keyword
https://read.qxmd.com/read/38331658/intraoperative-pharmacologic-opioid-minimisation-strategies-and-patient-centred-outcomes-after-surgery-a-scoping-review
#1
REVIEW
Michael Verret, Nhat H Lam, Manoj Lalu, Stuart G Nicholls, Alexis F Turgeon, Daniel I McIsaac, Myriam Hamtiaux, John Bao Phuc Le, Ian Gilron, Lucy Yang, Mahrukh Kaimkhani, Alexandre Assi, David El-Adem, Makenna Timm, Peter Tai, Joelle Amir, Sriyathavan Srichandramohan, Abdulaziz Al-Mazidi, Nicholas A Fergusson, Brian Hutton, Fiona Zivkovic, Megan Graham, Maxime Lê, Allison Geist, Mélanie Bérubé, Patricia Poulin, Risa Shorr, Helena Daudt, Guillaume Martel, Jason McVicar, Husein Moloo, Dean A Fergusson
BACKGROUND: Postoperative patient-centred outcome measures are essential to capture the patient's experience after surgery. Although a large number of pharmacologic opioid minimisation strategies (i.e. opioid alternatives) are used for patients undergoing surgery, it remains unclear which strategies are most promising in terms of patient-centred outcome improvements. This scoping review had two main objectives: (1) to map and describe evidence from clinical trials assessing the patient-centred effectiveness of pharmacologic intraoperative opioid minimisation strategies in adult surgical patients, and (2) to identify promising pharmacologic opioid minimisation strategies...
February 7, 2024: British Journal of Anaesthesia
https://read.qxmd.com/read/38158251/diagnostic-accuracy-of-the-pediatric-cam-icu-pre-school-cam-icu-pediatric-anesthesia-emergence-delirium-and-cornell-assessment-of-pediatric-delirium-for-detecting-delirium-in-the-pediatric-intensive-care-unit-a-systematic-review-and-meta-analysis
#2
REVIEW
Iftitakhur Rohmah, Yi-Chen Chen, Chia-Jou Lin, Nan-Hsuan Tsao, Hsiao-Yean Chiu
OBJECTIVES: Delirium is a frequent complication of critical illness, affecting 34% of children admitted to pediatric intensive care units. The commonly used tools for detecting delirium in the pediatric intensive care unit include the Pediatric Confusion Assessment Method for the intensive care unit (ICU, pCAM-ICU), Preschool Confusion Assessment Method for the ICU (psCAM-ICU), Pediatric Anesthesia Emergence Delirium and the Cornell Assessment of Pediatric Delirium. DATA SOURCES: We searched four electronic databases for relevant articles from inception to March 1, 2023...
December 28, 2023: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://read.qxmd.com/read/38153857/trends-in-gender-of-authors-of-patient-blood-management-publications
#3
JOURNAL ARTICLE
Katherine T Forkin, Caroline M Render, Steven J Staffa, Susan M Goobie
BACKGROUND: Diverse representation in the field of patient blood management (PBM) may help bring varying perspectives to improve patient care. We assessed trends in gender of first and last authorship of recent PBM publications to evaluate diversity within the field. METHODS: Publications from 10 high-impact anesthesiology and blood transfusion medicine journals between 2017 and 2021 were reviewed using 19 keywords to identify PBM-related articles. Each publication title was reviewed independently to determine whether it met the inclusion criteria...
December 28, 2023: Anesthesia and Analgesia
https://read.qxmd.com/read/38107753/the-analgesic-effect-of-transmuscular-quadratus-lumborum-block-versus-erector-spinae-plane-block-for-women-undergoing-elective-caesarean-section-a-randomized-controlled-trial
#4
JOURNAL ARTICLE
Maha Mostafa, Mohamed A Nasr, Maher Fawzy, Aya E Awad, Mohsen M Waheeb
BACKGROUND: We aimed to compare the analgesic effect and quality of recovery of transmuscular quadratus lumborum block (QLB) and erector spinae plane block (ESPB) in the presence of multimodal analgesia following Caesarean section. METHODS: This randomised controlled trial included full-term pregnant women who underwent elective Caesarean section under spinal anaesthesia without intrathecal morphine. The included women were randomised to receive either bilateral QLB ( n = 51) or bilateral thoracic ESPB ( n = 51), in addition to the control group ( n = 51) who did not receive any block...
