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https://www.readbyqxmd.com/read/28817271/poly-2-oxazoline-antibiotic-conjugates-with-penicillins
#1
Martin Schmidt, Livia K Bast, Franziska Lanfer, Lena Richter, Elisabeth Hennes, Rana Seymen, Christian Krumm, Joerg C Tiller
Conjugation of antibiotics with polymers is rarely done, but might be a promising alternative to low molecular weight derivatization. The two penicillins PenG and PenV were attached to the end groups of different water-soluble poly(2-oxazoline)s (POx) via their carboxylic acid function. This ester group was shown to be more stable against hydrolysis than the β-lactam ring of the penicillins. The conjugates are still antimicrobially active and up to 20 times more stable against penicillinase catalyzed hydrolysis...
August 17, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28815055/green-lacewings-neuroptera-chrysopidae-are-commonly-associated-with-a-diversity-of-rickettsial-endosymbionts
#2
Michael Gerth, Ronny Wolf, Christoph Bleidorn, Julia Richter, Rebekka Sontowski, Jasmin Unrein, Martin Schlegel, Axel Gruppe
BACKGROUND: Bacterial symbionts transmitted from mothers to offspring are found in the majority of arthropods. Numerous studies have illustrated their wide impact on host biology, such as reproduction, behavior, and physiology One of the most common inherited symbionts is Rickettsia spp. (Alphaproteobacteria, Rickettsiales), which are found in about one-quarter of terrestrial arthropods, as well as in other invertebrates. In insect populations, Rickettsia spp. have been reported to cause reproductive modifications and fecundity-enhancing effects...
2017: Zoological Letters
https://www.readbyqxmd.com/read/28812527/cytokine-concentrations-measured-by-multiplex-assays-in-canine-peripheral-blood-samples
#3
Kristen R Richter, Amirah N Nasr, Angela M Mexas
Cytokines are known to play important roles in a wide range of pathologic conditions spanning all organ systems in every species studied. As our knowledge of the physiology of individual cytokines expands and our ability to measure multiple cytokines in smaller biological samples increases, we gain more insight into the significance and function of each cytokine and the importance of cytokine networks. Previous studies that reported measurements of cytokine concentrations from serum or plasma in dogs with infectious, autoimmune, metabolic, endocrine, and neoplastic diseases yield an appreciation for the complexity of cytokine control and potential applications for cytokine measurements in the diagnosis, prognosis, and therapy of a variety of disease conditions...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28810079/lc-esi-ms-ms-determination-of-4-methylpyrazole-in-dog-plasma-and-its-application-to-a-pharmacokinetic-study-in-dogs
#4
Devaraj V Chandrasekhar, Suresh P S, Sreekanth Dittakavi, Rakesh A Hiremath, Ravi Kanth Bhamidipati, Wolfgang Richter, Nuggehally R Srinivas, Ramesh Mullangi
A simple, specific, sensitive and rapid LC-ESI-MS/MS method has been developed and validated for the quantification of 4-methylpyrazole in dog plasma using N-methylnicotinamide-d4 as an internal standard (IS) as per regulatory guideline.s Sample preparation was accomplished through a simple protein precipitation. Chromatographic separation of 4-methylpyrazole and the IS was performed on a monolithic (Chromolith RP-18e) column using an isocratic mobile phase comprising 0.2% formic acid in water and acetonitrile (20:80, v/v) at a flow rate of 1...
August 15, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28809125/post-chemotherapy-perforation-in-cats-with-discrete-intermediate-or-large-cell-gastrointestinal-lymphoma
#5
Zachary Crouse, Brenda Phillips, Andi Flory, Jennifer Mahoney, Keith Richter, Linda Kidd
Objectives Gastrointestinal (GI) perforation is a well-described complication of GI lymphoma in people, commonly occurring within days of initiation of chemotherapy. There are no studies documenting the prevalence of GI perforation in cats with intermediate- or large-cell GI lymphoma or whether it is associated with induction of chemotherapy. The objectives of this study were to document the prevalence and timing of post-chemotherapy perforation in cats with discrete GI masses caused by intermediate- or large-cell lymphoma...
