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Adenoid cystic carcinoma

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https://www.readbyqxmd.com/read/28935487/clinical-prognostic-factors-of-salivary-adenoid-cystic-carcinoma-a%C3%A2-single-center-analysis-of-61-patients
#1
Robert Cordesmeyer, Henning Schliephake, Philipp Kauffmann, Markus Tröltzsch, Rainer Laskawi, Philipp Ströbel, Felix Bremmer
PURPOSE: Adenoid cystic carcinomas are rare malignant tumors of the salivary glands. They are characterized by a high rate of local recurrence, late distant metastasis and a poor disease-free survival. In this study, we analyzed a series of 61 patients who were all treated at the University of Göttingen over a period of 21.0 years. MATERIALS AND METHODS: In all 61 patients with salivary adenoid cystic carcinoma, clinical data, demographic data, risk factors, tumor location, tumor stage, status of surgical margin, surgical treatment, postoperative radiotherapy and follow-up interval were assessed...
August 10, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28935346/resection-of-the-tracheobronchial-bifurcation-with-complete-preservation-of-lung-parenchyma
#2
Georgios Stamatis, Sylvia Fechner, Miguel Rocha, Gerhard Weinreich
BACKGROUND: The resection of the tracheobronchial bifurcation with complete preservation of lung parenchyma remains a challenge owing to the limited indications for surgery, anesthesiologic management, operative technique, and postoperative course. The aim of this retrospective study was to evaluate factors influencing the perioperative course and long-term survival. METHODS: Between 1989 and 2014, 19 patients underwent a resection of the distal trachea and carina with complete preservation of lung tissue, 16 for malignant tumors (7 adenoid cystic carcinomas, 3 carcinoid tumors, 3 mucoepidermoid tumors, 2 squamous cell carcinomas, and 1 small cell carcinomas), 2 for inflammatory stenosis, and 1 after a complex traumatic rupture...
September 18, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28932028/cytological-spectrum-of-salivary-gland-lesions-and-their-correlation-with-epidemiological-parameters
#3
Vaneet Kaur Sandhu, Upender Sharma, Navtej Singh, Arun Puri
BACKGROUND: The role fine-needle aspiration (FNA) in the diagnosis of salivary gland lesions has evolved over the years. Although clinical and radiological parameters help to narrow the differential diagnosis the tissue diagnosis still remains the gold standard. MATERIALS AND METHODS: This study is from January 2013 to December 2015 in our Department of Pathology where 170 salivary gland lesions were aspirated. The aim of the present study was to analyze adequacy rate in relation to the size of lesion and to evaluate varied cytological spectrum of salivary gland lesions with emphasis on differential diagnosis and to correlate cytological diagnosis with age, gender and anatomical site...
May 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28930925/conical-modification-of-forearm-free-flaps-for-single-stage-reconstruction-after-total-orbital-exenteration
#4
Chad A Purnell, Elbert E Vaca, Marco F Ellis
BACKGROUND: Orbital exenteration is a significant reconstructive challenge for plastic surgeons. Options described for these defects range from healing by secondary intention to free tissue transfer. The authors present our preferred reconstruction of orbital defects with free forearm-based flaps, which provides quality soft tissue and orbital contouring in 1 stage to consistently allow placement of bone-anchored implants for eventual orbital prosthesis. METHODS: This conical shape of the orbit is deconstructed into a "Pac-Man" type shaped flap that leaves adequate depth for a prosthesis...
September 19, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28930752/salivary-gland-neoplasms-does-morphological-diversity-reflect-tumor-heterogeneity
#5
Miguel Rito, Isabel Fonseca
Salivary gland tumor classification encompasses a vast list of benign and malignant neoplasms. Their morphological diversity is recognized not only between different entities but also within individual tumors. Tumor categories as described by the World Health Organization reflect, in part, a true genetic heterogeneity (e.g., translocations involving CRTC1 and CRTC3-MAML2 genes in mucoepidermoid carcinoma and MYB-NFIB fusion in adenoid cystic carcinoma). Carcinoma ex pleomorphic adenoma shows diversity in its histological appearance, but recurrent rearrangements on PLAG1 and HMGA2 are common to its benign precursor...
