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https://www.readbyqxmd.com/read/28076645/is-there-a-correlation-between-physicians-clinical-impressions-and-patients-perceptions-of-change-use-of-the-perceived-change-scale-with-inpatients-with-mental-disorders
#1
Gabriela Pavan, Julia Almeida Godoy, Ricardo Tavares Monteiro, Hugo Karling Moreschi, Eduardo Lopes Nogueira, Lucas Spanemberg
Introduction: Assessment of the results of treatment for mental disorders becomes more complete when the patient's perspective is incorporated. Here, we aimed to evaluate the psychometric properties and application of the Perceived Change Scale - Patient version (PCS-P) in a sample of inpatients with mental disorders. Methods: One hundred and ninety-one psychiatric inpatients answered the PCS-P and the Patients' Satisfaction with Mental Health Services Scale (SATIS) and were evaluated in terms of clinical and sociodemographic data...
October 2016: Trends in Psychiatry and Psychotherapy
https://www.readbyqxmd.com/read/28060281/utilizing-3d-printing-technology-to-merge-mri-with-histology-a-protocol-for-brain-sectioning
#2
Nicholas J Luciano, Pascal Sati, Govind Nair, Joseph R Guy, Seung-Kwon Ha, Martina Absinta, Wen-Yang Chiang, Emily C Leibovitch, Steven Jacobson, Afonso C Silva, Daniel S Reich
Magnetic resonance imaging (MRI) allows for the delineation between normal and abnormal tissue on a macroscopic scale, sampling an entire tissue volume three-dimensionally. While MRI is an extremely sensitive tool for detecting tissue abnormalities, association of signal changes with an underlying pathological process is usually not straightforward. In the central nervous system, for example, inflammation, demyelination, axonal damage, gliosis, and neuronal death may all induce similar findings on MRI. As such, interpretation of MRI scans depends on the context, and radiological-histopathological correlation is therefore of the utmost importance...
December 6, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28040644/transcriptional-changes-in-oysters-crassostrea-brasiliana-exposed-to-phenanthrene-at-different-salinities
#3
Flávia Lucena Zacchi, Daína de Lima, Fabrício Flores-Nunes, Jacó Joaquim Mattos, Karim Hahn Lüchmann, Carlos Henrique Araújo de Miranda Gomes, Márcia Caruso Bícego, Satie Taniguchi, Silvio Tarou Sasaki, Afonso Celso Dias Bainy
Euryhaline animals from estuaries, such as the oyster Crassostrea brasiliana, show physiological mechanisms of adaptation to tolerate salinity changes. These ecosystems receive constant input of xenobiotics from urban areas, including polycyclic aromatic hydrocarbons (PAHs), such as phenanthrene (PHE). In order to understand the influence of salinity on the molecular responses of C. brasiliana exposed to PHE, oysters were acclimatized to different salinities (35, 25 and 10) for 15days and then exposed to 100μgL(-1) PHE for 24h and 96h...
December 21, 2016: Aquatic Toxicology
https://www.readbyqxmd.com/read/28039330/dissecting-the-influence-of-two-structural-substituents-on-the-differential-neurotoxic-effects-of-methamphetamine-and-mephedrone-on-dopamine-nerve-endings-with-the-use-of-4-methylmethamphetamine-and-methcathinone
#4
John H Anneken, Mariana Angoa-Perez, Girish C Sati, David Crich, Donald M Kuhn
Mephedrone (MEPH) is a β-ketoamphetamine stimulant drug of abuse that is often a constituent of illicit bath salts formulations. While MEPH bears remarkable similarities to methamphetamine (METH) in terms of chemical structure, as well as its neurochemical and behavioral effects, it has been shown to have a reduced neurotoxic profile compared to METH. The addition of a β-keto moiety and a 4-methyl ring substituent to METH yields MEPH, and a loss of direct neurotoxic potential. In the present study, 2 analogs of METH, methcathinone (MeCa) and 4-methylmethamphetamine (4MM), were assessed for their effects on mouse dopamine (DA) nerve endings to determine the relative contribution of each individual moiety to the loss of direct neurotoxicity in MEPH...
December 30, 2016: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/27992986/-effect-of-genetics-epigenetics-and-variations-in-the-transcriptional-expression-of-cadherin-e-in-breast-cancer-susceptibility
#5
Andrés Felipe Aristizábal-Pachón, Catarina Satie Takahashi
INTRODUCTION: Cadherin-E (CDH1) is an important regulator of epithelial-mesenchymal transition, invasion and metastasis in many carcinomas. However, germinal epimutations and mutations effect in breast cancer susceptibility is not clear. OBJECTIVE: To evaluate rs334558 polymorphism, promoter methylation status and CDH1 expression profile in breast cancer patients. MATERIALS AND METHODS: We collected peripheral blood samples from 102 breast cancer patients and 102 healthy subjects...
