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"Membranous GN"

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https://www.readbyqxmd.com/read/27545628/-kidney-disease-in-sant-andrea-hospital-a-biopsy-based-epidemiologic-study
#1
Mariachiara Mei, Paolo Menè, Antonella Stoppacciaro
The aim of this retrospective study is to investigate the prevalence and pathological features of kidney inflammatory nephropathies diagnosed in Sant'Andrea Hospital, from January 2003 to April 2015. In this period, 246 kidney biopsies have been diagnosed in our Hospital. Excluding cases of kidney neoplasms and non-diagnostic samples, 195 cases were reviewed. Primary glomerulonephritis (GN) is the most common diagnosis. Among these, Membranous GN represents the majority of cases (20.4%), followed by IgA Nephropathy (12...
July 2016: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/27215253/histopathological-types-in-adult-nephrotic-syndrome
#2
Md Ghulam Yusuf, Bidhu Bhushan Das, Amaresh Chandra Shaha, Md Zakir Hossain
In Bangladesh, there are very few studies about biopsy proven adult Nephrotic syndrome (NS) with histological types and their clinical findings. To determine the histological types of glomerulonephritis (GN) in adult NS and correlate them with the clinical presentations and biochemical parameters, we studied 100 biopsies in 87 patients who underwent ultrasonography- guided renal biopsy in Rangpur Medical College and Hospital from July 2010 to June 2012. The mean age of the patients was 32.8 ± 13.2 years; male was preponderance (72...
May 2016: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/26845212/-membranous-glomerulonephritis-with-crescent-overlapping
#3
Gioacchino Li Cavoli, Rita Passantino, Angelo Ferrantelli, Luisa Bono, Calogera Tortorici, Carlo Giammarresi, Tancredi Vincenzo Li Cavoli, Giacomo Ferrantelli, Ugo Rotolo
Acute crescentic transformation is a rare but well described event in patients with membranous glomerulonephritis. We report our experience with a 66-year-old Caucasian man presented for rapid decline in renal function. For nearly 10 years, he was suffering from hypertension and mixed sensori-motor polyneuropathy. He performed therapy with prednisone and azathioprine, suspended 1 year before presentation. Moreover, six months before presentation, laboratory tests showed a serum creatinine concentration 220 mol/L and a 24-h protein excretion 0,75 g/d...
November 2015: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/26586063/analysis-of-histopathological-pattern-of-kidney-biopsy-specimens-in-kuwait-a-single-center-five-year-prospective-study
#4
Emad Abdallah, Bassam Al-Helal, Reem Asad, Shreeram Kannan, Wael Draz, Zeyad Abdelgawad
Glomerulonephritis (GN) varies in incidence in different geographical areas due to different socioeconomic conditions and ethnicity, genetic variability and environmental factors. Our study is aimed to determine the histopathological pattern of kidney biopsies in Kuwait over the preceding five years. In a prospective study, we analyzed the clinical and pathological data of 214 kidney biopsies that were performed during the period from November 2009 to November 2014 at the Al-Khezam Dialysis Center, Al-Adan Hospital, Kuwait...
November 2015: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/26567243/mayo-clinic-renal-pathology-society-consensus-report-on-pathologic-classification-diagnosis-and-reporting-of-gn
#5
Sanjeev Sethi, Mark Haas, Glen S Markowitz, Vivette D D'Agati, Helmut G Rennke, J Charles Jennette, Ingeborg M Bajema, Charles E Alpers, Anthony Chang, Lynn D Cornell, Fernando G Cosio, Agnes B Fogo, Richard J Glassock, Sundaram Hariharan, Neeraja Kambham, Donna J Lager, Nelson Leung, Michael Mengel, Karl A Nath, Ian S Roberts, Brad H Rovin, Surya V Seshan, Richard J H Smith, Patrick D Walker, Christopher G Winearls, Gerald B Appel, Mariam P Alexander, Daniel C Cattran, Carmen Avila Casado, H Terence Cook, An S De Vriese, Jai Radhakrishnan, Lorraine C Racusen, Pierre Ronco, Fernando C Fervenza
Renal pathologists and nephrologists met on February 20, 2015 to establish an etiology/pathogenesis-based system for classification and diagnosis of GN, with a major aim of standardizing the kidney biopsy report of GN. On the basis of etiology/pathogenesis, GN is classified into the following five pathogenic types, each with specific disease entities: immune-complex GN, pauci-immune GN, antiglomerular basement membrane GN, monoclonal Ig GN, and C3 glomerulopathy. The pathogenesis-based classification forms the basis of the kidney biopsy report...
