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https://www.readbyqxmd.com/read/29653427/potential-of-portuguese-vine-shoot-wastes-as-natural-resources-of-bioactive-compounds
#1
Manuela M Moreira, M Fátima Barroso, João Vasconcellos Porto, M J Ramalhosa, Jaroslava Švarc-Gajić, Letícia Estevinho, Simone Morais, Cristina Delerue-Matos
Since annually a high amount of wastes is produced in vine pruning, the aim of this study was to evaluate the potential of vine shoots from two Portuguese grape varieties (Touriga Nacional - TN and Tinta Roriz - TR) to be used as a natural source of phenolic compounds. To reach this goal, three techniques were explored, namely microwave-assisted extraction (MAE), subcritical water extraction (SWE) and conventional extraction (CE). The phenolic composition of the extracts, antioxidant and biological activities were evaluated by spectrophotometry and chromatography...
April 10, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29653140/in-vitro-mechanical-stimulation-facilitates-stress-dissipation-and-sealing-ability-at-the-conventional-glass-ionomer-cement-dentin-interface
#2
Manuel Toledano, Raquel Osorio, Estrella Osorio, Inmaculada Cabello, Manuel Toledano-Osorio, Fátima S Aguilera
OBJECTIVE: The aim of this study was to evaluate the induced changes in the chemical and mechanical performance at the glass-ionomer cement-dentin interface after mechanical load application. METHODS: A conventional glass-ionomer cement (GIC) (Ketac Bond), and a resin-modified glass-ionomer cement (RMGIC) (Vitrebond Plus) were used. Bonded interfaces were stored in simulated body fluid, and then tested or submitted to the mechanical loading challenge. Different loading waveforms were applied: No cycling, 24 h cycled in sine or loaded in sustained hold waveforms...
April 10, 2018: Journal of Dentistry
https://www.readbyqxmd.com/read/29652644/alphaviruses-serological-evidence-of-human-infection-in-paraguay-2012-2013
#3
Fátima Cardozo, Brenda Konigheim, Guillermo Albrieu-Llinás, María Elisa Rivarola, Javier Aguilar, Alejandra Rojas, Agustín Ignacio Quaglia, Malvina Paez, Yvalena Guillén, Adrian Diaz, María Asunción Vallejos, Lilian Herebia, María Lidia Recalde, Marta Silvia Contigiani, Laura Mendoza
INTRODUCTION: Alphaviruses can produce febrile illness and encephalitis in dead-end hosts such as horses and humans. Within this genus, the Venezuelan Equine Encephalitis virus (VEEV) complex includes pathogenic epizootic subtypes and enzootic subtypes that are not pathogenic in horses (except subtype IE, Mexican strains), although they can cause febrile symptoms in humans. The Rio Negro virus (RNV-VEEV subtype VI) circulates in Argentina, where it was associated with undifferentiated febrile illness...
March 13, 2018: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29652571/hemolasertherapy-a-novel-procedure-for-gingival-papilla-regeneration-case-report
#4
Fatima Zanin, Maria Stella Moreira, Ana Clara Fagundes Pedroni, Mateus Windlin, Ana Paula Brugnera, Aldo Brugnera Júnior, Marcia Martins Marques
BACKGROUND: Interdental papilla is of major importance to patients' orofacial aesthetics, especially regarding anterior teeth as part of the smile's harmony. Loss of gingival tissue, which constitutes interdental papilla, forms what in odontology is called black spaces. This loss, besides affecting the smile's aesthetics, also provokes phonetic and functional damage. OBJECTIVE: The objective of the authors is to present the result of three clinical cases treated with an innovative technique called hemolasertherapy, which stimulates growth of gingival papilla and thus permanently fills in the black spaces...
April 2018: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/29652357/dynamic-mechanical-analysis-on-fused-polymer-optical-fibers-towards-sensor-applications
#5
Arnaldo Leal-Junior, Anselmo Frizera, Maria José Pontes, Paulo Antunes, Nélia Alberto, Maria Fátima Domingues, Heeyoung Lee, Ryo Ishikawa, Yosuke Mizuno, Kentaro Nakamura, Paulo André, Carlos Marques
This Letter presents, for the first time, to the best of our knowledge, the dynamic mechanical analysis of a polymer optical fiber (POF) that was previously damaged by the catastrophic fuse effect. The variation of the fiber Young's modulus was evaluated with respect to the increase of temperature, humidity, and frequency of strain cycles. The obtained data for the fused POF are compared with the ones for the same POF without the fuse effect. The results show the feasibility of the fused POF for sensor applications, such as strain and acceleration measurement, since it presents temperature sensitivity almost two times lower in temperatures between 26°C and 90°C and Young's modulus 2...
