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https://www.readbyqxmd.com/read/28230198/longitudinal-association-of-hypertension-and-diabetes-mellitus-with-cognitive-functioning-in-a-general-70-year-old-population-the-sonic-study
#1
Hirochika Ryuno, Kei Kamide, Yasuyuki Gondo, Mai Kabayama, Ryosuke Oguro, Chikako Nakama, Serina Yokoyama, Motonori Nagasawa, Satomi Maeda-Hirao, Yuki Imaizumi, Miyuki Takeya, Hiroko Yamamoto, Masao Takeda, Yoichi Takami, Norihisa Itoh, Yasushi Takeya, Koichi Yamamoto, Ken Sugimoto, Takeshi Nakagawa, Saori Yasumoto, Kazunori Ikebe, Hiroki Inagaki, Yukie Masui, Michiyo Takayama, Yasumichi Arai, Tatsuro Ishizaki, Ryutaro Takahashi, Hiromi Rakugi
Both hypertension and diabetes in middle-aged individuals have been suggested to be predictive indicators of cognitive decline. However, the association of hypertension, diabetes and their combination with cognitive functioning is still controversial in older people. The purpose of this study was to investigate the association between cognitive decline and hypertension, diabetes, and their combination in 70-year-old people based on a 3-year longitudinal analysis. Four hundred and fifty-four people aged 70 (±1) years who participated in the Japanese longitudinal cohort study of Septuagenarians, Octogenarians and Nonagenarians Investigation with Centenarians (SONIC) were recruited randomly from a general population and were monitored for 3 years...
February 23, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28193134/non-coronary-vascular-calcification-bone-mineral-density-and-muscle-mass-in-institutionalized-frail-nonagenarians
#2
Fernando Idoate, Eduardo L Cadore, Alvaro Casas-Herrero, Fabricio Zambom-Ferraresi, Nicolas Martinez-Velilla, Leocadio Rodriguez-Mañas, Pedro M Azkarate, Martim Bottaro, Robison Ramírez-Vélez, Mikel Izquierdo
The purpose of this study was to compare the vascular calcification at thoracic (TAC) and ab-dominal (AAC) aorta, iliac (IAC) and femoral (FAC) arteries, and bone mineral density (BMD) of the lumbar vertebrae between frail and robust nonagenarians, as well as to verify the associations between vascular calcification with BMD, muscle tissue quality and quantity in both groups. Forty-two elderly subjects participated in this study: 29 institutionalized frail (92.0±3.2 years) and 13 ro-bust (89.0±4.0 years) elderly participants...
February 14, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28190591/-hip-fracture-and-inferior-gluteal-artery-laceration-in-a-nonagenarian-woman-taking-anticoagulants
#3
Daniel Aedo-Martín, Noelia Alonso-Gómez, Rafael García-Cañas, Marcos Fernández-Gayol
No abstract text is available yet for this article.
February 9, 2017: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/28185060/simultaneous-bilateral-total-hip-arthroplasties-in-nonagenarians
#4
REVIEW
F R Power, D T Cawley, P D Curtin
Total hip arthroplasty (THA) is an effective and durable treatment option for hip osteoarthritis (OA). As life expectancy continues to increase, so too will the demand for joint arthroplasty in the 10th decade of life, frequently in cases involving osteoarthritis of both hips. Simultaneous bilateral total hip arthroplasty (SBTHA) is a valuable therapeutic option in appropriately selected patients with bilateral degenerative hip disease, although its use in the very elderly is poorly reported on in the literature...
February 9, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28061996/comparative-outcomes-of-surgical-and-transcatheter-aortic-valve-replacement-for-aortic-stenosis-in-nonagenarians
#5
Chad J Zack, Fahad Al-Qahtani, Akram Kawsara, Mohammed Al-Hijji, Ali Hama Amin, Mohamad Alkhouli
Transcatheter aortic valve replacement (TAVR) emerged as a promising alternative to surgical aortic valve replacement (SAVR) in extreme-aged patients with severe aortic stenosis (AS). Data on the outcomes of TAVR or SAVR in nonagenarians are limited. The Nationwide Inpatient Sample was used to identify patients aged 90 years or older who underwent TAVR or SAVR from 2004 to 2013. In-hospital morbidity and mortality were assessed. From 2004 to 2013, 9,066 (national estimate) nonagenarians underwent aortic valve replacement...
