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meningococcal review

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https://www.readbyqxmd.com/read/28633281/the-sweet-side-of-the-pathogenic-neisseria-the-role-of-glycan-interactions-in-colonisation-and-disease
#1
Tsitsi D Mubaiwa, Evgeny A Semchenko, Lauren E Hartley-Tassell, Christopher J Day, Michael P Jennings, Kate L Seib
Glycomics is a rapidly growing field that focuses on the structure and function of carbohydrates (glycans) in biological systems. Glycan interactions play a major role in infectious disease, at all stages of colonisation and disease progression. Neisseria meningitidis, the cause of meningococcal sepsis and meningitis, and Neisseria gonorrhoeae, which causes the sexually transmitted infection gonorrhoea, are responsible for significant morbidity and mortality worldwide. N. meningitidis displays a range of surface glycosylations including capsule polysaccharide, lipooligosaccharide and O-linked glycoproteins...
June 13, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28613408/pre-admission-antibiotics-for-suspected-cases-of-meningococcal-disease
#2
REVIEW
Thambu D Sudarsanam, Priscilla Rupali, Prathap Tharyan, Ooriapadickal Cherian Abraham, Kurien Thomas
BACKGROUND: Meningococcal disease can lead to death or disability within hours after onset. Pre-admission antibiotics aim to reduce the risk of serious disease and death by preventing delays in starting therapy before confirmation of the diagnosis. OBJECTIVES: To study the effectiveness and safety of pre-admission antibiotics versus no pre-admission antibiotics or placebo, and different pre-admission antibiotic regimens in decreasing mortality, clinical failure, and morbidity in people suspected of meningococcal disease...
June 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28557577/the-next-chapter-for-group-b-meningococcal-vaccines
#3
N Y Wang, A J Pollard
The majority of invasive meningococcal disease (IMD) in the developed world is caused by capsular group B Neisseria meningitidis, however success with vaccination against organisms bearing this capsule has previously been restricted to control of geographically limited clonal outbreaks. As we enter a new era, with the first routine program underway to control endemic group B meningococcal disease for infants in the UK, it is timely to review the key landmarks in group B vaccine development, and discuss the issues determining whether control of endemic group B disease will be achieved...
May 30, 2017: Critical Reviews in Microbiology
https://www.readbyqxmd.com/read/28524748/an-unwanted-guest-neisseria-meningitidis-carriage-risk-for-invasive-disease-and-the-impact-of-vaccination-with-insight-on-italy-incidence
#4
Elena Gianchecchi, Giulia Piccini, Alessandro Torelli, Rino Rappuoli, Emanuele Montomoli
Invasive Meningococcal Disease (IMD) represents a potentially life-threatening condition caused by Neisseria meningitidis. The disease is characterized by a case fatality rate of 5-10% whereas serious clinical sequelae can develop in survivors within 12-24 h from the first symptoms. However, IMD infection only occurs rarely, in fact, most of the interactions established between N. meningitidis and the host are harmless, and an estimated 10% of the population asymptomatically carries the bacterium in the nasopharynx...
May 29, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28505234/increased-risk-for-meningococcal-disease-among-men-who-have-sex-with-men-in-the-united-states-2012-2015
#5
Temitope A Folaranmi, Cecilia B Kretz, Hajime Kamiya, Jessica R MacNeil, Melissa J Whaley, Amy Blain, Mike Antwi, Marie Dorsinville, Massimo Pacilli, Shamika Smith, Rachel Civen, Van Ngo, Kathleen Winter, Kathleen Harriman, Xin Wang, Virginia B Bowen, Manisha Patel, Stacey Martin, Lara Misegades, Sarah A Meyer
Background: Several clusters of serogroup C meningococcal disease among men who have sex with men (MSM) have been reported in the United States in recent years. The epidemiology and risk of meningococcal disease among MSM is not well-described. Methods: All meningococcal disease cases among men aged 18-64 years reported to the National Notifiable Disease Surveillance System between January 2012 and June 2015 were reviewed. Characteristics of meningococcal disease cases among MSM and men not known to be MSM (non-MSM) were described...
