keyword
MENU ▼
Read by QxMD icon Read
search

Richter

keyword
https://www.readbyqxmd.com/read/29342186/doxorubicin-provoked-increase-of-mitotic-activity-and-concomitant-drain-of-g0-pool-in-therapy-resistant-be-2-c-neuroblastoma
#1
Isabell Hultman, Linnea Haeggblom, Ingvild Rognmo, Josefin Jansson Edqvist, Evelina Blomberg, Rouknuddin Ali, Lottie Phillips, Bengt Sandstedt, Per Kogner, Shahrzad Shirazi Fard, Lars Ährlund-Richter
In this study chemotherapy response in neuroblastoma (NB) was assessed for the first time in a transplantation model comprising non-malignant human embryonic microenvironment of pluripotent stem cell teratoma (PSCT) derived from diploid bona fide hESC. Two NB cell lines with known high-risk phenotypes; the multi-resistant BE(2)-C and the drug sensitive IMR-32, were transplanted to the PSCT model and the tumour growth was exposed to single or repeated treatments with doxorubicin, and thereafter evaluated for cell death, apoptosis, and proliferation...
2018: PloS One
https://www.readbyqxmd.com/read/29341730/polymer-chain-conformation-and-dynamical-confinement-in-a-model-one-component-nanocomposite
#2
C Mark, O Holderer, J Allgaier, E Hübner, W Pyckhout-Hintzen, M Zamponi, A Radulescu, A Feoktystov, M Monkenbusch, N Jalarvo, D Richter
We report a neutron-scattering investigation on the structure and dynamics of a single-component nanocomposite based on SiO_{2} particles that were grafted with polyisoprene chains at the entanglement limit. By skillful labeling, we access both the monomer density in the corona as well as the conformation of the grafted chains. While the corona profile follows a r^{-1} power law, the conformation of a grafted chain is identical to that of a chain in a reference melt, implying a high mutual penetration of the coronas from different particles...
July 28, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29341236/induced-earthquakes-from-long-term-gas-extraction-in-groningen-the-netherlands-statistical-analysis-and-prognosis-for-acceptable-risk-regulation
#3
Charles Vlek
Recently, growing earthquake activity in the northeastern Netherlands has aroused considerable concern among the 600,000 provincial inhabitants. There, at 3 km deep, the rich Groningen gas field extends over 900 km2 and still contains about 600 of the original 2,800 billion cubic meters (bcm). Particularly after 2001, earthquakes have increased in number, magnitude (M, on the logarithmic Richter scale), and damage to numerous buildings. The man-made nature of extraction-induced earthquakes challenges static notions of risk, complicates formal risk assessment, and questions familiar conceptions of acceptable risk...
January 16, 2018: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/29339528/gonadal-function-in-adult-male-patients-with-congenital-adrenal-hyperplasia
#4
Manon Engels, Katharina Gehrmann, Henrik Falhammar, Emma A Webb, Anna Nordenstrom, Fred Sweep, Paul N Span, Antonius Eduard van Herwaarden, Julia Rohayem, Annette Richter-Unruh, Claire Bouvattier, Birgit Koehler, Barbara B Kortmann, Wiebke Arlt, Nel Roeleveld, Nicole Reisch, Nike Stikkelbroeck, Hedi L Claahsen-van der Grinten
CONTEXT: Current knowledge on gonadal function in Congenital Adrenal Hyperplasia (CAH) is mostly limited to single center/country studies enrolling small patient numbers. Overall data indicate that gonadal function can be compromised in men with CAH. OBJECTIVE: To determine gonadal function in men with CAH within the European "dsd-LIFE" cohort. DESIGN: Cross-sectional clinical outcome study, including retrospective data from medical records...
January 16, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29338915/the-significance-of-avoiding-household-food-waste-a-means-end-chain-approach
#5
Beate Richter, Wolfgang Bokelmann
Many humans suffer from hunger, while edible food is discarded. This study aims at showing the importance of avoiding food waste in households and its causes by applying the means-end-chain analysis. Additional the means-end-chain approach should be examined in how far the method is suitable to get insights towards this topic. Consumer backgrounds in terms of feelings and attitudes regarding food waste should be shown, with the particular question why food waste personally is important. The data collection occurred utilizing the hard laddering method within a quantitative online survey...
