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https://www.readbyqxmd.com/read/29232697/self-management-of-type-2-diabetes-in-gulf-cooperation-council-countries-a-systematic-review
#1
Thamer Al Slamah, Barbara I Nicholl, Fatima Y Alslail, Craig A Melville
AIMS: This study aimed to systematically review intervention studies on self-management of type 2 diabetes in Gulf Cooperation Council (GCC) countries to determine the most effective self-management strategies for individuals with type 2 diabetes in this region. METHODS: A search strategy was developed using multiple databases: Medline and Embase (via Ovid), CINAHL (via EBSCO), and PubMed. Study and intervention characteristics, intervention structure, content, cultural adaptation, and outcomes were extracted from the included studies...
2017: PloS One
https://www.readbyqxmd.com/read/29228317/leukocyte-telomere-length-at-birth-and-during-the-early-life-of-hiv-exposed-uninfected-children-following-in-utero-exposure-to-antiretrovirals
#2
Abhinav Ajaykumar, Hugo Soudeyns, Fatima Kakkar, Jason Brophy, Ari Bitnun, Ariane Alimenti, Arianne Y K Albert, Deborah M Money, Hélène C F Côté
Background: Maternal combination antiretroviral therapy (cART) during pregnancy could impact the health of HIV-exposed uninfected (HEU) children, as some antiretrovirals cross the placenta and can inhibit telomerase. Our objective was to compare HEU and HIV-unexposed uninfected (HUU) leukocyte telomere length (LTL) at birth and in early life, and investigate any relationship with cART exposure. Methods: HEU and HUU children's blood LTL was compared cross-sectionally at birth, and during the first three years of life...
December 8, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29226301/the-2017-iuis-phenotypic-classification-for-primary-immunodeficiencies
#3
Aziz Bousfiha, Leïla Jeddane, Capucine Picard, Fatima Ailal, H Bobby Gaspar, Waleed Al-Herz, Talal Chatila, Yanick J Crow, Charlotte Cunningham-Rundles, Amos Etzioni, Jose Luis Franco, Steven M Holland, Christoph Klein, Tomohiro Morio, Hans D Ochs, Eric Oksenhendler, Jennifer Puck, Mimi L K Tang, Stuart G Tangye, Troy R Torgerson, Jean-Laurent Casanova, Kathleen E Sullivan
Since the 1990s, the International Union of Immunological Societies (IUIS) PID expert committee (EC), now called Inborn Errors of Immunity Committee, has published every other year a classification of the inborn errors of immunity. This complete catalog serves as a reference for immunologists and researchers worldwide. However, it was unadapted for clinicians at the bedside. For those, the IUIS PID EC is now publishing a phenotypical classification since 2013, which proved to be more user-friendly. There are now 320 single-gene inborn errors of immunity underlying phenotypes as diverse as infection, malignancy, allergy, auto-immunity, and auto-inflammation...
December 11, 2017: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/29226186/prevalence-of-pelvic-incontinence-in-patients-with-cystic-fibrosis
#4
Fatima Neemuchwala, Fahmida Ahmed, Samya Z Nasr
Cystic fibrosis (CF) patients are at risk for developing pelvic (urinary and/or fecal) incontinence due to progressive weakness of pelvic floor muscles secondary to recurrent episodes of coughing and respiratory infections. Many patients do not bring these symptoms to the attention of their health care providers because of social embarrassment and lack of knowledge of available effective treatment. Several studies have identified the prevalence of incontinence in CF adults and adolescents. However, few studies identified the problem in children with CF...
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/29226045/neuroendocrine-tumor-of-the-cystic-duct-a-rare-and-incidental-diagnosis
#5
Fatima Ayub, Muhammad W Saif
Neuroendocrine tumors (NETs), also known as carcinoid tumors of the extrahepatic biliary tree, are extremely rare malignancies and account for 0.2% to 2% of all carcinoids of the gastrointestinal tract. The most common sites include NET in the common bile duct (CBD), followed by the perihilar region, cystic duct, and common hepatic duct (CHD). A review of the literature showed only eight cases of NETs of the cystic duct and we, hereby, present the ninth case of NET of the cystic duct in a 50-year-old woman...
