 21, 2017: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/28931679/pathogenic-correlates-of-the-simian-immunodeficiency-virus-siv-associated-b-cell-dysfunction
#3
Egidio Brocca-Cofano, David Kuhrt, Basile Siewe, Cuiling Xu, George S Haret-Richter, Jodi Craigo, Celia Labranche, David C Montefiori, Alan Landay, Cristian Apetrei, Ivona Pandrea
We compared and contrasted pathogenic (pigtailed macaques-PTMs) and nonpathogenic (African green monkeys-AGMs) SIVsab infections to assess the significance of the B-cell dysfunction observed in SIV/HIV infection. We report that the loss of B cells is specifically associated with the pathogenic SIV infection, while in the nonpathogenic natural hosts B cells rapidly increase in both LNs and intestine. SIV-associated B-cell dysfunction associated to the pathogenic SIV infection is characterized by loss of naïve B cells; loss of resting memory B cells due to their redistribution to the gut; increases of the activated B cells and circulating tissue-like memory B cells and expansion of the B regulatory cells...
September 20, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28930680/systematic-kinase-inhibitor-profiling-identifies-cdk9-as-a-synthetic-lethal-target-in-nut-midline-carcinoma
#4
Johannes Brägelmann, Marcel A Dammert, Felix Dietlein, Johannes M Heuckmann, Axel Choidas, Stefanie Böhm, André Richters, Debjit Basu, Verena Tischler, Carina Lorenz, Peter Habenberger, Zhizhou Fang, Sandra Ortiz-Cuaran, Frauke Leenders, Jan Eickhoff, Uwe Koch, Matthäus Getlik, Martin Termathe, Muhammad Sallouh, Zoltán Greff, Zoltán Varga, Hyatt Balke-Want, Christopher A French, Martin Peifer, H Christian Reinhardt, László Örfi, György Kéri, Sascha Ansén, Lukas C Heukamp, Reinhard Büttner, Daniel Rauh, Bert M Klebl, Roman K Thomas, Martin L Sos
Kinase inhibitors represent the backbone of targeted cancer therapy, yet only a limited number of oncogenic drivers are directly druggable. By interrogating the activity of 1,505 kinase inhibitors, we found that BRD4-NUT-rearranged NUT midline carcinoma (NMC) cells are specifically killed by CDK9 inhibition (CDK9i) and depend on CDK9 and Cyclin-T1 expression. We show that CDK9i leads to robust induction of apoptosis and of markers of DNA damage response in NMC cells. While both CDK9i and bromodomain inhibition over time result in reduced Myc protein expression, only bromodomain inhibition induces cell differentiation and a p21-induced cell-cycle arrest in these cells...
September 19, 2017: Cell Reports
https://www.readbyqxmd.com/read/28930296/the-verified-neighbor-approach-to-geoprivacy-an-improved-method-for-geographic-masking
#5
Wayne Richter
Geographic information adds a powerful component to environmental epidemiology studies but can compromise subject confidentiality. Although locations are often masked by perturbing spatial coordinates, existing masks do not ensure that the perturbation area contains a sufficient number of valid surrogates to prevent disclosure, nor are they designed to minimize perturbation while maintaining a specified level of privacy. I introduce a new approach to geoprivacy in which real property parcel data with information about land use are used to develop a pool of verified neighbors...
September 20, 2017: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/28929419/high-resolution-mr-imaging-for-dental-impressions-a-feasibility-study
#6
Julian Boldt, Kurt Rottner, Marc Schmitter, Andreas Hopfgartner, Peter Jakob, Ernst-Jürgen Richter, Olga Tymofiyeva
OBJECTIVES: Magnetic resonance imaging is an emerging technology in dental medicine. While low-resolution MRI has especially provided means to examine the temporomandibular joint due to its anatomic inaccessibility, it was the goal of this study to assess whether high-resolution MRI is capable of delivering a dataset sufficiently precise enough to serve as digital impression of human teeth. MATERIALS AND METHODS: An informed and consenting patient in need of dental restoration with fixed partial dentures was chosen as subject...
September 19, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28925560/apremilast-in-psoriasis-a-prospective-real-world-study
#7
I Vujic, R Herman, M Sanlorenzo, C Posch, B Monshi, K Rappersberger, L Richter
BACKGROUND: Apremilast is a novel oral phosphodiesterase-4 inhibitor approved for psoriasis treatment. Randomized trials have documented its efficacy and safety, but data on real-world patients are scarce. OBJECTIVES: We aim to characterize psoriasis patients treated with apremilast in a real-world setting and calculate drug survival as an important measure of efficacy and compliance. METHODS: All psoriasis patients that received apremilast between April 1(st) 2015 and January 19(th) 2017 were evaluated every 4 weeks and we documented: age, weight, height, smoking status, family history of psoriasis, joint involvement, previous treatments, psoriasis area severity index (PASI) scores, and the onset and duration of adverse events (AE)...