May 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/26518925/recurrent-glomerulonephritis-in-renal-transplantation-experience-in-our-renal-transplantation-center
#6
L Cañas, D López, J F Pérez, I Bancu, J Juega, A Ariza, J Bonet, R Lauzurica
BACKGROUND: Post-transplant recurrent glomerulonephritis (RGN) is the third cause of graft failure in the first year after renal transplantation (RT). The purpose of this study was to analyze the incidence of RGN, clinical presentation, and clinical evolution of transplanted renal graft in patients who underwent RT at our center. METHODS: We studied patients with glomerulonephritis (GN) who underwent RT (2007 to 2013).We analyzed sex, age, time in dialysis, type of GN, type of RT, time to post-transplant RGN, kidney function at the time of diagnosis of RGN, and renal graft evolution...
October 2015: Transplantation Proceedings
https://www.readbyqxmd.com/read/26337665/differentiating-glomerular-inflammation-from-fibrosis-in-a-bone-marrow-chimera-for-rat-anti-glomerular-basement-membrane-glomerulonephritis
#7
Cindy Zhou, Kristie Lou, Kiana Tatum, Jeremiah Funk, Jean Wu, Todd Bartkowiak, David Kagan, Yahuan Lou
BACKGROUND: Many types of glomerulonephritis (GN) undergo tandem connected phases: inflammation and fibrosis. Fibrosis in human GNs leads to irreversible end-stage disease. This study investigated how these 2 phases were controlled. METHODS: Using a rat anti-glomerular basement membrane GN model, we established bone marrow (BM) chimeras between GN-resistant Lewis (LEW) and GN-susceptible Wistar Kyoto (WKY) rats. Glomerular inflammation and fibrosis were compared between chimeras...
2015: American Journal of Nephrology
https://www.readbyqxmd.com/read/25644111/neutrophil-extracellular-trap-related-extracellular-histones-cause-vascular-necrosis-in-severe-gn
#8
Santhosh V R Kumar, Onkar P Kulkarni, Shrikant R Mulay, Murthy N Darisipudi, Simone Romoli, Dana Thomasova, Christina R Scherbaum, Bernd Hohenstein, Christian Hugo, Susanna Müller, Helen Liapis, Hans-Joachim Anders
Severe GN involves local neutrophil extracellular trap (NET) formation. We hypothesized a local cytotoxic effect of NET-related histone release in necrotizing GN. In vitro, histones from calf thymus or histones released by neutrophils undergoing NETosis killed glomerular endothelial cells, podocytes, and parietal epithelial cells in a dose-dependent manner. Histone-neutralizing agents such as antihistone IgG, activated protein C, or heparin prevented this effect. Histone toxicity on glomeruli ex vivo was Toll-like receptor 2/4 dependent, and lack of TLR2/4 attenuated histone-induced renal thrombotic microangiopathy and glomerular necrosis in mice...
October 2015: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/25634230/single-dose-rituximab-for-recurrent-glomerulonephritis-post-renal-transplant
#9
Michael L Spinner, Lyndsey J Bowman, Timothy A Horwedel, Rowena B Delos Santos, Christina L Klein, Daniel C Brennan
BACKGROUND/AIMS: Post-renal transplant recurrent glomerulonephritis (GN) contributes to allograft loss. Rituximab treatment has been used in a multidose strategy with variable efficacy and toxicity. We investigated a novel single-dose approach. METHODS: A single center, retrospective, cohort study was conducted between January 1998 and April 2012 among renal allograft recipients with recurrent GN treated with rituximab (cases) or without (controls). The primary outcome was complete response (CR, urine protein/creatinine ratio (UP/C) <0...
2015: American Journal of Nephrology
https://www.readbyqxmd.com/read/25579715/rituximab-as-a-rescue-therapy-in-patients-with-glomerulonephritis
#10
MULTICENTER STUDY
Muhammad Ziad Souqiyyeh, Faissal A M Shaheen, Abdulkareem Alsuwaida, Mohammed Alghonaim, Jamal Alwakeel, Dujana Mosa, Faheem Akhtar, Ebadur Rahman, Maged Husain, Hysam Roujouleh, Nauman Siddiqi, Ibtissam Bukhari, Nihal Sadaqa, Faissal Mushtaque, Neveen Mustafa Awn, Fouad Shariya, Adnan Alfi, Mohammad Amin, Mustafa Ahmad, Fadel Abbas Rowaie, Samir Almueilo, Mohamed Chihab Eddine Kechrid, Ayman Karkar
To evaluate the use of rituximab in the treatment of severe glomerulonephritis (GN) in order to prevent progression of kidney disease toward the end stage, we designed a multicenter, retrospective study in Saudi Arabia about the efficacy and safety of the use of "off label" rituximab in a variety of severe refractory GN to conventional treatment and the progression of kidney disease for at least one year of follow-up. All the patients had kidney biopsies before treatment with rituximab, and proteinuria and glomerular filtration rate (GFR) were followed-up for the period of the study...
