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nerve sparing

Bin Du, You-Quan Ding, Xia Xiao, Hong-Yi Ren, Bing-Yin Su, Jian-Guo Qi
BACKGROUND: Antigen-specific and MHCII-restricted CD4+ αβ T cells have been shown or suggested to play an important role in the transition from acute to chronic mechanical allodynia after peripheral nerve injuries. However, it is still largely unknown where these T cells infiltrate along the somatosensory pathways transmitting mechanical allodynia to initiate the development of chronic mechanical allodynia after nerve injuries. Therefore, the purpose of this study was to ascertain the definite neuroimmune interface for these T cells to initiate the development of chronic mechanical allodynia after peripheral nerve injuries...
March 15, 2018: Journal of Neuroinflammation
Tanya Moutray, Jennifer R Evans, Noemi Lois, David J Armstrong, Tunde Peto, Augusto Azuara-Blanco
BACKGROUND: Diabetic retinopathy (DR) is a chronic progressive disease of the retinal microvasculature associated with prolonged hyperglycaemia. Proliferative DR (PDR) is a sight-threatening complication of DR and is characterised by the development of abnormal new vessels in the retina, optic nerve head or anterior segment of the eye. Argon laser photocoagulation has been the gold standard for the treatment of PDR for many years, using regimens evaluated by the Early Treatment of Diabetic Retinopathy Study (ETDRS)...
March 15, 2018: Cochrane Database of Systematic Reviews
David Reichstein, Kayla Karan
PURPOSE OF REVIEW: Plaque brachytherapy remains the dominant globe-sparing therapy of uveal melanoma. This report highlights recent advances, which have expanded plaque brachytherapy's uses as well as improved the surgical technique. RECENT FINDINGS: Plaque brachytherapy is effective for tumors that may previously have demanded enucleation. Plaque brachytherapy can be used to control large melanomas as well as melanomas touching the optic nerve. Improvements in planning and design have made plaque therapy simpler for the surgical operator and may reduce collateral radiation damage to normal ocular structures...
March 13, 2018: Current Opinion in Ophthalmology
Antonino Ditto, Giorgio Bogani, Umberto Leone Roberti Maggiore, Fabio Martinelli, Valentina Chiappa, Carlos Lopez, Stefania Perotto, Domenica Lorusso, Francesco Raspagliesi
OBJECTIVE: Nerve-sparing radical hysterectomy (NSRH) was introduced with the aim to reduce pelvic dysfunctions related to conventional radical hysterectomy (RH). Here, we sought to assess the effectiveness and safety of NSRH in a relatively large number of the patients of cervical cancer (CC) patients undergoing either primary surgery or neoadjuvant chemotherapy (NACT) followed by surgery. METHODS: Outcomes of consecutive patients undergoing NSRH and of a historical cohort of patients undergoing conventional RH were retrospectively reviewed...
February 28, 2018: Journal of Gynecologic Oncology
Samuel K Cho, Jun S Kim, Samuel C Overley, Robert K Merrill
Cervical laminoplasty was initially described for the management of cervical myelopathy resulting from multilevel stenosis secondary to ossification of the posterior longitudinal ligament. The general concepts are preservation of the dorsal elements, preservation of segmental motion, and expansion of the spinal canal via laminar manipulation. No clear evidence suggests that laminoplasty is superior to either posterior laminectomy or anterior cervical diskectomy and fusion. However, laminoplasty has its own advantages, indications, and complications...
March 7, 2018: Journal of the American Academy of Orthopaedic Surgeons
Linda M Huynh, Kathryn Osann, Douglas Skarecky, Thomas E Ahlering
OBJECTIVE: To introduce a patient-reported erection fullness scale (% fullness) following robot-assisted radical prostatectomy as a qualitative adjunct to the IIEF-5 and as a 90-day predictor of two-year potency outcomes. PATIENTS AND METHODS: Prospective data was collected from 540 men with preoperative IIEF-5 22-25 who underwent RARP by a single surgeon, of which 299 had complete data at all time points up to 2 years. In addition to standard assessment tools (IIEF-5 and erections sufficient for intercourse), patients were asked to "indicate the fullness you are able to achieve in erections compared to before surgery?" (0-10…100%)...
March 9, 2018: BJU International
Tobias Gross, Marc Furrer, Petra Schorno, Patrick Y Wuethrich, Marc P Schneider, George N Thalmann, Fiona C Burkhard
OBJECTIVES: To compare functional and oncological outcomes of reproductive organ sparing cystectomy (ROSC) compared to standard cystectomy (SC) in females undergoing orthotopic ileal bladder substitution (OBS). PATIENTS AND METHODS: From 1995 to 2016, 121 consecutive females undergoing OBS were prospectively included in this single center non-randomized clinical follow up study including a ROSC and SC group. Urinary continence, the need for intermittent self-catheterization (ISC), lateral standing micturition cystourethrogram (MCUG), urethral pressure profiles findings, if available, and oncological outcomes were assessed and compared for ROSC or SC...
