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https://www.readbyqxmd.com/read/28807531/absent-cardiac-and-muscle-sympathetic-nerve-activities-involvement-in-ross-syndrome-a-follow-up-study
#1
E Fileccia, R Liguori, P Cortelli, V Donadio
PURPOSE: Ross syndrome (RS) is characterized by selective involvement of post-ganglionic skin sympathetic nerve fibres. We report a follow-up study in 4 patients to clarify whether in RS autonomic dysfunction spreads affecting also cardiovascular system. METHODS: The patients underwent cardiovascular reflexes (CVR) and microneurography recording of muscle sympathetic nerve activity (MSNA) for a follow-up mean period of 5years. RESULTS: CVR and MSNA were normal at baseline and unchanged over the follow-up...
August 9, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28806496/anterior-superior-alveolar-nerve-injury-after-extended-endoscopic-medial-maxillectomy-a-preclinical-study-to-predict-neurological-morbidity
#2
Alberto Schreiber, Davide Mattavelli, Marco Ferrari, Vittorio Rampinelli, Davide Lancini, Marco Ravanelli, Giacomo Bertazzoni, Luigi Fabrizio Rodella, Barbara Buffoli, Francesco Doglietto, Piero Nicolai
BACKGROUND: Endoscopic medial maxillectomies (EMMs) are used to optimize exposure of the maxillary sinus and retromaxillary areas. Although in type D EMM (Sturmann-Canfield procedure) the anterior superior alveolar nerve (ASAN) is always at risk of injury, only 29% of patients complained of alveolar process and dental anesthesia. The purpose of this anatomical study is to assess the neural anastomotic network of the ASAN (ASAN-NAN) and describe different extensions of type D EMMs in a preclinical setting...
August 14, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28803751/insulin-prevents-aberrant-mitochondrial-phenotype-in-sensory-neurons-of-type-1-diabetic-rats
#3
Mohamad-Reza Aghanoori, Darrell R Smith, Subir Roy Chowdhury, Mohammad Golam Sabbir, Nigel A Calcutt, Paul Fernyhough
Diabetic neuropathy affects approximately 50% of diabetic patients. Down-regulation of mitochondrial gene expression and function has been reported in both human tissues and in dorsal root ganglia (DRG) from animal models of type 1 and type 2 diabetes. We hypothesized that loss of direct insulin signaling in diabetes contributes to loss of mitochondrial function in DRG neurons and to development of neuropathy. Sensory neurons obtained from age-matched adult control or streptozotocin (STZ)-induced type 1 diabetic rats were cultured with or without insulin before determining mitochondrial respiration and expression of mitochondrial respiratory chain and insulin signaling-linked proteins...
August 10, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28767480/combined-selective-nerve-blockade-and-local-infiltration-analgesia-in-a-total-shoulder-arthroplasty-patient-with-chronic-pain-and-severe-restrictive-lung-disease-a-case-report
#4
Jason K Panchamia, David A Olsen, Joaquin Sanchez-Sotelo, Adam W Amundson
Interscalene brachial plexus block is considered the most complete postoperative analgesia after total shoulder arthroplasty. Interscalene brachial plexus block-induced ipsilateral hemidiaphragmatic paralysis may not be tolerated in patients with preexisting pulmonary disease. Selective distal nerve blocks avoid the risk of phrenic nerve block; however, they may provide incomplete analgesia to the glenohumeral joint. We report a case of combined selective suprascapular and axillary nerve blockade in combination with local infiltration analgesia in a patient with severe lung disease undergoing total shoulder arthroplasty...
August 1, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28763413/ultrasound-guided-motor-sparing-knee-blocks-for-postoperative-analgesia-following-total-knee-arthroplasty-a-randomized-blinded-study
#5
Olawale A Sogbein, Rakesh V Sondekoppam, Dianne Bryant, David F Johnston, Edward M Vasarhelyi, Steven MacDonald, Brent Lanting, Sugantha Ganapathy, James L Howard
BACKGROUND: Pain following total knee arthroplasty (TKA) is often severe and can inhibit rehabilitation. Motor-sparing analgesic techniques such as periarticular infiltrations and adductor canal blocks have been popularized for knee analgesia since they preserve motor strength and permit early mobilization. Our primary objective was to compare the duration of analgesia from motor-sparing blocks with that of a standard periarticular infiltration. We used the time to first rescue analgesia as the end point...
