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https://www.readbyqxmd.com/read/29676176/effect-of-mecp2-on-tgf-%C3%AE-1-induced-extracellular-matrix-production-in-nasal-polyp-derived-fibroblasts
#1
Jae-Min Shin, Ji-Young Um, Seoung-Ae Lee, Il-Ho Park, Soo-Hyung Lee, Heung-Man Lee
Purpose Methyl-CpG-binding protein 2 (MeCP2), known as a transcriptional regulator, has been suggested to play an important role in myofibroblast differentiation in the lung. The purpose of this study was to investigate the role of MeCP2 in transforming growth factor (TGF)- β1-induced myofibroblast differentiation and extracellular matrix (ECM) production in nasal polyp-derived fibroblasts (NPDFs). Methods To identify the expression of MeCP2 in nasal polyp tissues, immunohistochemistry staining and Western blot were performed...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29675857/efficacy-and-safety-of-cold-versus-hot-snare-polypectomy-for-resecting-small-colorectal-polyps-systematic-review-and-meta-analysis
#2
REVIEW
Satoshi Shinozaki, Yasutoshi Kobayashi, Yoshikazu Hayashi, Hirotsugu Sakamoto, Alan Kawarai Lefor, Hironori Yamamoto
BACKGROUND AND AIM: The safety and effectiveness of cold snare polypectomy (CSP) compared with hot snare polypectomy (HSP) has been reported. The aim of this study is to perform a meta-analysis of the efficacy and safety of HSP and CSP. METHODS: Randomized-controlled trials were reviewed to compare HSP with CSP for resecting small colorectal polyps. The outcomes reviewed include complete resection rate, polyp retrieval, delayed bleeding, perforation and procedure time...
April 19, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29671617/oxazole-and-thiazole-analogs-of-sulindac-for-cancer-prevention
#3
Bini Mathew, Judith V Hobrath, Michele C Connelly, R Kiplin Guy, Robert C Reynolds
AIM: Experimental and epidemiological studies and clinical trials suggest that nonsteroidal anti-inflammatory drugs possess antitumor potential. Sulindac, a widely used nonsteroidal anti-inflammatory drug, can prevent adenomatous colorectal polyps and colon cancer, especially in patients with familial adenomatous polyposis. Sulindac sulfide amide (SSA) is an amide-linked sulindac sulfide analog that showed in vivo antitumor activity in a human colon tumor xenograft model. Results/methodology: A new analog series with heterocyclic rings such as oxazole or thiazole at the C-2 position of sulindac was prepared and screened against prostate, colon and breast cancer cell lines to probe the effect of these novel substitutions on the activity of sulindac analogs...
April 19, 2018: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/29668543/multiple-epstein-barr-virus-associated-smooth-muscle-sarcomas-of-the-gut-in-a-child-treated-for-acute-lymphoblastic-leukemia
#4
Cécile Boulanger, Maëlle de Ville de Goyet, Catherine de Magnée, Sophie Dupont, Christine Galant, An Van Damme, Bénédicte Brichard
A 7-year-old boy with a history of low-risk acute lymphoblastic leukemia developed multiple intussusceptions shortly after the end of maintenance therapy. Explorative laparotomy showed >10 polyps in the small intestine. Histologic examination revealed intestinal smooth muscle sarcomas associated with Epstein-Barr virus. The patient recovered well after partial cuneiform resection of the largest polyps and treatment with sirolimus. This case report indicates that these tumors may arise even after moderate transient immunosuppression and that association with acute lymphoblastic leukemia is possible although rarely described...
April 17, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29665631/primary-colonic-follicular-lymphoma-presenting-as-four-diminutive-sessile-polyps-found-incidentally-during-colonoscopy
#5
Sun Jin, Hyun Seok Lee, Ji Yun Jeong, Young Wook Jo
Follicular lymphomas, which typically arise in the lymph nodes with spleen, liver, and bone marrow involvement, have generally low occurrence rates in Asian countries as compared with Western countries. Follicular lymphomas of the gastrointestinal tract are rare, and primary colonic follicular lymphomas are particularly rare compared with others found in the small intestine and duodenum. Colonoscopic imaging of colonic lymphomas, including follicular lymphoma, may reveal mucosal ulcerations, erosions, indurations, polypoid mass-like lesions, and diffuse mucosal nodularity...
