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https://www.readbyqxmd.com/read/28102586/creatinine-in-urine-a-method-comparison
#1
Marc Luginbühl, Wolfgang Weinmann
Drug screening in urine is widely applied in forensic toxicology. Contrary to blood analysis, excessive or reduced fluid intake can substantially alter the concentration of substances in urine. As a standard to detect urinary dilution, creatinine concentrations are analyzed. A sample with a concentration below 20 mg/dL is generally defined as too diluted to provide a valid result in abstinence control samples. This work investigates the potential of three different methods for the determination of creatinine concentrations in urine samples: A ZIC-HILIC based LC-MS/MS method, a spectrophotometric method on an AU 480 chemistry system, and a portable, immunoassay based point-of-care testing device was compared by measuring 200 urine samples...
January 19, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28040285/diagnostic-performance-of-a-high-sensitive-troponin-t-assay-and-a-troponin-t-point-of-care-assay-in-the-clinical-routine-of-an-emergency-department-a-clinical-cohort-study
#2
Anna Slagman, Johannes von Recum, Martin Möckel, Fabian Holert, Dirk Meyer Zum Büschenfelde, Christian Müller, Julia Searle
BACKGROUND: A point of care test (POCT) for troponin T (TnT) in the Emergency Department (ED) was compared to a high-sensitivity TnT (hsTnT) central laboratory test (CLT) to determine the influence of test system and different cut-off values on the diagnostic performance in patients with suspected acute coronary syndrome (ACS) under routine conditions. METHODS: All patients with routine TnT testing in the ED were enrolled. Only internal medicine patients without STEMI and with both troponin values were analyzed...
December 21, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27997479/potential-for-pharmacy-public-health-collaborations-using-pharmacy-based-point-of-care-testing-services-for-infectious-diseases
#3
Paul O Gubbins, Michael E Klepser, Alex J Adams, David M Jacobs, Kelly M Percival, Gregory B Tallman
CONTEXT: Health care professionals must continually identify collaborative ways to combat antibiotic resistance while improving community health and health care delivery. Clinical Laboratory Improvement Amendments of 1988 (CLIA)-waived point-of-care (POC) testing (POCT) services for infectious disease conducted in community pharmacies provide a means for pharmacists to collaborate with prescribers and/or public health officials combating antibiotic resistance while improving community health and health care delivery...
December 16, 2016: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/27995270/schnelltest-diagnostik-sexuell-%C3%A3-bertragbarer-infektionen-in-niedrigschwelligen-einrichtungen-gemeinsame-stellungnahme-des-rki-pei-und-der-dstig
#4
Thomas Meyer, Christian G Schüttler, Eberhard Straube, R Stefan Roß, Martin Stürmer, Klaus Jansen, Susanne Buder, Sigrid Nick, Hans-Jochen Hagedorn, Viviane Bremer, Norbert H Brockmeyer
On February 5th, 2016 an expert meeting on rapid diagnostic tests (RDT) for sexually transmitted infections (STI) was held in Berlin at the Robert-Koch-Institute. The aim of the conference was to update a former evaluation of RDTs for diagnosis of HIV, HBV, HCV, T. pallidum, C. trachomatis and N. gonorrhoeae in low-threshold counseling services for STI that had been published after the previous meeting in 2012. According to the strategy to control HIV, hepatitis B and C and other STI, recently adopted by the German Government, there is a lack of test capabilities and a demand for more testing services as well as improved access to testing...
December 19, 2016: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/27960145/visualized-detection-of-single-base-difference-in-multiplexed-loop-mediated-isothermal-amplification-amplicons-by-invasive-reaction-coupled-with-oligonucleotide-probe-modified-gold-nanoparticles
#5
Yan Lu, Xueping Ma, Jianping Wang, Nan Sheng, Tianhui Dong, Qinxin Song, Jianzhong Rui, Bingjie Zou, Guohua Zhou
Loop-mediated isothermal amplification (LAMP) is a well-developed DNA amplification method with an ultra-high sensitivity, but it is difficult to recognize a single-base difference (like genotyping) in target-specific amplicons by conventional detection ways, such as the intercalation of dyes into dsDNA amplicons or the increase of solution turbidity along with the polymerization process. To allow genotyping based on LAMP suitable for POCT (point-of-care testing) or on-site testing, here we proposed a highly specific and cost-effective method for detecting a single-base difference in LAMP amplicons...
