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https://www.readbyqxmd.com/read/29162771/in-vivo-evidence-for-possible-up-regulating-roles-of-lysophosphatidic-acid-around-fertilization-in-rats
#1
Tae Takeda, Miki Shirasaka, Makoto Sugiyama, Ryota Terashihma, Mitsumori Kawaminami, Shiro Kurusu
Lysophosphatidic acid (LPA) produced by autotaxin (ATX) is recognized as a multi-functional mediator in mammalian reproduction. This study focused on possible effect(s) of LPA on ovulated cumulus-oocyte complexes (COCs) around fertilization in rats in vivo. Immunohistochemistry revealed the cell-type-dependent localization of candidates of synthetic enzymes, ATX and two phospholipases A2 isofroms, and LPA receptors LPA1~4 in ovulated COCs and in oviductal epithelium. The eggs ovulated with a form of COCs became denuded of cumulus cells and underwent fragmentation in the absence of fertilization...
November 21, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29146469/percutaneous-transcystic-balloon-dilation-for-common-bile-duct-stone-removal-in-high-surgical-risk-patients-with-acute-cholecystitis-and-co-existing-choledocholithiasis
#2
Wujie Wang, Changjun Wang, Hongjun Qi, Yongzheng Wang, Yuliang Li
BACKGROUND: Percutaneous procedures to treat common bile duct (CBD) stones typically require access via intrahepatic bile ducts. This study aimed to describe the outcomes of a percutaneous transcystic approach that expelled the CBD stones into the duodenum after percutaneous transcystic balloon dilation of the ampulla (PTCBDA) for high-risk patients who present with acute cholecystitis and CBD stones. METHODS: Patients diagnosed with acute cholecystitis and CBD stones who were deemed too high-risk for surgery or general anesthesia and were treated with PTCBDA and CBD stone removal between March 2010 and November 2015 were included for further analysis...
November 13, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29137005/bare-metal-stents-across-the-vater-s-ampulla-is-a-safe-method-for-patients-with-lower-bile-duct-obstruction
#3
Xiao-Nan Mao, Zai-Ming Lu, Feng Wen, Hong-Yuan Liang, Qi-Yong Guo
This study explored the effect of the implant position of stents across the Vater's ampulla on treatment outcomes in patients with lower bile duct obstruction.In the retrospective study, 41 patients with malignant obstruction of the lower bile duct and obstructive jaundice received percutaneous transhepatic biliary placement of bare-metal stents. Basic demographic data on patients, such as sex, age, and primary diseases, and follow-up data, including postoperative complications and jaundice-free survival, were recorded...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29134695/acute-stimulation-of-a-smooth-muscle-constrictor-by-oestradiol-17%C3%AE-via-gper1-in-bovine-oviducts
#4
T Nishie, Y Kobayashi, K Kimura, K Okuda
Oviducts play roles in reproductive processes, including gametes transport, fertilization and early embryo development. Oviductal transport is controlled by various factors such as endothelins (EDNs) and nitric oxide (NO), smooth muscle contracting and relaxing factor, respectively. EDNs and NO production depend on an ovarian steroid hormone, oestradiol-17β (E2) and E2 quickly exerts their biological functions through G protein-coupled oestrogen receptor 1 (GPER1), which mediates rapid intracellular signalling...
November 14, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29134136/creating-a-full-thickness-choroidal-incision-an-ex-vivo-analysis-of-human-and-porcine-tissue-contraction-dynamics
#5
Stephen A LoBue, Norihiro Yamada, Moon Jeong Choi, Timothy W Olsen
Purpose: We hypothesized that the elastic nature of the choroid leads to tissue contraction following a full-thickness, sharp incision. Furthermore, we sought to quantify, measure, and compare tissue contraction in ex vivo porcine globes and human globes of various ages using predetermined variables. Method: A full-thickness, ex vivo choroidal incision was performed in either pig (n = 97) or human (n = 30) specimens. Variables included trephine diameter (1.5, 2...
