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https://www.readbyqxmd.com/read/29328521/the-central-vein-sign-differentiates-ms-from-cns-inflammatory-vasculopathies
#1
Pietro Maggi, Martina Absinta, Matteo Grammatico, Luisa Vuolo, Giacomo Emmi, Giovanna Carlucci, Gregorio Spagni, Alessandro Barilaro, Anna Maria Repice, Lorenzo Emmi, Domenico Prisco, Vittorio Martinelli, Roberta Scotti, Niloufar Sadeghi, Gaetano Perrotta, Pascal Sati, Bernard Dachy, Daniel S Reich, Massimo Filippi, Luca Massacesi
OBJECTIVES: In multiple sclerosis (MS), MRI is a sensitive tool for detecting white matter lesions, but its diagnostic specificity is still suboptimal; ambiguous cases are frequent in clinical practice. Detection of perivenular lesions in the brain (the "central vein sign") improves the pathological specificity of MS diagnosis, but comprehensive evaluation of this MRI biomarker in MS-mimicking inflammatory and/or autoimmune diseases, such as CNS inflammatory vasculopathies, is missing...
January 12, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29305345/corneal-endothelial-alterations-in-alcohol-dependence-syndrome
#2
Alok Sati, Parthasarathi Moulick, Sandeep Shankar, Kaushik Chatterjee, Arun Kumar Dwivedi, Jayesh Vazirani
BACKGROUND/AIMS: To evaluate the corneal endothelial changes in patients with alcohol dependence syndrome (ADS). METHODS: A total of 322 corneas of 322 subjects were studied, and two groups were formed. The first, the ADS group, included 161 corneas of 161 patients and the second, the age-matched control group, was composed of 161 corneas of 161 healthy subjects. Both the groups were examined by specular microscope and the endothelial parameters were compared. The endothelial parameters were also compared before and after the abstinence of alcohol in the former group...
January 5, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29304755/computational-approach-to-discriminate-human-and-mouse-sequences-in-patient-derived-tumour-xenografts
#3
Maurizio Callari, Ankita Sati Batra, Rajbir Nath Batra, Stephen-John Sammut, Wendy Greenwood, Harry Clifford, Colin Hercus, Suet-Feung Chin, Alejandra Bruna, Oscar M Rueda, Carlos Caldas
BACKGROUND: Patient-Derived Tumour Xenografts (PDTXs) have emerged as the pre-clinical models that best represent clinical tumour diversity and intra-tumour heterogeneity. The molecular characterization of PDTXs using High-Throughput Sequencing (HTS) is essential; however, the presence of mouse stroma is challenging for HTS data analysis. Indeed, the high homology between the two genomes results in a proportion of mouse reads being mapped as human. RESULTS: In this study we generated Whole Exome Sequencing (WES), Reduced Representation Bisulfite Sequencing (RRBS) and RNA sequencing (RNA-seq) data from samples with known mixtures of mouse and human DNA or RNA and from a cohort of human breast cancers and their derived PDTXs...
January 5, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29284868/comparison-of-three-different-concentrations-0-2-0-5-and-0-75-epidural-ropivacaine-for-postoperative-analgesia-in-lower-limb-orthopedic-surgery
#4
Amitesh Pathak, Neeraj Yadav, Sati Nath Mohanty, Ekta Ratnani, Om Prakash Sanjeev
Introduction: Ropivacaine has been studied previously and holds promise as an agent that offers a safe, efficacious, and better recovery profile than other conventional agents such as bupivacaine. The aim of the present study was to compare the safety and efficacy of equal volume of different concentration of ropivacaine for epidural analgesia in patients undergoing major lower limb orthopedic surgery. Subjects and Methods: One hundred and fifty adult patients were randomized into three groups to receive single dose of equal volume of ropivacaine through epidural route in concentrations of 0...
October 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29277909/milk-adulteration-with-acidified-rennet-whey-a-limitation-for-the-caseinomacropeptide-detection-by-high-performance-liquid-chromatography
#5
Érika de Pádua Alves, Anna Laura D'Amico de Alcântara, Anselmo José Klaechim Guimarães, Elsa Helena Walter de Santana, Bruno Garcia Botaro, Rafael Fagnani
BACKGROUND: High-performance liquid chromatography (HPLC) is widely employed to determine the caseinomacropeptide (CMP) index and detect milk tampering with rennet whey. Prior to HPLC analysis, CMP is subject to a trichloracetic acid (TCA) isolation causing further soluble proteins in the sample to precipitate. On this basis, we wanted to estimate if rennet whey acidification could adversely affect the HPLC sensitivity to detect this peptide. RESULTS: As hypothesized, the CMP index from milk added with acidified rennet whey was, on average, half as less as that quantified from milk added with rennet whey...
