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https://www.readbyqxmd.com/read/29629564/thrombin-activatable-fibrinolysis-inhibitor-polymorphisms-and-cerebral-venous-thrombosis-in-mexican-mestizo-patients
#1
Antonio Arauz, Nayelli Argüelles, Aurelio Jara, Jorge Guerrero, Miguel A Barboza
Thrombin-activatable fibrinolysis inhibitor (TAFI) gene polymorphisms have been proposed as a predisposing factor for cerebral venous thrombosis (CVT). We analyzed the association between CVT and TAFI single-nucleotide polymorphisms (rs3742264, rs2146881, and rs1926447) compared to healthy controls. Mexico Mestizo confirmed cases with CVT and age- and sex-matched controls with no history of venous thrombotic events were recruited from July 2006 to July 2015. Demographic, clinical, and imaging information was included in the analysis...
January 1, 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29627811/global-epidemiology-and-patterns-of-cerebral-venous-thrombosis-a-systematic-review-and-meta-analysis-protocol
#2
Celestin Danwang, Temgoua Ngou Mazou, Joël Noutakdie Tochie, Ronni Tankeu, Jean Joel Bigna
INTRODUCTION: Venous thrombosis can affect all veins in the body including cerebral veins, where it causes cerebral venous thrombosis (CVT). CVT is an aetiology of stroke, particularly in children and young adults. Its clinical features vary widely according to the occluded vessel. Data concerning the epidemiology of CVT are scant. This protocol for a systematic review and meta-analysis aims to critically synthesise data concerning prevalence, incidence, risk factors, anatomical patterns, diagnostic and therapeutic delays, and mortality rate of CVT in the global population...
April 7, 2018: BMJ Open
https://www.readbyqxmd.com/read/29609577/handgrip-force-steadiness-in-young-and-older-adults-a-reproducibility-study
#3
Andreas W Blomkvist, Fredrik Eika, Eling D de Bruin, Stig Andersen, Martin Jorgensen
BACKGROUND: Force steadiness is a quantitative measure of the ability to control muscle tonus. It is an independent predictor of functional performance and has shown to correlate well with different degrees of motor impairment following stroke. Despite being clinically relevant, few studies have assessed the validity of measuring force steadiness. The aim of this study was to explore the reproducibility of handgrip force steadiness, and to assess age difference in steadiness. METHOD: Intrarater reproducibility (the degree to which a rating gives consistent result on separate occasions) was investigated in a test-retest design with seven days between sessions...
April 2, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29607518/effects-of-multidimensional-tunneling-in-the-kinetics-of-hydrogen-abstraction-reactions-of-o-3-p-with-ch-3-ocho
#4
E F V de Carvalho, O Roberto-Neto
Quantum tunneling paths are important in reactions when there is a significant component of hydrogenic motion along the potential energy surface. In this study, variational transition state with multidimensional tunneling corrections are employed in the calculations of the thermal rate constants for hydrogen abstraction from the cis-CH3 OCHO by O (3 P) giving CH3 OCO + OH (R1) and CH2 OCHO + OH (R2). The structures and electronic energies are computed with the M06-2X method. Benchmark calculations with the CBSD-T approach give an enthalpy of reaction at 0 K for R1 (-2...
April 1, 2018: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/29600909/spontaneous-occult-intracranial-hypotension-precipitating-life-threatening-cerebral-venous-thrombosis-case-report
#5
Avital Perry, Christopher S Graffeo, Waleed Brinjikji, William R Copeland, Alejandro A Rabinstein, Michael J Link
Spontaneous intracranial hypotension (SIH) is an uncommon headache etiology, typically attributable to an unprovoked occult spinal CSF leak. Although frequently benign, serious complications may occur, including cerebral venous thrombosis (CVT). The objective of this study was to examine a highly complicated case of CVT attributable to SIH as a lens for understanding the heterogeneous literature on this rare complication, and to provide useful, evidence-based, preliminary clinical recommendations. A 43-year-old man presented with 1 week of headache, dizziness, and nausea, which precipitously evolved to hemiplegia...