January 2015: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/24993947/lupus-like-membranous-nephropathy-is-it-lupus-or-not
#11
Ramin Sam, Amit Joshi, Sam James, Kuang-Yu Jen, Firouz Amani, Peter Hart, Melvin M Schwartz
BACKGROUND: Membranous glomerulonephritis is typically classified as idiopathic or secondary to systemic lupus erythematosus (SLE), hepatitis B, drugs, toxins, other infections, or malignancy. Not infrequently in some patients without a definite diagnosis of SLE, pathologic features of secondary membranous nephropathy are seen e.g., mesangial and/or subendothelial deposits, tubuloreticular inclusions, and full house immunofluorescence. In these patients, there is uncertainty about the etiology, response to therapy, and prognosis of membranous GN...
June 2015: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/24756969/nationwide-biopsy-survey-of-renal-diseases-in-the-czech-republic-during-the-years-1994-2011
#12
Dita Maixnerova, Eva Jancova, Jelena Skibova, Romana Rysava, Ivan Rychlik, Ondrej Viklicky, Miroslav Merta, Alexander Kolsky, Jana Reiterova, Michaela Neprasova, Jana Kidorova, Eva Honsova, Vladimir Tesar
BACKGROUND: We describe data on 10,472 renal biopsies gathered by the Czech Registry of Renal Biopsies over a period of 18 years. METHODS: We assessed the main demographic, clinical and histological data of individuals who underwent renal biopsies of native kidneys in 31 centers in the Czech Republic (population 10.3 million) during the period 1994-2011. RESULTS: We evaluated 10,472 renal biopsies: males 57.8%, children (≤15 years) 13.6%, elderly (>60 years) 19...
February 2015: Journal of Nephrology
https://www.readbyqxmd.com/read/24700867/myeloid-mineralocorticoid-receptor-activation-contributes-to-progressive-kidney-disease
#13
Louis L Huang, David J Nikolic-Paterson, Yingjie Han, Elyce Ozols, Frank Y Ma, Morag J Young, Greg H Tesch
Clinical and experimental studies have shown that mineralocorticoid receptor (MR) antagonists substantially reduce kidney injury. However, the specific cellular targets and mechanisms by which MR antagonists protect against kidney injury must be identified. We used conditional gene deletion of MR signaling in myeloid cells (MR(flox/flox) LysM(Cre) mice; MyMRKO) or podocytes (MR(flox/flox) Pod(Cre) mice; PodMRKO) to establish the role of MR in these cell types in the development of mouse GN. Accelerated anti-glomerular basement membrane GN was examined in groups of mice: MyMRKO, PodMRKO, wild-type (WT) littermates, and WT mice receiving eplerenone (100 mg/kg twice a day; EPL-treated)...
October 2014: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/24231502/pattern-of-glomerular-disease-in-the-saudi-population-a-single-center-five-year-retrospective-study
#14
Z Nawaz, F Mushtaq, D Mousa, E Rehman, M Sulaiman, N Aslam, N Khawaja
Glomerular diseases continue to be the leading cause of end-stage renal disease (ESRD) globally. Hence, it is important to recognize the pattern of glomerular diseases in different geographical areas in order to understand the patho-biology, incidence and progression of the disorder. Published studies from different centers in Saudi Arabia have reported contradicting results. In this retrospective study, we report our experience at the Armed Forces Hospital, Riyadh, Saudi Arabia. A total of 348 native renal biopsies performed at our center on patients with proteinuria >1 g, hematuria and/or renal impairment during a period of 5 years (between January 2005 and December 2009) were studied by a histopathologist using light microscopy, immunofluorescence and electron microscopy, and were categorized...
November 2013: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/23957425/the-clinicopathologic-significance-of-endothelial-tubuloreticular-inclusions-in-glomerular-diseases
#15
Chang-Joo Lee, Kwang-Sun Suh, Kyung-Hee Kim, Yoon-Kyung Chang, Ki-Ryang Na, Kang-Wook Lee
BACKGROUND: The presence of tubuloreticular inclusions (TRIs) in endothelial cells (ECs) always evokes suspicion of an association with underlying viral infections or autoimmune diseases. However, other underlying diseases can be associated with TRI expression. Since identification of the underlying disease is of primary consideration for management of glomerulonephritis (GN), it is important to clarify the clinical significance of TRI expression. METHODS: The authors studied 104 renal biopsy cases having TRI...
