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https://www.readbyqxmd.com/read/28542080/manuscript-title-multidisciplinary-point-of-care-testing-in-south-african-primary-healthcare-clinics-accelerates-hiv-art-initiation-but-does-not-alter-retention-in-care
#1
Wendy S Stevens, Natasha M Gous, William B MacLeod, Lawrence C Long, Ebrahim Variava, Neil A Martinson, Ian Sanne, Regina Osih, Lesley E Scott
BACKGROUND: Lack of accessible laboratory infrastructure limits HIV antiretroviral (ART) treatment initiation, monitoring and retention in many resource-limited settings. Point-of-care testing (POCT) is advocated as a mechanism to overcome these limitations. We executed a pragmatic, prospective, randomized, controlled trial comparing the impact of POCT versus standard-of-care (SOC) on treatment initiation and retention in care. METHOD: Selected POC technologies were embedded at 3 primary health clinics in South Africa...
May 23, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28525851/a-fully-integrated-distance-readout-elisa-chip-for-point-of-care-testing-with-sample-in-answer-out-capability
#2
Dan Liu, Xingrui Li, Junkai Zhou, Shibo Liu, Tian Tian, Yanling Song, Zhi Zhu, Leiji Zhou, Tianhai Ji, Chaoyong Yang
Enzyme-linked immunosorbent assay (ELISA) is a popular laboratory technique for detection of disease-specific protein biomarkers with high specificity and sensitivity. However, ELISA requires labor-intensive and time-consuming procedures with skilled operators and spectroscopic instrumentation. Simplification of the procedures and miniaturization of the devices are crucial for ELISA-based point-of-care (POC) testing in resource-limited settings. Here, we present a fully integrated, instrument-free, low-cost and portable POC platform which integrates the process of ELISA and the distance readout into a single microfluidic chip...
May 4, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28511553/whole-blood-platelet-aggregation-test-and-prediction-of-hemostatic-difficulty-after-tooth-extraction-in-patients-receiving-antiplatelet-therapy
#3
Yasushi Nagao, Rikuo Masuda, Akane Ando, Mutsumi Nonaka, Akiko Nishimura, Kinuko Goto, Yasubumi Maruoka, Takehiko Iijima
When patients on antiplatelet therapy (APT) require minor invasive surgery, APT is usually continued to limit the risk of thrombosis. However, the possibility of hemostatic difficulties necessitates the monitoring of platelet aggregation to prevent unexpected bleeding. We examined whether whole blood aggregometry as a point-of-care testing (POCT) could be useful as a tool for predicting hemostatic difficulties. Sixty-five patients receiving APT and 15 patients who were not receiving APT were enrolled in the present study; all patients were scheduled to undergo a tooth extraction...
January 1, 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/28491862/comparison-of-fecal-calprotectin-methods-for-predicting-relapse-of-pediatric-inflammatory-bowel-disease
#4
Saranya Kittanakom, Md Sharif Shajib, Kristine Garvie, Joceline Turner, Dan Brooks, Sufian Odeh, Robert Issenman, V Tony Chetty, Joseph Macri, Waliul I Khan
Background. Pediatric inflammatory bowel disease (IBD) is on the rise worldwide. Endoscopies are necessary for IBD assessment but are invasive, expensive, and inconvenient. Recently, fecal calprotectin (FCal) was proposed as a noninvasive and specific marker of gut inflammation. We evaluated the analytical performance of three FCal assays and their clinical performance in predicting relapse in pediatric IBD. Methods. This study used 40 pediatric IBD and 40 random non-IBD patients' fecal samples. Two automated ELISAs (Bühlmann and PhiCal® Calprotectin-EIA) and an EliA (Phadia 250 EliA-Calprotectin) were used to evaluate the analytical performance...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28460169/bioorthogonal-reaction-mediated-elisa-using-peroxide-test-strip-as-signal-readout-for-point-of-care-testing
#5
Bei Ran, Yunlei Xianyu, Mingling Dong, Yiping Chen, Zhiyong Qian, Xingyu Jiang
This work demonstrates a highly sensitive peroxide test strip (PTS)-based enzyme-linked immunosorbent assay (ELISA) for both qualitative and quantitative detection of drugs of abuse (morphine) and disease biomarkers (interleukin-6 and HIV-1 capsid antigen p24). This color-based PTS is a commercially available product with advantages of low cost, easy operation, and portability, and it is an ideal signal readout strategy in ELISA to simplify the immunoassay procedures and enable point-of-care testing (POCT)...
