keyword
MENU ▼
Read by QxMD icon Read
search

Tingbo Liang

keyword
https://www.readbyqxmd.com/read/28705232/hypoxia-inducible-factor-2%C3%AE-promotes-tumor-progression-and-has-crosstalk-with-wnt-%C3%AE-catenin-signaling-in-pancreatic-cancer
#1
Qi Zhang, Yu Lou, Jingying Zhang, Qihan Fu, Tao Wei, Xu Sun, Qi Chen, Jiaqi Yang, Xueli Bai, Tingbo Liang
BACKGROUND: Pancreatic cancer is a devastating disease that is characterized by persistent hypoxia. The roles of hypoxia-inducible factor-2α (hif-2α) are different to those of hif-1α, although both are critical for tumor cells to adapt to the hypoxic microenvironment. However, unlike the well-studied hif-1α, the role of hif-2α in tumors, including pancreatic cancer, is poorly understood. METHODS: Herein, we used a mutated hif-2α (A530T) to figure out the problem that wild-type hif-2α is quickly degraded which limits the study of its function...
July 14, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28639410/long-term-survival-benefit-of-upfront-chemotherapy-in-patients-with-newly-diagnosed-borderline-resectable-pancreatic-cancer
#2
Bikram Shrestha, Yifei Sun, Farzana Faisal, Victoria Kim, Kevin Soares, Alex Blair, Joseph M Herman, Amol Narang, Avani S Dholakia, Lauren Rosati, Amy Hacker-Prietz, Linda Chen, Daniel A Laheru, Ana De Jesus-Acosta, Dung T Le, Ross Donehower, Nilofar Azad, Luis A Diaz, Adrian Murphy, Valerie Lee, Elliot K Fishman, Ralph H Hruban, Tingbo Liang, John L Cameron, Martin Makary, Matthew J Weiss, Nita Ahuja, Jin He, Christopher L Wolfgang, Chiung-Yu Huang, Lei Zheng
The use of neoadjuvant chemotherapy or radiation for borderline resectable pancreatic adenocarcinoma (BL-PDAC) is increasing. However, the impact of neoadjuvant chemotherapy and radiation therapy on the outcome of BL-PDAC remains to be elucidated. We performed a retrospective analysis of 93 consecutive patients who were diagnosed with BL-PDAC and primarily followed at Johns Hopkins Hospital between February 2007 and December 2012. Among 93 patients, 62% received upfront neoadjuvant chemotherapy followed by chemoradiation, whereas 20% received neoadjuvant chemoradiation alone and 15% neoadjuvant chemotherapy alone...
July 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28590550/osi-027-modulates-acute-graft-versus-host-disease-after-liver-transplantation-in-a-rat-model
#3
Xiao Zhi, Fei Xue, Wei Chen, Chao Liang, Hao Liu, Tao Ma, Xuefeng Xia, Liqiang Hu, Xueli Bai, Tingbo Liang
Despite its rarity (1%-2%), acute graft-versus-host disease after liver transplantation (LT-aGVHD) has a high mortality rate (85%). A gradual decrease in regulatory T cells (Tregs) correlates with disease progression in a rat LT-GVHD model, and treatments which increase Tregs exert therapeutic effects on LT-aGVHD. In this study, LT-aGVHD model rats were treated with rapamycin (RAPA), OSI-027, or an equal quantity of vehicle. Rats treated with OSI-027 survived longer (>100 days) than those in the RAPA (70 ± 8 days) or control (24 ± 3 days) groups...
