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Xueli Bai

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https://www.readbyqxmd.com/read/28705232/hypoxia-inducible-factor-2%C3%AE-promotes-tumor-progression-and-has-crosstalk-with-wnt-%C3%AE-catenin-signaling-in-pancreatic-cancer
#1
Qi Zhang, Yu Lou, Jingying Zhang, Qihan Fu, Tao Wei, Xu Sun, Qi Chen, Jiaqi Yang, Xueli Bai, Tingbo Liang
BACKGROUND: Pancreatic cancer is a devastating disease that is characterized by persistent hypoxia. The roles of hypoxia-inducible factor-2α (hif-2α) are different to those of hif-1α, although both are critical for tumor cells to adapt to the hypoxic microenvironment. However, unlike the well-studied hif-1α, the role of hif-2α in tumors, including pancreatic cancer, is poorly understood. METHODS: Herein, we used a mutated hif-2α (A530T) to figure out the problem that wild-type hif-2α is quickly degraded which limits the study of its function...
July 14, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28590550/osi-027-modulates-acute-graft-versus-host-disease-after-liver-transplantation-in-a-rat-model
#2
Xiao Zhi, Fei Xue, Wei Chen, Chao Liang, Hao Liu, Tao Ma, Xuefeng Xia, Liqiang Hu, Xueli Bai, Tingbo Liang
Despite its rarity (1%-2%), acute graft-versus-host disease after liver transplantation (LT-aGVHD) has a high mortality rate (85%). A gradual decrease in regulatory T cells (Tregs) correlates with disease progression in a rat LT-GVHD model, and treatments which increase Tregs exert therapeutic effects on LT-aGVHD. In this study, LT-aGVHD model rats were treated with rapamycin (RAPA), OSI-027, or an equal quantity of vehicle. Rats treated with OSI-027 survived longer (>100 days) than those in the RAPA (70 ± 8 days) or control (24 ± 3 days) groups...
September 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28223311/single-tumor-initiating-cells-evade-immune-clearance-by-recruiting-type-ii-macrophages
#3
Xiaocan Guo, Yang Zhao, Huan Yan, Yingcheng Yang, Shuying Shen, Xiaoming Dai, Xinyan Ji, Fubo Ji, Xing-Guo Gong, Li Li, Xueli Bai, Xin-Hua Feng, Tingbo Liang, Junfang Ji, Lei Chen, Hongyang Wang, Bin Zhao
Tumor infiltrated type II (M2) macrophages promote tumorigenesis by suppressing immune clearance, promoting proliferation, and stimulating angiogenesis. Interestingly, macrophages were also found to enrich in small foci of altered hepatocytes containing liver tumor-initiating cells (TICs). However, whether and how TICs specifically recruit macrophages and the function of these macrophages in tumor initiation remain unknown due to technical difficulties. In this study, by generating genetically defined liver TICs, we demonstrate that TICs actively recruit M2 macrophages from as early as the single-cell stage...
February 1, 2017: Genes & Development
https://www.readbyqxmd.com/read/28098749/a-semipersistent-plant-virus-differentially-manipulates-feeding-behaviors-of-different-sexes-and-biotypes-of-its-whitefly-vector
#4
Shaohua Lu, Jingjing Li, Xueli Wang, Danyang Song, Rune Bai, Yan Shi, Qinsheng Gu, Yen-Wen Kuo, Bryce W Falk, Fengming Yan
It is known that plant viruses can change the performance of their vectors. However, there have been no reports on whether or how a semipersistent plant virus manipulates the feeding behaviors of its whitefly vectors. Cucurbit chlorotic yellows virus (CCYV) (genus Crinivirus, family Closteroviridae) is an emergent plant virus in many Asian countries and is transmitted specifically by B and Q biotypes of tobacco whitefly, Bemisia tabaci (Gennadius), in a semipersistent manner. In the present study, we used electrical penetration graph (EPG) technique to investigate the effect of CCYV on the feeding behaviors of B...
January 13, 2017: Viruses
https://www.readbyqxmd.com/read/27992496/field-sandbur-cenchrus-pauciflorus-seeds-in-the-same-bur-respond-differently-to-temperature-and-water-potential-in-relation-to-germination-in-a-semi-arid-environment-china
#5
Zhixin Zhang, Xun Tian, Yuguang Bai, Huifang Liu, Xueli Niu, Zhiwei Wang, Qian Wang
The success of a biological invasion relies on the environment and is closely linked to factors such as water and temperature. Invasive plant species display different seed characteristics, including shape. Field sandbur (Cenchrus pauciflorus) is a globally widespread invasive species capable of adapting to broad environmental conditions. However, its germination response to water and temperature still remains unclear. C. pauciflorus contains two seeds in the same bur that differ in size: big seeds (M) and small seeds (P)...
