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https://www.readbyqxmd.com/read/28499387/evolution-of-the-fourth-stage-of-epidemiologic-transition-in-people-aged-80%C3%A2-years-and-over-population-based-cohort-study-using-electronic-health-records
#1
Nisha C Hazra, Martin Gulliford
BACKGROUND: In the "fourth stage" of epidemiological transition, the distribution of non-communicable diseases is expected to shift to more advanced ages, but age-specific changes beyond 80 years of age have not been reported. METHODS: This study aimed to evaluate demographic and health transitions in a population aged 80 years and over in the United Kingdom from 1990 to 2014, using primary care electronic health records. Epidemiological analysis of chronic morbidities and age-related impairments included a cohort of 299,495 participants, with stratified sampling by five-year age group up to 100 years and over...
May 12, 2017: Population Health Metrics
https://www.readbyqxmd.com/read/28487335/to-treat-or-not-to-treat-anticoagulants-as-secondary-preventives-to-the-oldest-old-with-atrial-fibrillation
#2
Peter Appelros, Bahman Farahmand, Andreas Terént, Signild Åsberg
BACKGROUND AND PURPOSE: Anticoagulant treatment is effective for preventing recurrent ischemic strokes in patients who have atrial fibrillation. This benefit is paid by a small increase of hemorrhages. Anticoagulant-related hemorrhages seem to increase with age, but there are few studies showing whether the benefits of treatment persist in old age. METHODS: For this observational study, 4 different registers were used, among them Riksstroke, the Swedish Stroke Register...
May 9, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28473215/management-of-nonagenarian-patients-with-severe-aortic-stenosis-the-role-of-comorbidity
#3
Eva Bernal, Albert Ariza-Solé, Antoni Bayés-Genís, Francesc Formiga, Pablo Díez-Villanueva, Rafael Romaguera, Hugo González-Saldívar, Manuel Martínez-Sellés
BACKGROUND: The number of nonagenarian patients with aortic stenosis will likely increase due to the ageing population. We assessed the clinical characteristics, management, and outcomes of nonagenarian patients with severe aortic stenosis. METHODS: A total of 177 (117 females and 60 males) consecutive nonagenarian patients from two large contemporary registries were included in this study. Clinical characteristics, comorbidity as assessed by the Charlson Index, clinical management, and outcomes were recorded...
April 12, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28463403/the-impact-of-frailty-status-on-clinical-and-functional-outcomes-after-transcatheter-aortic-valve-replacement-in-nonagenarians-with-severe-aortic-stenosis
#4
Alexis K Okoh, Dhaval Chauhan, Nathan Kang, Nicky Haik, Aurelie Merlo, Mark Cohen, Bruce Haik, Chunguang Chen, Mark J Russo
BACKGROUND: The impact of frailty status on TAVR outcomes in nonagenarians is unknown. The present study aims to investigate the impact of frailty status on procedural outcomes and overall survival in nonagenarians after TAVR. METHODS: A frailty score (FS) was derived by using preoperative grip strength, gait speed, serum albumin, and daily activities. Patients were divided into two groups: Frail (FS ≥ 3/4) and Non-Frail (FS <3/4). Health status was assessed using the 12-item Kansas City Cardiomyopathy Questionnaire (KCCQ)...
May 2, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28457329/physiological-and-operative-severity-score-for-the-enumeration-of-mortality-and-morbidity-and-modified-physiological-and-operative-severity-score-for-the-enumeration-of-mortality-and-morbidity-for-the-mortality-prediction-among-nonagenarians-undergoing-emergency
#5
Yuki Imaoka, Toshiyuki Itamoto, Hideki Nakahara, Koichi Oishi, Yasuhiro Matsugu, Takashi Urushihara
BACKGROUND: The aims of this study were to determine the outcomes of emergency abdominal surgery in patients aged ≥90 y and to analyze the role of Physiological and Operative Severity Score for the enUmeration of Mortality and morbidity (POSSUM) and modified POSSUM in predicting their morbidity and mortality. MATERIALS AND METHODS: Patients aged ≥90 y who underwent emergency abdominal surgery from January 2011 to December 2014 were enrolled in this study. RESULTS: A total of 36 patients satisfied the inclusion criteria...