September 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28223311/single-tumor-initiating-cells-evade-immune-clearance-by-recruiting-type-ii-macrophages
#4
Xiaocan Guo, Yang Zhao, Huan Yan, Yingcheng Yang, Shuying Shen, Xiaoming Dai, Xinyan Ji, Fubo Ji, Xing-Guo Gong, Li Li, Xueli Bai, Xin-Hua Feng, Tingbo Liang, Junfang Ji, Lei Chen, Hongyang Wang, Bin Zhao
Tumor infiltrated type II (M2) macrophages promote tumorigenesis by suppressing immune clearance, promoting proliferation, and stimulating angiogenesis. Interestingly, macrophages were also found to enrich in small foci of altered hepatocytes containing liver tumor-initiating cells (TICs). However, whether and how TICs specifically recruit macrophages and the function of these macrophages in tumor initiation remain unknown due to technical difficulties. In this study, by generating genetically defined liver TICs, we demonstrate that TICs actively recruit M2 macrophages from as early as the single-cell stage...
February 1, 2017: Genes & Development
https://www.readbyqxmd.com/read/28115527/cutting-edge-notch-signaling-promotes-the-plasticity-of-group-2-innate-lymphoid-cells
#5
Kangning Zhang, Xingyuan Xu, Muhammad Asghar Pasha, Christian W Siebel, Angelica Costello, Angela Haczku, Katherine MacNamara, Tingbo Liang, Jinfang Zhu, Avinash Bhandoola, Ivan Maillard, Qi Yang
The mechanisms underlying lymphocyte lineage stability and plasticity remain elusive. Recent work indicates that innate lymphoid cells (ILC) possess substantial plasticity. Whereas natural ILC2 (nILC2) produce type-2 cytokines, plastic inflammatory ILC2 (iILC2) can coproduce both type-2 cytokines and the ILC3-characteristic cytokine, IL-17. Mechanisms that elicit this lineage plasticity, and the importance in health and disease, remain unclear. In this study we show that iILC2 are potent inducers of airway inflammation in response to acute house dust mite challenge...
March 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27826046/meta-analysis-of-invagination-and-duct-to-mucosa-pancreaticojejunostomy-after-pancreaticoduodenectomy-an-update
#6
REVIEW
Xu Sun, Qi Zhang, JingYing Zhang, Yu Lou, QiHan Fu, XingLong Zhang, TingBo Liang, XueLi Bai
OBJECTIVE: Duct-to-mucosa and invagination are two commonly used techniques of pancreaticojejunostomy (PJ) after pancreaticoduodenectomy. Previously, we conducted a systematic review comparing the safety and efficacy of the two PJ techniques. Here, we added new evidence and updated our previous conclusion. METHODS: We systematically searched multiple databases and included randomized controlled trials (RCTs) comparing duct-to-mucosa and invagination techniques of PJ...
December 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27756417/pancreatic-cancer-adjuvant-radiotherapy-target-volume-design-based-on-the-postoperative-local-recurrence-spatial-location
#7
Wei Yu, Wei Hu, Yongjie Shui, Xiaoyang Zhu, Chao Li, Xiaoqiu Ren, Xueli Bai, Risheng Yu, Li Shen, Tingbo Liang, Lei Zheng, Qichun Wei
OBJECTIVES: To explore the areas at highest risk for postoperative pancreatic cancer local recurrence according to the spatial location of local failures, with the aim to provide a precise target volume for pancreatic cancer adjuvant radiotherapy. METHODS: Patients with pancreatic cancer who had undergone surgery for the primary tumor in pancreas at our institution from January 2010 to August 2015 were retrospectively analyzed. All local recurrences were plotted on the computed tomography (CT) image of a representative patient according to their relative coordinates to superior mesenteric artery (SMA) or celiac axis (CA)...
October 19, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27594673/g-protein-coupled-estrogen-receptor-deficiency-accelerates-liver-tumorigenesis-by-enhancing-inflammation-and-fibrosis
#8
Tao Wei, Wei Chen, Liang Wen, Jian Zhang, Qi Zhang, Jiaqi Yang, Hao Liu, Bryan Wei Chen, Yue Zhou, Xinhua Feng, Qi Yang, Xueli Bai, Tingbo Liang
G protein-coupled estrogen receptor (GPER) is a novel estrogen-binding receptor involved in many pathological conditions, including cancer. In this study, we investigated the effect of GPER on hepatocellular carcinoma (HCC). Our data show GPER knockout in a diethylnitrosamine (DEN)-induced mouse tumor model significantly accelerated liver tumorigenesis, accompanied by enhanced immune cell infiltration, fibrosis, and the production of inflammatory factors, such as interleukin-6 (IL-6). We further delineated the function of GPER in macrophages and hepatic stellate cells (HSCs)...
