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https://www.readbyqxmd.com/read/28803046/design-synthesis-and-biological-evaluation-of-novel-pyrazolochalcones-as-potential-modulators-of-pi3k-akt-mtor-pathway-and-inducers-of-apoptosis-in-breast-cancer-cells
#1
Anver Basha Shaik, Garikapati Koteswara Rao, G Bharath Kumar, Nibeditha Patel, Vangala Santhosh Reddy, Irfan Khan, Sunitha Rani Routhu, C Ganesh Kumar, Immadi Veena, Kunta Chandra Shekar, Madan Barkume, Shailesh Jadhav, Aarti Juvekar, Jyoti Kode, Manika Pal-Bhadra, Ahmed Kamal
Cancer has been established as the "Emperor of all maladies". In recent years, medicinal chemistry has focused on identifying novel anti-cancer compounds; though discovery of these compounds appears to be a herculean task. In present study, we synthesized forty pyrazolochalcone conjugates and explored their cytotoxic activity against a panel of sixty cancer cell lines. Fifteen conjugates of the series showed excellent growth inhibition (13b-e, 13h-j, 14c-d, 15 a, 15 c-d, 16b, 16d and 18f; GI50 for MCF-7: 0...
July 25, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28767265/professors-principals-and-textbooks-from-the-midwifery-school-in-zadar
#2
REVIEW
Jovan Maksimović, Marko Maksimović
Midwifery in Dalmatia was highly undeveloped at the beginning of the XIX century. The health report from 1813 suggested that there were only 48 midwives in the whole province, and none of them with a degree from the midwifery school. After abolishing the Central Schools ("Ecoles Centrales"), which were founded at the time of French reign, and which had the university range, the professors who stayed in Zadar continued their work and teaching in the Midwifery School, which was founded in 1820 according to the decision made by Emperor Franz I, and started working in 1821...
June 2017: Acta Medico-historica Adriatica: AMHA
https://www.readbyqxmd.com/read/28766532/-the-grand-prince-g-a-romanov-and-the-diagnostic-capabilities-of-xix-century-medicine
#3
A V Kovalev, Yu A Molin
This article is devoted to the medical aspects of the biography of the Grand Prince Georgiy Romanov, the younger brother of Nikolas II, the Russian Emperor. It reports the results of the analysis of the formerly unpublished documents stored in the funds of the Russian State Historical Archive (RGIA). The authors present the data characterizing the level of medical care provided to the patients in Russia of that time. In addition, they describe the specific morphological patterns of pulmonary tuberculosis which affected the Crown Prince and became the cause of his death...
2017: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/28736593/successful-treatment-of-achilles-tendinopathy-with-electroacupuncture-two-cases
#4
Matthew Kendall Hawks
Background: Achilles tendinopathy is a common injury for active patient populations and is challenging to treat. Acupuncture tendon-based therapy was first described in the Yellow Emperor's Classic of Internal Medicine. In modern times, specific techniques have been described poorly in the literature. The aim of this case report is to describe a new technique of acupuncture for the treatment of Achilles tendinopathy and provide 2 illustrative cases. Cases: Treatments for the 2 patients were performed in a deployed military treatment facility...
June 1, 2017: Medical Acupuncture
https://www.readbyqxmd.com/read/28710443/defying-dissolution-discovery-of-deep-sea-scleractinian-coral-reefs-in-the-north-pacific
#5
Amy R Baco, Nicole Morgan, E Brendan Roark, Mauricio Silva, Kathryn E F Shamberger, Kelci Miller
Deep-sea scleractinian coral reefs are protected ecologically and biologically significant areas that support global fisheries. The absence of observations of deep-sea scleractinian reefs in the Central and Northeast Pacific, combined with the shallow aragonite saturation horizon (ASH) and high carbonate dissolution rates there, fueled the hypothesis that reef formation in the North Pacific was improbable. Despite this, we report the discovery of live scleractinian reefs on six seamounts of the Northwestern Hawaiian Islands and Emperor Seamount Chain at depths of 535-732 m and aragonite saturation state (Ωarag) values of 0...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28687437/brain-projective-reality-novel-clothes-for-the-emperor-reply-to-comments-on-topodynamics-of-metastable-brains-by-arturo-tozzi-et-al
#6
Arturo Tozzi, James F Peters, Andrew A Fingelkurts, Alexander A Fingelkurts, Pedro C Marijuán
No abstract text is available yet for this article.