April 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28450135/transcatheter-aortic-valve-replacement-outcomes-in-nonagenarians-stratified-by-transfemoral-and-transapical-approach
#6
Christian McNeely, Alan Zajarias, Randall Robbs, Stephen Markwell, Christina M Vassileva
BACKGROUND: Survival and other outcomes of nonagenarians undergoing transcatheter aortic valve replacement (TAVR) in the Medicare population are unclear. METHODS: Patients aged 65 years and older who underwent TAVR from November 2011 through 2013 were considered for inclusion. RESULTS: The study consisted of 18,283 patients and 19.3% were aged 90 years or older. Compared with patients younger than 90 years, patients 90 years or older were less likely to have a number of comorbidities, including previous myocardial infarction (17...
June 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28440906/familial-longevity-is-characterized-by-high-circadian-rhythmicity-of-serum-cholesterol-in-healthy-elderly-individuals
#7
Rosa van den Berg, Raymond Noordam, Sander Kooijman, Steffy W M Jansen, Abimbola A Akintola, P Eline Slagboom, Hanno Pijl, Patrick C N Rensen, Nienke R Biermasz, Diana van Heemst
The biological clock, whose function deteriorates with increasing age, determines bodily circadian (i.e. 24h) rhythms, including that of cholesterol metabolism. Dampening of circadian rhythms has been associated with aging and disease. Therefore, we hypothesized that individuals with a familial predisposition for longevity have a higher amplitude circadian serum cholesterol concentration rhythm. The aim of this study was to investigate circadian rhythmicity of serum cholesterol concentrations in offspring of nonagenarian siblings and their partners...
April 2017: Aging Cell
https://www.readbyqxmd.com/read/28422270/characteristics-and-incidence-of-chronic-illness-in-community-dwelling-predominantly-male-u-s-veteran-centenarians
#8
Raya Elfadel Kheirbek, Ali Fokar, Nawar Shara, Leakie K Bell-Wilson, Hans J Moore, Edwin Olsen, Marc R Blackman, Maria D Llorente
OBJECTIVES: To assess the incidence of chronic illness and its effect on veteran centenarians. DESIGN: Retrospective longitudinal cohort study. SETTING: United States Veterans Affairs Corporate Data Warehouse (CDW). PARTICIPANTS: Community-dwelling veterans born between 1910 and 1915 who survived to at least age 80 (N = 86,892; 31,121 octogenarians, 52,420 nonagenarians, 3,351 centenarians). MEASUREMENTS: The Kaplan-Meier method was used to estimate cumulative incidence of chronic conditions according to age group...
April 19, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28382656/surgery-for-chronic-subdural-hematoma-in-nonagenarians-a-scandinavian-population-based-multicenter-study
#9
J Bartek, K Sjåvik, F Ståhl, H Kristiansson, O Solheim, S Gulati, L M Sagberg, P Förander, A S Jakola
OBJECTIVE: Chronic subdural hematoma (cSDH) is a prevalent condition often seen in the elderly, with surgery being the treatment of choice when symptomatic. So far, few have explored the surgical outcomes in patients 90 years or older. The aim of this study was to investigate outcome after cSDH surgery in nonagenarians (≥90 y/o group) compared to younger adult patients (<90 y/o group). MATERIALS: In a Scandinavian population-based cohort we conducted a retrospective review of 1,254 patients undergoing primary burr-hole procedures for cSDH between January 1, 2005 and December 31, 2010 at three neurosurgical centers...
April 6, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28379521/arterial-aging-mediates-the-effect-of-tnf-a-and-ace-polymorphisms-on-mental-health-in-elderly-individuals-insights-from-ikaria-study
#10
George Georgiopoulos, Christina Chrysohoou, Alessandra Errigo, Gianni Pes, Vasiliki Metaxa, Marina Zaromytidou, John Skoumas, Maria Kariori, George Lazaros, Georgia Vogiatzi, Michel Poulain, Dimitris Tousoulis, Christos Pitsavos, Christodoulos Stefanadis
Background: Aging is characterized by an insidious decline in cognitive function. Several genetic and lifestyle factors have been implicated in the increased risk or early onset of dementia We sought to assess the role of tumor necrosis factor (TNF) and angiotensin-converting enzyme (ACE) polymorphisms on the development of impaired mental health in respect to indices ïf arterial aging in nonagenarian individuals. Design: 178 consecutive subjects above 75 years that permanently inhabit in the island of Ikaria, Greece were recruited...
