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https://www.readbyqxmd.com/read/27908810/emergent-treatment-of-a-ruptured-thoraco-abdominal-aortic-aneurysm-by-off-label-rescue-implantation-of-the-ovation-%C3%A2-stent-graft-in-nonagenarians-patient
#1
Chiara Pranteda, Pasqualino Sirignano, Federica Fornelli, Wassim Mansour, Nunzio Montelione, Laura Capoccia, Francesco Speziale
We report a case of a compassionate treatment of a ruptured thoraco-abdominal aortic aneurysm in a 92-year-old patient. Patient was admitted to our emergency department for acute onset of pain irradiating to the back. Computed tomographic angiography showed the presence of a thoraco-abdominal aortic aneurysm with a contained rupture at infrarenal level. Given of the presence of a relative healthy visceral aorta, we decided to treat the patient by Ovation(®) (Endologix, Irvine, CA - USA) implantation in an off-label fashion...
November 28, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27901330/critically-ill-octogenarians-and-nonagenarians-evaluation-of-long-term-outcomes-post-hospital-trajectories-and-quality-of-life-one-year-and-seven-years-after-icu-discharge
#2
Sandra Oeyen, Joris Vermassen, Ruth Piers, Dominique Benoit, Lieven Annemans, Johan Decruyenaere
BACKGROUND: To investigate long-term outcomes, post-hospital trajectories, and quality of life (QOL) in patients ≥ 80 years admitted to the intensive care unit (ICU) of a tertiary care hospital. METHODS: A 1-year prospective observational cohort analysis was performed. All consecutive patients ≥ 80 years admitted to the ICU were screened for inclusion. Demographics, comorbidity, organ failures, and outcomes were analyzed. QOL before admission, 3 months, 1 year, and 7 years after ICU discharge was assessed using EuroQoL-5D (EQ-5D) and Medical Outcomes Study 36-item Short Form Health Survey (SF-36) questionnaires...
November 30, 2016: Minerva Anestesiologica
https://www.readbyqxmd.com/read/27901180/ultrasonographic-assessment-of-thyroid-volume-in-oldest-old-individuals
#3
Glaucia Cruzes Duarte, Lara Miguel Quirino Araujo, Felix Magalhães, Clineu Mello Almada, Maysa Seabra Cendoroglo
Objective: The aim of this study was to describe the relationship between thyroid volume and age, gender, anthropometric characteristics, and echogenicity in oldest-old subjects in an iodine-sufficient area. Subjects and methods: The study included 81 independent elderly individuals aged ≥ 80 years (65 [80.2%] women). We determined these individuals' anthropometric characteristics, body mass index (BMI), and lean body mass, as well as thyroid volume and echogenicity by ultrasonography...
November 24, 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27898433/transcatheter-aortic-valve-implantation-in-nonagenarians
#4
Adam Penkalla, Joerg Kempfert, Axel Unbehaun, Semih Buz, Thorsten Drews, Miralem Pasic, Volkmar Falk
OBJECTIVE: In this report, we assess the outcome of transcatheter aortic valve implantation (TAVI) in nonagenarians at our institution during a 6-year period. METHODS: Between April 2008 and July 2014, 40 patients with a mean ± SD age of 91.8 ± 2.3 years (range, 90-98 years) underwent TAVI. Thirty-three patients (82.5%) received transapical TAVI, and seven patients (17.5%) received transfemoral TAVI. Baseline characteristics were as follows: mean ± SD EuroSCORE II, 23...
November 28, 2016: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/27891576/changes-in-drug-use-and-polypharmacy-after-the-age-of-90-a-longitudinal-study-of-the-danish-1905-cohort
#5
Jonas W Wastesson, Anna Oksuzyan, Jacob von Bornemann Hjelmborg, Kaare Christensen
OBJECTIVES: To determine the longitudinal development of drug use in very old adults. DESIGN: Longitudinal cohort study with waves in 1998, 2000, 2002, and 2005. SETTING: Nationwide study in Denmark. PARTICIPANTS: All living Danes born in 1905 were approached in 1998; 2,262 responded at baseline. MEASUREMENTS: Self-reported use of regularly taken drugs. Mean and median number of drugs and growth curve models were used to identify the change in number of drugs as the cohort aged from 92 to 100...
