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meningococcal meningitis

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https://www.readbyqxmd.com/read/27921318/meningococcal-vaccination-in-men-who-have-sex-with-men
#1
Christopher W Blackwell
Recent outbreaks of meningitis in men who have sex with men (MSM) in Los Angeles, Chicago, New York City, and other locations across the United States have heightened public health concerns regarding the increasing incidence of meningococcal infections in this vulnerable population. MSM have unique risk factors that result in greater threat from certain infectious diseases, including meningococcal infection. Men who have sex with men who are infected with HIV are at even higher risk. This article explores the increased risks among MSM in contracting and communicating meningococcal infection, use of vaccination as primary prevention, and outreach strategies that may help address this issue and lessen the disease burden associated with meningococcal infection in these sexual minorities...
December 5, 2016: Public Health Nursing
https://www.readbyqxmd.com/read/27921012/expression-of-the-gene-for-autotransporter-autb-of-neisseria-meningitidis-affects-biofilm-formation-and-epithelial-transmigration
#2
Jesús Arenas, Fernanda L Paganelli, Patricia Rodríguez-Castaño, Sara Cano-Crespo, Arie van der Ende, Jos P M van Putten, Jan Tommassen
Neisseria meningitidis is a Gram-negative bacterium that resides as a commensal in the upper respiratory tract of humans, but occasionally, it invades the host and causes sepsis and/or meningitis. The bacterium can produce eight autotransporters, seven of which have been studied to some detail. The remaining one, AutB, has not been characterized yet. Here, we show that the autB gene is broadly distributed among pathogenic Neisseria spp. The gene is intact in most meningococcal strains. However, its expression is prone to phase variation due to slipped-strand mispairing at AAGC repeats located within the DNA encoding the signal sequence and is switched off in the vast majority of these strains...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27909580/burden-of-neisseria-meningitidis-infections-in-china-a-systematic-review-and-meta-analysis
#3
Yaowen Zhang, Dong Wei, Xinzhen Guo, Mai Han, Lichao Yuan, Moe H Kyaw
BACKGROUND: Neisseria meningitidis is a leading cause of bacterial meningitis and septicemia in children and young adults worldwide. The disease burden associated with N. meningitidis infections has not been systematically assessed in China. Therefore, we undertook this study to determine the burden of meningococcal disease in China. METHOD: We performed a systematic review and meta-analysis of articles on N. meningitidis incidence, carriage, seroprevalence and mortality rates in China by searching the Chinese BioMedical Database (CBM), China National Knowledge Infrastructure (CNKI), Wanfang database and PubMed for publications from January 2005 to Aug 2015...
December 2016: Journal of Global Health
https://www.readbyqxmd.com/read/27904879/the-establishment-and-diversification-of-epidemic-associated-serogroup-w-meningococcus-in-the-african-meningitis-belt-1994-to-2012
#4
Adam C Retchless, Fang Hu, Abdoul-Salam Ouédraogo, Seydou Diarra, Kristen Knipe, Mili Sheth, Lori A Rowe, Lassana Sangaré, Absetou Ky Ba, Soumeya Ouangraoua, Dhwani Batra, Ryan T Novak, Rasmata Ouédraogo Traoré, Xin Wang
Epidemics of invasive meningococcal disease (IMD) caused by meningococcal serogroup A have been eliminated from the sub-Saharan African so-called "meningitis belt" by the meningococcal A conjugate vaccine (MACV), and yet, other serogroups continue to cause epidemics. Neisseria meningitidis serogroup W remains a major cause of disease in the region, with most isolates belonging to clonal complex 11 (CC11). Here, the genetic variation within and between epidemic-associated strains was assessed by sequencing the genomes of 92 N...
November 2016: MSphere
https://www.readbyqxmd.com/read/27902653/meningococcal-disease-in-children-in-argentina-a-three-year-active-sentinel-hospital-surveillance-study
#5
Ángela Gentile, Julia Bakir, María Rosa Agosti, Gabriela Ensinck, Hector Abate, Andrea Gajo Gane, Alejandro Santillán Iturres, Adriana Efron, Mabel Regueira, Ricardo Rüttimann
BACKGROUND: Meningococcal disease (MD) is a medical emergency and a serious public health problem. As new meningococcal vaccines become available, MD surveillance is crucial to provide baseline epidemiologic data before implementing preventive measures. We estimated MD incidence and epidemiology in Argentina using hospital-based surveillance. METHODS: 3-year prospective active surveillance in patients ≤15 years of age conducted at 6 pediatric hospital sentinel units (March 2012-February 2015)...