December 25, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29197690/the-first-clinical-practice-experiences-of-psychiatric-nursing-students-a-phenomenological-study
#6
Satı Demir, Feride Ercan
OBJECTIVE: The purpose of this study was to evaluate student nurses clinical experiences during their first clinical contacts with psychiatric patients by using a qualitative phenomenological approach. DESIGN: A phenomenological approach was used. Face-to-face interviews were conducted to collect data focusing on the reality of student nurses' experience. SETTINGS: This study was conducted at a university in the capital city of Turkey. PARTICIPANTS: The participants were undergraduate nursing students...
November 21, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/29158147/joint-analysis-of-cognitive-and-circadian-variation-in-schizophrenia-and-bipolar-i-disorder
#7
Pramod Thomas, Fanyin He, Sati Mazumdar, Joel Wood, Triptish Bhatia, Ruben C Gur, Raquel E Gur, Daniel Buysse, Vishwajit L Nimgaonkar, Smita N Deshpande
BACKGROUND: Impairment in cognitive variables and alterations in circadian function have been documented among patients with schizophrenia (SZ) and bipolar I disorder (BP1), but it is not known whether joint analysis of these variables can define clinically relevant sub-groups in either disorder. OBJECTIVES: To evaluate the pattern and relationship of cognitive and circadian function in SZ and BP1 patients with respect to diagnosis and indices of clinical severity...
November 7, 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29150736/effect-of-erythrocyte-sperm-separation-medium-on-nuclear-acrosomal-and-membrane-maturity-parameters-in-human-sperm
#8
Bikem Soygur, Soner Celik, Ciler Celik-Ozenci, Leyla Sati
PURPOSE: The purpose of this study is to investigate whether erythrocyte-sperm separation medium (ESSM) has effects on human sperm motility, morphology, viability, membrane maturity, acrosome integrity, and nuclear attributes before and after cryopreservation. METHODS: Semen samples from normozoospermic (n = 36) and oligozoospermic (n = 9) patients were analyzed. Samples from the same patient were divided into three aliquots: group 1 and group 2 were resuspended in sperm washing media and ESSM, respectively...
November 18, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29142547/an-evaluation-of-thyroid-autoimmunity-in-patients-with-beta-thalassemia-minor-a-case-control-study
#9
Ali Ramazan Benli, Sati Sena Yildiz, Mehmet Ali Cikrikcioglu
Objective: The tendency to autoimmune diseases has been reported to be increased in beta thalassemia minor (BTM). The aim of this study was to evaluate whether thyroid autoimmunity is higher in BTM. Methods: Patients with BTM (n=86) and a healthy control group (n=93) were included in this cross-sectional case-control study. The two groups were compared in terms of anti-thyroglobulin (anti-TG) and anti-thyroid peroxidase (anti-TPO) and thyroid hormones. Results: In the BTM group, thyroid hormones and serum anti-TG and anti-TPO antibody levels were not statistically different from those of the control group...
September 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29137507/nationwide-mortality-studies-to-quantify-causes-of-death-relevant-lessons-from-india-s-million-death-study
#10
Mireille Gomes, Rehana Begum, Prabha Sati, Rajesh Dikshit, Prakash C Gupta, Rajesh Kumar, Jay Sheth, Asad Habib, Prabhat Jha
Progress toward the United Nations 2030 Sustainable Development Goals requires improved information on mortality and causes of death. However, causes of many of the fifty million annual deaths in low- and middle-income countries remain unknown, as most of the deaths occur at home without medical attention. In 2001 India began the Million Death Study in 1.3 million nationally representative households. Nonmedical staff conduct verbal autopsies, which are structured interviews including a half-page narrative in local language of the family's story of the symptoms and events leading to death...
