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https://www.readbyqxmd.com/read/28346011/various-plus-unique-viral-protein-u-as-a-plurifunctional-protein-for-hiv-1-replication
#1
Andrew Soper, Guillermo Juarez-Fernandez, Hirofumi Aso, Miyu Moriwaki, Eri Yamada, Yusuke Nakano, Yoshio Koyanagi, Kei Sato
Human immunodeficiency virus type 1 (HIV-1), the causative agent of acquired immunodeficiency syndrome, encodes four accessory genes, one of which is viral protein U (Vpu). Recently, the study of Vpu has been of great interest. For instance, various cellular proteins are degraded (e.g. CD4) and down-modulated (e.g. tetherin) by Vpu. Vpu also antagonizes the function of tetherin and inhibits NF-κB. Moreover, Vpu is a viroporin forming ion channels and may represent a promising target for anti-HIV-1 drugs. In this review, we summarize the domains/residues that are responsible for Vpu's functions, describe the current understanding of the role of Vpu in HIV-1-infected cells, and review the effect of Vpu on HIV-1 in replication and pathogenesis...
April 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28344855/changes-in-colorectal-cancer-screening-knowledge-behavior-beliefs-self-efficacy-and-barriers-among-community-health-clinic-patients-after-a-health-literacy-intervention
#2
Connie L Arnold, Alfred Rademaker, Dachao Liu, Terry C Davis
OBJECTIVE: The objective in this pre- and post-survey assessment was to compare the effectiveness of a health literacy-directed intervention designed to increase knowledge, beliefs, barriers, self-efficacy and behavior associated with CRC screening with FOBT among patients cared for in predominantly rural community clinics and the change in these characteristics over the first 15 months after enrolling in a study designed to assess screening strategies. METHODS: Between 2008 and 2011, a quasi-experimental intervention was conducted in 8 predominantly rural Federally Qualified Health Centers...
February 2017: Journal of Community Medicine & Health Education
https://www.readbyqxmd.com/read/28344749/heavily-calcified-gastrointestinal-stromal-tumors-pathophysiology-and-implications-of-a-rare-clinicopathologic-entity
#3
Massimiliano Salati, Giulia Orsi, Luca Reggiani Bonetti, Fabrizio Di Benedetto, Giuseppe Longo, Stefano Cascinu
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract, and are characterized by a broad spectrum of clinical, histological and molecular features at presentation. Although focal and scattered calcifications are not uncommon within the primary tumor mass, heavy calcification within a GIST is rarely described in the literature and the clinical-biological meaning of this feature remains unclear. Cases with such an atypical presentation are challenging and may be associated with diagnostic pitfalls...
March 15, 2017: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28343206/-euthanasia-an-attempt-to-organize-issue
#4
Tomasz Kirmes, Mateusz Wilk, Czesław Chowaniec
This article is an attempt to complete and holistically discuss problem of euthanasia, especially its ethical and legal aspects, comparing to Polish law. The subject of euthanasia arouse interest of the society because it touches one of the most important aspects of life, which is the death. Even bigger emotions are aroused amongst physicians. They are forced to put on the line the life as biggest value on the one side and autonomy of human being on the other. It also touches the empathy for suffering. The euthanasia was divided into three forms: active euthanasia, passive euthanasia and assisted suicide...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28343200/sentinel-lymph-node-sln-in-breast-cancer-review-of-current-identification-methods
#5
Andrzej Lorek, Agnieszka Boratyn-Nowicka, Ewa Szlachta-Światkowska
The subject of the paper is the review of the current methods for identifying the sentinel lymph node in breast cancer treatment, taking into account the latest techniques and based on the up-to-date analyses of many years of experience in using this method.
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28340692/calr-gene-mutational-profile-in-myeloproliferative-neoplasms-with-non-mutated-jak2-in-moroccan-patients-a-case-series-and-germline-in-frame-deletion
#6
W Smaili, Y Doubaj, F Z Laarabi, J Lyahyai, M Kerbout, M Mikdame, A Sefiani
BACKGROUND: The discovery of somatic mutations within the gene encoding calreticulin (CALR) in 2013 represented a major milestone in the molecular diagnosis of BCR-ABL negative myeloproliferative neoplasms (MPN). In fact, exome sequencing revealed that most patients with essential thrombocythemia (ET) or primary myelofibrosis (PMF) lacking JAK2 or MPL mutations, harbor somatic insertion and/or deletion in exon 9 of CALR gene. In this study, we identified the first CALR gene mutational landscape in Moroccan patients with MPN nonmutated for the JAK2 gene...
January 2017: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/28338802/cross-species-genome-wide-identification-of-evolutionary-conserved-microproteins
#7
Daniel Straub, Stephan Wenkel
MicroProteins are small single-domain proteins that act by engaging their targets into different, sometimes non-productive protein complexes. In order to identify novel microProteins in any sequenced genome of interest, we have developed miPFinder, a program that identifies and classifies potential microProteins. In the past years, several microProteins have been discovered in plants where they are mainly involved in the regulation of development by fine-tuning transcription factor activities. The miPFinder algorithm identifies all up to date known plant microProteins and extends the microProtein concept beyond transcription factors to other protein families...
