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https://www.readbyqxmd.com/read/28933621/neisseria-meningitidis-serogroup-x-st-5799-st-22-complex-in-turkey-a-unique-pediatric-case
#1
Gönül Tanır, Yasemin Ozsurekci, Jay Lucidarme, Sevgi Yaşar Durmuş, Aiswarya Lekshmi, Özlem Akisoglu, Ahmet Emre Aycan, Ray Borrow, Mehmet Ceyhan
Although outbreaks of Neisseria meningitidis serogroup X occured in a couple of African countries, a limited number of serogroup X meningococcal cases were reported in America and Europe as well as Turkey. Additionally, serogroup X is still not represented in current conjugated meningococcal vaccines. Here, we describe the first pediatric case with meningitis caused by Neisseria meningitidis serogroup X ST-5799 (ST-22 complex) that formed a distinct lineage.
September 21, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28912442/the-association-between-respiratory-tract-infection-incidence-and-localised-meningitis-epidemics-an-analysis-of-high-resolution-surveillance-data-from-burkina-faso
#2
Judith E Mueller, Maxime Woringer, Souleymane Porgho, Yoann Madec, Haoua Tall, Nadège Martiny, Brice W Bicaba
Meningococcal meningitis epidemics in the African meningitis belt consist of localised meningitis epidemics (LME) that reach attack proportions of 1% within a few weeks. A meningococcal serogroup A conjugate vaccine was introduced in meningitis belt countries from 2010 on, but LME due to other serogroups continue to occur. The mechanisms underlying LME are poorly understood, but an association with respiratory pathogens has been hypothesised. We analysed national routine surveillance data in high spatial resolution (health centre level) from 13 districts in Burkina Faso, 2004-2014...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28904187/genomic-characterization-of-urethritis-associated-neisseria-meningitidis-shows-that-a-wide-range-of-n-meningitidis-strains-can-cause-urethritis
#3
Kevin C Ma, Magnus Unemo, Samo Jeverica, Robert D Kirkcaldy, Hideyuki Takahashi, Makoto Ohnishi, Yonatan H Grad
Neisseria meningitidis, typically a resident of the oro- or nasopharynx and the causative agent of meningococcal meningitis and meningococcemia, is capable of invading and colonizing the urogenital tract. This can result in urethritis, akin to the syndrome caused by its sister species N. gonorrhoeae, the etiologic agent of gonorrhea. Recently, meningococcal strains associated with outbreaks of urethritis were reported to share genetic characteristics with gonococcus, raising the question of the extent to which these strains contain features that promote adaptation to the genitourinary niche, making them gonococcal-like and distinguishing them from other N...
September 13, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28892991/neisseria-meningitidis-causing-multiple-cerebral-abscesses-in-early-neonatal-period-case-report-and-review-of-literature
#4
Laxman Basani, Roja Aepala
Neisseria meningitidis is a rare cause of meningitis and septicemia in neonates. There are few published case reports of neonatal meningococcal meningitis complicated by subdural empyema, cerebral abscess and hydrocephalus. Few cases of neonatal meningococcal meningitis have been reported in the literature with none of them having the complication of multiple cerebral abscesses in early neonatal period (<seven days of life). We report a case of meningococcal meningitis with multiple cerebral abscesses which presented on fifth day of life and developed hydrocephalus at five weeks of life requiring a Ventriculo Peritoneal (VP) shunt...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28813690/deep-coal-mining-and-meningococcal-meningitis-in-england-and-wales-1931-38-ecological-study-with-implications-for-deep-shaft-mining-activities-worldwide
#5
Matthew R Smallman-Raynor, Andrew D Cliff
The hypothesized role of deep coal mining in the development of community-based outbreaks of meningococcal meningitis has gone largely unexplored. Taking the coalfields of Britain as a historical testbed, techniques of linear and binomial logistic regression were used to assess the association between meningococcal meningitis rates and male occupation rates for coal mining in England and Wales during the national epidemic of 1931-32 and in its aftermath. Adjusting for the epidemiological effects of age, residential density, recent changes in the number of families, housing stock and low social class, the analysis yielded evidence of a significant and positive association between coal mining occupation rates and notified levels of meningitis activity in the epidemic period...
