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https://www.readbyqxmd.com/read/29775123/do-we-know-what-to-do-with-our-nonagenarian-and-centenarian-patients-with-metastatic-colorectal-cancer-mcrc-results-from-the-south-australian-mcrc-registry
#1
Gonzalo Tapia Rico, Christos Karapetis, Amanda R Townsend, Cynthia Piantadosi, Rob Padbury, Amitesh Roy, Guy Maddern, James Moore, Scott Carruthers, David Roder, Timothy J Price
No abstract text is available yet for this article.
May 18, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29717755/mediterranean-diet-food-consumption-and-risk-of-late-life-depression-the-mugello-study
#2
G Pagliai, F Sofi, F Vannetti, S Caiani, G Pasquini, R Molino Lova, F Cecchi, S Sorbi, C Macchi
OBJECTIVES: To investigate eating habits and adherence to Mediterranean Diet (MD) in relation to the risk of depression in a cohort of nonagenarians enrolled within the Mugello Study, an epidemiological study aimed at investigating both clinically relevant geriatric items and various health issues, including those related to nutritional status. DESIGN: Cross-sectional study. SETTING: Homes and nursing homes in the Mugello area, Florence, Italy...
2018: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29712948/g-395a-polymorphism-in-the-promoter-region-of-the-klotho-gene-associates-with-frailty-among-the-oldest-old
#3
Qiukui Hao, Yuting Wang, Xiang Ding, Biao Dong, Ming Yang, Birong Dong, Yuquan Wei
Frailty is characterized by a decline in physiological reserve and increased vulnerability. Previous studies have shown that KLOTHO (KL) plays a protective role in several age-related diseases. We hypothesize a probable protective effect of KL on frailty in the elderly population and included a cohort of Chinese nonagenarians and centenarians for our study. This study is part of a cross-sectional study and secondary analysis of the Project of Longevity and Aging in Dujiangyan (PLAD) study, which was conducted in Southwest China...
April 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29667314/the-diary-of-a-nonagenarian-centenarian-woman-with-dementia-memory-loss-life-changes-and-community-care-in-japan
#4
Sayuri Suwa, Saori Otani, Mayuko Tsujimura, Kotoko Nogawa, Yoko Shiya
AIM: This study aimed to explore the experiences and thoughts of a nonagenarian-centenarian woman with dementia living alone, through detailed analysis of her unsolicited diary. DATA SOURCE: After receiving consent from Aki (a pseudonym), her family and caregivers, copies of her diaries, hand-written in Japanese, were provided for analysis. METHODS: The content of the diaries was broadly organized into themes and qualitative content analysis carried out for each theme along a sequential timeline...
April 2018: International Journal of Nursing Practice
https://www.readbyqxmd.com/read/29662833/short-term-outcomes-following-hepatectomy-in-elderly-patients-with-hepatocellular-carcinoma-an-analysis-of-10-805-septuagenarians-and-2-381-octo-and-nonagenarians-in-japan
#5
Hiroko Okinaga, Hideo Yasunaga, Kiyoshi Hasegawa, Kiyohide Fushimi, Norihiro Kokudo
Background: As the population is aging, the indication for hepatocellular carcinoma (HCC) resection in patients aged over 80 years will increase. Japan is facing the most aging society worldwide. We examined the safety of hepatectomy in octogenarians and nonagenarians using large-scale data from the Diagnosis Procedure Combination database, a national administrative database in Japan. Method: We conducted a survey to collect data for all inpatients from 2007 and 2012...
March 2018: Liver Cancer
https://www.readbyqxmd.com/read/29662505/comparison-of-in-hospital-outcomes-between-octogenarians-and-nonagenarians-undergoing-transcatheter-aortic-valve-replacement-a-propensity-matched-analysis
#6
Rajkumar Doshi, Vaibhav Patel, Priyank Shah
Background: Aortic valve stenosis (AS) is very common in the elderly patients above 80 years. Transcatheter aortic valve replacement (TAVR) in such patients is being increasingly performed. This study sought to assess in-hospital outcome differences between octogenarians and nonagenarians and predictors of mortality in nonagenarians undergoing TAVR with severe AS. Method: The study population was derived from the National Inpatient Sample (NIS) for the years 2012-2014 using ICD-9 CM procedure codes 35...
February 2018: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29656837/long-term-care-status-in-centenarians-and-younger-cohorts-of-oldest-old-in-the-last-6-years-of-life-trajectories-and-potential-mechanisms
#7
Paul Gellert, Simon Eggert, Christine Zwillich, Stefan Hörter, Adelheid Kuhlmey, Dagmar Dräger
OBJECTIVES: A large proportion of the oldest old and centenarians live in long-term care facilities. Although there may be distinct care patterns in centenarians compared with other cohorts of oldest old, the exact development concerning prevalence, length of stay, and factors that are associated with long-term care status in the last years before death is unknown. DESIGN: Longitudinal analyses of health insurance data across 6 years before death. SETTING AND PARTICIPANTS: In all, 1398 institutionalized and noninstitutionalized oldest old [deceased at 80-89 (octogenarians), 90-99 (nonagenarians), or over 100 years of age (centenarians)] from Germany were included...