May 13, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28498097/the-asplenic-patient-post-insult-immunocompetence-infection-and-vaccination
#6
Brandon Dionne, Walter Dehority, Meghan Brett, Thomas R Howdieshell
BACKGROUND: Splenic injury can occur through multiple mechanisms and may result in various degrees of residual immunocompetence. Functionally or anatomically asplenic patients are at higher risk for infection, particularly with encapsulated bacteria. Vaccination is recommended to prevent infection with these organisms; however, the recommendations are routinely updated, and vaccine selection and timing are complex. METHODS: Review of the pertinent English-language literature, including the recommendations of the U...
May 12, 2017: Surgical Infections
https://www.readbyqxmd.com/read/28487799/primary-meningococcal-type-c-arthritis-a-case-report-and-literature-review
#7
Maximiliano Barahona, Jaime Catalan, Yoshiro Sato, Jaime Hinzpeter
Acute septic arthritis is a common clinical problem in emergency departments. Primary meningococcal arthritis (PMA) is very rare and few cases are reported in literature. D. B. M. consulted the emergency department for knee pain and fever; analysis showed that the cause was a Neisseria meningitidis type C infection. He received a treatment consisting of 2 arthroscopies and 5 weeks of antibiotics. At five weeks he returned to work and at 2 months he resumed sports (jogging and soccer) without complaints. Primary arthritis of the knee caused by Neisseria meningitidis is very rare...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/28487177/predicted-vs-observed-effectiveness-of-outer-membrane-vesicle-omv-vaccines-against-meningococcal-serogroup-b-disease-systematic-review
#8
Thomas Harder, Judith Koch, Ole Wichmann, Wiebke Hellenbrand
IMPORTANCE: Human serum bactericidal antibody levels (hSBA) are commonly used as an immune correlate of protection after vaccination against meningococcal disease. We performed a systematic review of how well this marker correlates with protection induced by outer membrane vesicle (OMV) vaccines against meningococcal B (MenB) disease. OBJECTIVE: To compare vaccine effectiveness (VE) of OMV vaccines against MenB predicted by hSBA (predicted protection) to VE from clinical studies (observed protection)...
May 6, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28478773/clinical-presentation-of-invasive-disease-caused-by-neisseria-meningitidis-serogroup-y-in-sweden-1995-to-2012
#9
O Säll, B Stenmark, M Glimåker, S Jacobsson, P Mölling, P Olcén, H Fredlund
Over the period 1995-2012, the incidence of invasive meningococcal disease (IMD) caused by Neisseria meningitidis serogroup Y (NmY) increased significantly in Sweden. This is mainly due to the emergence of a predominant cluster named strain type YI subtype 1, belonging to the ST-23 clonal complex (cc). The aim of this study was to examine the clinical picture of patients with invasive disease caused by NmY and to analyse whether the predominant cluster exhibits certain clinical characteristics that might explain the increased incidence...
May 8, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28474295/individual-preferences-for-child-and-adolescent-vaccine-attributes-a-systematic-review-of-the-stated-preference-literature
#10
REVIEW
Christine Michaels-Igbokwe, Shannon MacDonald, Gillian R Currie
BACKGROUND: Discrete choice experiments are increasingly used to assess preferences for vaccines and vaccine service delivery. OBJECTIVES: To synthesize and critically assess the application of discrete choice experiments in childhood/adolescent vaccines, to describe how discrete choice experiments have been applied to understand preferences, and to evaluate the use of discrete choice experiment data to inform estimates of vaccine uptake. METHODS: We conducted a systematic review of six electronic databases...