2016: PloS One
https://www.readbyqxmd.com/read/27826046/meta-analysis-of-invagination-and-duct-to-mucosa-pancreaticojejunostomy-after-pancreaticoduodenectomy-an-update
#6
REVIEW
Xu Sun, Qi Zhang, JingYing Zhang, Yu Lou, QiHan Fu, XingLong Zhang, TingBo Liang, XueLi Bai
OBJECTIVE: Duct-to-mucosa and invagination are two commonly used techniques of pancreaticojejunostomy (PJ) after pancreaticoduodenectomy. Previously, we conducted a systematic review comparing the safety and efficacy of the two PJ techniques. Here, we added new evidence and updated our previous conclusion. METHODS: We systematically searched multiple databases and included randomized controlled trials (RCTs) comparing duct-to-mucosa and invagination techniques of PJ...
December 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27756417/pancreatic-cancer-adjuvant-radiotherapy-target-volume-design-based-on-the-postoperative-local-recurrence-spatial-location
#7
Wei Yu, Wei Hu, Yongjie Shui, Xiaoyang Zhu, Chao Li, Xiaoqiu Ren, Xueli Bai, Risheng Yu, Li Shen, Tingbo Liang, Lei Zheng, Qichun Wei
OBJECTIVES: To explore the areas at highest risk for postoperative pancreatic cancer local recurrence according to the spatial location of local failures, with the aim to provide a precise target volume for pancreatic cancer adjuvant radiotherapy. METHODS: Patients with pancreatic cancer who had undergone surgery for the primary tumor in pancreas at our institution from January 2010 to August 2015 were retrospectively analyzed. All local recurrences were plotted on the computed tomography (CT) image of a representative patient according to their relative coordinates to superior mesenteric artery (SMA) or celiac axis (CA)...
October 19, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27594673/g-protein-coupled-estrogen-receptor-deficiency-accelerates-liver-tumorigenesis-by-enhancing-inflammation-and-fibrosis
#8
Tao Wei, Wei Chen, Liang Wen, Jian Zhang, Qi Zhang, Jiaqi Yang, Hao Liu, Bryan Wei Chen, Yue Zhou, Xinhua Feng, Qi Yang, Xueli Bai, Tingbo Liang
G protein-coupled estrogen receptor (GPER) is a novel estrogen-binding receptor involved in many pathological conditions, including cancer. In this study, we investigated the effect of GPER on hepatocellular carcinoma (HCC). Our data show GPER knockout in a diethylnitrosamine (DEN)-induced mouse tumor model significantly accelerated liver tumorigenesis, accompanied by enhanced immune cell infiltration, fibrosis, and the production of inflammatory factors, such as interleukin-6 (IL-6). We further delineated the function of GPER in macrophages and hepatic stellate cells (HSCs)...
November 28, 2016: Cancer Letters
https://www.readbyqxmd.com/read/27463713/anti-diabetic-effect-of-portulaca-oleracea-l-polysaccharideandits-mechanism-in-diabetic-rats
#9
Yu Bai, Xueli Zang, Jinshu Ma, Guangyu Xu
Diabetes mellitus (DM) is a metabolic syndrome caused by multiple genetic and environmental factors. Traditional Chinese medicine preparations have shown a comprehensive and function-regulating characteristic. Purslane (Portulaca oleracea L.) is an annual succulent herb. Currently, there have been some related reports on the treatment of diabetes with purslane. The current study was designed to separate and purify the polysaccharide, a systematic study of its physical and chemical properties, antioxidant activity, and anti-diabetic mechanism, in order to provide a theoretical basis for the development of drugs of purslane...
July 25, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27339327/the-hepatitis-b-virus-x-protein-promotes-pancreatic-cancer-through-modulation-of-the-pi3k-akt-signaling-pathway
#10
Yiwen Chen, Xueli Bai, Qi Zhang, Liang Wen, Wei Su, Qihan Fu, Xu Sun, Yu Lou, Jiaqi Yang, Jingying Zhang, Qi Chen, Jianxin Wang, Tingbo Liang
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and lethal cancer, with poor outcomes. Infection with the hepatitis B virus (HBV) may be associated as a worse prognosis for PDAC patients; however, the mechanisms involved in this process are unclear. We evaluated whether HBV infection leads to PDAC with a more aggressive phenotype, and attempted to elucidate the mechanisms involved. Clinicopathological data and outcomes from 64 patients with PDAC were collected and compared between serum HBsAg+ and HBsAg- patients...
