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Won-Yong Jeon, Young-Bong Choi, Hyug-Han Kim
Applying a nanocomposite to increase the conductivity of an electrode can facilitate electrochemical analysis. In this regard, multi-walled carbon nanotubes (MWCNTs) evenly dispersed in hydrophilic solution can play an important role in electrochemical bio-sensing due to their unique properties, such as their high electrical conductivity and ability to conjugate with hydrophilic enzymes. Herein, we report the simple ultrasonic synthesis of a highly dispersible, enzyme-binding nanocomposite, poly(acrylamide)-co-poly(vinyl imidazole) (7:1 mol ratio)-MWCNTs (PAA-PVI@MWCNTs)...
May 2018: Ultrasonics Sonochemistry
Anna Köchling, Christin Löffler, Stefan Reinsch, Anne Hornung, Femke Böhmer, Attila Altiner, Jean-François Chenot
BACKGROUND: Although most respiratory tract infections (RTIs) are due to viral infections, they cause the majority of antibiotic (Abx) prescriptions in primary care. This systematic review summarises the evidence on the effectiveness of interventions in primary care aiming to reduce Abx prescriptions in patients ≥ 13 years for acute RTI. METHODS: We searched the databases "MEDLINE/PubMed" and "Cochrane Library" for the period from January 1, 2005, to August 31, 2016, for randomised controlled trials (RCTs) in primary care aiming at the reduction of Abx prescriptions for patients suffering from RTI...
March 20, 2018: Implementation Science: IS
Sarah Hindenberg, Melanie Keßler, Sabine Zielinsky, Judith Langenstein, Andreas Moritz, Natali Bauer
BACKGROUND: Species-specific point-of-care tests (POCT) permit a rapid analysis of canine C-reactive protein (CRP), enabling veterinarians to include CRP in clinical decisions. Aim of the study was to evaluate a novel POCT for canine CRP (Point Strip™ Canine CRP Assay) run on a small in-house-analyzer (Point Reader™ V) using lithium heparin plasma and to compare assay performance to an already established canine CRP assay (Gentian Canine CRP Immunoassay) run on two different bench top analyzers serving as reference methods (ABX Pentra 400, AU 5800)...
March 20, 2018: BMC Veterinary Research
Karl-Heinz Patzer, Payam Ardjomand, Katharina Göhring, Guido Klempt, Andreas Patzelt, Markus Redzich, Mathias Zebrowski, Susanne Emmerich, Oliver Schnell
BACKGROUND: Medical practices face challenges of time and cost pressures with scarce resources. Point-of-care testing (POCT) has the potential to accelerate processes compared to central laboratory testing and can increase satisfaction of physicians, staff members, and patients. The objective of this study was to evaluate the effects of introducing HbA1c POCT in practices specialized in diabetes. METHOD: Three German practices that manage 400, 550, and 950 diabetes patients per year participated in this evaluation...
March 1, 2018: Journal of Diabetes Science and Technology
Teddy Léguillier, Romain Jouffroy, Marie Boisson, Agathe Boussaroque, Camille Chenevier-Gobeaux, Tarek Chaabouni, Benoît Vivien, Valérie Nivet-Antoine, Jean-Louis Beaudeux
AIM OF THE STUDY: We evaluated if the StatStrip Xpress Meter, a Lactate point of care testing (POCT) handled device, could be a valuable tool in the mobile intensive care units (MICU) to assess the severity of septic patients. METHODS: We first investigated POCT analytical performance, then, using samples collected from 50 identified septic patients admitted to the intensive care unit (ICU), we compared lactate values obtained with the device to those obtained with four central laboratory analysers: one whole blood and three plasma-based methods...
March 6, 2018: Clinical Biochemistry
Marian Krawczyk, Richard Sawatzky
OBJECTIVES: This study is part of an overarching research initiative on the development and integration of an electronic Quality of Life and Practice Support System (QPSS) that uses patient-reported outcome and experience measures in clinical practice. The current study focused on palliative nurse consultants trialing the QPSS with older hospitalized adults receiving acute care. The primary aim of the study was to better understand consultants' and patients' experiences and perspectives of use...
March 8, 2018: Palliative & Supportive Care
Linfei Zhu, Qixuan Guo, Xinxin Lu, Junhua Zhao, Jinxin Shi, Zhenning Wang, Xin Zhou
BACKGROUND Ovarian cancer is the most lethal malignant tumor of the female reproductive system, and the metastasis is one of the major factors that contribute to the poor outcome of patients with OC. Accumulating evidence indicates that lncRNAs are expressed and play important regulatory roles in ovarian cancer. MATERIAL AND METHODS Aberrant lncRNAs in primary ovarian cancer tissues (POCTs) and paired omental metastasis tissues (OMTs) of patients with HGSOC were studied via lncRNA microarray. Real-time PCR was performed to examine CTD-2020K17...