April 13, 2018: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29628213/-progressive-elevation-of-ca-19-9-tumour-marker-in-a-nonagenarian-with-advanced-idiopathic-pulmonary-fibrosis
#8
Vicent Romero Estarlich, Nicolas María González-Senac, Daiana Yulissa Peña Lora, María Teresa Vidán Astiz, José Antonio Serra Rexach
No abstract text is available yet for this article.
April 5, 2018: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/29627110/comparison-of-outcomes-of-transfemoral-aortic-valve-implantation-in-patients-90-with-those-90-years-of-age
#9
Jeroen Vendrik, Martijn S van Mourik, Floortje van Kesteren, Marieke J Henstra, Jan J Piek, Jose P S Henriques, Joanna J Wykrzykowska, Robbert J de Winter, M Marije Vis, Karel T Koch, Jan Baan
In patients who underwent transcatheter aortic valve implantation (TAVI), postoperative mortality risk is commonly assessed with risk scores such as the Society of Thoracic Surgeons-Postoperative Risk of Mortality (STS-PROM) and EuroSCORE II, in which age plays a dominant role. However, we reason that in the naturally selected oldest-old patients (nonagenarians), this may not be completely justified and that therefore age should play a minor role in decision-making. The objective of this study was to compare procedural outcome and mid-term mortality of transfemoral (TF)-TAVI patients aged ≥90 years with patients aged <90 years...
March 15, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29619274/evaluating-postoperative-complications-and-outcomes-of-orthopedic-fracture-repair-in-nonagenarian-patients
#10
Kyle A Scarano, Frances H Philp, Edward R Westrick, Gregory T Altman, Daniel T Altman
Introduction: The United States and the world are currently experiencing a tremendous growth in the elderly population. Moreover, individuals surpassing the ages of 80 and 90 are also continuing to increase. As this unique division of society expands, it is critical that the medical community best understands how to assess, diagnose, and treat this population. The purpose of this study was to analyze morbidity, mortality, and overall outcome of patients aged 90 years and older after orthopedic surgical fracture repair...
2018: Geriatric Orthopaedic Surgery & Rehabilitation
https://www.readbyqxmd.com/read/29596573/longevity-around-the-turn-of-the-20th-century-life-long-sustained-survival-advantage-for-parents-of-today-s-nonagenarians
#11
Niels van den Berg, Mar Rodriguez-Girondo, Anton J M de Craen, Jeanine J Houwing-Duistermaat, Marian Beekman, P Eline Slagboom
Members of longevous families live longer than individuals from similar birth cohorts and delay/escape age related diseases. Insight into this familial component of longevity can provide important knowledge about mechanisms protecting against age-related diseases. This familial component of longevity was studied in the Leiden Longevity Study which consists of 944 longevous siblings (participants), their parents (N=842), siblings (N=2302), and spouses (N=809). Family longevity scores were estimated to explore whether human longevity is transmitted preferentially through the maternal or paternal line...
March 27, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29577582/the-genetic-component-of-human-longevity-new-insights-from-the-analysis-of-pathway-based-snp-snp-interactions
#12
Serena Dato, Mette Soerensen, Francesco De Rango, Giuseppina Rose, Kaare Christensen, Lene Christiansen, Giuseppe Passarino
In human longevity studies, single nucleotide polymorphism (SNP) analysis identified a large number of genetic variants with small effects, yet not easily replicable in different populations. New insights may come from the combined analysis of different SNPs, especially when grouped by metabolic pathway. We applied this approach to study the joint effect on longevity of SNPs belonging to three candidate pathways, the insulin/insulin-like growth factor signalling (IIS), DNA repair and pro/antioxidant. We analysed data from 1,058 tagging SNPs in 140 genes, collected in 1825 subjects (1,089 unrelated nonagenarians from the Danish 1905 Birth Cohort Study and 736 Danish controls aged 46-55 years) for evaluating synergic interactions by SNPsyn...
March 25, 2018: Aging Cell
https://www.readbyqxmd.com/read/29566380/resting-heart-rate-is-not-associated-with-cognitive-function
#13
Mette Wod, Magnus Thorsten Jensen, Søren Galatius, Jacob B Hjelmborg, Gorm B Jensen, Kaare Christensen
AIMS: In order to examine the hypothesis that elevated resting heart rate (RHR) is associated with impaired cognitive score, we investigated the relationship between RHR and cognitive score in middle-aged, elderly and old Danish subjects from the general population. METHODS: Composite cognitive scores derived from the result of 5 age-sensitive cognitive tests for a total of 7,002 individuals (Middle-aged Danish twin: n = 4,132, elderly Danish twins: n = 2,104 and Danish nonagenarian: n = 766) divided according to RHR and compared using linear regression models adjusted for sex, age, previous heart conditions and hypertension...