June 28, 2017: Physics of Life Reviews
https://www.readbyqxmd.com/read/28648981/leptin-s-physiologic-role-does-the-emperor-of-energy-balance-have-no-clothes
#7
REVIEW
Jeffrey S Flier, Eleftheria Maratos-Flier
The discovery of the obese gene and the demonstration that its encoded protein leptin can reverse obesity due to genetic deficiency of the hormone were landmark discoveries in endocrinology and metabolism. Regarding leptin's role in physiology, it is now established that falling leptin levels are a key signal of the starved state in mice and humans. Repleting leptin reverses the starvation signal both in physiologic starvation and in obesity resulting from genetic leptin deficiency. Since its discovery, it has also been hypothesized that rising leptin levels caused by overfeeding provide a physiologic signal that orchestrates resistance to obesity...
July 5, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28648776/the-emperor-has-no-clothes-recognizing-the-limits-of-current-echocardiographic-technology-in-perioperative-quantification-of-mitral-regurgitation
#8
EDITORIAL
Frederick C Cobey, Visal Patel, Andre Gosling, Eric Ursprung
No abstract text is available yet for this article.
March 9, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28645828/cardiac-surgery-training-in-the-present-era-does-the-emperor-have-new-clothes
#9
EDITORIAL
Giuseppe D'Ancona, Hüseyin Ince
No abstract text is available yet for this article.
May 18, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28627996/metastasectomy-for-colorectal-cancer-are-there-clothes-on-the-emperor
#10
Tom Treasure
No abstract text is available yet for this article.
June 2017: Journal of the Royal Society of Medicine
https://www.readbyqxmd.com/read/28609969/an-updated-concept-and-revised-composition-for-i-hamacreadium-i-linton-1910-opecoelidae-plagioporinae-clarifies-a-previously-obscured-pattern-of-host-specificity-among-species
#11
Storm B Martin, Scott C Cutmore, Selina Ward, Thomas H Cribb
The present concept of the trematode genus Hamacreadium Linton, 1910 encompasses considerable morphological variability and includes species reported from a broad range of fishes. These include herbivores and planktivores, despite the life-cycle of the type-species, Hamacreadium mutabile Linton, 1910, being known to use fishes as intermediate hosts. Reports of H. mutabile are numerous, spanning the west Atlantic, east Pacific and Indo-west Pacific, whereas other nominal species are infrequently reported and several inadequately described...
April 12, 2017: Zootaxa
https://www.readbyqxmd.com/read/28580950/pacific-plate-motion-change-caused-the-hawaiian-emperor-bend
#12
Trond H Torsvik, Pavel V Doubrovine, Bernhard Steinberger, Carmen Gaina, Wim Spakman, Mathew Domeier
A conspicuous 60° bend of the Hawaiian-Emperor Chain in the north-western Pacific Ocean has variously been interpreted as the result of an abrupt Pacific plate motion change in the Eocene (∼47 Ma), a rapid southward drift of the Hawaiian hotspot before the formation of the bend, or a combination of these two causes. Palaeomagnetic data from the Emperor Seamounts prove ambiguous for constraining the Hawaiian hotspot drift, but mantle flow modelling suggests that the hotspot drifted 4-9° south between 80 and 47 Ma...
June 5, 2017: Nature Communications
https://www.readbyqxmd.com/read/28558939/the-humboldt-penguin-spheniscus-humboldti-rete-tibiotarsale-a-supreme-biological-heat-exchanger
#13
Shaked Kazas, Moran Benelly, Saar Golan
Humans are unable to survive low temperature environments without custom designed clothing and support systems. In contrast, certain penguin species inhabit extremely cold climates without losing substantial energy to self-heating (emperor penguins ambient temperature plummets to as low as -45°C). Penguins accomplish this task by relying on distinct anatomical, physiological and behavioral adaptations. One such adaptation is a blood vessel heat exchanger called the 'Rete Tibiotarsale' - an intermingled network of arteries and veins found in penguins' legs...
July 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/28545618/nosology-of-noncompaction-cardiomyopathy-the-emperor-still-wears-clothes
#14
EDITORIAL
Erwin Oechslin, Rolf Jenni
No abstract text is available yet for this article.
