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https://www.readbyqxmd.com/read/28904181/progress-and-challenges-towards-point-of-care-diagnostic-development-for-dengue
#1
Junxiong Pang, Po Ying Chia, David C Lye, Yee Sin Leo
Dengue detection strategies involve viral RNA, antigen and/or antibody detection. Each strategy has its advantages and disadvantages. Optimal, user-friendly and rapid diagnostic tests based on immunochromatographic assays are pragmatic point-of-care-test (POCT) in dengue endemic regions where there are limited laboratory capabilities and optimal storage conditions. Increasingly, there is a greater public health significance for multiplexing assay to differentiate dengue from Zika or pathogens with similar clinical presentations...
September 13, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28872272/understanding-low-sensitivity-of-community-based-hiv-rapid-testing-experiences-from-the-hptn-071-popart-trial-in-zambia-and-south-africa
#2
Peter Bock, Comfort Phiri, Estelle Piwowar-Manning, Barry Kosloff, Nomtha Mandla, Alicia Young, Anelet James, Ab Schaap, Michelle Scheepers, Deborah Donnell, Sam Griffith, Wafaa El-Sadr, Kwame Shanaube, Nulda Beyers, Richard Hayes, Sarah Fidler, Helen Ayles
INTRODUCTION: Population-wide HIV testing services (HTS) must be delivered in order to achieve universal antiretroviral treatment (ART) coverage. To accurately deliver HTS at such scale, non-facility-based HIV point-of-care testing (HIV-POCT) is necessary but requires rigorous quality assurance (QA). This study assessed the performance of community-wide HTS in Zambia and South Africa (SA) as part of the HPTN 071 (PopART) study and explores the impact of quality improvement interventions on HTS performance...
August 29, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28856223/comparison-of-a-point-of-care-analyser-for-the-determination-of-hba1c-with-hplc-method
#3
D A Grant, G J Dunseath, R Churm, S D Luzio
AIMS: As the use of Point of Care Testing (POCT) devices for measurement of glycated haemoglobin (HbA1c) increases, it is imperative to determine how their performance compares to laboratory methods. This study compared the performance of the automated Quo-Test POCT device (EKF Diagnostics), which uses boronate fluorescence quenching technology, with a laboratory based High Performance Liquid Chromatography (HPLC) method (Biorad D10) for measurement of HbA1c. METHODS: Whole blood EDTA samples from subjects (n=100) with and without diabetes were assayed using a BioRad D10 and a Quo-Test analyser...
August 2017: Pract Lab Med
https://www.readbyqxmd.com/read/28855485/potential-of-next-generation-poct-in-infectious-disease-rapid-test
#4
Naoto Shimetani
Real-time test results are necessary for early diagnosis and in determining treatment orientation in medical practice. Point of Care Testing (POCT) is a testing system that provides beneficial and helpful information for diagnosis and treatment through real-time testing at the bedside. Therefore, POCT has high utility value in the field of infectious diseases as a rapid test that provides, within the consultation hours, useful information for initial treatment.Infectious disease rapid test kits are commercially available for a wide variety of prophlogistic pathogen targets, including bacterial, viral, fungal, protozoal, and other disease agents...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/28834598/comparison-of-noninvasive-and-invasive-point-of-care-testing-methods-with-reference-method-for-hemoglobin-measurement
#5
Gamze Avcioglu, Cemil Nural, Fatma Meriç Yilmaz, Pervin Baran, Özcan Erel, Gülsen Yilmaz
BACKGROUND: Rapid and practical point-of-care testing (POCT) devices become more popular, especially in blood donation centers for determining predonation hemoglobin (Hb) concentrations. The purpose of this study was to evaluate accordance between the POCT methods and the venous method as the reference to Hb screening. METHODS: A total of 353 subjects with no known significant health problems were included in the study. Hb screening was performed by two different POCT methods, a noninvasive method (Haemospect, MBR, Germany) and an invasive method (HemoControl, EKF Diagnostic, Germany), and a venous method as the reference (Sysmex XE-2100, Sysmex Europe, Germany)...