March 22, 2018: Neuroepidemiology
https://www.readbyqxmd.com/read/29566272/association-between-lifetime-risk-of-atrial-fibrillation-and-mortality-in-the-oldest-old
#14
Raya Elfadel Kheirbek, Ali Fokar, Hans J Moore, Nawar Shara, Rami Doukky, Ross D Fletcher
BACKGROUND: Age is the strongest predictor of atrial fibrillation (AF), yet little is known about AF incidence in the oldest old. HYPOTHESIS: AF incidence declines after age 90, and morbidity is compressed into a brief period at the end of life. METHODS: In this retrospective, longitudinal cohort study of patients (born 1905-1935), we examined cumulative lifetime incidence of AF and its impact on mortality. Data included records from 1,062,610 octogenarians; 317,161 nonagenarians; and 3,572 centenarians...
March 22, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29487750/transcatheter-aortic-valve-implantation-in-a-nonagenarian-with-aortic-aneurysm-futility-or-utility
#15
Evelyn Fennelly, Marcus Lee, Mark Da Costa, Sherif Sultan, Faisal Sharif, Darren Mylotte
Transcatheter aortic valve implantation (TAVI) has emerged as the standard of care for older patients with symptomatic severe aortic stenosis (AS) at high or excessive operative risk. There remain patients that are of such considerable risk that even TAVI can be futile. Such patients present ethical conundrums for institutional heart teams. Herein we present a case of a 90-year-old female patient with symptomatic severe AS and significant comorbidities including diffuse peripheral vascular disease and a large ascending aortic aneurysm...
2018: Case Reports in Cardiology
https://www.readbyqxmd.com/read/29485516/the-impact-of-advanced-age-on-the-outcomes-of-primary-total-hip-and-knee-arthroplasty-for-osteoarthritis-a-systematic-review
#16
Benjamin P d'S Murphy, Michelle M Dowsey, Peter F M Choong
BACKGROUND: Elective total hip arthroplasty (THA) and total knee arthroplasty (TKA) are effective options for the management of osteoarthritis that has not responded to conservative therapy, and they are increasing in utilization worldwide. Therefore, we sought to investigate how older age influences the outcomes of THA and TKA through a review of the current literature. METHODS: The Embase and MEDLINE databases were examined for relevant studies that assessed the role of older age in determining the outcomes of THA and TKA...
February 2018: JBJS Reviews
https://www.readbyqxmd.com/read/29471390/hybrid-treatment-for-a-type-2-kommerell-s-aneurysm-in-a-nonagenarian
#17
Vasileios D Tzilalis, Ioannis G Kantounakis, Konstantinos M Pirgakis, Antonios Ch Chalkias
No abstract text is available yet for this article.
February 19, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29467961/the-outcomes-and-prognostic-factors-of-acute-respiratory-failure-in-the-patients-90-years-old-and-over
#18
Wan-Ling Chen, Chin-Ming Chen, Shu-Chen Kung, Ching-Min Wang, Chih-Cheng Lai, Chien-Ming Chao
This retrospective cohort study investigated the outcomes and prognostic factors in nonagenarians (patients 90 years old or older) with acute respiratory failure. Between 2006 and 2016, all nonagenarians with acute respiratory failure requiring invasive mechanical ventilation (MV) were enrolled. Outcomes including in-hospital mortality and ventilator dependency were measured. A total of 173 nonagenarians with acute respiratory failure were admitted to the intensive care unit (ICU). A total of 56 patients died during the hospital stay and the rate of in-hospital mortality was 32...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29455295/is-extreme-climate-or-moderate-climate-more-conducive-to-longevity-in-china
#19
Yi Huang, Mark Rosenberg, Yingli Wang
Climate is closely related to human longevity. In China, there are many climate types. According to national population censuses from 1982 to 2000, most provinces with a high ratio of centenarians are located in western and northwestern China far from the sea; these areas are characterized by a dry, cold climate, very high altitude, very high daily temperature range, strong winds, and partial hypoxia. Meanwhile, provinces with a high ratio of nonagenarians from 1982 to 2000 are located in southern China near the sea...
February 17, 2018: International Journal of Biometeorology
https://www.readbyqxmd.com/read/29426609/factors-influencing-survival-following-hip-fracture-among-octogenarians-and-nonagenarians-in-the-united-states
#20
Steven L Bokshan, Stephen E Marcaccio, Travis D Blood, Roman A Hayda
INTRODUCTION: Hip fractures account for a significant disease burden in the Unites States. With an aging population, this disease burden is expected to increase in the upcoming decades. MATERIALS AND METHODS: This represents a retrospective cohort study to assess mortality following hip fracture in the octogenarian and nonagenarian populations. Odds ratios for postoperative mortality were constructed using normalized patients from United States Social Security death tables...
March 2018: Injury
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