April 18, 2018: Clinical Endoscopy
https://www.readbyqxmd.com/read/29665615/correction-development-and-validation-of-the-simple-endoscopic-classification-of-diminutive-and-small-colorectal-polyps
#6
Marietta Iacucci, Cristina Trovato, Marco Daperno, Oluseyi Akinola, David Greenwald, Seth A Gross, Arthur Hoffman, Jeffrey Lee, Brendan C Lethebe, Mark Lowerison, Jennifer Nayor, Helmut Neumann, Timo Rath, Silvia Sanduleanu, Prateek Sharma, Ralf Kiesslich, Subrata Ghosh, John R Saltzman
No abstract text is available yet for this article.
April 17, 2018: Endoscopy
https://www.readbyqxmd.com/read/29662295/should-hot-biopsy-forceps-be-abandoned-for-polypectomy-of-diminutive-colorectal-polyps
#7
Vasileios Panteris, Antonios Vezakis, J K Triantafillidis
Standardized approach to polypectomy of diminutive colorectal polyps (DCPs) is lacking since cold biopsy forceps have been associated with high levels of recurrence, hot biopsy forceps are considered inadequate and risky and cold snaring is currently under investigation for its efficacy and safety. This has led to confusion and a gap in clinical practice. This article discusses the usefulness and contemporary practical applicability of hot biopsy forceps and provides well-intentioned criticism of the new European guidelines for the treatment of DCPs...
April 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29661177/loss-of-zg16-is-associated-with-molecular-and-clinicopathological-phenotypes-of-colorectal-cancer
#8
Hui Meng, Wencai Li, Lisa A Boardman, Liang Wang
BACKGROUND: Zymogen granule protein 16 (ZG16) is one of the most significantly down-regulated genes in colorectal cancer (CRC) tissues. This study aimed to further evaluate its expression changes and investigate its association with molecular and clinicopathological characteristics of CRC. METHODS: We applied quantitative RT-PCR to determine expression difference between tumor and matched normal tissues from 23 CRC patients. To further validate the down-regulation in tumor tissues, we performed immunohistochemistry (IHC) analysis in 40 paraffin-embedded normal-tumor pairs and 22 colon tissues with a variety of diseases...
April 16, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29658649/challenges-associated-with-the-pathological-diagnosis-of-colorectal-tumors-less-than-10-mm-in-size
#9
REVIEW
Shin Ichihara, Toshio Uraoka, Shiro Oka
Various techniques including cold snare polypectomy and endoscopic mucosal resection are used for the removal of small colorectal polyps. Specimens of resected polyps are prepared in pathology laboratories and analyzed to make a pathological diagnosis. However, reports on how different resection methods influence the pathological diagnosis are limited. This article discusses the problems associated with the failure of polyp retrieval and fragmentation of small specimens during collection and the effects of certain parameters on the pathological diagnosis, particularly with regard to surgical margins...
April 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29626250/effect-of-voice-therapy-on-vocal-fold-polyp-treatment
#10
Mustafa Sahin, Sercan Gode, Murat Dogan, Tayfun Kirazli, Fatih Ogut
PURPOSE: To investigate the role of voice therapy (VT) and factors that may affect the response to VT in the treatment of vocal fold polyps, especially as a complement to phonosurgery. METHODS: Retrospective review of patients with vocal fold polyp undergoing surgery and/or VT in a tertiary medical center. The demographic data, phoniatric history, videolaryngostroboscopic findings, polyp characteristics, VHI-10 and GRB scores, and voice analysis data were recorded before and after the treatment...