September 19, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28925271/-the-results-of-five-years-follow-up-prospective-study-of%C3%A2-vaginal-prolapse-repaired-by-prolift-total-mesh-surgery-or%C3%A2-sacrospinous-fixation
#8
P Kraus, L Krofta, M Krčmář, I Urbánková, O Gojiš, K Grogregin, J Feyereisl
OBJECTIVE: The aim of the study is to compare the results of five years follow-up prospective study of vaginal prolapse repaired by prolift total mesh surgery or sacrospinous fixation. STUDY DESIGN: A single-center prospective, cohort study, in patients with defect grade II and more by POP-Q. SETTING: The Institute for the Care of Mather and Child; 3rd Medical Faculty Charles university, Prague. METHODS: Comparison of the preoperative state and the five years after the operation according POP Q, ICIQ-SF, PISQ 12, VAS...
2017: Ceská Gynekologie
https://www.readbyqxmd.com/read/28921843/potential-proton-and-photon-dose-degradation-in-advanced-head-and-neck-cancer-patients-by-intratherapy-changes
#9
Kristin Stützer, Annika Jakobi, Anna Bandurska-Luque, Steffen Barczyk, Carolin Arnsmeyer, Steffen Löck, Christian Richter
PURPOSE: Evaluation of dose degradation by anatomic changes for head-and-neck cancer (HNC) intensity-modulated proton therapy (IMPT) relative to intensity-modulated photon therapy (IMRT) and identification of potential indicators for IMPT treatment plan adaptation. METHODS: For 31 advanced HNC datasets, IMPT and IMRT plans were recalculated on a computed tomography scan (CT) taken after about 4 weeks of therapy. Dose parameter changes were determined for the organs at risk (OARs) spinal cord, brain stem, parotid glands, brachial plexus, and mandible, for the clinical target volume (CTV) and the healthy tissue outside planning target volume (PTV)...
September 18, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28921373/released-fraction-of-polychlorinated-biphenyls-from-soil-biosolid-system-using-a-leaching-procedure-and-its-comparison-with-bioavailable-fraction-determined-by-wheat-plant-uptake
#10
Lourdes Jachero, Claudio Leiva, Inés Ahumada, Pablo Richter
The bioavailability of polychlorinated biphenyls (PCBs) in soils amended with biosolids was estimated using an aqueous leaching process of the compounds combined with rotating disk sorptive extraction (RDSE), and compared with bioavailability determined through of PCB absorption in wheat plants growing in the same soil-biosolid matrix. The matrices consisted of soil amended with biosolids at doses of 30, 90, and 200 Mg/ha, which increase concomitantly the organic matter content of the matrix. Considering that PCBs were natively absent in both the biosolids and soil used, the compounds were spiked in the biosolids and aged for 10 days...
September 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28920556/the-effects-of-limb-dominance-and-a-short-term-high-intensity-exercise-protocol-on-both-landings-of-the-vertical-drop-jump-implications-for-the-vertical-drop-jump-as-a-screening-tool
#11
Enda F Whyte, Patrick Kennelly, Oliver Milton, Chris Richter, Siobhán O'Connor, Kieran A Moran
The effectiveness of vertical drop jumps (VDJs) to screen for non-contact ACL injuries is unclear. This may be contributed to by discrete point analysis, which does not evaluate patterns of movement. Also, limited research exists on the second landing of VDJs, potential lower limb performance asymmetries and the effect of fatigue. Statistical parametric mapping investigated the main effects of landing, limb dominance and a high intensity, intermittent exercise protocol (HIIP) on VDJ biomechanics. Twenty-two male athletes (21...
September 18, 2017: Sports Biomechanics
https://www.readbyqxmd.com/read/28919567/photoacoustic-imaging-for-maximizing-glioma-resection
#12
Barrett J Anderies, Mithun Sattur, Matthew E Welz, Lissette Urday, Kent R Richter, Erich Umbarger, Bernard R Bendok
No abstract text is available yet for this article.
September 14, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28918792/-dural-arteriovenous-fistula-is-a-rare-but-treatable-cause-of-transverse-myelitis
#13
Julie Richter Hansen, Lars Poulsgaard, Markus Holtmannspötter, Joan Højgaard, Peer Tfeldt-Hansen
This is a case report of a 60-year-old male admitted on suspicion of relapse of idiopathic transverse myelitis (TM), who after further diagnostic workup underwent successful closure of a dural arteriovenous fistula (DAVF). Magnetic resonance imaging in DAVF usually shows longitudinal TM, which, unlike DAVF, is also seen with the more common inflammatory or infectious causes usually showing inflammation in the cerebrospinal fluid. The natural history of DAVF is progressive. Since curable options exist, timely diagnosis is most important...
