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https://www.readbyqxmd.com/read/29653275/safety-and-efficacy-of-flow-diverter-treatment-for-aneurysm-in-small-cerebral-vessels-a-systematic-review-and-meta-analysis
#1
REVIEW
Yazhou Yan, Deyuan Zhu, Haishuang Tang, Qinghai Huang
PURPOSE: To clarify the safety and efficacy of flow diverter (FD) treatment for aneurysm in small cerebral vessels, we conducted a systematic review of the literature analyzing perioperative and long-term clinical and angiographic outcomes. METHODS: A comprehensive review of the up-to-date literature for studies with ≥10 patients related to FD treatment of small vessel aneurysms published was performed. Random-effects meta-analysis was used to pool the following outcomes: complete occlusion, technical procedural success, perioperative mortality, perioperative stroke, procedure-related morbidity and mortality, all complications, long-term mortality, and overall good outcome...
April 10, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29651363/surgical-management-of-the-drooling-child
#2
REVIEW
Rachael Lawrence, Neil Bateman
Purpose of Review: Our goal is to present the most up-to-date options in the surgical management of drooling in the paediatric population. While the clinical assessment of the drooling child and conservative management options are discussed, this review focuses on the most recent evidence for surgical interventions to treat drooling in children. Recent Findings: In terms of advances in the management of drooling, further experience and outcomes with the use of botulinum toxin injections is discussed...
2018: Current Otorhinolaryngology Reports
https://www.readbyqxmd.com/read/29650407/chronic-obstructive-pulmonary-disease-in-china-a-nationwide-prevalence-study
#3
Liwen Fang, Pei Gao, Heling Bao, Xun Tang, Baohua Wang, Yajing Feng, Shu Cong, Juan Juan, Jing Fan, Ke Lu, Ning Wang, Yonghua Hu, Linhong Wang
BACKGROUND: Because of the rapid change in economic development and lifestyle in China, and the ageing population, concerns have grown that chronic obstructive pulmonary disease (COPD) could become epidemic. An up-to-date nationwide estimation of COPD prevalence in China is needed. METHODS: We did a cross-sectional survey of a nationally representative sample of individuals from mainland China aged 40 years or older. The primary outcome was COPD, defined according to the 2017 Global Initiative for Chronic Obstructive Lung Disease (GOLD) lung function criteria...
April 9, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29649983/ncx-db-a-unified-resource-for-integrative-analysis-of-the-sodium-calcium-exchanger-super-family
#4
Katrin Bode, Damien M O'Halloran
Na+ /Ca2+ exchangers are low-affinity high-capacity transporters that mediate Ca2+ extrusion by coupling Ca2+ efflux to the influx of Na+ ions. The Na+ /Ca2+ exchangers form a super-family comprised of three branches each differing in ion-substrate selectivity: Na+ /Ca2+ exchangers (NCX), Na+ /Ca2+ /K+ exchangers, and Ca2+ /cation exchangers. Their primary function is to maintain Ca2+ homeostasis and play a particularly important role in excitable cells that experience transient Ca2+ fluxes. Research into the role and activity of Na+ /Ca2+ exchangers has focused extensively on the cardio-vascular system, however, growing evidence suggests that Na+ /Ca2+ exchangers play a key role in neuronal processes such as memory formation, learning, oligodendrocyte differentiation, neuroprotection during brain ischemia and axon guidance...
April 13, 2018: BMC Neuroscience
https://www.readbyqxmd.com/read/29649981/in-silico-cancer-research-towards-3r
#5
Claire Jean-Quartier, Fleur Jeanquartier, Igor Jurisica, Andreas Holzinger
BACKGROUND: Improving our understanding of cancer and other complex diseases requires integrating diverse data sets and algorithms. Intertwining in vivo and in vitro data and in silico models are paramount to overcome intrinsic difficulties given by data complexity. Importantly, this approach also helps to uncover underlying molecular mechanisms. Over the years, research has introduced multiple biochemical and computational methods to study the disease, many of which require animal experiments...
April 12, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29649979/ginseng-genome-database-an-open-access-platform-for-genomics-of-panax-ginseng
#6
Murukarthick Jayakodi, Beom-Soon Choi, Sang-Choon Lee, Nam-Hoon Kim, Jee Young Park, Woojong Jang, Meiyappan Lakshmanan, Shobhana V G Mohan, Dong-Yup Lee, Tae-Jin Yang
BACKGROUND: The ginseng (Panax ginseng C.A. Meyer) is a perennial herbaceous plant that has been used in traditional oriental medicine for thousands of years. Ginsenosides, which have significant pharmacological effects on human health, are the foremost bioactive constituents in this plant. Having realized the importance of this plant to humans, an integrated omics resource becomes indispensable to facilitate genomic research, molecular breeding and pharmacological study of this herb...
