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meningococcal meningitis

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https://www.readbyqxmd.com/read/29152576/meningococcal-antigen-typing-system-mats-based-neisseria-meningitidis-serogroup-b-coverage-prediction-for-the-menb-4c-vaccine-in-the-united-states
#1
Gowrisankar Rajam, Maria Stella, Ellie Kim, Simon Paulos, Giuseppe Boccadifuoco, Laura Serino, George Carlone, Duccio Medini
Neisseria meningitidis is the most common cause of bacterial meningitis in children and young adults worldwide. A 4-component vaccine against N. meningitidis serogroup B (MenB) disease (MenB-4C [Bexsero]; GSK) combining factor H binding protein (fHBP), neisserial heparin binding protein (NHBA), neisserial adhesin A (NadA), and PorA-containing outer membrane vesicles was recently approved for use in the United States and other countries worldwide. Because the public health impact of MenB-4C in the United States is unclear, we used the meningococcal antigen typing system (MATS) to assess the strain coverage in a panel of strains representative of serogroup B (NmB) disease in the United States...
November 2017: MSphere
https://www.readbyqxmd.com/read/29116892/lessons-from-the-meningitis-vaccine-project
#2
F Marc LaForce, Mamoudou Djingarey, Simonetta Viviani, Marie-Pierre Preziosi
From 2001 to 2017 the Meningitis Vaccine Project (MVP), a Gates Foundation funded partnership between PATH and the World Health Organization (WHO), successfully developed, tested, licensed, and introduced an affordable new Group A meningococcal conjugate vaccine, MenAfriVac(®), in sub-Saharan Africa. The vaccine was well received, and from 2010 to 2016, over 260 million Africans have received a dose of the vaccine in campaigns largely directed at 1-29-year olds. The public health impact has been dramatic with the elimination of Group A meningococcal infections wherever the vaccine has been used at public health scale...
November 8, 2017: Viral Immunology
https://www.readbyqxmd.com/read/29099305/peripheral-blood-vessels-are-a-niche-for-blood-borne-meningococci
#3
Elena Capel, Jean-Philippe Barnier, Aldert L Zomer, Christine Bole-Feysot, Thomas Nussbaumer, Anne Jamet, Hervé Lécuyer, Daniel Euphrasie, Zoé Virion, Eric Frapy, Philippe Pélissier, Olivier Join-Lambert, Thomas Rattei, Sandrine Bourdoulous, Xavier Nassif, Mathieu Coureuil
Neisseria meningitidis is the causative agent of cerebrospinal meningitis and that of a rapidly progressing fatal septic shock known as purpura fulminans. Meningococcemia is characterized by bacterial adhesion to human endothelial cells of the microvessels. Host specificity has hampered studies on the role of blood vessels colonization in N. meningitidis associated pathogenesis. In this work, using a humanized model of SCID mice allowing the study of bacterial adhesion to human cells in an in vivo context we demonstrate that meningococcal colonization of human blood vessels is a prerequisite to the establishment of sepsis and lethality...
November 3, 2017: Virulence
https://www.readbyqxmd.com/read/29095907/bacterial-meningitis-epidemiology-and-return-of-neisseria-meningitidis-serogroup-a-cases-in-burkina-faso-in-the-five-years-following-menafrivac-mass-vaccination-campaign
#4
Alpha Oumar Diallo, Heidi M Soeters, Issaka Yameogo, Guetawendé Sawadogo, Flavien Aké, Clément Lingani, Xin Wang, Andre Bita, Amadou Fall, Lassana Sangaré, Rasmata Ouédraogo-Traoré, Isaïe Medah, Brice Bicaba, Ryan T Novak
BACKGROUND: Historically, Neisseria meningitidis serogroup A (NmA) caused large meningitis epidemics in sub-Saharan Africa. In 2010, Burkina Faso became the first country to implement a national meningococcal serogroup A conjugate vaccine (MACV) campaign. We analyzed nationwide meningitis surveillance data from Burkina Faso for the 5 years following MACV introduction. METHODS: We examined Burkina Faso's aggregate reporting and national laboratory-confirmed case-based meningitis surveillance data from 2011-2015...
