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Secondary hyperparathyrodism

E Târcoveanu, D Niculescu, Elena Cotea, R Moldovanu, A Vasilescu, Felicia Crumpei, E Zbranca, Fl Zugun, V Rusu, D Ferariu
UNLABELLED: Multiple endocrine neoplasias are syndromes characterized by the involvement of at least two endocrine glands. Parathyroid gland involvement is usually noted in Multiple Endocrine Neoplasia (MEN) type I and type II. Parathyroid glands tumor associated with endocrine pancreatic tumor, as well as pituitary tumors is the typical pattern of MEN I. The parathyroid gland is the most frequent abnormality in MEN I. CASES REPORTS: We presented five cases with MEN I and parathyroid glands involvement...
April 2009: Revista Medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti Din Iaş̧i
Tetsuhiko Sato
Secondary hyperparathyrodism and uremic symptoms have long been discussed for more than 2 decades. Its relevance may indicate PTH-receptor interaction in ESRD. Two human PTH receptors (PTH1R, PTH2R) are now identified and distributed in extrarenal and extraskeletal organs, such as nerve system, cardiovascular system and lung. These organ-related symptoms and complications may be related to elevated PTH levels in ESRD. PTH should be well-controlled within optimized levels to prevent irreversible serious complications...
December 2002: Clinical Calcium
I Sotorník, P Bubenícek, M Adamec, L Karasová, C Povýsil, J Skibová
BACKGROUND: Parathyroids dysfunction is a key disorder in the spectrum of renal osteopathy, occurring after renal transplantation and, occasionally, after parathyroidectomy. In our subjects, dysfunction is understood as plus or minus activity. METHODS AND RESULTS: Parathyroidectomy as the primary procedure was performed in 179 patients for all types of hyperparathyrodism. In 70% of cases the secondary hyperparathyroidism was treated, believed to be the most severe condition...
2003: Casopís Lékar̆ů C̆eských
Fong-Fu Chou, Chiang-Hsuan Lee, Chien-Te Lee, Fu-Jen Huang, Kuan-Long Hsu
BACKGROUND: The changes in spermatogenesis after parathyroidectomy in patients with symptomatic secondary hyperparathyroidism have not been reported before. STUDY DESIGN: Nineteen men with symptomatic secondary hyperparathyrodism were enrolled in our study. Their ages ranged from 29 to 50 years and duration of dialysis from 72 to 168 months. Before operation, serum levels of calcium, phosphorus, alkaline phosphatase, intact parathyroid hormone, prolactin, luteinizing hormone, follicle-stimulating hormone, and testosterone were checked routinely in association with semen analysis...
June 2003: Journal of the American College of Surgeons
I Martínez, R Saracho, J Ocharán, R I Muñoz, J Montenegro
Secondary hyperparathyrodism (SH) is an early manifestation of chronic renal failure (CRF), which has serious complications. Moreover, treating SH is not a risk-free process. Once in its advanced state, it is extremely difficult to reverse and therefore it is critical an early intervention and prevention. An excess of phosphorus and a deficit of calcium and calcitriol are key factors in the evolution of SH. Despite the fact that plasma phosphorus levels remain normal until an extremely advanced stage of CRF, and even apparent hyperphosphatemia in mild CRF, it has been shown that restricting dietary levels of protein and phosphorus impedes the progression of SH...
2003: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
GianCarlo Abbona, Mauro Papotti, Guido Gasparri, Gianni Bussolati
The histological pattern and the cell proliferative activity (as detected by Ki-67 immunostaining) of a series of 50 parathyroid hyperplasias (PTHs) secondary to renal failure were studied to assess their value in predicting recurrence of hyperparathyrodism (HPT). On account of their clinical evolution, these cases were divided into two groups, recurrent HPT (23 cases) and nonrecurrent HPT (27 cases). A nodular growth pattern (as opposed to diffuse) was the prevalent one and was observed in 20 (74%) cases of now recurrent HPT and in 22 (95...