September 21, 2017: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28914715/diffuse-staining-for-activated-notch1-correlates-with-notch1-mutation-status-and-is-associated-with-worse-outcome-in-adenoid-cystic-carcinoma
#6
Dipti P Sajed, William C Faquin, Chris Carey, Eric A Severson, Amir H Afrogheh, Carl A Johnson, Stephen C Blacklow, Nicole G Chau, Derrick T Lin, Jeffrey F Krane, Vickie Y Jo, Joaquín J Garcia, Lynette M Sholl, Jon C Aster
NOTCH1 is frequently mutated in adenoid cystic carcinoma (ACC). To test the idea that immunohistochemical (IHC) staining can identify ACCs with NOTCH1 mutations, we performed IHC for activated NOTCH1 (NICD1) in 197 cases diagnosed as ACC from 173 patients. NICD1 staining was positive in 194 cases (98%) in 2 major patterns: subset positivity, which correlated with tubular/cribriform histology; and diffuse positivity, which correlated with a solid histology. To determine the relationship between NICD1 staining and NOTCH1 mutational status, targeted exome sequencing data were obtained on 14 diffusely NICD1-positive ACC specimens from 11 patients and 15 subset NICD1-positive ACC specimens from 15 patients...
September 13, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28900283/a-multiplex-preclinical-model-for-adenoid-cystic-carcinoma-of-the-salivary-gland-identifies-regorafenib-as-a-potential-therapeutic-drug
#7
Chen Chen, Sujata Choudhury, Darawalee Wangsa, Chamille J Lescott, Devan J Wilkins, Praathibha Sripadhan, Xuefeng Liu, Danny Wangsa, Thomas Ried, Christopher Moskaluk, Michael J Wick, Eric Glasgow, Richard Schlegel, Seema Agarwal
Adenoid cystic carcinomas (ACC) are rare salivary gland cancers with a high incidence of metastases. In order to study this tumor type, a reliable model system exhibiting the molecular features of this tumor is critical, but none exists, thereby inhibiting in-vitro studies and the analysis of metastatic behavior. To address this deficiency, we have coupled an efficient method to establish tumor cell cultures, conditional reprogramming (CR), with a rapid, reproducible and robust in-vivo zebrafish model. We have established cell cultures from two individual ACC PDX tumors that maintain the characteristic MYB translocation...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28899226/adenoid-cystic-carcinoma-of-the-head-and-neck-a-retrospective-multicenter-study
#8
Shinji Takebayashi, Shogo Shinohara, Hisanobu Tamaki, Ichiro Tateya, Morimasa Kitamura, Masanobu Mizuta, Shinzo Tanaka, Tsuyoshi Kojima, Ryo Asato, Toshiki Maetani, Koji Ushiro, Yoshiharu Kitani, Kazuyuki Ichimaru, Keigo Honda, Koichiro Yamada, Koichi Omori
BACKGROUND: Adenoid cystic carcinoma of the head and neck (ACCHN) is rare and difficult to study effective treatment at one institute. Our aim is to identify prognostic factors for this disease by conducting a multicenter study at 11 institutions in Japan. METHODS: A retrospective multicenter study of ACCHN was performed. One hundred and three patients were identified between 2006 and 2015. The overall survival (OS) rate for all patients was calculated, and OS, locoregional control (LRC) rate, or no distant metastasis (NDM) rate was calculated for patients in that the surgery was performed without distant metastasis (DM)...
September 12, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28894575/genomic-imbalances-and-myb-fusion-in-synchronous-bilateral-adenoid-cystic-carcinoma-and-invasive-lobular-carcinoma-of-the-breast
#9
Anikó Kovács, Fredrik Persson, Marta Persson, Mattias K Andersson, Göran Stenman
The incidence of synchronous bilateral breast carcinomas (BBCs) has increased with a more frequent use of magnetic resonance imaging screening of the contralateral breast in women with newly diagnosed breast cancer. A total of 30% of all BBCs occur synchronously. In the present study, we describe a unique case of synchronous BBC in a 59-year-old previously healthy woman with no known family history of breast or ovarian cancer. At the time of diagnosis the patient had an invasive lobular carcinoma (ILC) in the right breast and an adenoid cystic carcinoma (ACC) in the left breast...
