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https://www.readbyqxmd.com/read/29137903/implementation-of-alere-i-influenza-a-b-point-of-care-test-for-the-diagnosis-of-influenza-in-an-emergency-department
#1
E Trabattoni, V Le, B Pilmis, G Pean de Ponfilly, C Caisso, C Couzigou, B Vidal, A Mizrahi, O Ganansia, A Le Monnier, B Lina, J C Nguyen Van
STUDY OBJECTIVE: This study aimed to evaluate the impact of implementing rapid point-of-care testing (POCT) with the Alere i Influenza A & B in an emergency department (ED) during an influenza epidemic. METHODS: Direct nasal swabs were prospectively collected following the physical examination of patients aged >18years who presented to the ED of a tertiary hospital in France with influenza-like illness (ILI) symptoms (N=301) between February 1st and March 31st, 2016, which coincided with an influenza epidemic...
October 18, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29128713/non-enzymatic-electrochemical-detection-of-glucose-with-a-disposable-paper-based-sensor-using-a-cobalt-phthalocyanine-ionic-liquid-graphene-composite
#2
Sudkate Chaiyo, Eda Mehmeti, Weena Siangproh, Thai Long Hoang, Hai Phong Nguyen, Orawon Chailapakul, Kurt Kalcher
We introduce for the first time a paper-based analytical device (PAD) for the non-enzymatic detection of glucose by modifying a screen-printed carbon electrode with cobalt phthalocyanine, graphene and an ionic liquid (CoPc/G/IL/SPCE). The modifying composite was characterized by UV-visible spectroscopy, energy dispersive X-ray spectroscopy (EDX), transmission electron microscopy (TEM) and scanning electron microscopy (SEM). The disposable devices show excellent conductivity and fast electron transfer kinetics...
November 9, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29128480/rapid-detection-of-haemophilus-parasuis-using-cross-priming-amplification-and-vertical-flow-visualization
#3
Hongchao Gou, Juan Li, Rujian Cai, Shuai Song, Miao Li, Dongxia Yang, Zhiyong Jiang, Yan Li, Pinpin Chu, Chunling Li
Haemophilus parasuis infection is of considerable economic importance in the swine industry due to high morbidity and mortality in naive swine populations. Accurate detection and identification of the causative agent are difficult, yet necessary, for disease control. In this study, a simple and rapid method of cross-priming amplification (CPA) with a vertical flow (VF) visualization strip was established to detect H. parasuis. The reaction can specifically identify 15 serovar reference strains and 57 clinically isolated strains of H...
November 9, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29121557/a-ratiometric-electrochemical-biosensor-for-the-exosomal-micrornas-detection-based-on-bipedal-dna-walkers-propelled-by-locked-nucleic-acid-modified-toehold-mediate-strand-displacement-reaction
#4
Jing Zhang, Liang-Liang Wang, Mei-Feng Hou, Yao-Kun Xia, Wen-Hui He, An Yan, Yun-Ping Weng, Lu-Peng Zeng, Jing-Hua Chen
Sensitive and selective detection of microRNAs (miRNAs) in cancer cells derived exosomes have attracted rapidly growing interest owing to their potential in diagnostic and prognostic applications. Here, we design a ratiometric electrochemical biosensor based on bipedal DNA walkers for the attomolar detection of exosomal miR-21. In the presence of miR-21, DNA walkers are activated to walk continuously along DNA tracks, resulting in conformational changes as well as considerable increases of the signal ratio produced by target-respond and target-independent reporters...
November 1, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29120361/variation-in-point-of-care-testing-of-hba1c-in-diabetes-care-in-general-practice
#5
Troels Kristensen, Frans Boch Waldorff, Jørgen Nexøe, Christian Volmar Skovsgaard, Kim Rose Olsen
Background: Point-of-care testing (POCT) of HbA1c may result in improved diabetic control, better patient outcomes, and enhanced clinical efficiency with fewer patient visits and subsequent reductions in costs. In 2008, the Danish regulators created a framework agreement regarding a new fee-for-service fee for the remuneration of POCT of HbA1c in general practice. According to secondary research, only the Capital Region of Denmark has allowed GPs to use this new incentive for POCT. The aim of this study is to use patient data to characterize patients with diabetes who have received POCT of HbA1c and analyze the variation in the use of POCT of HbA1c among patients with diabetes in Danish general practice...