1996: Endocrine Pathology
D Pacheco, J Menárguez, E Cristobal, B Arribas, J A Alcazar, R Carrión, J R Polo
INTRODUCTION: The role of vitamin D receptor (VDR) gene polymorphism in the pathogenesis of hyperparathyrodism is not clear yet. The aim of this study was to examine the role of BsmI VDR gene polymorphism in patients with primary hyperparathyrodism (PHP) secondary to adenomas. MATERIAL AND METHODS: Fifty-two postmenopausal women with PHP, mean age 64.5 years, were compared with a normal age-matched female population (n = 81). RESULTS: Distribution of BsmI polymorphism in PHP group was: Bb 54% (28/52); BB 21% (11/52); bb 25% (13/52)...
July 2000: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
F F Chou, C H Lee, J B Chen
HYPOTHESES: There are factors that affect patients with general weakness owing to secondary hyperparathyroidism and as reported by results noted after parathyroidectomy and autotransplantation. DESIGN: Case series and consecutive samples. SETTING: Tertiary care center. PATIENTS: From July 1996 to June 1998, 56 patients with secondary hyperparathyroidism underwent total parathyroidectomy and autotransplantation. Their ages were 45 +/- 13 years (mean +/- SD) and preoperative duration of dialysis was 75 +/- 37 months...
October 1999: Archives of Surgery
G Turner, R C Brown, A Silver, G Seymour, J S Woodhead
Glomerular filtration rate (GFR) is frequently reduced in elderly people. However, the effect of this on mineral metabolism in this population has received little attention. GFR, serum intact parathyroid hormone (PTH) and vitamin D metabolites were measured in 37 patients admitted to hospital for various reasons. In 20 patients with GFR greater than 50 mL/min, an elevated serum intact PTH concentration (greater than 5.4 pmol/L) was found in two, while in 17 patients with GFR less than 50 mL/min PTH was elevated in 13...
July 1991: Annals of Clinical Biochemistry
W Koall, E Mampel, W Schneider, G Ditscherlein
In comparison with literary data is reported on 3 young men with a Goodpasture syndrome. Immunohistologically in all cases a glomerulonephritis of the type of basal membrane antibodies was proved, in one patient also still 14 months after having reached the terminal stage of the renal insufficeincy. In every case the disease led to the dialytic treatment without the necessity of nephrectomies for commanding haemmorrhages of the lungs. The longest survival time was 3 years. -- In 1 patient within metastatic calcifications a pronounced nephrocalcinosis developed...
July 1, 1977: Zeitschrift Für die Gesamte Innere Medizin und Ihre Grenzgebiete
H Jüppner, A A Bialasiewicz, R D Hesch
Autoantibodies which block the binding of parathyroid hormone to membrane receptors for the hormone were detected in the sera (especially in the IgG fraction) of 49 out of 50 uraemic patients with secondary hyperparathyroidism (patients with high levels of C-regional parathyroid hormone). These antibodies are species-specific. Their presence in the serum in unaffected by dialysis. Inhibition of binding appears to be related to the rise in C-regional parathyroid-hormone levels and the duration of uraemia. The production of cyclic adenosine monophosphate by parathyroid-hormone-stimulated adenyl cyclase was reduced by the blocking antibodies...
December 9, 1978: Lancet
C B Lamers, P G Froeling
In order to investigate the suggestion that hyperparathyroidism in patients with familial MEA I has a mild and nonprogressive clinical course, we have compared clinical, biochemical, roentgenologic and histologic features of 29 patients with hyperparathyrodism originating from six families with the MEA I syndrome with those of 28 unselected patients with isolated nonfamilial hyperparathyroidism. The patients from the families with MEA I were significantly younger, had lower serum calcium and inorganic phosphate concentrations and a lower incidence of elevated alkaline phosphatase levels...
March 1979: American Journal of Medicine
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