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Tingbo Liang

Wei Yu, Wei Hu, Yongjie Shui, Xiaoyang Zhu, Chao Li, Xiaoqiu Ren, Xueli Bai, Risheng Yu, Li Shen, Tingbo Liang, Lei Zheng, Qichun Wei
OBJECTIVES: To explore the areas at highest risk for postoperative pancreatic cancer local recurrence according to the spatial location of local failures, with the aim to provide a precise target volume for pancreatic cancer adjuvant radiotherapy. METHODS: Patients with pancreatic cancer who had undergone surgery for the primary tumor in pancreas at our institution from January 2010 to August 2015 were retrospectively analyzed. All local recurrences were plotted on the computed tomography (CT) image of a representative patient according to their relative coordinates to superior mesenteric artery (SMA) or celiac axis (CA)...
October 19, 2016: Radiation Oncology
Tao Wei, Wei Chen, Liang Wen, Jian Zhang, Qi Zhang, Jiaqi Yang, Hao Liu, Bryan Wei Chen, Yue Zhou, Xinhua Feng, Qi Yang, Xueli Bai, Tingbo Liang
G protein-coupled estrogen receptor (GPER) is a novel estrogen-binding receptor involved in many pathological conditions, including cancer. In this study, we investigated the effect of GPER on hepatocellular carcinoma (HCC). Our data show GPER knockout in a diethylnitrosamine (DEN)-induced mouse tumor model significantly accelerated liver tumorigenesis, accompanied by enhanced immune cell infiltration, fibrosis, and the production of inflammatory factors, such as interleukin-6 (IL-6). We further delineated the function of GPER in macrophages and hepatic stellate cells (HSCs)...
September 1, 2016: Cancer Letters
Qida Hu, Kai Wang, Xu Sun, Yang Li, Qihan Fu, Tingbo Liang, Guping Tang
Lack of efficient adjuvant therapy contributes to a high incidence of recurrence and metastasis of hepatocellular carcinoma (HCC). A novel therapeutic is required for adjuvant treatment of HCC. We developed a polymer-based nanosystem (ROSE) for functional gene therapy by synthesizing a supramolecular complex self-assembled from polycations and functional adamantyl modules. The ROSE system condensing tumor suppressor microRNA-34a (miR-34a) therapeutics becomes ROSE/miR-34a nanoparticles that could facilitate gene transfection in HCC cells with satisfied stability and efficiency, possibly due to proton sponge effect by polycations, PEGlyation protection, and controlled release by breakdown of disulfide bonds...
October 2016: Biomaterials
Yiwen Chen, Xueli Bai, Qi Zhang, Liang Wen, Wei Su, Qihan Fu, Xu Sun, Yu Lou, Jiaqi Yang, Jingying Zhang, Qi Chen, Jianxin Wang, Tingbo Liang
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and lethal cancer, with poor outcomes. Infection with the hepatitis B virus (HBV) may be associated as a worse prognosis for PDAC patients; however, the mechanisms involved in this process are unclear. We evaluated whether HBV infection leads to PDAC with a more aggressive phenotype, and attempted to elucidate the mechanisms involved. Clinicopathological data and outcomes from 64 patients with PDAC were collected and compared between serum HBsAg+ and HBsAg- patients...
September 28, 2016: Cancer Letters
Tao Xu, Jian Zhang, Wei Chen, Shengjing Pan, Xiao Zhi, Liang Wen, Yue Zhou, Bryan Wei Chen, Junyu Qiu, Yun Zhang, Qi Yang, Xinhua Feng, Xueli Bai, Tingbo Liang
AMP-activated protein kinase family member 5 (ARK5) overexpression has been reported in many human cancers, and ARK5 is associated with poor prognosis in hepatocellular carcinoma (HCC). However, whether ARK5 is involved in HCC chemoresistance is unclear. The present study aimed to investigate the role of ARK5 in HCC chemoresistance and the underlying mechanism. In this study, we found that SNU387 and SNU449 HCC cell lines overexpressing ARK5 displayed low doxorubicin sensitivity compared to Huh7 and Hep3B HCC cell lines with ARK5 low-expression...
