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Adenoid cystic carcinoma

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https://www.readbyqxmd.com/read/28426972/unlocking-the-chromatin-of-adenoid-cystic-carcinomas-using-hdac-inhibitors-sensitize-cancer-stem-cells-to-cisplatin-and-induces-tumor-senescence
#1
Luciana O Almeida, Douglas M Guimarães, Manoela D Martins, Marco A T Martins, Kristy A Warner, Jacques E Nör, Rogerio M Castilho, Cristiane H Squarize
No abstract text is available yet for this article.
April 8, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28424937/model-to-predict-cause-specific-mortality-in-patients-with-head-and-neck-adenoid-cystic-carcinoma-a-competing-risk-analysis
#2
Weidong Shen, Naoko Sakamoto, Limin Yang
PURPOSE: The main objective of this study was to evaluate the cumulative incidence of cause-specific death and other causes of death for patients with head and neck adenoid cystic carcinoma (ACC). The secondary aim was to model the probability of cause-specific death and build a competing risk nomogram to predict cause-specific mortality for this disease. METHODS: Data were extracted from the US National Cancer Institute's Surveillance Epidemiology, and End Results (SEER)-18 dataset...
April 19, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28415633/a-phase-2-study-of-vorinostat-in-locally-advanced-recurrent-or-metastatic-adenoid-cystic-carcinoma
#3
Priscila H Goncalves, Lance K Heilbrun, Michael T Barrett, Shivaani Kummar, Aaron R Hansen, Lillian L Siu, Richard L Piekarz, Ammar W Sukari, Joseph Chao, Mary Jo Pilat, Daryn W Smith, Lindsay Casetta, Scott A Boerner, Alice Chen, Elizabeth Lenkiewicz, Smriti Malasi, Patricia M LoRusso
PURPOSE: Vorinostat is a histone deacetylase inhibitor (HDACi). Based on a confirmed partial response (PR) in an adenoid cystic carcinoma (ACC) patient treated with vorinostat in a prior phase 1 trial, we initiated this phase 2 trial. METHODS: Vorinostat was administered orally 400 mg daily, 28 day cycles. The primary objective was to evaluate response rate (RR). Exploratory studies included whole exome sequencing (WES) of selected patients. RESULTS: Thirty patients were enrolled...
March 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28399336/an-update-on-tumors-of-the-lacrimal-gland
#4
Simon Andreasen, Bita Esmaeli, Sarah Linéa von Holstein, Lauge Hjorth Mikkelsen, Peter Kristian Rasmussen, Steffen Heegaard
Lacrimal gland tumors are rare and constitute a wide spectrum of different entities ranging from benign epithelial and lymphoid lesions to high-grade carcinomas, lymphomas, and sarcomas with large differences in prognosis and clinical management. The symptoms and findings of a lacrimal gland lesion are a growing mass at the site of the lacrimal gland, including displacement of the eyeball, decreased motility, diplopia, and ptosis. Pain is the cardinal symptom of an adenoid cystic carcinoma. Radiological findings characteristically include an oval, well-demarcated mass for benign lesions whereas malignant lesions typically display calcifications, destruction of bone, and invasion of adjacent structures...
March 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28389810/perineural-spread-susceptible-structures-a-non-pathological-evaluation-of-the-skull-base
#5
Francisco J Barrera-Flores, Natalia Villarreal-Del Bosque, Alejandro Díaz González-Colmenero, Carolina Garza-González, Rodolfo Morales-Ávalos, Ricardo Pinales-Razo, Guillermo Elizondo-Riojas, Santos Guzmán-López, Rodrigo E Elizondo-Omaña
Perineural spread adenoid cystic carcinoma can alter the dimension of foramina and canals of the skull base. The objective of this study was to determine the range of normal variation of the foramina and canals of both hemicranium. We analyzed 200 individuals with no alterations of the skull base in a retrospective manner using high-resolution computed tomography. We measured the short and long axis diameters of the foramen rotundum (FR), foramen ovale (FO), stylomastoid foramen (SMF), pterygoid canal (PTC), internal auditory canal (IAC), and the facial nerve canal in its labyrinthine portion (LPFC) to calculate the area in each hemicranium, compare them and obtain the normal range of asymmetry...