March 30, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29594079/sudden-bilateral-sensorineural-hearing-loss-secondary-to-cerebral-venous-thrombosis
#6
Muhammad-Nu'aim Ishak, Nik-Mohd-Syukra Nik-Abdul-Ghani, Irfan Mohamad
Introduction: Sudden sensorineural hearing loss (SSNHL) is an important otological emergency. Up to 90% of the cases are idiopathic. Cerebral venous thrombosis (CVT) is an extremely rare identifiable cause as it only represents 0.5% of all strokes. Case Report: In this paper, an unusual case of bilateral SSNHL secondary to bilateral CVT with rapid and complete recovery is reported. The patient presented with sudden bilateral hearing loss associated with some neurological symptoms...
March 2018: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29574222/the-dilemma-of-anticoagulating-patients-with-cerebral-venous-thrombosis-who-underwent-decompressive-craniectomy
#7
Plinio Duarte Mendes, Clayton Lucas da Silva Lopes, Diogo Mendes França, Jarbas Carvalhais Reis, Augusto Cesar de Jesus Santos, Rogerio Zenobio Darwich
BACKGROUND: Cerebral venous thrombosis (CVT) is an uncommon subtype of cerebrovascular accident. The time to be allowed between decompressive craniectomy (DC) and the onset of anticoagulation in patients diagnosed with CVT is still a controversial topic among neurosurgeons, neurologists, and intensivists. CASE DESCRIPTION: We present a brief clinical case report of a female patient who underwent DC and was later diagnosed with CVT, for whom anticoagulation was initiated 24 hours postoperatively...
March 21, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29548522/co-poisoning-as-an-associated-risk-factor-for-cvt-a-case-report
#8
Trevor A Phinney, Grant J Gibb, Fahad J Laghari
We report a 24year old female who presented with sudden and severe headaches after recent carbon monoxide poisoning. Imaging revealed an acute cerebral venous thrombosis. Prior studies have suggested that carbon monoxide is a risk factor for an acute hypercoagulable state (i.e. DVT). However, little data is available regarding the correlation between carbon monoxide poisoning and cerebral venous thrombosis. This case demonstrates that such a correlation should be considered in acute intracerebral thrombotic events...
March 3, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29523353/can-anticoagulation-therapy-in-cerebral-venous-thrombosis-associated-with-beh%C3%A3-et-s-disease-be-stopped-without-relapse
#9
M Roriz, I Crassard, S Lechtman, D Saadoun, K Champion, B Wechsler, H Chabriat, D Sène
There is as yet no consensus on the treatment of cerebral venous thrombosis (CVT) in Behçet's disease, and the place of anticoagulation is also still being debated. This report is of a series of seven patients with Behçet's disease (BD)-associated CVT, for which anticoagulation was stopped, and discusses the possibility of stopping anticoagulation during follow-up while receiving optimal treatment for BD. The diagnosis of BD was established during follow-up, which lasted a median of 120 [range: 60-1490] days after CVT diagnosis...
March 2018: Revue Neurologique
https://www.readbyqxmd.com/read/29499845/anticoagulation-results-in-increased-line-salvage-for-children-with-intestinal-failure-and-central-venous-thrombosis
#10
Cory M McLaughlin, Monica Bennett, Nandini Channabasappa, Janna Journeycake, Hannah G Piper
PURPOSE: The purpose of this study was to investigate whether anticoagulation (AC) results in thrombus resolution and increased line longevity in children with intestinal failure (IF) and catheter-associated central venous thrombosis (CVT). METHODS: A retrospective, single institution review was performed of children with IF who were dependent on parenteral nutrition with known CVT between 2006 and 2017. Frequency of catheter-related complications including infection, occlusion, and breakage were compared 18months prior to and after starting AC...
