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Meri Kankaanpää, Maria Raitakari, Leila Muukkonen, Siv Gustafsson, Merja Heitto, Ari Palomäki, Kimmo Suojanen, Veli-Pekka Harjola
BACKGROUND: To assess whether the use of point-of-care testing (POCT) and early assessment team (EAT) model shortens emergency department (ED) length of stay (LOS). METHODS: This prospective, observational study with comparison between three study periods was performed in three phases in a metropolitan ED with 57,000 annual visits. Data were collected from adult ambulatory patients who were discharged home. Phase 1 served as a control (n = 1559 in one month)...
October 18, 2016: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Doris Barcellona, Lara Fenu, Francesco Marongiu
Oral anticoagulant therapies with the anti-vitamin K drugs (AVK), warfarin, acenocoumarol and phenprocoumon, are employed in primary and secondary anti-thrombotic prophylaxis in patients with venous thromboembolism, atrial fibrillation and cardiac mechanical valves. However, a monitoring test such as the International Normalized Ratio (INR) is required. The periodic monitoring of this therapy entails discomfort for the patients. Telemedicine and telecare can provide significant aid in the management of this therapy allowing patients to perform the test at home or anywhere else with a portable device, i...
October 18, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
Ning Xia, Xin Wang, Lin Liu
Human chorionic gonadotropin (hCG) has been regarded as a biomarker for the diagnosis of pregnancy and some cancers. Because the currently used methods (e.g., disposable Point of Care Testing (POCT) device) for hCG detection require the use of many less stable antibodies, simple and cost-effective methods for the sensitive and selective detection of hCG have always been desired. In this work, we have developed a graphene oxide (GO)-based fluorescent platform for the detection of hCG using a fluorescein isothiocyanate (FITC)-labeled hCG-specific binding peptide aptamer (denoted as FITC-PPLRINRHILTR) as the probe, which can be manufactured cheaply and consistently...
October 13, 2016: Sensors
Hwan-Ik Kim, O Kyu Noh, Young-Taek Oh, Mison Chun, Sang-Won Kim, Oyeon Cho, Jaesung Heo
PURPOSE: Our institution has implemented two different adjuvant protocols in treating patients with non-small cell lung cancer (NSCLC): chemotherapy followed by concurrent chemoradiotherapy (CT-CCRT) and sequential postoperative radiotherapy (PORT) followed by postoperative chemotherapy (POCT). We aimed to compare the clinical outcomes between the two adjuvant protocols. MATERIALS AND METHODS: From March 1997 to October 2012, 68 patients were treated with CT-CCRT (n = 25) and sequential PORT followed by POCT (RT-CT; n = 43)...
September 2016: Radiation Oncology Journal
Penny Ford Carleton, Steven Schachter, John A Parrish, John M Collins, J Benjamin Crocker, Ronald F Dixon, Susan Edgman-Levitan, Kent B Lewandrowski, James E Stahl, Catherine Klapperich, Mario Cabodi, Charlotte A Gaydos, Anne M Rompalo, Yukari Manabe, Tza-Huei Wang, Richard Rothman, Chris D Geddes, Lea Widdice, Joany Jackman, Rishi A Mathura, Tiffani Bailey Lash
To advance the development of point-of-care technology (POCT), the National Institute of Biomedical Imaging and Bioengineering established the POCT Research Network (POCTRN), comprised of Centers that emphasize multidisciplinary partnerships and close facilitation to move technologies from an early stage of development into clinical testing and patient use. This paper describes the POCTRN and the three currently funded Centers as examples of academic-based organizations that support collaborations across disciplines, institutions, and geographic regions to successfully drive innovative solutions from concept to patient care...
2016: IEEE Journal of Translational Engineering in Health and Medicine
Chung-Lieh Hung, Ding-Kuo Chien, Shou-Chuan Shih, Wen-Han Chang
BACKGROUND: Accurate diagnosis of acute coronary syndrome (ACS) in a timely fashion is challenging in the elderly population, especially elderly women, who usually exhibit atypical clinical symptoms. A multiple cardiac biomarker (MCB) based approach has been shown to improve diagnostic efficacy of ACS. However, data in various age groups and sex differences remain largely unexplored. METHODS: Point-of-care testing (POCT) was performed on 290 patients (aged ≥18 years) who were admitted to the emergency department (ED) with symptoms of acute chest pain under suspicion of acute coronary syndrome (ACS)...