April 7, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28386362/b7-h3-regulates-migration-and-invasion-in-salivary-gland-adenoid-cystic-carcinoma-via-the-jak2-stat3-signaling-pathway
#6
Teng-Fei Fan, Wei-Wei Deng, Lin-Lin Bu, Tian-Fu Wu, Wen-Feng Zhang, Zhi-Jun Sun
B7 Homolog 3 (B7-H3), a newly identified member of the B7 family, is over-expressed in various human cancers and plays a vital role in tumor progression. To identify the expression pattern of B7-H3 in human salivary adenoid cystic carcinoma (AdCC) and its underlying mechanisms, we characterized B7-H3 expression in AdCC tissue microarrays using immunohistochemical staining, and analyzed potentially associated molecules. The results showed that B7-H3 was highly expressed in salivary AdCC, compared with normal salivary glands...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28386337/down-regulation-of-mir-125a-5p-is-associated-with-salivary-adenoid-cystic-carcinoma-progression-via-targeting-p38-jnk-erk-signal-pathway
#7
Yancan Liang, Jiantao Ye, Jiuyang Jiao, Jin Zhang, Yingjuan Lu, Li Zhang, Di Wan, Liming Duan, You Wu, Bin Zhang
Salivary adenoid cystic carcinoma (SACC) is a relatively uncommon epithelial-like malignancy that can occur in the head and neck region. Despite its slow growth, this aggressive salivary gland tumor frequently recurs and metastasizes to distant organs since lacking effective chemotherapy treatment. MicroRNAs are key regulators in tumor metastasis and progression, but their roles during SACC progression have not been illustrated. In current study, we demonstrate that miR-125a-5p is down-regulated in SACC and closely related to the metastasis and progression in human SACC specimens...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28382475/breast-adenoid-cystic-carcinoma-report-of-a-case-with-emphasis-on-routine-sonographic-findings-and-shear-wave-elastography
#8
Min Huang, Tian'an Jiang, Qiyu Zhao, Qihan You, Guo Tian, Baohua Wang
Adenoid cystic carcinoma (ACC) of the breast is a rare malignant tumor. Its sonographic characteristics have been described in some reports, but there are few such reports available that describe the sonoelastographic findings of this tumor and provide additional information about the nature of the lesion. In this case report, we describe the routine sonographic findings and shear wave elastography findings of a breast adenoid cystic carcinoma in a 53-year-old woman.
April 5, 2017: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/28377480/a-phase-ii-study-of-dovitinib-in-patients-with-recurrent-or-metastatic-adenoid-cystic-carcinoma
#9
Patrick M Dillon, Gina R Petroni, Bethany J Horton, Christopher A Moskaluk, Paula M Fracasso, Michael G Douvas, Nikole Varhegyi, Snjezana Zaja-Milatovic, Christopher Y Thomas
Purpose: Genetic and preclinical studies have implicated fibroblast growth factor receptor (FGFR) signaling in the pathogenesis of adenoid cystic carcinoma (ACC). Dovitinib, a suppressor FGFR activity, may be active in ACC. <p>Methods: In a two-stage phase II study, 35 patients with progressive ACC were treated with dovitinib 500mg orally for 5 of 7 days continuously.  The primary endpoints were objective response rate (ORR) and change in tumor growth rate (TGR). Progression-free survival (PFS), overall survival (OS), metabolic response, biomarker and QOL were secondary endpoints...
April 4, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28370900/sinonasal-adenoid-cystic-carcinoma-treatment-outcomes-and-association-with-human-papillomavirus
#10
Eric D Miller, Dukagjin M Blakaj, Benjamin J Swanson, Weihong Xiao, Maura L Gillison, Lai Wei, Aashish D Bhatt, Virginia M Diavolitsis, Jessica L Wobb, Stephen Y Kang, Ricardo L Carrau, John C Grecula
BACKGROUND: The purpose of this study was to review long-term outcomes of sinonasal adenoid cystic carcinoma (ACC) and to clarify its association with human papillomavirus (HPV). METHODS: The medical records of 23 patients with sinonasal ACC treated with primary surgical resection between 1998 and 2013 were reviewed. Tissue specimens were available for 17 patients. The p16 testing was performed using immunohistochemistry (IHC), and HPV infection was determined using quantitative polymerase chain reaction (PCR) with primers targeting the E6/E7 region...
