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Pint study

Landon Oakes, Nitin Muralidharan, Adam P Cohn, Cary L Pint
The effectiveness of using catalyst nanoparticles to reduce the overpotential and energy efficiency of lithium-oxygen (or lithium-air) batteries (LOBs) is usually attributed to the inherent catalytic properties of individual nanoparticles. Here, we demonstrate that the morphology of the catalyst layer is equally important in maintaining integrity of the catalyst coating during product formation in LOBs. We demonstrate this by comparing the performance of smooth, conformal coated Mn2O3 catalyst nanoparticles prepared by electric field-assisted deposition, and more irregular coatings using conventional film assembly techniques both on three-dimensional mesh substrates...
December 9, 2016: Nanotechnology
Dandan Ma, Jing Zheng, Pinting Tang, Weijian Xu, Zhihe Qing, Sheng Yang, Jishan Li, Ronghua Yang
Hypoxia is considered to contribute to pathophysiology in various cells and tissues, a clear understanding about the relationship between hypoxia and intracellular acidification will help to elucidate the complex mechanism of glycolysis under hypoxia. However, current researches are mainly focused on overexpressing of intracellular reductases accelerated by hypoxia, and the investigations focusing on the relationship between hypoxic degree and intracellular acidification remained to be explored. For this vacuity, we report herein a new activatable nanoprobe for sensing pH change under different degrees of hypoxia by surface enhanced Raman spectroscopy (SERS)...
November 1, 2016: Analytical Chemistry
Hyun-Jin Kim, Jin-Young Min, Kyoung-Bok Min
OBJECTIVES: Central obesity plays a major role in the development of many chronic diseases, including cardiovascular disease and cancer. Chronic stress may be involved in the pathophysiology of central obesity. Although several large-scale genome-wide association studies have reported susceptibility genes for central adiposity, the effects of interactions between genes and psychosocial stress on central adiposity have rarely been examined. A recent study focusing on Caucasians discovered the novel gene early B-cell factor 1 (EBF1), which was associated with central obesity-related traits via interactions with stress levels...
September 2016: Journal of Preventive Medicine and Public Health, Yebang Ŭihakhoe Chi
Jean-Sebastien Provost, Simona M Brambati, Marianne Chapleau, Maximiliano A Wilson
Cognitive and computational models of reading aloud agree on the existence of two procedures for reading. Pseudowords (e.g., atendier) are correctly read through subword processes only while exception words (e.g., pint) are only correctly read via whole-words processes. Regular words can be correctly read by means of either way. Previous behavioral studies showed that older adults relied more on whole-word processing for reading. The aim of the present fMRI study was to verify whether this larger whole-word reliance for reading in older adults was reflected by changes in the pattern of brain activation...
September 17, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Keith Share, Adam P Cohn, Rachel Carter, Bridget Rogers, Cary L Pint
Potassium is an earth abundant alternative to lithium for rechargeable batteries, but a critical limitation in potassium ion battery anodes is the low capacity of KC8 graphite intercalation compounds in comparison to conventional LiC6. Here we demonstrate that nitrogen doping of few-layered graphene can increase the storage capacity of potassium from a theoretical maximum of 278 mAh/g in graphite to over 350 mAh/g, competitive with anode capacity in commercial lithium-ion batteries and the highest reported anode capacity so far for potassium ion batteries...
October 9, 2016: ACS Nano
Keith Share, Adam P Cohn, Rachel E Carter, Cary L Pint
Recently emerging potassium ion (K-ion) batteries offer a lower-cost alternative to lithium-ion batteries while enabling comparably high storage capacity. Here, we leverage the strong Raman spectroscopic response of few-layered graphene to provide the first insight into the electrochemical staging sequence for K(+) ions in graphitic carbons. Our analysis reveals the signature of a dilute stage I compound that precedes formation of ordered intercalation compounds transitioning from stage VI (KC72), stage II (KC24), and stage I (KC8) and correlates electrochemical responses to the stage formation...