April 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27957766/evaluation-of-a-novel-point-of-care-test-kit-absogen-%C3%A2-pct-in-semi-quantitative-measurement-of-procalcitonin-in-whole-blood
#6
Hi Jeong Kwon, Jehoon Lee, Hae-Il Park, Kyungja Han
BACKGROUND: In response to inflammation, procalcitonin plasma concentrations increase more rapidly than other acute-phase reactants and higher values are associated with severe disease. Procalcitonin measurements assist in determining whether antibiotic therapy should be used. point-of-care testing (POCT) is performed for early decision making about additional testing or therapy. The ABSOGEN(™) PCT (Bumyoungbio, Inc., Suwon, Korea) is a rapid novel semi-quantitative immunochromatographic PCT assay that analyses whole blood samples...
December 13, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27922750/pre-implementation-guidelines-for-infectious-disease-point-of-care-testing-in-medical-institutions
#7
Annemiek A van der Eijk, Andrei N Tintu, John P Hays
Infectious disease point-of-care test (ID-POCT) devices are becoming widely available, and in this respect, international quality standards and guidelines are available for consultation once ID-POCT has been implemented into medical institutions. However, specific guidelines for consultation during the initial pre-implementation decision-making process are currently lacking. Further, there exist pre-implementation issues specific to ID-POCT. Here we present pre-implementation guidelines for consultation when considering the implementation of ID-POCT in medical institutions...
January 2017: Future Microbiology
https://www.readbyqxmd.com/read/27920568/reduced-butyrylcholinesterase-activity-is-an-early-indicator-of-trauma-induced-acute-systemic-inflammatory-response
#8
Aleksandar R Zivkovic, Jochen Bender, Thorsten Brenner, Stefan Hofer, Karsten Schmidt
PURPOSE: Early diagnosis of systemic inflammatory response syndrome is fundamentally important for an effective and a goal-directed therapy. Various inflammation biomarkers have been used in clinical and experimental practice. However, a definitive diagnostic tool for an early detection of systemic inflammation remains to be identified. Acetylcholine (Ach) has been shown to play an important role in the inflammatory response. Serum cholinesterase (butyrylcholinesterase [BChE]) is the major Ach hydrolyzing enzyme in blood...
2016: Journal of Inflammation Research
https://www.readbyqxmd.com/read/27911908/uptake-of-community-based-peer-administered-hiv-point-of-care-testing-findings-from-the-proud-study
#9
Lisa Lazarus, Sheetal Patel, Ashley Shaw, Sean Leblanc, Christine Lalonde, Manisha Hladio, Kira Mandryk, Cynthia Horvath, William Petrcich, Claire Kendall, Mark W Tyndall
OBJECTIVES: HIV prevalence among people who inject drugs (PWID) in Ottawa is estimated at about 10%. The successful integration of peers into outreach efforts and wider access to HIV point-of-care testing (POCT) create opportunities to explore the role of peers in providing HIV testing. The PROUD study, in partnership with Ottawa Public Health (OPH), sought to develop a model for community-based peer-administered HIV POCT. METHODS: PROUD draws on community-based participatory research methods to better understand the HIV risk environment of people who use drugs in Ottawa...
2016: PloS One
https://www.readbyqxmd.com/read/27906513/smartphone-based-portable-wireless-optical-system-for-the-detection-of-target-analytes
#10
Shreedhar Gautam, Bhagwan S Batule, Hyo Yong Kim, Ki Soo Park, Hyun Gyu Park
Rapid and accurate on-site wireless measurement of hazardous molecules or biomarkers is one of the biggest challenges in nanobiotechnology. A novel smartphone-based Portable and Wireless Optical System (PAWS) for rapid, quantitative, and on-site analysis of target analytes is described. As a proof-of-concept, we employed gold nanoparticles (GNP) and an enzyme, horse radish peroxidase (HRP), to generate colorimetric signals in response to two model target molecules, melamine and hydrogen peroxide, respectively...
