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https://www.readbyqxmd.com/read/29340945/electromagnetic-induction-sensor-for-dynamic-testing-of-coagulation-process
#1
Zhe Wang, Yuanhua Yu, Zhanjiang Yu, Qimeng Chen
With the increasing demand for coagulation POCT for patients in the surgery department or the ICU, rapid coagulation testing techniques and methods have drawn widespread attention from scholars and businessmen. This paper proposes the use of electromagnetic induction sensor probe for detection of dynamic process causing changes in the blood viscosity and density before and after coagulation based on the damped vibration principle, in order to evaluate the coagulation status. Utilizing the dynamic principle, the differential equation of vibration system comprising elastic support and electromagnetic induction device is established through sensor dynamic modeling...
January 16, 2018: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/29339078/analytical-and-pre-analytical-performance-characteristics-of-a-novel-cartridge-type-blood-gas-analyzer-for-point-of-care-and-laboratory-testing
#2
Matthijs Oyaert, Tom Van Maerken, Silke Bridts, Silvi Van Loon, Heleen Laverge, Veronique Stove
BACKGROUND: Point-of-care blood gas test results may benefit therapeutic decision making by their immediate impact on patient care. We evaluated the (pre-)analytical performance of a novel cartridge-type blood gas analyzer, the GEM Premier 5000 (Werfen), for the determination of pH, partial carbon dioxide pressure (pCO2), partial oxygen pressure (pO2), sodium (Na+), potassium (K+), chloride (Cl-), ionized calcium (iCa2+), glucose, lactate, and total hemoglobin (tHb). METHODS: Total imprecision was estimated according to the CLSI EP5-A2 protocol...
January 12, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29333106/which-point-of-care-tests-would-be-most-beneficial-to-add-to-clinical-practice-findings-from-a-survey-of-3-family-medicine-clinics-in-the-united-states
#3
Victoria Hardy, William Alto, Gina A Keppel, Laura-Mae Baldwin, Matthew Thompson
Background: Point-of-care tests (POCTs) are increasingly used in family medicine to facilitate screening, diagnosis, monitoring, treatment, and referral decisions for a variety of conditions. Point-of-care tests that clinicians believe might be beneficial to add to clinical practice and the conditions for which they would be most useful in family medicine remain poorly understood in the United States. Methods: Forty-two clinicians at 3 family medicine residency clinics completed a brief survey asking which POCTs they believed would be beneficial to add to their clinical practice and the conditions POCTs would be most useful for...
December 2017: Point of Care
https://www.readbyqxmd.com/read/29329274/current-technologies-of-electrochemical-immunosensors-perspective-on-signal-amplification
#4
REVIEW
Il-Hoon Cho, Jongsung Lee, Jiyeon Kim, Min-Soo Kang, Jean Kyung Paik, Seockmo Ku, Hyun-Mo Cho, Joseph Irudayaraj, Dong-Hyung Kim
An electrochemical immunosensor employs antibodies as capture and detection means to produce electrical charges for the quantitative analysis of target molecules. This sensor type can be utilized as a miniaturized device for the detection of point-of-care testing (POCT). Achieving high-performance analysis regarding sensitivity has been one of the key issues with developing this type of biosensor system. Many modern nanotechnology efforts allowed for the development of innovative electrochemical biosensors with high sensitivity by employing various nanomaterials that facilitate the electron transfer and carrying capacity of signal tracers in combination with surface modification and bioconjugation techniques...
January 12, 2018: Sensors
https://www.readbyqxmd.com/read/29327112/simultaneous-pre-concentration-and-separation-on-simple-paper-based-analytical-device-for-protein-analysis
#5
Ji-Cheng Niu, Ting Zhou, Li-Li Niu, Zhen-Sheng Xie, Fang Fang, Fu-Quan Yang, Zhi-Yong Wu
In this work, fast isoelectric focusing (IEF) was successfully implemented on an open paper fluidic channel for simultaneous concentration and separation of proteins from complex matrix. With this simple device, IEF can be finished in 10 min with a resolution of 0.03 pH units and concentration factor of 10, as estimated by color model proteins by smartphone-based colorimetric detection. Fast detection of albumin from human serum and glycated hemoglobin (HBA1c) from blood cell was demonstrated. In addition, off-line identification of the model proteins from the IEF fractions with matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS) was also shown...