October 2023: British Journal of Pain
https://read.qxmd.com/read/38087740/age-and-its-impact-on-crisis-management-performance-and-learning-after-simulation-based-education-by-acute-care-physicians-a-multicentre-prospective-cohort-study
#5
JOURNAL ARTICLE
Fahad Alam, Vicki R LeBlanc, Alan Baxter, Jordan Tarshis, Dominique Piquette, Yuqi Gu, Caroline Filipowska, Ashley Krywenky, Nicole Kester-Greene, Pierre Cardinal, Meghan Andrews, Francois Chartier, Claire Burrows, Charles-Henri Houzé-Cerfon, Joseph K Burns, Lilia Kaustov, Shelly Au, Sandy Lam, Susan DeSousa, Sylvain Boet
BACKGROUND: Physiological changes associated with ageing could negatively impact the crisis resource management skills of acute care physicians. This study was designed to determine whether physician age impacts crisis resource management skills, and crisis resource management skills learning and retention using full-body manikin simulation training in acute care physicians. METHODS: Acute care physicians at two Canadian universities participated in three 8-min simulated crisis (pulseless electrical activity) scenarios...
December 12, 2023: British Journal of Anaesthesia
https://read.qxmd.com/read/38065797/efficacy-of-bilateral-oc-01-varenicline-solution-nasal-spray-in-alleviating-signs-and-symptoms-of-dry-eye-disease-a-systematic-review
#6
REVIEW
Antonio Ballesteros-Sánchez, Davide Borroni, Concepción De-Hita-Cantalejo, María Carmen Sánchez-González, Serafin Sanchez-Gomez, Carlos Rocha-de-Lossada, José-María Sánchez-González
PURPOSE: To comprehensively review the efficacy and safety of OC-01 varenicline nasal spray versus vehicle nasal spray (VNS) in the treatment in dry eye disease (DED). METHODS: A systematic review that included full-length randomized controlled studies (RCTs), as well as post hoc analyses of RCTs reporting new findings on OC-01 VNS treatment in three databases, PubMed, Scopus and Web of Science, was performed according to the PRISMA statement. The search period included studies published between December 2021 and September 2023...
December 7, 2023: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://read.qxmd.com/read/37949367/a-retrospective-cohort-study-of-adverse-maternal-and-newborn-outcomes-at-rural-hospitals-that-participated-in-the-rural-surgical-and-obstetrical-networks-rson-of-british-columbia-2016-2021
#7
JOURNAL ARTICLE
Kathrin Stoll, Tessa A Bendyshe-Walton, Gal Av-Gay, Anshu Parajulee, Nancy Humber, Kim Williams, Tom Skinner, Jude Kornelsen
BACKGROUND: The goal of the Rural Surgical and Obstetrical Networks (RSON) of British Columbia was to support safe and appropriate surgery, operative birth, and perinatal care closer to home for rural communities. Family physicians with enhanced obstetrical and/or surgical skills provide caesarean sections and family practice anesthetists (FPA) manage anesthesia for labour pain and operative births at RSON supported hospitals, with involvement of a local specialist at one site. OBJECTIVES: 1) To compare perinatal outcomes at hospitals participating in the RSON initiative with outcomes at referral hospitals and 2) to examine temporal changes in the proportion of childbearing people who resided in RSON communities and gave birth locally...