August 2, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28759949/is-saphenous-nerve-radio-frequency-an-effective-treatment-for-advanced-gonarthrosis-in-elders-with-cardiac-comorbidity
#6
Pınar Karaca Baysal, Özgür Baysal, Atakan Erkılınç, Mustafa Emre Gürcü, Ayşe Nur Yeksan, Birzat Emre Gölboyu, Mürsel Ekinci
BACKGROUND: Pulsed radiofrequency (PRF) used for knee pain originating from osteoarthritis is one of these methods. OBJECTIVES: The aim of the study was to evaluate the knee functional status and pain palliation following the application of pulse radiofrequency in patients with cardiac comorbid disease who were diagnosed with advanced stage osteoarthritis. METHODS: Thirty-eight patients with high surgical risk having cardiac comorbidities with grade 3-4 gonarthrosis according to the Kellgren-Lawrence classification were retrospectively analyzed...
July 14, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28757835/pain-relief-following-thoracic-surgical-procedures-a-literature-review-of-the-uncommon-techniques
#7
REVIEW
Tariq Alzahrani
Thoracic surgical procedures can be either thoracotomy or thoracoscopy. In thoracotomy, the incision could be either muscle-cutting or muscle-sparing incision. The posterolateral thoracotomy incision is used for most general thoracic surgical procedures. This incision, which involves division of the latissimus dorsi and serratus anterior muscles, affords excellent exposure of the thoracic cavity. However, it is associated with significant morbidity, including impaired pulmonary function, postoperative chest pain, and restricted arm and shoulder movement...
July 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28753236/blood-spinal-cord-barrier-breakdown-and-pericyte-deficiency-in-peripheral-neuropathy
#8
Reine-Solange Sauer, Juliane Kirchner, Shaobing Yang, Liu Hu, Mathias Leinders, Claudia Sommer, Alexander Brack, Heike L Rittner
The blood-spinal cord barrier (BSCB) prevents leakage of molecules, such as pronociceptive mediators, into the spinal cord, but its role in the pathophysiology of neuropathic pain is not completely understood. Rats with chronic constriction injury (CCI) develop mechanical allodynia, thermal hypersensitivity, and reduced motor performance (Rota-Rod test) compared with sham-injured mice-similar to mice with spared nerve injury (SNI). The BSCB becomes permeable for small and large tracers 1 day after nerve ligation...
July 28, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28749398/f-wave-index-a-diagnostic-tool-for-peripheral-neuropathy
#9
G R Sathya, N Krishnamurthy, Susheela Veliath, Jayanthi Arulneyam, J Venkatachalam
BACKGROUND & OBJECTIVES: Each skeletal muscle is usually supplied by two or more nerve roots and if one nerve root is affected and the other is spared, the clinically used F wave minimum latency can still be normal. An F wave index was constructed taking into consideration the other parameters of the F wave such as persistence, chronodispersion, latency, arm-length to determine its usefulness in the diagnosis of peripheral neuropathy. This study was undertaken to construct the F wave index in the upper limb for the median nerve in normal healthy adult males and in patients with peripheral neuropathy and to compare the values obtained in both groups...
March 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28746238/-sural-nerve-splitting-in-reverse-sural-artery-perforator-flap-anatomical-study-in-40-cadaver-legs
#10
Hyeonwoo Kim, Julong Hu, Hak Chang, Byung Jun Kim
BACKGROUND: The reverse sural artery perforator flap (RSAPF) has been widely used in reconstructions of the lower extremity. However, along with the high rate of flap necrosis, sural nerve (SN) injury is one of the most frequent complications. This cadaveric study investigated a simple SN preservation technique during RSAPF. METHODS: Anatomic dissection of the sural nerve was performed on 40 lower legs, from 20 cadavers, to investigate the pattern of SN distribution...
