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https://www.readbyqxmd.com/read/28812028/expression-profile-of-genes-potentially-associated-with-adequate-glycemic-control-in-patients-with-type-2-diabetes-mellitus
#1
Sâmia Cruz Tfaile Corbi, Alliny Souza Bastos, Rafael Nepomuceno, Thamiris Cirelli, Raquel Alves Dos Santos, Catarina Satie Takahashi, Cristiane S Rocha, Silvana Regina Perez Orrico, Claudia V Maurer-Morelli, Raquel Mantuaneli Scarel-Caminaga
Despite increasing research in type 2 diabetes mellitus (T2D), there are few studies showing the impact of the poor glycemic control on biological processes occurring in T2D. In order to identify potential genes related to poorly/well-controlled patients with T2D, our strategy of investigation included a primary screen by microarray (Human Genome U133) in a small group of individuals followed by an independent validation in a greater group using RT-qPCR. Ninety patients were divided as follows: poorly controlled T2D (G1), well-controlled T2D (G2), and normoglycemic individuals (G3)...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28803410/an-investigation-of-moral-principles-and-mental-training-in-the-p%C3%A4-li-nik%C3%A4-yas-and-their-implications-for-behaviour-modification-and-mental-health
#2
Ashin Sumanacara
This article explicates the fundamental moral principles and mental training of Buddhism that have implications for behavioural transformation and mental health promotion. These techniques are considered to be effective for transforming the unwholesome thoughts and overcoming the afflictions (āsavas). It investigates some methods of mental training that can be designed to fit the behaviour of a practitioner. It also investigates the three key interdependent elements of mindfulness techniques and, in particular, how a simple practice of mindfulness (sati), full awareness (sampajañña), and proper attention (yoniso-manasikāra) can help us modify our behaviour and achieve mental health...
August 12, 2017: Journal of Religion and Health
https://www.readbyqxmd.com/read/28800408/effects-of-phenanthrene-on-early-development-of-the-pacific-oyster-crassostrea-gigas-thunberg-1789
#3
Diego J Nogueira, Jacó J Mattos, Patrick R Dybas, Fabrıcio Flores-Nunes, Silvio Tarou Sasaki, Satie Taniguchi, Éder C Schmidt, Zenilda L Bouzon, Márcia C Bícego, Claudio M R Melo, Guilherme Toledo-Silva, Afonso C D Bainy
Phenanthnere (PHE) is a polycyclic aromatic hydrocarbon continuously discarded in the marine environment and bioavailable to many aquatic species. Although studies about PHE toxicity have been documented for adult oysters, the effects on early developmental stages are poorly characterized in bivalves. In this study, the effects of PHE (0.02 and 2.0μg.L(-1)) were evaluated on the embryogenesis and larval development of Crassostrea gigas. Toxicity bioassays, growth and deformities assessment, analysis of shell calcium abundance and transcript levels of genes related to xenobiotic biotransformation (CYP2AU2, CYP30C1), immune system (Cg-Tal) and tissue growth and shell formation (Ferritin, Insulin-like, Cg-Try, Calmodulin and Nacrein) were assayed in D-shape larvae after 24h of PHE exposure...
August 1, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28796432/7t-mri-visualization-of-cortical-lesions-in-adolescents-and-young-adults-with-pediatric-onset-multiple-sclerosis
#4
Ritobrato Datta, Varun Sethi, Sophia Ly, Amy T Waldman, Sona Narula, Blake E Dewey, Pascal Sati, Daniel Reich, Brenda Banwell
BACKGROUND: Cortical pathology in multiple sclerosis (MS) has been associated with prolonged and progressive disease. 7T magnetic resonance imaging (MRI) provides enhanced visualization of cortical lesions (CLs). Hence, we conducted a pilot study to explore whether CLs occur early in MS, as evidenced by pediatric-onset patients. METHODS: A total of 8 pediatric-onset MS patients were imaged using 7T MRI. CLs were annotated on T1-weighted magnetization-prepared rapid acquisition of gradient echoes images as leukocortical (LC), intracortical, or subpial...
August 10, 2017: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/28790784/a-clinical-correlation-of-conjunctival-microangiopathy-with-grades-of-retinopathy-in-type-2-diabetes-mellitus
#5
M A Khan, Manasa Katta, V S Gurunadh, P S Moulick, Sandeep Gupta, Alok Sati
BACKGROUND: Conjunctival microangiopathy has been described among diabetics similar to retinal vessel angiopathy. Correlation of these conjunctival microangiopathy changes with retinopathy may form the basis of screening by external examination without expert fundus evaluation. METHODS: Conjunctival vessels widths and tortuous segment length of conjunctival vessels of 96 patients with type 2 diabetes mellitus were photographed and measured by the Zeiss Fundus camera Visupac software...