August 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28807645/a-behavioral-weight-loss-program-and-non-urinary-incontinence-lower-urinary-tract-symptoms-in-overweight-and-obese-women-with-urinary-incontinence-a-secondary-data-analysis-of-the-program-to-reduce-incontinence-by-diet-and-exercise-pride
#6
Benjamin N Breyer, Jennifer M Creasman, Holly E Richter, Deborah Myers, Kathryn L Burgio, Rena R Wing, Delia Smith West, John W Kusek, Leslee L Subak
AIMS: To determine whether a behavioral weight reduction intervention improves non-urinary incontinence (UI) lower urinary tract storage symptoms (LUTS) including urinary frequency, nocturia, urgency, at 6 months compared to a structured education program (control group) among overweight and obese women with UI. METHODS: The Program to Reduce Incontinence by Diet and Exercise (PRIDE) was a randomized clinical trial of 338 overweight or obese women with UI. Participants were randomized to 6-month behavioral weight loss intervention (N=226) or control (N=112)...
August 11, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28807145/a-benzothiadiazine-derivative-and-methylprednisolone-are-novel-and-selective-activators-of-transient-receptor-potential-canonical-5-trpc5-channels
#7
Holger Beckmann, Julia Richter, Kerstin Hill, Nicole Urban, Horst Lemoine, Michael Schaefer
The transient receptor potential canonical channel 5 (TRPC5) is a Ca(2+)-permeable ion channel, which is predominantly expressed in the brain. TRPC5-deficient mice exhibit a reduced innate fear response and impaired motor control. In addition, outgrowth of hippocampal and cerebellar neurons is retarded by TRPC5. However, pharmacological evidence of TRPC5 function on cellular or organismic levels is sparse. Thus, there is still a need for identifying novel and efficient TRPC5 channel modulators. We, therefore, screened compound libraries and identified the glucocorticoid methylprednisolone and N-[3-(adamantan-2-yloxy)propyl]-3-(6-methyl-1,1-dioxo-2H-1λ(6),2,4-benzothiadiazin-3-yl)propanamide (BTD) as novel TRPC5 activators...
September 2017: Cell Calcium
https://www.readbyqxmd.com/read/28806908/changing-the-default-for-tobacco-cessation-treatment-in-an-inpatient-setting-study-protocol-of-a-randomized-controlled-trial
#8
Babalola Faseru, Edward F Ellerbeck, Delwyn Catley, Byron J Gajewski, Taneisha S Scheuermann, Theresa I Shireman, Laura M Mussulman, Niaman Nazir, Terry Bush, Kimber P Richter
BACKGROUND: Most health care providers do not treat tobacco dependence routinely. This may in part be due to the treatment "default." Current treatment guidelines recommend that providers (1) ask patients if they are willing to quit and (2) provide cessation-focused medications and counseling only to smokers who state that they are willing to quit. The default is that patients have to "opt in" to receive cessation assistance: providers ask smokers if they are willing to quit, and only offer medications and cessation support to those who say "yes...
August 14, 2017: Trials
https://www.readbyqxmd.com/read/28806531/tidal-carbon-dioxide-as-a-prognostic-feature-in-inoperable-chronic-thromboembolic-pulmonary-hypertension
#9
Manuel J Richter, Khodr Tello, Katrin Milger, Hossein A Ghofrani, Henning Gall
No abstract text is available yet for this article.
August 14, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28806133/autophagy-dictates-metabolism-and-differentiation-of-inflammatory-immune-cells
#10
Thomas Riffelmacher, Felix Clemens Richter, Anna Katharina Simon
The role of macroautophagy/autophagy, a conserved lysosomal degradation pathway, during cellular differentiation has been well studied over the last decade. Particularly, evidence for its role during immune cell differentiation is growing. Despite the description of a variety of dramatic immune phenotypes in tissue-specific autophagy knockout models, the underlying mechanisms are still under debate. One of the proposed mechanisms is the impact of autophagy on the altered metabolic states during immune cell differentiation...
