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https://www.readbyqxmd.com/read/29049914/t-2-toxin-induces-cytotoxicity-and-disrupts-tight-junction-barrier-in-serw3-cells
#1
Elif Karacaoğlu, Güldeniz Selmanoğlu
T-2 toxin, which is produced in grain and grain products as a secondary metabolite by Fusarium species, is also potentially dangerous for human health. Up to date, no study was reported the cytotoxicity of T-2 toxin on SerW3 cells in the perspective of junctional barriers. This study focused on revealing the cytotoxic effects of T-2 on Sertoli cells associated with cell junctional barriers. In the present study, SerW3 cells were exposed to T-2 toxin at 12, 120 and 1200ng/ml doses for 24 and 48h. Cytotoxicity tests including cell viability (MTT), lactate dehydrogenase (LDH) cytotoxicity test and trypan blue exclusion assay were performed...
October 12, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29047514/evaluation-of-adaptively-enhanced-two-shot-fringe-pattern-phase-and-amplitude-demodulation-methods
#2
Dominika Saide, Maciej Trusiak, Krzysztof Patorski
Phase-shifting interferometry is a standard tool in optical metrology. Most frequently, it needs three or more interferograms to solve the system of fringe equations for phase or amplitude retrieval, which limits its time resolution. Recently, the topic of two-shot, arbitrary-phase-step fringe pattern phase and amplitude demodulation has been flourishing and attracting attention with several novel and interesting methods being proposed. In this work, we evaluate six up-to-date two-shot phase-shifting methods analyzing their main error sources and proposing efficient ways to minimize their influence by adaptive filtering using the Hilbert-Huang transform...
July 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/29047393/the-human-behaviour-change-project-harnessing-the-power-of-artificial-intelligence-and-machine-learning-for-evidence-synthesis-and-interpretation
#3
Susan Michie, James Thomas, Marie Johnston, Pol Mac Aonghusa, John Shawe-Taylor, Michael P Kelly, Léa A Deleris, Ailbhe N Finnerty, Marta M Marques, Emma Norris, Alison O'Mara-Eves, Robert West
BACKGROUND: Behaviour change is key to addressing both the challenges facing human health and wellbeing and to promoting the uptake of research findings in health policy and practice. We need to make better use of the vast amount of accumulating evidence from behaviour change intervention (BCI) evaluations and promote the uptake of that evidence into a wide range of contexts. The scale and complexity of the task of synthesising and interpreting this evidence, and increasing evidence timeliness and accessibility, will require increased computer support...
October 18, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/29045755/the-triforc-database-a-comprehensive-up-to-date-resource-of-plant-triterpene-biosynthesis
#4
Karel Miettinen, Sabrina Iñigo, Lukasz Kreft, Jacob Pollier, Christof De Bo, Alexander Botzki, Frederik Coppens, S Ren Bak, Alain Goossens
Triterpenes constitute a large and important class of plant natural products with diverse structures and functions. Their biological roles range from membrane structural components over plant hormones to specialized plant defence compounds. Furthermore, triterpenes have great potential for a variety of commercial applications such as vaccine adjuvants, anti-cancer drugs, food supplements and agronomic agents. Their biosynthesis is carried out through complicated, branched pathways by multiple enzyme types that include oxidosqualene cyclases, cytochrome P450s, and UDP-glycosyltransferases...
October 17, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29045284/increasing-colorectal-cancer-screening-using-a-quality-improvement-approach-in-a-nurse-managed-primary-care-clinic
#5
Diane Hountz, Jennifer Coddington, Karen J Foli, Janet Thorlton
According to the American Cancer Society, 1 in 23 Americans will be diagnosed with colorectal cancer (CRC) in their lifetime. Screening for CRC is an effective, yet underused preventive approach. This is especially true in rural areas, where only 35% of patients were found to be up to date on their screenings in 2014. Increasing CRC screening can produce positive patient outcomes by early recognition and removal of precancerous polyps. The purpose of this project was to use quality improvement (QI) interventions to increase CRC screening rates at a nurse-managed clinic in rural Indiana...
October 17, 2017: Journal for Healthcare Quality: Official Publication of the National Association for Healthcare Quality
https://www.readbyqxmd.com/read/29043418/lung-magnetic-resonance-imaging-for-pneumonia-in-children
#6
REVIEW
Mark C Liszewski, Süreyya Görkem, Kushaljit S Sodhi, Edward Y Lee
Technical factors have historically limited the role of MRI in the evaluation of pneumonia in children in routine clinical practice. As imaging technology has advanced, recent studies utilizing practical MR imaging protocols have shown MRI to be an accurate potential alternative to CT for the evaluation of pneumonia and its complications. This article provides up-to-date MR imaging techniques that can be implemented in most radiology departments to evaluate pneumonia in children. Imaging findings in pneumonia on MRI are also reviewed...