March 9, 2018: BJU International
Hiromi Yamamoto, Toru Kawada, Shuji Shimizu, Kazunori Uemura, Masashi Inagaki, Kazuyoshi Kakehi, Yoshitaka Iwanaga, Kanji Fukuda, Tadayoshi Miyamoto, Shunichi Miyazaki, Masaru Sugimachi
AIMS: To assess the acute effects of intravenous ivabradine, a selective bradycardic agent, on carotid sinus baroreflex-mediated sympathetic arterial pressure (AP) and heart rate (HR) responses. METHODS AND RESULTS: In anesthetized and vagotomized Wistar-Kyoto rats (n=6), carotid sinus baroreceptor regions were isolated. Changes in splanchnic sympathetic nerve activity (SNA), AP, and HR in response to a step-wise pressure input were examined before and after intravenous ivabradine (2mg/kg)...
April 15, 2018: International Journal of Cardiology
Ruggero Ruggieri, Stefania Naccarato, Rosario Mazzola, Francesco Ricchetti, Stefanie Corradini, Alba Fiorentino, Filippo Alongi
BACKGROUND: Linac-based stereotactic radiosurgery or fractionated stereotactic radiotherapy (SRS/FSRT) of multiple brain lesions using volumetric modulated arc therapy (VMAT) is typically performed by a multiple-isocenter approach, i.e. one isocenter per lesion, which is time-demanding for the need of independent setup verifications of each isocenter. Here, we present our initial experience with a new dedicated mono-isocenter technique with multiple non-coplanar arcs (HyperArc™, Varian Inc...
March 5, 2018: Radiation Oncology
Ida Marabese, Serena Boccella, Monica Iannotta, Livio Luongo, Vito de Novellis, Francesca Guida, Nicola Serra, Antonio Farina, Sabatino Maione, Enza Palazzo
The study investigated the role of the metabotropic glutamate receptor subtype 7 (mGluR7) in pain signalling in the dorsal striatum of sham and neuropathic rats. Supraspinal circuitries involved in the dorsal striatum control of pain were also explored. In the sham rats, microinjection of N,N'-bis(diphenylmethyl)-1,2-ethanediamine (AMN082), a selective mGluR7 positive allosteric modulator, into the dorsal striatum, facilitated pain, increased the activity of the ON cells and inhibited the activity of the OFF cells in the rostral ventromedial medulla, and decreased glutamate levels in the dorsal striatum...
March 2, 2018: Neuropharmacology
Lubin Chen, Jianying Huang, Peng Zhao, Anna-Karin Persson, Fadia B Dib-Hajj, Xiaoyang Cheng, Andrew Tan, Stephen G Waxman, Sulayman D Dib-Hajj
Voltage-gated sodium channels NaV 1.7, NaV 1.8 and NaV 1.9 have been the focus for pain studies because their mutations are associated with human pain disorders, but the role of NaV 1.6 in pain is less understood. In this study, we selectively knocked out NaV 1.6 in dorsal root ganglion (DRG) neurons, using NaV 1.8-Cre directed or adeno-associated virus (AAV)-Cre mediated approaches, and examined the specific contribution of NaV 1.6 to the tetrodotoxin-sensitive (TTX-S) current in these neurons and its role in neuropathic pain...
March 1, 2018: Scientific Reports
Corina Christmann-Schmid, Isabell Koerting, Esther Ruess, Ivo Faehnle, Jörg Krebs
To date sacrocolpopexy is regarded as the gold standard treatment for primarily apical compartment prolapse and multi-compartment prolapse. Most bladder and bowel dysfunction improves post-operatively after sacrocolpopexy, however de-novo bowel or de-novo bladder dysfunction can occur. The inferior hypogastric nerve is commonly known amongst pelvic surgeons. However the inferior hypogastric nerve and its fine fibers are difficult to identify, iatrogenic lesion is commonly tolerated although this can lead to bladder, bowel and sexual dysfunction...
March 1, 2018: Acta Obstetricia et Gynecologica Scandinavica
Duygu Gulmez Sevim, Metin Unlu, Serap Sonmez, Murat Gultekin, Cagatay Karaca, Ayse Ozturk Oner
PURPOSE: To define the alterations in retinal vessel diameter in Parkinson's disease (PD) by optical coherence tomography (OCT). METHODS: This is a case-control study including 41 eyes of 41 patients with diagnosis of PD and 35 eyes of 35 age- and sex-matched control subjects. All subjects underwent complete neurological and ophthalmological examinations before measurements. Retinal vessel diameters and peripapillary retinal nerve fiber layer (pRNFL) thicknesses were evaluated with spectral domain OCT (SD-OCT) with a circular scan centered at the optic disc...