April 3, 2017: Head & Neck
https://www.readbyqxmd.com/read/28370175/expression-of-cancer-testis-antigens-in-salivary-gland-carcinomas-with-reference-to-mage-a-and-ny-eso-1-expression-in-adenoid-cystic-carcinoma
#11
Shintaro Beppu, Yohei Ito, Kana Fujii, Kousuke Saida, Hisashi Takino, Ayako Masaki, Takayuki Murase, Kimihide Kusafuka, Yoshiyuki Iida, Tetsuro Onitsuka, Yasushi Yatabe, Nobuhiro Hanai, Yasuhisa Hasegawa, Kei Ijichi, Shingo Murakami, Hiroshi Inagaki
BACKGROUND: Salivary gland carcinomas comprise a group of heterogeneous lesions with complex clinicopathological characteristics and distinct biological behaviors. However, recurrent or metastatic tumors are difficult to treat with currently available therapies. Cancer-testis antigens (CTAs) are detected in cancer cells but not in healthy normal tissues, with the exception of gametogenic tissues. CTAs are highly immunogenic proteins and thus represent ideal targets for cytotoxic T-lymphocyte-mediated specific immune therapy...
March 28, 2017: Histopathology
https://www.readbyqxmd.com/read/28367175/analysis-of-orbital-malignancies-presenting-in-a-tertiary-care-hospital-in-pakistan
#12
Asad Aslam Khan, Suhail Sarwar, Mohammad Ali A Sadiq, Imran Ahmad, Nayab Tariq, Sibghat-Ul-Noor
OBJECTIVE: To determine the frequencies of various orbital malignancies amongst orbital lesions in patients presenting in a tertiary care hospital in Pakistan. METHODS: A retrospective analysis of 666 orbital cases with an established histopathological diagnosis of malignant tumors treated in Mayo Hospital Lahore from 1996 to 2015 (20 years). RESULTS: About 66% of the malignant tumors were primary, 25% secondary, 8% haematopoietic and 1% metastatic...
January 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28348909/adenoid-cystic-carcinoma-of-the-uterine-cervix-a-report-of-2-cases
#13
Meryem Rais, Jinane Kharmoum, Soumaya Ech-Charif, Basma El Khannoussi
Adenoid cystic carcinoma is malignant tumor that exceptionally occurs in the uterine cervix. It is mostly seen in postmenopausal women and has an aggressive clinical course. We report two cases of an adenoid cystic carcinoma associated with a high grade squamous intraepithelial lesion and invasive squamous cell carcinoma of the uterine cervix and discuss briefly its clinical and pathological characteristics.
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28346650/submandibular-salivary-gland-tumors-clinical-course-and-outcome-of-a-20-year-multicenter-study
#14
Aviram Mizrachi, Gideon Bachar, Yaron Unger, Ohad Hilly, Dan M Fliss, Thomas Shpitzer
The purpose of this retrospective chart review study was to review the nature and clinical course of benign and malignant submandibular gland tumors at 2 major university-affiliated tertiary medical centers. All patients who underwent submandibular salivary gland excision between 1990 and 2010 were included. Clinical and disease-related data were collected from the medical charts. One hundred ninety-three patients were identified, of whom 108 (56%) had non-neoplastic disorders (sialolithiasis and sialadenitis)...
March 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28341276/lung-metastasectomy-in-adenoid-cystic-cancer-is-it-worth-it
#15
Lara Girelli, Laura Locati, Carlotta Galeone, Paolo Scanagatta, Leonardo Duranti, Lisa Licitra, Ugo Pastorino
BACKGROUND AND PURPOSE: Adenoid cystic carcinoma (ACC) of salivary glands is characterized by long-term distant metastasis, most commonly in lungs. No agreement has been reached about the role of surgical treatment of pulmonary lesions. We evaluated the long-term results of lung metastasectomy for ACC in order to identify factors that should be taken into account in selecting patients eligible for surgery and treatment planning. PATIENTS AND METHODS: A retrospective study was conducted on 109 patients selected from our institutional experience and from the International Registry of Lung Metastases...