September 18, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28917789/chemometric-optimization-of-the-extraction-and-derivatization-of-parabens-for-their-determination-in-water-samples-by-rotating-disk-sorptive-extraction-and-gas-chromatography-mass-spectrometry
#14
Mercedes Becerra-Herrera, Valentina Miranda, Daniel Arismendi, Pablo Richter
A combination of rotating disk sorptive extraction (RDSE) using Oasis® HLB as the sorbent phase and gas chromatography mass spectrometry (GC-MS) has been performed for the determination of four of the most widely used parabens: methylparaben, ethylparaben, propylparaben and n-butylparaben. The extraction and derivatization of the analytes in water samples were optimized by using factorial (screening) and Doehlert designs, thus reducing the number of analyses with the concomitant reduction of time, reagents, waste, samples and cost...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28917340/esophageal-dilation-for-eosinophilic-esophagitis-it-s-safe-why%C3%A2-aren-t-we-doing-more-dilations
#15
EDITORIAL
Joel E Richter
No abstract text is available yet for this article.
October 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28917270/cancer-related-fatigue-in-adolescents-and-young-adults-a-systematic-review-of-the-literature
#16
REVIEW
E Nowe, Y Stöbel-Richter, A Sender, K Leuteritz, M Friedrich, K Geue
Adolescents and young adults with cancer (AYA) represent a specific age cohort dealing with the disease in a stage of life characterized by development, upheavals, and establishment. The aim of this study was to point out the state of research on how AYA are affected by cancer-related fatigue (CRF). RESULTS: Twelve articles were included. CRF was found to be higher in AYA than in either of the comparison groups, healthy peers and older cancer patients. Most included studies did not measure CRF with multidimensional, fatigue-specific instruments...
October 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28916263/autophagy-dependent-generation-of-free-fatty-acids-is-critical-for-normal-neutrophil-differentiation
#17
Thomas Riffelmacher, Alexander Clarke, Felix C Richter, Amanda Stranks, Sumeet Pandey, Sara Danielli, Philip Hublitz, Zhanru Yu, Errin Johnson, Tobias Schwerd, James McCullagh, Holm Uhlig, Sten Eirik W Jacobsen, Anna Katharina Simon
Neutrophils are critical and short-lived mediators of innate immunity that require constant replenishment. Their differentiation in the bone marrow requires extensive cytoplasmic and nuclear remodeling, but the processes governing these energy-consuming changes are unknown. While previous studies show that autophagy is required for differentiation of other blood cell lineages, its function during granulopoiesis has remained elusive. Here, we have shown that metabolism and autophagy are developmentally programmed and essential for neutrophil differentiation in vivo...
September 19, 2017: Immunity
https://www.readbyqxmd.com/read/28916132/the-association-between-elevated-blood-lead-levels-and-violent-behavior-during-late-adolescence-the-south-african-birth-to-twenty-plus-cohort
#18
Palesa Nkomo, Angela Mathee, Nisha Naicker, Jacky Galpin, Linda M Richter, Shane A Norris
Epidemiological studies have shown the adverse neuro-behavioral health effects of lead exposure among children, in particular. However, there is lack evidence in this regard from developing countries. The main aim of this study was to assess the association between blood lead levels (BLLs) during early adolescence and violent behavior in late adolescence. Our study sample from the Birth to Twenty Plus cohort in Soweto-Johannesburg, South Africa included 1332 study participants (684 females). BLLs were measured using blood samples collected at age 13years...
September 12, 2017: Environment International
https://www.readbyqxmd.com/read/28915861/informed-decision-making-with-and-for-people-with-dementia-efficacy-of-the-prodecide-education-program-for-legal-representatives-protocol-of-a-randomized-controlled-trial-prodecide-rct
#19
Julia Lühnen, Burkhard Haastert, Ingrid Mühlhauser, Tanja Richter
BACKGROUND: In Germany, the guardianship system provides adults who are no longer able to handle their own affairs a court-appointed legal representative, for support without restriction of legal capacity. Although these representatives only rarely are qualified in healthcare, they nevertheless play decisive roles in the decision-making processes for people with dementia. Previously, we developed an education program (PRODECIDE) to address this shortcoming and tested it for feasibility...
September 15, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28915261/simultaneous-determination-of-3-hydroxypropionic-acid-methylmalonic-acid-and-methylcitric-acid-in-dried-blood-spots-second-tier-lc-ms-ms-assay-for-newborn-screening-of-propionic-acidemia-methylmalonic-acidemias-and-combined-remethylation-disorders
#20
Péter Monostori, Glynis Klinke, Sylvia Richter, Ákos Baráth, Ralph Fingerhut, Matthias R Baumgartner, Stefan Kölker, Georg F Hoffmann, Gwendolyn Gramer, Jürgen G Okun
BACKGROUND AND AIMS: Increased propionylcarnitine levels in newborn screening are indicative for a group of potentially severe disorders including propionic acidemia (PA), methylmalonic acidemias and combined remethylation disorders (MMACBL). This alteration is relatively non-specific, resulting in the necessity of confirmation and differential diagnosis in subsequent tests. Thus, we aimed to develop a multiplex approach for concurrent determination of 3-hydroxypropionic acid, methylmalonic acid and methylcitric acid from the same dried blood spot (DBS) as in primary screening (second-tier test)...
2017: PloS One
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