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https://www.readbyqxmd.com/read/28319501/18f-fluorocholine-pet-ct-brain-mri-and-5-aminolevulinic-acid-for-the-assessment-of-tumor-resection-in-high-grade-glioma
#1
Ana María García Vicente, Fátima Jiménez Aragón, Maikal Villena Martín, German Andrés Jiménez Londoño, Jose María Borrás Moreno
High-grade glioma is a very aggressive and infiltrative tumor in which complete resection is a chance for a better outcome. We present the case of a 57-year-old man with a brain lesion suggestive of high-grade glioma. Brain MRI and F-fluorocholine PET/CT were performed previously to plan the surgery. Surgery was microscope assisted after the administration of 5-aminolevulinic acid. Postsurgery brain MRI and PET were blind evaluated to the surgery results and reported as probably gross total resection.
March 17, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28317570/oral-viral-infections-diagnosis-and-management
#2
REVIEW
Earl Clarkson, Fatima Mashkoor, Saif Abdulateef
This article focuses on common viral infections in the oral cavity with associated systemic manifestations. Discussed are the clinical features, histopathology, diagnosis, treatment, and prevention of viral infections in oral cavity. This will be a useful aid for general practitioners and other dental personnel wanting to expand their pathologic knowledge. This article discusses herpes simplex, varicella zoster, mononucleosis, cytomegalovirus, enteroviruses, rubeola, rubella, mumps, and human papillomavirus...
April 2017: Dental Clinics of North America
https://www.readbyqxmd.com/read/28317465/anti-cryptococcal-activity-of-ethanol-crude-extract-and-hexane-fraction-from-ocimum-basilicum-var-maria-bonita-mechanisms-of-action-and-synergism-with-amphotericin-b-and-ocimum-basilicum-essential-oil
#3
Nathalia N R Cardoso, Celuta S Alviano, Arie F Blank, Maria de Fátima Arrigoni-Blank, Maria Teresa V Romanos, Marcel M L Cunha, Antonio Jorge R da Silva, Daniela S Alviano
CONTEXT: Ocimum basilicum L. (Lamiaceae) has been used in folk medicine to treat headaches, kidney disorders, and intestinal worms. OBJECTIVE: This study evaluates the anti-cryptococcal activity of ethanol crude extract and hexane fraction obtained from O. basilicum var. Maria Bonita leaves. MATERIALS AND METHODS: The MIC values for Cryptococcus sp. were obtained according to Clinical and Laboratory Standards Institute in a range of 0.3-2500 μg/mL...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28316108/cry1a-b-16-toxin-from-bacillus-thuringiensis-theoretical-refinement-of-three-dimensional-structure-and-prediction-of-peptides-as-molecular-markers-for-detection-of-genetically-modified-organisms
#4
Alexandra Plácido, Andreia Coelho, Lucas Abreu do Nascimento, Andreanne Gomes Vasconcelos, Maria Fátima Barroso, Joilson Ramos-Jesus, Vladimir Costa, Francisco das Chagas Alves Lima, Cristina Delerue-Matos, Ricardo Martins Ramos, Mariela M Marani, José Roberto de Souza de Almeida Leite
Transgenic maize produced by the insertion of the Cry transgene into its genome became the second most cultivated crop worldwide. Cry gene from Bacillus thuringiensis kurstaki expresses protein derivatives of crystalline endotoxins which confer insect resistance onto the maize crop. Mandatory labeling of processed food containing or made by genetically modified organisms is in force in many countries, so, it is very urgent to develop fast and practical methods for GMO identification, e.g., biosensors. In the absence of an available empirical structure of Cry1A(b)16 protein, a theoretical model was effectively generated, in this work, by homology modeling and molecular dynamics simulations based on two available homologous protein structures...
March 18, 2017: Proteins
https://www.readbyqxmd.com/read/28314282/comparison-of-the-effects-of-monastrol-and-oxomonastrol-on-human-hepatoma-cell-line-hepg2-c3a
#5
Lilian Areal Marques, Simone Cristine Semprebon, Daniele Sartori, Ângelo DE Fátima, Lúcia Regina Ribeiro, Mário Sérgio Mantovani
Monastrol and its analog oxomonastrol differ by replacement of the sulfur atom present in monastrol to an oxygen atom in oxomonastrol. Monastrol inhibits the mitotic kinesin family member 11 (EG5), which has been studied for its potential use in cancer therapy. The aim of this study was to investigate the effect of monastrol and oxomonastrol on HepG2/C3A cells. Our results showed that monastrol induced DNA damage, reduced cell proliferation, and up-regulated the cytochrome P450 family 1 subfamily A member 1 (CYP1A1) mRNA levels...