January 12, 2018: Waste Management
https://www.readbyqxmd.com/read/29338855/vitrified-blastocyst-transfer-cycles-with-the-use-of-only-vaginal-progesterone-replacement-with-endometrin-have-inferior-ongoing-pregnancy-rates-results-from-the-planned-interim-analysis-of-a-three-arm-randomized-controlled-noninferiority-trial
#6
Kate Devine, Kevin S Richter, Eric A Widra, Jeffrey L McKeeby
OBJECTIVE: To assess the noninferiority of vaginal P (Endometrin) compared with daily intramuscular P for replacement in programmed vitrified-warmed blastocyst transfer cycles and to assess the noninferiority of vaginal P in combination with intramuscular progesterone every third day compared with daily intramuscular P. DESIGN: Three-arm randomized controlled noninferiority study. To enable early recognition of inferiority if present, an a priori interim analysis was planned and completed once ongoing pregnancy data were available for 50% of the total enrollment goal...
January 12, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29335742/stand-alone-emollient-treatment-reduces-flares-after-discontinuation-of-topical-steroid-treatment-in-atopic-dermatitis-a-double-blind-randomized-vehicle-controlled-left-right-comparison-study
#7
Irena Angelova-Fischer, Frank Rippke, Daniel Richter, Alexander Filbry, Craig Arrowitz, Teresa Weber, Tobias W Fischer, Detlef Zillikens
Prevention of flares is a main goal in the long-term treatment of atopic dermatitis (AD). This study investigated the efficacy of a water-in-oil emollient, containing licochalcone A, omega-6-fatty acids, ceramide 3 and glycerol, for prevention of flares in adults with mild to moderately severe AD, who had been treated with topical steroids, which had led to clearing of the inflammatory lesions and had been discontinued prior to inclusion. The study was a 12-week, double-blind, randomized, vehicle-controlled, left-right comparison test with the number of relapses, defined as re-occurrence of erythema for at least 3 consecutive days, considered the primary outcome...
January 16, 2018: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29335389/checklist-in-colorectal-surgery-proposal-of-experts-of-the-polish-club-of-coloproctology-and-national-consultant-in-general-surgery
#8
Tomasz Banasiewicz, Łukasz Krokowicz, Piotr Richter, Adam Dziki, Piotr Krokowicz, Zbigniew Lorenc, Marek Szczepkowski, Michał Drews, Grzegorz Wallner
A checklist is a collection of information that helps reduce the risk of failure due to limitations in human memory and attention. In surgery, the first Surgical Safety Checklist (SSC), created under the supervision of WHO (World Health Organization), was established in 2007 and covers three stages related to the patient's stay in the operating theater and operation: 1. Prior to initiation (induction) of anesthesia; 2. before cutting the skin; 3. before the patient leaves the operating room Colorectal surgery is particularly at high risk for complications and relatively high mortality...
December 30, 2017: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/29334381/the-molecular-basis-of-subtype-selectivity-of-human-kinin-g-protein-coupled-receptors
#9
Lisa Joedicke, Jiafei Mao, Georg Kuenze, Christoph Reinhart, Tejaswi Kalavacherla, Hendrik R A Jonker, Christian Richter, Harald Schwalbe, Jens Meiler, Julia Preu, Hartmut Michel, Clemens Glaubitz
G-protein-coupled receptors (GPCRs) are the most important signal transducers in higher eukaryotes. Despite considerable progress, the molecular basis of subtype-specific ligand selectivity, especially for peptide receptors, remains unknown. Here, by integrating DNP-enhanced solid-state NMR spectroscopy with advanced molecular modeling and docking, the mechanism of the subtype selectivity of human bradykinin receptors for their peptide agonists has been resolved. The conserved middle segments of the bound peptides show distinct conformations that result in different presentations of their N and C termini toward their receptors...
January 15, 2018: Nature Chemical Biology
https://www.readbyqxmd.com/read/29332973/metabologenomics-of-phaeochromocytoma-and-paraganglioma-an-integrated-approach-for-personalised-biochemical-and-genetic-testing
#10
REVIEW
Graeme Eisenhofer, Barbara Klink, Susan Richter, Jacques Wm Lenders, Mercedes Robledo
The tremendous advances over the past two decades in both clinical genetics and biochemical testing of chromaffin cell tumours have led to new considerations about how these aspects of laboratory medicine can be integrated to improve diagnosis and management of affected patients. With germline mutations in 15 genes now identified to be responsible for over a third of all cases of phaeochromocytomas and paragangliomas, these tumours are recognised to have one of the richest hereditary backgrounds among all neoplasms...