July 28, 2016: Cancer Letters
Xueli Bai, Xiaoyu Zhang, Fangyan Lu, Guogang Li, Shunliang Gao, Jianying Lou, Yun Zhang, Tao Ma, Ji Wang, Wei Chen, Bingfeng Huang, Tingbo Liang
INTRODUCTION: The experience of implementing enhanced recovery after surgery (ERAS) programs in pancreatic surgery is limited. The aim of this study was to evaluate the feasibility of ERAS program in pancreatic surgery in an academic medical center of China. METHODS: Between May 2014 and August 2015, 124 patients managed with an ERAS program following pancreatic surgery (ERAS group), were compared to a historical cohort of 63 patients, treated with traditional perioperative care between August 2013 and April 2014 (no-ERAS group)...
July 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Liang Wen, Chao Liang, Enjiang Chen, Wei Chen, Feng Liang, Xiao Zhi, Tao Wei, Fei Xue, Guogang Li, Qi Yang, Weihua Gong, Xinhua Feng, Xueli Bai, Tingbo Liang
Hepatocellular carcinoma (HCC) is notoriously refractory to chemotherapy because of its tendency to develop multi-drug resistance (MDR), whose various underlying mechanisms make it difficult to target. The calcium signalling pathway is associated with many cellular biological activities, and is also a critical player in cancer. However, its role in modulating tumour MDR remains unclear. In this study, stimulation by doxorubicin, hypoxia and ionizing radiation was used to induce MDR in HCC cells. A sustained aggregation of intracellular calcium was observed upon these stimuli, while inhibition of calcium signalling enhanced the cells' sensitivity to various drugs by attenuating epithelial-mesenchymal transition (EMT), Hif1-α signalling and DNA damage repair...
2016: Scientific Reports
Liang Wen, Ping Gong, Chao Liang, Dawei Shou, Baoqing Liu, Yiwen Chen, Changqian Bao, Li Chen, Xiaowei Liu, Tingbo Liang, Weihua Gong
Myeloid-derived suppressor cells (MDSCs) and Th17 cells were first discovered in the fields of cancer and autoimmunity, respectively. In recent years, their activities have been explored in other biological and pathological conditions, such as infective diseases and solid organ transplantation. However, the interplay between MDSCs and Th17 cells and the mechanism of their interaction remain obscure. This review summarized and analyzed the relationship between MDSCs and Th17 cells, both of which participate in tumor, autoimmune disease, infection and other conditions...
June 7, 2016: Oncotarget
Tingbo Liang, Wei Su, Qi Zhang, Guogang Li, Shunliang Gao, Jianying Lou, Yun Zhang, Tao Ma, Xueli Bai
BACKGROUND: Bile duct microenvironment plays several key roles in cholangiolithiasis occurrence. Sphincter of Oddi laxity (SOL) is associated with cholangiolithiasis, probably due to enhanced reflux of intestinal contents that changes the microenvironment. However, the microenvironment has not been investigated comprehensively. STUDY DESIGN: Patients with cholangiolithiasis were consecutively recruited and their bile was collected intraoperatively for high-throughput experiments...
March 2016: Journal of the American College of Surgeons
Shuchen Gu, Yanjing Liu, Bowen Zhu, Ke Ding, Tso-Pang Yao, Fenfang Chen, Lixing Zhan, Pinglong Xu, Marcelo Ehrlich, Tingbo Liang, Xia Lin, Xin-Hua Feng
The epithelial-to-mesenchymal transition (EMT) is a process by which differentiated epithelial cells reprogram gene expression, lose their junctions and polarity, reorganize their cytoskeleton, increase cell motility and assume a mesenchymal morphology. Despite the critical functions of the microtubule (MT) in cytoskeletal organization, how it participates in EMT induction and maintenance remains poorly understood. Here we report that acetylated α-tubulin, which plays an important role in microtubule (MT) stabilization and cell morphology, can serve as a novel regulator and marker of EMT...