March 5, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Lingxian Ye, Guangying Zhao, Wenchao Dou
A sensitive Point-of-Care Testing (POCT) with Au-Pt bimetallic nanoparticles (Au@Pt) functionalized silica nanoparticle (SiO2 NPs) and Fe3 O4 magnetic nanoparticles (Fe3 O4 NPs) was designed for the quantitative detection of Escherichia coli O157:H7 (E. coli O157:H7). The poly-(4-styrenesulfonic acid-co-maleic acid) (PSSMA) as a negatively charged polyelectrolyte can be easily coated on surface of the amino group modified SiO2 NPs via electrostatic force. PSSMA is also a good stabilizer for water-soluble bimetallic nanostructures...
May 15, 2018: Talanta
Marco J Haenssgen, Nutcha Charoenboon, Thomas Althaus, Rachel C Greer, Daranee Intralawan, Yoel Lubell
New and affordable point-of-care testing (POCT) solutions are hoped to guide antibiotic prescription and to help limit antimicrobial resistance (AMR)-especially in low- and middle-income countries where resource constraints often prevent extensive diagnostic testing. Anthropological and sociological research has illuminated the role and impact of rapid point-of-care malaria testing. This paper expands our knowledge about the social implications of non-malarial POCT, using the case study of a C-reactive-protein point-of-care testing (CRP POCT) clinical trial with febrile patients at primary-care-level health centres in Chiang Rai province, northern Thailand...
February 23, 2018: Social Science & Medicine
Hui Chen, Yanqi Wu, Zhu Chen, Zhili Hu, Yile Fang, Pei Liao, Yan Deng, Nongyue He
In recent years, the prevention, control, diagnosis and treatment of infectious diseases has become a global focus for public health. Traditional methods for pathogen testing have some major disadvantages including the need for highly skilled staff and expensive instrumentation, while procedural aspects are complex and sensitive to the environment. These shortcomings have greatly limited the application of traditional testing in on site pathogen detection. In this paper, we present a new point-of-care-testing (POCT) system based on magnetic nanoparticles that enable sample in-answer out (SIAO) automated real-time testing for pathogens...
December 1, 2017: Journal of Biomedical Nanotechnology
Christopher C Butler, Nick A Francis, Emma Thomas-Jones, Mirella Longo, Mandy Wootton, Carl Llor, Paul Little, Michael Moore, Janine Bates, Timothy Pickles, Nigel Kirby, David Gillespie, Kate Rumsby, Curt Brugman, Micaela Gal, Kerenza Hood, Theo Verheij
BACKGROUND: The effectiveness of using point-of-care (POC) urine culture in primary care on appropriate antibiotic use is unknown. AIM: To assess whether use of the Flexicult™ SSI-Urinary Kit, which quantifies bacterial growth and determines antibiotic susceptibility at the point of care, achieves antibiotic use that is more often concordant with laboratory culture results, when compared with standard care. DESIGN AND SETTING: Individually randomised trial of females with uncomplicated urinary tract infection (UTI) in primary care research networks (PCRNs) in England, the Netherlands, Spain, and Wales...
February 26, 2018: British Journal of General Practice: the Journal of the Royal College of General Practitioners
Carlos E S Ferreira, Joao C C Guerra, Natasha Slhessarenko, Marileia Scartezini, Carolina N Franca, Marjorie P Colombini, Fernando Berlitz, Antonia M O Machado, Gustavo A Campana, Adriana C L Faulhaber, Cesar A Galoro, Claudia M Dias, Wilson Shcolnik, Marines D V Martino, Katia R Cesar, Nairo M Sumita, Maria E Mendes, Marcelo H W Faulhaber, Joao R R Pinho, Ismar V Barbosa, Marcelo C Batista, Cristina Khawali, Vitor M Pariz, Adagmar Andriolo
Point-of-Care Testing (POCT) has been highlighted in the health care sector in recent decades. On the other hand, due to its low demand, POCT is at a disadvantage compared to conventional equipment, since its cost is inversely proportional to the volume of use. In addition, for the implementation of POCT to succeed, it is essential to rely on the work of a multidisciplinary team. The awareness of health professionals of the importance of each step is perhaps the critical success factor. The trend towards the continuous advancement of the use of POCT and the great potential of its contributions reinforce the need to implement quality management tools, including performance indicators, to ensure their results...
January 1, 2018: Clinical Laboratory
Edward Tieru Dassah, Yaw Adu-Sarkodie, Philippe Mayaud
BACKGROUND: Effective implementation of rapid point of care tests (POCTs) for antenatal syphilis screening especially in settings where antenatal care attendance is high, can significantly increase screening coverage and treatment uptake. The operational challenges of introducing rapid syphilis POCTs at scale needs to be investigated. This study explores healthcare providers' experiences and challenges in antenatal syphilis screening following the national rollout of rapid syphilis POCTs in Ghana...
February 20, 2018: BMC Health Services Research
Lin Chen, Huagui Wang, Tongsheng Guo, Chaohui Xiao, Licheng Liu, Xiaoguang Zhang, Bo Liu, Peiran Li, Aixia Liu, Bo Li, Boan Li, Yuanli Mao
Dengue fever is caused by the dengue virus (DENV), and DENV1 is the prevalent epidemic serotype in south China. A new lateral flow assay (LFA) based on a near-infrared (NIR) fluorescent dye was developed to detect anti-DENV1 IgG antibodies. DyLight-800 was used as the marker conjugated to goat anti-human IgG antibodies, and recombinant dengue type 1 envelope protein was used as the capture protein on the test line. Twenty samples from patients infected with DENV1 and 160 negative controls were analyzed using this new NIR-LFA...