April 2017: Clinical Biochemist. Reviews
https://www.readbyqxmd.com/read/29332341/association-of-the-combined-parameters-including-the-frequency-of-primary-cilia-cd8-tumor-infiltrating-lymphocytes-and-pd-1-expression-with-the-outcome-in-intestinal-cancer
#11
Josef Dvorak, Dimitar Hadzi Nikolov, Ladislav Dusek, Alzbeta Filipova, Igor Richter, David Buka, Ales Ryska, Jaroslav Mokry, Stanislav Filip, Bohuslav Melichar, Tomas Buchler, Jitka Abrahamova
PURPOSE: Primary cilium (PC) is considered to be a functional homologue of the immune synapse. Microtubule structures, PC of cancer associated fibroblasts and immune synapses between cytotoxic CD8+ tumor infiltrating lymphocytes (TILs) and cancer cells, are regularly found in varying amounts in the microenvironment of solid tumors. The purpose of this study was to find out the potential association and combined prognostic significance of the frequency of PC, PD-1 and CD8+ TILs in patients with intestinal cancer...
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29331313/predictors-of-exacerbation-risk-and-response-to-budesonide-in-patients-with-chronic-obstructive-pulmonary-disease-a-post-hoc-analysis-of-three-randomised-trials
#12
Mona Bafadhel, Stefan Peterson, Miguel A De Blas, Peter M Calverley, Stephen I Rennard, Kai Richter, Malin Fagerås
BACKGROUND: The peripheral blood eosinophil count might help identify those patients with chronic obstructive pulmonary disease (COPD) who will experience fewer exacerbations when taking inhaled corticosteroids (ICS). Previous post-hoc analyses have proposed eosinophil cutoffs that are both arbitrary and limited in evaluating complex interactions of treatment response. We modelled eosinophil count as a continuous variable to determine the characteristics that determine both exacerbation risk and clinical response to ICS in patients with COPD...
January 10, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29330508/picometer-polar-atomic-displacements-in-strontium-titanate-determined-by-resonant-x-ray-diffraction
#13
Carsten Richter, Matthias Zschornak, Dmitri Novikov, Erik Mehner, Melanie Nentwich, Juliane Hanzig, Semën Gorfman, Dirk C Meyer
Physical properties of crystalline materials often manifest themselves as atomic displacements either away from symmetry positions or driven by external fields. Especially the origin of multiferroic or magnetoelectric effects may be hard to ascertain as the related displacements can reach the detection limit. Here we present a resonant X-ray crystal structure analysis technique that shows enhanced sensitivity to minute atomic displacements. It is applied to a recently found crystalline modification of strontium titanate that forms in single crystals under electric field due to oxygen vacancy migration...
January 12, 2018: Nature Communications
https://www.readbyqxmd.com/read/29328290/design-of-narrowband-bragg-spectral-filters-in-subwavelength-grating-metamaterial-waveguides
#14
Jiří Čtyroký, Juan Gonzalo Wangüemert-Pérez, Pavel Kwiecien, Ivan Richter, Ján Litvik, Jens H Schmid, Íñigo Molina-Fernández, Alejandro Ortega-Moñux, Milan Dado, Pavel Cheben
Properties of reflection and transmission spectral filters based on Bragg gratings in subwavelength grating (SWG) metamaterial waveguides on silicon-on-insulator platform have been analyzed using proprietary 2D and 3D simulation tools based on Fourier modal method and the coupled-mode theory. We also demonstrate that the coupled Bloch mode theory can be advantageously applied to design of Bragg gratings in SWG waveguides. By combining different techniques, including judiciously positioning silicon loading segments within the evanescent field of the SWG waveguide and making use of its dispersion properties, it is possible to attain sub-nanometer spectral bandwidths for both reflection and transmission filters in the wavelength range of 1550 nm while keeping minimum structural features of the filters as large as 100 nm...
January 8, 2018: Optics Express
https://www.readbyqxmd.com/read/29324595/association-of-pharmacologic-treatment-of-urgency-urinary-incontinence-with-sleep-quality-and-daytime-sleepiness
#15
Qurratul A Warsi, Alison J Huang, Rachel Hess, Lily A Arya, Holly E Richter, Catherine S Bradley, Rebecca G Rogers, Deborah L Myers, Karen C Johnson, William D Winkelman, W Thomas Gregory, Stephen R Kraus, Michael Schembri, Jeanette S Brown, Katie L Stone, Leslee L Subak
OBJECTIVE: To evaluate the association between pharmacologic therapy for urgency urinary incontinence (UUI) and sleep quality. METHODS: We conducted a planned secondary data analysis of sleep outcomes in a previously conducted multicenter, double-blind, 12-week randomized trial of pharmacologic therapy for urgency-predominant incontinence among community-dwelling women self-diagnosed using the 3-Incontinence Questions questionnaire. Participants (N=645) were assigned randomly to 4-8 mg antimuscarinic therapy daily or placebo...