May 4, 2017: Patient
https://www.readbyqxmd.com/read/28455205/meningococcal-disease-in-the-middle-east-and-africa-findings-and-updates-from-the-global-meningococcal-initiative
#11
REVIEW
Ray Borrow, Dominique A Caugant, Mehmet Ceyhan, Hannah Christensen, Ener Cagri Dinleyici, Jamie Findlow, Linda Glennie, Anne Von Gottberg, Amel Kechrid, Julio Vázquez Moreno, Aziza Razki, Vincent Smith, Muhamed-Kheir Taha, Hassiba Tali-Maamar, Khalid Zerouali
The Global Meningococcal Initiative (GMI) has recently considered current issues in Middle Eastern and African countries, and produced two recommendations: (i) that vaccination of attendees should be considered for some types of mass-gathering events, as some countries mandate for the Hajj, and (ii) vaccination of people with human immunodeficiency virus should be used routinely, because of increased meningococcal disease (MD) risk. Differences exist between Middle Eastern and African countries regarding case and syndrome definitions, surveillance, and epidemiologic data gaps...
April 25, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28448733/endogenous-meningococcal-endophthalmitis-with-isolated-joint-involvement-in-immunocompetent-adults
#12
Vishal Shah, Anurag Garg, Miles Stanford
PURPOSE: We report two cases of endogenous meningococcal endophthalmitis in immunocompetent adults presenting with unilateral ocular disease and joint involvement. METHODS: A retrospective review of two patients with endogenous endophthalmitis due to Neisseria meningitidis with associated arthropathy was conducted. The clinical presentation, investigations, treatment, and outcomes are presented. RESULTS: Vitreous sampling confirmed Neisseria meningitidis via polymerase chain reaction (PCR) in both cases...
April 27, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28375029/emerging-experience-with-meningococcal-serogroup-b-protein-vaccines
#13
REVIEW
Daniela Toneatto, Mariagrazia Pizza, Vega Masignani, Rino Rappuoli
The successful development of two broadly protective vaccines targeting Neisseria meningitidis serogroup B (MenB); 4CMenB and rLP2086, is the most significant recent advance in meningococcal disease prevention. Areas covered: Here we review the principles underlying the development of each vaccine and the novel methods used to estimate vaccine coverage. We update clinical and post-licensure experience with 4CMenB and rLP2086. Expert commentary: The immunogenicity and acceptable safety profile of 4CMenB and rLP2086 has been demonstrated in clinical trials...
May 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28369428/novel-approaches-to-neisseria-meningitidis-vaccine-design
#14
Myron Christodoulides, John Heckels
A range of vaccines is available for preventing life-threatening diseases caused by infection with Neisseria meningitidis (meningococcus, Men). Capsule polysaccharide (CPS)-conjugate vaccines are successful prophylactics for serogroup MenA, MenC, MenW and MenY infections and outer membrane vesicle (OMV) vaccines have been used successfully for controlling clonal serogroup MenB infections. MenB vaccines based on recombinant proteins identified by reverse vaccinology (Bexsero®) and proteomics (Trumenba®) approaches have recently been licensed and Bexsero® has been introduced into the UK infant immunization program...
March 22, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28334397/does-post-implementation-vaccine-effectiveness-data-support-pre-implementation-predictions-of-4cmenb-utility
#15
REVIEW
Jamie Findlow, Ray Borrow
Meningococcal serogroup B vaccines have been licensed on the basis of safety and immunogenicity data without efficacy studies. Establishing the breadth of coverage of these new vaccines has proved difficult and relied on correlates of protection such as serum bactericidal antibody and a novel assays such as the meningococcal antigen typing system. The demonstration of the effectiveness of 4CMenB in a reduced infant dose schedule together with detailed phenotypic and genotypic information gained from isolates and sera from cases of invasive MenB disease in vaccine eligible infants will enable a re-evaluation of our knowledge of correlates of protection...
