Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
REVIEW
S K Brooks, D Weston, N Greenberg
OBJECTIVES: Infectious disease outbreaks can be distressing for everyone, especially those deemed to be particularly vulnerable such as pregnant women, who have been named a high-risk group in the current COVID-19 pandemic. This paper aimed to summarise existing literature on the psychological impact of infectious disease outbreaks on women who were pregnant at the time of the outbreak. STUDY DESIGN: The design of this study is a rapid review. METHODS: Five databases were searched for relevant literature, and main findings were extracted...
December 2020: Public Health
#2
REVIEW
Sony Priyanka Bandi, Shubhmita Bhatnagar, Venkata Vamsi Krishna Venuganti
Mucus is a viscoelastic gel that traps pathogens and other foreign particles to limit their penetration into the underlying epithelium. Dosage forms containing particle-based drug delivery systems are trapped in mucosal layers and will be removed by mucus turnover. Mucoadhesion avoids premature wash-off and prolongs the residence time of drugs on mucus. Moreover, mucus penetration is essential for molecules to access the underlying epithelial tissues. Various strategies have been investigated to achieve mucoadhesion and mucus penetration of drug carriers...
January 1, 2021: Acta Biomaterialia
#3
REVIEW
Vera Mahler, Jörg Kleine-Tebbe, Stefan Vieths
Allergen immunotherapy (AIT) is the only causally effective, disease-modifying form of therapy that, in addition to alleviating allergic symptoms, counteracts disease progression.This article provides an up-to-date overview of immunological, regulatory and practical aspects of AIT. Current literature was included and recent conceptual regulatory developments from the Division of Allergology at the higher federal authority (Paul-Ehrlich-Institut) are presented.The 62 AIT products currently approved in Germany and further 61 AIT products under the development program of the Therapy Allergen Ordinance (TAO) include 95 products for subcutaneous (SCIT) and 28 for sublingual (SLIT) treatment of birch/alder/hazel pollen, grass pollen, weed pollen, house dust mite and insect venom allergies...
November 2020: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
#4
JOURNAL ARTICLE
Gayatri Raj Ghosh, Aaron L A Nelson
Seizures present in childhood with infinite diversity. History alone may suffice for diagnosis in some cases; more often additional evidence is needed to clarify events of concern. Electroencephalography (EEG) is a primary methodology used for seizure identification and management. Pediatric and adolescent health care providers are increasingly asked to make decisions about when and how to refer patients for eventual monitoring and must then be able to confidently interpret any resulting report(s). Comprehensive literature review was undertaken to provide a succinct and up-to-date overview aimed at general and subspecialty non-neurologist pediatric and adolescent health care providers to not only convey a solid general understanding of EEG and what it entails for patients and their families, but also foster a deeper understanding of the indications for monitoring-and how to interpret documented findings...
October 30, 2020: Current Problems in Pediatric and Adolescent Health Care
#5
JOURNAL ARTICLE
Si Yang, Shuai Lin, Na Li, Yujiao Deng, Meng Wang, Dong Xiang, Grace Xiang, Shuqian Wang, Xianghua Ye, Yi Zheng, Jia Yao, Zhen Zhai, Ying Wu, Jingjing Hu, Huafeng Kang, Zhijun Dai
BACKGROUND: The epidemiology of esophageal cancer (EC) can elucidate its causes and risk factors and help develop prevention strategies. We aimed to provide an overview of the burden, trends, and risk factors of EC in China from 1990 to 2017. We also investigated the differences between China, Japan, and South Korea and discussed the possible causes of the disparities. METHODS: We used the Global Burden of Disease Study 2017 to obtain data on incident cases, deaths, disability-adjusted life-year (DALY) cases, age-standardized incidence rate (ASIR), age-standardized death rate (ASDR), and age-standardized DALY rate of EC in China, Japan, and South Korea from 1990 to 2017...
