keyword
https://read.qxmd.com/read/32173393/chemopreventive-activity-of-tualang-honey-against-oral-squamous-cell-carcinoma-in-vivo
#21
JOURNAL ARTICLE
May Al-Koshab, Aied M Alabsi, Marina Mohd Bakri, Manimalar Selvi Naicker, Atefehalsadat Seyedan
OBJECTIVE: The aim of this study was to evaluate the chemopreventive activity of Malaysian jungle Tualang honey (TH) after oral carcinogenesis induced with 4-nitroquinoline 1-oxide (4 NQO). STUDY DESIGN: A total of 28 male Sprague-Dawley (SD) rats were distributed into 4 groups as follows: group 1 (nontreated group); group 2 (control), which received 4 NQO during 8 weeks in drinking water only; and groups 3 and 4, which received 4 NQO for 8 weeks in drinking water and treated with TH 1000 mg/kg and 2000 mg/kg by oral gavage for 10 weeks...
March 13, 2020: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://read.qxmd.com/read/31531177/malaysian-tualang-honey-inhibits-hydrogen-peroxide-induced-endothelial-hyperpermeability
#22
JOURNAL ARTICLE
Kogilavanee Devasvaran, Jun Jie Tan, Chin Theng Ng, Lai Yen Fong, Yoke Keong Yong
Malaysian Tualang honey (TH) is a known therapeutic honey extracted from the honeycombs of the Tualang tree (Koompassia excelsa) and has been reported for its antioxidant, anti-inflammatory, antiproliferative, and wound healing properties. However, the possible vascular protective effect of TH against oxidative stress remains unclear. In this study, the effects of TH on hydrogen peroxide- (H2 O2 -) elicited vascular hyperpermeability in human umbilical vein endothelial cells (HUVECs) and Balb/c mice were evaluated...
2019: Oxidative Medicine and Cellular Longevity
https://read.qxmd.com/read/31488962/tualang-honey-and-dha-rich-fish-oil-reduce-the-production-of-pro-inflammatory-cytokines-in-the-rat-brain-following-exposure-to-chronic-stress
#23
JOURNAL ARTICLE
Mohd A Asari, Mohd H Zulkaflee, K N S Sirajudeen, Nurul A Mohd Yusof, Nur S Mohd Sairazi
Objectives: The aim of the present study was to investigate the effects of Tualang honey (TH), DHA-rich fish oil, and their combination on the concentrations of selected pro-inflammatory cytokines in rat brains following exposure to chronic stress. Methods: Fifty male Sprague-Dawley rats were divided into (i) control, (ii) stress-exposed, (iii) stress-exposed and treated with TH (1 g/kg body weight twice daily via oral gavage), (iv) stress-exposed and treated with DHA-rich fish oil (450 mg/kg body weight twice daily via oral gavage), and (v) stress-exposed and treated with a combination of TH and DHA-rich fish oil...
August 2019: Journal of Taibah University Medical Sciences
https://read.qxmd.com/read/31453119/tualang-honey-ameliorates-viral-load-cd4-counts-and-improves-quality-of-life-in-asymptomatic-human-immunodeficiency-virus-infected-patients
#24
JOURNAL ARTICLE
Wan Nazirah Wan Yusuf, Wan Mohd Zahiruddin Wan Mohammad, Siew Hua Gan, Mahiran Mustafa, Che Badariah Abd Aziz, Siti Amrah Sulaiman
This is the first study to report on the effects of honey in asymptomatic HIV positive subjects in ameliorating CD4 count, viral load (VL) and quality of life (QOL). It is a randomized, controlled, open labelled study, comparing the effects of Tualang honey (TH) administration for six months at three different doses: 20 g (THL), 40 g (THI) or 60 g (THH) daily compared with control (no administered treatment, THC). Only asymptomatic HIV positive subjects (n=95) having CD4 count 250-600 cell/ml, not on antiretrovirals were enrolled...
October 2019: Journal of Traditional and Complementary Medicine
https://read.qxmd.com/read/31186997/clinical-and-antibacterial-effects-of-tualang-honey-on-pseudomonas-induced-keratitis-in-rabbit-eyes
#25
JOURNAL ARTICLE
Rajendran Punitan, Siti Amrah Sulaiman, Habsah B Hasan, Ismail Shatriah
Introduction Pseudomonas aeruginosa is a common cause of microbial keratitis that can cause a significant loss of visual acuity. Antibiotics, including fluoroquinolones and aminoglycosides, are clinically effective against Pseudomonas-induced keratitis, but their effectiveness has been conspicuously reduced as resistant pathogens have become more potent. This study sought to evaluate the clinical and antibacterial effects of tualang honey as an alternative therapeutic agent against Pseudomonas-induced keratitis...