April 12, 2018: BMC Plant Biology
https://www.readbyqxmd.com/read/29649851/primary-malignant-melanoma-in-the-pineal-region-case-report-and-literature-review
#7
Christopher Wendel, Denis Laurent Kaech, Martin Woodtli
BACKGROUND:  Primary pineal malignant melanoma is a rare type of primary central nervous system melanoma with only 19 cases reported in the literature. CASE REPORT:  We present a case of a 53-year-old man with primary melanoma of the pineal region. He presented to the emergency department with gait unsteadiness and ataxia. Magnetic resonance imaging (MRI) revealed a 22 × 17 × 22-mm mass in the pineal region. On MRI the tumor was hyperintense in T1, isointense in T2, and on T1-weighted images with gadolinium enhancement it appeared homogeneously hyperintense with hypointense spots...
April 12, 2018: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/29649771/systematic-forensic-toxicological-analysis-by-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry-in-serum-and-comparison-to-gas-chromatography-mass-spectrometry
#8
Marcel Grapp, Christoph Kaufmann, Frank Streit, Lutz Binder
Comprehensive screening procedures for psychoactive agents in body fluids are an essential task in clinical and forensic toxicology. With the continuous emergence and adaption of new psychoactive substances (NPS) keeping a screening method up to date is challenging. To meet these demands, hyphenated high-resolution mass spectrometry has gained interest as extensive and expandable screening approach. Here we present a comprehensive method for systematic toxicological analysis of serum by liquid chromatography-quadrupole-time-of-flight mass spectrometry (LC-QTOF-MS) with data independent acquisition...
April 3, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29648777/applications-of-light-responsive-systems-for-cancer-theranostics
#9
Hongzhong Chen, Yanli Zhao
Achieving controlled and targeted delivery of chemotherapeutic drugs and other therapeutic agents to tumor sites is challenging. Among many stimulus strategies, light as a mode of action shows various advantages such as high spatiotemporal selectivity, minimal invasiveness and easy operation. Thus, drug delivery systems (DDSs) have been designed with the incorporation of various functionalities responsive to light as an exogenous stimulus. Early development has focused on guiding chemotherapeutic drugs to designated location, followed by the utilization of UV irradiation for controlled drug release...
April 12, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29645380/s1-guidelines-dermatoses-associated-with-dermal-lymphostasis
#10
Joachim Dissemond, Finja Jockenhöfer, Anya Miller, Günter Kurzhals, Shahrouz Noori, Stefanie Reich-Schupke, Martin Schlaeger, Erich Schubert, Markus Stücker, Tobias Weberschock, Hans Wilfried Jungkunz
The objective of the present S1 guidelines is to present current knowledge about dermatologically relevant diseases associated with localized dermal lymphostasis, thus facilitating their early detection, diagnostic workup, and targeted treatment. Whenever possible, treatment should be based on stage-appropriate and clearly defined algorithms. The numerous issues regarding differential diagnosis and treatment clinicians are confronted with in everyday clinical practice seem to warrant the publication of up-to-date guidelines...
April 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29645275/central-and-peripheral-chemoreceptors-in-sudden-infant-death-syndrome
#11
Andrea Porzionato, Veronica Macchi, Raffaele De Caro
The pathogenesis of Sudden Infant Death Syndrome (SIDS) has been ascribed to an underlying biological vulnerability to stressors during a critical period of development. This paper reviews the main data in the literature supporting the role of central (e.g. retrotrapezoid nucleus, serotoninergic raphe nuclei, locus coeruleus, orexinergic neurons, ventral medullary surface, solitary tract nucleus) and peripheral (e.g. carotid body) chemoreceptors in the pathogenesis of SIDS. Clinical and experimental studies indicate that central and peripheral chemoreceptors undergo critical development during the initial postnatal period, consistent with the age range of SIDS (< 1 year)...
April 12, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29645071/daclizumab-in-multiple-sclerosis
#12
REVIEW
F C Perez-Miralles
INTRODUCTION: Daclizumab is a monoclonal antibody directed against the CD25 subunit of the interleukin-2 receptor, investigated as a disease-modifying therapy in relapsing-remitting multiple sclerosis. The present review addresses how the drug was developed, the known mechanism of action of the drug and the up-to-date data of efficacy and safety. DEVELOPMENT: Daclizumab has shown superiority in prevention of relapses against placebo and low-dose interferon beta-1a at a level that puts it on par with the rest of current first-line drugs...
April 16, 2018: Revista de Neurologia
https://www.readbyqxmd.com/read/29644404/-amazingly-up-to-date-visions-of-geriatrics-1965
#13
EDITORIAL
Gerald F Kolb
No abstract text is available yet for this article.