November 2, 2020: Journal of Hematology & Oncology
#6
REVIEW
Brigitta Kis, Stefana Avram, Ioana Zinuca Pavel, Adelina Lombrea, Valentina Buda, Cristina Adriana Dehelean, Codruta Soica, Mukerrem Betul Yerer, Florina Bojin, Roxana Folescu, Corina Danciu
Populus nigra L. (Salicaceae family) is one of the most popular trees that can be found in deciduous forests. Some particularities that characterize the Populus genus refer to the fact that it includes more than 40 species, being widespread especially in Europe and Asia. Many residues, parts of this tree can be used as a bioresource for different extracts as active ingredients in pharmaceuticals next to multiple benefits in many areas of medicine. The present review discusses the latest findings regarding the phytochemical composition and the therapeutic properties of Populus nigra L...
October 29, 2020: Plants (Basel, Switzerland)
#7
REVIEW
Sophie L Maiocchi, Jacqueline Ku, Thuan Thai, Enoch Chan, Martin D Rees, Shane R Thomas
Myeloperoxidase (MPO) is a prominent mammalian heme peroxidase and a fundamental component of the innate immune response against microbial pathogens. In recent times, MPO has received considerable attention as a key oxidative enzyme capable of impairing the bioactivity of nitric oxide (NO) and promoting endothelial dysfunction; a clinically relevant event that manifests throughout the development of inflammatory cardiovascular disease. Increasing evidence indicates that during cardiovascular disease, MPO is released intravascularly by activated leukocytes resulting in its transport and sequestration within the vascular endothelium...
October 30, 2020: Pharmacology & Therapeutics
#8
JOURNAL ARTICLE
Ahyoung Choi, Insu Jang, Heewon Han, Min-Seo Kim, Jinhyuk Choi, Jieun Lee, Sung-Yup Cho, Yukyung Jun, Charles Lee, Jaesang Kim, Byungwook Lee, Sanghyuk Lee
High-throughput screening based on CRISPR-Cas9 libraries has become an attractive and powerful technique to identify target genes for functional studies. However, accessibility of public data is limited due to the lack of user-friendly utilities and up-to-date resources covering experiments from third parties. Here, we describe iCSDB, an integrated database of CRISPR screening experiments using human cell lines. We compiled two major sources of CRISPR-Cas9 screening: the DepMap portal and BioGRID ORCS. DepMap portal itself is an integrated database that includes three large-scale projects of CRISPR screening...
January 8, 2021: Nucleic Acids Research
#9
JOURNAL ARTICLE
Valery L Feigin, Theo Vos, Fares Alahdab, Arianna Maever L Amit, Till Winfried Bärnighausen, Ettore Beghi, Mahya Beheshti, Prachi P Chavan, Michael H Criqui, Rupak Desai, Samath Dhamminda Dharmaratne, E Ray Dorsey, Arielle Wilder Eagan, Islam Y Elgendy, Irina Filip, Simona Giampaoli, Giorgia Giussani, Nima Hafezi-Nejad, Michael K Hole, Takayoshi Ikeda, Catherine Owens Johnson, Rizwan Kalani, Khaled Khatab, Jagdish Khubchandani, Daniel Kim, Walter J Koroshetz, Vijay Krishnamoorthy, Rita V Krishnamurthi, Xuefeng Liu, Warren David Lo, Giancarlo Logroscino, George A Mensah, Ted R Miller, Salahuddin Mohammed, Ali H Mokdad, Maziar Moradi-Lakeh, Shane Douglas Morrison, Veeresh Kumar N Shivamurthy, Mohsen Naghavi, Emma Nichols, Bo Norrving, Christopher M Odell, Elisabetta Pupillo, Amir Radfar, Gregory A Roth, Azadeh Shafieesabet, Aziz Sheikh, Sara Sheikhbahaei, Jae Il Shin, Jasvinder A Singh, Timothy J Steiner, Lars Jacob Stovner, Mitchell Taylor Wallin, Jordan Weiss, Chenkai Wu, Joseph Raymond Zunt, Jaimie D Adelson, Christopher J L Murray
IMPORTANCE: Accurate and up-to-date estimates on incidence, prevalence, mortality, and disability-adjusted life-years (burden) of neurological disorders are the backbone of evidence-based health care planning and resource allocation for these disorders. It appears that no such estimates have been reported at the state level for the US. OBJECTIVE: To present burden estimates of major neurological disorders in the US states by age and sex from 1990 to 2017. DESIGN, SETTING, AND PARTICIPANTS: This is a systematic analysis of the Global Burden of Disease (GBD) 2017 study...
