Fahad Shuja, Christian Shults, Michael Duggan, Malek Tabbara, Muhammad U Butt, Thomas H Fischer, Martin A Schreiber, Brandon Tieu, John B Holcomb, Jill L Sondeen, Marc Demoya, George C Velmahos, Hasan B Alam
BACKGROUND: Trauma-induced coagulopathy is associated with an extremely high mortality. We have recently shown that survival can be improved by correction of coagulopathy through early, aggressive infusion of Fresh Frozen Plasma (FFP). However, FFP is a perishable product, and its use is impractical in challenging environments such as a battlefield. Development of shelf-stable, easy to use, low volume, lyophilized, Freeze-Dried Plasma (FDP) can overcome the logistical limitations. We hereby report the development and testing of such a product...
November 2008: Journal of Trauma