December 18, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/28050718/national-trends-following-decompression-discectomy-and-fusion-in-octogenarians-and-nonagenarians
#6
Doniel Drazin, Carlito Lagman, Siddharth Bhargava, Miriam Nuño, Terrence T Kim, J Patrick Johnson
BACKGROUND: The National Inpatient Sample (NIS) database is used to evaluate a wide variety of surgical procedures across a range of specialties. The authors of this study assess national trends of the three commonest spine procedures performed (decompression, fusion, and discectomy) in patients between the ages of 80 and 100 years (octogenarians and nonagenarians). METHODS: The NIS database was queried to identify patients between the ages of 80 and 100 with a primary diagnosis of spinal stenosis, disk herniation without myelopathy, or protrusion due to degeneration of spine/disk disorders and who have undergone spinal decompression, fusion, or discectomy between the years 1998 and 2011...
March 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28040447/demographics-phenotypic-health-characteristics-and-genetic-analysis-of-centenarians-in-china
#7
REVIEW
Yi Zeng, Qiushi Feng, Danan Gu, James W Vaupel
After a brief introduction to the background, significance and unique features of the centenarian population in China, we describe the Chinese Longitudinal Healthy Longevity Study (CLHLS), which is the world's largest study of centenarians, nonagenarians, octogenarians, and compatible young-old aged 65-79. Based on the CLHLS data and other relevant studies, we summarize demographic and socioeconomic characteristics as well as self-reported and objectively-tested health indicators of centenarians in China, with an emphasis on gender differences and rural/urban disparities...
December 28, 2016: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/27999751/responses-to-immune-checkpoint-inhibitors-in-nonagenarians
#8
Romany A N Johnpulle, Robert M Conry, Jeffrey A Sosman, Igor Puzanov, Douglas B Johnson
The incidence of melanoma continues to rise with the most rapid increase seen in the elderly population. Historically, elderly patients with advanced melanoma have had dismal clinical outcomes, in part, due to distinct tumor biology, and often ineligibility for effective therapies during their development. In addition, due to relatively few geriatric patients being accrued to clinical trials of novel immunotherapeutics, there is a paucity of data regarding their safety and efficacy. Herein, we present the clinical course of three consecutive nonagenarians (≥90 y old) with metastatic melanoma, who were treated with single-agent or combination immune checkpoint inhibitors...
2016: Oncoimmunology
https://www.readbyqxmd.com/read/27970142/tct-755-comparison-of-clinical-profile-and-outcomes-after-transcatheter-aortic-valve-replacement-in-nonagenarians-versus-younger-patients
#9
Rafael Alexandre Meneguz-Moreno, Alfredo Nunes Ferreira Neto, Auristela Ramos, Dimytri Siqueira, David Le Bihan, Rodrigo Barretto, Adriana Moreira, Alexandre Abizaid, Amanda Sousa, J Eduardo Sousa
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969681/tct-334-predictors-of-outcomes-among-nonagenarians-undergoing-percutaneous-coronary-intervention-a-national-veterans-affairs-database-study
#10
Abhishek Sawant, Vasvi Singh, Kevin Josey, Meg Plomondon, Thomas Maddox, Ali Sheikh, Zaid Said, Bharath Rajagopalan, Deepak Bhatt, John Corbelli
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27908810/emergent-treatment-of-a-ruptured-thoraco-abdominal-aortic-aneurysm-by-off-label-rescue-implantation-of-the-ovation-%C3%A2-stent-graft-in-nonagenarians-patient
#11
Chiara Pranteda, Pasqualino Sirignano, Federica Fornelli, Wassim Mansour, Nunzio Montelione, Laura Capoccia, Francesco Speziale
We report a case of a compassionate treatment of a ruptured thoraco-abdominal aortic aneurysm in a 92-year-old patient. Patient was admitted to our emergency department for acute onset of pain irradiating to the back. Computed tomographic angiography showed the presence of a thoraco-abdominal aortic aneurysm with a contained rupture at infrarenal level. Given of the presence of a relative healthy visceral aorta, we decided to treat the patient by Ovation(®) (Endologix, Irvine, CA - USA) implantation in an off-label fashion...