April 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29652190/anal-cytology-institutional-statistics-correlation-with-histology-and-development-of-multidisciplinary-screening-program-with-review-of-the-current-literature
#6
Elizabeth G Morency, Tracey Harbert, Nazneen Fatima, Julia Samolcyzk, Kruti P Maniar, Ritu Nayar
CONTEXT: - The incidence of anal cancer in the United States is on the rise in high-risk populations. The anal Papanicolaou test (APT) is advocated as a screening tool, in addition to digital rectal examination and high-resolution anoscopy. OBJECTIVE: - To review our experience and the current literature to create, in cooperation with clinicians, a standardized screening and treatment algorithm given our large volume of APTs. DATA SOURCES: - All APTs collected between January 2013 and June 2015 were reviewed and correlated with follow-up/concurrent biopsy diagnoses, and clinical and social history...
April 13, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29651943/benzoin-schiff-bases-design-synthesis-and-biological-evaluation-as-potential-antitumor-agents
#7
Dima A Sabbah, Fatima Al-Tarawneh, Wamidh H Talib, Kamal Sweidan, Sanaa K Bardaweel, Eveen Al-Shalabi, Haizhen A Zhong, Ghassan Abu Sheikha, Reema Abu Khalaf, Mohammad S Mubarak
BACKGROUND: Phosphoinositide 3-kinase α (PI3Kα) is an attractive target for anticancer drug design. OBJECTIVES: Target compounds were designed to probe the significance of alcohol and imine moieties tailored on a benzoin scaffold to better understand the structure activity relation (SAR) and improve their biological activity as anticancer compounds. METHODS: Chemical synthesis of the targeted compounds, biological evaluation tests against human colon adenocarcinoma (HCT-116), breast adenocarcinoma (MCF-7), and breast carcinoma (T47D) cell lines, as well as Glide docking studies were employed in this investigation...
April 12, 2018: Medicinal Chemistry
https://www.readbyqxmd.com/read/29651934/effects-of-curcumin-on-squamous-cell-carcinoma-of-tongue-an-in-vitro-study
#8
Lorenzo Lo Muzio, Fatima Ardito
BACKGROUND: The squamous cell carcinoma of the tongue (TSCC) is the most frequent cancer of oral cavity often characterized by poor prognosis. Conventional therapies are not very efficient and often may cause serious side effects. In this contest, introduction of natural substances as possible adjuvant in the treatment and prevention of cancer is becoming a relevant topic. In fact, curcumin has been used for decades in Chinese traditional medicine for its beneficial effects. Curcumin has anti-cancer properties in many tumors however, its action on the tongue carcinoma is not entirely clear and many other investigations are necessary...
April 12, 2018: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29650578/draft-genome-sequences-of-three-ochrobactrum-spp-isolated-from-different-avian-hosts-in-pakistan
#9
Poonam Sharma, Lindsay F Killmaster, Jeremy D Volkening, Stivalis Cardenas-Garcia, Abdul Wajid, Shafqat Fatima Rehmani, Asma Basharat, Patti J Miller, Claudio L Afonso
Here, we present the draft genome sequences of three Ochrobactrum sp. strains with multidrug-resistant properties, isolated in 2015 from a pigeon and two chickens in Pakistan.
April 12, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29649704/pesticide-degradation-and-export-losses-at-the-catchment-scale-insights-from-compound-specific-isotope-analysis-csia
#10
Pablo Alvarez-Zaldívar, Sylvain Payraudeau, Fatima Meite, Jeremy Masbou, Gwenaël Imfeld
Although pesticides undergo degradation tests prior to use, determining their export, degradation and persistence under field conditions remains a challenge for water resource management. Compound specific isotope analysis (CSIA) can provide evidence of contaminant degradation extent, as it is generally independent of non-destructive dissipation (e.g., dilution, sorption, volatilization) regulating environmental concentrations. While this approach has been successfully implemented in subsurface environments, its application to pesticides in near-surface hydrological contexts at catchment scale is lacking...
March 29, 2018: Water Research
https://www.readbyqxmd.com/read/29649698/enantiomer-specific-stable-carbon-isotope-analysis-esia-to-evaluate-degradation-of-the-chiral-fungicide-metalaxyl-in-soils
#11
Jérémy Masbou, Fatima Meite, Benoît Guyot, Gwenaël Imfeld
Chiral pesticides are often degraded enantioselectively in soils, leading to disparity among enantiomers that may display different toxicity levels. Monitoring pesticide degradation extents and processes remains out of reach in the field using conventional bulk and enantiomer concentration analyses. Enantioselective stable carbon isotope analysis (ESIA) combines compound specific isotope analysis (CSIA) and enantioselective analysis, and bears potential to distinguish enantiomer degradation from non-destructive dissipation...