March 27, 2019: Curēus
https://read.qxmd.com/read/30591885/tualang-honey-adjunct-with-anastrozole-improve-parenchyma-enhancement-of-breast-tissue-in-breast-cancer-patients-a-randomized-controlled-trial
#26
JOURNAL ARTICLE
Nik Shah Hizan, Nor Hasnina Mohd Hassan, Juhara Haron, Murtala Bello Abubakar, Nik Munirah Nik Mahdi, Siew Hua Gan
Background: To investigate whether the combination of anastrozole and Tualang honey (T honey) influences background parenchymal enhancement (BPE) in breast magnetic resonance imaging (MRI) of postmenopausal women with breast cancer. Methods: A total of 30 patients were recruited and randomly divided into control (anastrozole 1 mg daily) and intervention (anastrozole 1 mg + T honey 20 g daily). The BPE of the contralateral breast before and six months following treatment was compared using the sign test...
December 2018: Integrative Medicine Research
https://read.qxmd.com/read/30591413/effects-of-tualang-honey-in-modulating-nociceptive-responses-at-the-spinal-cord-in-offspring-of-prenatally-stressed-rats
#27
JOURNAL ARTICLE
Che Badariah Abd Aziz, Siti Qusyasyiah Ahmad Suhaimi, Hidani Hasim, Asma Hayati Ahmad, Idris Long, Rahimah Zakaria
OBJECTIVE: This study was done to determine whether Tualang honey could prevent the altered nociceptive behaviour, with its associated changes of oxidative stress markers and morphology of the spinal cord, among the offspring of prenatally stressed rats. METHODS: Pregnant rats were divided into three groups: control, stress, and stress treated with Tualang honey. The stress and stress treated with Tualang honey groups were subjected to restraint stress from day 11 of pregnancy until delivery...
December 15, 2018: Journal of Integrative Medicine
https://read.qxmd.com/read/30477832/long-term-effects-of-honey-on-cardiovascular-parameters-and-anthropometric-measurements-of-postmenopausal-women
#28
JOURNAL ARTICLE
Siti Zubaidah Ab Wahab, Nik Hazlina Nik Hussain, Rahimah Zakaria, Azidah Abdul Kadir, Norazlina Mohamed, Noorlaili Mohd Tohit, Mohd Noor Norhayati, Intan Idiana Hassan
OBJECTIVE: To investigate the long-term effects of Tualang Honey versus Honey Cocktail (mixture of honey, bee bread, and royal jelly) on cardiovascular markers and anthropometric measurements of postmenopausal women. METHODS: We conducted a randomised, double blinded, two-armed parallel study comparing 20 g/day of Tualang Honey versus 20 g/day Honey Cocktail among postmenopausal women aged 45-65 years. The cardiovascular parameters and anthropometrics measurements were assessed at baseline, 6 months, and 12 months of the intervention...
December 2018: Complementary Therapies in Medicine
https://read.qxmd.com/read/30108663/tualang-honey-reduced-neuroinflammation-and-caspase-3-activity-in-rat-brain-after-kainic-acid-induced-status-epilepticus
#29
JOURNAL ARTICLE
Nur Shafika Mohd Sairazi, Kuttulebbai N S Sirajudeen, Mustapha Muzaimi, Swamy Mummedy, Mohd Asnizam Asari, Siti Amrah Sulaiman
The protective effect of tualang honey (TH) on neuroinflammation and caspase-3 activity in rat cerebral cortex, cerebellum, and brainstem after kainic acid- (KA-) induced status epilepticus was investigated. Male Sprague-Dawley rats were pretreated orally with TH (1.0 g/kg body weight) five times at 12 h intervals. KA (15 mg/kg body weight) was injected subcutaneously 30 min after last oral treatment. Rats were sacrificed at 2 h, 24 h, and 48 h after KA administration. Neuroinflammation markers and caspase-3 activity were analyzed in different brain regions 2 h, 24 h, and 48 h after KA administration...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://read.qxmd.com/read/30037274/a-simple-method-for-extracting-both-active-oily-and-water-soluble-extract-wse-from-nigella-sativa-l-seeds-using-a-single-solvent-system
#30
JOURNAL ARTICLE
Z M Babar, Wan Mohd Azizi, Solachuddin Ja Ichwan, Qamar Uddin Ahmed, Abul Kalam Azad, Imranul Mawa
The current study provides a way of extraction for both active NSO and WSE from Nigella sativa seeds using 98% methanol. About 1 kg of ground seeds was macerated by 1:2.5 w/v (g/mL) for 72 hours. After rotary evaporation and 7 days of continuous drying and chilling at 50 and 4 °C, NSO and WSE were obtained at the same instant. Solubility tests of 24 solvents and 11 thin layer chromatographic analyses while 2, 2-diphenyl-1-picrylhydrazyl free radical scavenging assay of NSO (73.66) , WSE (33.32) and NSO + WSE (78...