March 4, 2016: Journal of Biological Chemistry
Pankaj Prasson, Xueli Bai, Qi Zhang, Tingbo Liang
BACKGROUND: Laparoscopic common bile duct exploration and endoscopic retrograde cholangiopancreatography (ERCP) are secure and effective techniques that recently been used to treat bile duct stones. The purpose of this research was to assess the intra-procedural efficacy and postprocedural upshots of the laparoscopic common bile duct exploration plus laparoscopic cholecystectomy (LCBDE) and ERCP plus laparoscopic cholecystectomy (ERCP + LC). METHODS: All studies contrasting one-stage (LCBDE) with two-stage (ERCP/EST + LC) managements in patients with concomitant gallstones and common bile duct (CBD) stones were included...
August 2016: Surgical Endoscopy
Gengting Dong, Tingbo Chen, Xuecong Ren, Zhifeng Zhang, Weixue Huang, Liang Liu, Pei Luo, Hua Zhou
PURPOSE: Mitochondrial dysfunction is a prominent feature of ischemia heart disease but the underlying mechanism of dynamics (fusion/fission) is still unclear. Here we investigated a novel function and underlying mechanism of Rg1 on an in vitro cardiomyocyte model of hypoxia/reoxygenation (H/R). METHODS: Cellular cytotoxicity was evaluated by MTT, mitochondrial viable staining, and cardiac marker detection. Mitochondrial function was evaluated by ATP content measurement, MMP determination, ROS, OCR and ECAR assay...
January 2016: Mitochondrion
Xueli Bai, Qi Zhang, Shunliang Gao, Jianying Lou, Guogang Li, Yun Zhang, Tao Ma, Yibo Zhang, Yuanliang Xu, Tingbo Liang
BACKGROUND: Pancreatic fistula (PF) is the most common significant complication after pancreaticoduodenectomy. Invagination and duct-to-mucosa anastomoses are anastomotic techniques that are commonly performed after pancreaticoduodenectomy. There are conflicting data on invagination vs duct-to-mucosa anastomoses about which is superior for minimizing the risk of PF. In addition, all previous studies involved multiple operating surgeons and failed to control for variation in surgeon expertise...
January 2016: Journal of the American College of Surgeons
Xueli Bai, Longyun Ye, Wei Chen, Chunhui Cao, Liang Wang, Jiangtao Li, Shunliang Gao, Jianying Lou, Yun Zhang, Tingbo Liang
Organ shortage is a major issue faced by both transplant surgeons and patients. To enlarge the donor pool, marginal liver grafts are being increasingly used. In this paper, we present the case of a patient in whom a polycystic liver was successfully transplanted from a donor after brain and cardiac death. To our knowledge, this is the first successful case of liver transplantation using polycystic liver from a donation after brain and cardiac death.
October 2014: Indian Journal of Surgery
Xueli Bai, Qi Zhang, Song Wu, Xiaoyu Zhang, Mingbang Wang, Fusheng He, Tao Wei, Jiaqi Yang, Yu Lou, Zhiming Cai, Tingbo Liang
Pancreatic cancer has a poor prognosis and few effective treatments. The failure of treatment is partially due to the high heterogeneity of cancer cells within the tumor. T cells target and kill cancer cells by the specific recognition of cancer-associated antigens. In this study, T cells from primary tumor and blood of sixteen patients with pancreatic cancer were characterized by deep sequencing. T cells from blood of another eight healthy volunteers were also studied as controls. By analyzing the complementary determining region 3 (CDR3) gene sequence, we found no significant differences in the T cell receptor (TCR) repertoires between patients and healthy controls...
