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https://www.readbyqxmd.com/read/29350336/brain-over-bladder-a-systematic-review-of-dual-cholinesterase-inhibitor-and-urinary-anticholinergic-use
#1
REVIEW
Laura K Triantafylidis, Jenna S Clemons, Emily P Peron, John Roefaro, Kristin M Zimmerman
BACKGROUND: Case reports have demonstrated that dual use of cholinesterase inhibitors (ChIs) and urinary anticholinergics (UAChs) in older adults may be associated with delusions, aggression, changes in cognition, and anxiety, which typically resolve on drug discontinuation. Despite opposing mechanisms of action, these drugs continue to be co-prescribed. OBJECTIVE: This systematic review evaluates cognitive and functional outcomes of dual use of ChIs and UAChs and describes its prevalence...
January 19, 2018: Drugs & Aging
https://www.readbyqxmd.com/read/29350091/stent-assisted-coiling-of-cerebral-aneurysms-with-the-neuroform-atlas-stent
#2
Ferdi Cay, Ahmet Peker, Anıl Arat
Objectives The Neuroform Atlas stent (AS) is the smallest intracranial stent with an open-cell design. This study reports the first clinical experience with AS. Methods All intracranial aneurysms treated by stent-assisted coiling using a single AS in a single institution were retrospectively evaluated. Patient demographics, aneurysm characteristics, angles between the parent artery and stented branch, technical success, and clinical and angiographic follow-up were analyzed. Results Fifty-five consecutive aneurysms treated with AS-assisted coiling were included...
January 1, 2018: Interventional Neuroradiology
https://www.readbyqxmd.com/read/29349927/treatment-related-toxicities-of-immune-checkpoint-inhibitors-in-advanced-cancers-a-meta-analysis
#3
Johnathan Man, Georgia Ritchie, Matthew Links, Sally Lord, Chee Khoon Lee
BACKGROUND: We performed a meta-analysis to quantify toxic death, adverse events (AEs) and treatment discontinuation due to AEs from checkpoint inhibitors (CI). METHODS: We searched for randomized trials with adequate reporting for toxicity outcomes. Pooled risk ratios were estimated for CI versus chemotherapy or different combinations of these agents. RESULTS: Twenty trials of five different cancers with 10 794 patients with performance status 0 or 1 were identified...
January 19, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29349793/the-effectiveness-and-safety-of-ledipasvir-plus-sofosbuvir-in-adolescents-with-chronic-hepatitis-c-virus-genotype-4-infection-a-real-world-experience
#4
H R El-Khayat, E M Kamal, M H El-Sayed, M El-Shabrawi, H Ayoub, A RizK, M Maher, R Y El Sheemy, Y M Fouad, D Attia
BACKGROUND: The combination of ledipasvir plus sofosbuvir was recently approved for treatment of adolescent (12-17 years) HCV genotype 1, 4, 5 & 6 patients. However, few clinical trials have been performed in genotype 1 patients. AIM: To investigate the effectiveness and safety of ledipasvir plus sofosbuvir in chronic HCV adolescent patients with genotype 4 in the real world. METHODS: This prospective multicentre (six centres) open-label study included 144 adolescent chronic HCV patients with genotype 4 (mean age 14 ± 2, 69% males)...
January 19, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29349693/anti-tumor-necrosis-factor-%C3%AE-induced-dermatological-complications-in-a-large-cohort-of-inflammatory-bowel-disease-patients
#5
P Andrade, S Lopes, R Gaspar, A Nunes, S Magina, G Macedo
BACKGROUND/AIMS: The broader use of anti-tumor necrosis factor (TNF) agents in inflammatory bowel disease (IBD) has been associated with a high rate of adverse reactions. Dermatological complications are among the most common adverse events. We assessed the incidence, risk factors, management, and outcome of anti-TNF-induced dermatological complications in a large cohort of IBD patients. METHODS: This was an observational retrospective study at a single tertiary referral center...
January 18, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29349592/overview-of-current-and-future-adjuvant-therapy-for-high-risk-localized-renal-cell-carcinoma
#6
REVIEW
Lakshminarayanan Nandagopal, Gurudatta Naik, Guru Sonpavde
High-risk localized renal cell carcinoma represents a therapeutic challenge with high recurrence rates and poor survival with nephrectomy alone. Multiple agents targeting angiogenic and immunologic pathways have demonstrated remarkable efficacy in the metastatic setting but have failed to replicate similar successes in localized disease. Study results with adjuvant anti-angiogenic therapies may have been compromised by the high incidence of treatment discontinuations or dosage reductions secondary to intolerable side effects...