August 23, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28830683/implementation-of-point-of-care-testing-in-a-general-internal-medicine-practice-a-confirmation-study
#6
Elizabeth-Lee Lewandrowski, Sunu Yeh, Jason Baron, J Benjamin Crocker, Kent Lewandrowski
BACKGROUND: In a previous study we reported on the impact of point-of-care testing (POCT) on practice efficiency in an academic primary care practice that was established to develop new models of care delivery. Here we report a follow-on confirmation study in a more typical primary care practice in the community. METHODS: In this observational study with a retrospective comparison analysis we measured metrics of practice efficiency on two patient cohorts: those that did not receive POCT and those that did...
October 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28818691/multi-center-evaluation-of-the-cobas-%C3%A2-liat-%C3%A2-influenza-a-b-rsv-assay-for-rapid-point-of-care-diagnosis
#7
Jane Gibson, Elissa M Schechter-Perkins, Patricia Mitchell, Sharon Mace, Yu Tian, Kemi Williams, Robert Luo, Belinda Yen-Lieberman
Point of Care Testing (POCT) provides the capability for rapid laboratory test results in patient care environments where a traditional clinical laboratory is not available. POCTs have shorter turn-around times (TATs), they may be performed by non-laboratory personnel, and the need for transport time is eliminated. The Food and Drug Administration (FDA) recently granted Clinical Laboratory Improvements Amendment (CLIA) waiver status to the cobas(®) Influenza A/B & RSV assay, a rapid, accurate point-of-care test for Influenza and respiratory syncytial virus (RSV) performed on the Liat(®) System...
August 8, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28814583/does-use-of-point-of-care-testing-improve-cost-effectiveness-of-the-nhs-health-check-programme-in-the-primary-care-setting-a-cost-minimisation-analysis
#8
Austen El-Osta, Maria Woringer, Elena Pizzo, Talitha Verhoef, Claire Dickie, Melody Z Ni, Jeremy R Huddy, Michael Soljak, George B Hanna, Azeem Majeed
OBJECTIVE: To determine if use of point of care testing (POCT) is less costly than laboratory testing to the National Health Service (NHS) in delivering the NHS Health Check (NHSHC) programme in the primary care setting. DESIGN: Observational study and theoretical mathematical model with microcosting approach. SETTING: We collected data on NHSHC delivered at nine general practices (seven using POCT; two not using POCT). PARTICIPANTS: We recruited nine general practices offering NHSHC and a pathology services laboratory in the same area...
August 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28811237/the-in-validity-of-volatile-poct-parameters-from-patients-beyond-normothermia
#9
Michael A Gruber, Stefan Felbermeir, Regina Lindner, Martin Kieninger
BACKGROUND: A common characteristic of all blood gas analyzers on the market is that measurements are processed at 37°C, not at the real patients´ temperature. Subsequently temperature-sensitive parameters can be mathematically corrected (alpha-stat method) or used directly (pH-stat method). National rules in Germany (Rili-BAEK) demand defined accuracy and precision without any restriction to samples´ temperatures or corrections. As consequence in the investigation at hand we tried to find out whether blood gas analyzers can fulfill the regulations for pCO2 and pO2 when normothermia of the matrix is not given...
October 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28807759/development-of-a-highly-resolved-loop-mediated-isothermal-amplification-method-to-detect-the-n526k-ftsi-mutation-of-%C3%AE-lactamase-negative-ampicillin-resistant-haemophilus-influenzae
#10
Shinsuke Tamura, Takuya Maeda, Kazuhisa Misawa, Morichika Osa, Takaaki Hamamoto, Atsushi Yuki, Kazuo Imai, Kei Mikita, Kyoko Morichika, Akihiko Kawana, Hiroshi Matsumoto, Shigeaki Nonoyama
Rapid and easy detection of sequence polymorphisms, including nucleotide point mutations of bacterial pathogens responsible for amino acid substitutions linked to drug resistance, is essential for the proper use of antimicrobial agents. Here, a detection method using loop-mediated amplification (LAMP) combined with amplification refractory mutation system (ARMS) to accurately distinguish a different single nucleotide in the target sequence was established, named ARMS-SNP LAMP. This procedure is capable of species-specific detection of a nucleotide (1578T) in the ftsI gene on Haemophilus influenzae without amplifying the sequence carrying the point mutations (T1578G/A) in β-lactamase-negative ampicillin resistant (BLNAR) strains...
