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https://www.readbyqxmd.com/read/28446678/differential-involvement-during-latent-hsv-1-infection-of-the-superior-and-inferior-divisions-of-the-vestibular-ganglia-implications-for-vestibular-neuritis
#1
Susanne Himmelein, Anja Lindemann, Inga Sinicina, Anja K E Horn, Thomas Brandt, Michael Strupp, Katharina Hüfner
Controversy still surrounds both the etiology and pathophysiology of vestibular neuritis (VN). Especially uncertain is why the superior vestibular nerve (SVN) is more frequently affected than the inferior part (IVN), which is partially or totally spared. To address this question we developed an improved method for preparing human vestibular ganglia (VG) and nerve. Subsequently macro- and micro-anatomical as well as PCR studies were performed on 38 human ganglia from 38 individuals. The SVN was 2.4 mm longer than the IVN, and in 65% of the cases the IVN ran in two separate bony canals, which was not the case for the SVN...
April 26, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28445714/the-toll-like-receptor-2-agonist-pam3csk4-is-neuroprotective-after-spinal-cord-injury
#2
Nicole S Stivers, Nicolas Pelisch, Ben C Orem, Joshua Williams, Jacqueline M Nally, David P Stirling
Microglia/macrophage activation and recruitment following spinal cord injury (SCI) is associated with both detrimental and reparative functions. Stimulation of the innate immune receptor Toll-like receptor-2 (TLR2) has shown to be beneficial following SCI, and it increases axonal regeneration following optic nerve crush. However, the mechanism(s) remain unclear. As microglia express high levels of TLR2, we hypothesized that modulating the microglial response to injury using a specific TLR2 agonist, Pam3CSK4, would prevent secondary-mediated white matter degeneration following SCI...
April 23, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28432399/-when-is-surgical-resection-of-metastases-in-testicular-germ-cell-tumors-indicated-and-is-there-a-scientific-basis
#3
A Heidenreich, P Paffenholz, F Haidl, D Pfister
Surgical resection of metastases represents an integral part of curative management in patients with testicular germ cell tumors (GCT). Primary nerve-sparing retroperitoneal lymph node dissection (nsRPLND) for low volume metastases in clinical stages I-IIB has to be differentiated from the more complex and more extensive postchemotherapeutic procedures. In Europe, primary nerve-sparing retroperitoneal lymph node dissection (nsRPLND) for clinical stage I nonseminomatous GCT (NSGCT) plays a subordinate. In clinical stage IIA/B, nsRPLND is indicated for patients with marker-negative metastases in whom cure rates of about 65% can be achieved with surgery alone...
April 21, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28420964/identification-of-the-spinal-expression-profile-of-non-coding-rnas-involved-in-neuropathic-pain-following-spared-nerve-injury-by-sequence-analysis
#4
Jun Zhou, Qingming Xiong, Hongtao Chen, Chengxiang Yang, Youling Fan
Neuropathic pain (NP) is caused by damage to the nervous system, resulting in aberrant pain, which is associated with gene expression changes in the sensory pathway. However, the molecular mechanisms are not fully understood. A non-coding Ribose Nucleic Acid (ncRNA) is an RNA molecule that is not translated into a protein. NcRNAs are involved in many cellular processes, and mutations or imbalances of the repertoire within the body can cause a variety of diseases. Although ncRNAs have recently been shown to play a role in NP pathogenesis, the specific effects of ncRNAs in NP remain largely unknown...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28409885/long-term-results-of-the-transmanubrial-osteomuscular-sparing-approach-for-pediatric-tumors
#5
Aziz El Madi, Sabine Irtan, Frédérique Sauvat, Michel Zérah, Gudrun Schleiermacher, Louise Galmiche-Roland, Véronique Minard-Colin, Hervé Brisse, Sabine Sarnacki
BACKGROUND: The complete and safe resection of pediatric cervicothoracic tumors, mostly represented by neurogenic tumors, remains a surgical challenge because of the complex anatomy of this region. The transmanubrial osteomuscular-sparing approach (TOSA) is an alternative to isolated or combined cervical and thoracic approaches enabling the control of supra-aortic vessels and nerves through the thoracic inlet. METHODS: We retrospectively reviewed the tumor characteristics, completeness of resection, morbidity, and long-term outcome of patients with cervicothoracic tumors removed by TOSA between 2000 and 2012 in our institution...