April 11, 2018: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/29643977/role-and-possible-mechanisms-of-sirt1-in-depression
#14
REVIEW
Guofang Lu, Jianguo Li, Hongmei Zhang, Xin Zhao, Liang-Jun Yan, Xiaorong Yang
Depression is a common, devastating illness. Due to complicated causes and limited treatments, depression is still a major problem that plagues the world. Silent information regulator 1 (Sirt1) is a deacetylase at the consumption of NAD+ and is involved in gene silencing, cell cycle, fat and glucose metabolism, cellular oxidative stress, and senescence. Sirt1 has now become a critical therapeutic target for a number of diseases. Recently, a genetic study has received considerable attention for depression and found that Sirt1 is a potential gene target...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29643841/mouse-models-that-enhanced-our-understanding-of-adult-t-cell-leukemia
#15
REVIEW
Sara Moodad, Abdou Akkouche, Rita Hleihel, Nadine Darwiche, Marwan El-Sabban, Ali Bazarbachi, Hiba El Hajj
Adult T cell Leukemia (ATL) is an aggressive lymphoproliferative malignancy secondary to infection by the human T-cell leukemia virus type I (HTLV-I) and is associated with a dismal prognosis. ATL leukemogenesis remains enigmatic. In the era of precision medicine in oncology, mouse models offer one of the most efficient in vivo tools for the understanding of the disease biology and developing novel targeted therapies. This review provides an up-to-date and comprehensive account of mouse models developed in the context of ATL and HTLV-I infection...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29642690/impella-protected-pci-the-clinical-results-achieved-so-far
#16
Gabriele Pesarini, Andrea Gratta, Giulia Dolci, Mattia Lunardi, Flavio L Ribichini
The ability of interventional cardiologists to identify high-risk percutaneous coronary interventions (PCI) patients, requires the integration of different features belonging to medical history, organ damage, coronary anatomy and the nature of the acute event. The selection of a subgroup of patients that could benefit from mechanical support during interventions is a key feature to success. The introduction of the Impella percutaneous axial pump have added an easy to set-up, less-invasive and time consuming active-support device to the interventional toolbox...
April 11, 2018: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/29629811/transgender-patients-what-radiologists-need-to-know
#17
John S Sowinski, Richard B Gunderman
OBJECTIVE: The purposes of this article are to examine a few of the barriers the transgender population faces in achieving equitable health care, to suggest ways radiologists and radiology staff can help to address these obstacles and provide high-quality care to transgender patients, and to discuss a number of evidence-based guidelines regarding appropriate imaging and screening tests for the transgender population. CONCLUSION: Lesbian, gay, bisexual, and transgender individuals face numerous health care disparities, including stigmatization and discrimination in health care environments...
April 9, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29628678/unicompartmental-knee-replacement-current-perspectives
#18
REVIEW
Stefano Campi, Saket Tibrewal, Rory Cuthbert, Sheo B Tibrewal
Unicompartmental knee replacement (UKR) is an effective treatment for end-stage, symptomatic unicompartmental osteoarthritis of the knee. However, certain aspects of the procedure are still debated. These areas of discussion include patient selection criteria, implant design and the discrepancy in survival rates between national registries and independent case series. These may contribute in limiting the more widespread acceptance of unicompartmental knee replacement. The aim of this paper is to review the up-to-date evidence on UKR and discuss the most relevant controversies regarding this procedure...
January 2018: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29628602/anosmia-after-caudal-epidural-steroid-injection
#19
Ayhan Kaydu, Ebru Tarikçi Kiliç, Erhan Gökçek, Cem Kivilcim Kaçar
There are no reports for anosmia after caudal epidural steroid injections (CESIs). General anesthesia is among the reasons, but the reports up to date are extremely limited. There are no identifiable factors contributing to anosmia after epidural injection, so it is worth discussing. We present the case of a 50-year-old woman with no previous history of any sensory deficits. She experienced anosmia after CESI that had been performed due to her chronic low back pain and lasted for 4 months. Clinical and imaging studies did not reveal any pathology...
January 2018: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29628056/understanding-the-two-dose-hpv-vaccine-schedule
#20
Kate T McNair, Holly B Fontenot
Recent advances in human papillomavirus (HPV) science have led to updates to national HPV vaccine recommendations. This column takes a second look at two recent studies that provide evidence to support the current two-dose HPV vaccination schedule for youth ages 9 to 14 years. This short review will help nurses and other clinicians understand the health and economic benefits of the current dosing recommendation. Nurses are leaders in national vaccination efforts; therefore, it is vital that they remain up to date on the latest evidence that supports vaccination practice as well as health counseling and HPV vaccine recommendations...
April 2018: Nursing for Women's Health
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