February 7, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29481444/regional-cerebral-oxygen-saturation-changes-after-decompressive-craniectomy-for-malignant-cerebral-venous-thrombosis-a-prospective-cohort-study
#11
Pavithra Venkateswaran, Kamath Sriganesh, Dhritiman Chakrabarti, Deepti B Srinivas, Ganne S Umamaheswara Rao
BACKGROUND: Decompressive craniectomy (DC) is a life-saving intervention for malignant cerebral venous thrombosis (CVT). Earlier studies have shown increase in cerebral oxygenation after DC in traumatic brain injury but similar studies are lacking in CVT. We hypothesized that regional cerebral (tissue) oxygen saturation (rSO2) on the side of CVT is lower than the contralateral side and improves after DC. MATERIALS AND METHODS: In this prospective cohort study, rSO2 was monitored using near-infrared spectroscopy technique, before and after DC on both cerebral hemispheres...
February 23, 2018: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/29473645/locomotor-activity-growth-hormones-and-systemic-robusticity-an-investigation-of-cranial-vault-thickness-in-mouse-lines-bred-for-high-endurance-running
#12
L E Copes, H Schutz, E M Dlugsoz, S Judex, T Garland
OBJECTIVES: To use a mouse model to investigate the relationships among the components of the systemic robusticity hypothesis (SRH): voluntary exercise on wheels, spontaneous physical activity (SPA) in cages, growth hormones, and skeletal robusticity, especially cranial vault thickness (CVT). MATERIALS AND METHODS: Fifty female mice from lines artificially selected for high running (HR) and 50 from nonselected control (C) lines were housed in cages with (Active) or without wheels (Sedentary)...
February 23, 2018: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/29441008/diagnosis-and-treatment-of-cerebral-venous-thrombosis-a-review
#13
REVIEW
Yaxi Luo, Xin Tian, Xuefeng Wang
Cerebral venous thrombosis (CVT), also called cerebral venous sinus thrombosis (CVST), is a cerebrovascular disease with diverse clinical manifestations that often affects young adults, women of childbearing age, and children. It's most common clinical manifestations are headache, seizures, altered consciousness, and neurological focal signs on physical examination. CVT can manifest as a single symptom, or it can present as a syndrome consisting of multiple symptoms. This non-specific clinical picture makes diagnosing CVT difficult...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29438263/validity-and-acceptance-of-color-vision-testing-on-smartphones
#14
Omar K Ozgur, Trisha S Emborgo, Mark B Vieyra, Rebecca F Huselid, Rudrani Banik
BACKGROUND: Ishihara color plates (ICP) are the most commonly used color vision test (CVT) worldwide. With the advent of new technologies, attempts have been made to streamline the process of CVT. As hardware and software evolve, smartphone-based testing modalities may aid ophthalmologists in performing more efficient ophthalmic examinations. We assess the validity of smartphone color vision testing (CVT) by comparing results using the Eye Handbook (EHB) CVT application with standard Ishihara color plates (ICP)...
March 2018: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/29436443/diagnosis-and-management-of-cerebral-venous-thrombosis
#15
Roya Behrouzi, Martin Punter
Cerebral venous thrombosis (CVT) is rare and accounts for 0.5% of all strokes. Its clinical presentation is variable and diagnosis requires a high index of clinical suspicion in conjunction with neuroradiological diagnostic support. Treatment options are limited and are mostly based on consensus. Therefore, familiarity with international guidelines is important. Outcome is often good and most patients make a full recovery, although a small proportion suffers death or disability. Here, we describe the clinical features, risk factors, acute imaging features, management and complications of CVT...