May 10, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28459048/hiv-point-of-care-testing-in-canadian-settings-a-scoping-review
#6
REVIEW
Alexa Minichiello, Michelle Swab, Meck Chongo, Zack Marshall, Jacqueline Gahagan, Allison Maybank, Aurélie Hot, Michael Schwandt, Sonia Gaudry, Oliver Hurley, Shabnam Asghari
BACKGROUND: HIV point-of-care testing (POCT) was approved for use in Canada in 2005 and provides important public health benefits by providing rapid screening results rather than sending a blood sample to a laboratory and waiting on test results. Access to test results soon after testing (or during the same visit) is believed to increase the likelihood that individuals will receive their results and improve access to confirmatory testing and linkages to care. This paper reviews the literature on the utilization of HIV POCT across Canadian provinces...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28457907/consumer-perceptions-of-and-willingness-to-pay-for-point-of-care-testing-services-in-the-community-pharmacy
#7
Kenneth C Hohmeier, Benjamin Loomis, Justin Gatwood
BACKGROUND: Point-of-care testing (POCT) is a specialty of laboratory medicine that occurs at the bedside or near the patient when receiving health services. Despite its clinical utility, POCT implementation in the community pharmacy setting is slow due to uncertainty about the market for this novel service and remuneration for services rendered. OBJECTIVE: To identify 1) demographics and 2) willingness-to-pay preferences of the market niche of consumers who prefer to receive POCT services in the community pharmacy...
April 26, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/28444425/pharmacogenetic-markers-to-predict-the-clinical-response-to-methotrexate-in-south-indian-tamil-patients-with-psoriasis
#8
S Indhumathi, Medha Rajappa, Laxmisha Chandrashekar, P H Ananthanarayanan, D M Thappa, V S Negi
INTRODUCTION: Despite the advent of several new systemic therapies, methotrexate remains the gold standard for the treatment of moderate to severe psoriasis. However, there exists a significant heterogeneity in individual response to methotrexate. There are no consistently reliable markers to predict methotrexate treatment response till date. OBJECTIVES: We aimed to demonstrate the association of certain genetic variants in the HLA (HLA-A2, HLA-B17, and HLA-Cw6) and the non-HLA genes including T-helper (Th)-1, Th-2, Th-17 cytokine genes (IFN-γ, IL-2, IL-4, IL-10, IL-12B, and IL-23R), and T-regulatory gene (FOXP3) with the methotrexate treatment response in South Indian Tamil patients with psoriasis...
April 25, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28431640/rapid-assessment-of-drugs-of-abuse
#9
Joesph R Wiencek, Jennifer M Colby, James H Nichols
Laboratory testing for drugs of abuse has become standard practice in many settings both forensic and clinical. Urine is the predominant specimen, but other specimens are possible including hair, nails, sweat, and oral fluid. Point-of-care test kits provide for rapid analysis at the site where specimens are collected allowing for immediate action on the results. POCT is based on immunochromatography where the drug in the patient's sample competes with drug and antibody conjugates in the test to develop or block the development of a colored line...
2017: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/28421743/double-enzymes-mediated-bioluminescent-sensor-for-quantitative-and-ultrasensitive-point-of-care-testing
#10
Yiping Chen, Yunlei Xianyu, Jing Wu, Mingling Dong, Wenshu Zheng, Jiashu Sun, Xingyu Jiang
We report an ultrasensitive, quantitative, and rapid bioluminescent immunosensor (ABS) for point-of-care testing (POCT) of the disease biomarker in clinical samples using double enzymes including alkaline phosphatase (ALP) and luciferase. In the presence of the biomarker, the ALP attached on the surface of immuno-nanocomplex dephosphorylates adenine triphosphate (ATP), subsequently inhibiting the ATP-luciferin-luciferase bioluminescent reaction. The highly sensitive response of ATP (picomolar level) allows for ultrasensitive detection of biomarker via the effective change of the bioluminescence intensity through ALP- and luciferase-catalyzed reactions, which can be quantitatively determined by a portable ATP detector...