March 2, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28338345/challenges-and-driving-forces-for-business-plans-in-biobanking
#8
Tanja Macheiner, Berthold Huppertz, Michaela Bayer, Karine Sargsyan
BACKGROUND: Due to increased utilization of biospecimens for research and emergence of new technologies, the availability and quality of biospecimens and their collection are coming more and more into focus. However, the long-term economic situation of biobanks is still mostly unclear. Also, the common sustainable utilization of various international biobanks is challenging due to local differences in sample processing, law and ethics. AIM: This article discusses possible strategies to achieve a sustainable utilization of biospecimens as part of the business plan of biobanks...
March 24, 2017: Biopreservation and Biobanking
https://www.readbyqxmd.com/read/28337384/topoisomerase-i-top1-a-major-target-of-fl118-for-its-antitumor-efficacy-or-mainly-involved-in-its-side-effects-of-hematopoietic-toxicity
#9
EDITORIAL
Fengzhi Li, Xiang Ling, Danni L Harris, Jianqun Liao, Yuping Wang, David Westover, Guohui Jiang, Bo Xu, Patrick M Boland, Chunyang Jin
FL118 is a novel camptothecin (CPT) analogue that possesses exceptional antitumor efficacy in human tumor animal models. To date, two CPT analogues, irinotecan and topotecan, have been approved by the FDA for cancer treatment. FL118 exhibits superior antitumor activity over irinotecan and topotecan, and effectively overcomes the irinotecan- or topotecan-resistant human tumors in animal models. Accordingly, FL118 selectively inhibits the expression of multiple cancer-associated proteins (survivin, Mcl-1, XIAP, cIAP2, MdmX)...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28336746/understanding-dutch-practice-nurses-adherence-to-evidence-based-smoking-cessation-guidelines-and-their-needs-for-web-based-adherence-support-results-from-semistructured-interviews
#10
D de Ruijter, E S Smit, H de Vries, L Goossens, C Hoving
OBJECTIVES: Practice nurses in general practices suboptimally adhere to smoking cessation guidelines. Since the effectiveness of their smoking cessation support is greatest when full adherence to these guidelines is achieved, interventions need to be developed to improve practice nurses' guideline adherence, for example, by tailoring their content to adherence determinants. However, the sociocognitive determinants explaining adherence have not yet been investigated. Therefore, this qualitative needs assessment aimed to explore practice nurses' current counselling practices, as well as their sociocognitive beliefs related to their smoking cessation guideline adherence and their needs regarding web-based adherence support...
March 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/28336374/developments-and-future-clinical-outlook-of-taxane-nanomedicines
#11
REVIEW
Benoit Louage, Olivier De Wever, Wim E Hennink, Bruno G De Geest
Taxanes are highly valuable drugs for cancer treatment. Low water-solubility however puts a major challenge in obtaining formulations that are stable and easy-to-use in clinical practice. Initially, solubilization and lowering toxicity of taxanes has been the main research focus. However, emerging passive and active targeting strategies, especially in the field of nanomedicine, have been capital incentives to further broaden therapeutic index by improving efficacy. This review provides an up-to-date clinical track record of taxane nanomedicines in view of the current state-of-the-art in anti-cancer drug delivery...
March 20, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28336077/out-of-hospital-cardiac-arrest-concise-review-of-strategies-to-improve-outcome
#12
REVIEW
Richard J Jabbour, Sayan Sen, Ghada W Mikhail, Iqbal S Malik
Despite decades of research, cardiac arrest remains a major cause of morbidity and mortality, with frustratingly poor survival rates of approximately 10% to hospital discharge. Various strategies have been shown to improve survival, but differing degrees of implementation have led to a disparity in survival rates. These improvements, however, are balanced against the increasing age of patients presenting with out of hospital cardiac arrest and decreasing incidence of ventricular fibrillation, the rhythm with the best outcome...
March 15, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28335820/exploring-the-tensions-of-being-and-becoming-a-medical-educator
#13
Ahsan Sethi, Rola Ajjawi, Sean McAleer, Susie Schofield
BACKGROUND: Previous studies have identified tensions medical faculty encounter in their roles but not specifically those with a qualification in medical education. It is likely that those with postgraduate qualifications may face additional tensions (i.e., internal or external conflicts or concerns) from differentiation by others, greater responsibilities and translational work against the status quo. This study explores the complex and multi-faceted tensions of educators with qualifications in medical education at various stages in their career...
March 23, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28333534/effects-of-multisystemic-therapy-on-caregivers-of-serious-juvenile-offenders-a-20-year-follow-up-to-a-randomized-clinical-trial
#14
Benjamin D Johnides, Charles M Borduin, David V Wagner, Alex R Dopp
OBJECTIVE: Caregivers of serious juvenile offenders often hold favorable attitudes about criminality and frequently have histories of involvement in antisocial behaviors themselves. In the present study, the authors examined the long-term criminal and noncriminal outcomes for caregivers of serious juvenile offenders who had participated two decades earlier in a randomized clinical trial of multisystemic therapy (MST; Borduin et al., 1995). METHOD: Participants were 276 caregivers of serious juvenile offenders who were originally randomized to MST or individual therapy (IT)...
