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Nor epinephrine

Sarah J Hall, Sally A Ferguson, Anne I Turner, Samuel J Robertson, Grace E Vincent, Brad Aisbett
On-call work is becoming an increasingly common work pattern, yet the human impacts of this type of work are not well established. Given the likelihood of calls to occur outside regular work hours, it is important to consider the potential impact of working on-call on stress physiology and sleep. The aims of this review were to collate and evaluate evidence on the effects of working on-call from home on stress physiology and sleep. A systematic search of Ebsco Host, Embase, Web of Science, Scopus and ScienceDirect was conducted...
June 11, 2016: Sleep Medicine Reviews
N M Abdel-Hamid, Dalia E Shehata, Ahmed A Abdel-Ghany, Ahmed Ragaa, Ahmed Wahid
Hepatocellular carcinoma (HCC) is the primary cancer of the liver. The present study aimed to assess the potential role of the endogenous regulators of angiogenesis like neurotransmitters, as possible HCC biomarkers. Five groups of rats were used in this study (8 rats per each): control healthy group (I), four intoxicated groups (II, III, IV, and V) used for induction of HCC with a single IP dose of diethylnitrosamine (DENA), 200mg/kg. Groups II, III, IV, and V were sacrificed after 8, 16, 24, and 32 weeks of DENA injection respectively...
July 14, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Marisa Sukapattee, Sitthichai Wanachantararak, Varisara Sirimaharaj, Noppakun Vongsavan, Bruce Matthews
OBJECTIVE: To determine if full crown preparation causes an increase in pulpal blood flow (PBF), indicating inflammation, in human subjects. DESIGN: The experiments were carried out on 35 intact, mandibular posterior teeth in 13 subjects: 32 were abutments for 16 fixed bridges that replaced first molars; the other 3 were first premolars adjacent to abutment teeth that served as un-operated controls. Crown preparations were made using an air-rotor with water-spray under regional block anaesthesia (4% articaine with epinephrine 1:100,000)...
June 7, 2016: Archives of Oral Biology
Désirée Larenas-Linnemann
Due to differences between allergen immunotherapy (AIT) trials in patient populations, trial design (including primary efficacy variables), the definition of a pollen season, data analysis, and comparisons between AIT products with existing data, is not possible nor valid. The efficacy of two grass pollen AIT tablets, Oralair(®) and Grazax(®)/Grastek(®), should not be compared by looking at the percentage of score improvement in their respective trials. However, the evidence available concerning the efficacy and safety in trials can be compared by paying close attention to the scientific quality of the trials, details in the administration schedules, and safety issues...
2016: Therapeutics and Clinical Risk Management
Kristina Eisinger, Lisa Rein-Fischboeck, Rebekka Pohl, Elisabeth M Meier, Sabrina Krautbauer, Christa Buechler
The scaffold protein alpha-syntrophin (SNTA) regulates lipolysis indicating a role in lipid homeostasis. Adipocytes are the main lipid storage cells in the body, and here, the function of SNTA has been analyzed in 3T3-L1 cells. SNTA is expressed in preadipocytes and is induced early during adipogenesis. Knock-down of SNTA in preadipocytes increases their proliferation. Proteins which are induced during adipogenesis like adiponectin and caveolin-1, and the inflammatory cytokine IL-6 are at normal levels in the mature cells differentiated from preadipocytes with low SNTA...
July 1, 2016: Experimental Cell Research
Mónica Moreira-Rodrigues, Priscila Mendes, Ana L Graça, Raquel Martinho, Paula Serrão, Daniel Moura
AIMS: Epinephrine is unique among biogenic catecholamines as a potent agonist of β2-adrenoceptors. The β2-adrenoceptor mediated effects during development might be linked to the increase of epinephrine synthesis. Our purpose was to characterize β-adrenoceptor-mediated relaxation in the aorta of newborn and young rabbits (3 to 4months old), and to relate those responses with the epinephrine content of the adrenal gland. MAIN METHODS: The epinephrine levels and the tyrosine hydroxylase activity were determined in adrenal glands of newborn and young rabbits...
July 1, 2016: Life Sciences
R Grace Walton, Xiaolin Zhu, Ling Tian, Elizabeth B Heywood, Jian Liu, Helliner S Hill, Jiarong Liu, Dennis Bruemmer, Qinglin Yang, Yuchang Fu, W Timothy Garvey
The NR4A orphan nuclear receptors function as early response genes to numerous stimuli. Our laboratory has previously demonstrated that overexpression of NR4A3 (NOR-1, MINOR) in 3T3-L1 adipocytes enhances insulin-stimulated glucose uptake. To assess the in vivo effect of NR4A3 on adipocytes, we generated transgenic mice with NR4A3 overexpression driven by the adipocyte fatty acid-binding protein (AP2) promoter (AP2-NR4A3 mice). We hypothesized that AP2-NR4A3 mice would display enhanced glucose tolerance and insulin sensitivity...