September 28, 2016: Cancer Letters
https://www.readbyqxmd.com/read/27126361/ark5-promotes-doxorubicin-resistance-in-hepatocellular-carcinoma-via-epithelial-mesenchymal-transition
#11
Tao Xu, Jian Zhang, Wei Chen, Shengjing Pan, Xiao Zhi, Liang Wen, Yue Zhou, Bryan Wei Chen, Junyu Qiu, Yun Zhang, Qi Yang, Xinhua Feng, Xueli Bai, Tingbo Liang
AMP-activated protein kinase family member 5 (ARK5) overexpression has been reported in many human cancers, and ARK5 is associated with poor prognosis in hepatocellular carcinoma (HCC). However, whether ARK5 is involved in HCC chemoresistance is unclear. The present study aimed to investigate the role of ARK5 in HCC chemoresistance and the underlying mechanism. In this study, we found that SNU387 and SNU449 HCC cell lines overexpressing ARK5 displayed low doxorubicin sensitivity compared to Huh7 and Hep3B HCC cell lines with ARK5 low-expression...
July 28, 2016: Cancer Letters
https://www.readbyqxmd.com/read/27090583/the-implementation-of-an-enhanced-recovery-after-surgery-eras-program-following-pancreatic-surgery-in-an-academic-medical-center-of-china
#12
Xueli Bai, Xiaoyu Zhang, Fangyan Lu, Guogang Li, Shunliang Gao, Jianying Lou, Yun Zhang, Tao Ma, Ji Wang, Wei Chen, Bingfeng Huang, Tingbo Liang
INTRODUCTION: The experience of implementing enhanced recovery after surgery (ERAS) programs in pancreatic surgery is limited. The aim of this study was to evaluate the feasibility of ERAS program in pancreatic surgery in an academic medical center of China. METHODS: Between May 2014 and August 2015, 124 patients managed with an ERAS program following pancreatic surgery (ERAS group), were compared to a historical cohort of 63 patients, treated with traditional perioperative care between August 2013 and April 2014 (no-ERAS group)...
July 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/27011063/regulation-of-multi-drug-resistance-in-hepatocellular-carcinoma-cells-is-trpc6-calcium-dependent
#13
Liang Wen, Chao Liang, Enjiang Chen, Wei Chen, Feng Liang, Xiao Zhi, Tao Wei, Fei Xue, Guogang Li, Qi Yang, Weihua Gong, Xinhua Feng, Xueli Bai, Tingbo Liang
Hepatocellular carcinoma (HCC) is notoriously refractory to chemotherapy because of its tendency to develop multi-drug resistance (MDR), whose various underlying mechanisms make it difficult to target. The calcium signalling pathway is associated with many cellular biological activities, and is also a critical player in cancer. However, its role in modulating tumour MDR remains unclear. In this study, stimulation by doxorubicin, hypoxia and ionizing radiation was used to induce MDR in HCC cells. A sustained aggregation of intracellular calcium was observed upon these stimuli, while inhibition of calcium signalling enhanced the cells' sensitivity to various drugs by attenuating epithelial-mesenchymal transition (EMT), Hif1-α signalling and DNA damage repair...
March 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/26922601/roles-of-sphincter-of-oddi-laxity-in-bile-duct-microenvironment-in-patients-with-cholangiolithiasis-from-the-perspective-of-the-microbiome-and-metabolome
#14
Tingbo Liang, Wei Su, Qi Zhang, Guogang Li, Shunliang Gao, Jianying Lou, Yun Zhang, Tao Ma, Xueli Bai
BACKGROUND: Bile duct microenvironment plays several key roles in cholangiolithiasis occurrence. Sphincter of Oddi laxity (SOL) is associated with cholangiolithiasis, probably due to enhanced reflux of intestinal contents that changes the microenvironment. However, the microenvironment has not been investigated comprehensively. STUDY DESIGN: Patients with cholangiolithiasis were consecutively recruited and their bile was collected intraoperatively for high-throughput experiments...
March 2016: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/26883344/ursolic-acid-loaded-chitosan-nanoparticles-induce-potent-anti-angiogenesis-in-tumor
#15
Hua Jin, Jiang Pi, Fen Yang, Chaomin Wu, Xueli Cheng, Haihua Bai, Dan Huang, Jinhuan Jiang, Jiye Cai, Zheng W Chen
Angiogenesis provides necessary nutrients and oxygen for tumor growth and metastasis; thus, every stage of angiogenesis process is the potential target for cancer therapies. Ursolic acid (UA) is reported to decrease tumor burden through anti-angiogenesis pathway, but its poor water solubility greatly limits its efficiency and clinical application. Here, a simple method for preparing UA-loaded chitosan nanoparticles (CH-UA-NPs) with anti-angiogenesis and anti-tumor activity was demonstrated. In vitro, CH-UA-NPs could significantly inhibit the proliferation, migration, and tube formation of human umbilical vascular endothelial cells (HUVECs)...