April 2017: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/28333085/ebasis-bioactive-substances-in-food-information-systems-and-bioactive-intakes-major-updates-of-the-bioactive-compound-composition-and-beneficial-bioeffects-database-and-the-development-of-a-probabilistic-model-to-assess-intakes-in-europe
#15
Jenny Plumb, Sandrine Pigat, Foteini Bompola, Maeve Cushen, Hannah Pinchen, Eric Nørby, Siân Astley, Jacqueline Lyons, Mairead Kiely, Paul Finglas
eBASIS (Bioactive Substances in Food Information Systems), a web-based database that contains compositional and biological effects data for bioactive compounds of plant origin, has been updated with new data on fruits and vegetables, wheat and, due to some evidence of potential beneficial effects, extended to include meat bioactives. eBASIS remains one of only a handful of comprehensive and searchable databases, with up-to-date coherent and validated scientific information on the composition of food bioactives and their putative health benefits...
March 23, 2017: Nutrients
https://www.readbyqxmd.com/read/28332705/global-brain-asymmetry-is-increased-in-schizophrenia-and-related-to-avolition
#16
C Núñez, N Paipa, C Senior, M Coromina, S Siddi, S Ochoa, G Brébion, C Stephan-Otto
OBJECTIVE: Schizophrenia may be the result of a failure of the normal lateralization process of the brain. However, whole-brain asymmetry has not been assessed up to date. Here, we propose a novel measure of global brain asymmetry based on the Dice coefficient to quantify similarity between brain hemispheres. METHOD: Global gray and white matter asymmetry was calculated from high-resolution T1 structural images acquired from 24 patients with schizophrenia and 26 healthy controls, age- and sex-matched...
March 23, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28332275/thyroid-dysfunction-in-patients-with-down-syndrome-results-from-a-multi-institutional-registry-study
#17
Jenifer Lavigne, Christianne Sharr, Ibrahim Elsharkawi, Al Ozonoff, Nicole Baumer, Campbell Brasington, Sheila Cannon, Blythe Crissman, Emily Davidson, Jose C Florez, Priya Kishnani, Angela Lombardo, Jordan Lyerly, Mary Ellen McDonough, Alison Schwartz, Kathryn Berrier, Susan Sparks, Kara Stock-Guild, Tomi L Toler, Kishore Vellody, Lauren Voelz, Brian G Skotko
The goals of this undertaking were to assess the outcomes of thyroid screening tests and adherence to thyroid screening guidelines across five Down syndrome (DS) specialty clinics in various states. Data related to thyroid screening were collected for 663 individuals across five clinics specializing in the comprehensive care of individuals with DS for a period of 1 year. Of the 663 participants, 47.7% of participants had a TSH and free T4 ordered at their DS specialty clinic visit. Approximately 19.0% (60/316) had a new thyroid disorder diagnosis made...
March 23, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28331987/hypertension-up-to-date-sprint-to-spyral
#18
REVIEW
Saarraaken Kulenthiran, Sebastian Ewen, Michael Böhm, Felix Mahfoud
Hypertension is the most common chronic cardiovascular condition with increasing prevalence all over the world. Treatment of patients at risk requires a multimodal therapeutic concept to adjust blood pressure, including systematic identification of secondary causes of hypertension or pseudo-resistance, lifestyle modification, polypharmacy, and as well as accompanying risk factors and comorbidities. The present review discusses recent studies on patients with increased cardiovascular risk potentially influencing future treatment strategies...
March 22, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28331115/spontaneous-multicentric-soft-tissue-sarcoma-in-a-captive-african-pygmy-hedgehog-atelerix-albiventris-case-report-and-literature-review
#19
Josué Díaz-Delgado, Roy Pool, Sharman Hoppes, Argine Cerezo, Óscar Quesada-Canales, George Stoica
This report describes the clinical, macroscopic, histopathological and immunohistological features of a spontaneous multicentric extraskeletal sarcoma in an adult male African hedgehog (Atelerix albiventris). It also provides a succinct up-to-date review on neoplasia in this species. On autopsy examination, main gross findings included a moderately demarcated cranial mass and a multilobulated, caudal intra-abdominal mass. The cranial mass had perforated the underlying temporal and occipital bones and had extended into the cranial vault and was compressing the surface of the cerebellum and cerebrum...
March 23, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28329646/gaps-in-the-understanding-and-treatment-of-skin-cancer-in-people-of-color
#20
Ajay Kailas
People of color are at significantly higher risk in mortality from skin cancers, such as melanoma, than Caucasians. Around 4,500,000 people of color are affected by skin cancer The five-year survival rates from melanoma are 81.1% for Hispanics, 80.2% for Asians, 72.2% for African- Americans, and 89.6% for Caucasians. For this reason, it is important to ensure the scientific literature reflects the most up to date recommendations and treatment for blacks regarding skin cancer. Therefore the authors conducted a "gap analysis" on the current treatment of skin cancer in people of color...
September 15, 2016: Dermatology Online Journal
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