April 28, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28412662/a-wireless-point-of-care-testing-system-for-the-detection-of-neuron-specific-enolase-with-microfluidic-paper-based-analytical-devices
#11
Yan Fan, Juntao Liu, Yang Wang, Jinping Luo, Huiren Xu, Shengwei Xu, Xinxia Cai
Neuron-specific enolase (NSE) had clinical significance on diagnosis, staging, monitoring effect and judging prognosis of small cell lung cancer. Thus, there had a growing demand for the on-site testing of NSE. Here, a wireless point-of-care testing (POCT) system with electrochemical measurement for NSE detection was developed and verified. The wireless POCT system consisted of microfluidic paper-based analytical devices (μPADs), electrochemical detector and Android's smartphone. Differential pulse voltammetry (DPV) measurement was adopted by means of electrochemical detector which including a potentiostat and current-to-voltage converter...
September 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28392741/policies-and-practices-in-haemostasis-testing-among-laboratories-in-croatia-a-survey-on-behalf-of-a-working-group-for-laboratory-coagulation-of-the-croatian-society-of-medical-biochemistry-and-laboratory-medicine
#12
Ana Bronić, Desiree Coen Herak, Sandra Margetić, Marija Milić
INTRODUCTION: The objective of this survey was to assess current policies and practice in haemostasis testing among both hospital and outpatient laboratories in Republic of Croatia. MATERIALS AND METHODS: A questionnaire with seventy questions divided into nine sections was created in May 2015. Participants were asked about their practice related to test request form, sample collection, prothrombin time (PT) and activated partial thromboplastin time assays, other individual haemostasis assays, point-of-care testing (POCT), reporting of coagulation tests results and quality assurance of procedures, the personnel and other laboratory resources, as well as on issues related to education and implementation of additional coagulation assays in their laboratory...
February 15, 2017: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/28392237/routine-molecular-point-of-care-testing-for-respiratory-viruses-in-adults-presenting-to-hospital-with-acute-respiratory-illness-respoc-a-pragmatic-open-label-randomised-controlled-trial
#13
Nathan J Brendish, Ahalya K Malachira, Lawrence Armstrong, Rebecca Houghton, Sandra Aitken, Esther Nyimbili, Sean Ewings, Patrick J Lillie, Tristan W Clark
BACKGROUND: Respiratory virus infection is a common cause of hospitalisation in adults. Rapid point-of-care testing (POCT) for respiratory viruses might improve clinical care by reducing unnecessary antibiotic use, shortening length of hospital stay, improving influenza detection and treatment, and rationalising isolation facility use; however, insufficient evidence exists to support its use over standard clinical care. We aimed to assess the effect of routine POCT on a broad range of clinical outcomes including antibiotic use...
May 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28381047/motion-correction-using-overlapped-data-correlation-based-on-a-spatial-spectral-encoded-parallel-optical-coherence-tomography
#14
Zhiyan Chen, Yi Shen, Wen Bao, Peng Li, Xiaoping Wang, Zhihua Ding
This paper presents an approach to remove motion artifacts based on a spatial-spectral encoded parallel OCT (SSE-POCT) system, where encoded rectangular illumination is employed. Motion artifacts within a B-scan are avoided due to parallel detection intrinsic to parallel OCT, while those between successive B-scans are estimated and corrected by a proposed overlapped data correlation (ODC) algorithm. To preserve axial resolution, decoded B-scan corresponding to complete spectrum is stitched from successive encoded B-scans after motion correction...
March 20, 2017: Optics Express
https://www.readbyqxmd.com/read/28377153/clinical-performance-of-cardiac-troponin-i-a-comparison-between-the-poct-aqt90-flex-and-the-dimension-vista-analyzer-in-an-emergency-setting
#15
Monica Maria Mion, Giada Bragato, Alessandra Casarotti, Chiara Cosma, Stefania Vigolo, Gianna Vettore, Franco Tosato, Martina Zaninotto, Mario Plebani
BACKGROUND: Cardiac troponin [cTn (I or T)] is the preferred biomarker for the diagnosis of myocardial infarction (MI). AIM: We studied the analytical performance of the POCT AQT90 FLEX cTnI assay and its diagnostic accuracy, in comparison to the Dimension Vista cTnI method, in patients presenting to the Emergency Department (ED) with suspect of acute coronary syndrome (ACS). METHODS: 786 consecutive patients were enrolled. cTnI was measured at admission to the ED and about 3 and 6 hours later...
