Xiao Ma, Seethalakshmi R Iyer, Xiaoyu Ma, Shawn H Reginauld, Yang Chen, Shuchong Pan, Ye Zheng, Dante Moroni, Yue Yu, Lianwen Zhang, Valentina Cannone, Horng H Chen, Carlos M Ferrario, S Jeson Sangaralingham, John C Burnett
BACKGROUND: Natriuretic peptide system (NPS) and renin angiotensin aldosterone system (RAAS) function oppositely at multiple levels. While it has long been suspected that angiotensin II (ANGII) may directly suppress NPS activity, no clear evidence to date support this notion. OBJECTIVES: This study was designed to systematically investigate ANGII-NPS interaction in humans, in vivo, and in vitro for translational insights. METHODS: Circulating atrial, b-type, and c-type natriuretic peptides (ANP, BNP, CNP), cyclic guanosine monophosphate (cGMP), and ANGII were simultaneously investigated in 128 human subjects...
January 27, 2023: bioRxiv