February 28, 2018: International Ophthalmology
Maria Domenica Sanna, Nicoletta Galeotti
Histone deacetylase inhibitors (HDACIs) interfere with the epigenetic process of histone acetylation and are known to have analgesic properties in models of chronic inflammatory pain. Administration of a selective HDAC1 inhibitor (LG325) in SNI-subjected mice significantly attenuated behavior related to injury-induced pain. Understanding the HDAC1 pathway in epigenetic regulation of pathological pain is of great medical relevance. Spared nerve injury (SNI) mice showed a significant increase in the HDAC1 protein levels within spinal cord in coincidence with the nociceptive phenotype at 1 and 3 weeks after nerve injury...
February 27, 2018: European Journal of Pharmacology
Giuseppe Vizzielli, Carmine Conte, Massimo Romano, Anna Fagotti, Barbara Costantini, Claudio Lodoli, Salvatore Gueli Alletti, Khaled Gaballah, Fabio Pacelli, Alfredo Ercoli, Giovanni Scambia, Valerio Gallotta
AIM: To evaluate the clinical impact of the use of the Caiman® articulating energy device in advanced ovarian cancer (AOC) including rectosigmoid resection [e.g. modified posterior exenteration (MPE)]. PATIENTS AND METHODS: This was a prospective single-institution observational study with women undergoing MPE where all soft-tissue dissections and vessel ligations were performed using the Caiman® device. Intraoperative and postoperative surgical data were collected...
March 2018: In Vivo
Anil Kumar, Harshpreet Kaur, Arti Singh
Neuropathic Pain (NP) is a painful condition which is a direct consequence of a lesion or disease affecting the somatosensory system with symptoms like allodynia, hyperalgesia. It has complex pathogenesis as it involves several molecular signaling pathways, thus numerous reliable animal models are crucial to understand the underlying mechanism of NP and formulate effective management therapy. Some models like spinal cord injury, chronic constriction injury, spinal nerve ligation, chemotherapy induced peripheral neuropathy, diabetes-induced NP and many more are discussed...
October 2, 2017: Pharmacological Reports: PR
Wen Chen, Ye-Nan Chi, Xue-Jing Kang, Qing-Ying Liu, Hao-Lin Zhang, Zhi-Hua Li, Zi-Fang Zhao, Yin Yang, Li Su, Jie Cai, Fei-Fei Liao, Ming Yi, You Wan, Feng-Yu Liu
Injuries to peripheral nerve fibers induce neuropathic pain. But the involvement of adjacent uninjured fibers to pain is not fully understood. The present study aims to investigate the possible contribution of Cav 3.2 T-type calcium channels in uninjured afferent nerve fibers to neuropathic pain in rats with spared nerve injury (SNI). Aβ-, Aδ- and C-fibers of the uninjured sural nerve were sensitized revealed by in vivo single-unit recording, which were accompanied by accumulation of Cav 3.2 T-type calcium channel proteins shown by Western blotting...
2018: Frontiers in Molecular Neuroscience
Megan K Mills, Bryn Putbrese, Hailey Allen, Sarah E Stilwill
Lymphangiomatosis is an uncommon disease process characterized by multisystem lymphatic malformations that can involve numerous body systems, including organs, muscles, soft tissues, and bones. Involvement of the nervous system is rare and has even been previously described as a site of sparing. We present a case of a 24-year-old female with known lymphangiomatosis, presenting with acute onset of lower extremity paresthesias, weakness, and new urinary retention. MRI of the pelvis revealed lymphangiomatosis of the sacral plexus, which has not been previously reported...
February 21, 2018: Skeletal Radiology
Donald S Strassberg, Suzanne M Zavodni, Paul Gardner, Christopher Dechet, Robert A Stephenson, Kelsey K Sewell
Objectives: To compare robotic-assisted laparoscopic prostatectomy with conventional retropubic radical prostatectomy in maintaining pre-surgery levels of urinary and sexual functioning and to evaluate the efficacy of nerve sparing in prostatectomies in protecting urinary functioning. Material and Methods: Patients (n = 385) receiving both surgical procedures were surveyed prior to surgery. Multiple measures, including the Expanded Prostate Cancer Index Composite, the Sexual Health Inventory for Men, and the International Prostate Symptom Score, assessed sexual and urinary function at an average of 12 months post-surgery...
November 2017: Current Urology
Rodolfo Montironi, Liang Cheng, Antonio Lopez-Beltran, Marina Scarpelli, Francesco Montorsi
No abstract text is available yet for this article.
February 16, 2018: European Urology
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