July 12, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28744199/differential-impact-of-mir-21-on-pain-and-associated-affective-and-cognitive-behavior-after-spared-nerve-injury-in-b7-h1-ko-mouse
#11
Franziska Karl, Anne Grießhammer, Nurcan Üçeyler, Claudia Sommer
MicroRNAs (miRNAs) are increasingly recognized as regulators of immune and neuronal gene expression and are potential master switches in neuropathic pain pathophysiology. miR-21 is a promising candidate that may link the immune and the pain system. To investigate the pathophysiological role of miR-21 in neuropathic pain, we assessed mice deficient of B7 homolog 1 (B7-H1), a major inhibitor of inflammatory responses. In previous studies, an upregulation of miR-21 had been shown in mouse lymphocytes. Young (8 weeks), middle-aged (6 months), and old (12 months) B7-H1 ko mice and wildtype littermates (WT) received a spared nerve injury (SNI)...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28732667/contribution-of-bdnf-trkb-signalling-in-the-racc-to-the-development-of-pain-related-aversion-via-activation-of-erk-in-rats-with-spared-nerve-injury
#12
Xu Wang, Le Zhang, Yufeng Zhan, Dengping Li, Yuangui Zhang, Gongming Wang, Mengyuan Zhang
The rostral anterior cingulate cortex (rACC) is a key structure in mediating the negative affective component of chronic pain. Brain-derived neurotrophic factor (BDNF) is known to play a critical role in activity-dependent synaptic plasticity, learning and memory. It has been shown that BDNF signalling in the rACC might be involved in spontaneous pain-related aversion, but its underlying mechanism is still largely unknown. To address this question, we measured the mRNA and protein levels of BDNF in the rACC after nerve injury and found that BDNF expression was markedly higher in nerve-injured rats than in controls...
July 18, 2017: Brain Research
https://www.readbyqxmd.com/read/28732186/assessing-the-impact-of-surgeon-experience-on-urinary-continence-recovery-after-robot-assisted-radical-prostatectomy-results-of-four-high-volume-surgeons
#13
Nicola Fossati, Ettore Di Trapani, Giorgio Gandaglia, Paolo Dell'Oglio, Paolo Umari, Nicolò Maria Buffi, Giorgio Guazzoni, Alexander Mottrie, Franco Gaboardi, Francesco Montorsi, Alberto Briganti, Nazareno Suardi
PURPOSE: To test the impact of surgeon experience on urinary continence (UC) recovery after robot-assisted radical prostatectomy (RARP). MATERIALS AND METHODS: The study included 1477 consecutive patients treated with RARP by four surgeons between 2006 and 2014. UC recovery was defined as being completely dry over a 24-hour period at follow-up. Surgeon experience was coded as the total number of RARP performed by the surgeon before the patient's operation. Multivariable analysis tested the association between surgeon experience and UC recovery...
July 21, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28727712/intervertebral-foramen-injection-of-ozone-relieves-mechanical-allodynia-and-enhances-analgesic-effect-of-gabapentin-in-animal-model-of-neuropathic-pain
#14
Wen-Jun Luo, Fan Yang, Fei Yang, Wei Sun, Wei Zheng, Xiao-Liang Wang, Fang-Fang Wu, Jiang-Lin Wang, Jia-Shuang Wang, Su-Min Guan, Jun Chen
BACKGROUND: In a 5-year follow-up study in a hospital in southern China, it was shown that intervertebral foramen (IVF) injection of ozone at the involved segmental levels could significantly alleviate paroxysmal spontaneous pain and mechanical allodynia in patients with chronic, intractable postherpetic neuralgia (PHN) and improve the quality of life. However, so far no proof-of-concept studies in animals have been available. OBJECTIVE: This study was designed to investigate whether IVF ozone has an analgesic effect on animal models of neuropathic and inflammatory pain...
July 2017: Pain Physician
https://www.readbyqxmd.com/read/28727374/dipyridamole-reduces-penile-apoptosis-in-a-rat-model-of-post-prostatectomy-erectile-dysfunction
#15
Omer Kutlu, Ersagun Karaguzel, Ali Ertan Okatan, Ahmet Mentese, Esin Yulug, Ilke Onur Kazaz, Selcuk Kutlu, Eyup Dil, Huseyin Eren, Ahmet Alver
PURPOSE: Despite the nerve-sparing technique, many patients suffer from erectile dysfunction after radical prostatectomy (RP) due to cavernous nerve injury. The aim of this study was to evaluate dipyridamole as a potential treatment agent of post-radical prostatectomy erectile dysfunction. MATERIAL AND METHODS: A total of 18 male Sprague-Dawley rats were randomized into three experimental Groups (SHAM+DMSO, BCNI+DMSO and BCNI+DIP). An animal model of bilateral cavernous nerve crush injury (BCNI) was established to mimic the partial nerve damage during nerve-sparing RP...