November 28, 2016: Cancer Letters
https://www.readbyqxmd.com/read/27459325/a-redox-sensitive-oligopeptide-guided-self-assembling-and-efficiency-enhanced-rose-system-for-functional-delivery-of-microrna-therapeutics-for-treatment-of-hepatocellular-carcinoma
#9
Qida Hu, Kai Wang, Xu Sun, Yang Li, Qihan Fu, Tingbo Liang, Guping Tang
Lack of efficient adjuvant therapy contributes to a high incidence of recurrence and metastasis of hepatocellular carcinoma (HCC). A novel therapeutic is required for adjuvant treatment of HCC. We developed a polymer-based nanosystem (ROSE) for functional gene therapy by synthesizing a supramolecular complex self-assembled from polycations and functional adamantyl modules. The ROSE system condensing tumor suppressor microRNA-34a (miR-34a) therapeutics becomes ROSE/miR-34a nanoparticles that could facilitate gene transfection in HCC cells with satisfied stability and efficiency, possibly due to proton sponge effect by polycations, PEGlyation protection, and controlled release by breakdown of disulfide bonds...
October 2016: Biomaterials
https://www.readbyqxmd.com/read/27339327/the-hepatitis-b-virus-x-protein-promotes-pancreatic-cancer-through-modulation-of-the-pi3k-akt-signaling-pathway
#10
Yiwen Chen, Xueli Bai, Qi Zhang, Liang Wen, Wei Su, Qihan Fu, Xu Sun, Yu Lou, Jiaqi Yang, Jingying Zhang, Qi Chen, Jianxin Wang, Tingbo Liang
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and lethal cancer, with poor outcomes. Infection with the hepatitis B virus (HBV) may be associated as a worse prognosis for PDAC patients; however, the mechanisms involved in this process are unclear. We evaluated whether HBV infection leads to PDAC with a more aggressive phenotype, and attempted to elucidate the mechanisms involved. Clinicopathological data and outcomes from 64 patients with PDAC were collected and compared between serum HBsAg+ and HBsAg- patients...
September 28, 2016: Cancer Letters
https://www.readbyqxmd.com/read/27126361/ark5-promotes-doxorubicin-resistance-in-hepatocellular-carcinoma-via-epithelial-mesenchymal-transition
#11
Tao Xu, Jian Zhang, Wei Chen, Shengjing Pan, Xiao Zhi, Liang Wen, Yue Zhou, Bryan Wei Chen, Junyu Qiu, Yun Zhang, Qi Yang, Xinhua Feng, Xueli Bai, Tingbo Liang
AMP-activated protein kinase family member 5 (ARK5) overexpression has been reported in many human cancers, and ARK5 is associated with poor prognosis in hepatocellular carcinoma (HCC). However, whether ARK5 is involved in HCC chemoresistance is unclear. The present study aimed to investigate the role of ARK5 in HCC chemoresistance and the underlying mechanism. In this study, we found that SNU387 and SNU449 HCC cell lines overexpressing ARK5 displayed low doxorubicin sensitivity compared to Huh7 and Hep3B HCC cell lines with ARK5 low-expression...