August 14, 2017: Autophagy
https://www.readbyqxmd.com/read/28806088/giant-valley-isospin-conductance-oscillations-in-ballistic-graphene
#11
Clevin Handschin, Péter Makk, Peter Rickhaus, Romain Maurand, Kenji Watanabe, Takashi Taniguchi, Klaus Richter, Ming-Hao Liu, Christian Schönenberger
At high magnetic fields the conductance of graphene is governed by the half-integer quantum Hall effect. By local electrostatic gating a p-n junction perpendicular to the graphene edges can be formed, along which quantum Hall channels copropagate. It has been predicted by Tworzidło and co-workers that if only the lowest Landau level is filled on both sides of the junction, the conductance is determined by the valley (isospin) polarization at the edges and by the width of the flake. This effect remained hidden so far due to scattering between the channels copropagating along the p-n interface (equilibration)...
August 17, 2017: Nano Letters
https://www.readbyqxmd.com/read/28805284/interaction-of-the-n-terminal-tandem-domains-of-hnrnp-ll-with-the-bcl2-promoter-i-motif-dna-sequence
#12
Harald Schwalbe, Lauris Lannes, Phoebe Young, Christian Richter, Nina Morgner
The human genome contains GC-rich sequences able to form tetraplex secondary structures known as G-quadruplex and i-motif. Such sequences are notably present in the promoter region of oncogenes and are proposed to function as regulatory elements of the gene expression. The P1 promoter of BCL2 contains a 39-mer C-rich sequence (Py39wt) which can fold into a hairpin or an i-motif in a pH-dependent manner in vitro. The protein hnRNP LL was identified to recognise the i-motif over the hairpin conformation and act as an activating transcription factor...
August 14, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28805281/efficacy-and-safety-of-a-fixed-dose-combination-of-ibuprofen-and-caffeine-in-the-management-of-moderate-to-severe-dental-pain-after-third-molar-extraction
#13
T Weiser, E Richter, A Hegewisch, D D Muse, R Lange
BACKGROUND: Ibuprofen is an effective analgesic treatment with a ceiling effect at doses above 400 mg. This study compared the combination of ibuprofen 400 mg and caffeine 100 mg with ibuprofen 400 mg monotherapy, caffeine and placebo in the analgesic treatment of moderate to severe acute dental pain following third molar extraction. METHODS: Phase III, active-/placebo-controlled, double-blind, single-centre, two-stage, parallel-group study in adult patients with at least moderate baseline pain intensity...
August 14, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28805046/electroenhanced-antimicrobial-coating-based-on-conjugated-polymers-with-covalently-coupled-silver-nanoparticles-prevents-staphylococcus-aureus-biofilm-formation
#14
Salvador Gomez-Carretero, Rolf Nybom, Agneta Richter-Dahlfors
The incidence of hospital-acquired infections is to a large extent due to device-associated infections. Bacterial attachment and biofilm formation on surfaces of medical devices often act as seeding points of infection. To prevent such infections, coatings based on silver nanoparticles (AgNPs) are often applied, however with varying clinical success. Here, the traditional AgNP-based antibacterial technology is reimagined, now forming the base for an electroenhanced antimicrobial coating. To integrate AgNPs in an electrically conducting polymer layer, a simple, yet effective chemical strategy based on poly(hydroxymethyl 3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT-MeOH:PSS) and (3-aminopropyl)triethoxysilane is designed...
August 14, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28803824/the-clinical-spectrum-of-hepatic-manifestations-in-chronic-lymphocytic-leukemia
#15
REVIEW
Natalia Kreiniz, Ofrat Beyar Katz, Aaron Polliack, Tamar Tadmor
Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world, characterized by the presence of long-lived circulating leukemic cells in the peripheral blood that may infiltrate all organs, particularly those of the reticulo-endothelial system. Liver enlargement and elevation of liver enzymes related to specific involvement by the underlying disease are well-recognized features in these patients. In CLL, the differential diagnosis of liver disorders is broad and includes liver infiltration by leukemic cells, immunologic manifestations associated with CLL, primary and secondary hepatic malignancies, drug-induced hepatotoxicity, infections, and Richter transformation...