April 14, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28406779/classic-raymond-syndrome
#6
Majid Khan, Sadaf Naveed, Iqbal Haider, Mohammad Humayun, Abidullah Khan
Classic Raymond syndrome presents with abducens nerve palsy on the ipsilateral side with contralateral hemiparesis and facial nerve paralysis. A 60-year gentleman presented with deviation of left angle of mouth and right sided weakness. Examination showed that he had left sided abducens nerve palsy, with contralateral central facial paralysis and paresis. MRI of brain confirmed left pontine infarct. These findings were consistent with classic Raymond syndrome. Till now, only a few cases have been reported worldwide, this being the first case reported in South Asia...
March 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28398295/reply-to-non-surgically-related-causes-of-erectile-dysfunction-after-bilateral-nerve-sparing-radical-prostatectomy
#7
M G Culha, O O Cakir
No abstract text is available yet for this article.
April 11, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28395083/pathological-confirmation-of-optic-neuropathy-in-familial-dysautonomia
#8
Carlos E Mendoza-Santiesteban, Jose-Alberto Palma, Thomas R Hedges, Nora V Laver, Nada Farhat, Lucy Norcliffe-Kaufmann, Horacio Kaufmann
Clinical data suggest that optic neuropathy and retinal ganglion cell loss are the main cause of visual decline in patients with familial dysautonomia, but this has not previously been confirmed by pathological analyses. We studied retinas and optic nerves in 6 eyes from 3 affected patients obtained at autopsy. Analyses included routine neurohistology and immunohistochemistry for neurofilaments, cytochrome c oxidase (COX), and melanopsin-containing ganglion cells. We observed profound axon loss in the temporal portions of optic nerves with relative preservation in the nasal portions; this correlated with clinical and optical coherence tomography findings in 1 patient...
March 1, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/28394696/pharmacology-pharmacokinetics-and-metabolism-of-the-dna-decoy-ayx1-for-the-prevention-of-acute-and-chronic-post-surgical-pain
#9
Julien Mamet, Scott Harris, Michael Klukinov, David C Yeomans, Renee R Donahue, Brad K Taylor, Kelly Eddinger, Tony Yaksh, Donald C Manning
Background AYX1 is an unmodified DNA-decoy designed to reduce acute post-surgical pain and its chronification with a single intrathecal dose at the time of surgery. AYX1 inhibits the transcription factor early growth response protein 1, which is transiently induced at the time of injury and triggers gene regulation in the dorsal root ganglia and spinal cord that leads to long-term sensitization and pain. This work characterizes the AYX1 dose-response profile in rats and the link to AYX1 pharmacokinetics and metabolism in the cerebrospinal fluid, dorsal root ganglia, and spinal cord...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28394523/-comparison-of-functional-outcomes-after-retropubic-and-robot-assisted-radical-nerve-sparing-prostatectomy-conducted-by-surgeons-with-total-caseloads-of-over-1000-prostatectomies
#10
D Yu Pushkar, V V Dyakov, A O Vasilyev, D V Kotenko
AIM: To compare the functional outcomes of bilateral nerve-sparing robot-assisted radical prostatectomy (RARP) and radical retropubic prostatectomy (RRP) at 12 months after surgery. MATERIALS AND METHODS: This is a retrospective study of two groups, each of 50 sexually active patients with localized low risk prostate cancer. The first group comprised patients who underwent RRP, while the second underwent RARP. All operations were carried out sequentially from January to August 2015 using nerve-sparing technique...
