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https://www.readbyqxmd.com/read/29222899/prevalence-and-determinants-of-iron-deficiency-anemia-among-non-pregnant-women-of-reproductive-age-in-pakistan
#1
Muhammad Atif Habib, Camille Raynes-Greenow, Sajid Bashir Soofi, Noshad Ali, Sidrah Nausheen, Imran Ahmed, Zulfiqar Ahmed Bhutta, Kirsten I Black
BACKGROUND AND OBJECTIVES: Iron deficiency Anemia (IDA) in women of reproductive age is a recognized public health concern that impairs health and well-being in women and is associated with adverse reproductive outcomes. In Pakistan there is a dearth of up-to-date information on the prevalence and predictors of IDA. This study sought to investigate IDA in Pakistani women. METHODS AND STUDY DESIGN: Secondary analysis was performed using the National Nutrition Survey in Pakistan 2011- 2012...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29222832/written-action-plans-for-children-with-long-term-conditions-a-systematic-review-and-synthesis-of-qualitative-data
#2
REVIEW
Andrea Waldecker, Alice Malpass, Anna King, Matthew J Ridd
BACKGROUND: Long-term conditions (LTCs) in children require a high level of self-management. Written action plans (WAPs) have been advocated to guide decision-making and support self-management but there is uncertainty about how WAPs "work" and what aspects are important for successful implementation. OBJECTIVE: To review and synthesize existing qualitative evidence about the design and use of WAPs across childhood LTCs. METHOD: We undertook a systematic search of the literature (Medline, EMBASE, CiNAHL, PsycInfo, Web of science) from inception to May 2015; critically appraised included studies; and synthesized the findings, drawing on normalisation process theory...
December 9, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/29222757/rna-sequencing-and-analysis-in-microorganisms-for-metabolic-network-reconstruction
#3
Eva Pinatel, Clelia Peano
There is a strict interplay between metabolic networks and transcriptional regulation in bacteria; indeed, the transcriptome regulation, affecting the expression of large gene sets, can be used to predict the likely "on" or "off" state of metabolic genes as a function of environmental factors. Up to date, many bacterial transcriptomes have been studied by RNAseq, hundreds of experiments have been performed, and Giga bases of sequences have been produced. All this transcriptional information could potentially be integrated into metabolic networks in order to obtain a more comprehensive view of their regulation and to increase their prediction power...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29222304/targeting-novel-mechanisms-of-pain-in-sickle-cell-disease
#4
REVIEW
Huy Tran, Mihir Gupta, Kalpna Gupta
Patients with sickle cell disease (SCD) suffer from intense pain that can start during infancy and increase in severity throughout life, leading to hospitalization and poor quality of life. A unique feature of SCD is vaso-occlusive crises (VOCs) characterized by episodic, recurrent, and unpredictable episodes of acute pain. Microvascular obstruction during a VOC leads to impaired oxygen supply to the periphery and ischemia reperfusion injury, inflammation, oxidative stress, and endothelial dysfunction, all of which may perpetuate a noxious microenvironment leading to pain...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29222056/are-bisphosphonates-efficacious-in-knee-osteoarthritis-a-meta-analysis-of-randomized-controlled-trials
#5
Elizaveta E Vaysbrot, Mikala C Osani, Mia-Cara Musetti, Timothy E McAlindon, Raveendhara R Bannuru
OBJECTIVE: To clarify the effects of bisphosphonates in knee osteoarthritis (OA) using an up-to-date meta-analysis of randomized controlled trials (RCTs). DESIGN: The protocol is registered in PROSPERO (CRD42017073449). We searched MEDLINE, EMBASE, Google Scholar, Web of Science, and Cochrane Database from inception until August 2017. We included only RCTs comparing any bisphosphonates vs. placebo in knee OA patients and reporting validated pain and function scales, radiographic progression, and adverse events outcomes...
December 5, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29219862/when-can-we-predict-the-outcome-of-an-electroconvulsive-therapy-course-in-adolescents-a-retrospective-study
#6
Hagai Maoz, Uri Nitzan, Yiftach Goldwyn, Israel Krieger, Yuval Bloch
OBJECTIVE: There is a dearth of up-to-date literature regarding electroconvulsive therapy (ECT) in adolescents, and the question of when to pronounce course failure has not been properly addressed. The current study aims to evaluate trajectories of clinical status throughout ECT courses in adolescent patients. METHODS: We retrieved detailed data of 36 patients who received ECT in our treatment center. Clinical records were retrospectively assessed and evaluated every 6 ECT sessions to quantify Clinical Global Impressions-Improvement (CGI-I) scores...
December 6, 2017: Journal of ECT
https://www.readbyqxmd.com/read/29219005/contemporary-nationwide-cardiology-registers-up-to-date-registry-data-are-required
#7
Jari A Laukkanen
No abstract text is available yet for this article.