March 1, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28334263/pathogenesis-of-meningococcal-purpura-fulminans
#16
REVIEW
Hervé Lécuyer, Delphine Borgel, Xavier Nassif, Mathieu Coureuil
Purpura fulminans (PF) is a dreadful and frequent complication of Neisseria meningitidis invasive infection, and is associated with a high mortality rate. This syndrome begins with dermal microvessels thrombosis that rapidly lead to hemorrhagic skin necrosis. In this review, we discuss the prothrombotic events occurring during meningococcal infection. Moreover, recent data from an experimental mouse model have highlighted the critical role of the meningococcus adhesion to the endothelium in the development of PF lesions, thus opening new therapeutic perspectives...
April 1, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28270154/pandemics-pathogenicity-and-changing-molecular-epidemiology-of-cholera-in-the-era-of-global-warming
#17
REVIEW
Fazle Rabbi Chowdhury, Zannatun Nur, Nazia Hassan, Lorenz von Seidlein, Susanna Dunachie
BACKGROUND: Vibrio cholerae, a Gram-negative, non-spore forming curved rod is found in diverse aquatic ecosystems around the planet. It is classified according to its major surface antigen into around 206 serogroups, of which O1 and O139 cause epidemic cholera. A recent spatial modelling technique estimated that around 2.86 million cholera cases occur globally every year, and of them approximately 95,000 die. About 1.3 billion people are currently at risk of infection from cholera. Meta-analysis and mathematical modelling have demonstrated that due to global warming the burden of vector-borne diseases like malaria, leishmaniasis, meningococcal meningitis, viral encephalitis, dengue and chikungunya will increase in the coming years in the tropics and beyond...
March 7, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28262331/adverse-events-following-quadrivalent-meningococcal-crm-conjugate-vaccine-menveo%C3%A2-reported-to-the-vaccine-adverse-event-reporting-system-vaers-2010-2015
#18
Tanya R Myers, Michael M McNeil, Carmen S Ng, Rongxia Li, Paige W Lewis, Maria V Cano
BACKGROUND: Limited data are available describing the post-licensure safety of meningococcal vaccines, including Menveo®. We reviewed reports of adverse events (AEs) to the Vaccine Adverse Event Reporting System (VAERS) to assess safety in all age groups. METHODS: VAERS is a national spontaneous vaccine safety surveillance system co-administered by the Centers for Disease Control and Prevention and the US Food and Drug Administration. We searched the VAERS database for US reports of adverse events in persons who received Menveo from 1 January 2010 through 31 December 2015...
March 27, 2017: Vaccine
https://www.readbyqxmd.com/read/28185740/vaccine-adverse-events-in-a-safety-net-healthcare-system-and-a-managed-care-organization
#19
Komal J Narwaney, Kristin Breslin, Colleen A Ross, Jo Ann Shoup, Kris F Wain, Eric S Weintraub, Michael M McNeil, Simon J Hambidge
BACKGROUND: The Institute of Medicine, in a 2013 report, recommended that the Vaccine Safety Datalink (VSD) expand collaborations to include more diversity in the study population. Kaiser Permanente Colorado (KPCO), an established VSD site, partnered with Denver Health (DH), an integrated safety net healthcare system, to demonstrate the feasibility of integrating DH data within the VSD. Prior to incorporating the data, we examined the identification of specific vaccine associated adverse events (VAEs) in these two distinct healthcare systems...
February 6, 2017: Vaccine
https://www.readbyqxmd.com/read/28167517/the-need-to-optimize-adolescent-immunization
#20
Henry H Bernstein, Joseph A Bocchini
The adolescent period heralds the pediatric patient's transition into adulthood. It is a time of dynamic development during which effective preventive care measures can promote safe behaviors and the development of lifelong health habits. One of the foundations of preventive adolescent health care is timely vaccination, and every visit can be viewed as an opportunity to update and complete an adolescent's immunizations.In the past decade, the adolescent immunization schedule has expanded to include 2 doses of quadrivalent meningococcal conjugate vaccine, 1 dose of tetanus, diphtheria, acellular pertussis, absorbed vaccine, 2 or 3 doses of human papillomavirus vaccine, depending on the child's age, and an annual influenza vaccine...
March 2017: Pediatrics
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