September 15, 2016: Nanoscale
Lars Barquist, Alexander J Westermann, Jörg Vogel
Infection is a complicated balance, with both pathogen and host struggling to tilt the result in their favour. Bacterial infection biology has relied on forward genetics for many of its advances, defining phenotype in terms of replication in model systems. However, many known virulence factors fail to produce robust phenotypes, particularly in the systems most amenable to genetic manipulation, such as cell-culture models. This has particularly been limiting for the study of the bacterial regulatory small RNAs (sRNAs) in infection...
November 5, 2016: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
L Manco, H Dias, M Muc, C Padez
BACKGROUND/OBJECTIVES: Several studies reported associations of the lactase gene (LCT) polymorphism -13910C>T (rs4988235) with obesity-related variables and obesity in adults. This study aimed to replicate previously reported associations in a population sample of Portuguese young adults. SUBJECTS/METHODS: We genotyped 447 subjects from central and northern regions of Portugal (mean age 20.81±4.24 years) for the lactase variant -13910C>T (rs4988235), using TaqMan probes...
August 31, 2016: European Journal of Clinical Nutrition
Hyun-Seung Yoo, Young-Ho Cho, Young-Soo Byun, Min-Guek Kim
PURPOSE: The purpose of this study was to evaluate whether we have to stop the antiplatelet agents prior to hemiarthroplasty surgery in patients with displaced femur neck fractures to reduce postoperative complications. MATERIALS AND METHODS: We enrolled forty-three patients with displaced femur neck fractures who were treated by bipolar hemiarthroplasty and were taking antiplatelet agents. Group I included 21 patients who discontinued antiplatelet agents and had delayed operations at an average 5...
September 2015: Hip & Pelvis
Sergio Leonardi, Renato D Lopes, Ph Gabriel Steg, Freddy Abnousi, Alberto Menozzi, Jayne Prats, Stacey Mangum, Matthew Wilson, Meredith Todd, Gregg W Stone, C Michael Gibson, Christian W Hamm, Matthew J Price, Harvey D White, Robert A Harrington, Deepak L Bhatt, Kenneth W Mahaffey
AIMS: The purpose of this study was to test whether different results between Cangrelor versus standard therapy to acHieve optimal Management of Platelet InhibitiON (CHAMPION) PCI/PLATFORM and PHOENIX trials are due in part to different definitions of percutaneous coronary intervention (PCI)-related myocardial infarction (MI). METHODS AND RESULTS: In patients with acute coronary syndrome (ACS), the definition of MI was identical in CHAMPION PCI and PLATFORM and did not require an assessment of baseline cardiac biomarker status, while in PHOENIX specific MI criteria were associated with different patient presentations...
August 2, 2016: European Heart Journal. Acute Cardiovascular Care
Xiaoyan Yang, Yujiao Fu, Qiong Zhan, Sha Huang, Luo Zhou, Hongyu Long, Pinting Zhou, Chaorong Liu, Yayu Chen, Lili Long, Bo Xiao
PURPOSE: To study the clinical characteristics of patients with game-induced seizures in the Chinese population. METHOD: We assessed 51 patients with various game-induced epileptic seizures. Based on whether they had spontaneous seizures, these 51 patients were classified as two groups. Twenty-seven patients who had both game-induced and spontaneous seizures were referred to as Group I, whereas twenty-four patients that had experienced seizures exclusively while playing specific games were assigned to Group II...