November 28, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27901330/critically-ill-octogenarians-and-nonagenarians-evaluation-of-long-term-outcomes-post-hospital-trajectories-and-quality-of-life-one-year-and-seven-years-after-icu-discharge
#12
Sandra Oeyen, Joris Vermassen, Ruth Piers, Dominique Benoit, Lieven Annemans, Johan Decruyenaere
BACKGROUND: To investigate long-term outcomes, post-hospital trajectories, and quality of life (QOL) in patients ≥ 80 years admitted to the intensive care unit (ICU) of a tertiary care hospital. METHODS: A 1-year prospective observational cohort analysis was performed. All consecutive patients ≥ 80 years admitted to the ICU were screened for inclusion. Demographics, comorbidity, organ failures, and outcomes were analyzed. QOL before admission, 3 months, 1 year, and 7 years after ICU discharge was assessed using EuroQoL-5D (EQ-5D) and Medical Outcomes Study 36-item Short Form Health Survey (SF-36) questionnaires...
November 30, 2016: Minerva Anestesiologica
https://www.readbyqxmd.com/read/27901180/ultrasonographic-assessment-of-thyroid-volume-in-oldest-old-individuals
#13
Glaucia Cruzes Duarte, Lara Miguel Quirino Araujo, Felix Magalhães, Clineu Mello Almada, Maysa Seabra Cendoroglo
Objective: The aim of this study was to describe the relationship between thyroid volume and age, gender, anthropometric characteristics, and echogenicity in oldest-old subjects in an iodine-sufficient area. Subjects and methods: The study included 81 independent elderly individuals aged ≥ 80 years (65 [80.2%] women). We determined these individuals' anthropometric characteristics, body mass index (BMI), and lean body mass, as well as thyroid volume and echogenicity by ultrasonography...
November 24, 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27898433/transcatheter-aortic-valve-implantation-in-nonagenarians
#14
Adam Penkalla, Joerg Kempfert, Axel Unbehaun, Semih Buz, Thorsten Drews, Miralem Pasic, Volkmar Falk
OBJECTIVE: In this report, we assess the outcome of transcatheter aortic valve implantation (TAVI) in nonagenarians at our institution during a 6-year period. METHODS: Between April 2008 and July 2014, 40 patients with a mean ± SD age of 91.8 ± 2.3 years (range, 90-98 years) underwent TAVI. Thirty-three patients (82.5%) received transapical TAVI, and seven patients (17.5%) received transfemoral TAVI. Baseline characteristics were as follows: mean ± SD EuroSCORE II, 23...
November 2016: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/27891576/changes-in-drug-use-and-polypharmacy-after-the-age-of-90-a-longitudinal-study-of-the-danish-1905-cohort
#15
Jonas W Wastesson, Anna Oksuzyan, Jacob von Bornemann Hjelmborg, Kaare Christensen
OBJECTIVES: To determine the longitudinal development of drug use in very old adults. DESIGN: Longitudinal cohort study with waves in 1998, 2000, 2002, and 2005. SETTING: Nationwide study in Denmark. PARTICIPANTS: All living Danes born in 1905 were approached in 1998; 2,262 responded at baseline. MEASUREMENTS: Self-reported use of regularly taken drugs. Mean and median number of drugs and growth curve models were used to identify the change in number of drugs as the cohort aged from 92 to 100...