December 1, 2016: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/27936043/reproducibility-for-heart-rate-variability-analysis-during-6-min-walk-test-in-patients-with-heart-failure-and-agreement-between-devices
#6
Lays Magalhães Braga, Gustavo Faibischew Prado, Iracema Ioco Kikuchi Umeda, Tatiana Satie Kawauchi, Adriana Marques Fróes Taboada, Raymundo Soares Azevedo, Horacio Gomes Pereira Filho, César José Grupi, Hayala Cristina Cavenague Souza, Dalmo Antônio Ribeiro Moreira, Naomi Kondo Nakagawa
Heart rate variability (HRV) analysis is a useful method to assess abnormal functioning in the autonomic nervous system and to predict cardiac events in patients with heart failure (HF). HRV measurements with heart rate monitors have been validated with an electrocardiograph in healthy subjects but not in patients with HF. We explored the reproducibility of HRV in two consecutive six-minute walk tests (6MW), 60-minute apart, using a heart rate monitor (PolarS810i) and a portable electrocardiograph (called Holter) in 50 HF patients (mean age 59 years, NYHA II, left ventricular ejection fraction ~35%)...
2016: PloS One
https://www.readbyqxmd.com/read/27880997/efficacy-of-switching-from-adefovir-to-tenofovir-in-chronic-hepatitis-b-patients-who-exhibit-suboptimal-responses-to-adefovir-based-combination-rescue-therapy-due-to-resistance-to-nucleoside-analogues-satis-study
#7
Hye Won Lee, Jun Yong Park, Beom Kyung Kim, Moon Young Kim, Jung Il Lee, Young Suk Kim, Ki Tae Yoon, Kwang-Hyub Han, Sang Hoon Ahn
BACKGROUND/AIMS: It remains to be determined whether switching from adefovir (ADV) to tenofovir (TDF) provides better virological outcomes in patients exhibiting suboptimal responses to ADV plus nucleoside analogue (ADV+NA) therapy for NA-resistant chronic hepatitis B (CHB). METHODS: In this prospective trial, patients who showed partial responses (defined as serum hepatitis B virus [HBV] DNA >60 IU/mL) to ADV+NA therapy for NA resistance were randomly allocated to receive TDF plus NA (TDF+NA group, n=16) or to continue their current therapy (ADV+NA group, n=16)...
December 2016: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/27843192/unique-presentation-of-ophthalmia-nodosa-in-an-adult-male-patient-with-a-novel-management-approach
#8
Sandeep Shankar, T S Ahluwalia, V S Gurunadh, Alok Sati
No abstract text is available yet for this article.
October 2016: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/27834394/the-central-vein-sign-and-its-clinical-evaluation-for-the-diagnosis-of-multiple-sclerosis-a-consensus-statement-from-the-north-american-imaging-in-multiple-sclerosis-cooperative
#9
Pascal Sati, Jiwon Oh, R Todd Constable, Nikos Evangelou, Charles R G Guttmann, Roland G Henry, Eric C Klawiter, Caterina Mainero, Luca Massacesi, Henry McFarland, Flavia Nelson, Daniel Ontaneda, Alexander Rauscher, William D Rooney, Amal P R Samaraweera, Russell T Shinohara, Raymond A Sobel, Andrew J Solomon, Constantina A Treaba, Jens Wuerfel, Robert Zivadinov, Nancy L Sicotte, Daniel Pelletier, Daniel S Reich
Over the past few years, MRI has become an indispensable tool for diagnosing multiple sclerosis (MS). However, the current MRI criteria for MS diagnosis have imperfect sensitivity and specificity. The central vein sign (CVS) has recently been proposed as a novel MRI biomarker to improve the accuracy and speed of MS diagnosis. Evidence indicates that the presence of the CVS in individual lesions can accurately differentiate MS from other diseases that mimic this condition. However, the predictive value of the CVS for the development of clinical MS in patients with suspected demyelinating disease is still unknown...
November 11, 2016: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/27800425/the-use-of-ascorbic-acid-as-a-food-additive-technical-legal-issues
#10
Michele Varvara, Giancarlo Bozzo, Giuseppe Celano, Chiara Disanto, Cosimo Nicola Pagliarone, Gaetano Vitale Celano
Ascorbic acid (C6H8O6) is an organic compound belonging to the family of monosaccharide. It is highly soluble in water, and is often called one of the secrets of the Mediterranean diet. Its use is widespread in the food industry is also important, having always been exploited for its antioxidant and stabilising ability. Many indeed are the additive formulations that take advantage of these properties. The purpose of this paper is to explain the characteristics that make ascorbic acid an important food additive and to emphasise the technical and legal issues related to its use in food productions...