December 2013: Ultrastructural Pathology
https://www.readbyqxmd.com/read/23886566/the-modern-spectrum-of-renal-biopsy-findings-in-patients-with-diabetes
#16
Shree G Sharma, Andrew S Bomback, Jai Radhakrishnan, Leal C Herlitz, Michael B Stokes, Glen S Markowitz, Vivette D D'Agati
BACKGROUND AND OBJECTIVES: Renal biopsies performed in diabetic patients are increasing in number and complexity. This study sought to determine the usefulness of renal biopsy in patients with diabetes and the predictability of diagnosing diabetic nephropathy (DN) versus nondiabetic renal disease (NDRD) from clinical and laboratory data. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: To assess modern trends, a retrospective study was performed of clinical-pathologic findings in all patients with diabetes who had a biopsy in 2011...
October 2013: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/23882974/renal-biopsies-in-puerto-rico-patients-with-lupus-nephritis
#17
Vanessa E Rodríguez, Noelia Rodríguez, Angel Mayor, Diana Negrón
The purpose of was to evaluate the renal pathology findings as described by the World Health Organization classification for systemic lupus erythematosus (SLE) in a group of Puerto Rico patients with lupus nephritis and determine the association with clinical and laboratory findings. The medical records from patients seen at the Lu pus Clinic from 1985 to 2005 were reviewed and patients with a performed renal biopsy included. All patients fulfilled the American ColIege of Rheumatology criteria for SLE. Data gathered from the medical records included demographics, cumulative clinical manifestations and serologic tests at the time of the renal biopsy...
April 2012: Boletín de la Asociación Médica de Puerto Rico
https://www.readbyqxmd.com/read/23759297/long-term-kidney-disease-outcomes-in-fibrillary-glomerulonephritis-a-case-series-of-27-patients
#18
Vincent Javaugue, Alexandre Karras, François Glowacki, Brigitte McGregor, Corinne Lacombe, Jean-Michel Goujon, Stéphanie Ragot, Pierre Aucouturier, Guy Touchard, Frank Bridoux
BACKGROUND: Fibrillary glomerulonephritis (GN) is a rare disorder with poor renal prognosis. Therapeutic strategies, particularly the use of immunosuppressive drugs, are debated. STUDY DESIGN: Case series. SETTING & PARTICIPANTS: 27 adults with fibrillary GN referred to 15 nephrology departments in France between 1990 and 2011 were included. All patients were given renin-angiotensin system blockers and 13 received immunosuppressive therapy, including rituximab (7 patients) and cyclophosphamide (3 patients)...
October 2013: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/23659154/-primary-glomerulonephritis-in-focus
#19
Vincent Bourquin, Belén Ponte, Micheal Zellweger, Marc Levy, Solange Moll
The glomerulonephritis (GN) are responsible for a significant amount of end stage renal disease. They may be secondary to another disease or idiopathic. When a secondary etiology has been excluded, it is called primary glomerulonephritis (PGN). Glomerular damage may have different presentations and there are many way to classify them. It is thus difficult for the non-specialist to understand the terminology used. This article is a summary of the most frequently encountered PGN such as: IgA nephropathy, membranous GN, idiopathic nephrotic syndrome, extracapillary and membranoproliferative GN...
April 10, 2013: Revue Médicale Suisse
https://www.readbyqxmd.com/read/23252627/ribosomal-protein-s19-is-a-novel-therapeutic-agent-in-inflammatory-kidney-disease
#20
Jun Lv, Xiao Ru Huang, Jörg Klug, Suada Fröhlich, Philipp Lacher, Anping Xu, Andreas Meinhardt, Hui Yao Lan
RPS19 (ribosomal protein S19), a component of the 40S small ribosomal subunit, has recently been identified to bind the pro-inflammatory cytokine macrophage MIF (migration inhibitory factor). In vitro experiments identify RPS19 as the first endogenous MIF inhibitor by blocking the binding of MIF to its receptor CD74 and MIF functions on monocyte adherence to endothelial cells. In the present study, we sought to establish whether recombinant RPS19 can exert anti-inflammatory effects in a mouse model of anti-GBM (glomerular basement membrane) GN (glomerulonephritis) in which MIF is known to play an important role...
May 2013: Clinical Science (1979-)
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