July 2017: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/28746570/brazilian-guidelines-for-the-clinical-management-of-paracoccidioidomycosis
#6
Maria Aparecida Shikanai-Yasuda, Rinaldo Pôncio Mendes, Arnaldo Lopes Colombo, Flávio de Queiroz-Telles, Adriana Satie Gonçalves Kono, Ana Maria Paniago, André Nathan, Antonio Carlos Francisconi do Valle, Eduardo Bagagli, Gil Benard, Marcelo Simão Ferreira, Marcus de Melo Teixeira, Mario León Silva-Vergara, Ricardo Mendes Pereira, Ricardo de Souza Cavalcante, Rosane Hahn, Rui Rafael Durlacher, Zarifa Khoury, Zoilo Pires de Camargo, Maria Luiza Moretti, Roberto Martinez
Paracoccidioidomycosis is a systemic fungal disease occurring in Latin America that is associated with rural environments and agricultural activities. However, the incidence and prevalence of paracoccidiodomycosis is underestimated because of the lack of compulsory notification. If paracoccidiodomycosis is not diagnosed and treated early and adequately, the endemic fungal infection could result in serious sequelae. While the Paracoccidioides brasiliensis ( P. brasiliensis ) complex has been known to be the causal agent of paracoccidiodomycosis, a new species, Paracoccidioides lutzii ( P...
July 20, 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28729482/brca1-and-brca2-tumor-suppressors-protect-against-endogenous-acetaldehyde-toxicity
#7
Eliana Mc Tacconi, Xianning Lai, Cecilia Folio, Manuela Porru, Gijs Zonderland, Sophie Badie, Johanna Michl, Irene Sechi, Mélanie Rogier, Verónica Matía García, Ankita Sati Batra, Oscar M Rueda, Peter Bouwman, Jos Jonkers, Anderson Ryan, Bernardo Reina-San-Martin, Joannie Hui, Nelson Tang, Alejandra Bruna, Annamaria Biroccio, Madalena Tarsounas
Maintenance of genome integrity requires the functional interplay between Fanconi anemia (FA) and homologous recombination (HR) repair pathways. Endogenous acetaldehyde, a product of cellular metabolism, is a potent source of DNA damage, particularly toxic to cells and mice lacking the FA protein FANCD2. Here, we investigate whether HR-compromised cells are sensitive to acetaldehyde, similarly to FANCD2-deficient cells. We demonstrate that inactivation of HR factors BRCA1, BRCA2, or RAD51 hypersensitizes cells to acetaldehyde treatment, in spite of the FA pathway being functional...
July 20, 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28721740/clinical-features-and-subjective-physiological-responses-to-emotional-stimuli-in-the-presence-of-emotion-dysregulation-in-attention-deficit-hyperactivity-disorder
#8
Candan Taskiran, Serkan Karaismailoglu, Halime Tuna Cak Esen, Zeynep Tuzun, Aysen Erdem, Zeynep Dicle Balkanci, Anil Barak Dolgun, Sadriye Ebru Cengel Kultur
INTRODUCTION: Emotion dysregulation (ED) has long been recognized in clinical descriptions of attention-deficit hyperactivity disorder (ADHD), but a renewed interest in ED has advanced research on the overlap between the two entities. Autonomic reactivity (AR) is a neurobiological correlate of emotion regulation; however, the association between ADHD and AR remains unclear. Our aim was to explore the clinical differences, AR, and subjective emotional responses to visual emotional stimuli in ADHD children with and without ED...
July 19, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/28702353/longitudinal-mr-spectroscopy-of-neurodegeneration-in-multiple-sclerosis-with-diffusion-of-the-intra-axonal-constituent-n-acetylaspartate
#9
Emily Turner Wood, Ece Ercan, Pascal Sati, Irene C M Cortese, Itamar Ronen, Daniel S Reich
Multiple sclerosis (MS) is a pathologically complex CNS disease: inflammation, demyelination, and neuroaxonal degeneration occur concurrently and may depend on one another. Current therapies are aimed at the immune-mediated, inflammatory destruction of myelin, whereas axonal degeneration is ongoing and not specifically targeted. Diffusion-weighted magnetic resonance spectroscopy can measure the diffusivity of metabolites in vivo, such as the axonal/neuronal constituent N-acetylaspartate, allowing compartment-specific assessment of disease-related changes...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28695266/erratum-to-is-there-any-benefit-using-low-intensity-inspiratory-and-peripheral-muscle-training-in-heart-failure-a-randomized-clinical-trial
#10
Tatiana Satie Kawauchi, Iracema Ioco Kikuchi Umeda, Lays Magalhães Braga, Antonio de Pádua Mansur, João Manoel Rossi-Neto, Amanda Guerra de Moraes Rego Sousa, Mário Hiroyuki Hirata, Lawrence P Cahalin, Naomi Kondo Nakagawa
No abstract text is available yet for this article.