October 2016: Seizure: the Journal of the British Epilepsy Association
Alice W Lee, Ashley Bomkamp, Elisa V Bandera, Allan Jensen, Susan J Ramus, Marc T Goodman, Mary Anne Rossing, Francesmary Modugno, Kirsten B Moysich, Jenny Chang-Claude, Anja Rudolph, Aleksandra Gentry-Maharaj, Kathryn L Terry, Simon A Gayther, Daniel W Cramer, Jennifer A Doherty, Joellen M Schildkraut, Susanne K Kjaer, Roberta B Ness, Usha Menon, Andrew Berchuck, Bhramar Mukherjee, Lynda Roman, Paul D Pharoah, Georgia Chenevix-Trench, Sara Olson, Estrid Hogdall, Anna H Wu, Malcolm C Pike, Daniel O Stram, Celeste Leigh Pearce
Menopausal estrogen-alone therapy (ET) is a well-established risk factor for serous and endometrioid ovarian cancer. Genetics also plays a role in ovarian cancer, which is partly attributable to 18 confirmed ovarian cancer susceptibility loci identified by genome-wide association studies. The interplay among these loci, ET use, and ovarian cancer risk has yet to be evaluated. We analyzed data from 1,414 serous cases, 337 endometrioid cases, and 4,051 controls across 10 case-control studies participating in the Ovarian Cancer Association Consortium (OCAC)...
July 15, 2016: International Journal of Cancer. Journal International du Cancer
David A Hinds, Kimberly E Barnholt, Ruben A Mesa, Amy K Kiefer, Chuong B Do, Nicholas Eriksson, Joanna L Mountain, Uta Francke, Joyce Y Tung, Huong Marie Nguyen, Haiyu Zhang, Linda Gojenola, James L Zehnder, Jason Gotlib
We conducted a genome-wide association study (GWAS) to identify novel predisposition alleles associated with Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs) and JAK2 V617F clonal hematopoiesis in the general population. We recruited a web-based cohort of 726 individuals with polycythemia vera, essential thrombocythemia, and myelofibrosis and 252 637 population controls unselected for hematologic phenotypes. Using a single-nucleotide polymorphism (SNP) array platform with custom probes for the JAK2 V617F mutation (V617F), we identified 497 individuals (0...
August 25, 2016: Blood
Marcin Cwynar, Jerzy Gąsowski, Anna Głuszewska, Jarosław Królczyk, Henryk Bartoń, Agnieszka Słowik, Tomasz Grodzicki
INTRODUCTION: Although recently a matter of epidemiologic controversy, sodium overload and its interaction with genetic factors predispose to hypertension and related target organ complications. METHODS: In 131 (66 male) treated hypertensives, we measured peripheral and central arterial pressures and pulse wave augmentation indexes (AIx(P), AIx(C1), AIx(C2)), pulse wave velocity (PWV), daily urinary sodium excretion and did genetic studies of AGTR1 A1166C and AGTR2 G1675A polymorphisms...
April 2016: Journal of the Renin-angiotensin-aldosterone System: JRAAS
Li Tao, Xiaobo Sheng, Lei Zhang, Weidong Li, Zhonghong Wei, Pinting Zhu, Feng Zhang, Aiyun Wang, James R Woodgett, Yin Lu
Xanthatin, a xanthanolide sesquiterpene lactone isolated from Xanthium strumarium L. (Asteraceae), has prominent anti-tumor activity. Initial mechanism of action studies suggested xanthatin triggered activation of Wnt/β-catenin. We examined the effects of xanthatin on signaling pathways in A459 lung cancer cells and mouse embryonic fibroblasts to ascertain requirements for xanthatin-induced cell death and tumor growth in xenografts. Genetic inactivation of GSK-3β, but not the related isoform GSK-3α, compromised xanthatin cytotoxicity while inactivation of β-catenin enhanced xanthatin-mediated cell death...
September 1, 2016: Biochemical Pharmacology
Kelly A Hirko, Renée T Fortner, Susan E Hankinson, Tianying Wu, A Heather Eliassen
Findings from epidemiologic studies of oxidative stress biomarkers and breast cancer have been mixed, although no studies have focused on estrogen receptor-negative (ER-) tumors which may be more strongly associated with oxidative stress. We examined prediagnostic plasma fluorescent oxidation products (FlOP), a global biomarker of oxidative stress, and risk of ER- breast cancer in a nested case-control study in the Nurses' Health Study and Nurses' Health Study II. ER- breast cancer cases (n = 355) were matched to 355 controls on age, month/time of day of blood collection, fasting status, menopausal status, and menopausal hormone use...
