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Dustin C Hancks
Chromothripsis is a mutational event driven by tens to hundreds of double-stranded DNA breaks which occur in a single event between a limited number of chromosomes. Following chromosomal shattering, DNA fragments are stitched together in a seemingly random manner resulting in complex genomic rearrangements including sequence shuffling, deletions, and inversions of varying size. This genomic catastrophe has been observed in cancer genomes and the genomes of patients harboring developmental and congenital defects...
2018: Methods in Molecular Biology
Frederic Picard, Angela Deakin, Navin Balasubramanian, Alberto Gregori
In this review, we outlined the definition of minimally invasive surgery (MIS) in total knee replacement (TKR) and described the different surgical approaches reported in the literature. Afterwards, we went through the most recent studies assessing MIS TKR. Next, we searched for potential limitations of MIS knee replacement and tried to answer the following questions: Are there selective criteria and specific patient selection for MIS knee surgery? If there are, then what are they? After all, a discussion and conclusion completed this article...
March 22, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
B Mazel-Sanchez, I Boal Carvalho, F Silva, R Dijkman, M Schmolke
Highly pathogenic IAV from avian hosts were first reported to directly infect humans 20 years ago. However, these are rare events and our understanding of factors promoting or restricting zoonotic transmission is still limited. One accessory protein of IAV, PB1-F2, was associated with pathogenicity of pandemic and zoonotic IAV. This 90-amino-acid-short peptide does not harbor an enzymatic function. We thus identified host factors interacting with H5N1 PB1-F2, which could explain its importance for virulence...
March 21, 2018: Journal of Virology
Paul McGreevy, Jeannine Berger, Nic de Brauwere, Orla Doherty, Anna Harrison, Julie Fiedler, Claudia Jones, Sue McDonnell, Andrew McLean, Lindsay Nakonechny, Christine Nicol, Liane Preshaw, Peter Thomson, Vicky Tzioumis, John Webster, Sarah Wolfensohn, James Yeates, Bidda Jones
The aim of this study was to conduct a series of paper-based exercises in order to assess the negative (adverse) welfare impacts, if any, of common interventions on domestic horses across a broad range of different contexts of equine care and training. An international panel (with professional expertise in psychology, equitation science, veterinary science, education, welfare, equestrian coaching, advocacy, and community engagement; n = 16) met over a four-day period to define and assess these interventions, using an adaptation of the domain-based assessment model...
March 18, 2018: Animals: An Open Access Journal From MDPI
Manuel Bratos, Jumping M Bergin, Jeffrey E Rubenstein, John A Sorensen
STATEMENT OF PROBLEM: Conventional impression techniques to obtain a definitive cast for a complete-arch implant-supported prosthesis are technique-sensitive and time-consuming. Direct optical recording with a camera could offer an alternative to conventional impression making. PURPOSE: The purpose of this in vitro study was to test a novel intraoral image capture protocol to obtain 3-dimensional (3D) implant spatial measurement data under simulated oral conditions of vertical opening and lip retraction...
March 17, 2018: Journal of Prosthetic Dentistry
Audrey R C Elias, Kari J Harris, Paul C LaStayo, Ryan L Mizner
BACKGROUND: Limited knee flexion and increased muscle co-contraction during jump landing are believed to diminish outcomes after anterior cruciate ligament (ACL) reconstruction. The efficacy of jump training to improve patients' mechanical and neuromuscular deficits is understudied. HYPOTHESIS: Jump training will improve functional, mechanical, and neuromuscular outcomes and higher repetition training augmented by body weight support will result in better retention of gains...
March 1, 2018: American Journal of Sports Medicine
Catarina S H Jesus, Pedro Fernandes Cruz, Luis G Arnaut, Rui M M Brito, Carlos Serpa
The understanding of fast folding dynamics of single α-helices comes mostly from studies on rationally designed peptides displaying sequences with high helical propensity. The folding/unfolding dynamics and energetics of α-helix conformations in naturally occurring peptides remains largely unexplored. Here we report the study of a protein fragment analogue of the C-peptide from bovine pancreatic ribonuclease-A, RN80, a 13-amino acid residue peptide that adopts a highly populated helical conformation in aqueous solution...