January 9, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29323685/coarsening-dynamics-of-ferromagnetic-granular-networks-experimental-results-and-simulations
#16
Armin Kögel, Pedro A Sánchez, Robin Maretzki, Tom Dumont, Elena S Pyanzina, Sofia S Kantorovich, Reinhard Richter
We investigate the phase separation of a shaken mixture of glass and magnetised steel spheres after a sudden quench of the shaker amplitude. After quenching, transient networks of steel spheres emerge in the experiment. For the developing network clusters we estimate the number of spheres in them, and the characteristic path lengths. We find that both quantities follow a log-normal distribution function. Moreover, we study the temporal evolution of the networks. In the sequence of snapshots we observe an initial regime, where the network incubates, followed by a temporal regime where network structures are elongated and broken, and finally a regime where the structures have relaxed to compact clusters of rounded shapes...
January 11, 2018: Soft Matter
https://www.readbyqxmd.com/read/29323659/production-deformation-and-mechanical-investigation-of-magnetic-alginate-capsules
#17
Elena Zwar, Andre Kemna, Lena Richter, Patrick Degen, Heinz Rehage
In this article we investigated the deformation of alginate capsules in magnetic fields. The sensitivity to magnetic forces was realised by encapsulating an oil in water emulsion, where the oil droplets contained dispersed magnetic nanoparticles. We solved calcium ions in the aqueous emulsion phase, which act as crosslinking compounds for forming thin layers of alginate membranes. This encapsulating technique allows the production of flexible capsules with an emulsion as the capsule core. It is important to mention that the magnetic nanoparticles were stable and dispersed throughout the complete process, which is an important difference to most magnetic alginate-based materials...
January 11, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29322862/feasibility-of-developing-a-passive-sampler-for-sampling-heavy-metals-in-bmps-for-stormwater-runoff-management
#18
Yueqin Dou, Mitch Klein, Tian C Zhang, John Stansbury, Massoum Moussavi, Dana L Richter-Egger, Jing Zeng
Structural Best Management Practices (BMPs) have been used for stormwater treatment and management for several decades. How to monitor these BMPs performance reliably and economically is a challenge. This paper reports feasibility of developing a flow through passive sampler (PS) based on Amberlite IRC748 ion exchange resin operated in kinetic regime for sampling heavy metals in BMPs (infiltration systems) for stormwater treatment and management. Tests were conducted using batch reactors and laboratory-scale BMPs (bioretention cells)...
January 11, 2018: Environmental Technology
https://www.readbyqxmd.com/read/29321651/auditory-neural-activity-in-congenitally-deaf-mice-induced-by-infrared-neural-stimulation
#19
Xiaodong Tan, Israt Jahan, Yingyue Xu, Stuart Stock, Changyow Claire Kwan, Carmen Soriano, Xianghui Xiao, Jaime García-Añoveros, Bernd Fritzsch, Claus-Peter Richter
To determine whether responses during infrared neural stimulation (INS) result from the direct interaction with spiral ganglion neurons (SGNs), we tested three genetically modified deaf mouse models: Atoh1-cre; Atoh1 f/f (Atoh1 conditional knockout, CKO), Atoh1-cre; Atoh1 f/kiNeurog1 (Neurog1 knockin, KI), and the Vglut3 knockout (Vglut3 -/-) mice. All animals were exposed to tone bursts and clicks up to 107 dB (re 20 µPa) and to INS, delivered with a 200 µm optical fiber. The wavelength (λ) was 1860 nm, the radiant energy (Q) 0-800 µJ/pulse, and the pulse width (PW) 100-500 µs...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29320704/extracellular-vesicles-provide-a-means-for-tissue-crosstalk-during-exercise
#20
Martin Whitham, Benjamin L Parker, Martin Friedrichsen, Janne R Hingst, Marit Hjorth, William E Hughes, Casey L Egan, Lena Cron, Kevin I Watt, Rhiannon P Kuchel, Navind Jayasooriah, Emma Estevez, Tim Petzold, Catherine M Suter, Paul Gregorevic, Bente Kiens, Erik A Richter, David E James, Jørgen F P Wojtaszewski, Mark A Febbraio
Exercise stimulates the release of molecules into the circulation, supporting the concept that inter-tissue signaling proteins are important mediators of adaptations to exercise. Recognizing that many circulating proteins are packaged in extracellular vesicles (EVs), we employed quantitative proteomic techniques to characterize the exercise-induced secretion of EV-contained proteins. Following a 1-hr bout of cycling exercise in healthy humans, we observed an increase in the circulation of over 300 proteins, with a notable enrichment of several classes of proteins that compose exosomes and small vesicles...
January 9, 2018: Cell Metabolism
keyword
keyword
90114
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"