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29218481/concepts-for-a-therapeutic-prolongation-of-nephrogenesis-in-preterm-and-low-birth-weight-babies-must-correspond-to-structural-functional-properties-in-the-nephrogenic-zone
#8
REVIEW
Will W Minuth
Numerous investigations are dealing with anlage of the mammalian kidney and primary development of nephrons. However, only few information is available about the last steps in kidney development leading at birth to a downregulation of morphogen activity in the nephrogenic zone and to a loss of stem cell niches aligned beyond the organ capsule. Surprisingly, these natural changes in the developmental program display similarities to processes occurring in the kidneys of preterm and low-birth-weight babies. Although those babies are born at a time with a principally intact nephrogenic zone and active niches, a high proportion of them suffers on impairment of nephrogenesis resulting in oligonephropathy, formation of atypical glomeruli, and immaturity of parenchyma...
December 7, 2017: Molecular and Cellular Pediatrics
https://www.readbyqxmd.com/read/29218397/can-we-better-predict-the-biologic-behavior-of-incidental-ipmn-a-comprehensive-analysis-of-molecular-diagnostics-and-biomarkers-in-intraductal-papillary-mucinous-neoplasms-of-the-pancreas
#9
Kiara A Tulla, Ajay V Maker
PURPOSE: Predicting the biologic behavior of intraductal papillary mucinous neoplasm (IPMN) remains challenging. Current guidelines utilize patient symptoms and imaging characteristics to determine appropriate surgical candidates. However, the majority of resected cysts remain low-risk lesions, many of which may be feasible to have under surveillance. We herein characterize the most promising and up-to-date molecular diagnostics in order to identify optimal components of a molecular signature to distinguish levels of IPMN dysplasia...
December 7, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/29216732/vitamin-b12-sources-and-microbial-interaction
#10
Fumio Watanabe, Tomohiro Bito
Vitamin B12 is synthesized only by certain bacteria and archaeon, but not by plants. The synthesized vitamin B12 is transferred and accumulates in animal tissues, which can occur in certain plant and mushroom species through microbial interaction. In particular, the meat and milk of herbivorous ruminant animals (e.g. cattle and sheep) are good sources of vitamin B12 for humans. Ruminants acquire vitamin B12, which is considered an essential nutrient, through a symbiotic relationship with the bacteria present in their stomachs...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29215775/an-assessment-of-the-microbiological-quality-and-safety-of-raw-drinking-milk-on-retail-sale-in-england
#11
Caroline Willis, Frieda Jørgensen, Heather Aird, Nicola Elviss, Andrew Fox, Claire Jenkins, Deborah Fenelon, Lorraine Sadler-Reeves, Jim McLauchlin
AIMS: This study aimed to review the microbiological results for raw drinking milk (RDM) samples submitted to Public Health England laboratories between 2014 and 2016 in order to produce up-to-date data on the microbiological safety of RDM and inform future risk assessments on its sale. METHODS AND RESULTS: A total of 902 samples of RDM were collected from retail sale in England for microbiological examination. Overall, 454/770 samples (59.0%) taken for routine monitoring were of a satisfactory quality, whilst eight (1...
December 7, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29215155/prophylactic-antibiotics-before-cord-clamping-in-cesarean-delivery-a-systematic-review
#12
Claudia Bollig, Monika Nothacker, Cornelius Lehane, Edith Motschall, Britta Lang, Joerg J Meerpohl, Christine M Schmucker
The number of clinical trials investigating the optimal timing of prophylactic antibiotics in cesarean section increased rapidly over the last few years. We conducted a systematic review to inform up-to date evidence-based guidelines to prevent postpartum infectious morbidity in the mother and rule out any safety issues related to antepartum antibiotic exposure in infants MATERIAL AND METHODS: Four bibliographic databases were searched for published reports of trials. Ongoing or unpublished studies were searched in Clinicaltrials...
December 7, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29212881/risk-of-rotavirus-nosocomial-spread-after-inpatient-pentavalent-rotavirus-vaccination
#13
Annika M Hofstetter, Kirsten Lacombe, Eileen J Klein, Charla Jones, Bonnie Strelitz, Elizabeth Jacobson, Daksha Ranade, M Leanne Ward, Slavica Mijatovic-Rustempasic, Diana Evans, Mary Wikswo, Michael D Bowen, Umesh D Parashar, Daniel C Payne, Janet A Englund
BACKGROUND: Infants born prematurely or with underlying conditions are at increased risk of severe rotavirus disease and associated complications. Given the theoretical risk of nosocomial transmission of vaccine-type rotavirus, rotavirus vaccination is recommended for infants at or after discharge from neonatal care settings. Because the first dose should be administered by 104 days of age, some infants may be age-ineligible for vaccination if delayed until discharge. METHODS: This prospective cohort included infants admitted to an urban academic medical center between birth and 104 days who received care in intensive care settings...