January 11, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29320558/thrombolysis-in-stroke-patients-comparability-of-point-of-care-versus-central-laboratory-international-normalized-ratio
#6
Ramona C Dolscheid-Pommerich, Sarah Dolscheid, Lars Eichhorn, Birgit Stoffel-Wagner, Ingo Graeff
BACKGROUND: In acute stroke patients, thrombolysis is one gold standard therapy option within the first four hours after the ischemic event. A contraindication for thrombolysis is an International Normalized Ratio (INR) value >1.7. Since time is brain, rapid and reliable INR results are fundamental. Aim was to compare INR values determined by central laboratory (CL) analyzer and Point-of-Care Testing(POCT)-device and to evaluate the quality of POCT performance in cases of potential therapeutic thrombolysis at a certified stroke unit...
2018: PloS One
https://www.readbyqxmd.com/read/29249206/early-health-technology-assessment-of-future-clinical-decision-rule-aided-triage-of-patients-presenting-with-acute-chest-pain-in-primary-care
#7
Robert T A Willemsen, Michelle M A Kip, Hendrik Koffijberg, Ron Kusters, Frank Buntinx, Jan F C Glatz, Geert Jan Dinant
The objective of the paper is to estimate the number of patients presenting with chest pain suspected of acute coronary syndrome (ACS) in primary care and to calculate possible cost effects of a future clinical decision rule (CDR) incorporating a point-of-care test (PoCT) as compared with current practice. The annual incidence of chest pain, referrals and ACS in primary care was estimated based on a literature review and on a Dutch and Belgian registration study. A health economic model was developed to calculate the potential impact of a future CDR on costs and effects (ie, correct referral decisions), in several scenarios with varying correct referral decisions...
December 18, 2017: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/29223966/advancing-point-of-care-diagnostics-for-the-control-and-prevention-of-stis-the-way-forward
#8
Igor Toskin, Karel Blondeel, Rosanna W Peeling, Carolyn Deal, James Kiarie
WHO recognises the global impact of sexually transmitted infections (STIs) on global public health and individual sexual and reproductive health and well-being. As a component of the WHO Global Health Sector Strategy for the control and prevention of STIs, there has been a growing recognition of the importance of integrating point-of-care tests (POCTs) into overall strategic planning. The process of integrating STI POCTs, in addition to providing a definitive diagnosis and appropriate treatment in a single visit, also includes innovative delivery options, such as on-site delivery, community-based testing (including screening), as well as self-testing at home after purchase of a test online or over-the-counter...
December 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29223965/advancing-prevention-of-sexually-transmitted-infections-through-point-of-care-testing-target-product-profiles-and-landscape-analysis
#9
Igor Toskin, Maurine Murtagh, Rosanna W Peeling, Karel Blondeel, Joanna Cordero, James Kiarie
OBJECTIVES: Advancing the field of point-of-care testing (POCT) for STIs can rapidly and substantially improve STI control and prevention by providing targeted, essential STI services (case detection and screening). POCT enables definitive diagnosis and appropriate treatment in a single visit and home and community-based testing. METHODS: Since 2014, the WHO Department of Reproductive Health and Research, in collaboration with technical partners, has completed four landscape analyses of promising diagnostics for use at or near the point of patient care to detect syphilis, Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis and the human papillomavirus...