March 29, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29649481/role-of-i%C3%AE%C2%BAb-kinase-%C3%AE-in-regulating-the-remodeling-of-the-carma1-bcl10-malt1-complex
#12
Zubair A Karim, Nicole R Hensch, Hanan Qasim, Fatima Z Alshbool, Fadi T Khasawneh
The current work investigates the notion that inducible clustering of signaling mediators of the IKK pathway is important for platelet activation. Thus, while the CARMA1, Bcl10, and MALT1 (CBM) complex is essential for triggering IKK/NF-κB activation upon platelet stimulation, the signals that elicit its formation and downstream effector activation remain elusive. We demonstrate herein that IKKβ is involved in membrane fusion, and serves as a critical protein kinase required for initial formation and the regulation of the CARMA1/MALT1/Bcl10/CBM complex in platelets...
April 9, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29643883/comparison-of-volume-and-frequency-advancement-feeding-protocols-in-very-low-birth-weight-neonates
#13
Afaq Hussain, Abdur Rehman, Nazia Fatima
Objective: To determine the outcomes in very low birth weight (VLBW) neonates receiving volume advancement versus frequency advancement feeding protocols. Methods: This controlled clinical trial was conducted in Children Hospital Multan within duration of 6 months from February 2017 to August 2017. VLBW neonates having weight < 1500 g at the time of birth were included. The protocol for frequency advancement (FA) group was to give 1 ml/kg human or pre-formula milk after every 8 hours and in volume advancement (VA) group after every 3 hours initially...
January 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29642963/nanoencapsulation-of-benznidazole-in-calcium-carbonate-increases-its-selectivity-to-trypanosoma-cruzi
#14
Louise Donadello Tessarolo, Ramon Róseo Paula Pessoa Bezerra de Menezes, Clarissa Perdigão Mello, Dânya Bandeira Lima, Emanuel Paula Magalhães, Eveline Matias Bezerra, Francisco Adilson Matos Sales, Ito Liberato Barroso Neto, Maria de Fátima Oliveira, Ricardo Pires Dos Santos, Eudenilson L Albuquerque, Valder Nogueira Freire, Alice Maria Martins
Chagas disease is a public health problem, affecting about 7 million people worldwide. Benznidazole (BZN) is the main treatment option, but it has limited effectiveness and can cause severe adverse effects. Drug delivery through nanoparticles has attracted the interest of the scientific community aiming to improve therapeutic options. The aim of this study was to evaluate the cytotoxicity of benznidazole-loaded calcium carbonate nanoparticles (BZN@CaCO3) on Trypanosoma cruzi strain Y. It was observed that BZN@CaCO3 was able to reduce the viability of epimastigote, trypomastigote and amastigote forms of T...
April 12, 2018: Parasitology
https://www.readbyqxmd.com/read/29642900/cisplatin-based-therapy-the-role-of-the-mitogen-activated-protein-kinase-signaling-pathway
#15
REVIEW
Iman W Achkar, Nabeel Abdulrahman, Hend Al-Sulaiti, Jensa Mariam Joseph, Shahab Uddin, Fatima Mraiche
Cisplatin is a widely used chemotherapeutic agent for treatment of various cancers. However, treatment with cisplatin is associated with drug resistance and several adverse side effects such as nephrotoxicity, reduced immunity towards infections and hearing loss. A Combination of cisplatin with other drugs is an approach to overcome drug resistance and reduce toxicity. The combination therapy also results in increased sensitivity of cisplatin towards cancer cells. The mitogen activated protein kinase (MAPK) pathway in the cell, consisting of extracellular signal regulated kinase, c-Jun N-terminal kinase, p38 kinases, and downstream mediator p90 ribosomal s6 kinase (RSK); is responsible for the regulation of various cellular events including cell survival, cell proliferation, cell cycle progression, cell migration and protein translation...
April 11, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29629833/aerobic-exercise-training-differentially-affects-ace-c-and-n-domain-activities-in-humans-interactions-with-ace-i-d-polymorphism-and-association-with-vascular-reactivity
#16
Cléber Rene Alves, Tiago Fernandes, José Ribeiro Lemos, Flávio de Castro Magalhães, Ivani Credidio Trombetta, Guilherme Barreto Alves, Glória de Fátima Alves da Mota, Rodrigo Gonçalves Dias, Alexandre Costa Pereira, José Eduardo Krieger, Carlos Eduardo Negrão, Edilamar Menezes Oliveira
INTRODUCTION: Previous studies have linked angiotensin-converting enzyme ( ACE) insertion (I)/deletion (D) polymorphism (II, ID and DD) to physical performance. Moreover, ACE has two catalytic domains: NH2 (N) and COOH (C) with distinct functions, and their activity has been found to be modulated by ACE polymorphism. The aim of the present study is to investigate the effects of the interaction between aerobic exercise training (AET) and ACE I/D polymorphism on ACE N- and C-domain activities and vascular reactivity in humans...