November 28, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27881971/familial-longevity-is-not-associated-with-major-differences-in-the-hypothalamic-pituitary-gonadal-axis-in-healthy-middle-aged-men
#6
Evie van der Spoel, Ferdinand Roelfsema, Steffy W Jansen, Abimbola A Akintola, Bart E Ballieux, Christa M Cobbaert, Gerard J Blauw, P Eline Slagboom, Rudi G J Westendorp, Hanno Pijl, Diana van Heemst
CONTEXT: A trade-off between fertility and longevity possibly exists. The association of the male hypothalamic-pituitary-gonadal (HPG) axis with familial longevity has not yet been investigated. OBJECTIVE: To study 24-h hormone concentration profiles of the HPG axis in men enriched for familial longevity and controls. DESIGN: We frequently sampled blood over 24 h in 10 healthy middle-aged male offspring of nonagenarian participants from the Leiden Longevity Study together with 10 male age-matched controls...
2016: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/27880854/increased-paternal-age-at-conception-is-associated-with-transcriptomic-changes-involved-in-mitochondrial-function-in-elderly-individuals
#7
Tapio Nevalainen, Laura Kananen, Saara Marttila, Juulia Jylhävä, Marja Jylhä, Antti Hervonen, Mikko Hurme
The increased paternal age at conception (PAC) has been associated with autism spectrum disorder (ASD), schizophrenia and other neurodevelopmental disorders, thus raising questions that imply, potential health concerns in the offspring. As opposed to female oogonia, the male germ cells undergo hundreds of cell divisions during the fertile years. Thus, the advanced paternal age is associated with increase of point mutations in the male spermatogonia DNA, implying that this could be the major driving mechanism behind the paternal age effect observed in the offspring...
2016: PloS One
https://www.readbyqxmd.com/read/27878802/improvement-of-quality-of-life-following-transcatheter-aortic-valve-implantation-in-elderly-multi-centre-study-based-on-polish-national-tavi-registry
#8
Aleksandra Stańska, Dariusz Jagielak, Maciej Brzeziński, Michał Zembala, Wojciech Wojakowski, Janusz Kochman, Zenon Huczek, Adam Witkowski, Marian Zembala
BACKGROUND: Transcatheter aortic valve implantation is an effective therapeutic method for elderly high-risk patients with symptomatic severe aortic stenosis, not eligible for surgical treatment. AIM: The aim of the study was to evaluate short-term changes in elderly's quality of life following TAVI, based on POL-TAVI registry. METHODS: One hundred eighty four octogenarians' and nonagenarians' samples from POL-TAVI database were included in the study...
November 23, 2016: Kardiologia Polska
https://www.readbyqxmd.com/read/27808666/multimodal-therapy-is-feasible-in-elderly-anal-cancer-patients
#9
Jon Espen Dale, Sigrun Sebjørnsen, Sabine Leh, Cornelia Rösler, Stein Aaserud, Bjørn Møller, Øystein Fluge, Christian Erichsen, Saied Nadipour, Hartwig Kørner, Frank Pfeffer, Olav Dahl
BACKGROUND: Many patients are diagnosed with an anal cancer in high ages. We here present the outcome after oncological therapy for patients above 80 years compared with younger patients. MATERIALS AND METHODS: A series of 213 consecutive patients was diagnosed and treated at a single institution from 1984 to 2009. The patients received similar radiation doses but with different techniques, thus progressively sparing more normal tissues. The majority of patients also had simultaneous [5-fluorouracil (5FU) and mitomycin C] or induction chemotherapy (cisplatin and 5FU)...
November 3, 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27790805/drug-use-among-complete-responders-partial-responders-and-non-responders-in-a-longitudinal-survey-of-nonagenarians-analysis-of-prescription-register-data
#10
Jonas W Wastesson, Lotte Rasmussen, Anna Oksuzyan, Jesper Hallas, Kaare Christensen, Anton Pottegård
PURPOSE: In observational studies, non-response can limit representativity and introduce bias. We aimed to investigate the longitudinal changes in the number of used drugs among complete responders, partial responders, and non-responders in a whole birth cohort of Danish nonagenarians participating in a longitudinal survey. METHODS: We obtained prescription data on all individuals born in 1905 and living in Denmark when the Danish 1905 cohort study was initiated in 1998 (n = 3600) using the Danish National Prescription Registry...
October 28, 2016: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/27789451/endovascular-stroke-treatment-of-nonagenarians
#11
M Möhlenbruch, J Pfaff, S Schönenberger, S Nagel, J Bösel, C Herweh, P Ringleb, M Bendszus, S Stampfl
BACKGROUND AND PURPOSE: Although endovascular treatment has become a standard therapy in patients with acute stroke, the benefit for very old patients remains uncertain. The purpose of this study was the evaluation of procedural and outcome data of patients ≥90 years undergoing endovascular stroke treatment. MATERIALS AND METHODS: We retrospectively analyzed prospectively collected data of patients ≥90 years in whom endovascular stroke treatment was performed between January 2011 and January 2016...