November 28, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27901251/meningococcal-meningitis-clinical-and-laboratorial-characteristics-fatality-rate-and-variables-associated-with-in-hospital-mortality
#6
Vanessa L Strelow, Érique José F Peixoto de Miranda, Karin R Kolbe, Juliana V Souza Framil, Augusto Penalva de Oliveira, José E Vidal
Meningococcal meningitis is a public health problem. The aim of this study was to describe the clinical characteristics of patients with meningococcal meningitis, and to identify associated factors with mortality. This was a retrospective study, between 2006 and 2011, at a referral center in São Paulo, Brazil. Logistic regression analysis was used to identify factors associated with mortality. We included 316 patients. The median age was 16 years (IQR: 7-27) and 60% were male. The clinical triad: fever, headache and neck stiffness was observed in 89% of the patients...
November 2016: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/27884478/vaccine-provision-delivering-sustained-widespread-use
#7
Scott Preiss, Nathalie Garçon, Anthony L Cunningham, Richard Strugnell, Leonard R Friedland
The administration of a vaccine to a recipient is the final step in a development and production process that may have begun several decades earlier. Here we describe the scale and complexity of the processes that brings a candidate vaccine through clinical development to the recipient. These challenges include ensuring vaccine quality (between 100 and 500 different Quality Control tests are performed during production to continually assess safety, potency and purity); making decisions about optimal vaccine presentation (pre-filled syringes versus multi-dose vials) that affect capacity and supply; and the importance of maintaining the vaccine cold chain (most vaccines have stringent storage temperature requirements necessary to maintain activity and potency)...
November 21, 2016: Vaccine
https://www.readbyqxmd.com/read/27876190/-bilateral-abducens-nerve-palsy-as-the-initial-clinical-manifestation-of-meningococcal-meningitis
#8
Ana Camacho Salas, Pablo Rojo Conejo, Noemí Núñez Enamorado, Rogelio Simón de Las Heras
No abstract text is available yet for this article.
November 18, 2016: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/27855873/household-transmission-of-neisseria-meningitidis-in-the-african-meningitis-belt-a-longitudinal-cohort-study
#9
(no author information available yet)
BACKGROUND: Information on transmission of meningococcal infection in the African meningitis belt is scarce. We aimed to describe transmission patterns of Neisseria meningitidis (meningococcus) in households in the African meningitis belt. METHODS: Cross-sectional carriage surveys were done in seven African meningitis belt countries (Chad, Ethiopia, Ghana, Mali, Niger, Nigeria, and Senegal) between Aug 1, 2010, and Oct 15, 2012. Meningococcal carriers identified in these surveys and all available people in their households were recruited into this longitudinal cohort study...
December 2016: Lancet Global Health
https://www.readbyqxmd.com/read/27832151/nationwide-trends-in-bacterial-meningitis-before-the-introduction-of-13-valent-pneumococcal-conjugate-vaccine-burkina-faso-2011-2013
#10
Dinanibè Kambiré, Heidi M Soeters, Rasmata Ouédraogo-Traoré, Isaïe Medah, Lassana Sangare, Issaka Yaméogo, Guetawendé Sawadogo, Abdoul-Salam Ouédraogo, Soumeya Hema-Ouangraoua, Lesley McGee, Velusamy Srinivasan, Flavien Aké, Malika Congo-Ouédraogo, Soufian Sanou, Absatou Ky Ba, Ryan T Novak, Chris Van Beneden
BACKGROUND: Following introduction of Haemophilus influenzae type b vaccine in 2006 and serogroup A meningococcal conjugate vaccine in 2010, Streptococcus pneumoniae (Sp) became the leading cause of bacterial meningitis in Burkina Faso. We describe bacterial meningitis epidemiology, focusing on pneumococcal meningitis, before 13-valent pneumococcal conjugate vaccine (PCV13) introduction in the pediatric routine immunization program in October 2013. METHODS: Nationwide population-based meningitis surveillance collects case-level demographic and clinical information and cerebrospinal fluid (CSF) laboratory results...