October 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/29040783/patient-exposure-from-nuclear-medicine-in-france-national-follow-up-and-influence-of-the-technology-through-diagnostic-reference-levels-data-analysis
#7
Patrice Roch, David Celier, Cécile Dessaud, Cécile Etard
The Nuclear Safety and Radiation Protection French Institute (IRSN) presents its latest assessment from up-to-date diagnostic reference levels (DRL) national data in nuclear medicine (NM). NM departments annually send data to IRSN to estimate the representativeness of current DRLs. Complementary analyses of the data have been performed to evaluate the influence of equipment evolution on practice and patient radiation exposure. Based on data from almost 90% of the French NM departments, some DRL update are proposed...
October 13, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29039839/-the-role-of-integrated-assessment-of-the-indicators-of-external-respiration-function-in-cardiac-surgical-patients
#8
O V Kamenskaja, A S Klinkova, I Ju Loginova, V V Lomivorotov, D N Ponomarev, D V Habarov, V N Lomivorotov
This literature review dedicated to the importance of an integrated assessment of external respiratory function in cardiovascular diseases (CVDs), including an analysis of up-to-date techniques, such as spirometry, body plethysmography, examination of the diffusing capacity of the lung, determination of O2 consumption with evaluation of the effectiveness of pulmonary ventilation. It considers the pathogenetic components of impairments in pulmonary ventilation and gas exchange, which develop in different CVDs, as well as during and after cardiac surgery...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/29038992/-soft-tissue-sarcoma-how-can-posttreatment-alterations-be-distinguished-from-recurrences
#9
REVIEW
I-M Noebauer-Huhmann, T Grieser
The recognition of recurrent soft tissue sarcomas and the differentiation from post-treatment alterations is complex. This article aims to assist the clinical radiologist in the systematic evaluation of local follow-up imaging in soft tissue sarcoma patients. Soft tissue sarcomas encompass multiple entities with different recurrence rates and follow-up intervals. Approved and up to date recommendations are provided, including imaging techniques. The past medical history of the patient, the clinical situation and previous therapies should be known in detail, including surgery, radiation therapy and chemotherapy...
October 16, 2017: Der Radiologe
https://www.readbyqxmd.com/read/29038189/nodular-pulmonary-amyloidosis-a-complex-disease-with-malignancy-association
#10
Jacob M Core, Ali A Alsaad, Liuyan Jiang, Neal M Patel
Pulmonary amyloidosis is a rare disease that incorporates deposition of amyloid microfibril material in the lung parenchyma. The condition generally presents as an indolent subacute-to-chronic pulmonary disease and requires tissue biopsy to establish the diagnosis. Nodular pulmonary amyloidosis, a subtype of pulmonary amyloidosis, is characterised by special radiographic and pathological features. While the disease can be associated with inflammatory conditions; its association with mucosal-associated lymphoid tissue (MALT lymphoma) is unusual and carries management challenges...
October 15, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29037898/zika-virus-and-autoimmunity-one-step-forward
#11
REVIEW
Diana M Monsalve, Yovana Pacheco, Yeny Acosta-Ampudia, Yhojan Rodríguez, Carolina Ramírez-Santana, Juan-Manuel Anaya
Zika virus (ZIKV) infection has been associated with the development of Guillain-Barré syndrome (GBS) and idiopathic thrombocytopenic purpura (ITP). Whether ZIKV infection is related to other autoimmune diseases is unknown. Therefore, an association study to evaluate rheumatic and thyroid autoimmunity in patients with ZIKV disease was conducted through a panel of 14 autoantibodies. In addition, a literature review on ZIKV, and GBS and ITP was performed. Our results disclosed a lack of rheumatoid and thyroid autoimmunity in patients with ZIKV disease...
October 13, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29037277/development-and-preliminary-validation-of-the-physician-support-of-skin-self-examination-scale
#12
Adina Coroiu, Chelsea Moran, Rosalind Garland, Annett Körner
Skin self-examination (SSE) is a crucial preventive health behaviour in melanoma survivors, as it facilitates early detection. Physician endorsement of SSE is important for the initiation and maintenance of this behaviour. This study focussed on the preliminary validation of a new nine-item measure assessing physician support of SSE in melanoma patients. English and French versions of this measure were administered to 188 patients diagnosed with melanoma in the context of a longitudinal study investigating predictors and facilitators of SSE...
October 17, 2017: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/29037237/the-role-of-national-registries-in-improving-patient-safety-for-hip-and-knee-replacements
#13
Anne Lübbeke, Alan J Silman, Daniel Prieto-Alhambra, Amanda I Adler, Christophe Barea, Andrew J Carr
BACKGROUND: The serious adverse events associated with metal on metal hip replacements have highlighted the importance of improving methods for monitoring surgical implants. The new European Union (EU) device regulation will enforce post-marketing surveillance based on registries among other surveillance tools. Europe has a common regulatory environment, a common market for medical devices, and extensive experience with joint replacement registries. In this context, we elaborate how joint replacement registries, while building on existing structure and data, can better ensure safety and balance risks and benefits...