March 20, 2018: Journal of Physical Chemistry. B
Carlos Pomares-Noguera, Francisco Ayala, Francisco Javier Robles-Palazón, Juan F Alomoto-Burneo, Alejandro López-Valenciano, José L L Elvira, Sergio Hernández-Sánchez, Mark De Ste Croix
Objective: To analyze the training effects of the FIFA 11+ kids on several parameters of physical performance in male youth football players. Materials and methods: Twenty-three youth players were randomized within each team into two groups (control vs. intervention). The intervention group performed the FIFA 11+ kids programme 2 times a week for 4 weeks; the control groups completed their normal warm-up routines. Thirteen physical performance measures {range of motion (hip, knee, and ankle joints), dynamic postural control (measured throughout the Y balance test), 20 m sprint time, slalom dribble with a ball, agility, vertical jumping height [counter movement jump (CMJ) and drop jump (DJ)], horizontal jump distance, accuracy when volleying a ball [measured throughout the Wall Volley test]} were assessed...
2018: Frontiers in Pediatrics
Morten Kristoffersen, Øyvind Sandbakk, Espen Tønnessen, Ida Svendsen, Gøran Paulsen, Elisabeth Ersvær, Irene Nygård, Kari Rostad, Anita Ryningen, Vegard V Iversen, Knut Skovereng, Bent R Rønnestad, Hilde Gundersen
Purpose: Although strength and sprint training are widely used methods in competitive cycling, no previous studies have compared the acute responses and recovery rates following such sessions among highly trained cyclists. The primary aim of the current study was to compare power production and biochemical markers of metabolic stress and muscle damage following a session of heavy strength (HS) and short-sprint training (SS). Methods: Eleven well-trained male cyclists (18 ± 2 years with maximal oxygen uptake of 67...
2018: Frontiers in Physiology
R S MacKay, J D Robinson
A Markov flow is a stationary measure, with the associated flows and mean first passage times, for a continuous-time regular jump homogeneous semi-Markov process on a discrete state space. Nodes in the state space can be eliminated to produce a smaller Markov flow which is a factor of the original one. Some improvements to the elimination methods of Wales are given. The main contribution of the paper is to present an alternative, namely a method to aggregate groups of nodes to produce a factor. The method can be iterated to make hierarchical aggregation schemes...
April 28, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
Biao Xie, Yongqi Zhang, Haikun Huang, Elisa Ogawa, Tongjian You, Lap-Fai Yu
Games and experiences designed for virtual or augmented reality usually require the player to move physically to play. This poses substantial challenge for level designers because the player's physical experience in a level will need to be considered, otherwise the level may turn out to be too exhausting or not challenging enough. This paper presents a novel approach to optimize level designs by considering the physical challenge imposed upon the player in completing a level of motion-based games. A game level is represented as an assembly of chunks characterized by the exercise intensity levels they impose on players...
April 2018: IEEE Transactions on Visualization and Computer Graphics
Thais Regina de Mattos Lourenco, Priscila Katsumi Matsuoka, Edmund Chada Baracat, Jorge Milhem Haddad
INTRODUCTION AND HYPOTHESIS: People are increasingly aware of healthy lifestyles. Extenuating practice can injure the pelvic floor. Urinary incontinence (UI) is a prevalent condition in women whether they exercise professionally or not. The most common symptom is stress UI. It is reported in a large variety of sports and may interfere with everyday life or training, leading athletes to change or compromise their performance or risk compromising it. We aimed to assess the prevalence of UI in female athletes and to determine whether the type of sport might also influence UI...
March 19, 2018: International Urogynecology Journal
Marie E Boo, J Craig Garrison, Joseph P Hannon, Kalyssa M Creed, Shiho Goto, Angellyn N Grondin, James M Bothwell
Background: Female patients are more likely to suffer a second anterior cruciate ligament (ACL) injury after ACL reconstruction (ACLR) and return to sport (RTS) compared with healthy female controls. Few studies have examined the energy absorption contribution (EAC) that could lead to this subsequent injury. Hypothesis: The ACLR group would demonstrate an altered EAC between joints (hip, knee, and ankle) but no difference in quadriceps, hip abduction, or hip external rotation (ER) strength at the time of RTS...
March 2018: Orthopaedic Journal of Sports Medicine
Olaf Prieske, Tom Krüger, Markus Aehle, Erik Bauer, Urs Granacher
Power training programs have proved to be effective in improving components of physical fitness such as speed. According to the concept of training specificity, it was postulated that exercises must attempt to closely mimic the demands of the respective activity. When transferring this idea to speed development, the purpose of the present study was to examine the effects of resisted sprint (RST) vs. traditional power training (TPT) on physical fitness in healthy young adults. Thirty-five healthy, physically active adults were randomly assigned to a RST ( n = 10, 23 ± 3 years), a TPT ( n = 9, 23 ± 3 years), or a passive control group ( n = 16, 23 ± 2 years)...