November 8, 2023: Journal of Obstetrics and Gynaecology Canada: JOGC
https://read.qxmd.com/read/37937771/patient-selection-and-outcome-of-deep-brain-stimulation-for-multiple-sclerosis-associated-tremor
#8
JOURNAL ARTICLE
Menaka Pasangy Paranathala, Russell Mills, Priya Rai, Nicola Pavese, Mohammed Akbar Hussain, Martin Duddy, Claire Nicholson, Alistair Jenkins
INTRODUCTION: Tremor is a disabling symptom of multiple sclerosis (MS), with limited treatment modalities. Thalamic ventral-intermediate-nucleus (VIM) deep brain stimulation (DBS) is a method of neuromodulation. We describe the long-term outcomes of our carefully selected patients who underwent VIM DBS for their MS-associated tremor. METHODS: Patients were referred from the regional neurology units. Pre-operative assessments included suitability for anesthesia, tremor quantification by the Fahn-Tolosa-Marin scores, and quality-of-life (EQ5D) measures...
November 8, 2023: British Journal of Neurosurgery
https://read.qxmd.com/read/37716888/basic-analgesic-use-in-randomised-trials-assessing-local-and-regional-analgesic-interventions-for-mastectomy-a-critical-appraisal-and-clinical-implications
#9
REVIEW
Dan Mija, Henrik Kehlet, Girish P Joshi
Regional analgesia is a core component of an optimal multimodal analgesia technique. Several advanced regional analgesic techniques have been evaluated for mastectomy; however, the optimal choice remains unclear. Many randomised clinical trials (RCTs) evaluating various local/regional analgesic techniques do not include basic analgesics (i.e. paracetamol, non-steroidal anti-inflammatory drugs, cyclooxygenase-2 specific inhibitors, and dexamethasone) which precludes objective evaluation of their efficacy. The aim of this scoping review was to assess the use of basic analgesics in RCTs evaluating efficacy of local and regional analgesic techniques in patients undergoing mastectomy...
November 2023: British Journal of Anaesthesia
https://read.qxmd.com/read/37601497/the-p-value-and-its-historical-underpinnings-pro-and-con
#10
REVIEW
Victor Grech, Adelazeem A Eldawlatly
UNLABELLED: The derivation and interpretation of P values derived from inferential testing remain somewhat vague and ambiguous in the minds of some researchers/editors/reviewers/readers. The British polymath Fisher famously averred: "the value for which P = 0.05, or 1 in 20, is 1.96 or nearly 2; it is convenient to take this point as a limit in judging whether a deviation is to be considered significant or not. Deviations exceeding twice the standard deviation are thus formally regarded as significant...
2023: Saudi Journal of Anaesthesia
https://read.qxmd.com/read/37561351/lowering-the-statistical-significance-threshold-of-randomized-controlled-trials-in-three-major-general-anesthesiology-journals
#11
JOURNAL ARTICLE
Philo Waters, Brayden Rucker, Mitchell Love, Matt Vassar
PURPOSE: The primary objective of our study was to determine how lowering a P value threshold from 0.05 to 0.005 would affect the statistical significance of previously published randomized controlled trials (RCTs) in major anesthesiology journals. METHODS: We searched the PubMed database for studies electronically published in 2020 within three major general anesthesiology journals as indexed by both Google Metrics and Scimago Journal & Country Rank. Studies included were RCTs published in 2020 in Anesthesiology, Anesthesia & Analgesia, and the British Journal of Anaesthesia; had a primary endpoint, and used a P value threshold to determine the effect of the intervention...