December 1, 2016: Biotechnology Journal
https://www.readbyqxmd.com/read/27900430/visible-and-red-emissive-molecular-beacons-for-optical-temperature-measurements-and-quality-control-in-diagnostic-assays-utilizing-temperature-dependent-amplification-reactions
#11
Zerrin Fidan, Andy Wende, Ute Resch-Genger
Quality control requirements imposed on assays used in clinical diagnostics and point-of-care-diagnostic testing (POCT), utilizing amplification reactions performed at elevated temperatures of 35 to 95 °C are very stringent. As the temperature of a reaction vessel has a large impact on the specificity and sensitivity of the amplification reaction, simple tools for local in situ temperature sensing and monitoring are required for reaction and assay control. We describe here a platform of stem-and-loop structured DNA hairpins (molecular beacons, MBs), absorbing and emitting in the visible and red spectral region, rationally designed for precise temperature measurements in microfluidic assays for POCT, and their application for temperature measurements in a common DNA-based molecular biological assay utilizing thermophilic helicase-dependent amplification (tHDA)...
November 29, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27899825/the-role-of-pharmacists-and-pharmacy-education-in-point-of-care-testing
#12
James P Kehrer, Deborah E James
Point-of-care testing (POCT) is defined as laboratory testing conducted close to the site of patient care. Although performed originally primarily by clinical staff for acute conditions, recent advances in technology have made such testing possible for disease screening and prevention across a wide range of conditions in virtually any setting, and often by individuals with little or no training. With the ongoing evolution in POCT, numerous concerns have arisen about the quality and accuracy of the tests, comparability between multiple tests for the same endpoint, interpretation of test results, and whether and how results should be used for therapeutic decisions and included in a patient's medical record...
October 25, 2016: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/27880783/comparability-of-point-of-care-versus-central-laboratory-hemoglobin-determination-in-emergency-patients-at-a-supra-maximal-care-hospital
#13
Ramona C Dolscheid-Pommerich, Sarah Dolscheid, Daniel Grigutsch, Birgit Stoffel-Wagner, Ingo Graeff
Fulfilling the requirements of point-of-care testing (POCT) training regarding proper execution of measurements and compliance with internal and external quality control specifications is a great challenge. Our aim was to compare the values of the highly critical parameter hemoglobin (Hb) determined with POCT devices and central laboratory analyzer in the highly vulnerable setting of an emergency department in a supra maximal care hospital to assess the quality of POCT performance. In 2548 patients, Hb measurements using POCT devices (POCT-Hb) were compared with Hb measurements performed at the central laboratory (Hb-ZL)...
2016: PloS One
https://www.readbyqxmd.com/read/27832552/current-limitations-of-the-assessment-of-haemostasis-in-adult-extracorporeal-membrane-oxygenation-patients-and-the-role-of-point-of-care-testing
#14
K Venkatesh, P S Nair, D J Hoechter, H Buscher
Haemostatic perturbations are commonly seen in extracorporeal membrane oxygenation (ECMO) patients and remain a clinical challenge, contributing significantly to morbidity and mortality. The approach to anticoagulation monitoring and the management of bleeding varies considerably across ECMO centres. Routine laboratory tests have their limitations in terms of turnaround time and specificity of information provided. Newer point-of-care testing (POCT) for coagulation may overcome these issues, as it provides information about the entire coagulation pathway from clot initiation to lysis...
November 2016: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/27827837/machine-learning-based-single-frame-super-resolution-processing-for-lensless-blood-cell-counting
#15
Xiwei Huang, Yu Jiang, Xu Liu, Hang Xu, Zhi Han, Hailong Rong, Haiping Yang, Mei Yan, Hao Yu
A lensless blood cell counting system integrating microfluidic channel and a complementary metal oxide semiconductor (CMOS) image sensor is a promising technique to miniaturize the conventional optical lens based imaging system for point-of-care testing (POCT). However, such a system has limited resolution, making it imperative to improve resolution from the system-level using super-resolution (SR) processing. Yet, how to improve resolution towards better cell detection and recognition with low cost of processing resources and without degrading system throughput is still a challenge...