November 9, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29119468/clinical-decision-support-and-optional-point-of-care-testing-of-renal-function-for-safe-use-of-antibiotics-in-elderly-patients-a-retrospective-study-in-community-pharmacy-practice
#6
Mette Heringa, Annemieke Floor-Schreudering, Peter A G M De Smet, Marcel L Bouvy
OBJECTIVE: The aim was to investigate the management of drug therapy alerts on safe use of antibiotics in elderly patients with (potential) renal impairment and the contribution of optional creatinine point of care testing (PoCT) in community pharmacy practice. METHODS: Community pharmacists used a clinical decision support system (CDSS) for seven antibiotics. Alerts were generated during prescription processing in the case of previously registered renal impairment and when no information on renal function was available for patients aged 70 and over...
November 8, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/29115397/detection-of-calprotectin-in-inflammatory-bowel-disease-fecal-and-serum-levels-and-immunohistochemical-localization
#7
Shuhei Fukunaga, Kotaro Kuwaki, Keiichi Mitsuyama, Hidetoshi Takedatsu, Shinichiro Yoshioka, Hiroshi Yamasaki, Ryosuke Yamauchi, Atsushi Mori, Tatsuyuki Kakuma, Osamu Tsuruta, Takuji Torimura
The aim of the present study was to quantify calprotectin levels using an enzyme-linked immunosorbent assay (ELISA) and a point-of-care test (POCT) in patients with inflammatory bowel disease. Overall, 113 patients with ulcerative colitis (UC; 51 men and 62 women) and 42 patients with Crohn's disease (CD; 29 men and 13 women), who were scheduled to undergo a colonoscopy, were prospectively enrolled and scored endoscopically and clinically. An additional 96 healthy, age-matched subjects served as the normal controls...
November 7, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29081959/1d-vs-2d-shape-selectivity-in-the-crystallization-driven-self-assembly-of-polylactide-block-copolymers
#8
Maria Inam, Graeme Cambridge, Anaïs Pitto-Barry, Zachary P L Laker, Neil R Wilson, Robert T Mathers, Andrew P Dove, Rachel K O'Reilly
2D materials such as graphene, LAPONITE® clays or molybdenum disulfide nanosheets are of extremely high interest to the materials community as a result of their high surface area and controllable surface properties. While several methods to access 2D inorganic materials are known, the investigation of 2D organic nanomaterials is less well developed on account of the lack of ready synthetic accessibility. Crystallization-driven self-assembly (CDSA) has become a powerful method to access a wide range of complex but precisely-defined nanostructures...
June 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29073517/quantitative-detection-of-exosomal-microrna-extracted-from-human-blood-based-on-surface-enhanced-raman-scattering
#9
Dandan Ma, Caixia Huang, Jing Zheng, Jianru Tang, Jishan Li, Jinfeng Yang, Ronghua Yang
Since the nature of the exosomal lipid bilayer can allow miRNAs to be protected from degradation by cellular RNAses in body fluids, exosomal microRNA (miRNA) has become an ideal source of non-invasive biomarkers for the early diagnosis and prognosis. In this paper, a new surface-enhanced Raman scattering (SERS) analysis strategy combining stable SERS reporter element and duplex-specific nuclease (DSN)-assisted signal amplification for quantitative detection of exosomal miRNA extracted from human blood is proposed...
October 11, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29068375/recent-progress-in-optical-biosensors-based-on-smartphone-platforms
#10
REVIEW
Zhaoxin Geng, Xiong Zhang, Zhiyuan Fan, Xiaoqing Lv, Yue Su, Hongda Chen
With a rapid improvement of smartphone hardware and software, especially complementary metal oxide semiconductor (CMOS) cameras, many optical biosensors based on smartphone platforms have been presented, which have pushed the development of the point-of-care testing (POCT). Imaging-based and spectrometry-based detection techniques have been widely explored via different approaches. Combined with the smartphone, imaging-based and spectrometry-based methods are currently used to investigate a wide range of molecular properties in chemical and biological science for biosensing and diagnostics...
October 25, 2017: Sensors
https://www.readbyqxmd.com/read/29059253/a-novel-electronic-algorithm-using-host-biomarker-point-of-care-tests-for-the-management-of-febrile-illnesses-in-tanzanian-children-e-poct-a-randomized-controlled-non-inferiority-trial
#11
RANDOMIZED CONTROLLED TRIAL
Kristina Keitel, Frank Kagoro, Josephine Samaka, John Masimba, Zamzam Said, Hosiana Temba, Tarsis Mlaganile, Willy Sangu, Clotilde Rambaud-Althaus, Alain Gervaix, Blaise Genton, Valérie D'Acremont
BACKGROUND: The management of childhood infections remains inadequate in resource-limited countries, resulting in high mortality and irrational use of antimicrobials. Current disease management tools, such as the Integrated Management of Childhood Illness (IMCI) algorithm, rely solely on clinical signs and have not made use of available point-of-care tests (POCTs) that can help to identify children with severe infections and children in need of antibiotic treatment. e-POCT is a novel electronic algorithm based on current evidence; it guides clinicians through the entire consultation and recommends treatment based on a few clinical signs and POCT results, some performed in all patients (malaria rapid diagnostic test, hemoglobin, oximeter) and others in selected subgroups only (C-reactive protein, procalcitonin, glucometer)...