2016: PloS One
https://www.readbyqxmd.com/read/27820969/the-global-meningococcal-initiative-global-epidemiology-the-impact-of-vaccines-on-meningococcal-disease-and-the-importance-of-herd-protection
#11
Ray Borrow, Pedro Alarcón, Josefina Carlos, Dominique A Caugant, Hannah Christensen, Roberto Debbag, Philippe De Wals, Gabriela Echániz-Aviles, Jamie Findlow, Chris Head, Daphne Holt, Hajime Kamiya, Samir K Saha, Sergey Sidorenko, Muhamed-Kheir Taha, Caroline Trotter, Julio A Vázquez Moreno, Anne von Gottberg, Marco A P Sáfadi
The 2015 Global Meningococcal Initiative (GMI) meeting discussed the global importance of meningococcal disease (MD) and its continually changing epidemiology. Areas covered: Although recent vaccination programs have been successful in reducing incidence in many countries (e.g. Neisseria meningitidis serogroup [Men]C in Brazil, MenA in the African meningitis belt), new clones have emerged, causing outbreaks (e.g. MenW in South America, MenC in Nigeria and Niger). The importance of herd protection was highlighted, emphasizing the need for high vaccination uptake among those with the highest carriage rates, as was the need for boosters to maintain individual and herd protection following decline of immune response after primary immunization...
November 22, 2016: Expert Review of Vaccines
https://www.readbyqxmd.com/read/27812059/detection-of-meningococcal-meningitis-in-cerebrospinal-fluid-of-patients-with-neurological-disorders-in-government-hospitals-of-karachi
#12
Aneela Taj, Nusrat Jamil
OBJECTIVE: To investigate the microbiological yield from the apparently transparent cerebrospinal fluid samples of in-patients with suspected neurological disorders. METHODS: Samples of CSF were collected from Neurology and Neurosurgery Wards of the Jinnah Postgraduate Medical Centre and the Civil Hospital, Karachi, from December 2007 to March 2012, and comprised cerebrospinal fluid samples collected from neurologically compromised patients through lumbar puncture...
November 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27753774/neonatal-meningococcal-meningitis-in-france-from-2001-to-2013
#13
Ali Bilal, Muhamed-Kheir Taha, Laurence Caeymaex, Robert Cohen, Corinne Levy, Xavier Durrmeyer
Among 831 cases of neonatal bacterial meningitis occurring from 2001 to 2013, Neisseria meningitidis was the third most frequent bacterial species found. All cases occurred only in term neonates and were mainly late onset. Serogroup B accounted for 78% of cases. At diagnosis, 27% of cases had at least one sign of disease severity. All strains were susceptible to cefotaxime, but 12% showed intermediate susceptibility to penicillin G and to aminopenicillin.
November 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27703989/a-case-of-meningococcal-pyomyositis-in-an-otherwise-healthy-adult
#14
Monique T Barakat, Kiran Gajurel, Katrina Fischer, Kathryn Stevens, Errol Ozdalga, José G Montoya
The clinical spectrum of Neisseria meningitidis can range from nasopharyngeal colonization to life-threatening invasive diseases such as meningitis. However, its etiologic role in invasive pyomyositis (PM) has never been reported before in the English language. In this study, we report the first case of PM in the English language and the second case in the literature caused by N meningitidis.
September 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27681925/correia-repeat-enclosed-elements-and-non-coding-rnas-in-the-neisseria-species
#15
Sabrina B Roberts, Russell Spencer-Smith, Mahwish Shah, Jean-Christophe Nebel, Richard T Cook, Lori A S Snyder
Neisseria gonorrhoeae is capable of causing gonorrhoea and more complex diseases in the human host. Neisseria meningitidis is a closely related pathogen that shares many of the same genomic features and virulence factors, but causes the life threatening diseases meningococcal meningitis and septicaemia. The importance of non-coding RNAs in gene regulation has become increasingly evident having been demonstrated to be involved in regulons responsible for iron acquisition, antigenic variation, and virulence. Neisseria spp...
August 25, 2016: Microorganisms
https://www.readbyqxmd.com/read/27668905/atypical-clinical-presentation-of-meningococcal-meningitis-a-case-report
#16
Ilaria Izzo, Paola Pileri, Maria Merello, Paolo Gnesin, Enrico Cogi, Carlo Aggiusti, Laura Giacomelli, Stefano Ettori, Paolo Colombini, Andrea Collidá
A young woman was examined in the Emergency Department for fever, pharyngitis and widespread petechial rash. Physical examination, including neurological evaluation, did not show any other abnormalities. Chest X-ray was negative. Blood exams showed leukocytosis and CPR 20 mg/dL (nv<0.5 mg/dL). On the basis of these results and petechial rash evidence, lumbar puncture was performed. CSF was opalescent; physico-chemical examination showed: total proteins 2.8 (nv 0.15-0.45), glucose 5 (nv 59-80), WBC 7600/μL (nv 0-4/ μL)...
