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Tualang AND honey

Khairunnuur Fairuz Azman, Rahimah Zakaria, Che Badariah Abdul Aziz, Zahiruddin Othman
Ageing and stress exposure may lead to memory impairment while oxidative stress is thought to be one of the underlying mechanisms involved. This study aimed to investigate the potential protective effects of Tualang honey supplementation on memory performance in aged rats exposed to noise stress. Tualang honey supplementation was given orally, 200 mg/kg body weight for 28 days. Rats in the stress group were subjected to loud noise, 100 dB(A), 4 hours daily for 14 days. All rats were subjected to novel object recognition test for evaluation of memory performance...
2016: Oxidative Medicine and Cellular Longevity
Muhammad Izani Aznan, Omaid Hayat Khan, Allah Obhayo Unar, Sharifah Emilia Tuan Sharif, Amer Hayat Khan, Syed Hassan Syed Abd Aziz, Andee Dzulkarnaen Zakaria
BACKGROUND: Honey has long been used for the treatment of number of ailments and diseases including surgical wounds. Current study evaluates the effectiveness of Tualang honey (TH) for large bowel anastomotic healing in Wistar rats. METHODS: Thirty male Wistar rats were given a 3 centimeter infra-umbilical laparotomy wound, in`flicted on their abdomen. The colonic transection was performed at 5 cm distal to caecum, with end to end anastomosis of colon segment. They were divided into two groups...
2016: BMC Complementary and Alternative Medicine
Siti Sarah Mohamad Zaid, Normadiah M Kassim, Shatrah Othman
Bisphenol A (BPA) is an endocrine disrupting chemical (EDC) that can disrupt the normal functions of the reproductive system. The objective of the study is to investigate the potential protective effects of Tualang honey against BPA-induced uterine toxicity in pubertal rats. The rats were administered with BPA by oral gavage over a period of six weeks. Uterine toxicity in BPA-exposed rats was determined by the degree of the morphological abnormalities, increased lipid peroxidation, and dysregulated expression and distribution of ERα, ERβ, and C3 as compared to the control rats...
2015: Evidence-based Complementary and Alternative Medicine: ECAM
Nik Muhd Khuzaimi Nik Man, Rosline Hassan, Cheng Yong Ang, Abu Dzarr Abdullah, Muhammad Amiro Rasheeq Mohd Radzi, Siti Amrah Sulaiman
Complementary medicine using natural product as antitumor is on the rise. Much research has been performed on Tualang Honey and it was shown to have therapeutic potential in wound healing, and antimicrobial activity and be antiproliferative against several cancer models such as human osteosarcoma (HOS), human breast (MCF-7 and MDA-MB-231), and cervical (HeLa) cancer cell lines. To date, there was limited study on antileukemic properties of Tualang (Koompassia excelsa) Honey. The aim of this study was to evaluate the antileukemic effect of Tualang Honey on acute and chronic leukemia cell lines...
2015: BioMed Research International
Md Ibrahim Khalil, E M Tanvir, Rizwana Afroz, Siti Amrah Sulaiman, Siew Hua Gan
The present study was designed to investigate the cardioprotective effects of Malaysian Tualang honey against isoproterenol- (ISO-) induced myocardial infarction (MI) in rats by investigating changes in the levels of cardiac marker enzymes, cardiac troponin I (cTnI), triglycerides (TG), total cholesterol (TC), lipid peroxidation (LPO) products, and antioxidant defense system combined with histopathological examination. Male albino Wistar rats (n = 40) were pretreated orally with Tualang honey (3 g/kg/day) for 45 days...
2015: BioMed Research International
Baharudin Abdullah, Norhafiza Mat Lazim, Rosdan Salim
OBJECTIVES: This study aims to evaluate the effectiveness of Tualang honey in reducing post-tonsillectomy pain. PATIENTS AND METHODS: The study included 63 patients (31 males, 32 females; mean age 10±4.16 years; range 3 to 18 years) who were planned to undergo tonsillectomy. Patients were randomized into two groups. Treatment group received topical Tualang honey intraoperatively followed by oral consumption of Tualang honey three times daily for seven days with intravenous sultamicillin three times daily for first and second day followed by oral sultamicillin twice daily for five days...
2015: Kulak Burun Boğaz Ihtisas Dergisi: KBB, Journal of Ear, Nose, and Throat
Khairunnuur Fairuz Azman, Rahimah Zakaria, CheBadariah AbdAziz, Zahiruddin Othman, Badriya Al-Rahbi
Recent evidence has exhibited dietary influence on the manifestation of different types of behavior induced by stressor tasks. The present study examined the effects of Tualang honey supplement administered with the goal of preventing or attenuating the occurrence of stress-related behaviors in male rats subjected to noise stress. Forty-eight adult male rats were randomly divided into the following four groups: i) nonstressed with vehicle, ii) nonstressed with Tualang honey, iii) stressed with vehicle, and iv) stressed with honey...