March 2017: Anticancer Research
https://www.readbyqxmd.com/read/28304352/in-vitro-anti-inflammatory-and-cytotoxic-effects-of-aqueous-extracts-from-the-edible-sea-anemones-anemonia-sulcata-and-actinia-equina
#6
Tânia Costa Silva, Paula Branquinho de Andrade, Fátima Paiva-Martins, Patrícia Valentão, David Micael Pereira
Marine invertebrates have been attracting the attention of researchers for their application in nutrition, agriculture, and the pharmaceutical industry, among others. Concerning sea anemones (Cnidaria), little is known regarding their metabolic profiles and potential value as a source of pharmacologically-active agents. In this work, the chemical profiles of two species of sea anemones Actinia equina and Anemonia sulcata, were studied by high-performance liquid chromatography with diode-array detection (HPLC-DAD) and its impact upon immune and gastric cells was evaluated...
March 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28304013/loop-mediated-isothermal-amplification-tb-lamp-a-step-forward-in-the-diagnosis-of-tuberculosis
#7
Hanieya Saiyed, Sarosh Fatima
No abstract text is available yet for this article.
March 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28304002/influence-of-free-drug-samples-on-prescribing-by-physicians-a-cross-sectional-survey
#8
Samina Rafique, Waseem Sarwar, Asima Rashid, Fatima Sheerin
Free drug samples are distributed among doctors as a promotional tool. We investigated the effects of dispensing samples on prescriptions by the doctors and their opinion about samples through a cross-sectional survey. A questionnaire was distributed among the doctors in the Department of Medicine, Nishtar Hospital Multan. It contained drug choices for two hypothetical scenarios, options and reasons for using free samples and doctors' views about them. Response rate remained 83% (166/198). In scenario 1 (rheumatoid arthritis), 100 % and in scenario 2 (acid peptic disease), 13% of sample users dispensed against their preference while in both cases 78 % prescribed the same brand afterwards...
March 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28302562/dysregulated-expression-of-microrna-150-in-human-papillomavirus-induced-lesions-of-k14-hpv16-transgenic-mice
#9
Joana M O Santos, Mara Fernandes, Rita Araújo, Hugo Sousa, Joana Ribeiro, Margarida M S M Bastos, Paula A Oliveira, Diogo Carmo, Fátima Casaca, Sandra Silva, Ana L Teixeira, Rui M Gil da Costa, Rui Medeiros
AIMS: High-risk human papillomavirus (HPV) infection is one of the major causes of infection-related cancers worldwide. MicroRNAs (miRNAs) are a family of non-coding RNAs (ncRNAs), whose dysregulated levels may cause an aberrant expression of genes involved in oncogenic pathways and consequently lead to cancer development. This is the case of the miRNA-150 (miR-150), whose expression in HPV-induced lesions remains unclear and the present work aims to clarify it. We employed K14-HPV16 mice, which express the early genes of HPV16 in basal keratinocytes, leading to the development of hyperplastic and dysplastic skin lesions and squamous cell carcinomas, and are a representative model of HPV-induced cancers...
March 13, 2017: Life Sciences
https://www.readbyqxmd.com/read/28302390/matching-pairs-difficulty-in-children-with-spinal-muscular-atrophy-type-i
#10
Graziela Jorge Polido, Alessandra Ferreira Barbosa, Carlos Hitoshi Morimoto, Fátima Aparecida Caromano, Francis Meire Favero, Edmar Zanoteli, Umbertina Conti Reed, Mariana Callil Voos
This study aimed to investigate the performance on pair-matching tasks in children with Spinal Muscular Atrophy type I (SMA-I) and the relationship between this performance and motor function, functional independence and quality of life. SMA-I (n = 12; 6.0 ± 2.3 yrs; 9 boys, 3 girls) and control sex-, age-matched children (n = 12; 6.2 ± 2.6 yrs) performed four pair-matching figure, number and letter tasks. The eye tracker detected eye movements. SMA-I children were assessed with CHOP INTEND, Pediatric Evaluation of Disability Inventory, and Pediatric Quality of Life Inventory...