June 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28529298/an-aspect-of-the-history-of-medicine-in-ancient-korea-as-examined-through-silla-buddhist-monks-annotations-on-the-chapter-on-eliminating-disease-in-the-sutra-of-golden-light-suvarnabh%C3%A4-sa-s%C3%A5-tra
#15
Chaekun Oh, Jongwook Jeon, Dongwon Shin
Nearly nothing is known of medicine in ancient Korea due to insufficient materials. With several extant prescriptions and esoteric methods of treating diseases alone, it is impossible to gauge in depth the management of medicine during this period. If one exception were to be cited, that would be the fact that the annotations for understanding the contents on Indian medicine in the "Chapter on Eliminating Disease" in the Sutra of Golden Light, a Buddhist sutra originating from India, reflected the medical knowledge of Buddhist monks from Silla (57 BC-935 AD) who were active immediately after the nation's unification of the two other kingdoms on the Korean Peninsula (668 AD) such as Wonhyo (617-686 AD), Gyeongheung (620?-700? AD), and Seungjang (684-? AD)...
December 2016: Ŭi Sahak
https://www.readbyqxmd.com/read/28506713/the-emperor-s-new-topology-comment-on-topodynamics-of-metastable-brains-by-arturo-tozzi-et-al
#16
Karl Friston
No abstract text is available yet for this article.
May 11, 2017: Physics of Life Reviews
https://www.readbyqxmd.com/read/28498882/mutational-signatures-and-mutable-motifs-in-cancer-genomes
#17
Igor B Rogozin, Youri I Pavlov, Alexander Goncearenco, Subhajyoti De, Artem G Lada, Eugenia Poliakov, Anna R Panchenko, David N Cooper
Cancer is a genetic disorder, meaning that a plethora of different mutations, whether somatic or germ line, underlie the etiology of the 'Emperor of Maladies'. Point mutations, chromosomal rearrangements and copy number changes, whether they have occurred spontaneously in predisposed individuals or have been induced by intrinsic or extrinsic (environmental) mutagens, lead to the activation of oncogenes and inactivation of tumor suppressor genes, thereby promoting malignancy. This scenario has now been recognized and experimentally confirmed in a wide range of different contexts...
May 11, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/28488293/the-challenges-of-detecting-subtle-population-structure-and-its-importance-for-the-conservation-of-emperor-penguins
#18
Jane L Younger, Gemma V Clucas, Damian Kao, Alex D Rogers, Karim Gharbi, Tom Hart, Karen J Miller
Understanding the boundaries of breeding populations is of great importance for conservation efforts and estimates of extinction risk for threatened species. However, determining these boundaries can be difficult when population structure is subtle. Emperor penguins are highly reliant on sea ice, and some populations may be in jeopardy as climate change alters sea-ice extent and quality. An understanding of emperor penguin population structure is therefore urgently needed. Two previous studies have differed in their conclusions, particularly whether the Ross Sea, a major stronghold for the species, is isolated or not...
August 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28467819/the-concurrent-emergence-and-causes-of-double-volcanic-hotspot-tracks-on-the-pacific-plate
#19
T D Jones, D R Davies, I H Campbell, G Iaffaldano, G Yaxley, S C Kramer, C R Wilson
Mantle plumes are buoyant upwellings of hot rock that transport heat from Earth's core to its surface, generating anomalous regions of volcanism that are not directly associated with plate tectonic processes. The best-studied example is the Hawaiian-Emperor chain, but the emergence of two sub-parallel volcanic tracks along this chain, Loa and Kea, and the systematic geochemical differences between them have remained unexplained. Here we argue that the emergence of these tracks coincides with the appearance of other double volcanic tracks on the Pacific plate and a recent azimuthal change in the motion of the plate...
May 25, 2017: Nature
https://www.readbyqxmd.com/read/28411821/electrochemical-discrimination-of-mints-the-last-chinese-emperors-kuang-hs%C3%A3-and-hs%C3%A3-an-t-ung-monetary-unification
#20
Antonio Doménech-Carbó, María Teresa Doménech-Carbó, Elena Montagna, Carla Álvarez-Romero, Yu Lee
An electrochemical methodology for discriminating monetary emissions, a recurrent problem in much archaeological studies, is introduced. The method is based on the record of voltammetric signatures of cuprite and tenorite corrosion products in the patina using a minimally invasive nanosampling following the voltammetry of immobilized particles methodology. A model for the depth variation of voltammetric electrochemical parameters characterizing the composition of the corrosion patinas is presented. This model permits to rationalize electrochemical data and discriminate different monetary emissions...
July 1, 2017: Talanta
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