February 15, 2018: Journal of Immunological Methods
Xiaonan Liu, Chao Zhang, Kewu Liu, Han Wang, Chaoxia Lu, Hang Li, Kai Hua, Juanli Zhu, Wenli Hui, Yali Cui, Xue Zhang
Single nucleotide polymorphisms (SNPs) are closely related to genetic diseases, but current SNP detection methods, such as DNA microarrays that include tedious procedures and expensive, sophisticated instruments, are unable to perform rapid SNPs detection in clinical practice, especially for those multiple SNPs related to genetic diseases. In this study, we report a sensitive, low cost, and easy-to-use point-of-care testing (POCT) system formed by combining amplification refractory mutation system (ARMS) polymerase chain reaction with gold magnetic nanoparticles (GMNPs) and lateral flow assay (LFA) noted as the ARMS-LFA system, which allow us to use a uniform condition for multiple SNPs detection simultaneously...
February 16, 2018: Analytical Chemistry
Yonghun Lee, Dong-Min Kim, Zhenglin Li, Dong-Eun Kim, Sung-Jin Kim
We demonstrate a microfiltration chip that separates blood plasma by using water-head-driven pulsatile pressures rather than any external equipment and use it for on-chip amplification of nucleic acids. The chip generates pulsatile pressures to significantly reduce filter clogging without hemolysis, and consists of an oscillator, a plasma-extraction pump, and filter units. The oscillator autonomously converts constant water-head pressure to pulsatile pressure, and the pump uses the pulsatile pressure to extract plasma through the filter...
February 15, 2018: Lab on a Chip
Yujin Xu, Jianqiang Li, Jin Wang, Xiao Hu, Honglian Ma, Pu Li, Xiao Zheng, Ming Chen
The function of postoperative radiotherapy (PORT) in patients with completely resected pathologically N2 (pN2) non-small cell lung cancer (NSCLC) remains controversial due to a lack of prospective studies. The present study aimed to evaluate the efficacy of PORT in completely resected pN2 NSCLC when using modern radiation techniques, and to determine the associations between clinicopathological factors and PORT and survival rates. Following patient selection, 246 out of 269 consecutive patients with pN2 NSCLC were enrolled in the present study, with 88 patients having received postoperative chemotherapy (POCT) and PORT, 90 having received adjuvant chemotherapy, 1 having received adjuvant radiotherapy and the remaining 67 having received no adjuvant therapy...
February 2018: Oncology Letters
Di Zhang, Li Huang, Bing Liu, Haibin Ni, Liangdong Sun, Enben Su, Hongyuan Chen, Zhongze Gu, Xiangwei Zhao
Rapid and sensitive quantification of multiplex proteins in a wide concentration range is challenging in high throughput analysis. Herein, we proposed a lateral flow assay (LFA) based on core-shell surface enhanced Raman scattering (SERS) nanotags for multiplex and quantitative detection of cardiac biomarkers for the early diagnosis of acute myocardial infarction (AMI). In practice, Raman dyes (RDs) were embedded into the interior-gap of silver core and gold shell nanoparticles (NPs) to form SERS nanotags as labels instead of gold colloids and three test lines were employed in the strip for the detection of three cardiac biomarkers, Myo, cTnI, and CK-MB, respectively...
February 1, 2018: Biosensors & Bioelectronics
Christoph D Spinner, Matthias C Müller, Berit Lange
Bedside laboratory procedures so called "point of care testing - POCT" plays an emerging role in clinical routine practice. While glucose or urine protein screening has been established since a while, newer lateral flow assays (LFID), mostly as rapid diagnostic tests (RDT), play and upcoming role, as well as nucleic amplification based and micro carrier based systems. Hereby an accurate and precise diagnostic allows clinical decisions; in infectious diseases as well as other disciplines in medicine. All test are limited by sensitivity and specifity...
February 2018: Deutsche Medizinische Wochenschrift
S Padayattil Jose, A Banzato, P Carraro, A Haleh, K Rossi, G Nante, G Denas, G Zoppellaro, V Pengo
BACKGROUND: Non-vitamin K antagonist oral anticoagulants (NOACs) do not need routine laboratory monitoring but measurement of drug concentration is important in emergency conditions. Specific laboratory tests are not readily available or not implemented in every hospital. Point-of-Care Tests (POCT) may bridge this gap and be used as a bedside solution. OBJECTIVES: Feasibility of POCT to assess plasma levels of dabigatran, rivaroxaban and apixaban. PATIENTS/METHODS: Activated Coagulation Time-Low Range (ACT - LR) using a portable Hemochron Signature Elite for dabigatran and prothrombin time (expressed as INR) by Coaguchek XS Pro for rivaroxaban and apixaban were obtained at trough and peak in 136 consecutive patients taking NOACs (70 on dabigatran, 45 on rivaroxaban and 20 on apixaban)...
January 30, 2018: Thrombosis Research
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