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Natriuretic peptide

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https://www.readbyqxmd.com/read/29148905/serum-glucose-potassium-ratio-as-a-clinical-risk-factor-for-aneurysmal-subarachnoid-hemorrhage
#1
Yu Fujiki, Fumihiro Matano, Takayuki Mizunari, Yasuo Murai, Kojiro Tateyama, Kenta Koketsu, Asami Kubota, Shiro Kobayashi, Hiroyuki Yokota, Akio Morita
OBJECTIVE Aneurysmal subarachnoid hemorrhage (SAH) can result in poor outcomes, and biomarkers for predicting poor prognosis have not yet been established. The aim of this study was to clarify the significance of the serum glucose/potassium ratio for predicting the prognosis of aneurysmal SAH. METHODS The authors retrospectively reviewed the records of 565 patients with aneurysmal SAH between 2006 and 2016. The patient group comprised 208 men and 357 women (mean age 61.5 years, range 10-95 years). A statistical analysis was conducted of the clinical and laboratory risk factors of poor outcome, including the serum glucose/potassium ratio...
November 17, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29147972/plasma-osteopontin-levels-in-patients-with-dilated-and-hypertrophic-cardiomyopathy
#2
J Podzimkova, T Palecek, P Kuchynka, J Marek, B A Danek, M Jachymova, M Kalousova, T Zima, A Linhart
BACKGROUND: Osteopontin (OPN) is an extracellular matrix glycoprotein that plays a role in a variety of cellular activities associated with inflammatory and fibrotic responses. Increased OPN levels in myocardium and plasma have been demonstrated in patients with dilated cardiomyopathy (DCM). However, nothing is known about OPN levels in patients with hypertrophic cardiomyopathy (HCM). Therefore, the aim of our study was to compare plasma OPN levels in patients with these two most common cardiomyopathies...
November 16, 2017: Herz
https://www.readbyqxmd.com/read/29147074/increased-levels-of-srage-in-diabetic-ckd-g5d-patients-a-potential-protective-mechanism-against-age-related-upregulation-of-fibroblast-growth-factor-23-and-inflammation
#3
Elena Dozio, Valentina Corradi, Elena Vianello, Elisa Scalzotto, Massimo de Cal, Massimiliano Marco Corsi Romanelli, Claudio Ronco
Advanced glycation end products (AGEs) may induce cardiac remodeling in kidney disease by promoting fibroblast growth factor 23 (FGF-23) expression. Since AGEs are increased in diabetes mellitus (DM), our first aim was to evaluate the existence of any potential association between AGEs, FGF-23, inflammation, and increased cardiovascular risk in DM patients on dialysis (CKD-G5D). Secondarily, we explored the potential role of the soluble receptor for AGEs (sRAGE) as a marker of heart failure. Levels of glycated albumin (GA), sRAGE, c-terminal FGF-23 (cFGF-23), brain natriuretic peptide (BNP), and inflammatory mediators were compared between DM and non-DM CKD-G5D patients...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/29145814/elevated-exhaled-acetone-concentration-in-stage-c-heart-failure-patients-with-diabetes-mellitus
#4
Tetsuro Yokokawa, Takamasa Sato, Satoshi Suzuki, Masayoshi Oikawa, Akiomi Yoshihisa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Kazuhiko Nakazato, Hitoshi Suzuki, Shu-Ichi Saitoh, Takafumi Ishida, Akito Shimouchi, Yasuchika Takeishi
BACKGROUND: Breath acetone is a noninvasive biomarker of heart failure; however, its significance in heart failure patients with diabetes mellitus has yet to be clarified. The objective of this study is to investigate whether exhaled acetone concentration is a noninvasive biomarker in heart failure patients with diabetes mellitus. METHODS: This study prospectively included 35 diabetic patients with stage C heart failure and 20 diabetic patients with or at risk of heart failure (stage A or B)...
November 16, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29144270/alkaline-phosphatase-in-infant-cardiopulmonary-bypass-kinetics-and-relationship-to-organ-injury-and-major-cardiovascular-events
#5
Jesse A Davidson, Tracy T Urban, Christine Baird, Suhong Tong, Alan Woodruff, Mark Twite, James Jaggers, Eric A F Simões, Paul Wischmeyer
OBJECTIVES: To determine the kinetics of alkaline phosphatase (AP) activity and concentration after infant cardiopulmonary bypass, including isoform-specific changes, and to measure the association between postoperative AP activity and major postoperative cardiovascular events, organ injury/dysfunction, and postoperative support requirements STUDY DESIGN: Prospective cohort study of 120 infants ≤120 days of age undergoing cardiopulmonary bypass. AP total and isoform-specific activity was assessed at 6 time points (preoperation, rewarming, 6, 24, 48, and 72 hours postoperation)...