October 6, 2017: Curēus
https://www.readbyqxmd.com/read/29226041/dapagliflozin-cardiovascular-safety-and-benefits-in-type-2-diabetes-mellitus
#6
REVIEW
Fatima Saleem
Sodium-glucose co-transporter 2 inhibitors (SGLT2is) such as dapagliflozin, canagliflozin, and empagliflozin, are a promising new therapy in the treatment of type 2 diabetes mellitus (T2DM). SGLT2is can effectively reduce hyperglycemia thus improving glycemic control and they offer some beneficial effects on the cardiovascular (CV) system which can benefit patients with heart failure in addition toT2DM. The United States Food and Drug Administration requires new diabetes mellitus therapies to show a CV safety profile...
October 5, 2017: Curēus
https://www.readbyqxmd.com/read/29225987/daptomycin-induced-acute-eosinophilic-pneumonia-late-onset-and-quick-recovery
#7
Mohamad Rachid, Khansa Ahmad, Meghan Saunders-Kurban, Aelia Fatima, Aditya Shah, Anas Nahhas
Background: Daptomycin is a cyclic lipopeptide antibiotic that provides great coverage for gram positive cocci. From the early years of daptomycin use, concerns were raised regarding the pulmonary side effects of daptomycin and potential development of acute eosinophilic pneumonia (AEP) secondary to daptomycin therapy. Discussion: AEP could be idiopathic or induced by drugs or toxins. It is a distinct entity from atopic diseases and autoimmune, parasitic, or fungal infections that can also cause pulmonary eosinophilia...
2017: Case Reports in Pulmonology
https://www.readbyqxmd.com/read/29225831/delayed-right-ventricular-lead-perforation-complicated-by-tamponade-in-biventricular-hypertrophic-cardiomyopathy
#8
Najla Kourireche, Amal Boutakhrit, Fatima Chikhi, Ibtissam Fellat, Mohammed Cherti
This report highlights the importance of a more cautious approach in a patient with a history of implanted cardiac leads presenting with chest pain or dyspnea, to prevent overlooking cardiac lead perforations especially in hypertrophic cardiomyopathy which seems to be not absolutely protective.
December 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29225105/interpretation-of-b-type-natriuretic-peptides-in-the-era-of-angiotensin-receptor-neprilysin-inhibitors
#9
Paulo Bettencourt, Cândida Fonseca, Fátima Franco, Aurora Andrade, Dulce Brito
Assessment of serum levels of natriuretic peptides, especially the amino-terminal portion (NT-proBNP) and the carboxy-terminal portion (BNP) of pro-B-type natriuretic peptide, has had a highly significant clinical impact on the diagnosis and prognostic stratification of patients with heart failure (HF). They are now an instrument with recognized value in this context and several studies have demonstrated their value in tailoring therapy for these patients. Following the recent advent of angiotensin receptor-neprilysin inhibitors (ARNIs), there is a need to review how these two biomarkers are interpreted in HF...
December 7, 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29224811/cancer-stem-cell-and-its-niche-in-malignant-progression-of-oral-potentially-malignant-disorders
#10
Subin Surendran, Gangotri Siddappa, Amrutha Mohan, Wesley Hicks, Vijayvel Jayaprakash, Christina Mimikos, Mohammed Mahri, Fatima Almarzouki, Kayla Morrell, Ravindra Ravi, Sindhu Govindan, C N Sushma, Nisheena Raghavan, Praveen Birur, Jeyaram Ilayaraja, Mihai Merzianu, Mary Reid, Amritha Suresh, Moni Abraham Kuriakose
OBJECTIVE: The purpose of this study was to determine association between cancer stem cells (CSCs) and their niche with progression of oral potentially malignant disorders. MATERIALS AND METHODS: Patients with histologically confirmed oral potentially malignant disorders, stratified into high/low risk lesions based on the degree of dysplasia and oral cancer were included in this study. Immunohistochemical profiling of markers of CSCs (CD44), endothelial cells (CD31) and CSC-vascular niche cross-talk (CXCR4 and SDF1) were carried out...
December 2017: Oral Oncology
https://www.readbyqxmd.com/read/29223806/preventing-the-n-terminal-processing-of-human-interferon-%C3%AE-2b-and-its-chimeric-derivatives-expressed-in-escherichia-coli
#11
Fatima Ahsan, Qurratulann Afza Gardner, Naeem Rashid, Greg J Towers, Muhammad Akhtar
We have previously shown that human interferon α-2b (IFN) produced in Escherichia coli (E. coli) is heterogeneous at the N-terminal, with three major species (Ahsan et al., 2014). These are: (a) the direct translation product of the gene retaining the N-terminal methionine, (b) a species from which the methionyl residue has been removed by E. coli methionyl aminopeptidase to give the native interferon α-2b and (c) in which the N-terminal Cys residue of the latter contains an acetyl group. In this paper we overcome this heterogeneity, using engineered interferon derivatives with phenylalanine residue directly downstream of the N-terminal methionine (Met-Phe-IFN)...