February 1, 2021: JAMA Neurology
#10
JOURNAL ARTICLE
Tung Hoang
BACKGROUND: Previous studies reported the positive viral RNA among coronavirus disease 2019 (COVID-19) recovered patients. This study aimed to summarize the current evidence of factors associated with the risk of disease recurrence. METHODS: PubMed and Embase were searched until September 2020 to identify studies assessing characteristics of recurrence and nonrecurrence subjects after discharge. Random-effects meta-analysis was used to pool estimates of odds ratio (OR) or weighted mean difference (WMD) and their 95% confidence intervals (CIs) across studies...
November 2, 2020: Journal of Medical Virology
#11
JOURNAL ARTICLE
Antonia Reyes, Nicolás Corrales, Nicolás M S Gálvez, Susan M Bueno, Alexis M Kalergis, Pablo A González
Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that plays critical roles during the cellular response to hypoxia. Under normoxic conditions, its function is tightly regulated by the degradation of its alpha subunit (HIF-1α), which impairs the formation of an active heterodimer in the nucleus that otherwise regulates the expression of numerous genes. Importantly, HIF-1 participates in both cancer and infectious diseases unveiling new therapeutic targets for those ailments. Here, we discuss aspects related to the activation of HIF-1, the effects of this transcription factor over immune system components, as well as the involvement of HIF-1 activity in response to viral infections in humans...
December 2020: Virulence
#12
JOURNAL ARTICLE
Asher Bashiri, Mila Giliutin, Hanna Ziedenberg, Ygal Plakht, Yael Baumfeld
PURPOSE: To develop a prognostic tool to predict the live birth rate in cases of repeated pregnancy losses. STUDY DESIGN: A retrospective cohort study including patients treated in the dedicated RPL clinic between 2000 and 2015. Background data was collected in the primary visit via questionnaires and medical records. The repeated pregnancy loss workup includes a genetic testing, endocrine testing, and anatomic abnormalities as well as thrombophilia.The prognostic tool took into account the unique contribution of the different risk factors, including maternal age, number of pregnancy losses, primary vs...
November 1, 2020: Journal of Maternal-fetal & Neonatal Medicine
#13
COMPARATIVE STUDY
Mohamad Moussa, Lazaros Lazarou, Athanasios Dellis, Mohamed Abou Chakra, Athanasios Papatsoris
Introduction : Currently, in prostate cancer, an increasing number of novel drugs are being used to delay its advancement to metastatic castration-resistant prostate cancer (mCRPC). Apalutamide, enzalutamide, and most recently, darolutamide (novel androgen receptor antagonists) have been approved for nonmetastatic castration-resistant prostate cancer (nmCRPC). Areas covered : The authors have evaluated darolutamide, covering all aspects of the clinical development, competence, and safety profile of the drug...
March 2021: Expert Opinion on Pharmacotherapy
#14
JOURNAL ARTICLE
Pranai K Buddhdev, Ivor S Vanhegan, Tahir Khan, Aresh Hashemi-Nejad
AIMS: Despite advances in the treatment of paediatric hip disease, adolescent and young adult patients can develop early onset end-stage osteoarthritis. The aims of this study were to address the indications and medium-term outcomes for total hip arthroplasty (THA) with ceramic bearings for teenage patients. METHODS: Surgery was performed by a single surgeon working in the paediatric orthopaedic unit of a tertiary referral hospital. Databases were interrogated from 2003 to 2017 for all teenage patients undergoing THA with a minimum 2...