October 16, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29036916/recent-progresses-and-development-of-advanced-atomic-layer-deposition-towards-high-performance-li-ion-batteries
#14
REVIEW
Wei Lu, Longwei Liang, Xuan Sun, Xiaofei Sun, Chen Wu, Linrui Hou, Jinfeng Sun, Changzhou Yuan
Electrode materials and electrolytes play a vital role in device-level performance of rechargeable Li-ion batteries (LIBs). However, electrode structure/component degeneration and electrode-electrolyte sur-/interface evolution are identified as the most crucial obstacles in practical applications. Thanks to its congenital advantages, atomic layer deposition (ALD) methodology has attracted enormous attention in advanced LIBs. This review mainly focuses upon the up-to-date progress and development of the ALD in high-performance LIBs...
October 14, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29034827/dealing-with-a-changing-work-environment-hospital-job-type-contingencies
#15
Jasmijn van Harten, Eva Knies, Peter Leisink
Purpose The purpose of this paper is twofold: first, to examine whether workers in various hospital job groups differ in their perceptions of the provision of managerial support, and of their up-to-date expertise (UDE), willingness to change (WTC) and employment opportunities (EO). Second, to examine whether and how the relationships between managerial support, workers' UDE, WTC and their EO are moderated by hospital job type. Design/methodology/approach Survey data were collected from 1,764 employees of three Dutch hospitals...
September 18, 2017: Journal of Health Organization and Management
https://www.readbyqxmd.com/read/29034191/pharmacological-properties-of-salvia-officinalis-and-its-components
#16
Ahmad Ghorbani, Mahdi Esmaeilizadeh
Salvia officinalis (Sage) is a plant in the family of Labiatae/Lamiaceae. It is native to Middle East and Mediterranean areas, but today has been naturalized throughout the world. In folk medicine, S. officinalis has been used for the treatment of different kinds of disorders including seizure, ulcers, gout, rheumatism, inflammation, dizziness, tremor, paralysis, diarrhea, and hyperglycemia. In recent years, this plant has been a subject of intensive studies to document its traditional use and to find new biological effects...
October 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29033394/diagnostic-biomarkers-for-lung-cancer-prevention
#17
Roberto Gasparri, Rosalia Romano, Giulia Sedda, Alessandro Borri, Francesco Petrella, Domenico Galetta, Monica Casiraghi, Lorenzo Spaggiari
Lung cancer is the leading cause of death for neoplasm. The lung cancer mortality is frequently associated with late diagnosis, therefore an early diagnosis is a key factor to significantly improve overall survival in high risk populations of asymptomatic patients. Conventional cancer screenings (low-dose computed tomography or chest x-ray) today offers early detection but are invasive and expensive. Up to date these studies evaluated the solid and topographic cancer structure and morphology. Today the concept of tumor has been remodeled and it has been defined as a disease that has its own genetic, biological and metabolic identity and on this new awareness we should base the new screening methods...
October 16, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29033034/antimicrobial-resistance-among-children-in-sub-saharan-africa
#18
REVIEW
Phoebe C M Williams, David Isaacs, James A Berkley
Antimicrobial resistance is an important threat to international health. Therapeutic guidelines for empirical treatment of common life-threatening infections depend on available information regarding microbial aetiology and antimicrobial susceptibility, but sub-Saharan Africa lacks diagnostic capacity and antimicrobial resistance surveillance. We systematically reviewed studies of antimicrobial resistance among children in sub-Saharan Africa since 2005. 18 of 1075 articles reviewed met inclusion criteria, providing data from 67 451 invasive bacterial isolates from inconsistently defined populations in predominantly urban tertiary settings...
October 9, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29032502/gut-microbiota-changes-in-the-extreme-decades-of-human-life-a-focus-on-centenarians
#19
REVIEW
Aurelia Santoro, Rita Ostan, Marco Candela, Elena Biagi, Patrizia Brigidi, Miriam Capri, Claudio Franceschi
The gut microbiota (GM) is a complex, evolutionarily molded ecological system, which contributes to a variety of physiological functions. The GM is highly dynamic, being sensitive to environmental stimuli, and its composition changes over the host's entire lifespan. However, the basic question of how much these changes may be ascribed to variables such as population, diet, genetics and gender, and/or to the aging process per se is still largely unanswered. We argue that comparison among studies on centenarians-the best model of healthy aging and longevity-recruited from different geographical areas/populations (different genetics and dietary habits) can help to disentangle the contribution of aging and non-aging-related variables to GM remodeling with age...
October 14, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29031291/metal-speciation-analysis-of-petroleum-myth-or-reality
#20
REVIEW
Tatyana A Maryutina, Andrei R Timerbaev
Metals occurring in crude oil in a great variety of complexed forms are minor but important constituents as they affect the refining and production operations, as well as participate in geochemical processes. These roles of metals are thought to be related to their chemical state the knowledge of which requires performing speciation analysis. While exact metal speciation in crude oil still remains obscure, earnest efforts to decipher it based on using up-to-date hyphenated techniques have been attempted in the past decade...
October 23, 2017: Analytica Chimica Acta
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