March 2015: Noise & Health
Siti Sarah Mohamad Zaid, Shatrah Othman, Normadiah M Kassim
BACKGROUND: To investigate the potential protective effects of Tualang honey against the toxicity effects induced by Bisphenol A (BPA) on pubertal development of ovaries. METHODS: This study was conducted on pre-pubertal female Sprague Dawley rats. Animals were divided into four groups (n = 8 in each group). Group I was administered with vehicle 0.2 ml of corn oil (Sigma-Aldrich, USA) using oral gavage daily for six weeks; these animals served as negative control (CO group), Group II was administered with BPA suspended in corn oil at 10 mg/kg body weight and served as positive control (PC group), Group III was administered with 200 mg/kg body weight of Tualang honey 30 min before the administration of BPA at 10 mg/kg (TH group) while Group IV was administered with 200 mg/kg body weight of Tualang honey 30 min before the administration of corn oil (THC group)...
2014: BMC Complementary and Alternative Medicine
Shaiful Bahari Ismail, Mohd Bustamanizan Bakar, Nik Hazlina Nik Hussain, Mohd Noor Norhayati, Siti Amrah Sulaiman, Hasnan Jaafar, Samsul Draman, Roszaman Ramli, Wan Zahanim Wan Yusoff
Introduction. This study aims to evaluate the effectiveness of Tualang honey on sperm parameters, erectile function, and hormonal and safety profiles. Methodology. A randomized control trial was done using Tualang honey (20 grams) and Tribestan (750 mg) over a period of 12 weeks. Sperm parameters including sperm concentration, motility, and morphology were analyzed and erectile function was assessed using IIEF-5 questionnaire. Hormonal profiles of testosterone, FSH, and LH were studied. The volunteers were randomized into two groups and the outcomes were analyzed using SPSS version 18...
2014: Evidence-based Complementary and Alternative Medicine: ECAM
Wen-Jie Ng, Khai-Wei Ken, Roshani-Vijaya Kumar, Hemamalani Gunasagaran, Vanaysha Chandramogan, Ying-Yee Lee
BACKGROUND: Different researches on therapeutic effects of honey have been conducted in different regions; however the study on the potential antibacterial activity of Malaysian honey is still limited. In this study, antibacterial activities of different monofloral honey samples were tested against several common human pathogenic bacteria. MATERIALS AND METHODS: The well-diffusion method, minimum inhibitory concentrations (MIC) and minimum bactericidal concentration (MBC) techniques were employed to investigate the putative antibacterial activity of Malaysian monofloral honey from Koompassia excelsa (Becc...
2014: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
Che Badariah Abd Aziz, Che Aishah Nazariah Ismail, Che Maraina Che Hussin, Mahaneem Mohamed
Tualang honey ( Fēng Mì) is known to have anti-inflammatory property, but its antinociceptive property has not been extensively investigated. In this study, we examined the preemptive effects on administering different doses of Tualang honey and prednisolone on the nociceptive response in male Sprague-Dawley rats. Thirty-five male Sprague-Dawley rats were randomized into five groups (n = 7) and each group received either distilled water, Tualang honey (0.2, 1.2 or 2.4 g/kg) or prednisolone (10 mg/kg) for 10 days...
October 2014: Journal of Traditional and Complementary Medicine
Ozra Nasrolahi, Reza Heidari, Fatima Rahmani, Farah Farokhi
OBJECTIVE(S): Diabetes mellitus is a public health problem and one of the five leading causes of death globally. In the present study, the effect of Metformin with natural honey was investigated on glycemia in the Streptozotocin-induced diabetic rats. MATERIALS AND METHODS: Thirty Wistar male rats were randomly divided into six groups including C: non diabetic rats received distilled water, CH: non diabetic rats received honey, CD: diabetic rats administered with distilled water, DM: Metformin treated diabetic rats, DH: honey treated diabetic rats, and DMH: diabetic rats treated with a combination of Metformin and natural honey...
2012: Avicenna Journal of Phytomedicine
Jun Jie Tan, Siti Maisura Azmi, Yoke Keong Yong, Hong Leong Cheah, Vuanghao Lim, Doblin Sandai, Bakiah Shaharuddin
Stem cells with enhanced resistance to oxidative stress after in vitro expansion have been shown to have improved engraftment and regenerative capacities. Such cells can be generated by preconditioning them with exposure to an antioxidant. In this study we evaluated the effects of Tualang honey (TH), an antioxidant-containing honey, on human corneal epithelial progenitor (HCEP) cells in culture. Cytotoxicity, gene expression, migration, and cellular resistance to oxidative stress were evaluated. Immunofluorescence staining revealed that HCEP cells were holoclonal and expressed epithelial stem cell marker p63 without corneal cytokeratin 3...