November 2017: Health Affairs
https://www.readbyqxmd.com/read/29133417/human-resistin-protects-against-endotoxic-shock-by-blocking-lps-tlr4-interaction
#11
Jessica C Jang, Jiang Li, Luca Gambini, Hashini M Batugedara, Sandeep Sati, Mitchell A Lazar, Li Fan, Maurizio Pellecchia, Meera G Nair
Helminths trigger multiple immunomodulatory pathways that can protect from sepsis. Human resistin (hRetn) is an immune cell-derived protein that is highly elevated in helminth infection and sepsis. However, the function of hRetn in sepsis, or whether hRetn influences helminth protection against sepsis, is unknown. Employing hRetn-expressing transgenic mice (hRETNTg+) and recombinant hRetn, we identify a therapeutic function for hRetn in lipopolysaccharide (LPS)-induced septic shock. hRetn promoted helminth-induced immunomodulation, with increased survival of Nippostrongylus brasiliensis (Nb)-infected hRETNTg+ mice after a fatal LPS dose compared with naive mice or Nb-infected hRETNTg- mice...
November 28, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29118592/a-review-of-the-genus-lordiphosa-basden-in-india-with-descriptions-of-four-new-species-from-the-himalayan-region-diptera-drosophilidae
#12
Rajendra S Fartyal, Pradeep C Sati, Sushmika Pradhan, Mukul C Kandpal, Masanori J Toda, Rabindra N Chatterjee, Birendra K Singh, Asha Bhardwai
All Indian species of the genus Lordiphosa Basden are reviewed, with descriptions of four new species, L. curva Fartyal & Toda, sp. n. of the denticeps species group and L. ayarpathaensis Kandpal & Singh, sp. n., L. makaibarensis Pradhan & Chatterjee, sp. n. and L. srinagarensis Sati & Fartyal, sp. n. of the nigricolor species group. Two of the new species, L. ayarpathaensis and L. makaibarensis, were found visiting flowers of Hedychium spicatum and Datura suaveolens, respectively. This is the first record of flower visitation in Lordiphosa flies...
2017: ZooKeys
https://www.readbyqxmd.com/read/29051509/the-transcriptional-regulator-ntrc-controls-glucose-6-phosphate-dehydrogenase-expression-and-polyhydroxybutyrate-synthesis-through-nadph-availability-in-herbaspirillum-seropedicae
#13
Euclides Nenga Manuel Sacomboio, Edson Yu Sin Kim, Henrique Leonardo Ruchaud Correa, Paloma Bonato, Fabio de Oliveira Pedrosa, Emanuel Maltempi de Souza, Leda Satie Chubatsu, Marcelo Müller-Santos
The NTR system is the major regulator of nitrogen metabolism in Bacteria. Despite its broad and well-known role in the assimilation, biosynthesis and recycling of nitrogenous molecules, little is known about its role in carbon metabolism. In this work, we present a new facet of the NTR system in the control of NADPH concentration and the biosynthesis of molecules dependent on reduced coenzyme in Herbaspirillum seropedicae SmR1. We demonstrated that a ntrC mutant strain accumulated high levels of polyhydroxybutyrate (PHB), reaching levels up to 2-fold higher than the parental strain...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29034204/studies-on-analgesic-anti-inflammatory-activities-of-stem-and-roots-of-inula-cuspidata-c-b-clarke
#14
Sarvesh Kumar Paliwal, Bhawana Sati, Samriti Faujdar, Swapnil Sharma
The present study was carried out to evaluate analgesic and anti-inflammatory activities in Inula cuspidata stem and root extracts along with heavy metals estimation in stem and root powder. Stem and roots were extracted with chloroform (ICSCE, ICRCE) and methanol (ICSME, ICRME). Acute oral toxicity of all extracts was determined by OECD guidelines 425. Analgesic activity was investigated by using hot plate and acetic acid induced writhing models. Anti-inflammatory activity (acute) of all extracts was evaluated by carrageenan induced paw edema model...
October 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29032809/evaluation-of-polycyclic-aromatic-hydrocarbons-bioavailability-on-santos-bay-brazil-through-levels-of-biliary-metabolites
#15
Ana Cecília Rizzatti de Albergaria-Barbosa, Denis Albuquerque Moreira da Silva, Arthur José da Silva Rocha, Satie Taniguchi, Vinicius Faria Patire, June Ferraz Dias, Wellington Silva Fernandez, Marcia Caruso Bícego
This study evaluated the PAH bioavailability from Santos Bay (Brazil) in 4 species of fish, using PAH biliary metabolites. The collection was done monthly, between July and December, in three different regions of Santos Bay. The metabolites were analyzed through a high performance liquid chromatograph with fluorescence detectors. Total metabolites concentrations ranged from 65.5 to 589μgg(-1) of bile, evidencing PAH bioavailability on Santos Bay. Levels of phenanthrene and benzo[a]pyrene metabolites were in the classification range of areas moderate contaminated...