November 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29143708/genome-wide-association-study-for-growth-traits-in-nelore-cattle
#6
A P N Terakado, R B Costa, G M F de Camargo, N Irano, T Bresolin, L Takada, C V D Carvalho, H N Oliveira, R Carvalheiro, F Baldi, L G de Albuquerque
The objective of this study was to investigate the association of single nucleotide polymorphisms (SNPs) with birth weight, weight gain from birth to weaning and from weaning to yearling, yearling height and cow weight in Nelore cattle. Data from 5064 animals participating in the DeltaGen and PAINT breeding programs were used. The animals were genotyped with a panel of 777 962 SNPs (Illumina BovineHD BeadChip) and 412 993 SNPs remained after quality control analysis of the genomic data. A genome-wide association study was performed using a single-step methodology...
November 16, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29143161/point-of-care-b-type-natriuretic-peptide-and-portable-echocardiography-for-assessment-of-patients-with-suspected-heart-failure-in-primary-care-rationale-and-design-of-the-three-part-handheld-bnp-program-and-results-of-the-training-study
#7
Caroline Morbach, Thomas Buck, Christian Rost, Sebastian Peter, Stephan Günther, Stefan Störk, Christiane Prettin, Raimund Erbel, Georg Ertl, Christiane E Angermann
BACKGROUND: Patients with suspected heart failure (HF) often present first to general practitioners (GPs). Timely and accurate HF diagnosis and reliable prognostic information have remained unmet goals in primary care, where patient evaluation often relies on clinical assessment only. The Handheld-BNP program investigates whether additional use of portable echocardiography (ECHO) and point-of-care determination of B-type natriuretic peptide (BNP) improves the accuracy of HF diagnosis and aids risk prediction in primary care...
November 15, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29142764/determining-nt-probnp-levels-with-diastolic-dysfunction-in-thalassemia-major-patients
#8
Mable Misha Singh, Ravindra Kumar, Satyendra Tewari, Sarita Agarwal
Beta thalassemia is an autosomal, recessive disorder, characterized by ineffective erythropoiesis. Chronic transfusions and inability of body to eliminate iron lead to an iron overload, thereby causing damage to heart. Natriuretic peptides (NPs) are produced within the heart, which are then released into the circulation in response to ventricular wall stress. We, therefore, aimed to study the relation between ventricular dysfunction and N-terminal pro-B-type natriuretic peptides (NT-proBNPs). We enrolled 105 patients with increased serum ferritin levels and echocardiography was performed...
December 2017: Journal of Pediatric Genetics
https://www.readbyqxmd.com/read/29141525/hyperacute-hemodynamic-effects-of-bipap-noninvasive-ventilation-in-patients-with-acute-heart-failure-and-left-ventricular-systolic-dysfunction-in-emergency-department
#9
Cinzia Moret Iurilli, Natale Daniele Brunetti, Paola Rita Di Corato, Giuseppe Salvemini, Matteo Di Biase, Marco Matteo Ciccone, Vito Procacci
BACKGROUND: Acute heart failure (AHF) is one of the leading causes of admission to emergency department (ED); severe hypoxemic AHF may be treated with noninvasive ventilation (NIV). Despite the demonstrated clinical efficacy of NIV in relieving symptoms of AHF, less is known about the hyperacute effects of bilevel positive airway pressure (BiPAP) ventilation on hemodynamics of patients admitted to ED for AHF. We therefore aimed to assess the effect of BiPAP ventilation on principal hemodynamic, respiratory, pulse oximetry, and microcirculation indexes in patients admitted to ED for AHF, needing NIV...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/29141241/mmp-9-and-its-regulators-timp-1-and-emmprin-in-patients-with-acute-st-elevation-myocardial-infarction-a-nordistemi-substudy
#10
Trine Baur Opstad, Ingebjørg Seljeflot, Ellen Bøhmer, Harald Arnesen, Sigrun Halvorsen
OBJECTIVES: The extracellular matrix is involved in wound repair after acute myocardial infarction (AMI). We investigated whether matrix metalloproteinase (MMP)-9, tissue inhibitor of metalloproteinases (TIMP)-1, and the MMP inducer (EMMPRIN) are associated with infarct size, left ventricular function, and clinical outcome in ST-elevation-MI (STEMI). METHODS: In 243 STEMI patients, circulating EMMPRIN, MMP-9, and TIMP-1 were analyzed 3 days and 3 months post-AMI...