April 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28394522/-the-role-of-waterjet-dissection-in-improving-erectile-function-and-continence-after-nerve-sparing-prostatectomy
#11
P V Glybochko, Yu G Alyaev, L M Rapoport, N A Grigorev, E A Bezrukov, D G Tsarichenko, E S Sirota, G A Martirosyan
INTRODUCTION: Erectile dysfunction (ED) and urinary incontinence (UI) following radical prostatectomy (RP) adversely impact patients psycho-emotional status reducing the quality of life and treatment satisfaction. AIM: To investigate the rates of regaining continence and erectile function (EF) after nerve-sparing radical retropubic prostatectomy (NS-RRP) and nerve-sparing laparoscopic radical prostatectomy (NS-LRP) in the early postoperative period. MATERIALS AND METHODS: The study comprised 116 patients who preserved sexual activity and the ability to have sex...
April 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28393429/lack-of-analgesic-synergy-of-the-cholecystokinin-receptor-antagonist-proglumide-and-spinal-cord-stimulation-for-the-treatment-of-neuropathic-pain-in-rats
#12
Shinsuke Inoue, Lisa M Johanek, Kathleen A Sluka
OBJECTIVE: Neuropathic pain is difficult to manage and treat. Spinal cord stimulation (SCS) has become an established procedure for treating chronic neuropathic pain that is refractory to pharmacological therapy. In order to achieve better analgesia, a number of studies have evaluated the effectiveness of combining drug therapy with SCS. Cholecystokinin antagonists, such as proglumide, enhance the analgesic efficacy of endogenous opioids in animal models of pain. We previously reported that both systemic and spinal administration of proglumide enhances analgesia produced by both low- and high-frequency transcutaneous electrical nerve stimulation (TENS)...
April 10, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28392434/-update-on-laparoscopic-electrosurgical-devices-and-their-use-in-complex-urologic-procedures
#13
G Boukheir, F Aoun, S Albisinni, T Roumeguère
INTRODUCTION: Laparoscopy is the standard of care for many urologic procedures and witnesses nowadays technological advancements. Hemostasis is highly important in laparoscopy since bleeding could rapidly alter the operative conditions. The objective of this review is to expose the different electrosurgical techniques, their history and their applications in urology. MATERIAL AND METHODS: A literature review was overdone using the following terms "laparoscopic electrosurgery" and/or "nephrectomy" and/or "prostatectomy"...
April 6, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/28392432/-surgical-approach-and-sexual-outcomes-after-radical-prostatectomy
#14
K Caillet, A Lipsker, E Alezra, P De Sousa, G Pignot
BACKGROUND: Radical prostatectomy is curative surgical treatment of choice for localized prostate cancer. The objectives are cancer control, preservation of continence and preservation of sexuality, the combination of the three constituting the Trifecta. OBJECTIVE: The objective of this study was to assess, through the analysis of the literature, the sexual outcomes according to surgical approach: radical prostatectomy by laparotomy (PRL), laparoscopic radical prostatectomy (PRLa) and laparoscopic robot-assisted radical prostatectomy (PRLaRA), when nerve sparing was practiced...
April 6, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/28392393/functional-outcomes-following-nerve-sparing-prostatectomy-augmented-with-seminal-vesicle-sparing-compared-to-standard-nerve-sparing-prostatectomy-results-from-a-randomized-controlled-trial
#15
Scott M Gilbert, Rodney L Dunn, David C Miller, Jeffrey S Montgomery, Ted A Skolarus, Alon Z Weizer, David P Wood, Brent K Hollenbeck
INTRODUCTION: Seminal vesicle sparing may reduce the risk of neurovascular bundle injury and improve functional outcomes after prostatectomy. While several observational studies have reported better functional outcomes following seminal vesicle sparing approaches, evidence from randomized trials is lacking. We conducted a randomized controlled trial comparing functional and cancer control outcomes between nerve-sparing prostatectomy augmented with seminal vesicle sparing (NSP+SVS) and standard nerve-sparing prostatectomy (NSP)...