November 2020: Bone & Joint Journal
#15
REVIEW
Joe Fenn, Natasha J Olby
Intervertebral disc disease (IVDD) has been recognized in dogs since the 1800s, when the first descriptions of extruded disc material within the vertebral canal were published. In the intervening time our understanding of intervertebral disc pathology in dogs and cats has increased dramatically, with many variations of IVDD described. Whilst the volume of literature and collective understanding of IVDD has expanded, there has also been scope for confusion as the definition of intervertebral disc disease, with its myriad different manifestations, becomes more complicated...
2020: Frontiers in Veterinary Science
#16
JOURNAL ARTICLE
Paul Bingham, Masako Wada, Mary van Andel, Andrew McFadden, Robert Sanson, Mark Stevenson
An incursion of an important exotic transboundary animal disease requires a prompt and intensive response. The routine analysis of up-to-date data, as near to real time as possible, is essential for the objective assessment of the patterns of disease spread or effectiveness of control measures and the formulation of alternative control strategies. In this paper, we describe the Standard Analysis of Disease Investigation (SADI), a toolbox for informing disease outbreak response, which was developed as part of New Zealand's biosecurity preparedness...
2020: Frontiers in Veterinary Science
#17
JOURNAL ARTICLE
José M Álvarez-Castro
Gene-environment interaction is a key part of evolutionary biology, animal, and plant breeding, and a number of health sciences, like epidemiology and precision medicine. However, bottlenecks in models of gene-environment interaction have recently been made manifest, particularly in the field of medicine and, consequently, specific improvements have been explicitly requested-namely, an implementation of gene-environment interaction satisfactorily disentangled from gene-environment correlation. The present paper meets those demands by providing mathematical developments that implement classical models of genetic effects and bring them up to date with the prospects current available data bestow...
2020: Frontiers in Genetics
#18
REVIEW
Yusuf Madaki Lekko, Peck Toung Ooi, Sharina Omar, Mazlina Mazlan, Siti Zubaidah Ramanoon, Sabri Jasni, Faez Firdaus Abdullah Jesse, Azlan Che-Amat
Tuberculosis (TB) is a chronic inflammatory and zoonotic disease caused by Mycobacterium tuberculosis complex (MTBC) members, which affects various domestic animals, wildlife, and humans. Some wild animals serve as reservoir hosts in the transmission and epidemiology of the disease. Therefore, the monitoring and surveillance of both wild and domestic hosts are critical for prevention and control strategies. For TB diagnosis, the single intradermal tuberculin test or the single comparative intradermal tuberculin test, and the gamma-interferon test, which is regarded as an ancillary test, are used...
September 2020: Veterinary World
#19
JOURNAL ARTICLE
Oluwatobi O Hunter, Audrey Wong, Jody Leng, Edward R Mariano
As healthcare practitioners continue to search for multimodal analgesic therapies to reduce postoperative opioid requirements, surgical ward nurses need to stay up to date on the status of emerging therapies. One of these is intravenous lidocaine for postoperative pain management. Unfortunately, there is a lack of resources to assist surgical ward nurses who are unfamiliar with lidocaine infusions for pain. This article aims to review the pharmacology of intravenous lidocaine for pain management, describe an experience of a university-affiliated Veterans Affairs hospital with implementation of intravenous lidocaine on the surgical ward, and suggest practical tools that can be used to develop protocols and educational content for nurses managing intravenous lidocaine infusions in the postoperative period...
October 29, 2020: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
#20
JOURNAL ARTICLE
A Sansone, A Aversa, G Corona, A D Fisher, A M Isidori, S La Vignera, E Limoncin, M Maggi, M Merico, E A Jannini
Premature ejaculation (PE) is the most prevalent male sexual dysfunction, and the most recently defined. PE is often mistakenly considered a purely psychosexological symptom by patients: the lacking awareness in regards to the pathophysiology and treatments often lead to resignation from the patients' side, making PE the most underdiagnosed sexual complaint. However, an ever-growing body of evidence supporting several organic factors has been developed in the last decades and several definitions have been suggested to encompass all defining features of PE...
May 2021: Journal of Endocrinological Investigation
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