July 28, 2016: Cancer Letters
https://www.readbyqxmd.com/read/27090583/the-implementation-of-an-enhanced-recovery-after-surgery-eras-program-following-pancreatic-surgery-in-an-academic-medical-center-of-china
#12
Xueli Bai, Xiaoyu Zhang, Fangyan Lu, Guogang Li, Shunliang Gao, Jianying Lou, Yun Zhang, Tao Ma, Ji Wang, Wei Chen, Bingfeng Huang, Tingbo Liang
INTRODUCTION: The experience of implementing enhanced recovery after surgery (ERAS) programs in pancreatic surgery is limited. The aim of this study was to evaluate the feasibility of ERAS program in pancreatic surgery in an academic medical center of China. METHODS: Between May 2014 and August 2015, 124 patients managed with an ERAS program following pancreatic surgery (ERAS group), were compared to a historical cohort of 63 patients, treated with traditional perioperative care between August 2013 and April 2014 (no-ERAS group)...
July 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/27011063/regulation-of-multi-drug-resistance-in-hepatocellular-carcinoma-cells-is-trpc6-calcium-dependent
#13
Liang Wen, Chao Liang, Enjiang Chen, Wei Chen, Feng Liang, Xiao Zhi, Tao Wei, Fei Xue, Guogang Li, Qi Yang, Weihua Gong, Xinhua Feng, Xueli Bai, Tingbo Liang
Hepatocellular carcinoma (HCC) is notoriously refractory to chemotherapy because of its tendency to develop multi-drug resistance (MDR), whose various underlying mechanisms make it difficult to target. The calcium signalling pathway is associated with many cellular biological activities, and is also a critical player in cancer. However, its role in modulating tumour MDR remains unclear. In this study, stimulation by doxorubicin, hypoxia and ionizing radiation was used to induce MDR in HCC cells. A sustained aggregation of intracellular calcium was observed upon these stimuli, while inhibition of calcium signalling enhanced the cells' sensitivity to various drugs by attenuating epithelial-mesenchymal transition (EMT), Hif1-α signalling and DNA damage repair...
March 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27007054/interplay-between-myeloid-derived-suppressor-cells-mdscs-and-th17-cells-foe-or-friend
#14
REVIEW
Liang Wen, Ping Gong, Chao Liang, Dawei Shou, Baoqing Liu, Yiwen Chen, Changqian Bao, Li Chen, Xiaowei Liu, Tingbo Liang, Weihua Gong
Myeloid-derived suppressor cells (MDSCs) and Th17 cells were first discovered in the fields of cancer and autoimmunity, respectively. In recent years, their activities have been explored in other biological and pathological conditions, such as infective diseases and solid organ transplantation. However, the interplay between MDSCs and Th17 cells and the mechanism of their interaction remain obscure. This review summarized and analyzed the relationship between MDSCs and Th17 cells, both of which participate in tumor, autoimmune disease, infection and other conditions...
June 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/26922601/roles-of-sphincter-of-oddi-laxity-in-bile-duct-microenvironment-in-patients-with-cholangiolithiasis-from-the-perspective-of-the-microbiome-and-metabolome
#15
Tingbo Liang, Wei Su, Qi Zhang, Guogang Li, Shunliang Gao, Jianying Lou, Yun Zhang, Tao Ma, Xueli Bai
BACKGROUND: Bile duct microenvironment plays several key roles in cholangiolithiasis occurrence. Sphincter of Oddi laxity (SOL) is associated with cholangiolithiasis, probably due to enhanced reflux of intestinal contents that changes the microenvironment. However, the microenvironment has not been investigated comprehensively. STUDY DESIGN: Patients with cholangiolithiasis were consecutively recruited and their bile was collected intraoperatively for high-throughput experiments...
March 2016: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/26763233/loss-of-%C3%AE-tubulin-acetylation-is-associated-with-tgf-%C3%AE-induced-epithelial-mesenchymal-transition
#16
Shuchen Gu, Yanjing Liu, Bowen Zhu, Ke Ding, Tso-Pang Yao, Fenfang Chen, Lixing Zhan, Pinglong Xu, Marcelo Ehrlich, Tingbo Liang, Xia Lin, Xin-Hua Feng
The epithelial-to-mesenchymal transition (EMT) is a process by which differentiated epithelial cells reprogram gene expression, lose their junctions and polarity, reorganize their cytoskeleton, increase cell motility and assume a mesenchymal morphology. Despite the critical functions of the microtubule (MT) in cytoskeletal organization, how it participates in EMT induction and maintenance remains poorly understood. Here we report that acetylated α-tubulin, which plays an important role in microtubule (MT) stabilization and cell morphology, can serve as a novel regulator and marker of EMT...