April 6, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28385075/propensity-score-matched-comparison-of-partial-to-whole-gland-cryotherapy-for-intermediate-risk-prostate-cancer-an-analysis-of-the-cold-registry-data
#16
Kae Jack Tay, Thomas J Polascik, Ahmed El-Shafei, Efrat Tsivian, J Stephen Jones
OBJECTIVE: To compare the oncological and functional outcomes of partial versus whole-gland cryotherapy for men with intermediate-risk prostate cancer. SUBJECTS/PATIENTS: Men with intermediate-risk prostate cancer treated with primary prostate cryotherapy from 1993-2013 were selected from the Cryo On-Line Data Registry for a 1:1 matched comparison between those undergoing whole-gland and partial prostate cryotherapy (targeted-ablation, unilateral/bilateral nerve-sparing ablations)...
April 6, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28382129/labyrinthectomy-and-vestibular-neurectomy-for-intractable-vertiginous-symptoms
#17
Alfredo Vega Alarcón, Lourdes Olivia Vales Hidalgo, Rodrigo Jácome Arévalo, Marite Palma Diaz
Introduction Labyrinthectomy and vestibular neurectomy are considered the surgical procedures with the highest possibility of controlling medically untreatable incapacitating vertigo. Ironically, after 100 years of the introduction of both transmastoid labyrinthectomy and vestibular neurectomy, the choice of which procedure to use rests primarily on the evaluation of the hearing and of the surgical morbidity. Objective To review surgical labyrinthectomy and vestibular neurectomy for the treatment of incapacitating vestibular disorders...
April 2017: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/28372960/the-kiel-concept-of-long-term-administration-of-daily-low-dose-sildenafil-initiated-in-the-immediate-post-prostatectomy-period-evaluation-and-comparison-with-the-international-literature-on-penile-rehabilitation
#18
REVIEW
Daniar K Osmonov, Klaus P Jünemann, Andreas Bannowsky
INTRODUCTION: Radical prostatectomy (RP) is the most common definitive invasive treatment option for localized prostate cancer. Although the different surgical procedures-open RP, laparoscopic RP, and robot-assisted laparoscopic RP-do not differ significantly for the results of postoperative erectile dysfunction (ED) and continence, the fear of losing erectile function (EF) is often an important factor for preoperatively sexually active men when deciding for or against a procedure. AIM: To review the available literature on rehabilitation of EF after RP and to evaluate the value of the "Kiel concept" against different strategies of phosphodiesterase type 5 inhibitor (PDE5i) low-dose treatments...
March 31, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28371010/laparoscopic-ventral-rectopexy-for-rectal-prolapse-and-rectal-intussusception-using-a-biological-mesh
#19
Sinan Albayati, Matthew J Morgan, Catherine E Turner
AIM: Laparoscopic ventral rectopexy (LVR) is a nerve sparing technique for the treatment of rectal prolapse. Concerns about the use of synthetic meshes in the pelvis and the associated risk of erosion have led to the recent use of biological meshes in some colorectal units. This retrospective study aims to assess the outcomes of patients undergoing LVR using a non-cross-linked non-dermal biological mesh. METHODS: Medical notes of all patients who underwent LVR between December 2011 and May 2014 were reviewed...
March 29, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28370267/external-validation-of-a-nomogram-for-identification-of-pathologically-favorable-disease-in-intermediate-risk-prostate-cancer-patients
#20
Jean-Baptiste Beauval, Bastien Cabarrou, Giorgio Gandaglia, Pierre-Marie Patard, Adil Ouzzane, Alexandre de la Taille, Michel Soulié, Alberto Briganti, Guillaume Ploussard, François Rozet, Mathieu Roumiguié
OBJECTIVE: To establish an external validation of the new nomogram from Gandaglia et al which provides estimates of the probability of pathological favorable disease in pre-operatively defined intermediate-risk PCa. PATIENTS AND METHODS: Overall, 2928 intermediate-risk PCa patients according to the D'Amico classification undergoing RP and bilateral lymph node dissection in seven academic centres between 2000 and 2011. Pathologically favorable PCa was defined as low-grade organ-confined disease...
April 2, 2017: Prostate
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