Lauren Siegel, Han Yan, Nebras Warsi, Simeon Wong, Hrishikesh Suresh, Alexander G Weil, John Ragheb, Shelly Wang, Curtis Rozzelle, Gregory W Albert, Jeffrey Raskin, Taylor Abel, Jason Hauptman, Dewi V Schrader, Robert Bollo, Matthew D Smyth, Sean M Lew, Melissa Lopresti, Dominic J Kizek, Howard L Weiner, Aria Fallah, Elysa Widjaja, George M Ibrahim
INTRODUCTION: Vagus nerve stimulation (VNS) is a neuromodulation therapy that can reduce the seizure burden of children with medically intractable epilepsy. Despite the widespread use of VNS to treat epilepsy, there are currently no means to preoperatively identify patients who will benefit from treatment. The objective of the present study is to determine clinical and neural network-based correlates of treatment outcome to better identify candidates for VNS therapy. METHODS AND ANALYSIS: In this multi-institutional North American study, children undergoing VNS and their caregivers will be prospectively recruited...
April 8, 2022: BMJ Open