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Octogenarians

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https://www.readbyqxmd.com/read/29139189/clostridium-difficile-infection-in-hospitalized-octogenarian-patients
#1
Anca Trifan, Irina Girleanu, Carol Stanciu, Egidia Miftode, Camelia Cojocariu, Ana-Maria Singeap, Catalin Sfarti, Stefan Chiriac, Tudor Cuciureanu, Oana Stoica
AIM: To evaluate the risk factors and outcome of Clostridium difficile infection in hospitalized octogenarian patients. METHODS: A retrospective analysis of risk factors and outcome of C. difficile infection in hospitalized octogenarians was carried out at two academic centers in Romania from January 2014 to September 2016. Demographic, clinical and laboratory characteristics; antibiotics and proton pump inhibitors use in-hospital and 2 months before admission; comorbidities; length of hospital stay; treatment; and outcome were carefully collected from the patients' medical charts and compared with those from octogenarians hospitalized during the same period...
November 15, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29138974/medical-complications-and-mortality-in-octogenarians-undergoing-elective-spinal-fusion-surgeries
#2
Sharad Rajpal, E Lee Nelson, Alan T Villavicencio, Jayratna Telang, Roshan Kantha, Kara Beasley, Sigita Burneikiene
BACKGROUND: The consequences of suffering postoperative complications in elderly undergoing spinal surgeries may be different compared to younger patients. The primary objective of this study was to identify the types and frequency of medical complications and mortality rates in patients 80 years of age or older undergoing elective spinal fusion surgeries for degenerative spinal disease. METHODS: A prospective observational study with a retrospective chart review was performed, which included all consecutive patients ≥80 years old undergoing elective spinal fusion surgeries from May 2012 to August 2015...
November 14, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29136258/ultra-short-versus-conventional-uncemented-stems-for-hip-replacement-in-octogenarians
#3
Young-Hoo Kim, Jang-Won Park, Jun-Shik Kim
The aim of this study was to determine how an ultra-short anatomic uncemented stem vs a diaphyseal filling five-eighths porous coated uncemented femoral stem (conventional stem) affects the survival of primary total hip arthroplasties in octogenarians. The current study consisted of 52 patients (55 hips) in the ultra-short stem group (mean age, 85.5±5.3 years) and 61 patients (72 hips) in the diaphyseal (conventional) stem group (mean age, 84.1±4.8 years). The predominant diagnosis was osteoarthritis, followed by osteonecrosis of the femoral head, in both groups...
November 11, 2017: Orthopedics
https://www.readbyqxmd.com/read/29133315/testosterone-in-advance-age-a-new-zealand-longitudinal-cohort-study-life-and-living-in-advanced-age-te-pu%C3%A4-waitanga-o-ng%C3%A4-tapuwae-kia-ora-tonu
#4
Martin J Connolly, Ngaire Kerse, Tim Wilkinson, Oliver Menzies, Anna Rolleston, Yih Harng Chong, Joanna B Broad, Simon A Moyes, Santosh Jatrana, Ruth Teh
OBJECTIVES: Serum testosterone (T) levels in men decline with age. Low T levels are associated with sarcopenia and frailty in men aged >80 years. T levels have not previously been directly associated with disability in older men. We explored associations between T levels, frailty and disability in a cohort of octogenarian men. SETTING: Data from all men from Life and Living in Advanced Age Cohort Study in New Zealand, a longitudinal cohort study in community-dwelling older adults...
November 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/29132701/postoperative-outcome-after-pulmonary-surgery-for-non-small-cell-lung-cancer-in-elderly-patients
#5
Deniece D E M A Detillon, Eelco J Veen
BACKGROUND: Lung cancer is the main cause of cancer-related death in the Netherlands. Surgery offers the best potential cure, but lower rates of surgery are recorded for octogenarians because of concerns regarding morbidity and mortality. METHODS: We analyzed the Dutch Lung Surgery Audit database to determine the postoperative outcome of lung cancer resections for patients aged 60 years or more between January 2013 and December 2014. Three groups were compared: patients aged 80 years or more, patients aged 70 to 79 years, and patients aged 60 to 69 years...