July 24, 2018: Natural Product Research
https://read.qxmd.com/read/28708420/dose-response-effect-of-tualang-honey-on-postprandial-antioxidant-activity-and-oxidative-stress-in-female-athletes-a-pilot-study
#31
RANDOMIZED CONTROLLED TRIAL
Nur Syamsina Ahmad, Azlina Abdul Aziz, Kin Weng Kong, Mohamad Shariff A Hamid, Jadeera Phaik Geok Cheong, Sareena Hanim Hamzah
OBJECTIVES: Tualang honey (TH) contains antioxidants such as ascorbic acid, phenolic acids, and flavonoids that may be protective against oxidative stress of exercise. The aim of this study was to examine the postprandial antioxidant activity and oxidative stress after ingestion of high and low dosages of TH in female athletes. MATERIALS AND METHODS: Twenty female athletes (aged 21.3 [2.1] years; body weight [BW] 54.1 [5.7] kg) were randomly assigned into two groups and consumed either 1...
December 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://read.qxmd.com/read/28479926/oral-administration-of-tualang-and-manuka-honeys-modulates-breast-cancer-progression-in-sprague-dawley-rats-model
#32
JOURNAL ARTICLE
Sarfraz Ahmed, Siti Amrah Sulaiman, Nor Hayati Othman
Breast cancer has been recognized as the leading cause of death in women worldwide. Research has shown the importance of complementary and alternative therapies in cancer. In this study, we investigated the antitumoural therapeutic effects of Malaysian Tualang honey (TH) and Australian/New Zealand Manuka honey (MH) against breast cancer in rats. Thirty syngeneic virgin female Sprague-Dawley (SD) rats were induced by the carcinogen 1-methyl-1-nitrosourea (MNU) 80 mg/kg. The treatment started when first palpable tumour reached 10-12 mm in size by dividing rats into following groups: Group 0 (negative control); Group 1 (positive control); and Groups 2 and 3 which received 1...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://read.qxmd.com/read/28399853/the-anti-cancer-effects-of-tualang-honey-in-modulating-breast-carcinogenesis-an-experimental-animal-study
#33
JOURNAL ARTICLE
Sarfraz Ahmed, Nor Hayati Othman
BACKGROUND: Honey has been shown to have anti-cancer effects, but the mechanism behind these effects is not fully understood. We investigated the role of Malaysian jungle Tualang honey (TH) in modulating the hematological parameters, estrogen, estrogen receptors (ER1) and pro and anti-apoptotic proteins expression in induced breast cancer in rats. METHODS: Fifty nulliparous female Sprague-Dawley rats were used and grouped as follows: Group 0 (healthy normal rats control), Group 1 (negative control; untreated rats), Groups 2, 3 and 4 received daily doses of 0...
April 11, 2017: BMC Complementary and Alternative Medicine
https://read.qxmd.com/read/28351393/effects-of-honey-supplementation-on-inflammatory-markers-among-chronic-smokers-a-randomized-controlled-trial
#34
RANDOMIZED CONTROLLED TRIAL
Wan Syaheedah Wan Ghazali, Aminah Che Romli, Mahaneem Mohamed
BACKGROUND: Honey has been demonstrated to possess anti-inflammatory property. This is a randomized, controlled, open-label trial to determine the effects of 12-week honey oral supplementation on plasma inflammatory markers such as high sensitive C-reactive protein, interleukin-6 and tumor necrosis factor-α among chronic smokers. METHODS/DESIGN: A total of 32 non-smokers and 64 chronic smokers from Quit Smoking Clinic and Health Campus, Universiti Sains Malaysia participated in the study...
March 28, 2017: BMC Complementary and Alternative Medicine
https://read.qxmd.com/read/28154488/antifungal-activity-of-lactic-acid-bacteria-strains-isolated-from-natural-honey-against-pathogenic-candida-species
#35
JOURNAL ARTICLE
Bulgasem Y Bulgasem, Mohd Nizam Lani, Zaiton Hassan, Wan Mohtar Wan Yusoff, Sumaya G Fnaish
The role of lactic acid bacteria (LAB) in honey as antifungal activity has received little attention and their mechanism of inhibitory of fungi is not fully understood. In this study, LAB were isolated from honey samples from Malaysia, Libya, Saudi Arabia, and Yemen. Twenty-five isolates were confirmed LAB by catalase test and Gram staining, and were screened for antifungal activity. Four LAB showed inhibitory activity against Candida spp. using the dual agar overlay method. And they were identified as Lactobacillus plantarum HS isolated from Al-Seder honey, Lactobacillus curvatus HH isolated from Al-Hanon honey, Pediococcus acidilactici HC isolated from Tualang honey and Pediococcus pentosaceus HM isolated from Al-Maray honey by the 16S rDNA sequence...