April 1, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28374509/point-of-care-tests-for-infectious-diseases-barriers-to-implementation-across-three-london-teaching-hospitals
#16
Amaya L Bustinduy, Dakshika Jeyaratnam, Sam Douthwaite, Sarah Tonkin-Crine, Rebecca Shaw, Laura Hyrapetian, Nick Sevdalis, Simon Goldenberg, Elisabeth J Adams, Mike Sharland
No abstract text is available yet for this article.
April 4, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28371852/improvement-in-the-quality-of-hba1c-determination-by-using-commutable-specimens-with-ifcc-assigned-values
#17
Rui Zhou, Zhi-Qi Gao, Qing Tong, Chang Zuo, Zhi-Xin Song, Wei Wang, Qing-Tao Wang
Background: To assess the usefulness of commutable secondary reference materials with International Federation of Clinical Chemistry (IFCC)-assigned values, for improving the quality of hemoglobin A1c (HbA 1c ) determination. Methods: We recalibrated and evaluated 3 point-of-care-test (POCT) devices via 3 different method-specific central laboratory analyzers that were calibrated using commutable specimens with IFCC-assigned values. The staff members who performed POCT were also evaluated before and after training...
May 1, 2017: Laboratory Medicine
https://www.readbyqxmd.com/read/28369370/diagnostic-performance-and-clinical-feasibility-of-a-point-of-care-test-for-respiratory-viral-infections-in-primary-health-care
#18
Andrea H L Bruning, Wilhelmina B de Kruijf, Henk C P M van Weert, Wim L M Willems, Menno D de Jong, Dasja Pajkrt, Katja C Wolthers
Background.: Inappropriately high levels of antibiotics are still prescribed in primary health care for respiratory tract infections (RTIs). Access to diagnostic point-of-care tests (POCTs) for RTIs might reduce this over-prescription. Objective.: The purpose of our study was to determine the diagnostic performance and clinical feasibility of a recently developed diagnostic POCT for respiratory viruses, the mariPOC®, in a Dutch primary healthcare setting. Methods...
March 24, 2017: Family Practice
https://www.readbyqxmd.com/read/28359132/point-of-care-testing-in-liver-disease-and-liver-surgery
#19
Lasitha Abeysundara, Susan V Mallett, Ben Clevenger
The alterations in coagulation and hemostasis that accompany liver disease are complex, and while patients with this disease have traditionally been perceived as having a bleeding diathesis, it is now understood that in stable patients hemostasis is "re-balanced." Hepatic surgery, and particularly liver transplantation, can be associated with large fluid shifts, massive bleeding, and coagulopathy, as well as postoperative thrombosis. Point-of-care tests (POCTs) of coagulation facilitate goal-directed treatments and hemostatic monitoring in dynamic environments where the coagulation status can alter rapidly and often unpredictably...
March 30, 2017: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/28351016/nano-enabled-paper-humidity-sensor-for-mobile-based-point-of-care-lung-function-monitoring
#20
Mitradip Bhattacharjee, Harshal B Nemade, Dipankar Bandyopadhyay
The frequency of breathing and peak flow rate of exhaled air are necessary parameters to detect chronic obstructive pulmonary diseases (COPDs) such as asthma, bronchitis, or pneumonia. We developed a lung function monitoring point-of-care-testing device (LFM-POCT) consisting of mouthpiece, paper-based humidity sensor, micro-heater, and real-time monitoring unit. Fabrication of a mouthpiece of optimal length ensured that the exhaled air was focused on the humidity-sensor. The resistive relative humidity sensor was developed using a filter paper coated with nanoparticles, which could easily follow the frequency and peak flow rate of the human breathing...
March 22, 2017: Biosensors & Bioelectronics
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