October 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29027752/label-free-multiplex-dna-detection-utilizing-projected-capacitive-touchscreen
#12
Joon Young Lee, Byoung Yeon Won, Hyun Gyu Park
We have developed a novel strategy to achieve label-free multiplex DNA detection system based on the projected capacitive touchscreen. Touchscreen panel was first fabricated by patterning the ITO (indium-tin-oxide) electrode array on the glass wafer, and the electrodes were modified with the respective capture probe DNA sequences complementary to hemagglutinin1 (H1), neuraminidase1 (N1), and matrix1 (M1) DNA to demonstrate the molecular diagnosis of H1N1 influenza virus as a model pathogen. DNA sample was then applied to the electrodes to allow hybridization of target DNA with the corresponding complementary capture probe...
October 13, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/29016564/the-role-of-an-iga-igg-deamidated-gliadin-peptide-point-of-care-test-in-predicting-persistent-villous-atrophy-in-patients-with-celiac-disease-on-a-gluten-free-diet
#13
Michelle S Lau, Peter D Mooney, William L White, Michael A Rees, Simon H Wong, Matthew Kurien, Nick Trott, Daniel A Leffler, Marios Hadjivassiliou, David S Sanders
OBJECTIVES: Mucosal healing is important in celiac disease (CD) for the prevention of complications. However, obtaining duodenal biopsies is invasive, and there is currently no reliable surrogate marker for histological remission in clinical practice. We aimed to assess the role of a point-of-care test (POCT) based on IgA/IgG-deamidated gliadin peptide, in detecting persistent villous atrophy (VA) in CD. METHODS: We prospectively recruited patients with CD attending endoscopy for the assessment of histological remission...
October 10, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28988194/observational-study-of-the-populations-accessing-rapid-point-of-care-hiv-testing-in-winnipeg-manitoba-canada-through-a-retrospective-chart-review-of-site-records
#14
James Blain Johnston, Joss N Reimer, John L Wylie, Jared Bullard
OBJECTIVES: HIV point-of-care testing (POCT) has been available in Manitoba since 2008. This study evaluated the effectiveness of POCT at identifying individuals with previously unknown HIV status, its effects on clinical outcomes and the characteristics of the populations reached. METHODS: A retrospective database review was conducted for individuals who received HIV POCT from 2011 to 2014. Time to linkage to care and viral load suppression were compared between individuals who tested positive for HIV using POCT and controls identified as positive through standard screening...
October 7, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28985344/point-of-care-testing-in-primary-care-patients-with-acute-cardiopulmonary-symptoms-a-systematic-review
#15
Angel M R Schols, Jacqueline P G Stakenborg, Geert-Jan Dinant, Robert T A Willemsen, Jochen W L Cals
Background: Point-of-care tests (POCT) can assist general practitioners (GPs) in diagnosing and treating patients with acute cardiopulmonary symptoms, but it is currently unknown if POCT impact relevant clinical outcomes in these patients. Objective: To assess whether using POCT in primary care patients with acute cardiopulmonary symptoms leads to more accurate diagnosis and impacts clinical management. Methods: We performed a systematic review in four bibliographic databases...
July 23, 2017: Family Practice
https://www.readbyqxmd.com/read/28980671/gold-platinum-bimetallic-nanoclusters-with-enhanced-peroxidase-like-activity-and-their-integrated-agarose-hydrogel-based-sensing-platform-for-the-colorimetric-analysis-of-glucose-levels-in-serum
#16
Jiayu Feng, Pengcheng Huang, Fang-Ying Wu
This work presents a novel and facile strategy for the fabrication of gold-platinum bimetallic nanoclusters (Au-PtNCs) with adjustable Au/Pt molar ratios by a one-pot synthetic route. It was unexpectedly found that the prepared Au-PtNCs with an optimal Au/Pt molar ratio (1 : 1) could exhibit greatly enhanced peroxidase-like catalytic activity and chemical stability toward harsh conditions due to the synergistic effect of the two atoms, in contrast with pure AuNCs. These prominent advantages render Au-PtNCs capable of sensitive and selective colorimetric detection of glucose by means of a NCs-glucose oxidase (GOx) cascade-catalyzed system using 3,3',5,5'-tetramethylbenzidine (TMB) as a chromogenic substrate...