July 23, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28803752/optimal-dose-timing-and-ratio-of-blood-products-in-massive-transfusion-results-from-a-systematic-review
#16
REVIEW
Zoe K McQuilten, Gemma Crighton, Susan Brunskill, Jessica K Morison, Tania H Richter, Neil Waters, Michael F Murphy, Erica M Wood
Optimal dose, timing and ratio to red blood cells (RBC) of blood component therapy (fresh frozen plasma [FFP], platelets, cryoprecipitate or fibrinogen concentrate) to reduce morbidity and mortality in critically bleeding patients requiring massive transfusion is unknown. We performed a systematic review for randomized controlled trials (RCT) in MEDLINE, The Cochrane Library, Embase, CINAHL, PubMed the Transfusion Evidence Library and using multiple clinical trials registries to 21 February 2017. Sixteen RCTs were identified: six completed (five in adult trauma patients, one pediatric burn patients) and ten ongoing trials...
July 6, 2017: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/28801452/correction-for-nechama-et-al-an-unusual-two-step-control-of-cpeb-destruction-by-pin1
#17
Morris Nechama, Chien-Ling Lin, Joel D Richter
No abstract text is available yet for this article.
September 1, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28801324/mechanical-thrombectomy-for-repeated-cerebral-tumor-embolism-from-a-thoracic-sarcomatoid-carcinoma
#18
Raoul Pop, Dan Mihoc, Monica Manisor, Johann Sebastian Richter, Veronique Lindner, Ralf Janssen-Langenstein, Mihaela Simu, Valerie Wolff, Remy Beaujeux
Cerebral embolism originating from intracardiac tumors represents a rare cause of stroke and has been documented in both adult and pediatric populations. We present a patient recently diagnosed with a right pulmonary hilum tumor, invading the pulmonary veins and the left atrium. Two consecutive episodes of large cerebral vessel occlusion in separate vascular territories occurred in the same day and were treated by mechanical thrombectomy. Embolic material retrieved on both occasions contained tumor fragments with peripheral endothelialization...
August 11, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28800190/reductive-eliminations-from-diarylpalladium-ii-complexes-a-combined-experimental-and-computational-investigation
#19
Tobias Gensch, Robert Thoran, Nils Richter, Hans-Joachim Knölker
We have investigated the diverse mechanisms for the reductive elimination of biaryl compounds from diarylpalladium(II) complexes with a tetradentate ligand in a combined experimental and computational study. At least four distinct chemical triggers with specific regioselectivity exist for this elimination. Heating of the complexes in inert solvents (e.g., para-xylene) reveals their relatively high thermal stability as reflected by a very high barrier for a unimolecular reductive elimination. In contrast, electron-donor ligands like triphenylphosphine induce a facile reductive elimination via twofold associative ligand exchange as confirmed by kinetic experiments which are in excellent agreement with the computational results...
August 11, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28800136/feathermoss-and-epiphytic-nostoc-cooperate-differently-expanding-the-spectrum-of-plant-cyanobacteria-symbiosis
#20
Denis Warshan, Josh L Espinoza, Rhona K Stuart, R Alexander Richter, Sea-Yong Kim, Nicole Shapiro, Tanja Woyke, Nikos C Kyrpides, Kerrie Barry, Vasanth Singan, Erika Lindquist, Charles Ansong, Samuel O Purvine, Heather M Brewer, Philip D Weyman, Christopher L Dupont, Ulla Rasmussen
Dinitrogen (N2)-fixation by cyanobacteria in symbiosis with feathermosses is the primary pathway of biological nitrogen (N) input into boreal forests. Despite its significance, little is known about the cyanobacterial gene repertoire and regulatory rewiring needed for the establishment and maintenance of the symbiosis. To determine gene acquisitions and regulatory changes allowing cyanobacteria to form and maintain this symbiosis, we compared genomically closely related symbiotic-competent and -incompetent Nostoc strains using a proteogenomics approach and an experimental set up allowing for controlled chemical and physical contact between partners...
August 11, 2017: ISME Journal
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