2018: Frontiers in Physiology
Daniel John Cleather
The patella is traditionally understood to be a "joint spacer" that increases the moment arm of the patellar tendon. This characterisation is unsatisfactory as it fails to explain the more interesting characteristics of the patella: 1) that the changing pivot point of the patella causes the ratio of quadriceps to patellar tendon force to almost double as the knee flexes; 2) that the patellar tendon exerts an anteriorly directed force on the tibia when the knee is extended but this switches to a posterior draw as the knee flexes; and 3) that the presence of the patella allows the quadriceps to exert different moments on the femur and tibia...
March 13, 2018: Journal of Theoretical Biology
Lachlan P James, Paul Comfort, Timothy J Suchomel, Vincent G Kelly, Emma M Beckman, G Gregory Haff
The purpose of this investigation was to determine whether weightlifting actions are a viable method for improving athletic performance amongst weaker, inexperienced lifters when compared to individuals with a greater power clean result, and hence weightlifting ability and experience. Two groups of males with distinctly different power clean performances (higher performance (HP): N = 8; BM = 78.1±4.0 kg; 1RM PC = 1.08±0.09 kgBM; lower performance (LP): N = 8; BM=82.6±14.0 kg; 1RM PC=0.78±0.1 kg·BM) and resistance training age (HP: resistance training experience=3...
March 14, 2018: Journal of Strength and Conditioning Research
Yongxi Ou, D C Ralph, R A Buhrman
Robust spin Hall effects (SHE) have recently been observed in nonmagnetic heavy metal systems with strong spin-orbit interactions. These SHE are either attributed to an intrinsic band-structure effect or to extrinsic spin-dependent scattering from impurities, namely, side jump or skew scattering. Here we report on an extraordinarily strong spin Hall effect, attributable to spin fluctuations, in ferromagnetic Fe_{x}Pt_{1-x} alloys near their Curie point, tunable with x. This results in a dampinglike spin-orbit torque being exerted on an adjacent ferromagnetic layer that is strongly temperature dependent in this transition region, with a peak value that indicates a lower bound 0...
March 2, 2018: Physical Review Letters
Oneida Espinosa-Álvarez, Paola A Ortiz, Luciana Lima, André G Costa-Martins, Myrna G Serrano, Stephane Herder, Gregory A Buck, Erney P Camargo, Patrick B Hamilton, Jamie R Stevens, Marta M G Teixeira
Trypanosoma rangeli and Trypanosoma cruzi are generalist trypanosomes sharing a wide range of mammalian hosts; they are transmitted by triatomine bugs, and are the only trypanosomes infecting humans in the Neotropics. Their origins, phylogenetic relationships, and emergence as human parasites have long been subjects of interest. In the present study, taxon-rich analyses (20 trypanosome species from bats and terrestrial mammals) using ssrRNA, glycosomal glyceraldehyde-3-phosphate dehydrogenase (gGAPDH), heat shock protein-70 (HSP70) and Spliced Leader (SL) RNA sequences, and multilocus phylogenetic analyses using 11 single copy genes from 15 selected trypanosomes, provide increased resolution of relationships between species and clades, strongly supporting two main sister lineages: lineage Schizotrypanum, comprising T...
March 12, 2018: International Journal for Parasitology
Nilam Borah, Emad Albarouki, Jan Schirawski
Many plant-pathogenic fungi are highly host-specific. In most cases, host-specific interactions evolved at the time of speciation of the respective host plants. However, host jumps have occurred quite frequently, and still today the greatest threat for the emergence of new fungal diseases is the acquisition of infection capability of a new host by an existing plant pathogen. Understanding the mechanisms underlying host-switching events requires knowledge of the factors determining host-specificity. In this review, we highlight molecular methods that use a comparative approach for the identification of host-specificity factors...
March 15, 2018: International Journal of Molecular Sciences
Christian Møller Madsen, Benjamin Badault, Lars Nybo
Badminton-specific speed and endurance performance was evaluated in both cross-sectional and longitudinal studies of elite youth players and compared to the physiological capacities of world top-50 singles players.The cross-sectional study involved ten males in the category U15 (<15 years), ten U17, nine U19 and four senior elite players. They performed 30-m sprint, counter-movement jump (CMJ) and badminton-specific speed (B-SPEED) and endurance (B-ENDURANCE) tests. The longitudinal data were collected for ten U15 players with 1- and 2-year follow-up measures...
March 13, 2018: Journal of Strength and Conditioning Research
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