December 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29223963/field-evaluation-of-two-point-of-care-tests-for-syphilis-among-men-who-have-sex-with-men-verona-italy
#10
Antonella Zorzi, Maddalena Cordioli, Lorenzo Gios, Paola Del Bravo, Igor Toskin, Rosanna W Peeling, Karel Blondeel, Giuseppe Cornaglia, James Kiarie, Ronald Ballard, Massimo Mirandola
OBJECTIVES: The incidence of HIV and syphilis among men who have sex with men (MSM) in Europe has recently increased. Rapid point-of-care tests (POCTs) for syphilis can improve access to screening. The purpose of this study was to evaluate the performance of two syphilis POCTs compared with laboratory tests among MSM. METHODS: The study was undertaken in Verona, Italy. Asymptomatic MSM, potentially exposed to syphilis, were enrolled prospectively. The POCTs evaluated were SD Bioline Syphilis 3...
December 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29223960/systematic-reviews-of-point-of-care-tests-for-the-diagnosis-of-urogenital-chlamydia-trachomatis-infections
#11
REVIEW
Helen Kelly, Cordelia E M Coltart, Nitika Pant Pai, Jeffrey D Klausner, Magnus Unemo, Igor Toskin, Rosanna W Peeling
BACKGROUND: WHO estimates that 131 million new cases of urogenital Chlamydia trachomatis (CT) infections occur globally every year. Most infections are asymptomatic. Untreated infection in women can lead to severe complications. Screening and treatment of at-risk populations is a priority for prevention and control. OBJECTIVES: To summarise systematic reviews of the performance characteristics of commercially available point-of-care tests (POCT) for screening and diagnosis of urogenital CT infection...
December 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29223959/performance-and-operational-characteristics-of-point-of-care-tests-for-the-diagnosis-of-urogenital-gonococcal-infections
#12
REVIEW
Rebecca J Guy, Louise M Causer, Jeffrey D Klausner, Magnus Unemo, Igor Toskin, Anna M Azzini, Rosanna W Peeling
BACKGROUND: In 2012, there was an estimated 78 million new cases of gonorrhoea globally. Untreated infection may lead to reproductive and neonatal morbidity and facilitate HIV transmission. Diagnosis and treatment are a priority for control and prevention, yet use of point-of-care tests (POCTs) for Neisseria gonorrhoeae (NG) is limited. OBJECTIVES: To review the performance and operational characteristics of NG POCTs for diagnosis of urogenital gonorrhoea. METHODS: We compiled and synthesised findings from two separate systematic reviews which included evaluations published until August 2015...
December 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29204476/data-documenting-the-performance-of-the-pt-inr-line-correction-method-for-reconciling-inr-discrepancies-between-central-laboratory-coagulation-analyzers-using-different-thromboplastins-during-the-evaluation-of-a-portable-coagulometer
#13
Wendy S Baker, Kathleen J Albright, Heidi Spratt, Megan Berman, Peggy A Mann, Jaime Unabia, John R Petersen
The data presented here was produced as part of an evaluation of the performance of the CoaguChek XS point-of-care coagulation analyzer, which is discussed in the research article "POCT PT INR - Is it adequate for Patient Care? A Comparison of the Roche Coaguchek XS vs. Stago Star vs. Siemens BCS in Patients Routinely Seen in an Anticoagulation Clinic" (Baker et al., in press) [1]. An effort to reconcile discrepancies in the patient INR result distributions from different central lab instruments (Stago Star and Siemens BCS) with the PT/INR line method is described (Poller et al...
February 2018: Data in Brief
https://www.readbyqxmd.com/read/29204328/the-role-of-affordable-point-of-care-technologies-for-cancer-care-in-low-and-middle-income-countries-a-review-and-commentary
#14
Karen Haney, Pushpa Tandon, Rao Divi, Miguel R Ossandon, Houston Baker, Paul C Pearlman
As the burden of non-communicable diseases such as cancer continues to rise in low- and middle-income countries (LMICs), it is essential to identify and invest in promising solutions for cancer control and treatment. Point-of-care technologies (POCTs) have played critical roles in curbing infectious disease epidemics in both high- and low-income settings, and their successes can serve as a model for transforming cancer care in LMICs, where access to traditional clinical resources is often limited. The versatility, cost-effectiveness, and simplicity of POCTs warrant attention for their potential to revolutionize cancer detection, diagnosis, and treatment...