August 12, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28803961/the-99th-percentile-and-imprecision-of-point-of-care-cardiac-troponin-i-in-comparison-to-central-laboratory-tests-in-a-large-reference-population
#11
Anne Greiser, Theresa Winter, Hala Mahfoud, Anders Kallner, Till Ittermann, Annette Masuch, Norbert Lubenow, Thomas Kohlmann, Andreas Greinacher, Matthias Nauck, Astrid Petersmann
OBJECTIVES: Determination of cardiac troponin (cTn) is central in the emergency department (ED) for the diagnosis of myocardial infarction. In view of adverse effects of long waiting time on patient outcome, implementation of point-of-care-testing (POCT) is suggested if the turn-around-time is longer than 60min. The present study aimed to determine the 99th percentile and imprecision of two POCT in a healthy population measuring cTnI and cTnT and compare these analytical characteristics against three central laboratory test (CLT) for cTnI...
August 10, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28774502/poct-pt-inr-is-it-adequate-for-patient-care-a-comparison-of-the-roche-coaguchek-xs-vs-stago-star-vs-siemens-bcs-in-patients-routinely-seen-in-an-anticoagulation-clinic
#12
Wendy S Baker, Kathleen J Albright, Megan Berman, Heidi Spratt, Peggy A Mann, Jaime Unabia, John R Petersen
BACKGROUND: In this study we examined the difference in patient INR values as measured by the POCT CoaguChek XS device and central laboratory Stago Evolution and Siemens BCS XP analyzers. METHODS: This study composed of 100 warfarin therapy patients and 20 coagulation normal subjects, showed that the difference between the POCT and clinical laboratory values increased with increasing INR and was exacerbated by the use of different thromboplastin reagents by the POCT and central lab...
August 1, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28771209/point-of-care-testing-in-acute-stroke-management-an-unmet-need-ripe-for-technological-harvest
#13
REVIEW
Dorin Harpaz, Evgeni Eltzov, Raymond C S Seet, Robert S Marks, Alfred I Y Tok
Stroke, the second highest leading cause of death, is caused by an abrupt interruption of blood to the brain. Supply of blood needs to be promptly restored to salvage brain tissues from irreversible neuronal death. Existing assessment of stroke patients is based largely on detailed clinical evaluation that is complemented by neuroimaging methods. However, emerging data point to the potential use of blood-derived biomarkers in aiding clinical decision-making especially in the diagnosis of ischemic stroke, triaging patients for acute reperfusion therapies, and in informing stroke mechanisms and prognosis...
August 3, 2017: Biosensors
https://www.readbyqxmd.com/read/28756433/point-of-care-testing-across-rural-and-remote-emergency-departments-in-australia-staff-perceptions-of-operational-impact
#14
Maria R Dahm, Euan McCaughey, Ling Li, Johanna Westbrook, Virginia Mumford, Juliana Iles-Mann, Andrew Sargeant, Andrew Georgiou
New South Wales (NSW) Health Pathology is implementing one of the world's largest managed PoCT services across rural and remote Emergency Departments (EDs) in New South Wales, Australia to improve patient access to care. The aim of this qualitative study was to gain a context-rich understanding of the operational impact of the NSW rollout of PoCT across rural and remote ED settings as experienced by frontline clinical staff. Clinical professionals (n=14) participated in interviews and focus groups in August 2015 at four rural and remote NSW EDs...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28750092/cost-effectiveness-of-molecular-point-of-care-testing-for-influenza-viruses-in-elderly-patients-at-ambulatory-care-setting
#15
Joyce H S You, Lok-Pui Tam, Nelson L S Lee
BACKGROUND: Early initiation of antiviral therapy in elderly patients with influenza is associated with reduced risk of extra clinic visit, hospitalization and death. This study examined the cost-effectiveness of molecular POCT for detection of influenza viruses in Hong Kong elderly patients with influenza-like illness (ILI) in the outpatient clinics. METHODS: A decision analytic model was used to simulate outcomes of a hypothetical cohort of elderly patients presented with ILI at outpatient clinics during peak season of influenza with two diagnostic approaches: Rapid molecular assay (POCT-PCR group) and clinical judgement with no POCT...
