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https://www.readbyqxmd.com/read/28245357/optimization-and-application-of-direct-infusion-nanoelectrospray-hrms-method-for-large-scale-urinary-metabolic-phenotyping-in-molecular-epidemiology
#1
Elena Chekmeneva, Gonçalo Dos Santos Correia, Queenie Chan, Anisha Wijeyesekera, Adrienne Tin, Jeffery Hunter Young, Paul Elliott, Jeremy K Nicholson, Elaine Holmes
Large-scale metabolic profiling requires the development of novel economical high-throughput analytical methods to facilitate characterization of systemic metabolic variation in population phenotypes. We report a fit-for-purpose direct infusion nanoelectrospray high-resolution mass spectrometry (DI-nESI-HRMS) method with time-of-flight detection for rapid targeted parallel analysis of over 40 urinary metabolites. The newly developed 2 min infusion method requires <10 μL of urine sample and generates high-resolution MS profiles in both positive and negative polarities, enabling further data mining and relative quantification of hundreds of metabolites...
March 14, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28229522/fused-silica-capillaries-with-two-segments-of-different-internal-diameters-and-inner-surface-roughnesses-prepared-by-etching-with-supercritical-water-and-used-for-volume-coupling-electrophoresis
#2
Marie Horká, Pavel Karásek, Michal Roth, Karel Šlais
In the present work, single-piece fused silica capillaries with two different internal diameter segments featuring different inner surface roughness were prepared by new etching technology with supercritical water and used for volume coupling electrophoresis. The concept of separation and on-line pre-concentration of analytes in high conductivity matrix is based on the on-line large-volume sample pre-concentration by the combination of transient isotachophoretic stacking and sweeping of charged proteins in micellar electrokinetic chromatography using non-ionogenic surfactant...
February 22, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28186746/unearthing-a-well-defined-highly-active-bimetallic-w-ti-precatalyst-anchored-on-a-single-silica-surface-for-metathesis-of-propane
#3
Manoja K Samantaray, Santosh Kavitake, Natalia Morlanés, Edy Abou-Hamad, Ali Hamieh, Raju Dey, Jean-Marie Basset
Two compatible organometallic complexes, W(Me)6 (1) and TiNp4 (2), were successively anchored on a highly dehydroxylated single silica support (SiO2-700) to synthesize the well-defined bimetallic precatalyst [(≡Si-O-)W(Me)5(≡Si-O-)Ti(Np)3] (4). Precatalyst 4 was characterized at the molecular level using advanced surface organometallic chemistry (SOMC) characterization techniques. The strong autocorrelation observed between methyl of W and Ti in (1)H-(1)H multiple-quantum NMR spectra demonstrates that W and Ti species are in close proximity to each other...
February 23, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27605381/simultaneous-determination-of-multiple-intracellular-primary-metabolites-by-ultrahigh-performance-liquid-chromatography-coupled-with-a-q-exactive-hf-mass-spectrometer
#4
Nannan Qiu, Di Wu, Xia Cui, Guoliang Li, Sai Fan, Dawei Chen, Yunfeng Zhao, Yongning Wu
In this study, we established an ultrahigh-performance liquid chromatography-Q Exactive HF MS (UHPLC-HF MS) method for the simultaneous determination of 25 targeted metabolites relating to a broad coverage of central metabolic pathways, such as glycolysis pathway, tricarboxylic acid cycle (TCA), serine biosynthesis pathway (SSP), glutaminolysis pathway, and closely related biosynthetic reactions. A Shodex Asahipak NH2P-50 2D column was used to separate the targeted compounds, and Full MS + PRM detection using an electrospray ionization source in negative mode was employed...
October 4, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27505000/an-inverse-method-to-estimate-the-root-water-uptake-source-sink-term-in-soil-water-transport-equation-under-the-effect-of-superabsorbent-polymer
#5
Renkuan Liao, Peiling Yang, Wenyong Wu, Shumei Ren
The widespread use of superabsorbent polymers (SAPs) in arid regions improves the efficiency of local land and water use. However, SAPs' repeated absorption and release of water has periodic and unstable effects on both soil's physical and chemical properties and on the growth of plant roots, which complicates modeling of water movement in SAP-treated soils. In this paper, we proposea model of soil water movement for SAP-treated soils. The residence time of SAP in the soil and the duration of the experiment were considered as the same parameter t...
2016: PloS One
https://www.readbyqxmd.com/read/26783528/tensile-bond-strengths-of-two-adhesives-on-irradiated-and-nonirradiated-human-dentin
#6
Cécile Bernard, Cyril Villat, Hazem Abouelleil, Marie-Paule Gustin, Brigitte Grosgogeat
The aim of this study was to assess the effect of radiotherapy on bond efficiency of two different adhesive systems using tensile bond strength test. Twenty extracted teeth after radiotherapy and twenty nonirradiated extracted teeth were used. The irradiation was applied in vivo to a minimal dose of 50 Gy. The specimens of each group were randomly assigned to two subgroups to test two different adhesive systems. A three-step/etch-and-rinse adhesive system (Optibond FL) and a two-steps/self-etch adhesive system (Optibond XTR) were used...
2015: BioMed Research International
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