2015: Scientific Reports
Shuying Shen, Xiaocan Guo, Huan Yan, Yi Lu, Xinyan Ji, Li Li, Tingbo Liang, Dawang Zhou, Xin-Hua Feng, Jonathan C Zhao, Jindan Yu, Xing-Guo Gong, Lei Zhang, Bin Zhao
Organ size determination is one of the most intriguing unsolved mysteries in biology. Aberrant activation of the major effector and transcription co-activator YAP in the Hippo pathway causes drastic organ enlargement in development and underlies tumorigenesis in many human cancers. However, how robust YAP activation is achieved during organ size control remains elusive. Here we report that the YAP signaling is sustained through a novel microRNA-dependent positive feedback loop. miR-130a, which is directly induced by YAP, could effectively repress VGLL4, an inhibitor of YAP activity, thereby amplifying the YAP signals...
September 2015: Cell Research
Xiaoyu Shi, Risheng Que, Baoqing Liu, Mingming Li, Jinzhen Cai, Dawei Shou, Liang Wen, Dahai Liu, Li Chen, Tingbo Liang, Weihua Gong
Since pro-inflammatory cytokine IL-21 and its receptor (IL-21R) are closely involved in regulating both innate and adaptive immune responses, it is conceivable that they may play important roles in the field of organ transplantation. IL-21/IL21-R regulates immune activities of CD8+ T cells, Tfh cells, Th17 cells, B cells, NK cells, dendritic cells and stimulates dendritic cells to produce high level of IL-6, TNF-alpha, and CCL2. However, their roles and underlying mechanisms remain obscure. Our present study is the first describing the role of IL-21 signaling pathway in transplant biology...
January 2016: Transplantation Reviews
Xiao Zhi, Wei Chen, Fei Xue, Chao Liang, Bryan Wei Chen, Yue Zhou, Liang Wen, Liqiang Hu, Jian Shen, Xueli Bai, Tingbo Liang
Despite its relative rarity, pancreatic ductal adenocarcinoma (PDAC) accounts for a large percentage of cancer deaths. In this study, we investigated the in vitro efficacy of OSI-027, a selective inhibitor of mammalian target of rapamycin complex 1 (mTORC1) and mTORC2, to treat PDAC cell lines alone, and in combination with gemcitabine (GEM). Similarly, we tested the efficacy of these two compounds in a xenograft mouse model of PDAC. OSI-027 significantly arrested cell cycle in G0/G1 phase, inhibited the proliferation of Panc-1, BxPC-3, and CFPAC-1 cells, and downregulated mTORC1, mTORC2, phospho-Akt, phospho-p70S6K, phospho-4E-BP1, cyclin D1, and cyclin-dependent kinase 4 (CDK4) in these cells...
September 22, 2015: Oncotarget
Pintong Huang, Ying Zhang, Jian Chen, Weihui Shentu, Yu Sun, Zhijian Yang, Tingbo Liang, Shuyuan Chen, Zhaoxia Pu
Ultrasonic cavitation is a novel potential approach for cancer treatment. We optimized the techniques of ultrasonic cavitation to enhance antitumor efficacy in a mouse model with human pancreatic cancer. A polydisperse MB contrast agent formulation (TS-P) with a mean number diameter of 1.9 μm was depleted in small diameter particles by differential centrifugation, producing an "up-sized" size distribution (TS-PL) possessing a mean diameter of 2.9 μm. Mice bearing the XPA-1-RFP pancreatic tumor were treated daily for 3 consecutive days with either up-sized or standard MB...
August 21, 2015: Oncotarget
Yue Zhou, Chao Liang, Fei Xue, Wei Chen, Xiao Zhi, Xinhua Feng, Xueli Bai, Tingbo Liang
Doxorubicin is a conventional and effective chemotherapy drug against hepatocellular carcinoma (HCC). However, during long-term doxorubicin monotherapy, HCC cells may eventually develop acquired-resistance to doxorubicin which results in recurrence and a poor prognosis. Salinomycin, an ionophore antibiotic, was recently reported to selectively kill human cancer stem cells (CSCs) which were response for chemoresistance. In this study, salinomycin was found to exert synergistic cytotoxicity with doxorubicin in HCC cells and be capable of inhibiting doxorubicin-induced epithelial-mesenchymal transition (EMT), an important cellular process involved in the acquired chemoresistance of tumors...
April 30, 2015: Oncotarget
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