October 27, 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/27754234/os-34-01-association-of-combination-of-hypertension-and-diabetes-with-cognitive-function-among-the-70-years-old-japanese-general-population-from-longitudinal-observation-in-the-sonic-study
#12
Hirochika Ryuno, Kei Kamide, Yasuyuki Gondo, Mai Kabayama, Ken Sugimoto, Takeshi Nakagawa, Kazunori Ikebe, Hiroki Inagaki, Yukie Masui, Yasumichi Arai, Tatsuro Ishizaki, Hiromi Rakugi
OBJECTIVE: It is well-documented that midlife hypertension (HT) is associated with decline of cognitive function. Recently, we reported that the influence of HT and/or elevated blood pressure on the progression of cognitive decline was attenuated at late life aged 70 of the general population in cross-sectional analysis. The purpose of this study is to investigate the 3 years' longitudinal effect of HT and additive risk factors on decline of cognitive function for 70-year-old general Japanese population in the Septuagenarians, Octogenarians and Nonagenarians Investigation with Centenarians (SONIC) study, which is a narrow age range cohort...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754070/os-18-02-antihypertensive-treatment-and-risk-of-brain-ischemia-due-to-carotid-stenosis-in-a-survey-of-hospitalised-patients-aged-90-years-and-older
#13
Jürgen Bohlender, Jürg Nussberger, Beate Bohlender
OBJECTIVE: In elderly hypertensive patients, systolic blood pressure (sBP) goals recommended by US and European guidelines (ESH) for the initiation of treatment are more liberal than in younger patients because of an increased risk of treatment-associated side-effects and hypotension. Carotid stenosis increases with age and poses a risk of brain ischemia if hypotension occurs. Its relevance for the routine care of elderly hypertensives, however, remains unclear. We analyzed data on precerebral artery morphology and BP evolution from a survey of aged hospitalized patients...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27748531/longitudinal-study-of-factors-affecting-taste-sense-decline-in-old-old-individuals
#14
Taiji Ogawa, Masahiro Uota, Kazunori Ikebe, Yasumichi Arai, Kei Kamide, Yasuyuki Gondo, Yukie Masui, Tatsuro Ishizaki, Chisato Inomata, Hajime Takeshita, Yusuke Mihara, Kodai Hatta, Yoshinobu Maeda
The sense of taste plays a pivotal role for personal assessment of the nutritional value, safety, and quality of foods. Although it is commonly recognized that taste sensitivity decreases with age, alterations in that sensitivity over time in an old-old population have not been previously reported. Furthermore, no known studies utilized comprehensive variables regarding taste changes and related factors for assessments. Here, we report novel findings from a 3-year longitudinal study model aimed to elucidate taste sensitivity decline and its related factors in old-old individuals...
October 17, 2016: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/27717124/is-colorectal-surgery-beyond-the-age-of-80-still-feasible-with-acceptable-mortality-an-analysis-of-the-predictive-value-of-cr-possum-and-life-expectancy-after-hospital-discharge
#15
Anthony de Buck van Overstraeten, Jasper Stijns, Annouschka Laenen, Steffen Fieuws, Albert M Wolthuis, André D'Hoore
AIM: Increased morbidity and mortality could mitigate the positive effect of surgery in elderly patients undergoing colorectal resections. This retrospective study aims to describe early morbidity and mortality together with long-term survival in octogenarians and nonagenarians undergoing colorectal surgery. Predictors for in-hospital mortality will be identified. The predictive value of CR-POSSUM will be assessed. METHOD: Data on consecutive patients of 80 years old or more, undergoing a colorectal resection in our center from 2004 until 2010 were analyzed...
October 7, 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/27714717/annual-prognostic-factors-in-chronic-heart-failure-in-patients-over-80-years-old
#16
Anna Cichocka-Radwan, Małgorzata Lelonek
BACKGROUND: In the elderly the most common cause of hospitalization and the leading cause of death is heart failure. AIM: The purpose was to determine prognostic factors in chronic heart failure (CHF) in octogenarians and nonagenarians. METHODS: The analysis included 197 consecutive patients older than 80 years old (mean age 83.63+3.01 years; 46.19% of men) hospitalized in 2010-2013 in the Department of Cardiology due to CHF. Sixty two parameters were investigated such as: age, gender, NYHA functional class, body mass index, blood pressure, other comorbidities, the parameters of the 12-lead resting ECG and the echocardiography, the results of basic laboratory tests and selected biomarkers, including N-terminal pro-B-type natriuretic peptide (NT-proBNP), high-sensitive troponin T (hs-TnT), high-sensitive C-reactive protein (hs-CRP)...