2014: PloS One
Nik Soriani Yaacob, Nur Faezah Ismail
BACKGROUND: The Malaysian Tualang honey (TH) is not only cytotoxic to human breast cancer cell lines but it has recently been reported to promote the anticancer activity induced by tamoxifen in MCF-7 and MDA-MB-231 cells suggesting its potential as an adjuvant for the chemotherapeutic agent. However, tamoxifen produces adverse effects that could be due to its ability to induce cellular DNA damage. Therefore, the study is undertaken to determine the possible modulation of the activity of 4-hydroxytamoxifen (OHT), an active metabolite of tamoxifen, by TH in non-cancerous epithelial cell line, MCF-10A, in comparison with MCF-7 cells...
2014: BMC Complementary and Alternative Medicine
Badriya Al-Rahbi, Rahimah Zakaria, Zahiruddin Othman, Asma' Hassan, Asma Hayati Ahmad
A possible interaction between glucocorticoids and estrogen-induced increases in brain-derived-neurotrophic factor (BDNF) expression in enhancing depressive-like behaviour has been documented. Here we evaluated the effects of Tualang honey, a phytoestrogen, and 17 β -estradiol (E2) on the depressive-like behaviour, stress hormones, and BDNF concentration in stressed ovariectomised (OVX) rats. The animals were divided into six groups: (i) nonstressed sham-operated control, (ii) stressed sham-operated control, (iii) nonstressed OVX, (iv) stressed OVX, (v) stressed OVX treated with E2 (20  μg daily, sc), and (vi) stressed OVX treated with Tualang honey (0...
2014: TheScientificWorldJournal
Omotayo O Erejuwa
Diabetes mellitus remains an incurable disorder in spite of intense research. As result of limitations and unmet goals associated with the use of anti-diabetic drugs, an increased number of diabetic populations globally now resort to complementary and alternative medicine (CAM) such as herbs and other natural products. There has been a renewed interest in the use of honey in the treatment of diabetes mellitus, partly due to an increase in the availability of evidence-based data demonstrating its benefits in diabetic rodents and patients...
2014: Journal of Diabetes and Metabolic Disorders
M S Nurul Syazana, S H Gan, A S Halim, Nurul Syazana Mohamad Shah, Siew Hua Gan, Halim Ahmad Sukari
The constituents of honey's volatile compounds depend on the nectar source and differ depending on the place of origin. To date, the volatile constituents of Tualang honey have never been investigated. The objective of this study was to analyze the volatile compounds in local Malaysian Tualang honey. A continuous extraction of Tualang honey using five organic solvents was carried out starting from non-polar to polar solvents and the extracted samples were analysed using gas chromatography-mass spectrometry (GC-MS)...
2013: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
Lee Suan Chua, Norul Liza A Rahaman, Nur Ardawati Adnan, Ti Tjih Eddie Tan
The antioxidant activities based on the free radical scavenging, reducing power, and bleaching inhibition were investigated for the three commonly used honeys in Malaysia, namely, tualang, gelam, and acacia honey. The antioxidant capacity of the honey samples was correlated with their biochemical constituents such as total phenol, total flavonoid content, and total water-soluble vitamins (vitamin B1, B2, B3, B9, B12, and vitamin C). The total flavonoid content of honey samples was strongly correlated with the three antioxidative processes (r = 0...
2013: Journal of Analytical Methods in Chemistry
Sarfarz Ahmed, Nor Hayati Othman
Tualang honey (TH) is a Malaysian multifloral jungle honey. In recent years, there has been a marked increase in the number of studies published in medical databases regarding its potential health benefits. The honey is produced by the rock bee (Apis dorsata), which builds hives on branches of tall Tualang trees located mainly in the north-western region of Peninsular Malaysia. This review collates the results of the various studies of TH that range from research on tissue culture to randomised control clinical trials...
May 2013: Malaysian Journal of Medical Sciences: MJMS
Badriya Al-Rahbi, Rahimah Zakaria, Zahiruddin Othman, Asma Hassan, Zul Izhar Mohd Ismail, Sangu Muthuraju
Recently, our research team has reported that Tualang honey was able to improve immediate memory in postmenopausal women comparable with that of estrogen progestin therapy. Therefore the aim of the present study was to examine the effects of Tualang honey supplement on hippocampal morphology and memory performance in ovariectomized (OVX) rats exposed to social instability stress. Female Sprague-Dawley rats were divided into six groups: (i) sham-operated controls, (ii) stressed sham-operated controls, (iii) OVX rats, (iv) stressed OVX rats, (v) stressed OVX rats treated with 17β-estradiol (E2), and (vi) stressed OVX rats treated with Tualang honey...
January 2014: Acta Histochemica
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