September 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28892250/case-report-of-apatinib-mesylate-treatment-in-rare-advanced-tracheal-adenoid-cystic-carcinoma
#10
Hongmei Wang
A 57-year-old man was admitted to our department 10 years ago, diagnosed with tracheal adenoid cystic carcinoma. After discontinuing chemotherapy and radiotherapy, the disease recurred in December 2016. Apatinib mesylate (500 mg/day) was administered and computed tomography revealed that his symptoms were significantly relieved. Treatment with apatinib mesylate represents a novel method of treatment for tracheal adenoid cystic carcinoma.
September 11, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28889233/adenoid-cystic-carcinoma-of-the-cavernous-sinus-otolaryngological-sequelae-of-therapy-case-report
#11
Edyta Dzięciołowska-Baran, Aleksandra Gawlikowska-Sroka
A 60-year-old woman, otherwise in a good health condition, was first admitted to the hospital with a year-long tingling sensations of the right half of the face, which gradually turned into severe neuralgia corresponding to maxillary (V2) and mandibular (V3) branches of the right trigeminal nerve. MRI scans of the head revealed an unusual hyperplastic or inflammatory changes along the brain base, cavernous sinus extending toward the pterygopalatine fossa, and lateral pterygoid on the right side. Meningioma was suspected and neuralgia was treated conservatively...
September 10, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28879643/adenoid-cystic-carcinoma-of-the-oral-cavity-radiology-pathology-correlation
#12
Imran Uraizee, Nicole A Cipriani, Daniel T Ginat
Adenoid cystic carcinoma in the oral cavity is an uncommon salivary gland malignancy that has a propensity for perineural spread. A high-grade variant is evidenced by an abundance of pleomorphic cells, loss of the classic biphasic epithelial-myoepithelial growth pattern, and comedonecrosis, as well as elevated Ki-67. CT and MRI can both be useful for demonstrating the extent of invasion in oral cavity-associated adenoid cystic carcinoma, which can attain the inferior alveolar nerve for perineural spread by direct invasion through the mandible...
September 6, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28878654/advanced-tracheal-adenoid-cystic-carcinoma-with-thyroid-invasion-mimicking-thyroid-cancer-treated-with-definitive-radiation-case-report-and-review-of-the-literature
#13
Sondos Al Khatib, Wafa Asha, Omar Khzouz, Farid Barakat, Jamal Khader
A 54-year-old female patient, a breast cancer survivor and a case of unresectable adenoid cystic carcinoma of the trachea, with thyroid invasion, presented with suprasternal neck swelling mimicking thyroid primary. A literature search was undertaken to highlight this rare presentation. There have been few reports in the literature describing tracheal adenoid cystic carcinoma involving the thyroid.
May 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28877065/hpv-related-multiphenotypic-sinonasal-carcinoma-an-expanded-series-of-49-cases-of-the-tumor-formerly-known-as-hpv-related-carcinoma-with-adenoid-cystic-carcinoma-like-features
#14
Justin A Bishop, Simon Andreasen, Jen-Fan Hang, Martin J Bullock, Tiffany Y Chen, Alessandro Franchi, Joaquin J Garcia, Douglas R Gnepp, Carmen R Gomez-Fernandez, Stephan Ihrler, Ying-Ju Kuo, James S Lewis, Kelly R Magliocca, Stefan Pambuccian, Ann Sandison, Emmanuelle Uro-Coste, Edward Stelow, Katalin Kiss, William H Westra
Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma (HMSC), originally known as HPV-related carcinoma with adenoid cystic carcinoma-like features, is a peculiar neoplasm that is restricted to the sinonasal tract, exhibits features of both a surface-derived and salivary gland carcinoma (particularly adenoid cystic carcinoma), and is associated with high-risk HPV. Given the limited number of published cases, the full clinicopathologic spectrum of this neoplasm is unclear. Here, we present an updated experience of 49 cases...