November 2, 2016: Sensors
https://www.readbyqxmd.com/read/27818213/co-creation-of-market-expansion-in-point-of-care-testing-in-the-united-states-industry-leadership-perspectives-on-the-community-pharmacy-segment
#16
Kenneth C Hohmeier, Sharon L K McDonough, Junling Wang
BACKGROUND: Point-of-care testing (POCT) is a specialty of laboratory medicine that occurs at the bedside or near the patient when receiving health services. Despite its established clinical utility and consumer demand in the community pharmacy, the implementation of POCT within this setting has remained modest for a variety of reasons. One possible solution to this problem is the concept of co-creation - the partnership between consumer and manufacturer in the development of value for a service or device...
October 27, 2016: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/27809865/exploring-the-barriers-and-facilitators-to-use-of-point-of-care-tests-in-family-medicine-clinics-in-the-united-states
#17
Victoria Hardy, Matthew Thompson, William Alto, Gina A Keppel, Jaime Hornecker, Adriana Linares, Beth Robitaille, Laura-Mae Baldwin
BACKGROUND: Point-of-care tests (POCTs) are increasingly used in family medicine clinics in the United States. While the diagnostics industry predicts significant growth in the number and scope of POCTs deployed, little is known about clinic-level attitudes towards implementation of these tests. We aimed to explore attitudes of primary care providers, laboratory and clinic administrative/support staff to identify barriers and facilitators to use of POCTs in family medicine. METHODS: Seven focus groups and four semi-structured interviews were conducted with a total of 52 clinic staff from three family medicine clinics in two US states...
November 3, 2016: BMC Family Practice
https://www.readbyqxmd.com/read/27785483/a-shake-read-distance-based-microfluidic-chip-as-a-portable-quantitative-readout-device-for-highly-sensitive-point-of-care-testing
#18
Yi Xie, Xiaofeng Wei, Qizhen Yang, Zhichao Guan, Dan Liu, Xuan Liu, Leiji Zhou, Zhi Zhu, Zhenyu Lin, Chaoyong Yang
Despite the rapid development of point-of-care testing (POCT) devices in recent years, quantitative POCT is still not readily available. Herein, we developed a simple, disposable and equipment-free quantitative POCT platform, the Shake&Read distance-based microfluidic Chip (S&R-μChip), for visual quantitative POCT and demonstrated its use in Enzyme-Linked Immunosorbent Assay (ELISA) for the detection of disease biomarkers.
October 27, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27785064/the-influence-of-the-metastasis-pattern-of-mediastinal-lymph-nodes-on-the-postoperative-radiotherapy-s-efficacy-for-the-iiia-pn2-non-small-cell-lung-cancer-a-retrospective-analysis-of-220-patients
#19
Baozhong Zhang, Lujun Zhao, Zhiyong Yuan, Qingsong Pang, Ping Wang
OBJECTIVE: The use of postoperative radiotherapy (PORT) remains controversial for Stage IIIA-N2 non-small-cell lung cancer (NSCLC) patients, a possible reason is that IIIA-pN2 NSCLC diseases are a heterogeneous group with different clinicopathologic features. The aim of this research was to prove whether the mediastinal lymph nodes' (LNs) skipping status could indicate the necessity of the PORT for the pN2 NSCLC patients. METHODS: The skip metastasis was defined as pN0N2 (no N1 LN involved), and nonskip metastasis was pN1N2 (one or more N1 LNs involved)...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27784465/-patterns-of-recurrence-in-patients-with-stage-pt2-n0-1m0-esophageal-squamous-cell-carcinoma-after-radical-resection
#20
Y X Wang, Y H Gao, J Li, R Qiu, X Y Qiao
Objective: To retrospectively investigate the patterns of recurrence and its related factors in patients with stage pT2N0-1M0 thoracic esophageal squamous cell carcinoma (ESCC) after radical resection. Methods: Two hundred and twenty-two cases of stage pT2N0-1M0 thoracic ESCC treated in our hospital from 2008 to 2011 were enrolled. There were 142 males and 80 females. There were 181 cases in stage pN1 and 41 cases in stage pN1. 142 patients were treated with surgery alone and 80 with adjuvant postoperative chemotherapy (POCT)...
October 23, 2016: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
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