November 10, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29123416/frequency-and-clinical-relevance-of-egfr-mutations-and-eml4-alk-translocations-in-octogenarians-with-non-small-cell-lung-cancer
#6
Amanda Tufman, Kathrin Kahnert, Thomas Duell, Diego Kauffmann-Guerrero, Katrin Milger, Christian Schneider, Julia Stump, Zulfiya Syunyaeva, Rudolf Maria Huber, Simone Reu
Background: Tyrosine kinase inhibitors (TKIs) have improved response rates in some patients with non-small cell lung cancer (NSCLC), and testing for EGFR mutation and ALK translocation is recommended for all patients with advanced lung adenocarcinoma. The frequency of driver mutations in elderly and very elderly patients has not been described. Patients and methods: We reviewed EGFR and ALK in patients over the age of 70 years diagnosed and treated at our center in 2015 (subgroups: 70-74, 75-79 and >80 years)...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29113899/neurosurgery-in-octogenarians-a-prospective-study-on-perioperative-morbidity-mortality-and-complications-in-elderly-patients
#7
Nicolai Maldaner, Johannes Sarnthein, Oliver Bozinov, Luca Regli, Marian Christoph Neidert
OBJECTIVE: The aging population in industrialized countries shifts the age limit for neurosurgical interventions towards increasingly older patients. This study investigates whether octogenarians (≥80 years) stand out in outcome and incidence of perioperative complications. METHODS: Consecutive patients ≥80 years operated between January 2013 to August 2016 were compared against a control group of patients aged 55 - 75 years matched by indication for surgery...
November 4, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29107492/is-rapid-recovery-hip-and-knee-replacements-possible-and-safe-in-the-octogenarian-patient
#8
Paul K Edwards, James R Kee, Simon C Mears, C Lowry Barnes
BACKGROUND: Rapid recovery programs are now aimed to reduce costs of hip and knee arthroplasties by discharging patients directly home, shortening hospital length of stay (LOS), and reducing readmission rates. Although patients aged 80 years and older are included in the Medicare bundle, little work has been performed to determine if older patients can safely participate in rapid recovery programs. METHODS: We retrospectively reviewed 2482 patients undergoing primary and revision total hip and knee arthroplasties (THA and TKA) who all participated in a multifaceted rapid recovery program...
October 6, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29106492/centenarians-differ-in-their-comorbidity-trends-during-the-6-years-before-death-compared-to-individuals-who-died-in-their-80s-or-90s
#9
Paul Gellert, Petra von Berenberg, Monika Oedekoven, Maria Klemt, Christine Zwillich, Stefan Hörter, Adelheid Kuhlmey, Dagmar Dräger
Background: While compression of morbidity has now been studied in multiple cohorts, we hypothesize that centenarians might also have fewer chronic conditions as well. We assume that individuals who die as centenarians have less comorbidities and have a less steep rise of the number of comorbidities over the final years before death compared to those who died as nonagenarians (90-99 years) or octogenarians (80-89 years of age). Methods: This German cohort study used health insurance data...
June 29, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29105781/prediction-of-mortality-and-morbidity-in-head-and-neck-cancer-patients-80-years-of-age-and-older-undergoing-surgery
#10
Heidi E L'Esperance, Dorina Kallogjeri, Shahnawaz Yousaf, Jay F Piccirillo, Jason T Rich
OBJECTIVES: To determine postoperative complications and mortality rates in octogenarian and older head and neck cancer patients undergoing ablative surgical resections and to identify factors associated with postoperative morbidity and mortality. METHODS: Retrospective cohort study investigating risk factors for 30-day serious complication risk and 90-day mortality risk for patients aged 80 years and older who underwent ablative head and neck oncologic surgical procedures at an academic tertiary care center between 2005 and 2015...
November 6, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29102185/relationship-between-lifespan-indicators-and-elemental-background-values-a-case-study-in-guangdong-province-china
#11
Haixia Pu, Kunli Luo, Shixi Zhang, Yajun Du, Chao Zhao
There was a significant difference in the distribution of centenarians at county-level in Guangdong Province, China. To carry out an integrated analysis on elemental background values and their relation to lifespan level, samples of environmental media such as drinking water, staple rice and soil were collected in ten counties (non-longevity and longevity areas) in Guangdong Province. Meanwhile, lifespan indicators were calculated based on census data in 2010: the percentage of population aged 80 to 90years (octogenarian index, 80-90%, OI%), the percentage of population aged 90 to 100years (longevity index, 90-100%, LI%), centenarians per one hundred thousand inhabitants (CH)...