July 10, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28693879/profiles-of-the-patient-who-had-compulsory-hospitalization-in-a-district-psychiatric-hospital
#11
Nalan Gördeles Beşer, Leyla Baysan Arabaci, Satı Bozkurt, Gülçin Uzunoğlu, Gülsenay Taş
OBJECTIVE: It aims to examine the profiles of patients who were treated with compulsory hospitalization between 2011 and 2015 in a district psychiatric hospital. METHOD: In this retrospective and cohort study, hospital records gathered from 202 adult patients who were treated with compulsory hospitalization in units with a bed between 2011 and 2015 in a district psychiatric hospital were examined. In this study, profiles and socio-demographic features of the patients with compulsory hospitalization were evaluated by 23 closed-end and open-ended questions prepared by researchers...
August 2017: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/28687996/distribution-and-evolution-of-sterols-and-aliphatic-hydrocarbons-in-dated-marine-sediment-cores-from-the-cabo-frio-upwelling-region-sw-atlantic-brazil
#12
Rafael André Lourenço, César C Martins, Satie Taniguchi, Michel Michaelovitch Mahiques, Rosalinda Carmela Montone, Caio Augusto Magalhães, Márcia Caruso Bícego
We report the distribution of selected lipid biomarkers specifically sterols and aliphatic hydrocarbons in sediment cores from Cabo Frio, SW Atlantic continental shelf, Brazil, corresponding approximately to the last 700 years. In the Cabo Frio region, a costal upwelling occurs as a quasi-seasonal phenomenon characterized by nutrient-rich bottom waters that intrude on the continental shelf and promote relatively high biological productivity compared to other Brazilian continental shelf areas. The results for sterols indicate the predominance of organic matter (OM) inputs related to marine organisms, mainly plankton, in all of the cores along the time scale studied...
July 7, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28679482/colour-spectrum-and-resin-type-determine-the-concentration-and-composition-of-polycyclic-aromatic-hydrocarbons-pahs-in-plastic-pellets
#13
Mara Fisner, Alessandra Majer, Satie Taniguchi, Márcia Bícego, Alexander Turra, Daniel Gorman
This study assessed the concentration and composition of Polycyclic Aromatic Hydrocarbons (PAHs) in plastic pellets, collected from sandy beaches and considered different resin and colour tones. Results showed that polyethylene pellets, while displaying a greater range of total PAH concentrations did not differ significantly from polypropylene pellets. More importantly, both resin types demonstrated predictable increases in total PAH across a spectrum of darkening colour tones. Multivariate comparisons of 36 PAH groups, further showed considerable variability across resin type and colour, with lighter coloured pellets comprising lower molecular weight, while darker pellets contained higher weight PAHs...
July 3, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28631123/modeling-solubility-of-co2-hydrocarbon-gas-in-ionic-liquid-emim-fap-using-aspen-plus-simulations
#14
Bishwadeep Bagchi, Sushmita Sati, Vidyasagar Shilapuram
The Peng-Robinson equation of state with quadratic van der Waals (vdW) mixing rule model was chosen to perform the thermodynamic calculations in Flash3 column of Aspen Plus to predict the solubility of CO2 or any one of the hydrocarbons (HCs) among methane, ethane, propane, and butane in an ionic liquid 1-ethyl-3-methylimidazolium tris(pentafluoroethyl)trifluorophosphate ([emim][FAP]). Bubble point pressure, solubility, bubble point temperature, fugacity, and partial molar volume at infinite dilution were obtained from the simulations, and enthalpy of absorption, Gibbs free energy of solvation, and entropy change of absorption were estimated by thermodynamic relations...
June 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28588319/subcutaneous-adiposity-is-an-independent-predictor-of-mortality-in-cancer-patients
#15
Maryam Ebadi, Lisa Martin, Sunita Ghosh, Catherine J Field, Richard Lehner, Vickie E Baracos, Vera C Mazurak
BACKGROUND: Prognostic significance of adiposity, at the time of cancer diagnosis, on survival is not clear. Body mass index (kg m(-2)) does not provide an appropriate assessment of body composition; therefore, the concept of the 'obesity paradox' needs to be investigated based on the prognostic significance of fat and muscle. Independent prognostic significance of adipose tissue in predicting mortality, importance of visceral and subcutaneous adiposity in the presence and absence of sarcopenia on survival, was investigated...