September 2017: Health & Place
https://www.readbyqxmd.com/read/28801740/a-statistical-classifier-to-support-diagnose-meningitis-in-less-developed-areas-of-brazil
#6
Viviane-Maria Lélis, Eduardo Guzmán, María-Victoria Belmonte
This paper describes the development of statistical classifiers to help diagnose meningococcal meningitis, i.e. the most sever, infectious and deadliest type of this disease. The goal is to find a mechanism able to determine whether a patient has this type of meningitis from a set of symptoms that can be directly observed in the earliest stages of this pathology. Currently, in Brazil, a country that is heavily affected by meningitis, all suspected cases require immediate hospitalization and the beginning of a treatment with invasive tests and medicines...
August 11, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28796795/investigation-of-correlates-of-protection-against-pharyngeal-carriage-of-neisseria-meningitidis-genogroups-w-and-y-in-the-african-meningitis-belt
#7
Laura V Cooper, Rahamatou Moustapha Boukary, Abraham Aseffa, Wude Mihret, Jean-Marc Collard, Doumagoum Daugla, Abraham Hodgson, Cheikh Sokhna, Babatunji Omotara, Samba Sow, Stephen Laryea Quaye, Kanny Diallo, Olivier Manigart, Martin C J Maiden, Helen Findlow, Ray Borrow, James M Stuart, Brian M Greenwood, Caroline L Trotter
BACKGROUND: Serum bactericidal antibody titres that correlate with protection against invasive meningococcal disease have been characterised. However, titres that are associated with protection against acquisition of pharyngeal carriage of Neisseria meningitidis are not known. METHODS: Sera were obtained from the members of a household in seven countries of the African meningitis belt in which a pharyngeal carrier of N. meningitidis had been identified during a cross-sectional survey...
2017: PloS One
https://www.readbyqxmd.com/read/28771457/meningitis-outbreak-caused-by-vaccine-preventable-bacterial-pathogens-northern-ghana-2016
#8
Fortress Y Aku, Fernanda C Lessa, Franklin Asiedu-Bekoe, Phoebe Balagumyetime, Winfred Ofosu, Jennifer Farrar, Mahamoudou Ouattara, Jeni T Vuong, Kofi Issah, Joseph Opare, Sally-Ann Ohene, Charles Okot, Ernest Kenu, Donne K Ameme, David Opare, Abass Abdul-Karim
Bacterial meningitis is a severe, acute infection of the fluid surrounding the brain and spinal cord that can rapidly lead to death. Even with recommended antibiotic treatment, up to 25% of infected persons in Africa might experience neurologic sequelae (1). Three regions in northern Ghana (Upper East, Northern, and Upper West), located in the sub-Saharan "meningitis belt" that extends from Senegal to Ethiopia, experienced periodic outbreaks of meningitis before introduction of serogroup A meningococcal conjugate vaccine (MenAfriVac) in 2012 (2,3)...
August 4, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28770496/serogroup-b-meningococcus-outbreaks-prevalence-and-the-case-for-standard-vaccination
#9
REVIEW
James Grogan, Karen Roos
PURPOSE OF REVIEW: This review explores the history of serogroup B meningitis outbreaks in American universities and the rise of the monovalent serogroup B meningococcus vaccines (MenB). RECENT FINDINGS: Serogroup B meningitis represents 30% of American meningococcal infections and had no commercially available vaccine in the USA until 2013 when the FDA made an expanded allowance for importation of the MenB-4C vaccine for outbreaks at two American universities. Infections of Neisseria meningitidis, notably meningococcal meningitis represent a continued, lethal threat to the pediatric and adolescent populations and those with primary or acquired complement component deficiencies, largely mitigated by the quadrivalent meningococcal conjugated vaccine against serogroups A, C, W, and Y (MenACWY)...
September 2017: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/28767667/uptake-of-a-new-meningitis-vaccination-programme-amongst-first-year-undergraduate-students-in-the-united-kingdom-a-cross-sectional-study
#10
Sarah Blagden, Daniel Seddon, Daniel Hungerford, Debbi Stanistreet
BACKGROUND: In 2015 meningococcal group W was declared endemic in the UK, with the meningococcal ACWY vaccination (MenACWY) subsequently introduced amongst adolescents and first-year university students. This study aimed to determine MenACWY uptake amongst students and to evaluate how this was influenced by demographics and via the Health Belief Model (HBM). METHODS: This was a cross-sectional study conducted at a British university amongst first-year undergraduate students aged 18-25 years...