February 15, 2017: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/28301553/multiplex-pcr-as-a-tool-for-the-diagnosis-of-leishmania-spp-kdna-and-the-gapdh-housekeeping-gene-of-mammal-hosts
#11
Renata de Cássia-Pires, Myllena de Fátima Alheiros Dias de Melo, Raquel da Hora Barbosa, André Luiz Rodrigues Roque
BACKGROUND: The PCR assays usually employed for Leishmania diagnosis does not simultaneously detect a constitutive gene that would certify the viability of the DNA sample. We present a multiplex PCR approach for the simultaneous diagnosis of the Leishmania sp. kDNA fragment and a catalytic domain segment of a conserved region of the mammalian gapdh gene. METHODOLOGY: The proposed multiplex protocol was designed through in silico PCR. The annealing temperature, concentration of primer pairs, number of cycles, distinct polymerase enzymes and premix kit were defined to achieve an optimal reaction...
2017: PloS One
https://www.readbyqxmd.com/read/28301493/obstetrician-s-risk-perception-on-the-prescription-of-magnesium-sulfate-in-severe-preeclampsia-and-eclampsia-a-qualitative-study-in-brazil
#12
Fátima Aparecida Lotufo, Mary Angela Parpinelli, Maria José Osis, Fernanda Garanhani Surita, Maria Laura Costa, José Guilherme Cecatti
INTRODUCTION: Magnesium sulfate (MgSO4) is the drug of choice for the prevention and control of seizures in the management of severe preeclampsia/eclampsia. Several barriers have been identified in the use of MgSO4, especially in low and middle-income settings. OBJECTIVE: To describe the obstetrician's perception on possible reasons for underutilizing magnesium sulfate to treat preeclampsia/eclampsia. METHOD: A qualitative clinical study, based on phenomenological reference by semi-structured interviews and open-ended discussions with obstetricians of the public healthcare system in primary care units (PCU) and referral maternity hospitals (RMH), in a southeastern Brazilian city...
2017: PloS One
https://www.readbyqxmd.com/read/28301065/dinuclear-crown-ether-palladium-complex-a-highly-effective-strategy-for-encapsulating-potassium-cations-in-small-crown-ether-rings
#13
Jose M Vila, Fatima Lucio-Martinez, Brais Bermudez, Juan Ortigueira, Harry Adams, M Teresa Pereira, Alberto Fernandez
The potential of 15-crown-5 ethers to link rather large cations as potassium is limited to the quasi parallel arrangement of two oxygen donor moieties upon appropriate orientation of the corresponding ether ring containing molecules. Substrates bearing the two crown ethers capable of achieving such coordination are hitherto unknown. The synthesis and isolation of a tailored-made dinuclear palladacycle bearing 15-crown-5 ether rings on the metallated phenyls offers such a possibility providing the adequate environment for the formation of the sandwiched [K(metalacycle-15-crown-5)2] moiety...
March 16, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28301035/comparison-among-the-efficacy-of-interventions-for-the-return-rate-to-receive-the-pap-test-report-randomized-controlled-clinical-trial
#14
Camila Teixeira Moreira Vasconcelos, Ana Karina Bezerra Pinheiro, Ana Izabel Oliveira Nicolau, Thaís Marques Lima, Denise de Fátima Fernandes Barbosa
Objective: to test the effects of a behavioral, an educative and a comparative intervention on women's adherence to the return appointment to receive the pap test report. Methods: randomized controlled clinical trial at a Primary Health Care Service, involving three groups: EG (educative session and test demonstration), BG (recall ribbon) and standard intervention (card containing the return appointment - graphical reminder), called comparative group here (CG). To select the sample, the following was established: having started sexual activity and undergoing the pap smear during the study, resulting in 775 women...
March 2, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28300999/quality-of-life-and-characteristics-of-diabetic-patients
#15
Karina Corrêa, Giovana Renata Gouvêa, Marco Antonio Viera da Silva, Rosana de Fátima Possobon, Luis Fernando de Lima Nunes Barbosa, Antonio Carlos Pereira, Luciane Guerra Miranda, Karine Laura Cortellazzi
This study aimed to assess the association between quality of life and clinical and sociodemographic variables in type 2 diabetes patients, after they had started treatment in Primary and Specialized Health Care. This is an analytical cross-sectional study with a sampling of diabetic patients from Primary (n = 385) and Specialized (n = 385) Health Care. The dependent variable, quality of life, was evaluated by the Diabetes Quality of Life Measure - Brazil. Clinical and sociodemographic data were collected. Bivariate analysis by chi square test tested the association between the dependent variable with the independent ones...