July 1, 2016: American Journal of Physiology. Endocrinology and Metabolism
Michelle Sinclair, Tamara Keeley, Anne-Cecile Lefebvre, Clive J C Phillips
Rodeos are public events at which stockpeople face tests of their ability to manage cattle and horses, some of which relate directly to rangeland cattle husbandry. One of these is calf roping, in which a calf released from a chute is pursued by a horse and rider, who lassoes, lifts and drops the calf to the ground and finally ties it around the legs. Measurements were made of behavior and stress responses of ten rodeo-naïve calves marshalled by a horse and rider, and ten rodeo-experienced calves that were roped...
2016: Animals: An Open Access Journal From MDPI
Susan Joseph, Maria Rosa Costanzo
Central sleep apnea is a devastating disease which occurs in approximately 40% of patients with heart failure as well as patients with a history of stroke, opioid use and neurological conditions. It is associated with increased morbidity and mortality in heart failure likely due to the recurrent episodes of hypoxia and nor-epinephrine release. There have historically been few therapeutic options; positive airway pressure therapies have been the most common treatment to date. However, the adoption of positive airway pressure therapies has been limited due to poor patient adherence and acceptance and recent evidence of increased cardiovascular mortality in low ejection fraction heart failure patients with CSA...
March 2016: International Journal of Cardiology
Aditee P Ambardekar, Devika Singh, Justin L Lockman, David L Rodgers, Roberta L Hales, Harshad G Gurnaney, Aruna Nathan, Ellen S Deutsch
BACKGROUND: Pediatric anesthesiologists must manage crises in neonates and children with timely responses and limited margin for error. Teaching the range of relevant skills during a 12-month fellowship is challenging. An experiential simulation-based curriculum can augment acquisition of knowledge and skills. OBJECTIVES: To develop a simulation-based boot camp (BC) for novice pediatric anesthesiology fellows and assess learner perceptions of BC activities. We hypothesize that BC is feasible, not too basic, and well received by fellows...
May 2016: Paediatric Anaesthesia
Tatsuma Fukuda, Naoko Ohashi-Fukuda, Takehiro Matsubara, Kent Doi, Yoichi Kitsuta, Susumu Nakajima, Naoki Yahagi
BACKGROUND: Out-of-hospital cardiac arrest (OHCA) has a predominantly non-shockable rhythm. Non-shockable rhythm, and the absence of a bystander witness or bystander cardiopulmonary resuscitation (CPR) are associated with poor outcomes. However, the association between the type of non-shockable rhythm and outcomes is not well known. OBJECTIVE: To examine the association between the initial rhythm and neurologically favorable outcomes after non-shockable OHCA without a bystander witness or bystander CPR...
May 2016: European Journal of Internal Medicine
Joelle Leonie Flueck, Martina Lienert, Fabienne Schaufelberger, Jörg Krebs, Claudio Perret
The aim of our study was to investigate the effect of caffeine supplementation on 3-min all-out arm crank exercise performance in paraplegic (P) and tetraplegic (T) compared with able-bodied (AB) participants. A placebo-controlled, randomized, crossover, and double-blind study design was chosen to investigate the differences between caffeine (CAF) and placebo (PLC). In total, 34 healthy, trained participants were tested. Seventeen were AB (median [minimum; maximum] VO2peak: 33.9 mL/min/kg [23.6; 57.6]), 10 were P (VO2peak: 34...
December 2015: International Journal of Sport Nutrition and Exercise Metabolism
Swati Datta, Sumit Jamwal, Rahul Deshmukh, Puneet Kumar
Tardive Dyskinesia is a severe side effect of chronic neuroleptic treatment consisting of abnormal involuntary movements, characterized by orofacial dyskinesia. The study was designed to investigate the protective effect of lycopene against haloperidol induced orofacial dyskinesia possibly by neurochemical and neuroinflammatory modulation in rats. Rats were administered with haloperidol (1mg/kg, i.p for 21 days) to induce orofacial dyskinesia. Lycopene (5 and 10mg/kg, p.o) was given daily 1hour before haloperidol treatment for 21 days...
January 15, 2016: European Journal of Pharmacology
Farah Syed, Lalit P Chandravanshi, Vinay K Khanna, Inderpal Soni
Beta-cyfluthrin (CYF) is a commonly used synthetic pyrethroid having both agricultural and domestic applications. The present study aimed to evaluate the neurobehavioural effects of beta-cyfluthrin in adult rats administered at doses 25 mg/kg body weight/day and 12.5 mg/kg body weight/day for a period of 30 days. Motor coordination and spatial memory were found to be impaired by beta-cyfluthrin. Levels of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), epinephrine (EPN), and serotonin (5-HT) decreased in frontal cortex, corpus striatum and hippocampus of treated rats...