November 23, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29222431/utilization-of-blood-by-products-an-in-silico-and-experimental-combined-study-for-bsa-usage
#12
Fátima Arrutia, Rebeca Fernández, Carlos Menéndez, Ulises A González, Francisco A Riera
In order to exploit industrial discards, protein enzymatic hydrolysis is a currently popular methodology for obtaining bioactive peptides. However, once released, most promising peptides have to be selected from the mixture. In this work, the suitability of pepsin (EC 3.4.23.1) to hydrolyse serum albumin in order to obtain bioactive peptides was assessed. Then, a suitable process to obtain best separation of bioactive peptides was evaluated, using polyethersulfone membranes at different pH values. Serum albumin was easily hydrolysed by pepsin, reaching a DH value of the 65...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29221850/isolation-and-molecular-characterization-of-leishmania-infantum-in-urine-from-patients-with-visceral-leishmaniasis-in-brazil
#13
Manoel Sebastião da Costa Lima, Andressa Cristina Lopes Hartkopf, Rosianne A de Souza Tsujisaki, Elisa Teruya Oshiro, Julie Teresa Shapiro, Maria de Fatima Cepa Matos, Maria Elizabeth Cavalheiros Dorval
Leishmania infantum is a protozoan that causes visceral leishmaniasis, a potentially deadly neglected tropical disease. The gold standard for diagnosis has traditionally been detection of amastigotes in bone marrow or spleen aspirates, but this is an invasive procedure that carries the risk of serious complications. Newer PCR techniques are opening new avenues and tissues for testing. Therefore, we tested if amastigotes and DNA from L. infantum could be detected in patient urine. We detected L. infantum DNA in six out of 30 urine samples from patients with visceral leishmaniasis and the promastigotes were isolated in culture from the urine of one patient...
December 6, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29220543/skin-cancer-prevention-campaign-in-childhood-survey-based-on-3-676-children-in-brazil
#14
Paulo Ricardo Criado, Jorge Ocampo-Garza, Anne Lise Dias, Walter Belda Junior, Nilton Di Chiachio, Aparecida Machado de Moraes, Meire Brasil Parada, Fátima de Oliveira Rabay, Octavio Moraes Junior, Renato Sau Rios, Cristiana Silveira da Silva, Francisco C S Ferreira, Samuel Henrique Mandeulbaum, Cidia Vasconcellos
BACKGROUND AND OBJECTIVES: Primary skin cancer prevention campaigns are essential and more effective among children, not only because of the importance of sun exposure effects during this period, but also because at this age is when individuals are developing behaviors. The Brazilian Society of Dermatology - Regional State of Sao Paulo developed and conducted, the program named "The Sun, Friend of Childhood", a school health education and disease prevention project for children and parents...
December 8, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29219226/getting-there-and-around-host-range-oscillations-during-colonisation-of-the-canary-islands-by-the-parasitic-nematode-spauligodon
#15
Fátima Jorge, Ana Perera, Robert Poulin, Vicente Roca, Miguel A Carretero
Episodes of expansion and isolation in geographic range over space and time, during which parasites have the opportunity to expand their host range, are linked to the development of host-parasite mosaic assemblages and parasite diversification. In this study we investigated whether island colonisation events lead to host range oscillations in a taxon of host-specific parasitic nematodes of the genus Spauligodon in the Canary Islands. We further investigated if range oscillations also resulted in shifts in host breadth (i...
December 8, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/29218998/vkorc1-1639a-allele-influences-warfarin-maintenance-dosage-among-blacks-receiving-warfarin-anticoagulation-a-retrospective-cohort-study
#16
Fatima Donia Mili, Tenecia Allen, Paula Weinstein Wadell, W Craig Hooper, Christine De Staercke, Christopher J Bean, Cathy Lally, Harland Austin, Nanette K Wenger
AIM: The study objectives were to investigate the association between selected CYP2C9 and VKORC1 single nucleotide polymorphisms with serious bleeding or thrombotic risk, and to estimate mean daily maintenance dose of warfarin and international normalized ratio measurements among Blacks receiving warfarin anticoagulation. METHODS: We conducted a retrospective cohort study among 230 Black adults receiving warfarin for a minimum of three consecutive months with a confirmed date of first dosage...