February 2017: Oral Oncology
https://www.readbyqxmd.com/read/28340916/erratum-to-head-and-neck-adenoid-cystic-carcinoma-a-prospective-multicenter-refcor-study-of-95-cases-eur-ann-otorhinolaryngol-head-neck-dis-133-1-2016-13-7
#16
M Meyers, B Granger, P Herman, F Janot, R Garrel, N Fakhry, G Poissonnet, A-C Baglin, M Lefèvre, B Baujat
No abstract text is available yet for this article.
December 2016: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/28340379/knockdown-of-ska1-gene-inhibits-cell-proliferation-and-metastasis-in-human-adenoid-cystic-carcinoma
#17
Li-Juan Zhao, Hong-Li Yang, Ke-Yi Li, Yue-Hua Gao, Kai Dong, Zhong-Hao Liu, Le-Xin Wang, Bin Zhang
The spindle and kinetochore-associated complex subunit 1(SKA1) is a newly discovered gene, which has been associated with mitosis and tumorigenesis. However, its role insalivary adenoid cystic carcinoma (SACC) is still unknown, and the invasive and metastatic mechanism in SACC is still unclear. To explore the molecular mechanism of SKA1 in the process of malignant proliferation and metastasis in adenoid cystic cancer (ACC) cells, we employed lentivirus-mediated short hairpin RNA to knockdown SKA1 in SACC-83 cells...
March 21, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28337279/agr2-promotes-the-proliferation-migration-and-regulates-epithelial-mesenchymal-transition-in-salivary-adenoid-cystic-carcinoma
#18
Si-Rui Ma, Liang Mao, Wei-Wei Deng, Yi-Cun Li, Lin-Lin Bu, Guang-Tao Yu, Wen-Feng Zhang, Zhi-Jun Sun
Salivary adenoid cystic carcinoma (AdCC) is a common head and neck cancer with the propensity for local spread and distant metastasis. In our previous study, elevated expression of Anterior gradient 2 (AGR2) was detected in head and neck squamous cell carcinoma (HNSCC), associated with epithelial-mesenchymal transition (EMT) and cancer stemness. However, to date, the expression and function of AGR2 in AdCC has yet to be elucidated. In the present study, human AdCC tissue microarrays including 18 cases of normal salivary gland (NSG), 12 cases of pleomorphic adenoma (PMA) and 72 cases of AdCC were employed for immunohistochemical staining analysis...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28331738/sentinel-node-biopsy-in-special-histologic-types-of-invasive-breast-cancer
#19
Montserrat Solà, Mireia Recaj, Eva Castellà, Pere Puig, Josep Maria Gubern, Juan Francisco Julian, Manel Fraile
OBJECTIVE: To assess the feasibility of sentinel node biopsy (SNB) in ductal and lobular invasive breast cancer, a group of tumors known as special histologic type (SHT) of breast cancer. MATERIALS AND METHODS: Between January 1997 and July 2008, 2253 patients from 6 affiliated hospitals underwent SNB who had early breast cancer and clinically negative axilla. The patients' data were collected in a multicenter database. For lymphatic mapping, all patients received an intralesional dose of radiocolloid Tc-99m (4mCi in 0...
April 2016: Journal of Breast Health (2013)
https://www.readbyqxmd.com/read/28331271/adenoid-cystic-carcinoma-of-trachea
#20
Ashish Varghese, Swati Suneha, John C Watkinson
Adenoid cystic carcinoma (ACC) is the second most common primary malignant tumor of the trachea, after squamous cell carcinoma. Patients present with upper airway obstructive symptoms and signs including dyspnoea, cough, haemoptysis, and stridor which are often insidious, delaying diagnosis and optimal management. Described here is an unusual case of primary ACC cervical trachea with concomitant micropapillary thyroid carcinoma (microPTC) in a middle-aged lady presenting with cough and breathing difficulty since 3 months...
February 2017: Indian Journal of Surgery
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