January 18, 2018: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/29349545/risk-of-discontinuation-of-clopidogrel-after-1-month-following-bare-metal-stents-a-propensity-score-adjusted-comparison-with-continued-administration-of-clopidogrel-after-drug-eluting-stents
#7
Christian M Valina, Sebastian Merz, Nikolaus Löffelhardt, Michael Amann, Miroslaw Ferenc, Christian Stratz, Franz-Josef Neumann, Willibald Hochholzer
In patients at high risk for bleeding undergoing percutaneous coronary intervention (PCI) the use of bare-metal-stent (BMS) is considered an option that allows discontinuation of clopidogrel after 4 weeks. We sought to investigate the risk of early discontinuation of clopidogrel in patients with BMS as compared with a 6-month course of clopidogrel after DES in patients with or without high on-treatment platelet reactivity (HTPR). In 765 consecutive patients undergoing PCI after loading with clopidogrel 600 mg, HTPR was tested by optical aggregometry and defined as residual platelet reactivity > 14%...
January 18, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29349356/qt-interval-prolongation-due-to-medication-found-in-the-preoperative-evaluation
#8
Mika Seto, Sayo Koga, Ryosuke Kita, Toshihiro Kikuta
QT prolongation is an electrocardiographic change that can lead to lethal arrhythmia. Acquired QT prolongation is known to be caused by drugs and electrolyte abnormalities. We report three cases in which the prolonged QT interval was improved at the time of operation by briefly discontinuing the drugs suspected to have caused the QT prolongation observed on preoperative electrocardiography. The QTc of cases 1, 2, and 3 improved from 518 to 429 ms, 463 to 441 ms, and 473 to 443 ms on discontinuing the use of a gastrointestinal prokinetic agent, a proton pump inhibitor, and a molecular targeted drug, respectively...
December 2017: Journal of Dental Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29348711/efficacy-of-empirical-therapy-with-combined-ciprofloxacin-versus-topical-drops-alone-in-patients-with-tubotympanic-chronic-suppurative-otitis-media-a-randomized-double-blind-controlled-trial
#9
Maisam Abbas Onali, Syeda Beenish Bareeqa, Sadaf Zia, Syed Ijlal Ahmed, Asneha Owais, Ahmad Nawaz Ahmad
Background: One of the prevailing otologic infections in our country is chronic suppurative otitis media, especially the tubotympanic type for which various treatment protocols are followed. Usually, oral and topical antibiotics (mainly quinolones) are given alone or in combination. There is a lack of consensus as to whether topical drops alone are effective or a combined oral and systemic therapy should be prescribed. In our study, we have attempted to observe the efficacy of empirical therapy with combined ciprofloxacin versus topical drops only in patients with tubotympanic chronic suppurative otitis media for control of infection...
2018: Clinical Medicine Insights. Ear, Nose and Throat
https://www.readbyqxmd.com/read/29348274/sinogenic-intracranial-complications-is-adalimumab-a-culprit
#10
Mikkel Seremet Kofoed, Niels Fisker, Anne Estmann Christensen, Anette Drøhse Kjeldsen
We present two 11-year-old girls with chronic recurrent multifocal osteomyelitis, treated with adalimumab. Both developed severe intracranial complications to sinusitis. Patient 1 had been treated with adalimumab for 15 months when she developed acute sinusitis complicated by an orbital abscess, forehead swelling, a subdural empyema and osteomyelitis of the frontal bone. She was treated with a rhinosurgical and neurosurgical approach with intravenous antibiotics.Patient 2 had been in adalimumab treatment for 10 weeks...
January 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29348123/rash-associated-with-rivaroxaban-use
#11
Kelly M Rudd, Narmadha Panneerselvam, Anush Patel
PURPOSE: A case of a patient who developed a hypersensitivity reaction to rivaroxaban in the form of a diffuse, exanthematous rash is reported. SUMMARY: After starting rivaroxaban for treatment of cancer-associated deep vein thrombosis (DVT) with pulmonary embolism (PE), a 69-year-old Caucasian woman arrived at an oncology clinic with a diffuse, exanthematous (morbilliform) rash on her neck and torso, spreading to her upper and lower extremities. She reported that the symptoms started to develop about 48 hours after transitioning from subcutaneous enoxaparin to oral rivaroxaban...
January 18, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29347785/discontinuous-fluidization-transition-in-time-correlated-assemblies-of-actively-deforming-particles
#12
Elsen Tjhung, Ludovic Berthier
Tracking experiments in dense biological tissues reveal a diversity of sources for local energy injection at the cell scale. The effect of cell motility has been largely studied, but much less is known about the effect of the observed volume fluctuations of individual cells. We consider a microscopic model of "actively deforming" particles where local fluctuations of the particle size constitute a unique source of motion. We demonstrate that collective motion can emerge under the sole influence of such active volume fluctuations...
November 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347783/subjamming-transition-in-binary-sphere-mixtures
#13
Ishan Prasad, Christian Santangelo, Gregory Grason
We study the influence of particle-size asymmetry on structural evolution of randomly jammed binary sphere mixtures with varying large-sphere and small-sphere composition. Simulations of jammed packings are used to assess the transition from large-sphere dominant to small-sphere dominant mixtures. For weakly asymmetric particle sizes, packing properties evolve smoothly, but not monotonically, with increasing small-sphere composition, f. Our simulations reveal that at high values of ratio α of large- to small-sphere radii (α≥α_{c}≈5...