January 18, 2016: Italian Journal of Food Safety
https://www.readbyqxmd.com/read/27797180/sensitive-detection-of-polynucleotide-kinase-activity-by-paper-based-fluorescence-assay-with-%C3%AE-exonuclease-assistance
#11
Hua Zhang, Zhen Zhao, Zhen Lei, Zhenxin Wang
The phosphorylation of nucleic acid with 5'-OH termini catalyzed by polynucleotide kinase (PNK) involves several significant cellular events. Here a paper-based fluorescence assay with λ exonuclease assistance was reported for facile detection of PNK activity through monitoring the change of fluorescence intensity on paper surface. Cy5-labeled ssDNA was first immobilized on the surface of aldehyde group modified paper, and BHQ-labeled ssDNA was then employed to quench the fluorescence of the immobilized Cy5-labeled ssDNA with the help of an adaptor ssDNA...
December 6, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27743612/magnetic-resonance-imaging-of-experimental-autoimmune-encephalomyelitis-in-the-common-marmoset
#12
Pietro Maggi, Pascal Sati, Luca Massacesi
Magnetic resonance imaging (MRI) is an invaluable tool for the diagnosis and monitoring of patients with multiple sclerosis (MS) as well as for the study of the disease pathophysiology. Because of its strong clinical, radiological and histopathological similarities with the human disease, experimental autoimmune encephalomyelitis (EAE) in the common marmoset has been studied more intensively over the past several years. Here, we review the current knowledge on MRI in the marmoset EAE, and we outline the physiopathological significance and translational values of these studies with respect to MS...
October 8, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/27723466/effects-of-harbor-activities-on-sediment-quality-in-a-semi-arid-region-in-brazil
#13
Lucas B Moreira, Ítalo B Castro, Marcos A Hortellani, Silvio T Sasaki, Satie Taniguchi, Mônica A V Petti, Gilberto Fillmann, Jorge E S Sarkis, Márcia C Bícego, Leticia V Costa-Lotufo, Denis M S Abessa
Tropical marine environments are rich in biodiversity and the presence of harbor activities in these areas can harm the coastal ecosystems. In this study, we assessed sediment quality of two harbors from a tropical region in Brazil by applying multiple lines-of-evidence approach. This approach included the integration of results on: (1) grain size, organic matter, organic carbon, nitrogen, phosphorus, trace metals, polycyclic aromatic hydrocarbons, linear alkylbenzenes, and tributyltin; (2) acute toxicity of whole sediments and chronic toxicity of liquid phases; and (3) benthic community descriptors...
January 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27722085/statistical-estimation-of-white-matter-microstructure-from-conventional-mri
#14
Leah H Suttner, Amanda Mejia, Blake Dewey, Pascal Sati, Daniel S Reich, Russell T Shinohara
Diffusion tensor imaging (DTI) has become the predominant modality for studying white matter integrity in multiple sclerosis (MS) and other neurological disorders. Unfortunately, the use of DTI-based biomarkers in large multi-center studies is hindered by systematic biases that confound the study of disease-related changes. Furthermore, the site-to-site variability in multi-center studies is significantly higher for DTI than that for conventional MRI-based markers. In our study, we apply the Quantitative MR Estimation Employing Normalization (QuEEN) model to estimate the four DTI measures: MD, FA, RD, and AD...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27714649/telephone-delivered-stepped-collaborative-care-for-treating-anxiety-in-primary-care-a-randomized-controlled-trial
#15
Bruce L Rollman, Bea Herbeck Belnap, Sati Mazumdar, Kaleab Z Abebe, Jordan F Karp, Eric J Lenze, Herbert C Schulberg
BACKGROUND: Collaborative care for depression is more effective in improving treatment outcomes than primary care physicians' (PCPs) usual care (UC). However, few trials of collaborative care have targeted anxiety. OBJECTIVE: To examine the impact and 12-month durability of a centralized, telephone-delivered, stepped collaborative care intervention (CC) for treating anxiety disorders across a network of primary care practices. DESIGN: Randomized controlled trial with blinded outcome assessments...
October 6, 2016: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/27702751/patient-derived-tumour-xenografts-for-breast-cancer-drug-discovery
#16
REVIEW
John W Cassidy, Ankita S Batra, Wendy Greenwood, Alejandra Bruna
Despite remarkable advances in our understanding of the drivers of human malignancies, new targeted therapies often fail to show sufficient efficacy in clinical trials. Indeed, the cost of bringing a new agent to market has risen substantially in the last several decades, in part fuelled by extensive reliance on preclinical models that fail to accurately reflect tumour heterogeneity. To halt unsustainable rates of attrition in the drug discovery process, we must develop a new generation of preclinical models capable of reflecting the heterogeneity of varying degrees of complexity found in human cancers...