November 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29131967/prognostic-role-of-the-neutrophil-to-lymphocyte-ratio-nlr-in-patients-with-operable-ampullary-carcinoma
#6
Nebi Serkan Demirci, Gokmen Umut Erdem
Ampullary carcinoma or cancer of the ampulla of Vater is a rare malignancy with a high recurrence rate. Although cost-effective biomarkers, such as neutrophil-to-lymphocyte ratio (NLR), have been investigated in other cancers for predicting postoperative prognosis in patients, studies on the role of NLR in ampullary cancer are scarce. Here we aimed to evaluate the prognostic significance of the preoperative neutrophil-to-lymphocyte ratio (NLR) in patients with operable ampullary carcinoma. We retrospectively reviewed 87 patients who underwent pancreaticoduodenectomy for the treatment of ampullary carcinoma between December 1999 and April 2014...
November 13, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29122597/upper-gi-involvement-in-children-with-familial-adenomatous-polyposis-syndrome-single-center-experience-and-meta-analysis-of-the-literature
#7
Luz H Gutierrez Sanchez, Mouaz Alsawas, Michael Stephens, Mohammad Hassan Murad, Imad Absah
BACKGROUND AND AIMS: Familial adenomatous polyposis (FAP) is a hereditary syndrome that can affect the entire GI tract. Current screening recommendations include esophagogastroduodenoscopy (EGD) starting at age 25 to 30 years or earlier in symptomatic patients. However, there are few reports describing upper GI tract involvement in children with FAP which support the notion of early screening. The aim of our study is to understand the prevalence and severity of upper GI involvement in children with FAP...
November 6, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29121415/efficacy-and-safety-of-trametinib-in-japanese-patients-with-advanced-biliary-tract-cancers-refractory-to-gemcitabine
#8
Masafumi Ikeda, Tatsuya Ioka, Akira Fukutomi, Chigusa Morizane, Akiyoshi Kasuga, Hideaki Takahashi, Akiko Todaka, Takuji Okusaka, Caretha L Creasy, Shelby Gorman, Daniel J Felitsky, Mikiro Kobayashi, Fanghong Zhang, Junji Furuse
Gemcitabine-based therapy remains the mainstay of treatment for patients with biliary tract cancers (BTCs) with no second-line treatment(s) established yet. Aberrant activation of MAPK pathway in patients with BTC indicates its importance in BTC. Trametinib is a potent, highly selective, allosteric non-competitive inhibitor of MEK1/MEK2. In this Phase IIa open-label, single-arm study, we investigated efficacy and safety of trametinib in Japanese patients with advanced BTC refractory to gemcitabine-based therapy...
November 9, 2017: Cancer Science
https://www.readbyqxmd.com/read/29097063/expression-and-localization-of-polypeptide-n-acetylgalactosaminyltransferase-like-protein-5-in-the-reproductive-organs-and-sperm-of-hu-sheep
#9
Xiaolei Yao, M A Ei-Samahy, Xu Feng, Tinging Zhang, Fengzhe Li, Guomin Zhang, Jing Pang, Haitao Nie, Feng Wang
The polypeptide N-acetylgalactosaminyltransferase-like protein 5 (GALNTL5) is involved in male fertility; however, its involvement in the reproduction and fertility of females remains unclear. Therefore, the present study aimed to examine the presence of GALNTL5 in the reproductive organs of ewes during the estrus period and to investigate its expression in cauda epididymal and ejaculated sperm. Results showed that GALNTL5 mRNA and protein were present in some reproductive organs of ewes during the estrus period...
October 27, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/29060967/-significance-and-expression-of-pax8-pax2-p53-and-ras-in-ovary-and-fallopian-tubes-to-origin-of-ovarian-high-grade-serous-carcinoma
#10
Y N Mao, L X Zeng, Y H Li, Y Z Liu, J Y Wu, L Li, Q Wang
Objective: To explore the origin of ovarian high grade serous carcinoma (HGSC) through analysing the expression and significance of PAX8, PAX2, p53 and RAS in the ovary and fallopian tube of different types and grades of serous carcinoma. Methods: A total of 44 cases tissue samples of ovarian tumor including 34 malignant ovarian tumor and 10 normal normal tissue (as control group) were collected from the admitted patients in Affiliated Tumor Hospital of Guangxi Medical University from January 2015 to January 2016...