2017: PloS One
https://www.readbyqxmd.com/read/29068749/combined-effect-of-pcv10-and-meningococcal-c-conjugate-vaccination-on-meningitis-mortality-among-children-under-five-years-of-age-in-brazil
#5
Ana Luiza Bierrenbach, Ruth Minamisava, Airlane Pereira Alencar, Gizelton Pereira Alencar, Ana Lucia Andrade
The 10-valent pneumococcal conjugate vaccine (PCV10) was introduced in the Brazilian National Immunization Program in March 2010, scheduled at 2, 4, and 6 months, with a booster at 12-15 months of age. The meningococcal C conjugate vaccine (MCC) was introduced in November 2010, scheduled at 3 and 5 months, with a booster dose at 12-15 months of age and no catch-up for older age groups. In this interrupted time-series analysis study, we used Brazilian mortality data from 2005 to 2015 for children under five years of age (excluding data from the state of Bahia) to assess the combined impact of these vaccines on the overall burden of meningitis mortality among children aged 0-23 months and 2-4 years, as defined using meningitis and meningococcemia specific International Classification of Diseases - tenth revision codes...
October 25, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29064356/expansion-of-vaccination-services-and-strengthening-vaccine-preventable-diseases-surveillance-in-haiti-2010-2016
#6
Rania A Tohme, Jeannot Francois, Kathleen F Cavallaro, Gilson Paluku, Idrissa Yalcouye, Ernsley Jackson, Tracie Wright, Paul Adrien, Mark A Katz, Terri B Hyde, Pape Faye, Francine Kimanuka, Vance Dietz, John Vertefeuille, David Lowrance, Benjamin Dahl, Roopal Patel
Following the 2010 earthquake, Haiti was at heightened risk for vaccine-preventable diseases (VPDs) outbreaks due to the exacerbation of long-standing gaps in the vaccination program and subsequent risk of VPD importation from other countries. Therefore, partners supported the Haitian Ministry of Health and Population to improve vaccination services and VPD surveillance. During 2010-2016, three polio, measles, and rubella vaccination campaigns were implemented, achieving a coverage > 90% among children and maintaining Haiti free of those VPDs...
October 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29048988/developmental-strategy-for-a-new-group-a-meningococcalconjugate-vaccine-menafrivac-r
#7
Prasad S Kulkarni, Suresh S Jadhav, F Marc LaForce
Until recently, periodic Group A meningococcal meningitis outbreaks were a major public health problem in the sub-Saharan Africa. In 2001, the Meningitis Vaccine Project (MVP), a partnership between the World Health Organization (WHO) and PATH, a Seattle-based NGO, and the Serum Institute of India Pvt Ltd (SIIPL) initiated discussions aimed at establishing a collaborationto develop a Group A meningococcal conjugate vaccine for this unmet medical need. Over the next 8 years the partnership made countless strategic decisions about product characteristics, raw materials, potential target populations, geographic prioritization and affordability of the vaccine to name a few...
October 19, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29037978/expected-immunizations-and-health-protection-for-hajj-and-umrah-2018-an-overview
#8
REVIEW
Jaffar A Al-Tawfiq, Philippe Gautret, Ziad A Memish
BACKGROUND: The annual Hajj and Umrah are one of the largest recurring religious mass gatherings across the globe drawing pilgrims from more than 185 countries. The living circumstances and activities of the pilgrims may create an environment for the occurrence and spread of communicable diseases. Each year, the Health authority of the Kingdom of Saudi Arabia, in coordination with international health authorities, updates health requirements for pilgrims. The Hajj for 2017 took place from August 24 to September 5, 2017...
October 14, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29026659/emergence-and-genomic-diversification-of-a-virulent-serogroup-w-st-2881-cc175-neisseria-meningitidis-clone-in-the-african-meningitis-belt
#9
Araceli Lamelas, Julia Hauser, Jean-Pierre Dangy, Abdul-Wahab M Hamid, Katharina Röltgen, Mohamad R Abdul Sater, Abraham Hodgson, Ali Sie, Thomas Junghanss, Simon R Harris, Julian Parkhill, Stephen D Bentley, Gerd Pluschke
Countries of the African 'meningitis belt' are susceptible to meningococcal meningitis outbreaks. While in the past major epidemics have been primarily caused by serogroup A meningococci, W strains are currently responsible for most of the cases. After an epidemic in Mecca in 2000, W:ST-11 strains have caused many outbreaks worldwide. An unrelated W:ST-2881 clone was described for the first time in 2002, with the first meningitis cases caused by these bacteria reported in 2003. Here we describe results of a comparative whole-genome analysis of 74 W:ST-2881 strains isolated within the framework of two longitudinal colonization and disease studies conducted in Ghana and Burkina Faso...