July 2016: Breast Cancer Research and Treatment
Jessica L Petrick, Neal D Freedman, Jane Demuth, Baiyu Yang, Stephen K Van Den Eeden, Lawrence S Engel, Katherine A McGlynn
OBJECTIVE: Obesity and diabetes have been associated with liver cancer. However, recent US-based studies have suggested a lack of association between obesity and liver cancer among blacks and women. METHODS: We conducted a nested case-control study within the Multiphasic Health Checkup (MHC) cohort of Kaiser Permanente Northern California (KPNC) members. Liver cancer was diagnosed using the KPNC Cancer Registry. Detailed self-administered questionnaires and a standardized examination that included measurement of height and weight and a 1-h glucose tolerance test were completed prior to diagnosis of liver cancer for cases (n=450) and matched controls (4489)...
June 2016: Cancer Epidemiology
Eric Lavigne, Abdool S Yasseen, David M Stieb, Perry Hystad, Aaron van Donkelaar, Randall V Martin, Jeffrey R Brook, Daniel L Crouse, Richard T Burnett, Hong Chen, Scott Weichenthal, Markey Johnson, Paul J Villeneuve, Mark Walker
BACKGROUND: Prenatal exposure to ambient air pollution has been associated with adverse birth outcomes, but the potential modifying effect of maternal comorbidities remains understudied. Our objective was to investigate whether associations between prenatal air pollution exposures and birth outcomes differ by maternal comorbidities. METHODS: A total of 818,400 singleton live births were identified in the province of Ontario, Canada from 2005 to 2012. We assigned exposures to fine particulate matter (PM2...
July 2016: Environmental Research
Gabriele Crimi, Sergio Leonardi, Francesco Costa, Marianna Adamo, Sara Ariotti, Marco Valgimigli
AIM: Chronic kidney disease (CKD) is a powerful predictor of major cardiovascular events and stent thrombosis (ST) in patients undergoing percutaneous coronary interventions (PCI). No randomized data are available to compare, and guide the selection of type of stent between bare metal (BMS) or drug eluting stent (DES) in this population. METHODS AND RESULTS: We performed a post-hoc analysis of the PROlonging Dual antiplatelet treatment after Grading stent-induced Intimal hyperplasia studY (PRODIGY) trial, in which stable or unstable patients with coronary artery disease undergoing PCI were randomized 1:1:1:1 to receive BMS, paclitaxel- (PES), zotarolimus- (ZES-S), or everolimus- (EES) eluting stent...
June 1, 2016: International Journal of Cardiology
Cyrille Orset, Benoit Haelewyn, Stuart M Allan, Saema Ansar, Francesco Campos, Tae Hee Cho, Anne Durand, Mohamad El Amki, Marc Fatar, Isaac Garcia-Yébenes, Maxime Gauberti, Saskia Grudzenski, Ignacio Lizasoain, Eng Lo, Richard Macrez, Isabelle Margaill, Samaneh Maysami, Stephen Meairs, Norbert Nighoghossian, Josune Orbe, Jose Antonio Paramo, Jean-Jacques Parienti, Nancy J Rothwell, Marina Rubio, Christian Waeber, Alan R Young, Emmanuel Touzé, Denis Vivien
BACKGROUND AND PURPOSE: The debate over the fact that experimental drugs proposed for the treatment of stroke fail in the translation to the clinical situation has attracted considerable attention in the literature. In this context, we present a retrospective pooled analysis of a large data set from preclinical studies, to examine the effects of early versus late administration of intravenous recombinant tissue-type plasminogen activator. METHODS: We collected data from 26 individual studies from 9 international centers (13 researchers; 716 animals) that compared recombinant tissue-type plasminogen activator with controls, in a unique mouse model of thromboembolic stroke induced by an in situ injection of thrombin into the middle cerebral artery...
May 2016: Stroke; a Journal of Cerebral Circulation
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