April 3, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28376876/mortality-readmission-and-reoperation-after-hip-fracture-in-nonagenarians
#11
Jeff Chien-Fu Lin, Wen-Miin Liang
BACKGROUND: Osteoporotic hip fractures are associated with high mortality and morbidity in people of advanced age; however, few studies have investigated the complication rates in nonagenarians. In this study, we applied a competing risk analysis to estimate the mortality, readmission, and reoperation rates after surgery for hip fracture among nonagenarians. METHODS: A total of 11,184 nonagenarians (aged ≥ 90) who received surgery for hip fracture during the period 1 January 1997 and 31 December 2010 were selected from Taiwan's National Health Insurance (NHI) database...
April 4, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28373068/stereotactic-body-radiotherapy-for-early-stage-non-small-cell-lung-cancer-in-patients-80-years-and-older-a-multi-center-analysis
#12
Richard J Cassidy, Pretesh R Patel, Xinyan Zhang, Robert H Press, Jeffrey M Switchenko, Rathi N Pillai, Taofeek K Owonikoko, Suresh S Ramalingam, Felix G Fernandez, Seth D Force, Walter J Curran, Kristin A Higgins
BACKGROUND: Stereotactic body radiotherapy (SBRT) is the standard of care for medically inoperable early-stage non-small-cell lung cancer. Despite the limited number of octogenarians and nonagenarians on trials of SBRT, its use is increasingly being offered in these patients, given the aging cancer population, medical fragility, or patient preference. Our purpose was to investigate the efficacy, safety, and survival of patients ≥ 80 years old treated with definitive lung SBRT. METHODS: Patients who underwent SBRT were reviewed from 2009 to 2015 at 4 academic centers...
March 16, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28356210/outcome-after-ruptured-aaa-repair-in-octo-and-nonagenarians-in-sweden-1994-2014
#13
B Sonesson, K Björses, N Dias, R Rylance, K Mani, A Wanhainen, T Resch
OBJECTIVE: To report the outcome after ruptured abdominal aortic aneurysm (rAAA) repair in octo- and nonagenarians from the Swedish Vascular Registry 1994-2014. MATERIAL AND METHODS: 2335 intact AAA (iAAA) and 1538 rAAA were identified in patients aged 80 years and older. Crude, long-term, and relative survival data were analysed using the Kaplan-Meier method. Crude survival was calculated including all deaths. Long-term survival was analysed excluding AAA repair related mortality, defined as death within 90 days of surgery...
March 26, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28342714/higher-uric-acid-serum-levels-are-associated-with-better-muscle-function-in-the-oldest-old-results-from-the-mugello-study
#14
R Molino-Lova, F Sofi, G Pasquini, F Vannetti, S Del Ry, C Vassalle, M Clerici, S Sorbi, C Macchi
BACKGROUND: Sarcopenia is the progressive loss of muscle mass and strength that occurs with advancing age and plays a pivotal role in the causal pathway leading to frailty, disability and, eventually, to death among older persons. As oxidative damage of muscle proteins has been shown to be a relevant contributory factor, in this study we hypothesized that uric acid (UA), a powerful endogenous antioxidant, might exert a protective effect on muscle function in the oldest old and we tested our hypothesis in a group of nonagenarians who participated in the Mugello Study...
March 22, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28340313/linkage-between-mitochondrial-genome-alterations-telomere-length-and-aging-population
#15
Egija Zole, Krista Zadinane, Liana Pliss, Renate Ranka
We studied telomere length (TL) and mitochondrial DNA (mtDNA) copy number variations in individuals from Latvian Caucasian population in different age groups. We showed a positive correlation between TL and mtDNA copy number in individuals of up to 90 years of age; however, this correlation was not observed in the 90-100 years age group. While TL shortened with age and mtDNA content decreased with increasing age, in this study it was observed that mtDNA copy number in nonagenarians was slightly higher than in the 60-89 years age group...