2017: PloS One
https://www.readbyqxmd.com/read/28740385/application-of-nanodiagnostics-in-point-of-care-tests-for-infectious-diseases
#16
REVIEW
Yongzhong Wang, Li Yu, Xiaowei Kong, Leming Sun
Although tremendous efforts have been put into the treatment of infectious diseases to prevent epidemics and mortality, it is still one of the major health care issues that have a profound impact on humankind. Therefore, the development of specific, sensitive, accurate, rapid, low-cost, and easy-to-use diagnostic tools is still in urgent demand. Nanodiagnostics, defined as the application of nanotechnology to medical diagnostics, can offer many unique opportunities for more successful and efficient diagnosis and treatment for infectious diseases...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28728008/pen-on-paper-strategy-for-point-of-care-testing-rapid-prototyping-of-fully-written-microfluidic-biosensor
#17
Zedong Li, Fei Li, Yue Xing, Zhi Liu, Minli You, Yingchun Li, Ting Wen, Zhiguo Qu, Xiao Ling Li, Feng Xu
Paper-based microfluidic biosensors have recently attracted increasing attentions in point-of-care testing (POCT) territories benefiting from their affordable, accessible and eco-friendly features, where technologies for fabricating such biosensors are preferred to be equipment free, easy-to-operate and capable of rapid prototyping. In this work, we developed a pen-on-paper (PoP) strategy based on two custom-made pens, i.e., a wax pen and a conductive-ink pen, to fully write paper-based microfluidic biosensors through directly writing both microfluidic channels and electrodes...
December 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28728007/direct-immune-detection-of-cortisol-by-chemiresistor-graphene-oxide-sensor
#18
Yo-Han Kim, Kyungmin Lee, Hunsang Jung, Hee Kyung Kang, Jihoon Jo, In-Kyu Park, Hyun Ho Lee
In this study, a biosensor to detect a stress biomarker of cortisol using cortisol monoclonal antibody (c-Mab) covalently immobilized on reduced graphene oxide (rGO) channel as electrical sensing element was demonstrated. Highly specific immune-recognition between the c-Mab and the cortisol was identified and characterized on a basis of resistance change at the rGO channel based chemiresistor sensor achieving the limit of detection of 10pg/mL (27.6 pM). In addition, cortisol concentrations of real human salivary sample and buffer solution of rat adrenal gland acute slices, which could secret the cortisol induced by adrenocorticotropic hormone (ACTH), were directly measured by the chemiresistor corresponding to the specific sensing of the cortisol...
July 11, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28724363/comparing-patient-and-healthcare-worker-experiences-during-a-dengue-outbreak-in-singapore-understanding-the-patient-journey-and-the-introduction-of-a-point-of-care-test-poct-toward-better-care-delivery
#19
Qinghui Tan, Zoe J-L Hildon, Shweta Singh, Jin Jing, Tun Linn Thein, Richard Coker, Hubertus J M Vrijhoef, Yee Sin Leo
BACKGROUND: In the aftermath of an upsurge in the number of dengue cases in 2013 and 2014, the SD BIOLINE Dengue Duo rapid diagnostic Point-of-Care Test (POCT) kit was introduced in Tan Tock Seng Hospital, Singapore in June 2013. It is known that the success of POCT usage is contingent on its implementation within the health system. We evaluated health services delivery and the Dengue Duo rapid diagnostic test kit application in Singapore from healthcare workers' perspectives and patient experiences of dengue at surge times...
July 19, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28721805/automated-one-pot-radiosynthesis-of-11c-s-adenosyl-methionine
#20
Florencia Zoppolo, Williams Porcal, Patricia Oliver, Eduardo Osvaldo Savio, Henry Engler
BACKGROUND: Glycine-N-methyl transferase is an enzyme overexpressed in some neoplastic tissues. It catalyses the methylation of glycine using S-adenosyl methionine (SAM) as co-enzyme. SAM is involved in a great variety of biochemical processes, including transmethylation reactions. Thus, [11C]SAM could be used to evaluate transmethylation activity in tumours. The only method reported for [11C]SAM synthesis is an enzymatic process with several limitations. We propose a new chemical method to obtain [11C]SAM, through a one-pot synthesis...
July 18, 2017: Current Radiopharmaceuticals
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