August 10, 2023: Canadian Journal of Anaesthesia
https://read.qxmd.com/read/37538943/the-effect-of-pregabalin-on-postoperative-pain-after-anterior-cruciate-ligament-reconstruction-a-systematic-review-of-randomized-clinical-trials
#12
JOURNAL ARTICLE
Seyyed Morteza Kazemi, Emad Kouhestani, Seyyed Mehdi Hosseini
BACKGROUND: Despite the enormous success of anterior cruciate ligament (ACL) reconstruction, acute neuropathic pain can develop postoperatively and is both distressing and difficult to treat once established. Pregabalin, an anticonvulsant agent that selectively affects the nociceptive process, has been used as a pain relief agent. The purpose of this systematic review of randomized controlled trials (RCTs) was to evaluate the pain control effect of pregabalin versus placebo after ACL reconstruction...
August 2023: British Journal of Pain
https://read.qxmd.com/read/37537117/sevoflurane-anaesthesia-induces-cognitive-impairment-in-young-mice-through-sequential-tau-phosphorylation
#13
JOURNAL ARTICLE
Feng Liang, Mengzhu Li, Miao Xu, Yiying Zhang, Yuanlin Dong, Sulpicio G Soriano, Mary Ellen McCann, Guang Yang, Zhongcong Xie
BACKGROUND: The volatile anaesthetic sevoflurane induces time (single or multiple exposures)-dependent effects on tau phosphorylation and cognitive function in young mice. The underlying mechanism for this remains largely undetermined. METHODS: Mice received 3% sevoflurane for 0.5 h or 2 h daily for 3 days on postnatal day (P) 6, 9, and 12. Another group of mice received 3% sevoflurane for 0.5 h or 1.5 h (3 × 0.5) on P6. We investigated effects of sevoflurane anaesthesia on tau phosphorylation on P6 or P12 mice, on cognitive function from P31 to P37, and on protein interactions, using in vivo studies, in vitro phosphorylation assays, and nanobeam single-molecule level interactions in vitro...
October 2023: British Journal of Anaesthesia
https://read.qxmd.com/read/37536932/bioinformatics-guided-disproportionality-analysis-of-sevoflurane-induced-nephrogenic-diabetes-insipidus-using-the-fda-adverse-event-reporting-system-faers-database
#14
JOURNAL ARTICLE
Akhil T Jacob, Ankitha Hari Kumar, H Gayethri, Lipin Lukose, Gouri Nair, Subeesh Kulangara Viswam
AIM: Sevoflurane is an ether-based inhalational anesthetic that induces and maintains general anesthesia. Our study aimed to detect sevoflurane-induced nephrogenic diabetes insipidus using Data Mining Algorithms (DMAs) and molecular docking. The FAERS database was analyzed using OpenVigil 2.1 for disproportionality analysis. METHODS: We analyzed FAERS data from 2004 to 2022 to determine the incidence of nephrogenic diabetes insipidus associated with sevoflurane...
August 3, 2023: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/37468157/evaluating-trends-in-private-equity-ownership-and-impacts-on-health-outcomes-costs-and-quality-systematic-review
#15
JOURNAL ARTICLE
Alexander Borsa, Geronimo Bejarano, Moriah Ellen, Joseph Dov Bruch
OBJECTIVE: To review the evidence on trends and impacts of private equity (PE) ownership of healthcare operators. DESIGN: Systematic review. DATA SOURCES: PubMed, Web of Science, Embase, Scopus, and SSRN. ELIGIBILITY CRITERIA FOR STUDY SELECTION: Empirical research studies of any design that evaluated PE owned healthcare operators. MAIN OUTCOME MEASURES: The main outcome measures were impact of PE ownership on health outcomes, costs to patients or payers, costs to operators, and quality...
July 19, 2023: BMJ: British Medical Journal
https://read.qxmd.com/read/37309663/drug-drug-interaction-of-ciprofol-injectable-emulsion-with-mefenamic-acid-capsules-in-healthy-subjects
#16
JOURNAL ARTICLE
Dandan Yang, Yin Hu, Zourong Ruan, Bo Jiang, Haiying Wang, Yichao Xu, Mengyue Hu, Min Yan, Honggang Lou
AIMS: To investigate the drug-drug interaction (DDI) of ciprofol injectable emulsion between mefenamic acid capsules in healthy subjects. METHODS: Twenty healthy subjects were enrolled in this single-center, open-label, two-period DDI study. Ciprofol (0.4 mg・kg-1 ) was administered as a single dose on days 1 and 5. A 500 mg oral loading dose of mefenamic acid was given on day 4 followed by a 250 mg maintenance dose every 6 h (total, eight doses). Blood samples for pharmacokinetic analyses were collected...