2017: PloS One
https://www.readbyqxmd.com/read/28760613/who-position-paper-meningococcal-a-conjugate-vaccine-updated-guidance-february-2015
#11
World Health Organization
This article presents the World Health Organization's (WHO) updated recommendations on the use of meningococcal vaccines excerpted from the WHO position paper on Meningococcal A conjugate vaccine: updated guidance, February 2015, published in the Weekly Epidemiological Record [1]. A position paper on meningococcal vaccines was published in 2011 and its recommendations remain valid [2]. This update adds to the previous recommendations specifically concerning routine immunization of infants and young children in the African meningitis belt with meningococcal A conjugate vaccine...
July 28, 2017: Vaccine
https://www.readbyqxmd.com/read/28745253/-gastrointestinal-symptoms-with-meningococcal-infection-emergence-of-neisseria-meningitidis-serogroup-w
#12
H F Wunderink, I N Vlasveld, M J Knol, A van der Ende, E H R van Essen, E J Kuijper
BACKGROUND: Meningococcal disease usually presents as meningitis and/or septicaemia, but can also present as pneumonia or arthritis. Since 2000, a worldwide increase in meningococcal disease is reported which is caused by a new virulent clone of serogroup W (MenW:cc11). This subtype is more likely to give an atypical clinical presentation and results in high mortality rates. CASE DESCRIPTION: A 68-year-old woman with polymyalgia rheumatica, managed with prednisone, developed an acute gastrointestinal syndrome of nausea, diarrhoea, vomiting, fever and chills...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28739825/neisseria-cinerea-expresses-a-functional-factor-h-binding-protein-which-is-recognised-by-immune-responses-elicited-by-meningococcal-vaccines
#13
Hayley Lavender, Katy Poncin, Christoph M Tang
Neisseria meningitidis is a major cause of bacterial meningitis and sepsis worldwide. Capsular polysaccharide vaccines are available against meningococcal serogroups A, C, W and Y. More recently two protein based vaccines, Bexsero® and Trumenba®, have been licenced against meningococcal serogroup B strains; both vaccines contain meningococcal factor H binding protein (fHbp). fHbp is a surface exposed lipoprotein which binds the negative complement regulator, complement factor H (CFH), thereby inhibiting the alternative pathway of complement activation...
July 24, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28728477/increased-rate-of-penicillin-non-susceptible-strains-of-n-meningitidis-in-naples-italy
#14
Giovanni Di Caprio, Novella Carannante, Mariano Bernardo, Susanna Cuccurullo, Carlo Pallotto, Carlo Tascini
Neisseria meningitidis is a causative agent of community-acquired sepsis and meningitis in humans. These diseases are associated with high mortality and morbidity if treatment is not started promptly. The empiric antibiotic treatment depends on patient factors and local epidemiology. In the past years, an increased number meningococcal strain with reduced susceptibility to penicillin has also been described. We analysed the susceptibility pattern of 11 N. meningitidis strains isolated between 2013 and 2016...