October 23, 2017: Analyst
https://www.readbyqxmd.com/read/28969667/general-practitioner-use-of-a-c-reactive-protein-point-of-care-test-to-help-target-antibiotic-prescribing-in-patients-with-acute-exacerbations-of-chronic-obstructive-pulmonary-disease-the-pace-study-study-protocol-for-a-randomised-controlled-trial
#17
Janine Bates, Nick A Francis, Patrick White, David Gillespie, Emma Thomas-Jones, Rachel Breen, Nigel Kirby, Kerry Hood, Micaela Gal, Rhiannon Phillips, Gurudutt Naik, Jochen Cals, Carl Llor, Hasse Melbye, Mandy Wootton, Evgenia Riga, Ann Cochrane, Robin Howe, Deborah Fitzsimmons, Bernadette Sewell, Mohammed Fasihul Alam, Christopher C Butler
BACKGROUND: Most patients presenting with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) in primary care are prescribed an antibiotic, which may not always be appropriate and may cause harm. C-reactive protein (CRP) is an acute-phase biomarker that can be rapidly measured at the point of care and may predict benefit from antibiotic treatment in AECOPD. It is not clear whether the addition of a CRP point-of-care test (POCT) to clinical assessment leads to a reduction in antibiotic consumption without having a negative impact on COPD health status...
September 29, 2017: Trials
https://www.readbyqxmd.com/read/28969328/viscoelastometry-guided-fresh-frozen-plasma-infusion-for-postpartum-haemorrhage-obs2-an-observational-study
#18
P W Collins, R Cannings-John, D Bruynseels, S Mallaiah, J Dick, C Elton, A Weeks, J Sanders, N Aawar, J Townson, K Hood, J Hall, K Harding, R Gauntlett, R Collis
Background: Postpartum haemorrhage (PPH) can be exacerbated by haemostatic failure. Based on data from trauma studies, empirical infusions of fresh frozen plasma (FFP) are often given during severe PPH if coagulation tests are unavailable. This study observed a cohort of women with moderate/severe PPH in whom FFP infusion was guided by the use of viscoelastometric point-of-care testing (VE-POCT) and clinical assessment. Methods: Women were enrolled into this observational study when blood loss was measured or suspected to be about 1000 mL...
September 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28968966/early-postoperative-radiotherapy-is-associated-with-improved-outcomes-over-late-postoperative-radiotherapy-in-the-management-of-completely-resected-r0-stage-iiia-n2-non-small-cell-lung-cancer
#19
Huan-Huan Wang, Lei Deng, Qing-Lian Wen, Chun-Ze Zhang, Nicholas G Zaorsky, Bai-Lin Zhang, Jie Chen, Xian-Liang Zeng, Yao-Li Cui, Yang-Yang Shi, Hai-Ling Hou, Wei Wang, Bo Jiang, Jun Wang, Qing-Song Pang, Lu-Jun Zhao, Zhi-Yong Yuan, Ping Wang, Mao-Bin Meng
AIMS: The aim of this study was to evaluate the ideal timing of PORT in the management of completely resected (R0) Stage IIIA-N2 NSCLC. PATIENTS AND METHODS: Between January 2008 and December 2015, patients with known histologies of pathologic Stage IIIA-N2 NSCLC who underwent R0 resection and received PORT concurrent with or prior to two sequential cycles of chemotherapy ("early PORT") or with PORT administered after two cycles of chemotherapy ("late PORT") at multiple hospitals...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28965053/point-of-care-testing-for-streptomycin-based-on-aptamer-recognizing-and-digital-image-colorimetry-by-smartphone
#20
Bixia Lin, Ying Yu, Yujuan Cao, Manli Guo, Debin Zhu, Jiaxing Dai, Minshi Zheng
The rapid detection of antibiotic residual in everyday life is very important for food safety. In order to realize the on-site and visual detection of antibiotic, a POCT method was established by using digital image colorimetry based on smartphone. Streptomycin was taken as the analyte model of antibiotics, streptomycin aptamer preferentially recognized analyte, and the excess aptamer hybridized with the complementary DNA to form the dsDNA. SYBR Green I combined with the dsDNA and then emitted obvious green fluorescence, thus the fluorescence intensity decreased with the increasing of streptomycin concentration...
September 20, 2017: Biosensors & Bioelectronics
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