April 2018: Journal of the Renin-angiotensin-aldosterone System: JRAAS
https://www.readbyqxmd.com/read/29628341/the-human-cytomegalovirus-strain-db-activates-oncogenic-pathways-in-mammary-epithelial-cells
#17
Amit Kumar, Manoj Kumar Tripathy, Sébastien Pasquereau, Fatima Al Moussawi, Wasim Abbas, Laurie Coquard, Kashif Aziz Khan, Laetitia Russo, Marie-Paule Algros, Séverine Valmary-Degano, Olivier Adotevi, Stéphanie Morot-Bizot, Georges Herbein
BACKGROUND: Human cytomegalovirus (HCMV) establishes a persistent life-long infection and increasing evidence indicates HCMV infection can modulate signaling pathways associated with oncogenesis. Breast milk is an important route of HCMV transmission in humans and we hypothesized that mammary epithelial cells could be one of the main cellular targets of HCMV infection. METHODS: The infectivity of primary human mammary epithelial cells (HMECs) was assessed following infection with the HCMV-DB strain, a clinical isolate with a marked macrophage-tropism...
March 28, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29626979/placental-exosomes-profile-in-maternal-and-fetal-circulation-in-intrauterine-growth-restriction-liquid-biopsies-to-monitoring-fetal-growth
#18
Jezid Miranda, Cristina Paules, Soumyalekshmi Nair, Andrew Lai, Carlos Palma, Katherin Scholz-Romero, Gregory E Rice, Eduard Gratacos, Fatima Crispi, Carlos Salomon
INTRODUCTION: Placenta-derived exosomes may represent an additional pathway by which the placenta communicates with the maternal system to induce maternal vascular adaptations to pregnancy and it may be affected during Fetal growth restriction (FGR). The objective of this study was to quantify the concentration of total and placenta-derived exosomes in maternal and fetal circulation in small fetuses classified as FGR or small for gestational age (SGA). METHODS: Prospective cohort study in singleton term gestations including 10 normally grown fetuses and 20 small fetuses, sub-classified into SGA and FGR accordingly to birth weight (BW) percentile and fetoplacental Doppler...
April 2018: Placenta
https://www.readbyqxmd.com/read/29625942/lethal-toxic-dose-i-p-ld50-total-protein-contents-and-comparative-hemolytic-potential-of-99mtc-labeled-non-labeled-naja-naja-karachiensis-venom
#19
Muhammad Hassham Bin Asad, Arooj Fatima Asad, Sumbal Bibi, Kaleem Ullah, Tariq Javed, Majeed Ullah, Atif Ali, Ziaur Rahman Qureshi, Muhammad Imran Amirzada, Yasser Msa Al-Kahraman, Syed Muhammad Farid Hasan, Jean-Marc Sabatier, Albert Rizvanov
Recent recognition about snake bite envenomation on June, 2017 as neglected tropical disease under category-A by World Health Organization advocated again its undeniable importance. Present circumstances reasoned to work on a neglected subspecies of Naja naja, i.e., Naja naja karachiensis (N. n. karachensis) has been documented for frequent deaths in Pakistan. In this study median lethal toxic dose (LD50 ) was determined intraperitoneally in Swiss albino mice and was found to be 2.0µg/g (2.0mg/kg) equal in potency to Naja pallida (red spitting African cobra)...
March 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29622612/complete-genome-sequence-of-lactobacillus-plantarum-subsp-plantarum-strain-lb1-2-isolated-from-the-hindgut-of-european-honeybees-apis-mellifera-l-from-the-philippines
#20
M Fatima C Ilagan-Cruzada, Albert Remus R Rosana, Andrew D Montecillo, Noel G Sabino, Ida F Dalmacio
Lactobacillus plantarum subsp. plantarum strain LB1-2, isolated from the hindgut of European honeybees in the Philippines, is active against Paenibacillus larvae and has broad activity against several Gram-positive and Gram-negative bacteria. The complete genome sequence reported herein contains gene clusters for multiple bacteriocins and extensive gene inventories for carbohydrate metabolism.
April 5, 2018: Genome Announcements
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