October 7, 2016: Kardiologia Polska
https://www.readbyqxmd.com/read/27714398/seasonal-influenza-in-octogenarians-and-nonagenarians-admitted-to-a-general-hospital-epidemiology-clinical-presentation-and-prognostic-factors
#17
J M Ramos, M M García-Navarro, M P González de la Aleja, R Sánchez-Martínez, A Gimeno-Gascón, S Reus, E Merino, J C Rodríguez-Díaz, J Portilla
OBJECTIVE: Seasonal influenza is responsible for high annual morbidity and mortality worldwide, especially in elderly patients. The aim of the study was to analyse the epidemiological, clinical and prognostic features of influenza in octogenarians and nonagenarians admitted to a general hospital, as well as risk factors associated with mortality. METHODS: Retrospective, cross-sectional, descriptive study in patients admitted and diagnosed with influenza by molecular biology in the General University Hospital of Alicante from 1 January to 31 April 2015...
December 2016: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/27672102/systemic-age-associated-dna-hypermethylation-of-elovl2-gene-in-vivo-and-in-vitro-evidences-of-a-cell-replication-process
#18
Maria Giulia Bacalini, Joris Deelen, Chiara Pirazzini, Marco De Cecco, Cristina Giuliani, Catia Lanzarini, Francesco Ravaioli, Elena Marasco, Diana van Heemst, H Eka D Suchiman, Roderick Slieker, Enrico Giampieri, Rina Recchioni, Fiorella Mercheselli, Stefano Salvioli, Giovanni Vitale, Fabiola Olivieri, Annemieke M W Spijkerman, Martijn E T Dollé, John M Sedivy, Gastone Castellani, Claudio Franceschi, Pieternella E Slagboom, Paolo Garagnani
Epigenetic remodeling is one of the major features of the aging process. We recently demonstrated that DNA methylation of ELOVL2 and FHL2 CpG islands is highly correlated with age in whole blood. Here we investigated several aspects of age-associated hypermethylation of ELOVL2 and FHL2 We showed that ELOVL2 methylation is significantly different in primary dermal fibroblast cultures from donors of different ages. Using epigenomic data from public resources, we demonstrated that most of the tissues show ELOVL2 and FHL2 hypermethylation with age...
September 26, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27648646/hysterectomy-for-uterine-cancer-in-the-elderly-a-comparison-between-laparoscopic-and-robot-assisted-techniques
#19
Andrew Zakhari, Nicholas Czuzoj-Shulman, Andrea R Spence, Walter H Gotlieb, Haim A Abenhaim
OBJECTIVE: The mainstay of treatment for uterine corpus cancer is surgical, and the gold standard approach has become minimally invasive surgery. The aim of this study is to compare the perioperative complications and demographics of patients 80 years old or more undergoing robotic and laparoscopic hysterectomy for uterine cancer. MATERIALS AND METHODS: Using the Nationwide Inpatient Sample, we retrospectively identified all women aged 80 years or older who had hysterectomies for uterine cancer by either modality...
September 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27643194/os-34-01-association-of-combination-of-hypertension-and-diabetes-with-cognitive-function-among-the-70-years-old-japanese-general-population-from-longitudinal-observation-in-the-sonic-study
#20
Hirochika Ryuno, Kei Kamide, Yasuyuki Gondo, Mai Kabayama, Ken Sugimoto, Takeshi Nakagawa, Kazunori Ikebe, Hiroki Inagaki, Yukie Masui, Yasumichi Arai, Tatsuro Ishizaki, Hiromi Rakugi
OBJECTIVE: It is well-documented that midlife hypertension (HT) is associated with decline of cognitive function. Recently, we reported that the influence of HT and/or elevated blood pressure on the progression of cognitive decline was attenuated at late life aged 70 of the general population in cross-sectional analysis. The purpose of this study is to investigate the 3 years' longitudinal effect of HT and additive risk factors on decline of cognitive function for 70-year-old general Japanese population in the Septuagenarians, Octogenarians and Nonagenarians Investigation with Centenarians (SONIC) study, which is a narrow age range cohort...
September 2016: Journal of Hypertension
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