October 7, 2016: BMC Cardiovascular Disorders
Jeremy R Huddy, Sharon-Marie Weldon, Shvaita Ralhan, Tim Painter, George B Hanna, Roger Kneebone, Fernando Bello
OBJECTIVES: Public and patient engagement (PPE) is fundamental to healthcare research. To facilitate effective engagement in novel point-of-care tests (POCTs), the test and downstream consequences of the result need to be considered. Sequential simulation (SqS) is a tool to represent patient journeys and the effects of intervention at each and subsequent stages. This case study presents a process evaluation of SqS as a tool for PPE in the development of a volatile organic compound-based breath test POCT for the diagnosis of oesophagogastric (OG) cancer...
September 13, 2016: BMJ Open
Yoo Min Park, Yong Duk Han, Hyeong Jin Chun, Hyun C Yoon
We present a hand-held optical biosensing system utilizing a smartphone-embedded illumination sensor that is integrated with immunoblotting assay method. The smartphone-embedded illumination sensor is regarded as an alternative optical receiver that can replaces the conventional optical analysis apparatus because the illumination sensor can respond to the ambient light in a wide range of wavelengths, including visible and infrared. To demonstrate the biosensing applicability of our system employing the enzyme-mediated immunoblotting and accompanying light interference, various types of ambient light conditions including outdoor sunlight and indoor fluorescent were tested...
September 2, 2016: Biosensors & Bioelectronics
Tone Bukve, Anne Stavelin, Sverre Sandberg
BACKGROUND: Users of point-of-care testing (POCT) in Norway participate in a quality improvement system that includes education and guidance in safe laboratory management along with participation in external quality assurance schemes (EQAS).The aim of this study was to identify the effect on the analytical performance of POCT C-reactive protein (CRP), glucose, and hemoglobin (Hb) with the use of a quality improvement system over time and to identify which factors are associated with good performance...
September 2, 2016: Clinical Chemistry
Andreas Bietenbeck
BACKGROUND: In health care, exchange of data is becoming increasingly important. However, it is still unclear how to interpret measurements of the same parameter from diverse data sources. In clinical chemistry point-of-care testing (POCT), e.g. for blood glucose, complements the analytical spectrum of central laboratories. Available data from "central laboratory", "professional POCT" and "non-professional" blood glucose measurements can be used to realistically simulate errors in different environments...
2016: Studies in Health Technology and Informatics
Matthew Thompson, Bernhard Weigl, Annette Fitzpatrick, Nicole Ide
Current frameworks for evaluating diagnostic tests are constrained by a focus on diagnostic accuracy, and assume that all aspects of the testing process and test attributes are discrete and equally important. Determining the balance between the benefits and harms associated with new or existing tests has been overlooked. Yet, this is critically important information for stakeholders involved in developing, testing, and implementing tests. This is particularly important for point of care tests (POCTs) where tradeoffs exist between numerous aspects of the testing process and test attributes...
2016: IEEE Journal of Translational Engineering in Health and Medicine
Andreas Pfützner, Anke H Pfützner, Peter H Kann, Gunther Burgard
BACKGROUND: Intact proinsulin is a biomarker for pancreatic ß-cell dysfunction. In large prospective studies in nondiabetic subjects, elevated intact proinsulin predicted development of type 2 diabetes and/or macrovascular events up to 7 years in advance. This study was performed to evaluate a new semiquantitative lateral flow-based point-of-care rapid test (POCT) for elevated intact proinsulin (cutoff: 15 pmol/L). The test requires 10 µL of capillary whole blood, with visual readout after 5 minutes...
August 23, 2016: Journal of Diabetes Science and Technology
Huiping Wei, Fang Lan, Qitian He, Haiwei Li, Fuyong Zhang, Xue Qin, Shan Li
BACKGROUND: Diabetes mellitus is a metabolic disease that is characterized by hyperglycemia. Blood glucose (BG) is helpful for the diagnosis and treatment of diabetes and an important part of the management of diabetes. Point-of-care testing (POCT) is generally used by patients themselves or medical personnel to monitor BG. The objective of this article was to evaluate the accuracy and consistency of POCT on venous blood samples and compare it with the central laboratory system to determine the reliability of POCT measurement results as diagnostic criteria...