July 20, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28723791/arthritis-secondary-to-meningococcal-disease-a-case-series-of-7-patients
#15
MULTICENTER STUDY
Vanina Masson-Behar, Hervé Jacquier, Pascal Richette, Jean-Marc Ziza, Valérie Zeller, Christophe Rioux, Baptiste Coustet, Philippe Dieudé, Sébastien Ottaviani
Arthritis secondary to invasive meningococcemia is rare and has been described as a direct result of bacteremia or as immunoallergic-type arthritis, related to the immune complex. Only a few case series have been reported.This multicenter study aimed to describe the clinical characteristics and therapeutic outcomes of arthritis secondary to meningococcal infection.We performed a 5-year retrospective study. We included all patients with inflammatory joint symptoms and proven meningococcal disease defined by the identification of Neisseria meningitidis in blood, cerebrospinal fluid, or synovial fluid...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28704569/a-virulence-associated-filamentous-bacteriophage-of-neisseria-meningitidis-increases-host-cell-colonisation
#16
Emmanuelle Bille, Julie Meyer, Anne Jamet, Daniel Euphrasie, Jean-Philippe Barnier, Terry Brissac, Anna Larsen, Philippe Pelissier, Xavier Nassif
Neisseria meningitidis is a commensal of human nasopharynx. In some circumstances, this bacteria can invade the bloodstream and, after crossing the blood brain barrier, the meninges. A filamentous phage, designated MDAΦ for Meningococcal Disease Associated, has been associated with invasive disease. In this work we show that the prophage is not associated with a higher virulence during the bloodstream phase of the disease. However, looking at the interaction of N. meningitidis with epithelial cells, a step essential for colonization of the nasopharynx, we demonstrate that the presence of the prophage, via the production of viruses, increases colonization of encapsulated meningococci onto monolayers of epithelial cells...
July 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28692384/advancing-the-use-of-emergency-department-syndromic-surveillance-data-new-york-city-2012-2016
#17
Ramona Lall, Jasmine Abdelnabi, Stephanie Ngai, Hilary B Parton, Kelly Saunders, Jessica Sell, Amanda Wahnich, Don Weiss, Robert W Mathes
INTRODUCTION: The use of syndromic surveillance has expanded from its initial purpose of bioterrorism detection. We present 6 use cases from New York City that demonstrate the value of syndromic surveillance for public health response and decision making across a broad range of health outcomes: synthetic cannabinoid drug use, heat-related illness, suspected meningococcal disease, medical needs after severe weather, asthma exacerbation after a building collapse, and Ebola-like illness in travelers returning from West Africa...
July 2017: Public Health Reports
https://www.readbyqxmd.com/read/28652113/early-versus-late-diagnosis-in-community-acquired-bacterial-meningitis-a-retrospective-cohort-study
#18
J Bodilsen, C T Brandt, A Sharew, M Dalager-Pedersen, T Benfield, H C Schønheyder, H Nielsen
OBJECTIVES: To examine clinical characteristics and outcome of patients with late diagnosis of community-acquired bacterial meningitis (CABM). METHODS: We conducted a chart review of all adults with proven CABM in three centres in Denmark from 1998 through to 2014. Patients were categorized as early diagnosis of CABM immediately on admission, or late diagnosis if CABM was not listed in referral or admission records and neither lumbar puncture nor antibiotic therapy for meningitis was considered immediately on admission...
June 24, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28651843/-neisseria%C3%A2-meningitidis-urethritis-two-case-reports
#19
C Dubois, A-L Liegeon, C Fabbro, F Truchetet
BACKGROUND: Neisseria meningitidis (NM) is a commensal bacteria present in the oropharyngeal flora that causes invasive infections. There have been rarer reports of presence in the genital region. Herein, we present two cases of acute NM urethritis. PATIENTS AND METHODS: Two men aged 30 and 31years, one of whom is homosexual and seropositive for HIV infection, presented urethral discharge which was diagnosed as acute urethritis. The unit through samples indicated the presence of NM of serogroups B and C...
June 23, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28646924/ciprofloxacin-for-contacts-of-cases-of-meningococcal-meningitis-as-an-epidemic-response-study-protocol-for-a-cluster-randomized-trial
#20
Matthew E Coldiron, Gabriel Alcoba, Iza Ciglenecki, Matt Hitchings, Ali Djibo, Anne-Laure Page, Celine Langendorf, Rebecca F Grais
BACKGROUND: Epidemics of meningococcal meningitis are common in the "African meningitis belt." Current response strategies include reactive vaccination campaigns, which are often organized too late to have maximal impact. A novel strain of Neisseria meningitidis serogroup C has been circulating in recent years, and vaccine supplies are limited. An evaluation of chemoprophylaxis with single-dose ciprofloxacin for household contacts of meningitis cases has therefore been recommended. METHODS/DESIGN: A three-arm cluster-randomized trial has been designed for implementation during a meningococcal meningitis epidemic in a health district in Niger in which at least two Health Zones (HZs) have met the weekly epidemic threshold...
June 24, 2017: Trials
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