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metabonomics & Encephalopathy

Lili Song, Pengwei Zhuang, Mengya Lin, Mingqin Kang, Hongyue Liu, Yuping Zhang, Zhen Yang, Yunlong Chen, Yanjun Zhang
Recently, increasing attention has been paid to diabetic encephalopathy, which is a frequent diabetic complication and affects nearly 30% of diabetics. Because cognitive dysfunction from diabetic encephalopathy might develop into irreversible dementia, early diagnosis and detection of this disease is of great significance for its prevention and treatment. This study is to investigate the early specific metabolites biomarkers in urine prior to the onset of diabetic cognitive dysfunction (DCD) by using metabolomics technology...
August 9, 2017: Journal of Proteome Research
Luisa Baker, Bernard Lanz, Fausto Andreola, Javier Ampuero, Anisha Wijeyesekera, Elaine Holmes, Nicolaas Deutz
Hepatic encephalopathy (HE) is a neuropsychiatric syndrome which frequently accompanies acute or chronic liver disease. It is characterized by a variety of symptoms of different severity such as cognitive deficits and impaired motor functions. Currently, HE is seen as a consequence of a low grade cerebral oedema associated with the formation of cerebral oxidative stress and deranged cerebral oscillatory networks. However, the pathogenesis of HE is still incompletely understood as liver dysfunction triggers exceptionally complex metabolic derangements in the body which need to be investigated by appropriate technologies...
December 2016: Metabolic Brain Disease
Konstantinos John Dabos, John Andrew Parkinson, Ian Howard Sadler, John Nicholas Plevris, Peter Clive Hayes
AIM: To identify plasma metabolites used as biomarkers in order to distinguish cirrhotics from controls and encephalopathics. METHODS: A clinical study involving stable cirrhotic patients with and without overt hepatic encephalopathy was designed. A control group of healthy volunteers was used. Plasma from those patients was analysed using (1)H - nuclear magnetic resonance spectroscopy. We used the Carr Purcell Meiboom Gill sequence to process the sample spectra at ambient probe temperature...
June 28, 2015: World Journal of Hepatology
Paola Scano, Antonella Rosa, Alessandra Incani, Caterina Maestrale, Cinzia Santucciu, Daniela Perra, Sarah Vascellari, Alessandra Pani, Ciriaco Ligios
While neurochemical metabolite modifications, determined by different techniques, have been diffusely reported in human and mice brains affected by transmissible spongiform encephalopathies (TSEs), this aspect has been little studied in the natural animal hosts with the same pathological conditions so far. Herein, we investigated, by high resolution (1)H NMR spectroscopy and multivariate statistical data analysis, the brain metabolite profile of sheep exposed to a scrapie agent in a naturally affected flock...
July 2015: Molecular BioSystems
Beatriz Jiménez, Carmina Montoliu, David A MacIntyre, Miguel A Serra, Abdallah Wassel, María Jover, Manuel Romero-Gomez, Jose M Rodrigo, Antonio Pineda-Lucena, Vicente Felipo
Minimal hepatic encephalopathy (MHE) reduces quality of life of cirrhotic patients, predicts overt hepatic encephalopathy, and is associated with poor prognosis. We hypothesized that MHE arises once metabolic alterations derived from the liver reach a particular threshold. Our aim was to assess whether metabolic profiling of serum samples by high-field (1)H-nuclear magnetic resonance spectroscopy ((1)H NMR) and subsequent multivariate analyses would be useful to characterize metabolic perturbations associated with MHE and to identify potential metabolic biomarkers...
October 1, 2010: Journal of Proteome Research
Horace R T Williams, I Jane Cox, Simon D Taylor-Robinson
No abstract text is available yet for this article.
September 2008: Liver International: Official Journal of the International Association for the Study of the Liver
Ignasi Barba, Nicolas Chatauret, David García-Dorado, Juan Córdoba
BACKGROUND: There are no good biomarkers for grading hepatic encephalopathy (HE) and monitoring the effectiveness of therapeutic measures. METHODS: We applied (1)H nuclear magnetic resonance (NMR)-based metabonomics of brain samples obtained from acute liver failure rats sacrificed after ligation of the hepatic artery (at 6 h, precoma and coma stages), sham-operated controls and mild hypothermia (35 degrees C) for 6 or 15 h as a therapeutic measure. RESULTS: Partial least square discriminant analysis established a classification model that scored the severity of encephalopathy...
September 2008: Liver International: Official Journal of the International Association for the Study of the Liver
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