2017: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/29199749/non-invasive-detection-of-gastric-cancer-relevant-d-amino-acids-with-luminescent-dna-silver-nanoclusters
#15
Zhikun Zhang, Yang Liu, Peifeng Liu, Lu Yang, Xingyu Jiang, Dan Luo, Dayong Yang
Chirality plays essential roles in life systems such that l-amino acids (LAAs) are predominantly found as the building units of protein for organisms. The presence of the d-enantiomer (DAA) has been found to be specifically relevant to gastric cancer. We herein construct a luminescent DNA/silver nanocluster based biosensing system to achieve rapid and specific detection of DAAs. As a proof of application, we detected DAAs in saliva samples from patients with gastric cancer, and the test results exhibited excellent specificity...
December 4, 2017: Nanoscale
https://www.readbyqxmd.com/read/29199548/abstracts-of-the-third-national-poct-symposium-antwerp-belgium-march-17th-2017
#16
(no author information available yet)
No abstract text is available yet for this article.
November 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29199450/validity-of-two-poct-glucose-measurement-devices-in-hypoglycaemia-how-reliable-is-my-result
#17
Rolf Bikker, Denis Grote-Koska, Petra Domberg, Korbinian Brand
No abstract text is available yet for this article.
December 3, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29196186/implementation-of-an-expanded-point-of-care-site-inspection-checklist-in-an-academic-medical-center-an-eight-year-experience
#18
Simran Khanna, Jason Baron, Kimberly Gregory, Kent Lewandrowski
BACKGROUND: We evaluated the effectiveness of an expanded point-of-care (POCT) site inspection checklist over an extended 8-y period. METHODS: A retrospective review of site inspection deficiency reports in a large academic medical center from 2010 to 2017 (year to date). RESULTS: There was a significant decrease in the number of cited deficiencies per site/inspection from 2010 (3.17) to 2017 (0.27) (p<0.001). The percentage of sites without deficiencies steadily increased from 2010 (8...
November 28, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29186872/pre-clinical-tests-of-an-integrated-cmos-biomolecular-sensor-for-cardiac-diseases-diagnosis
#19
Jen-Kuang Lee, I-Shun Wang, Chi-Hsien Huang, Yih-Fan Chen, Nien-Tsu Huang, Chih-Ting Lin
Coronary artery disease and its related complications pose great threats to human health. In this work, we aim to clinically evaluate a CMOS field-effect biomolecular sensor for cardiac biomarkers, cardiac-specific troponin-I (cTnI), N-terminal prohormone brain natriuretic peptide (NT-proBNP), and interleukin-6 (IL-6). The CMOS biosensor is implemented via a standard commercialized 0.35 μm CMOS process. To validate the sensing characteristics, in buffer conditions, the developed CMOS biosensor has identified the detection limits of IL-6, cTnI, and NT-proBNP as being 45 pM, 32 pM, and 32 pM, respectively...
November 26, 2017: Sensors
https://www.readbyqxmd.com/read/29169287/point-of-care-testing-poct-and-evidence-based-laboratory-medicine-eblm-does-it-leverage-any-advantage-in-clinical-decision-making
#20
Christopher Florkowski, Andrew Don-Wauchope, Nuria Gimenez, Karina Rodriguez-Capote, Julien Wils, Annalise Zemlin
Point-of-care testing (POCT) is the analysis of patient specimens outside the clinical laboratory, near or at the site of patient care, usually performed by clinical staff without laboratory training, although it also encompasses patient self-monitoring. It is able to provide a rapid result near the patient and which can be acted upon immediately. The key driver is the concept that clinical decision making may be delayed when samples are sent to the clinical laboratory. Balanced against this are considerations of increased costs for purchase and maintenance of equipment, staff training, connectivity to the laboratory information system (LIS), quality control (QC) and external quality assurance (EQA) procedures, all required for accreditation under ISO 22870...
November 23, 2017: Critical Reviews in Clinical Laboratory Sciences
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