January 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27881971/familial-longevity-is-not-associated-with-major-differences-in-the-hypothalamic-pituitary-gonadal-axis-in-healthy-middle-aged-men
#16
Evie van der Spoel, Ferdinand Roelfsema, Steffy W Jansen, Abimbola A Akintola, Bart E Ballieux, Christa M Cobbaert, Gerard J Blauw, P Eline Slagboom, Rudi G J Westendorp, Hanno Pijl, Diana van Heemst
CONTEXT: A trade-off between fertility and longevity possibly exists. The association of the male hypothalamic-pituitary-gonadal (HPG) axis with familial longevity has not yet been investigated. OBJECTIVE: To study 24-h hormone concentration profiles of the HPG axis in men enriched for familial longevity and controls. DESIGN: We frequently sampled blood over 24 h in 10 healthy middle-aged male offspring of nonagenarian participants from the Leiden Longevity Study together with 10 male age-matched controls...
2016: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/27880854/increased-paternal-age-at-conception-is-associated-with-transcriptomic-changes-involved-in-mitochondrial-function-in-elderly-individuals
#17
Tapio Nevalainen, Laura Kananen, Saara Marttila, Juulia Jylhävä, Marja Jylhä, Antti Hervonen, Mikko Hurme
The increased paternal age at conception (PAC) has been associated with autism spectrum disorder (ASD), schizophrenia and other neurodevelopmental disorders, thus raising questions that imply, potential health concerns in the offspring. As opposed to female oogonia, the male germ cells undergo hundreds of cell divisions during the fertile years. Thus, the advanced paternal age is associated with increase of point mutations in the male spermatogonia DNA, implying that this could be the major driving mechanism behind the paternal age effect observed in the offspring...
2016: PloS One
https://www.readbyqxmd.com/read/27878802/improvement-of-quality-of-life-following-transcatheter-aortic-valve-implantation-in-the-elderly-a-multi-centre-study-based-on-the-polish-national-tavi-registry
#18
Aleksandra Stańska, Dariusz Jagielak, Maciej Brzeziński, Michał Zembala, Wojciech Wojakowski, Janusz Kochman, Zenon Huczek, Adam Witkowski, Marian Zembala
BACKGROUND: Transcatheter aortic valve implantation (TAVI) is an effective therapeutic method for elderly high-risk patients with symptomatic severe aortic stenosis, not eligible for surgical treatment. AIM: The aim of the study was to evaluate short-term changes in elderly people's quality of life following TAVI, based on the POL-TAVI registry. METHODS: One hundred and eighty-four octogenarians' and nonagenarians' samples from the POL-TAVI database were included in the study...
2017: Kardiologia Polska
https://www.readbyqxmd.com/read/27808666/multimodal-therapy-is-feasible-in-elderly-anal-cancer-patients
#19
Jon Espen Dale, Sigrun Sebjørnsen, Sabine Leh, Cornelia Rösler, Stein Aaserud, Bjørn Møller, Øystein Fluge, Christian Erichsen, Saied Nadipour, Hartwig Kørner, Frank Pfeffer, Olav Dahl
BACKGROUND: Many patients are diagnosed with an anal cancer in high ages. We here present the outcome after oncological therapy for patients above 80 years compared with younger patients. MATERIALS AND METHODS: A series of 213 consecutive patients was diagnosed and treated at a single institution from 1984 to 2009. The patients received similar radiation doses but with different techniques, thus progressively sparing more normal tissues. The majority of patients also had simultaneous [5-fluorouracil (5FU) and mitomycin C] or induction chemotherapy (cisplatin and 5FU)...
January 2017: Acta Oncologica
https://www.readbyqxmd.com/read/27790805/drug-use-among-complete-responders-partial-responders-and-non-responders-in-a-longitudinal-survey-of-nonagenarians-analysis-of-prescription-register-data
#20
Jonas W Wastesson, Lotte Rasmussen, Anna Oksuzyan, Jesper Hallas, Kaare Christensen, Anton Pottegård
PURPOSE: In observational studies, non-response can limit representativity and introduce bias. We aimed to investigate the longitudinal changes in the number of used drugs among complete responders, partial responders, and non-responders in a whole birth cohort of Danish nonagenarians participating in a longitudinal survey. METHODS: We obtained prescription data on all individuals born in 1905 and living in Denmark when the Danish 1905 cohort study was initiated in 1998 (n = 3600) using the Danish National Prescription Registry...
October 28, 2016: Pharmacoepidemiology and Drug Safety
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