March 24, 2017: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
https://www.readbyqxmd.com/read/28330822/long-term-survival-of-patients-aged-80-years-or-older-treated-with-radical-prostatectomy-for-prostate-cancer
#16
P Dell'Oglio, E Zaffuto, K Boehm, V Trudeau, A Larcher, Z Tian, M Moschini, S F Shariat, M Graefen, F Saad, U Capitanio, A Briganti, F Montorsi, P I Karakiewicz
BACKGROUND: Radical prostatectomy (RP) is the gold standard for clinically localized prostate cancer (PCa) patients with life expectancy (LE) of at least 10 years. We examined long-term survival of men aged 80 years or older treated with RP and we attempted to identify criteria based on age and comorbidities that could predict survival of at least 10 years after RP, to identify those that might be considered for RP. PATIENTS AND METHODS: In Surveillance Epidemiology and End Results (SEER)-Medicare-linked database, we identified 234 octo- and nonagenarians with clinical T1, T2 or T3 PCa treated with RP between 1991 and 2009...
March 10, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28329171/body-mass-index-and-waist-circumference-as-predictors-of-disability-in-nonagenarians-the-vitality-90-study
#17
Inna Lisko, Kristina Tiainen, Jani Raitanen, Juulia Jylhävä, Mikko Hurme, Antti Hervonen, Marja Jylhä, Sari Stenholm
Background: Only scarce data exist on the association between obesity and disability in the oldest old. The purpose of this prospective study is to examine if body mass index and waist circumference (WC) are associated with incident mobility and activities of daily living (ADL) disability in nonagenarians. Methods: We used longitudinal data from the Vitality 90+ Study, which is a population-based study conducted at the area of Tampere, Finland. Altogether 291 women and 134 men, aged 90-91 years, had measured data on body mass index and/or WC and did not have self-reported mobility or ADL disability at baseline...
March 14, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28323333/a-longitudinal-study-of-the-mini-mental-state-examination-in-late-nonagenarians-and-its-relationship-with-dementia-mortality-and-education
#18
Johan Skoog, Kristoffer Backman, Mats Ribbe, Hanna Falk, Pia Gudmundsson, Valgeir Thorvaldsson, Anne Borjesson-Hanson, Svante Ostling, Boo Johansson, Ingmar Skoog
OBJECTIVES: To examine level of and change in cognitive status using the Mini-Mental State Examination (MMSE) in relation to dementia, mortality, education, and sex in late nonagenarians. DESIGN: Three-year longitudinal study with examinations at ages 97, 99, and 100. SETTING: Trained psychiatric research nurses examined participants at their place of living. PARTICIPANTS: A representative population-based sample of 97-year-old Swedes (N = 591; 107 men, 484 women) living in Gothenburg, Sweden...
March 21, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28320990/comorbidities-and-complications-in-nonagenarians-undergoing-coronary-angiography-and-intervention
#19
Mohamed Gayed, Nour Yadak, Waad Qamhia, Yunis Daralammouri, Marc-Alexander Ohlow
Elderly people represent the fastest growing portion of cardiovascular patients. We aimed to analyze the clinical presentation, risk factors, co-morbidities, complications, and mortality in patients 90 years or more who underwent coronary angiography and intervention.We retrospectively studied 108 (0.25% of 43,385) consecutive patients ≥ 90 years undergoing cardiac catheterization and/or intervention in a tertiary specialist hospital between 2003 and 2014.Most patients (68.5%) were introduced on an emergency basis, especially with acute coronary syndrome (ACS) (63...
April 6, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28289477/obesity-accelerates-epigenetic-aging-in-middle-aged-but-not-in-elderly-individuals
#20
Tapio Nevalainen, Laura Kananen, Saara Marttila, Juulia Jylhävä, Nina Mononen, Mika Kähönen, Olli T Raitakari, Antti Hervonen, Marja Jylhä, Terho Lehtimäki, Mikko Hurme
BACKGROUND: Human aging is associated with profound changes in one of the major epigenetic mechanisms, DNA methylation. Some of these changes occur in a clock-like fashion, i.e., correlating with the calendar age of an individual, thus providing a new aging biomarker. Some reports have identified factors associated with the acceleration of the epigenetic age. However, it is also important to analyze the temporal changes in the epigenetic age, i.e., the duration of the observed acceleration, and the effects of the possible therapeutic and lifestyle modifications...
2017: Clinical Epigenetics
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