March 4, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/26718360/one-stage-laproendoscopic-procedure-versus-two-stage-procedure-in-the-management-for-gallstone-disease-and-biliary-duct-calculi-a-systemic-review-and-meta-analysis
#17
REVIEW
Pankaj Prasson, Xueli Bai, Qi Zhang, Tingbo Liang
BACKGROUND: Laparoscopic common bile duct exploration and endoscopic retrograde cholangiopancreatography (ERCP) are secure and effective techniques that recently been used to treat bile duct stones. The purpose of this research was to assess the intra-procedural efficacy and postprocedural upshots of the laparoscopic common bile duct exploration plus laparoscopic cholecystectomy (LCBDE) and ERCP plus laparoscopic cholecystectomy (ERCP + LC). METHODS: All studies contrasting one-stage (LCBDE) with two-stage (ERCP/EST + LC) managements in patients with concomitant gallstones and common bile duct (CBD) stones were included...
August 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/26593335/rg1-prevents-myocardial-hypoxia-reoxygenation-injury-by-regulating-mitochondrial-dynamics-imbalance-via-modulation-of-glutamate-dehydrogenase-and-mitofusin-2
#18
Gengting Dong, Tingbo Chen, Xuecong Ren, Zhifeng Zhang, Weixue Huang, Liang Liu, Pei Luo, Hua Zhou
PURPOSE: Mitochondrial dysfunction is a prominent feature of ischemia heart disease but the underlying mechanism of dynamics (fusion/fission) is still unclear. Here we investigated a novel function and underlying mechanism of Rg1 on an in vitro cardiomyocyte model of hypoxia/reoxygenation (H/R). METHODS: Cellular cytotoxicity was evaluated by MTT, mitochondrial viable staining, and cardiac marker detection. Mitochondrial function was evaluated by ATP content measurement, MMP determination, ROS, OCR and ECAR assay...
January 2016: Mitochondrion
https://www.readbyqxmd.com/read/26577499/duct-to-mucosa-vs-invagination-for-pancreaticojejunostomy-after-pancreaticoduodenectomy-a-prospective-randomized-controlled-trial-from-a-single-surgeon
#19
RANDOMIZED CONTROLLED TRIAL
Xueli Bai, Qi Zhang, Shunliang Gao, Jianying Lou, Guogang Li, Yun Zhang, Tao Ma, Yibo Zhang, Yuanliang Xu, Tingbo Liang
BACKGROUND: Pancreatic fistula (PF) is the most common significant complication after pancreaticoduodenectomy. Invagination and duct-to-mucosa anastomoses are anastomotic techniques that are commonly performed after pancreaticoduodenectomy. There are conflicting data on invagination vs duct-to-mucosa anastomoses about which is superior for minimizing the risk of PF. In addition, all previous studies involved multiple operating surgeons and failed to control for variation in surgeon expertise...
January 2016: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/26396475/a-case-report-on-successful-liver-transplantation-from-a-donor-with-polycystic-liver
#20
Xueli Bai, Longyun Ye, Wei Chen, Chunhui Cao, Liang Wang, Jiangtao Li, Shunliang Gao, Jianying Lou, Yun Zhang, Tingbo Liang
Organ shortage is a major issue faced by both transplant surgeons and patients. To enlarge the donor pool, marginal liver grafts are being increasingly used. In this paper, we present the case of a patient in whom a polycystic liver was successfully transplanted from a donor after brain and cardiac death. To our knowledge, this is the first successful case of liver transplantation using polycystic liver from a donation after brain and cardiac death.
October 2014: Indian Journal of Surgery
keyword
keyword
90055
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"