December 2016: Endocrine-related Cancer
https://www.readbyqxmd.com/read/27693009/mugil-curema-as-a-pah-bioavailability-monitor-for-atlantic-west-sub-tropical-estuaries
#17
Ana Cecília Rizzatti de Albergaria-Barbosa, Vinicius Faria Patire, Satie Taniguchi, Wellington Silva Fernandez, June Ferraz Dias, Márcia Caruso Bícego
This work aimed to evaluate the use of Mugil curema as a biomonitor for polycyclic aromatic hydrocarbon (PAH) bioavailability. Fish biliary metabolites from low-contaminated (Cananéia) and contaminated (Santos) Brazilian estuaries were analysed using a high-performance liquid chromatography apparatus coupled to fluorescence detectors connected in a series. In the Cananéia and Santos estuaries, total metabolite levels ranged from 0.85 to 34.4μgg(-1) of bile and from 4.06 to 528μgg(-1) of bile, respectively...
January 15, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/27643538/coordinate-redeployment-of-prc1-proteins-suppresses-tumor-formation-during-drosophila-development
#18
Vincent Loubiere, Anna Delest, Aubin Thomas, Boyan Bonev, Bernd Schuettengruber, Satish Sati, Anne-Marie Martinez, Giacomo Cavalli
Polycomb group proteins form two main complexes, PRC2 and PRC1, which generally coregulate their target genes. Here we show that PRC1 components act as neoplastic tumor suppressors independently of PRC2 function. By mapping the distribution of PRC1 components and trimethylation of histone H3 at Lys27 (H3K27me3) across the genome, we identify a large set of genes that acquire PRC1 in the absence of H3K27me3 in Drosophila larval tissues. These genes massively outnumber canonical targets and are mainly involved in the regulation of cell proliferation, signaling and polarity...
November 2016: Nature Genetics
https://www.readbyqxmd.com/read/27641504/a-biobank-of-breast-cancer-explants-with-preserved-intra-tumor-heterogeneity-to-screen-anticancer-compounds
#19
Alejandra Bruna, Oscar M Rueda, Wendy Greenwood, Ankita Sati Batra, Maurizio Callari, Rajbir Nath Batra, Katherine Pogrebniak, Jose Sandoval, John W Cassidy, Ana Tufegdzic-Vidakovic, Stephen-John Sammut, Linda Jones, Elena Provenzano, Richard Baird, Peter Eirew, James Hadfield, Matthew Eldridge, Anne McLaren-Douglas, Andrew Barthorpe, Howard Lightfoot, Mark J O'Connor, Joe Gray, Javier Cortes, Jose Baselga, Elisabetta Marangoni, Alana L Welm, Samuel Aparicio, Violeta Serra, Mathew J Garnett, Carlos Caldas
The inter- and intra-tumor heterogeneity of breast cancer needs to be adequately captured in pre-clinical models. We have created a large collection of breast cancer patient-derived tumor xenografts (PDTXs), in which the morphological and molecular characteristics of the originating tumor are preserved through passaging in the mouse. An integrated platform combining in vivo maintenance of these PDTXs along with short-term cultures of PDTX-derived tumor cells (PDTCs) was optimized. Remarkably, the intra-tumor genomic clonal architecture present in the originating breast cancers was mostly preserved upon serial passaging in xenografts and in short-term cultured PDTCs...
September 22, 2016: Cell
https://www.readbyqxmd.com/read/27638965/the-prognostic-impact-and-optimal-timing-of-the-patient-health-questionnaire-depression-screen-on-4-year-mortality-among-hospitalized-patients-with-systolic-heart-failure
#20
Tatiana K Deveney, Bea Herbeck Belnap, Sati Mazumdar, Bruce L Rollman
OBJECTIVE: An American Heart Association (AHA) Science Advisory recommends patients with coronary heart disease undergo routine screening for depressive symptoms with the two-stage Patient Health Questionnaire (PHQ). However, little is known on the prognostic impact of a positive PHQ screen on heart failure (HF) mortality. METHODS: We screened hospitalized patients with systolic HF (left ventricle ejection fraction≤40%) for depression with the two-item Patient Health Questionnaire (PHQ-2) and administered the follow-up nine-item Patient Health Questionnaire (PHQ-9) both immediately following the PHQ-2 and by telephone 1 month after discharge...
September 2016: General Hospital Psychiatry
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