December 2016: Mycobiology
https://read.qxmd.com/read/28127418/tualang-honey-protects-the-rat-midbrain-and-lung-against-repeated-paraquat-exposure
#36
JOURNAL ARTICLE
Suk Peng Tang, Sirajudeen Kuttulebbai Nainamohamed Salam, Hasnan Jaafar, Siew Hua Gan, Mustapha Muzaimi, Siti Amrah Sulaiman
Paraquat (PQ) is a dopaminergic neurotoxin and a well-known pneumotoxicant that exerts its toxic effect via oxidative stress-mediated cellular injuries. This study investigated the protective effects of Tualang honey against PQ-induced toxicity in the midbrain and lungs of rats. The rats were orally treated with distilled water (2 mL/kg/day), Tualang honey (1.0 g/kg/day), or ubiquinol (0.2 g/kg/day) throughout the experimental period. Two weeks after the respective treatments, the rats were injected intraperitoneally with saline (1 mL/kg/week) or PQ (10 mg/kg/week) once per week for four consecutive weeks...
2017: Oxidative Medicine and Cellular Longevity
https://read.qxmd.com/read/28068984/effect-of-tualang-honey-against-ka-induced-oxidative-stress-and-neurodegeneration-in-the-cortex-of-rats
#37
JOURNAL ARTICLE
Nur Shafika Mohd Sairazi, Sirajudeen K N S, Mohd Asnizam Asari, Swamy Mummedy, Mustapha Muzaimi, Siti Amrah Sulaiman
BACKGROUND: Administration of KA on rodents has resulted in seizures, behavioral changes, oxidative stress, and neuronal degeneration on selective population of neurons in the brain. The present study was undertaken to investigate the extent of neuroprotective effect conferred by Malaysian Tualang Honey (TH), an antioxidant agent, in the cerebral cortex of rats against KA-induced oxidative stress and neurodegeneration in an animal model of KA-induced excitotoxicity. METHODS: Male Sprague-Dawley rats were randomly divided into five groups: Control, KA-treated group, TH + KA-treated group, aspirin (ASP; anti-inflammatory agent) + KA-treated group and topiramate (TPM; antiepileptic agent) + KA-treated group...
January 9, 2017: BMC Complementary and Alternative Medicine
https://read.qxmd.com/read/27772925/inhibitory-effects-of-malaysian-tualang-honey-and-australian-new-zealand-manuka-honey-in-modulating-experimental-breast-cancers-induced-by-n-methyl-n-nitrosourea-mnu-a-comparative-study
#38
JOURNAL ARTICLE
Nor Hayati Othman, Sarfraz Ahmed, Siti Amrah Sulaiman
No abstract text is available yet for this article.
February 2016: Pathology
https://read.qxmd.com/read/27119005/tualang-honey-attenuates-noise-stress-induced-memory-deficits-in-aged-rats
#39
JOURNAL ARTICLE
Khairunnuur Fairuz Azman, Rahimah Zakaria, Che Badariah Abdul Aziz, Zahiruddin Othman
Ageing and stress exposure may lead to memory impairment while oxidative stress is thought to be one of the underlying mechanisms involved. This study aimed to investigate the potential protective effects of Tualang honey supplementation on memory performance in aged rats exposed to noise stress. Tualang honey supplementation was given orally, 200 mg/kg body weight for 28 days. Rats in the stress group were subjected to loud noise, 100 dB(A), 4 hours daily for 14 days. All rats were subjected to novel object recognition test for evaluation of memory performance...
2016: Oxidative Medicine and Cellular Longevity
https://read.qxmd.com/read/26803744/effect-of-tualang-honey-on-the-anastomotic-wound-healing-in-large-bowel-anastomosis-in-rats-a-randomized-controlled-trial
#40
JOURNAL ARTICLE
Muhammad Izani Aznan, Omaid Hayat Khan, Allah Obhayo Unar, Sharifah Emilia Tuan Sharif, Amer Hayat Khan, Syed Hassan Syed Abd Aziz, Andee Dzulkarnaen Zakaria
BACKGROUND: Honey has long been used for the treatment of number of ailments and diseases including surgical wounds. Current study evaluates the effectiveness of Tualang honey (TH) for large bowel anastomotic healing in Wistar rats. METHODS: Thirty male Wistar rats were given a 3 centimeter infra-umbilical laparotomy wound, in`flicted on their abdomen. The colonic transection was performed at 5 cm distal to caecum, with end to end anastomosis of colon segment. They were divided into two groups...
January 23, 2016: BMC Complementary and Alternative Medicine
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