June 13, 2023: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/37005203/rotational-thromboelastometry-guided-use-of-synthetic-blood-products-in-cardiac-transplant-patients-a-retrospective-before-after-study
#17
JOURNAL ARTICLE
Kimberly C Li, Matthew A Coley, Anthony Chau, Alexander Dotto, Andrew McMillan, Hsian Chiu, Ronald Ree
OBJECTIVES: Viscoelastic hemostatic assays, such as rotational thromboelastometry (ROTEM), are used increasingly in cardiac surgery to guide transfusion decisions. After separation from cardiopulmonary bypass (CPB), achieving hemostasis rapidly is the main goal before chest closure. The authors hypothesized that introducing a ROTEM-guided factor- concentrate transfusion algorithm would reduce the duration from CPB separation to chest closure during cardiac transplantation. DESIGN: A retrospective cohort study of 21 patients before and 28 patients after implementation of the ROTEM-guided transfusion algorithm who underwent cardiac transplantation...
July 2023: Journal of Cardiothoracic and Vascular Anesthesia
https://read.qxmd.com/read/36967651/effect-of-esketamine-on-opioid-consumption-and-postoperative-pain-in-thyroidectomy-a-randomized-controlled-trial
#18
JOURNAL ARTICLE
Penglei Wang, Meixian Song, Xiaoli Wang, Ye Zhang, Yun Wu
AIMS: Thyroidectomy is frequently associated with substantial postoperative pain. Esketamine, an N-methyl-d-aspartate receptor antagonist, has been demonstrated to be effective in multiple analgesia scenarios. We hypothesized that intraoperative administration of esketamine may reduce perioperative opioid consumption and postoperative pain in patients undergoing thyroidectomy. METHODS: Sixty patients undergoing thyroidectomy were randomly assigned to two groups...
March 26, 2023: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/36932845/procedural-sedation-for-pediatric-patients-with-spinal-muscular-atrophy-undergoing-intrathecal-treatment
#19
JOURNAL ARTICLE
Feyza Sever, Sengül Özmert, Nefise Arıbaş Öz
AIMS: Nusinersen is administered intrathecally for treating spinal muscular atrophy (SMA). Procedural sedation is common with intrathecal treatment in children. The purpose of this study is to emphasize that intrathecal treatment of pediatric patients with SMA I, II, and III can be tolerated with procedural sedation instead of general anesthesia. METHODS: Data were collected the from the anesthesia charts and electronic medical records of 14 pediatric patients with SMA types I, II, and III who underwent procedural sedation for repeated intrathecal treatments for SMA...
March 18, 2023: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/36912109/efficacy-of-fascia-iliaca-compartment-blocks-in-proximal-femoral-fractures-in-the-prehospital-setting-a-systematic-review-and-meta-analysis
#20
REVIEW
Sabrina Slade, Evan Hanna, Josh Pohlkamp-Hartt, David W Savage, Robert Ohle
INTRODUCTION: Proximal femoral fractures are characterized as one of the most common and most painful injuries sustained by patients of all ages and are associated with high rates of oligoanalgesia in the prehospital setting. Current treatments include oral and parenteral opiates and sedative agents, however regional anesthesia techniques for pain relief may provide superior analgesia with lower risk of side effects during patient transportation. The fascia iliaca compartment block (FICB) is an inexpensive treatment which is performed with minimal additional equipment, ultimately making it suitable in prehospital settings...
April 2023: Prehospital and Disaster Medicine
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