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Ngoc P Ly, Augusto Litonjua, Diane R Gold, Juan C Celedón
Current evidence supports a role for gut colonization in promoting and maintaining a balanced immune response in early life. An altered or less diverse gut microbiota composition has been associated with atopic diseases, obesity, or both. Moreover, certain gut microbial strains have been shown to inhibit or attenuate immune responses associated with chronic inflammation in experimental models. However, there has been no fully adequate longitudinal study of the relation between the neonatal gut microbiota and the development of allergic diseases (eg, atopic asthma) and obesity...
May 2011: Journal of Allergy and Clinical Immunology
Ryo Inoue, Takamitsu Tsukahara, Kozo Ueno, Taeru Kitabayashi, Kazunari Ushida
Food allergy was induced in two groups of NC/jic mice. Mice fed frucuto-oligosaccharides showed fewer allergic symptoms than control diet-fed mice. The cecal microbiota compositions were clearly different between the two groups, and the difference was partly attributable to Clostridia possession. A possible link of the compositional change in intestinal micriobiota with the anti-allergic effect of fructo-oligosaccharides is suggested.
2010: Bioscience, Biotechnology, and Biochemistry
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