October 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/29037958/expression-of-pd-1-and-pd-l1-in-poorly-differentiated-neuroendocrine-carcinomas-of-the-digestive-system-a-potential-target-for-anti-pd-1-pd-l1-therapy
#11
Jordan A Roberts, Raul S Gonzalez, Satya Das, Jordan Berlin, Chanjuan Shi
Poorly-differentiated neuroendocrine carcinoma of the digestive system has a dismal prognosis with limited treatment options. This study aimed to investigate expression of the PD-1/PD-L1 pathway in these tumors. Thirty-seven patients with a poorly-differentiated neuroendocrine carcinoma of the digestive system were identified. Their electronic medical records, pathology reports and pathology slides were reviewed for demographics, clinical history and pathologic features. Tumor sections were immunohistochemically labeled for PD-1 and PD-L1 and expression of PD-1 and PD-L1 on tumor and tumor-associated immune cells was analyzed and compared between small cell and large cell neuroendocrine carcinomas...
October 13, 2017: Human Pathology
https://www.readbyqxmd.com/read/28990001/safety-of-duodenal-ampullectomy-for-benign-periampullary-tumors
#12
Alvin Lyle Kim, Young Il Choi
BACKGROUNDS/AIMS: Surgical resection, such as pancreaticoduodenectomy (PD), is used for treatment of benign periampullary tumors, but high morbidity and mortality resulting from PD can be a huddle. The aim of this study is to suggest a safe and less invasive procedure for treatment of benign periampullary tumors. METHODS: From January 2001 to September 2016, 31 patients with ampulla of Vater (AOV) tumors were reviewed retrospectively. Patients who were confirmed with malignancy through biopsy were excluded, except for one patient with malignancy and multiple underlying diseases...
August 2017: Annals of Hepato-Biliary-Pancreatic Surgery
https://www.readbyqxmd.com/read/28989008/metastatic-melanoma-in-the-ampulla-of-vater
#13
Kohei Yamakawa, Akira Kurita, Shunjiro Azuma, Yasushi Kudo, Shujiro Yazumi
No abstract text is available yet for this article.
October 5, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28982258/international-study-of-endoscopic-management-of-distal-malignant-biliary-obstruction-combined-with-duodenal-obstruction
#14
Tsuyoshi Hamada, Yousuke Nakai, James Y Lau, Jong Ho Moon, Tsuyoshi Hayashi, Ichiro Yasuda, Bing Hu, Dong-Wan Seo, Hiroshi Kawakami, Masaki Kuwatani, Akio Katanuma, Masayuki Kitano, Shomei Ryozawa, Keiji Hanada, Takuji Iwashita, Yukiko Ito, Hiroshi Yagioka, Osamu Togawa, Iruru Maetani, Hiroyuki Isayama
OBJECTIVE: Endoscopic transpapillary or endoscopic ultrasound (EUS)-guided stent placement is used for nonresectable distal malignant biliary obstruction. We conducted a retrospective study to evaluate endoscopic biliary drainage in patients with duodenal obstruction. METHODS: We included consecutive patients who underwent endoscopic biliary drainage combined with a duodenal stent at 16 referral centers in four Asian countries. The primary outcome was time to recurrent biliary obstruction (TRBO)...
October 6, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28959430/operable-synchronous-ampullary-carcinoma-and-hepatocellular-carcinoma-a-case-report-and-review-of-the-literature
#15
Marson Davidson, Miriam Aioub, Martin Gutierrez, Kunchang Song, Ellen Hagopian, Martin Karpeh
We report a rare case of synchronous double primary malignancies of the liver and ampulla. A 70-year-old white female was diagnosed with ampullary and hepatocellular carcinoma. The management and outcome of this rare case of synchronous double primary hepatic and periampullary malignancies, amenable to surgical resection is discussed.