September 1, 2016: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/27651089/immune-responses-of-a-meningococcal-a-w-outer-membrane-vesicle-omv-vaccine-with-and-without-aluminium-hydroxide-adjuvant-in-two-different-mouse-strains
#17
Gro Tunheim, Marianne Arnemo, Lisbeth M Naess, Gunnstein Norheim, Luis Garcia, Daniel Cardoso, Aleida Mandiarote, Domingo Gonzalez, Kalpana Sinnadurai, Åse-Karine Fjeldheim, Karin Bolstad, Einar Rosenqvist
Meningococci (Neisseria meningiditis) of serogroups A and W have caused large epidemics of meningitis in sub-Saharan Africa for decades, and affordable and multivalent vaccines, effective in all age groups, are needed. A bivalent serogroup A and W (A + W) meningococcal vaccine candidate consisting of deoxycholate-extracted outer membrane vesicles (OMV) from representative African disease isolates was previously found to be highly immunogenic in outbred mice when formulated with the adjuvant aluminium hydroxide (AH)...
November 2016: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/27649262/whole-genome-characterization-of-epidemic-neisseria-meningitidis-serogroup-c-and-resurgence-of-serogroup-w-niger-2015
#18
Cecilia B Kretz, Adam C Retchless, Fati Sidikou, Bassira Issaka, Sani Ousmane, Stephanie Schwartz, Ashley H Tate, Assimawè Pana, Berthe-Marie Njanpop-Lafourcade, Innocent Nzeyimana, Ricardo Obama Nse, Ala-Eddine Deghmane, Eva Hong, Ola Brønstad Brynildsrud, Ryan T Novak, Sarah A Meyer, Odile Ouwe Missi Oukem-Boyer, Olivier Ronveaux, Dominique A Caugant, Muhamed-Kheir Taha, Xin Wang
In 2015, Niger reported the largest epidemic of Neisseria meningitidis serogroup C (NmC) meningitis in sub-Saharan Africa. The NmC epidemic coincided with serogroup W (NmW) cases during the epidemic season, resulting in a total of 9,367 meningococcal cases through June 2015. To clarify the phylogenetic association, genetic evolution, and antibiotic determinants of the meningococcal strains in Niger, we sequenced the genomes of 102 isolates from this epidemic, comprising 81 NmC and 21 NmW isolates. The genomes of 82 isolates were completed, and all 102 were included in the analysis...
October 2016: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/27631124/neisseria-meningitidis-presenting-as-acute-abdomen-and-recurrent-reactive-pericarditis
#19
Karolina Akinosoglou, Angelos Alexopoulos, Nikolaos Koutsogiannis, Charalampos Gogos, Aleksandra Lekkou
Meningococcal meningitis is a well established potential fatal infection characterized by fever, headache, petechial rash, and vomiting in the majority of cases. However, protean manifestations including abdominal pain, sore throat, diarrhea and cough, even though rare, should not be overlooked. Similarly, although disseminated infection could potentially involve various organ-targets, secondary immune related complications including joints or pericardium should be dealt with caution, since they remain unresponsive to appropriate antibiotic regimens...
September 12, 2016: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27604766/the-dual-role-of-lipids-of-the-lipoproteins-in-trumenba-a-self-adjuvanting-vaccine-against-meningococcal-meningitis-b-disease
#20
Yin Luo, Olga V Friese, Herbert A Runnels, Lakshmi Khandke, Gary Zlotnick, Ann Aulabaugh, Thomas Gore, Eugene Vidunas, Stephen W Raso, Elena Novikova, Emilia Byrne, Michael Schlittler, Donald Stano, Robert L Dufield, Sandeep Kumar, Annaliesa S Anderson, Kathrin U Jansen, Jason C Rouse
Trumenba (bivalent rLP2086) is a vaccine licensed for the prevention of meningococcal meningitis disease caused by Neisseria meningitidis serogroup B (NmB) in individuals 10-25 years of age in the USA. The vaccine is composed of two factor H binding protein (fHbp) variants that were recombinantly expressed in Escherichia coli as native lipoproteins: rLP2086-A05 and rLP2086-B01. The vaccine was shown to induce potent bactericidal antibodies against a broad range of NmB isolates expressing fHbp that were different in sequence from the fHbp vaccine antigens...
September 7, 2016: AAPS Journal
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