December 8, 2017: Future Cardiology
https://www.readbyqxmd.com/read/29218861/comparative-expression-patterns-of-sox2-and-sox19-genes-in-the-forebrain-of-developing-and-adult-turbot-scophthalmus-maximus
#17
Xoana Taboada, Ana Viñas, Fátima Adrio
The turbot, Scophthalmus maximus, belongs to the flatfishes (order Pleuronectiformes), which display substantial asymmetry of the olfactory organs and forebrain. Sox genes code for SRY-related HMG domain-bearing transcription factors involved in various developmental processes. Group B1 Sox genes as Sox2 and Sox19 appear to play major roles in neural development. Here, we characterized by in situ hybridization the developmental expression of Sox2 and Sox19 genes in metamorphic and postmetamorphic specimens and young adults of both sexes...
December 8, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29218556/structural-characterization-of-highly-flexible-proteins-by-small-angle-scattering
#18
Tiago N Cordeiro, Fátima Herranz-Trillo, Annika Urbanek, Alejandro Estaña, Juan Cortés, Nathalie Sibille, Pau Bernadó
Intrinsically Disordered Proteins (IDPs) are fundamental actors of biological processes. Their inherent plasticity facilitates very specialized tasks in cell regulation and signalling, and their malfunction is linked to severe pathologies. Understanding the functional role of disorder requires the structural characterization of IDPs and the complexes they form. Small-angle Scattering of X-rays (SAXS) and Neutrons (SANS) have notably contributed to this structural understanding. In this review we summarize the most relevant developments in the field of SAS studies of disordered proteins...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29215003/rhythmic-potassium-transport-regulates-the-circadian-clock-in-human-red-blood-cells
#19
Erin A Henslee, Priya Crosby, Stephen J Kitcatt, Jack S W Parry, Andrea Bernardini, Rula G Abdallat, Gabriella Braun, Henry O Fatoyinbo, Esther J Harrison, Rachel S Edgar, Kai F Hoettges, Akhilesh B Reddy, Rita I Jabr, Malcolm von Schantz, John S O'Neill, Fatima H Labeed
Circadian rhythms organize many aspects of cell biology and physiology to a daily temporal program that depends on clock gene expression cycles in most mammalian cell types. However, circadian rhythms are also observed in isolated mammalian red blood cells (RBCs), which lack nuclei, suggesting the existence of post-translational cellular clock mechanisms in these cells. Here we show using electrophysiological and pharmacological approaches that human RBCs display circadian regulation of membrane conductance and cytoplasmic conductivity that depends on the cycling of cytoplasmic K+ levels...
December 7, 2017: Nature Communications
https://www.readbyqxmd.com/read/29211245/low-dose-systemic-or-intralesional-meglumine-antimoniate-treatment-for-american-tegumentary-leishmaniasis-results-in-low-lethality-low-incidence-of-relapse-and-low-late-mucosal-involvement-in-a-referral-centre-in-rio-de-janeiro-brazil-2001-2013
#20
Lucia Regina Brahim, Cláudia Maria Valete-Rosalino, Liliane de Fátima Antônio, Maria Inês Fernandes Pimentel, Marcelo Rosandiski Lyra, Luiz Eduardo de Carvalho Paes, Ananda Dutra da Costa, Iracema Forni Vieira, Cristina Maria Giordano Dias, Maria Cristina de Oliveira Duque, Mauro Celio de Almeida Marzochi, Armando de Oliveira Schubach
BACKGROUND: American tegumentary leishmaniasis (ATL) is a non-lethal parasitic disease that presents with cutaneous (CL) and mucosal (ML) clinical forms. ATL treatment aims at healing the lesions and preventing the development of the late mucosal form. Systemic meglumine antimoniate (MA) therapy with 10-20 mg Sb5+/kg/day is the first choice of treatment. However, alternative therapies using 5 mg Sb5+/kg/day or intralesional (IL) MA are the usual regimens at the National Institute of Infectious Diseases (NIID), Rio de Janeiro, Brazil...
December 2017: Memórias do Instituto Oswaldo Cruz
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