September 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28940594/characteristics-of-bioelectrical-activity-of-oviducts-and-uterus-during-early-pregnancy-in-sows-recorded-by-telemetry-method
#16
Bartosz Pawlinski, Malgorzata Domino, Romuald Zabielski, Katarzyna Siewruk, Malgorzata Polanska-Plachta, Zdzislaw Gajewski
The aim of the present study was to record the myoelectric activity of the reproduction tract in sows during the estrous phase and the early pregnancy period via telemetry recording system. In a total of eight non-pregnant pigs, the bioelectrical activity was recorded through three silicone electrodes sutured on the oviduct (isthmus and ampulla) and the uterine horn. Blood samples were collected to monitor the levels of progesterone (P4) and luteinizing hormone (LH). The estrous cycle was synchronized with eCG and hCG and the animals were subjected to artificial insemination (AI)...
September 21, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28925490/multi-detector-spiral-ct-diagnosis-of-common-bile-duct-ampullary-carcinoma
#17
D-Z Zhao, Y Guo, Y-P Sun, H-M Liu, Z Zhang, Q-L Ma, Y-S Wang, C-L Chen
OBJECTIVE: The aim of this project was to study the imaging characteristics of multi-detector CT (MDCT) in different types of malignant tumor in the common bile duct ampulla. PATIENTS AND METHODS: We examined 30 cases of pancreatic head cancer, 35 of terminal cholangiocarcinoma, 26 of ampullary carcinoma, and 40 of benign lesions, all confirmed by pathology. We used 64-slice spiral CT plain scan and multi-phase enhanced scan with multi-planar reconstruction (MPR) and curved planar reconstruction (CPR) post-processing to obtain three-dimensional images...
August 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28918475/octopaminergic-innervation-and-a-neurohaemal-release-site-in-the-antennal-heart-of-the-locust-schistocerca-gregaria
#18
Victoria Antemann, Günther Pass, Hans-Joachim Pflüger
A detailed account is given by the octopaminergic innervation of the antennal heart in Schistocerca gregaria using various immunohistochemical methods. Anterograde axonal filling illustrates the unilateral innervation on the medial ventral surface of the pumping muscle of the antennal heart via the paired corpora cardiaca nerve III. In addition, antibody staining revealed that ascending axons of this nerve terminate at the ampullae of the antennal heart forming synaptoid structures and extensive neurohaemal release sites...
September 16, 2017: Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology
https://www.readbyqxmd.com/read/28915245/effects-of-gnrh-vaccination-in-wild-and-captive-african-elephant-bulls-loxodonta-africana-on-reproductive-organs-and-semen-quality
#19
Imke Lueders, Debbie Young, Liana Maree, Gerhard van der Horst, Ilse Luther, Stephan Botha, Brendan Tindall, Geoffrey Fosgate, André Ganswindt, Henk J Bertschinger
OBJECTIVES: Although the African elephant (Loxodonta africana) is classified as endangered by the International Union for Conservation of Nature (IUCN), in some isolated habitats in southern Africa, contraception is of major interest due to local overpopulation. GnRH vaccination has been promoted as a non-invasive contraceptive measure for population management of overabundant wildlife. We tested the efficacy of this treatment for fertility control in elephant bulls. METHODS: In total, 17 male African elephants that were treated with a GnRH vaccine were examined in two groups...
2017: PloS One
https://www.readbyqxmd.com/read/28900465/cytologic-features-of-tubular-adenoma-of-ampulla-causing-distal-common-bile-duct-stricture-a-case-report-and-review-of-the-literature
#20
Sangeeta Mantoo, Madhusudhan R Sanaka, Deborah J Chute
Adenomas of the ampulla of Vater are distinctly rare, representing <10% of periampullary neoplasms. Very few reports of the cytologic features of ampullary adenomas are present in literature, particularly in bile duct brushing samples. A case report and review of the literature is presented. The typical cytologic features of ampullary adenomas on cytologic preparations include tall, thin columnar cells with mildly hyperchromatic elongated nuclei and nuclear pseudostratification, in a relatively clean background...
2017: CytoJournal
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