August 25, 2016: Journal of Clinical Laboratory Analysis
Go Sano, Tsutomu Itagaki, Naruhiko Ishiwada, Keita Matsubara, Satoshi Iwata, Yoshitaka Nakamori, Kenji Matsuyama, Katsuya Watanabe, Yoshikazu Ishii, Sakae Homma, Kazuhiro Tateda
Point-of-care testing (POCT) for Mycoplasma pneumoniae infection may be ideal and useful, because significant numbers of the cases will be seen as an outpatient. Recently, a new immune-chromatographic method (ICM) targeting M. pneumoniae ribosomal protein L7/L12 (RP-L7/L12) became available in Japan, although clinical data and basic information regarding efficacy and characterization of this ICM are limited. The present study examined the fate of M. pneumoniae ribosomal protein L7/L12 (RP-L7/L12) during the growth in-vitro and correlation between M...
August 19, 2016: Journal of Medical Microbiology
Stephen C Davies, Andrew Koh, Heather E Lindsay, Richard B Fulton, Suran L Fernando
An inner Sydney sexual health service introduced the option to gay and bisexual men of receiving a negative HIV result by SMS to mobile phone one business day after venipuncture (rapid SMS). Men could also choose one of the other options: a point-of-care-test (POCT), by phone, or in-person (clinicians could also require in-person). We followed-up patients choosing the rapid SMS method to ascertain their satisfaction. During 12 months, 473 men had 591 HIV tests. Of these tests, 5.4% were POCTs, 9.1% were in-person, 24% were by phone, and 62% were rapid SMS...
August 18, 2016: International Journal of STD & AIDS
Gea A Holtman, Yvonne Lisman-van Leeuwen, Patrick F van Rheenen, Boudewijn J Kollen, Johanna C Escher, Angelika Kindermann, Yolanda B de Rijke, Marjolein Y Berger
BACKGROUND: Faecal calprotectin is considered to be a valid test for ruling out inflammatory bowel disease (IBD) in children with chronic gastrointestinal symptoms in specialist care. In contrast, faecal lactoferrin has higher specificity. The recent availability of both as point-of-care tests (POCTs) makes them attractive for use in primary care. OBJECTIVE: To evaluate the test characteristics of calprotectin and lactoferrin POCTs for diagnosing IBD in symptomatic children...
August 17, 2016: Family Practice
Biao Ma, Yi-Zhen Song, Ji-Cheng Niu, Zhi-Yong Wu
We present a novel electrokinetic stacking (ES) method based on field amplification on a simple paper device for sample preconcentration. With voltage application, charged probe ions in a solution of lower conductivity stack and form a narrow band at the boundary between the sample and the background electrolyte of higher conductivity. The stacking band appears quickly and stabilizes in a few minutes. With this ES method, three orders of magnitude signal improvement was successfully achieved for both a fluorescein probe and a double-stranded DNA within 300 s...
September 21, 2016: Lab on a Chip
Mika Hatada, Wakako Tsugawa, Eri Kamio, Noya Loew, David C Klonoff, Koji Sode
Glycated proteins, such as glycated hemoglobin (HbA1c) or glycated albumin (GA) in the blood, are essential indicators of glycemic control for diabetes mellitus. Since GA, compared to HbA1c, is more sensitive to short term changes in glycemic levels, GA is expected to be used as an alternative or together with HbA1c as a surrogate marker indicator for glycemic control. In this paper we report the development of a sensing system for measuring GA by combining an enzyme analysis method, which is already used in clinical practice, with electrochemical principles...
August 3, 2016: Biosensors & Bioelectronics
Sanne van Delft, Annelijn Goedhart, Mark Spigt, Bart van Pinxteren, Niek de Wit, Rogier Hopstaken
OBJECTIVE: Point-of-care testing (POCT) urinalysis might reduce errors in (subjective) reading, registration and communication of test results, and might also improve diagnostic outcome and optimise patient management. Evidence is lacking. In the present study, we have studied the analytical performance of automated urinalysis and visual urinalysis compared with a reference standard in routine general practice. SETTING: The study was performed in six general practitioner (GP) group practices in the Netherlands...
2016: BMJ Open
Lucyna Kepka, Joanna Socha, Monika Rucinska, Ewa Wasilewska-Tesluk, Katarzyna Komosinska
This editorial comments on the study by Lee et al. which reported on the use of postoperative radiotherapy (PORT) as first strategy after resection of stage IIIA-pN2 non-small cell lung cancer (NSCLC). After completion of PORT, 41% of patients received postoperative chemotherapy (POCT). The five-year overall survival (OS) was significantly higher in patients treated with PORT and POCT than in patients treated with PORT alone. Authors concluded that PORT used as first postoperative strategy does not compromise a benefit of POCT and its implementation should be further studied...
July 2016: Journal of Thoracic Disease
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