September 4, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28868280/optic-disc-pyogenic-granuloma
#15
Eduardo F Marback, Luciano Espinheira Fonseca, Roberto L Marback
AIM: The aim of this paper was to report a rare presentation of adenoid cystic carcinoma. METHOD: This is a case report presenting clinical, radiographic, and histopathologic findings. RESULTS: A 72-year-old female with no reported ocular symptoms was found to have an incidental right orbital mass on imaging. Additional studies revealed multiple liver lesions, which were biopsied and found to be consistent with adenoid cystic carcinoma. She was then referred to the ophthalmology service, where ocular examination demonstrated 2...
July 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28867902/adenoid-cystic-carcinoma-presenting-as-abducens-nerve-palsy-secondary-to-cavernous-sinus-lesion
#16
Christopher Donaldson, Bryden Dawes, Vivek Rathi, Kristian Bulluss
BACKGROUND: We report a 61-year-old who presented with a right-sided abducens nerve palsy secondary to a middle cranial fossa adenoid cystic carcinoma (ACC) extending into the cavernous sinus. PURPOSE: This case represents a unique presentation of intracranial ACC with a large middle cranial fossa mass and only a small extracranial component. METHODS: Review of the literature was undertaken to identify cases of intracranial ACC and their range of presentations...
July 2017: Annals of Neurosciences
https://www.readbyqxmd.com/read/28820917/whole-exome-sequencing-of-lacrimal-gland-adenoid-cystic-carcinoma
#17
David W Sant, Wensi Tao, Matthew G Field, Daniel Pelaez, Ke Jin, Anthony Capobianco, Sander R Dubovy, David T Tse, Gaofeng Wang
Purpose: To identify genomic mutations in lacrimal gland adenoid cystic carcinoma (LGACC) samples from patients. Methods: Genomic DNA was extracted from LGACC specimens. Whole exome sequencing (exome-seq) was conducted to screen for mutations. Capillary sequencing was performed to verify mutations in genes shared by multiple samples. Luciferase assays were used to evaluate functional consequences of NOTCH1 mutations. Results: The mutation profile of LGACC was complicated...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28816699/ceruminous-adenoid-cystic-carcinoma-of-external-auditory-canal
#18
Andrew E Ebelhar, Dava S West, Rony K Aouad
An adenoid cystic carcinoma (AdCC) of the ceruminous glands is very rare; its diagnosis is most often challenging, and simple biopsies may be misleading. Our paper describes a case of a circumferential mass of the left ear canal that was initially reported as a basal cell carcinoma on biopsies in the clinic and on frozen sections intraoperatively. The final pathology was an AdCC of the ceruminous glands of the external auditory canal. Our case reflects the difficulty in the diagnosis of an AdCC of the ceruminous gland and the importance of keeping broad differential diagnoses in mind when counseling patients with masses in the ear canals until final pathology is obtained...
August 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/28807231/bartholin-gland-cancer
#19
REVIEW
Violante Di Donato, Assunta Casorelli, Erlisa Bardhi, Flaminia Vena, Marchetti Claudia, Ludovico Muzii, Pierluigi Benedetti Panici
INTRODUCTION: Bartholin gland carcinoma is an extremely rare condition. Because of its, phase III trials have not been carried out, there exists no unanimous consensus on treatment and guidelines are missing. METHODS: All studies reporting cases of Bartholin cancer were collected and screened for the evaluations. Baseline characteristics of studies were extracted and were queried in a database. RESULTS: A total number of 133 manuscripts collected were available for the review process, representing a total number of 275 reported cases...
September 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28806666/doxorubicin-loaded-environmentally-friendly-carbon-dots-as-a-novel-drug-delivery-system-for-nucleus-targeted-cancer-therapy
#20
Yifang Yuan, Bin Guo, Liying Hao, Na Liu, Yunfeng Lin, Wushuang Guo, Xiaoguang Li, Bin Gu
Chemotherapy is widely applied against various kinds of carcinoma. Generally, chemotherapeutic agents, such as Doxorubicin (DOX), Paclitaxel (PTX), 5-Fluorouracil (5-FU), Methotrexate (MTX), and Vinblastine (VLB) are combined with a view to maximizing their efficacy. Unfortunately, chemotherapeutics are indiscriminate and also kill normal healthy cells, resulting in serious side effects. This non-productive and destructive distribution of chemotherapeutics is regarded as one of the largest problems associated with chemotherapy...
July 10, 2017: Colloids and Surfaces. B, Biointerfaces
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