June 14, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28727367/prospective-evaluation-of-vesicourethral-anastomosis-outcomes-in-robotic-radical-prostatectomy-during-early-experience-in-a-university-hospital
#16
Lucas Medeiros Burttet, Gabrielle Aguiar Varaschin, Andre Kives Berger, Leandro Totti Cavazzola, Milton Berger, Brasil Silva
PURPOSE: Robotic assisted radical prostatectomy (RARP) presents challenges for the surgeon, especially during the initial learning curve. We aimed to evaluate early and mid-term functional outcomes and complications related to vesicourethral anastomosis (VUA), in patients who underwent RARP, during the initial experience in an academic hospital. We also assessed possible predictors of postoperative incontinence and compared these results with the literature. MATERIALS AND METHODS: We prospectively collected data from consecutive patients that underwent RARP...
June 14, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28725122/two-incisions-direct-anterior-approach-for-thr-surgical-technique-and-early-outcome
#17
Ritesh Rathi, Idriss Tourabaly, Alexis Nogier
PURPOSE: In recent times the direct anterior approach for total hip replacement has gained considerable interest among orthopaedic surgeons because of the relative muscle-sparing nature than other surgical approaches. However, critics believe that this approach is associated with steep learning curve and high complication rates, mainly attributed to a more limited exposure to the femur. In order to make femoral access easier and implantation of acetabulum in anatomic plane, we designed a "two incisions anterior approach technique" for total hip replacement...
September 2017: Journal of Orthopaedics
https://www.readbyqxmd.com/read/28721444/neovascular-glaucoma-after-proton-beam-therapy-of-choroidal-melanoma-incidence-and-risk-factors
#18
Aline I Riechardt, Daniel Pilger, Dino Cordini, Ira Seibel, Enken Gundlach, Annette Hager, Antonia M Joussen
PURPOSE: To analyze the risk factors for the development of neovascular glaucoma (NVG) of patients with choroidal melanoma after proton beam therapy (PBT). METHOD: Clinical case series, retrospective study. We evaluated 629 consecutive patients receiving proton beam therapy for the treatment of a choroidal melanoma at the oncology service at Charité, Berlin and Helmholtz-Zentrum, Berlin between 05/1998 and 11/2008 regarding the development and risk factors of NVG...
July 18, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28721307/multispectral-fluorescence-guided-surgery-a-feasibility-study-in-a-phantom-using-a-clinical-grade-laparoscopic-camera-system
#19
Danny M van Willigen, Nynke S van den Berg, Tessa Buckle, Gijs H KleinJan, James C Hardwick, Henk G van der Poel, Fijs Wb van Leeuwen
Although the possibilities in image guided surgery are advancing rapidly, complex surgical procedures such as nerve sparing prostatectomy still lack precision regarding differentiation between diseased and delicate anatomical structures. Here, the use of complementary fluorescent tracers in combination with a dedicated multispectral fluorescence camera system could support differentiation between healthy and diseased tissue. In this study, we provide proof of concept data indicating how a modified clinical-grade fluorescence laparoscope can be used to sensitively detect white light and three fluorescent dyes (fluorescein, Cy5, and ICG) in a sequential fashion...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28716559/optic-nerve-regeneration-in-mammals-regenerated-or-spared-axons
#20
REVIEW
Dietmar Fischer, Alan R Harvey, Vincent Pernet, Vance P Lemmon, Kevin K Park
Intraorbital optic nerve crush in rodents is widely used as a model to study axon regeneration in the adult mammalian central nervous system. Recent studies using appropriate genetic manipulations have revealed remarkable abilities of mature retinal ganglion cell (RGC) axons to regenerate after optic nerve injury, with some studies demonstrating that axons can then go on to re-innervate a number of central visual targets with partial functional restoration. However, one confounding factor inherent to optic nerve crush injury is the potential incompleteness of the initial lesion, leaving spared axons that later on could erroneously be interpreted as regenerating distal to the injury site...
July 14, 2017: Experimental Neurology
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