November 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347726/deceleration-of-one-dimensional-mixing-by-discontinuous-mappings
#14
Hannah Kreczak, Rob Sturman, Mark C T Wilson
We present a computational study of a simple one-dimensional map with dynamics composed of stretching, permutations of equally sized cells, and diffusion. We observe that the combination of the aforementioned dynamics results in eigenmodes with long-time exponential decay rates. The decay rate of the eigenmodes is shown to be dependent on the choice of permutation and changes nonmonotonically with the diffusion coefficient for many of the permutations. The global mixing rate of the map M in the limit of vanishing diffusivity approximates well the decay rates of the eigenmodes for small diffusivity, however this global mixing rate does not bound the rates for all values of the diffusion coefficient...
November 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347711/shock-wave-like-structures-induced-by-an-exothermic-neutralization-reaction-in-miscible-fluids
#15
Dmitry Bratsun, Alexey Mizev, Elena Mosheva, Konstantin Kostarev
We report shock-wave-like structures that are strikingly different from previously observed fingering instabilities, which occur in a two-layer system of miscible fluids reacting by a second-order reaction A+B→S in a vertical Hele-Shaw cell. While the traditional analysis expects the occurrence of a diffusion-controlled convection, we show both experimentally and theoretically that the exothermic neutralization reaction can also trigger a wave with a perfectly planar front and nearly discontinuous change in density across the front...
November 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347694/constraint-percolation-on-hyperbolic-lattices
#16
Jorge H Lopez, J M Schwarz
Hyperbolic lattices interpolate between finite-dimensional lattices and Bethe lattices, and they are interesting in their own right, with ordinary percolation exhibiting not one but two phase transitions. We study four constraint percolation models-k-core percolation (for k=1,2,3) and force-balance percolation-on several tessellations of the hyperbolic plane. By comparing these four different models, our numerical data suggest that all of the k-core models, even for k=3, exhibit behavior similar to ordinary percolation, while the force-balance percolation transition is discontinuous...
November 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347617/force-percolation-transition-of-jammed-granular-systems
#17
Sudhir N Pathak, Valentina Esposito, Antonio Coniglio, Massimo Pica Ciamarra
The mechanical and transport properties of jammed materials originate from an underlying percolating network of contact forces between the grains. Using extensive simulations we investigate the force-percolation transition of this network, where two particles are considered as linked if their interparticle force overcomes a threshold. We show that this transition belongs to the random percolation universality class, thus ruling out the existence of long-range correlations between the forces. Through a combined size and pressure scaling for the percolative quantities, we show that the continuous force percolation transition evolves into the discontinuous jamming transition in the zero pressure limit, as the size of the critical region scales with the pressure...
October 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347575/critical-phenomena-of-a-hybrid-phase-transition-in-cluster-merging-dynamics
#18
K Choi, Deokjae Lee, Y S Cho, J C Thiele, H J Herrmann, B Kahng
Recently, a hybrid percolation transition (HPT) that exhibits both a discontinuous transition and critical behavior at the same transition point has been observed in diverse complex systems. While the HPT induced by avalanche dynamics has been studied extensively, the HPT induced by cluster merging dynamics (HPT-CMD) has received little attention. Here, we aim to develop a theoretical framework for the HPT-CMD. We find that two correlation-length exponents are necessary for characterizing the giant cluster and finite clusters separately...
October 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347493/kinetic-theory-of-shear-thickening-for-a-moderately-dense-gas-solid-suspension-from-discontinuous-thickening-to-continuous-thickening
#19
Hisao Hayakawa, Satoshi Takada, Vicente Garzó
The Enskog kinetic theory for moderately dense gas-solid suspensions under simple shear flow is considered as a model to analyze the rheological properties of the system. The influence of the environmental fluid on solid particles is modeled via a viscous drag force plus a stochastic Langevin-like term. The Enskog equation is solved by means of two independent but complementary routes: (i) Grad's moment method and (ii) event-driven Langevin simulation of hard spheres. Both approaches clearly show that the flow curve (stress-strain rate relation) depends significantly on the volume fraction of the solid particles...
October 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347484/partial-inertia-induces-additional-phase-transition-in-the-majority-vote-model
#20
Pedro E Harunari, M M de Oliveira, C E Fiore
Explosive (i.e., discontinuous) transitions have aroused great interest by manifesting in distinct systems, such as synchronization in coupled oscillators, percolation regime, absorbing phase transitions, and more recently, the majority-vote model with inertia. In the latter, the model rules are slightly modified by the inclusion of a term depending on the local spin (an inertial term). In such a case, Chen et al. [Phys Rev. E 95, 042304 (2017)2470-004510.1103/PhysRevE.95.042304] have found that relevant inertia changes the nature of the phase transition in complex networks, from continuous to discontinuous...
October 2017: Physical Review. E
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