August 2017: Microbial Genomics
https://www.readbyqxmd.com/read/28992391/four-years-of-case-based-surveillance-of-meningitis-following-the-introduction-of-menafrivac-in-moissala-chad-lessons-learned
#10
Anne-Laure Page, Matthew E Coldiron, Kadidja Gamougam, Mahmaat Ali Acyl, Mbaihol Tamadji, Céline Lastrucci, Northan Hurtado, François-Charles Tehoua, Florence Fermon, Dominique A Caugant, Klaudia Porten
OBJECTIVE: Case-based surveillance of bacterial meningitis in sentinel districts has been recommended after the introduction of the conjugated vaccine against Neisseria meningitidis serogroup A (NmA), MenAfriVac, in the African meningitis belt. Here we report data and lessons learnt from four years of surveillance in the district of Moissala, Chad. METHODS: All suspected cases of meningitis were referred free of charge to the district hospital for lumbar puncture and treatment...
October 9, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28974828/does-dexamethasone-helps-in-meningococcal-sepsis
#11
Ilir Tolaj, Hamdi Ramadani, Murat Mehmeti, Hatixhe Gashi, Arbana Kasumi, Visar Gashi, Haki Jashari
PURPOSE: Prompt recognition and aggressive early treatment are the only effective measures against invasive meningococcal disease (IMD). Anti-inflammatory adjunctive treatment remains controversial and difficult to assess in patients with IMD. The purpose of this study was to evaluate the effect of dexamethasone (DXM) as adjunctive treatment in different clinical forms of IMD, and attempt to answer if DXM should be routinely used in the treatment of IMD. METHODS: In this non-interventional clinical study (NIS), 39 patients with meningococcal septicaemia with or without of meningitis were included, and compared regarding the impact of dexamethasone (DXM), as an adjunctive treatment, on the outcome of IMD...
June 2017: Medical Archives
https://www.readbyqxmd.com/read/28972486/levels-of-neurospecific-markers-in-cerebrospinal-fluid-of-adult-patients-with-bacterial-meningitis
#12
A Sokhan, Y Zots, A Gavrylov, K Iurko, A Solomennik, A Kuznietsova
At present, the great attention is given to the neurospecific markers as their elevated level in the cerebrospinal fluid corresponds to the degree of destruction of relevant CNS cells. Therefore, actual direction of the studies of the pathogenesis and diagnosis of CNS diseases is to determine levels of neurospecific markers in the cerebrospinal fluid (CSF). The purpose of the study was to evaluate the diagnostic and prognostic role of NSE, S-100 protein, GFAP and MBP levels in CSF of patients with acute bacterial meningitis...
September 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28968148/successful-african-introduction-of-a-new-group-a-meningococcal-conjugate-vaccine-future-challenges-and-next-steps
#13
F Marc LaForce, Mamoudou Djingarey, Simonetta Viviani, Marie-Pierre Preziosi
The introduction of a new Group A meningococcal conjugate vaccine, MenAfriVac(R), has been a important public health success. Group A meningococcal meningitis has disappeared in all countries where the new Men A conjugate vaccine has been used at public health scale. However, continued control of Group A disease in sub-Saharan Africa will require that community immunity against Group A meningococci be maintained. Modeling studies have shown that unless herd immunity is maintained Group A meningococcal disease will return...
October 2, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28962886/dissemination-of-the-st-103-clonal-complex-serogroup-c-meningococci-in-salvador-brazil
#14
Soraia Machado Cordeiro, Cristiane Wanderley Cardoso, Lorena Galvão de Araújo, Luis Eduardo Ribeiro, Jailton Azevedo, Rita de Cassia Vilasboas Silva, Mitermayer Galvão Dos Reis, Albert Icksang Ko, Joice Neves Reis
Invasive meningococcal disease (IMD) is a major public health problem worldwide. An epidemic of serogroup C (NmC) IMD occurred in 2010 in the city of Salvador. In this study, we describe the antigenic and genetic characterization of meningococcal isolates collected from meningitis cases in Salvador from 2001 to 2012. Pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST) were performed for the analysis of IMD isolates. A total of 733 cases were identified, and the serogroup was determined for 391 (53...
September 27, 2017: Microbes and Infection
https://www.readbyqxmd.com/read/28933621/neisseria-meningitidis-serogroup-x-st-5799-st-22-complex-in-turkey-a-unique-pediatric-case
#15
Gönül Tanır, Yasemin Ozsurekci, Jay Lucidarme, Sevgi Yaşar Durmuş, Aiswarya Lekshmi, Özlem Akisoglu, Ahmet Emre Aycan, Ray Borrow, Mehmet Ceyhan
Although outbreaks of Neisseria meningitidis serogroup X occured in a couple of African countries, a limited number of serogroup X meningococcal cases were reported in America and Europe as well as Turkey. Additionally, serogroup X is still not represented in current conjugated meningococcal vaccines. Here, we describe the first pediatric case with meningitis caused by Neisseria meningitidis serogroup X ST-5799 (ST-22 complex) that formed a distinct lineage.