March 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28300989/analysis-of-the-performance-of-contractualization-primary-health-care-indicators-in-the-period-2009-2015-in-lisbon-and-tagus-valley
#16
Baltazar Ricardo Monteiro, Fátima Candoso, Magda Reis, Sónia Bastos
Reforms started in 1996 intended that Regional Health Administrations (ARS) should play a relevant role in the process of transforming an integrated model towards a contractual health care model. The essential tool of this transformation would be the Contractualization Agency, established in each ARS. Its role in the new contractualization culture was to negotiate prospective budgets with health care institutions, which included Primary Health Care (PHC). This paper is a longitudinal analysis of the development of a set of nine PHC contractualization indicators in three Health Center Clusters (ACeS) of the Regional Health Administration of Lisbon and Tagus Valley (ARSLVT)...
March 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28300982/primary-healthcare-in-portugal-10-years-of-contractualization-of-health-services-in-the-region-of-lisbon
#17
Baltazar Ricardo Monteiro, Ana Maria Silva Azenha Pisco, Fátima Candoso, Sónia Bastos, Magda Reis
Contractualization consists in the development and implementation of a documented agreement whereby one party (payer) provides compensation to the other party (provider) in exchange for a set of health services to a targeted population. We describe, through a case study, the history and the process of implementation of primary health care contractualization (since 1992) in Portugal, emphasizing the consolidation and future challenges of the primary healthcare reform started in 2005. This article resorts to a case study to reflect on the results obtained in the Cluster of Health Centers of the Northern West, Regional Administration of Lisbon and Tagus Valley, between 2009 and 2015, following implementation of contractualization...
March 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28300873/the-renoprotective-effect-of-oral-tadalafil-pretreatment-on-ischemia-reperfusion-injury-in-rats
#18
Vanessa de Fátima Lima Paiva Medeiros, Ítalo Medeiros Azevedo, Marília Daniela Ferreira Carvalho, Cláudia Nunes Oliveira, Eryvaldo Sócrates Tabosa do Egito, Aldo Cunha Medeiros
To evaluate the effect of tadalafil in renal ischemia/reperfusion (I/R) injury in rats Methods: Group I/R saline rats (n=6) were subjected to 45 minutes of left renal ischemia and treated with saline; the I/R tadalafil rats (n=6) received oral 10mg/kg tadalafil microemulsion one hour before ischemia. In both groups, 8 hours after ischemia, laboratory analysis were performed Results: Better tissue perfusion was lower in ischemic left/kidney than in right/kidney in saline group, suggesting reduced kidney clearance...
February 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28300606/one-step-multiplex-rt-qpcr-detects-three-citrus-viroids-from-different-genera-in-a-wide-range-of-hosts
#19
Fatima Osman, Tyler Dang, Sohrab Bodaghi, Georgios Vidalakis
A one-step multiplex reverse transcription real-time quantitative polymerase chain reaction (RT-qPCR) based on species-specific minor groove binding (MGB) probes, was developed for the simultaneous detection, identification, and quantification of three citrus viroids belonging to different genera. Citrus exocortis viroid (Pospiviroid), Hop stunt viroid (Hostuviroid), and Citrus bark cracking viroid (Cocadviroid) cause a variety of maladies in agriculturally significant crops. Therefore, reliable assays for their detection are essential tools for various government and industry organizations implementing disease management programs...
March 11, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28299396/no-correlation-between-mthfr-c-677-c%C3%A2-%C3%A2-t-mthfr-c-1298-a%C3%A2-%C3%A2-c-and-abcb1-c-3435-c%C3%A2-%C3%A2-t-polymorphisms-and-methotrexate-therapeutic-outcome-of-rheumatoid-arthritis-in-west-algerian-population
#20
Wefa Boughrara, Ahmed Benzaoui, Meriem Aberkane, Fatima Zohra Moghtit, Samia Dorgham, Aicha Sarah Lardjam-Hetraf, Hadjer Ouhaibi-Djellouli, Elisabeth Petit Teixeira, Abdallah Boudjema
CONTEXT: The c.677 C > T and c.1298 A > C polymorphisms of methylenetatrahydrofolate reductase (MTHFR) gene and c.3435 C > T polymorphism of ATP-Binding cassette B1 (ABCB1) gene are reported as pharmacogenetic markers, influencing the methotrexate (MTX) therapeutic outcome in rheumatoid arthritis (RA) patients. OBJECTIVES: The aims of this study were to determine the relationship between these polymorphisms and clinical response and/or adverse drug reaction (ADRs) to MTX treatment...
March 15, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
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