November 16, 2017: Cardiology
https://www.readbyqxmd.com/read/29140804/exploration-of-predictive-biomarkers-for-sudden-unexplained-cardiac-death-in-nonelderly-people-a-case-control-study-with-biochemical-parameters-related-to-heart-failure
#11
Sakai Kentaro, Iwadate Kimiharu, Matsumoto Sari, Takasu Shojiro, Kanto Yuko
Sudden unexplained cardiac death (SUCD) can occasionally occur in nonelderly patients with epilepsy, psychiatric disorders, or no medical history. This study was conducted to aim to analyze whether values of the biomarkers for heart failure are associated with the SUCD. Serum concentrations of N-terminal probrain natriuretic peptide, high-sensitivity C-reactive protein (hs-CRP), and tumor necrosis factor α were analyzed in 57 nonelderly patients with SUCD who was diagnosed at medicolegal autopsy. The subjects were divided into 3 subgroups according to the medical history: (1) epilepsy, (2) psychiatric disorders, and (3) no specific medical history...
November 15, 2017: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/29140729/gene-expression-and-gene-associations-during-the-development-of-heart-failure-with-preserved-ejection-fraction-in-the-dahl-salt-sensitive-model-of-hypertension
#12
Jeffrey Yim, Hyokeun Cho, Simon W Rabkin
Gene expression and associations were examined in a model of heart failure with preserved ejection fraction (HFpEF), a condition with minimal effective treatment. Genes with at least two studies showing significant changes in Dahl rat with heart failure were examined by meta-analysis. Significantly increased in expression were iNOS, p47phox, ADM, ANP, OPN, ACE, MCP-1, GP91PHOX, ICAM-1, TGF-β1, CTGF, ET-1, p22phox, ETB, BNP, ETA, MMP13, Col1a1, MMP2, TIMP1, Col3a1, Il-1β, β-MHC, ECE1, MMP14, AGT, and MMP9...
November 15, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29138270/low-and-high-renin-heart-failure-phenotypes-with-clinical-implications
#13
Noemi Pavo, Georg Goliasch, Raphael Wurm, Johannes Novak, Guido Strunk, Mariann Gyöngyösi, Marko Poglitsch, Marcus D Säemann, Martin Hülsmann
BACKGROUND: Blockade of the renin-angiotensin system (RAS) represents a main strategy in the therapy of heart failure with reduced ejection fraction (HFrEF), but the role of active renin concentration (ARC) for guiding therapy in the presence of an RAS blockade remains to be established. This study assessed angiotensin profiles of HFrEF patients with distinct RAS activations as reflected by ARC. METHODS: Two cohorts of stable chronic HFrEF patients on optimal medical treatment (OMT) were enrolled...
November 14, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29138023/oleanonic-acid-ameliorates-pressure-overload-induced-cardiac-hypertrophy-in-rats-the-role-of-pkc%C3%AE-nf-%C3%AE%C2%BAb-pathway
#14
Hui Gao, Hui Liu, Tiexin Tang, Xiaofei Huang, Dongxiu Wang, Yan Li, Pan Huang, Yingfu Peng
It has been reported that inflammation is closely related with cardiac hypertrophy. Some inflammatory cytokines such as tumor necrosis factor-α, interleukin-1β, and interleukin-6 directly induce cardiac hypertrophy, which is associated with the activation of nuclear factorkappa B (NF-κB). Thus, NF-κB is an attractive target for cardiac hypertrophy. In the present study, oleanonic acid inhibited the elevation of transcriptional activity of NF-κB and reduced the mRNA expressions of hypertrophic genes such as atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP) in a concentration-dependent manner in phenylephrine (PE)-treated cardiomyocytes...
November 11, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29137478/effects-of-increased-myocardial-tissue-concentration-of-myristic-palmitic-and-palmitoleic-acids-on-the-course-of-cardiac-atrophy-of-the-failing-heart-unloaded-by-heterotopic-transplantation
#15
M Pokorný, I Mrázová, J Malý, J Pirk, I Netuka, Z Vaňourková, Š DoleŽelová, L Červenková, H Maxová, V Melenovský, J Šochman, J Sadowski, L Červenka
The present experiments were performed to evaluate if increased heart tissue concentration of fatty acids, specifically myristic, palmitic and palmitoleic acids that are believed to promote physiological heart growth, can attenuate the progression of unloading-induced cardiac atrophy in rats with healthy and failing hearts. Heterotopic abdominal heart transplantation (HT(x)) was used as a model for heart unloading. Cardiac atrophy was assessed from the ratio of the native- to-transplanted heart weight (HW)...