January 5, 2016: Chemico-biological Interactions
A C Collier, B L M Sato, K A Milam, T E Wright
BACKGROUND: These studies were undertaken to determine methamphetamine (METH) and smoking effects on umbilical vascular dynamics and pregnancy outcomes. MATERIALS AND METHODS: Umbilical cords (54) were collected prospectively at birth, washed of blood, and stored at -80°C. Cords were thawed and lysates prepared, then catecholamine levels quantified with enzyme-linked immunosorbent assay (ELISA). RESULTS: Catecholamine levels in umbilical cords were not associated with maternal or gestational age, gravidity, parity, neonatal or placental weight...
2015: Clinical and Experimental Obstetrics & Gynecology
Yuming Du, Lirui Wang, Huijuan Shi, Min Gao
This study aims to compare the clinical effect of dopamine and nor epinephrine in the treatment of septic shock. Fifty cases with septic shock were randomly divided into two groups. Patients in both two groups revived after taking effective liquid. Then dopamine was pumped into central veins of patients in the research group (group DA) in 2 μ/(kg•min) upon the conventional treatment, while nor epinephrine was pumped into patients in the control group (group NE) in 0.1 μ/(kg•min), besides conventional treatment...
July 2015: Pakistan Journal of Pharmaceutical Sciences
Ian M Gralnek, Jean-Marc Dumonceau, Ernst J Kuipers, Angel Lanas, David S Sanders, Matthew Kurien, Gianluca Rotondano, Tomas Hucl, Mario Dinis-Ribeiro, Riccardo Marmo, Istvan Racz, Alberto Arezzo, Ralf-Thorsten Hoffmann, Gilles Lesur, Roberto de Franchis, Lars Aabakken, Andrew Veitch, Franco Radaelli, Paulo Salgueiro, Ricardo Cardoso, Luís Maia, Angelo Zullo, Livio Cipolletta, Cesare Hassan
This Guideline is an official statement of the European Society of Gastrointestinal Endoscopy (ESGE). It addresses the diagnosis and management of nonvariceal upper gastrointestinal hemorrhage (NVUGIH). Main Recommendations MR1. ESGE recommends immediate assessment of hemodynamic status in patients who present with acute upper gastrointestinal hemorrhage (UGIH), with prompt intravascular volume replacement initially using crystalloid fluids if hemodynamic instability exists (strong recommendation, moderate quality evidence)...
October 2015: Endoscopy
Marie-Cécile Valéra, Coralie Fontaine, Françoise Lenfant, Cendrine Cabou, Maeva Guillaume, Natalia Smirnova, Sung Hoon Kim, Pierre Chambon, John A Katzenellenbogen, Benita S Katzenellenbogen, Bernard Payrastre, Jean-François Arnal
We recently reported that chronic 17β-estradiol (E2) treatment in mice decreases platelet responsiveness, prolongs the tail-bleeding time and protects against acute thromboembolism via the hematopoietic estrogen receptor alpha (ERα), and independently of ERβ. Here, we have explored the respective roles of membrane vs nuclear actions of ERα in this process, using: 1) the selective activator of membrane ERα: estrogen dendrimer conjugate, and 2) mouse models with mutations in ERα. The selective targeting of activation function 2 of ERα provides a model of nuclear ERα loss-of-function, whereas mutation of the ERα palmitoylation site leads to a model of membrane ERα deficiency...
November 2015: Endocrinology
Li-Li Han, Ling Chen, Zhi-Ling Dong
The present investigation aimed to evaluate the acute and chronic effect of stress (stress hormone) in male albino rat brain. Nor-epinephrine was used for the treatment and saline used for the control. Nor-epinephrine was dissolved in the saline and administered orally to the rats. Following nor-epinephrine administration, the brain was removed surgically at 6 h, 12 h and 45 days. Alanine tansaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) were significantly altered in the rats. Lipid peroxidation was measured as malondialdehyde (MDA), showed altered lipid peroxidation...
2015: International Journal of Clinical and Experimental Pathology
Marek A Deja, Aleksandra Żak, Marcin Malinowski, Piotr Pysz, Ewa Gaszewska-Żurek, Maciej Turski, Piotr Janusiewicz, Krystian Wita, Jerzy Chudek
BACKGROUND: Restrictive mitral annuloplasty is the preferred method of treating secondary mitral regurgitation. The use of small annuloplasty rings to reduce the high recurrence rates may result in mitral stenosis. METHODS: Thirty-six patients who underwent restrictive mitral annuloplasty with Carpentier-Edwards classic 26 size ring underwent exercise echocardiography and ergospirometry. Resting catecholamines and N-terminal pro brain natriuretic peptide (NT-proBNP) levels were measured...
October 2015: Annals of Thoracic Surgery
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