December 6, 2017: Pediatrics
https://www.readbyqxmd.com/read/29212530/identifying-genotype-phenotype-relationships-in-biomedical-text
#14
Maryam Khordad, Robert E Mercer
BACKGROUND: One important type of information contained in biomedical research literature is the newly discovered relationships between phenotypes and genotypes. Because of the large quantity of literature, a reliable automatic system to identify this information for future curation is essential. Such a system provides important and up to date data for database construction and updating, and even text summarization. In this paper we present a machine learning method to identify these genotype-phenotype relationships...
December 6, 2017: Journal of Biomedical Semantics
https://www.readbyqxmd.com/read/29212338/-incidence-of-diabetes-from-the-perspective-of-social-security-benefits
#15
Libuše Čeledová, Rostislav Čevela
The article analyzes the development of the activity of Medical Assessment Service for people with diabetes mellitus for selected assessment categories in the assessment of health conditions from 2012 to 2016. The assessment criteria for assessing disability, the degree of dependency for care allowance and the health status for grant for special aid, and certificate of person with disability are set out in the legislation. The incidence of disability for diabetes declined by 13 % between 2012 and 2016 and by 10 % for the degree of dependency for care allowance...
2017: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/29209788/-reform-of-emergency-physician-training-in-austria-finally-up-to-date
#16
REVIEW
H Trimmel, M Baubin, J Kreutziger, G Frank, G Prause
During the last 20 years Austrian prehospital emergency medical services (EMS) have significantly improved. The structure and organization of Austrian EMS comply with European standards but training requirements for prehospital EMS physicians are insufficient when compared with other countries. Although some EMS systems follow the German or Swiss postgraduate training concepts, the legal requirements in Austria defining the scope of mandatory training for physicians in the prehospital setting are only minimal...
December 5, 2017: Der Anaesthesist
https://www.readbyqxmd.com/read/29209597/meckel-gruber-syndrome-an-update-on-diagnosis-clinical-management-and-research-advances
#17
REVIEW
Verity Hartill, Katarzyna Szymanska, Saghira Malik Sharif, Gabrielle Wheway, Colin A Johnson
Meckel-Gruber syndrome (MKS) is a lethal autosomal recessive congenital anomaly syndrome caused by mutations in genes encoding proteins that are structural or functional components of the primary cilium. Conditions that are caused by mutations in ciliary genes are collectively termed the ciliopathies, and MKS represents the most severe condition in this group of disorders. The primary cilium is a microtubule-based organelle, projecting from the apical surface of vertebrate cells. It acts as an "antenna" that receives and transduces chemosensory and mechanosensory signals, but also regulates diverse signaling pathways, such as Wnt and Shh, that have important roles during embryonic development...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29208415/guideline-on-terminology-and-definitions-of-updating-clinical-guidelines-the-updating-glossary
#18
L Martínez García, H Pardo-Hernández, A J Sanabria, P Alonso-Coello, K Penman, E McFarlane
OBJECTIVE: The Guidelines International Network (G-I-N) Updating Guidelines Working Group launched an initiative to develop a glossary (the Updating Glossary) with domains, terms, definitions, and synonyms related to updating of clinical guidelines (CGs). STUDY DESIGN AND SETTING: The Steering Committee developed an initial list of domains, terms, definitions, and synonyms through brainstorming and discussion. The Panel Members participated in three rounds of feedback to discuss, refine, and clarify the proposed terms, definitions, and synonyms...
December 2, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29205314/survival-among-children-diagnosed-with-acute-lymphoblastic-leukemia-in-the-united-states-by-race-and-age-2001-to-2009-findings-from-the-concord-2-study
#19
Eric W Tai, Kevin C Ward, Audrey Bonaventure, David A Siegel, Michel P Coleman
BACKGROUND: Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. This report describes the survival of children with ALL in the United States using the most comprehensive and up-to-date cancer registry data. METHODS: Data from 37 state cancer registries that cover approximately 80% of the US population were used. Age-standardized survival up to 5 years was estimated for children aged 0-14 years who were diagnosed with ALL during 2 periods (2001-2003 and 2004-2009)...
December 15, 2017: Cancer
https://www.readbyqxmd.com/read/29204334/norovirus-disease-in-older-adults-living-in-long-term-care-facilities-strategies-for-management
#20
Yingxi Chen, Aron J Hall, Martyn D Kirk
Purpose of Review: Noroviruses are the most common cause of gastroenteritis outbreaks in long-term care facility (LTCFs). This review summarizes the most up-to-date knowledge on norovirus infection in LTCFs with the aim of identifying potential strategies for management. Recent Findings: LTCF residents are at greater risk of norovirus infection. Early identification of norovirus infection and prompt initiation of appropriate supportive therapy are required to reduce morbidity and mortality...
2017: Current Geriatrics Reports
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