August 2016: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/26788137/expression-of-b-cell-specific-moloney-murine-leukemia-virus-integration-site-1-in-vulvar-squamous-cell-carcinoma-and-its-effect-on-the-biological-behavior-of-a-431-cells
#16
Xueli Bai, Ling Ouyang, B O Li, Yang Zhou, Xin Wen
The aim of the present study was to investigate the expression of B cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) in vulvar squamous cell carcinoma (VSCC) and vulvar intraepithelial neoplasia (VIN). Furthermore, the present study investigated the effects of BMI-1 expression on the biological behavior of A-431 human epidermoid carcinoma cells. BMI-1 expression in human VSCC and VIN tissues was detected using immunohistochemistry. Subsequently, BMI-1 expression was silenced in A-431 cells using small interfering RNA (siRNA), and BMI-1 expression was detected using reverse transcription-quantitative polymerase chain reaction and western blotting...
December 2015: Oncology Letters
https://www.readbyqxmd.com/read/26718360/one-stage-laproendoscopic-procedure-versus-two-stage-procedure-in-the-management-for-gallstone-disease-and-biliary-duct-calculi-a-systemic-review-and-meta-analysis
#17
REVIEW
Pankaj Prasson, Xueli Bai, Qi Zhang, Tingbo Liang
BACKGROUND: Laparoscopic common bile duct exploration and endoscopic retrograde cholangiopancreatography (ERCP) are secure and effective techniques that recently been used to treat bile duct stones. The purpose of this research was to assess the intra-procedural efficacy and postprocedural upshots of the laparoscopic common bile duct exploration plus laparoscopic cholecystectomy (LCBDE) and ERCP plus laparoscopic cholecystectomy (ERCP + LC). METHODS: All studies contrasting one-stage (LCBDE) with two-stage (ERCP/EST + LC) managements in patients with concomitant gallstones and common bile duct (CBD) stones were included...
August 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/26577499/duct-to-mucosa-vs-invagination-for-pancreaticojejunostomy-after-pancreaticoduodenectomy-a-prospective-randomized-controlled-trial-from-a-single-surgeon
#18
RANDOMIZED CONTROLLED TRIAL
Xueli Bai, Qi Zhang, Shunliang Gao, Jianying Lou, Guogang Li, Yun Zhang, Tao Ma, Yibo Zhang, Yuanliang Xu, Tingbo Liang
BACKGROUND: Pancreatic fistula (PF) is the most common significant complication after pancreaticoduodenectomy. Invagination and duct-to-mucosa anastomoses are anastomotic techniques that are commonly performed after pancreaticoduodenectomy. There are conflicting data on invagination vs duct-to-mucosa anastomoses about which is superior for minimizing the risk of PF. In addition, all previous studies involved multiple operating surgeons and failed to control for variation in surgeon expertise...
January 2016: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/26396475/a-case-report-on-successful-liver-transplantation-from-a-donor-with-polycystic-liver
#19
Xueli Bai, Longyun Ye, Wei Chen, Chunhui Cao, Liang Wang, Jiangtao Li, Shunliang Gao, Jianying Lou, Yun Zhang, Tingbo Liang
Organ shortage is a major issue faced by both transplant surgeons and patients. To enlarge the donor pool, marginal liver grafts are being increasingly used. In this paper, we present the case of a patient in whom a polycystic liver was successfully transplanted from a donor after brain and cardiac death. To our knowledge, this is the first successful case of liver transplantation using polycystic liver from a donation after brain and cardiac death.
October 2014: Indian Journal of Surgery
https://www.readbyqxmd.com/read/26329277/characteristics-of-tumor-infiltrating-lymphocyte-and-circulating-lymphocyte-repertoires-in-pancreatic-cancer-by-the-sequencing-of-t-cell-receptors
#20
Xueli Bai, Qi Zhang, Song Wu, Xiaoyu Zhang, Mingbang Wang, Fusheng He, Tao Wei, Jiaqi Yang, Yu Lou, Zhiming Cai, Tingbo Liang
Pancreatic cancer has a poor prognosis and few effective treatments. The failure of treatment is partially due to the high heterogeneity of cancer cells within the tumor. T cells target and kill cancer cells by the specific recognition of cancer-associated antigens. In this study, T cells from primary tumor and blood of sixteen patients with pancreatic cancer were characterized by deep sequencing. T cells from blood of another eight healthy volunteers were also studied as controls. By analyzing the complementary determining region 3 (CDR3) gene sequence, we found no significant differences in the T cell receptor (TCR) repertoires between patients and healthy controls...
2015: Scientific Reports
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