October 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29096969/octogenarian-patients-with-chronic-obstructive-pulmonary-disease-characteristics-and-usefulness-of-prognostic-indexes
#12
Rafael Golpe, María Suárez-Valor, Alejandro Veres-Racamonde, Esteban Cano-Jiménez, Irene Martín-Robles, Pilar Sanjuán-López, Luis Pérez-de-Llano
BACKGROUND AND OBJECTIVE: Most studies on chronic obstructive pulmonary disease (COPD) exclude octogenarian patients. Therefore, the disease is not well characterized in this age group. The objective of this study is to analyze the clinical characteristics of octogenarian patients with COPD and the usefulness of the prognostic indexes used most frequently in this age group. PATIENTS AND METHOD: Retrospective study of consecutive patients seen at a clinic between 2009 and 2017...
October 30, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/29096604/predicting-operative-mortality-in-octogenarians-for-isolated-coronary-artery-bypass-grafting-surgery-a-retrospective-study
#13
Jessica G Y Luc, Michelle M Graham, Colleen M Norris, Sadek Al Shouli, Yugmel S Nijjar, Steven R Meyer
BACKGROUND: Available cardiac surgery risk scores have not been validated in octogenarians. Our objective was to compare the predictive ability of the Society of Thoracic Surgeons (STS) score, EuroSCORE I, and EuroSCORE II in elderly patients undergoing isolated coronary artery bypass grafting surgery (CABG). METHODS: All patients who underwent isolated CABG (2002 - 2008) were identified from the Alberta Provincial Project for Outcomes Assessment in Coronary Heart Disease (APPROACH) registry...
November 2, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29094297/prognostic-accuracy-of-myocardial-perfusion-imaging-in-octogenarians
#14
Francesco Nudi, Giuseppe Biondi-Zoccai, Orazio Schillaci, Natale di Belardino, Francesco Versaci, Alessandro Nudi, Annamaria Pinto, Giandomenico Neri, Enrica Procaccini, Giacomo Frati, Ami E Iskandrian
BACKGROUND: Myocardial perfusion imaging (MPI) has an established role in the work-up of coronary artery disease (CAD), but its comparative accuracy is debated in elderly patients. We examined a large administrative database to appraise the performance of MPI in octogenarians. METHODS: Our institutional database was queried for patients undergoing MPI without recent coronary revascularization or myocardial infarction (MI). We compared baseline, procedural, diagnostic, and prognostic features in patients aged < 80 vs ≥ 80 years with bivariate and propensity-adjusted analyses...
November 1, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29062740/outcomes-of-surgical-and-transcatheter-aortic-valve-replacement-in-the-octogenarians-surgery-still-the-gold-standard
#15
Sameer A Hirji, Fernando Ramirez-Del Val, Ahmed A Kolkailah, Julius I Ejiofor, Siobhan McGurk, Ritam Chowdhury, Jiyae Lee, Pinak B Shah, Piotr S Sobieszczyk, Sary F Aranki, Marc P Pelletier, Prem S Shekar, Tsuyoshi Kaneko
BACKGROUND: Contemporary options for aortic valve replacement (AVR) include transcatheter and surgical approaches (TAVR and SAVR). As evidence accrues for TAVR in high and intermediate risk patients, some clinicians advocate that all patients aged over 80 years should only receive TAVR. Our aim was to investigate the utility of SAVR and minimally invasive AVR (mAVR) among octogenarians in the current era of TAVR. METHODS: From 2002 to 2015, 1,028 octogenarians underwent isolated AVR; 306 TAVR and 722 SAVR, of which 378 patients underwent mAVR...