February 2018: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/29402471/direct-oral-anticoagulant-use-in-patients-with-thrombophilia-antiphospholipid-syndrome-or-venous-thrombosis-of-unusual-sites-a-narrative-review
#16
REVIEW
Laurent Bertoletti, Ygal Benhamou, Yannick Béjot, Sylvestre Marechaux, Saida Cheggour, Boris Aleil, Nicolas Lellouche, Jean-Guillaume Dillinger, Aurélien Delluc
Direct oral anticoagulants (DOACs) are indicated in the treatment and prevention of venous thromboembolism (VTE). However, the use of DOACs in unusual VTE, including cerebral venous thrombosis (CVT) and splanchnic venous thrombosis (SVT), and in patients with biological thrombophilia including minor thrombophilia (Factor V Leiden and prothrombin G20210A), major innate thrombophilia (protein C and S deficiency, and antithrombin) and major acquired thrombophilia (antiphospholipid syndrome [APS]), remains controversial due to the paucity of available data...
February 2, 2018: Blood Reviews
https://www.readbyqxmd.com/read/29390539/oral-contraceptives-caused-venous-sinus-thrombosis-complicated-with-cerebral-artery-infarction-and-secondary-epileptic-seizures-a-case-report-and-literature-review
#17
Feng Xu, Cuifang Liu, Xiaobo Huang
RATIONALE: Venous sinus thrombosis is a special type of cerebrovascular disease. Its incidence is low and its symptoms are lack of specificity. And its early diagnosis and treatment are very difficult. PATIENT CONCERNS: This paper reported a rare case of a 43-year-old female who presented with cerebral venous thrombosis (CVT) complicated with cerebral artery infarction and secondary epileptic seizures due to oral contraceptives. DIAGNOSES: The final diagnosis was intracranial venous sinus thrombosis, acute cerebral infarction in the left parietal lobe, intracranial hypertension syndrome, and continuous epilepsy...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29388927/-the-comparative-analysis-of-the-influence-of-the-supervised-exercise-training-and-home-based-exercise-training-on-the-psychological-status-of-the-following-coronary-artery-bypass-grafting
#18
S A Pomeshkina, E B Loktionova, V A Bezzubova, N V Arkhipova, I М Borovik, O L Barbarash
This article was designed to report the results of the comparative analysis of the influence of the home-based exercise training (HBT) and the supervised exercise training in the form of the controlled training (CVT) under conditions of outpatient rehabilitative treatment on the patients' quality of life (QoL) and psychological status (including manifestations of anxiety and depression) following coronary artery bypass grafting (CABG). AIM: The objective of the present study was to evaluate the consequences of the application of different programs of physical rehabilitation under the outpatient conditions on the psychoemotional status and quality of life of the patients who had undergone coronary artery bypass grafting...
December 28, 2017: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/29370521/interpolative-separable-density-fitting-through-centroidal-voronoi-tessellation-with-applications-to-hybrid-functional-electronic-structure-calculations
#19
Kun Dong, Wei Hu, Lin Lin
The recently developed interpolative separable density fitting (ISDF) decomposition is a powerful way for compressing the redundant information in the set of orbital pairs, and has been used to accelerate quantum chemistry calculations in a number of contexts. The key ingredient of the ISDF decomposition is to select a set of non-uniform grid points, so that the values of the orbital pairs evaluated at such grid points can be used to accurately interpolate those evaluated at all grid points. The set of non-uniform grid points, called the interpolation points, can be automatically selected by a QR factorization with column pivoting (QRCP) procedure...
January 25, 2018: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29367996/catalytic-effect-of-a-single-water-molecule-on-the-oh-ch2nh-reaction
#20
Mohamad Akbar Ali, Balaganesh M, K C Lin
In recent work, there has been considerable speculation about the atmospheric reaction of methylenimine (CH2NH), because this compound is highly reactive, soluble in water, and sticky, thus posing severe experimental challenges. In this work, we have revisited the kinetics of the OH + CH2NH reaction assisted by a single water molecule. The potential energy surfaces (PESs) for the water-assisted OH + CH2NH reaction were calculated using the CCSD(T)//BH&HLYP/aug-cc-pVTZ levels of theory. The rate coefficients for the bimolecular reaction pathways CH2NHH2O + OH and CH2NH + H2OHO were computed using canonical variational transition state theory (CVT) with small curvature tunneling correction...
January 25, 2018: Physical Chemistry Chemical Physics: PCCP
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