June 27, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28553723/two-antidiabetic-constituents-from-roylea-cinerea-d-don-baill
#16
U P Bhatt, S C Sati, R P Bahuguna, R B Semwal, D K Semwal
Two antidiabetic compounds named 4-methoxybenzo[b]azet-2(1H)-one (1) and 3β-hydroxy-35-(cyclohexyl-5'-propan-7'-one)-33-ethyl-34-methyl-bacteriohop-16-ene (2) together with stigmasterol and β-sitosterol were isolated from the aerial part of Roylea cinerea (D.Don) Baill. The structures of these compounds were elucidated by advanced spectroscopic methods, including two-dimensional NMR and MS techniques. These compounds were evaluated for their antidiabetic efficacy using in vitro and in vivo methods. Both compounds (1 and 2) showed a significant decline in blood glucose level of alloxan-induced diabetic rats at 10 mg/kg, p...
May 29, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28527999/nanocellulose-collagen-apatite-composite-associated-with-osteogenic-growth-peptide-for-bone-regeneration
#17
Sybele Saska, Lucas Novaes Teixeira, Larissa Moreira Spinola de Castro Raucci, Raquel Mantuaneli Scarel-Caminaga, Leonardo Pereira Franchi, Raquel Alves Dos Santos, Silvia Helena Santagneli, Marisa Veiga Capela, Paulo Tambasco de Oliveira, Catarina Satie Takahashi, Ana Maria Minarelli Gaspar, Younès Messaddeq, Sidney José Lima Ribeiro, Reinaldo Marchetto
Despite advances in the field of biomaterials for bone repair/regeneration, some challenges for developing an ideal bone substitute need to be overcome. Herein, this study synthesized and evaluated in vitro a nanocomposite based on bacterial cellulose (BC), collagen (COL), apatite (Ap) and osteogenic growth peptide (OGP) or its C-terminal pentapeptide [OGP(10-14)] for bone regeneration purposes. The BC-COL nanocomposites were successfully obtained by carbodiimide-mediated coupling as demonstrated by spectroscopy analysis...
October 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28409356/flair-to-visualize-veins-in-white-matter-lesions-a-new-tool-for-the-diagnosis-of-multiple-sclerosis
#18
T Campion, R J P Smith, D R Altmann, G C Brito, B P Turner, J Evanson, I C George, P Sati, D S Reich, M E Miquel, K Schmierer
OBJECTIVE: To explore the potential of a post-processing technique combining FLAIR and T2* (FLAIR*) to distinguish between lesions caused by multiple sclerosis (MS) from cerebral small vessel disease (SVD) in a clinical setting. METHODS: FLAIR and T2* head datasets acquired at 3T of 25 people with relapsing MS (pwRMS) and ten with pwSVD were used. After post-processing, FLAIR* maps were used to determine the proportion of white matter lesions (WML) showing the 'vein in lesion' sign (VIL), a characteristic histopathological feature of MS plaques...
April 13, 2017: European Radiology
https://www.readbyqxmd.com/read/28391792/insights-from-ultrahigh-field-imaging-in-multiple-sclerosis
#19
REVIEW
Matthew K Schindler, Pascal Sati, Daniel S Reich
Ultrahigh-field (≥7 T) magnetic resonance (MR) imaging is being used at many leading academic medical centers to study neurologic disorders. The improved spatial resolution and anatomic detail are due to the increase in signal-to-noise and contrast-to-noise ratio at higher magnetic field strengths. Ultrahigh-field MR imaging improves multiple sclerosis (MS) lesion detection, with particular sensitivity to detect cortical lesions. The increase in magnetic susceptibility effects inherent to ultrahigh field can be used to detect pathologic features of MS lesions, including a central vein, potentially useful for diagnostic considerations, and heterogeneity among MS lesions, potentially useful in determining lesion outcomes...
May 2017: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/28343384/n6-n6-and-o4-modifications-to-neomycin-affect-ribosomal-selectivity-without-compromising-antibacterial-activity
#20
Girish C Sati, Dimitri Shcherbakov, Sven N Hobbie, Andrea Vasella, Erik C Böttger, David Crich
The synthesis of a series of neomycin derivatives carrying the 2-hydroxyethyl substituent on N6' and/or N6‴ both alone and in combination with a 4'-O-ethyl group is described. By means of cell-free translation assays with wild-type bacterial ribosomes and their hybrids with eukaryotic decoding A sites, we investigate how individual substituents and their combinations affect activity and selectivity at the target level. In principle, and as shown by cell-free translation assays, modifications of the N6' and N6‴ positions allow enhancement of target selectivity without compromising antibacterial activity...
May 12, 2017: ACS Infectious Diseases
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