October 10, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28971799/human-and-nonhuman-primate-meninges-harbor-lymphatic-vessels-that-can-be-visualized-noninvasively-by-mri
#16
Martina Absinta, Seung-Kwon Ha, Govind Nair, Pascal Sati, Nicholas J Luciano, Maryknoll Palisoc, Antoine Louveau, Kareem A Zaghloul, Stefania Pittaluga, Jonathan Kipnis, Daniel S Reich
Here, we report the existence of meningeal lymphatic vessels in human and nonhuman primates (common marmoset monkeys) and the feasibility of noninvasively imaging and mapping them in vivo with high-resolution, clinical MRI. On T2-FLAIR and T1-weighted black-blood imaging, lymphatic vessels enhance with gadobutrol, a gadolinium-based contrast agent with high propensity to extravasate across a permeable capillary endothelial barrier, but not with gadofosveset, a blood-pool contrast agent. The topography of these vessels, running alongside dural venous sinuses, recapitulates the meningeal lymphatic system of rodents...
October 3, 2017: ELife
https://www.readbyqxmd.com/read/28953235/comparative-evaluation-of-polyphenol-contents-and-antioxidant-activities-between-ethanol-extracts-of-vitex-negundo-and-vitex-trifolia-l-leaves-by-different-methods
#17
Sarla Saklani, Abhay Prakash Mishra, Harish Chandra, Maria Stefanova Atanassova, Milan Stankovic, Bhawana Sati, Mohammad Ali Shariati, Manisha Nigam, Mohammad Usman Khan, Sergey Plygun, Hicham Elmsellem, Hafiz Ansar Rasul Suleria
The in vitro antioxidant potential assay between ethanolic extracts of two species from the genus Vitex (Vitex negundo L. and Vitex trifolia L.) belonging to the Lamiaceae family were evaluated. The antioxidant properties of different extracts prepared from both plant species were evaluated by different methods. DPPH scavenging, nitric oxide scavenging, and β-carotene-linoleic acid and ferrous ion chelation methods were applied. The antioxidant activities of these two species were compared to standard antioxidants such as butylated hydroxytoluene (BHT), ascorbic acid, and Ethylene diamine tetra acetic acid (EDTA)...
September 27, 2017: Plants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28941702/young-bamboo-culm-potential-food-as-source-of-fiber-and-starch
#18
Mária Herminia Ferrari Felisberto, Patricia Satie Endo Miyake, Antonio Ludovico Beraldo, Maria Teresa Pedrosa Silva Clerici
With the objective of widening the use of bamboo in the food industry, the present work aimed to produce and characterize the young bamboo culm flours from varieties Dendrocalamus asper, Bambusa tuldoides and Bambusa vulgaris as potential sources of fiber and starch. The young culms were collected, cut in three sections (bottom, middle, top), processed into flour, and they were physically, chemically and technologically analyzed. The data were obtained in triplicate and evaluated by means of average differences, using analysis of variance (ANOVA) and Scott-Knott test (p<0...
November 2017: Food Research International
https://www.readbyqxmd.com/read/28927247/relationship-between-sleeping-difficulties-and-airway-symptoms-severity-with-the-health-related-quality-of-life-in-patients-with-gerd
#19
Claudio Andaloro, Mario Sati, Calogero Grillo, Caterina M Grillo, Ignazio LA Mantia
BACKGROUND: Gastroesophageal reflux disease (GERD) is a chronic disease highly associated with several pulmonary disease and sleep disorders leading to a negative impact on the quality of life. Aim of this study was to investigate the correlation between these disorders and the health-related quality of life. METHODS: Patients were recruited from the Department of Medical Sciences, Surgical and Advanced Technologies, GF Ingrassia, University of Catania, from October 2015 to May 2016...
December 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28912009/an-inflammation-based-prognostic-score-the-c-reactive-protein-albumin-ratio-predicts-the-morbidity-and-mortality-of-patients-on-parenteral-nutrition
#20
J Llop-Talaveron, M B Badia-Tahull, E Leiva-Badosa
BACKGROUND: There is no "gold standard" score for predicting poor-nutrition-related outcomes. The objective of this study was to identify the optimal predictive score, based on inflammatory parameters, for the clinical outcomes of parenteral nutrition (PN). MATERIAL AND METHODS: This was a 4-year retrospective observational study of 460 patients treated with PN. C-reactive protein (CRP), prealbumin, albumin, CRP/prealbumin and CRP/albumin were studied as potential prognostic scores at the beginning of PN for clinical outcomes during PN...
August 21, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
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