September 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29056956/clinical-outcomes-of-radiofrequency-catheter-ablation-of-atrial-fibrillation-in-octogenarians-10-year-experience-of-a-one-high-volume-center
#16
Alan Bulava, Jiri Hanis, Ladislav Dusek
BACKGROUND: Prevalence of atrial fibrillation (AF) increases with age. Radiofrequency catheter ablation (RFCA) is an established treatment option superior to antiarrhythmics (AAs). In this study, we investigated safety and efficacy of RFCA of AF in octogenarians. METHODS: From our database, we extracted procedural and follow-up data for patients ≥ 80 years with symptomatic AF undergoing RFCA and compared this population to RFCA patients ≤ 50 years. All patients underwent pulmonary vein isolation (PVI) supplemented by linear lesions in PVI-nonresponders...
September 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29054307/early-and-late-surgical-outcomes-of-acute-type-a-aortic-dissection-in-octogenarians
#17
Koji Kawahito, Naoyuki Kimura, Atsushi Yamaguchi, Kei Aizawa, Yoshio Misawa, Hideo Adachi
BACKGROUND: Although surgical outcomes of acute type A aortic dissection (ATAAD) have improved, it is still a high-risk procedure for octogenarians. This study analyzed early and late outcomes of surgical repair of ATAAD among octogenarians. METHODS: From 1990 through 2016, 1,260 consecutive patients with ATAAD were emergently admitted to Jichi Medical University Hospitals. Of them, 1,026 patients who underwent emergency surgery for ATAAD within 48 hours of symptom onset were included in this retrospective study...
October 17, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29040301/surveying-predictors-of-late-life-longitudinal-change-in-daily-activity-energy-expenditure
#18
Vincenzo Valiani, Sandrine Sourdet, Dale A Schoeller, Dawn C Mackey, Douglas C Bauer, Nancy W Glynn, Yosuke Yamada, Tamara B Harris, Todd M Manini
BACKGROUND: Total daily energy expenditure (TEE) is composed of resting metabolic rate (RMR), post-prandial thermogenesis and activity energy expenditure (AEE). Higher AEE is strongly associated with lower mortality and physical limitations among older adults, but factors that predict changes in AEE in septu and octogenarians are not clearly understood. OBJECTIVE: To identify factors associated with late-life longitudinal change in AEE. DESIGN: Energy expenditure was re-assessed in 83 participants (average age at baseline, 74...
2017: PloS One
https://www.readbyqxmd.com/read/29027735/temporal-trends-in-percutaneous-coronary-interventions-thru-the-drug-eluting-stent-era-insights-from-18-641-procedures-performed-over-12-year-period
#19
Uri Landes, Tamir Bental, Amos Levi, Abid Assali, Hana Vaknin-Assa, Eli I Lev, Eldad Rechavia, Gabriel Greenberg, Katia Orvin, Ran Kornowski
BACKGROUND: The last decade, regarded as the DES era in PCI, has witnessed significant advances in the management of coronary disease. We aimed to assess temporal trends in the practice and outcome of percutaneous coronary intervention (PCI) during the drug eluting stent (DES) era. METHODS: We analyzed 18,641 consecutive PCI's performed between January 2004 and December 2016, distinguished by procedural date (Q1 : 2004-2006, n = 4,865; Q2 : 2007-2009, n = 4,977; Q3 : 2010-2012, n = 4,230; Q4 : 2013-2016, n = 4,569)...
October 13, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29027267/percutaneous-repair-of-severe-mitral-valve-regurgitation-secondary-to-chordae-rupture-in-octogenarians-using-mitraclip
#20
Nicolas Geis, Philip Raake, Derliz Mereles, Emmanuel Chorianopoulos, Gabor Szabo, Hugo A Katus, Raffi Bekeredjian, Sven T Pleger
OBJECTIVES: The aim of this study was to assess feasibility and clinical effectiveness of the MitraClip device in octogenarians suffering from severe mitral valve regurgitation due to chordae rupture. BACKGROUND: The MitraClip procedure is a suitable technique in high-risk surgical patients to achieve safe and effective percutaneous repair of mitral valve regurgitation. Octogenarians show cumulative risk and social aspects hindering mitral valve surgery. No data exists regarding the use of the MitraClip device in high-risk octogenarians suffering from mitral valve chordae rupture...
October 12, 2017: Journal of Interventional Cardiology
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