November 10, 2017: Physiological Research
https://www.readbyqxmd.com/read/29136192/assessing-the-hydration-status-of-children-with-chronic-kidney-disease-and-on-dialysis-a-comparison-of-techniques
#16
Caroline S Y Eng, Devina Bhowruth, Mark Mayes, Lynsey Stronach, Michelle Blaauw, Amy Barber, Lesley Rees, Rukshana C Shroff
Background: Fluid balance is pivotal in the management of children with chronic kidney disease (CKD) and on dialysis. Although many techniques are available to assess fluid status, there are only a few studies for children, of which none have been comparable against cardiovascular outcome measures. Methods: We performed a longitudinal study in 30 children with CKD5-5D and 13 age-matched healthy controls (71 measurements) to determine a correlation between optimal weight by bioimpedance spectroscopy (Wt-BIS) and clinical assessment (Wt-CA)...
November 9, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29133364/day-by-day-variability-of-home-blood-pressure-and-incident-cardiovascular-disease-in-clinical-practice-the-j-hop-study-japan-morning-surge-home-blood-pressure
#17
Satoshi Hoshide, Yuichiro Yano, Hiroyuki Mizuno, Hiroshi Kanegae, Kazuomi Kario
We assessed the relationship between day-by-day home blood pressure (BP) variability and incident cardiovascular disease (CVD) in clinical practice. J-HOP study (Japan Morning Surge-Home Blood Pressure) participants underwent home BP monitoring in the morning and evening for a 14-day period, and their BP levels and BP variability independent of the mean (VIM) were assessed. Incident CVD events included coronary heart disease and stroke. Cox models were fitted to assess the home BP variability-CVD risk association...
November 13, 2017: Hypertension
https://www.readbyqxmd.com/read/29133328/associations-of-time-of-day-with-cardiovascular-disease-risk-factors-measured-in-older-men-results-from-the-british-regional-heart-study
#18
Claudio Sartini, Peter H Whincup, S Goya Wannamethee, Barbara J Jefferis, Lucy Lennon, Gordon DO Lowe, Paul Welsh, Naveed Sattar, Richard W Morris
OBJECTIVE: We estimated associations of time of day with cardiovascular disease (CVD) risk factors measured in older men. METHODS: CVD risk factors (markers of inflammation and haemostasis, and cardiac markers) were measured on one occasion between 08:00 and 19:00 hours in 4252 men aged 60-79 years from the British Regional Heart Study. Linear models were used to estimate associations between time of day and risk factors. When an association was found, we examined whether the relationship between risk factors and cardiovascular mortality was affected by the adjustment for time of day using survival analyses...
November 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/29132262/diastolic-dysfunction-is-common-in-survivors-of-pediatric-differentiated-thyroid-carcinoma
#19
Mariëlle Sanne Klein Hesselink, Gianni Bocca, Yoran M Hummel, Adrienne H Brouwers, Johannes G M Burgerhof, Eveline W C M van Dam, Jourik A Gietema, Bas Havekes, Marry M van den Heuvel-Eibrink, Eleonora P M Corssmit, Leontien Kremer, Romana Netea-Maier, Helena J H van der Pal, Robin Peeters, John Th M Plukker, Cécile M Ronckers, Hanneke M van Santen, Peter van der Meer, Thera P Links, Wim J E Tissing
INTRODUCTION: Whether pediatric patients with differentiated thyroid carcinoma (DTC) are at risk of developing treatment-related adverse effects on cardiac function is unknown. We therefore studied in long-term survivors of pediatric DTC the prevalence of cardiac dysfunction and atrial fibrillation (AF) in relation to treatment variables, and the association between cardiac dysfunction and plasma biomarkers. PATIENTS AND METHODS: In this nationwide prospective multicenter study, cardiac assessments were performed in 66 adult survivors of pediatric DTC (age at diagnosis ≤18 years and follow-up ≥5 years after diagnosis) treated in The Netherlands between 1970 and 2009...
November 13, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29131295/the-intracardiac-concentrations-of-the-n-terminal-pro-b-type-natriuretic-peptide-nt-probnp-and-the-determinants-of-its-secretion-in-patients-with-atrial-fibrillation
#20
Witold Streb, Katarzyna Mitręga, Magdalena Szymała, Aleksandra Woźniak, Tomasz Podolecki, Zbigniew Kalarus
BACKGROUND: N-terminal-pro Brain Natriuretic Peptide (NT-proBNP) is elevated not only in heart failure (HF) but also in atrial fibrillation (AF). The role and secretion pattern of NT-proBNP in AF is still undetermined. AIM: The study aimed to assess NT-proBNP concentrations in patients with and without preserved left ventricular ejection fraction (LV-EF) depending on the type of AF. It was also intended to define the main source of NT-proBNP production within the heart...
November 13, 2017: Kardiologia Polska
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