September 21, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28912442/the-association-between-respiratory-tract-infection-incidence-and-localised-meningitis-epidemics-an-analysis-of-high-resolution-surveillance-data-from-burkina-faso
#16
Judith E Mueller, Maxime Woringer, Souleymane Porgho, Yoann Madec, Haoua Tall, Nadège Martiny, Brice W Bicaba
Meningococcal meningitis epidemics in the African meningitis belt consist of localised meningitis epidemics (LME) that reach attack proportions of 1% within a few weeks. A meningococcal serogroup A conjugate vaccine was introduced in meningitis belt countries from 2010 on, but LME due to other serogroups continue to occur. The mechanisms underlying LME are poorly understood, but an association with respiratory pathogens has been hypothesised. We analysed national routine surveillance data in high spatial resolution (health centre level) from 13 districts in Burkina Faso, 2004-2014...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28904187/genomic-characterization-of-urethritis-associated-neisseria-meningitidis-shows-that-a-wide-range-of-n-meningitidis-strains-can-cause-urethritis
#17
Kevin C Ma, Magnus Unemo, Samo Jeverica, Robert D Kirkcaldy, Hideyuki Takahashi, Makoto Ohnishi, Yonatan H Grad
Neisseria meningitidis, typically a resident of the oro- or nasopharynx and the causative agent of meningococcal meningitis and meningococcemia, is capable of invading and colonizing the urogenital tract. This can result in urethritis, akin to the syndrome caused by its sister species N. gonorrhoeae, the etiologic agent of gonorrhea. Recently, meningococcal strains associated with outbreaks of urethritis were reported to share genetic characteristics with gonococcus, raising the question of the extent to which these strains contain features that promote adaptation to the genitourinary niche, making them gonococcal-like and distinguishing them from other N...
September 13, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28892991/neisseria-meningitidis-causing-multiple-cerebral-abscesses-in-early-neonatal-period-case-report-and-review-of-literature
#18
Laxman Basani, Roja Aepala
Neisseria meningitidis is a rare cause of meningitis and septicemia in neonates. There are few published case reports of neonatal meningococcal meningitis complicated by subdural empyema, cerebral abscess and hydrocephalus. Few cases of neonatal meningococcal meningitis have been reported in the literature with none of them having the complication of multiple cerebral abscesses in early neonatal period (<seven days of life). We report a case of meningococcal meningitis with multiple cerebral abscesses which presented on fifth day of life and developed hydrocephalus at five weeks of life requiring a Ventriculo Peritoneal (VP) shunt...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28813690/deep-coal-mining-and-meningococcal-meningitis-in-england-and-wales-1931-38-ecological-study-with-implications-for-deep-shaft-mining-activities-worldwide
#19
Matthew R Smallman-Raynor, Andrew D Cliff
The hypothesized role of deep coal mining in the development of community-based outbreaks of meningococcal meningitis has gone largely unexplored. Taking the coalfields of Britain as a historical testbed, techniques of linear and binomial logistic regression were used to assess the association between meningococcal meningitis rates and male occupation rates for coal mining in England and Wales during the national epidemic of 1931-32 and in its aftermath. Adjusting for the epidemiological effects of age, residential density, recent changes in the number of families, housing stock and low social class, the analysis yielded evidence of a significant and positive association between coal mining occupation rates and notified levels of meningitis activity in the epidemic period...
September 2017: Health & Place
https://www.readbyqxmd.com/read/28801740/a-statistical-classifier-to-support-diagnose-meningitis-in-less-developed-areas-of-brazil
#20
Viviane-Maria Lélis, Eduardo Guzmán, María-Victoria Belmonte
This paper describes the development of statistical classifiers to help diagnose meningococcal meningitis, i.e. the most sever, infectious and deadliest type of this disease. The goal is to find a mechanism able to determine whether a patient has this type of meningitis from a set of symptoms that can be directly observed in the earliest stages of this pathology. Currently, in Brazil, a country that is heavily affected by meningitis, all suspected cases require immediate hospitalization and the beginning of a treatment with invasive tests and medicines...
August 11, 2017: Journal of Medical Systems
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