April 6, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29622347/optical-imaging-with-a-high-resolution-microendoscope-to-identify-sinonasal-pathology
#11
Sarah M Kidwai, Arjun K Parasher, Victor J Schorn, Elizabeth G Demicco, Rebecca Richards-Kortum, Alfred Marc Iloreta, Satish Govindaraj, Brett A Miles
OBJECTIVES: High-resolution microendoscopy (HRME) is an optical imaging modality that allows real time imaging of epithelial tissue and structural changes within. We hypothesize that HRME, using proflavine, a contrast agent that preferentially stains cell nuclei and allows detection of cellular morphologic changes, can distinguish sinonasal pathology from uninvolved mucosa, potentially enabling real-time surgical margin differentiation. STUDY DESIGN: Ex vivo imaging of histopathologically confirmed samples of sinonasal pathology and uninvolved, normal sinus epithelium...
March 20, 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29616100/diagnosis-and-treatment-of-submucous-myoma-of-the-uterus-with-interventional-ultrasound
#12
Bo Liang, Yang-Gui Xie, Xiao-Ping Xu, Chun-Hong Hu
The value of interventional ultrasound in the diagnosis and treatment of submucous myoma of the uterus was assessed to study the ultrasonographic features of modified sonohysterography for submucous polyp of uterus. A total of 25 patients diagnosed preliminarily as submucous myoma of the uterus via conventional ultrasound examination from June 2014 to December 2016 were enrolled in the study. The diagnosis was made via the comprehensive analysis of ultrasound-guided modified SHG, followed by ultrasound-guided needle biopsy and sclerotherapy of tumor...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29574427/septic-presentation-of-a-giant-fibroepithelial-polyp-of-the-vulva
#13
Arzoo Amin, Zohra Amin, Abdul Rahman Al Farsi
Fibroepithelial stromal polyps are mesenchymal lesions occurring typically in reproductive age women with a predilection for the vulvo-vaginal region. Malignancy may mimic this polyp in morphology, rendering further investigations including detailed histopathology mandatory. Histologically its characteristic features are stellate and multinucleate stromal cells identified near the epithelial-stromal interface. This case report discusses incidental finding of largest fibroepithelial polyp presented in a 31-year-old nulliparous woman...
March 23, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29572575/metastatic-colonic-and-gastric-polyps-from-breast-cancer-resembling-hyperplastic-polyps
#14
Yoshiya Horimoto, Tetsuro Hirashima, Atsushi Arakawa, Hiroyoshi Miura, Mitsue Saito
Breast cancer metastasis to the gastrointestinal tract is relatively rare and is generally found when patients complain of symptoms such as gastrointestinal obstruction. Herein, we report a case with metastatic colonic and gastric lesions from breast cancer, with the formation of mucosal polyps which resembled typical hyperplastic polyps.A 47-year-old woman underwent curable surgery for breast cancer and received standard systemic treatments. Her primary tumor was composed of a mix of invasive lobular and ductal carcinomas...
March 23, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29571175/development-and-validation-of-the-simple-endoscopic-classification-of-diminutive-and-small-colorectal-polyps
#15
Marietta Iacucci, Cristina Trovato, Marco Daperno, Oluseyi Akinola, David Greenwald, Seth A Gross, Arthur Hoffman, Jeffrey Lee, Brendan C Lethebe, Mark Lowerison, Jennifer Nayor, Helmut Neumann, Timo Rath, Silvia Sanduleanu, Prateek Sharma, Ralf Kiesslich, Subrata Ghosh, John R Saltzman
BACKGROUND: Prediction of histology of small polyps facilitates colonoscopic treatment. The aims of this study were: 1) to develop a simplified polyp classification, 2) to evaluate its performance in predicting polyp histology, and 3) to evaluate the reproducibility of the classification by trainees using multiplatform endoscopic systems. METHODS: In phase 1, a new simplified endoscopic classification for polyps - Simplified Identification Method for Polyp Labeling during Endoscopy (SIMPLE) - was created, using the new I-SCAN OE system (Pentax, Tokyo, Japan), by eight international experts...
March 23, 2018: Endoscopy
https://www.readbyqxmd.com/read/29568523/blood-microvasculature-and-lymphatic-densities-in-endometrial-polyps-and-adjacent-and-distant-endometrium
#16
Njume Peter Nijkang, Lyndal Anderson, Robert Markham, Ian Stewart Fraser, Frank Manconi
Objective: Endometrial polyps are localised growths of endometrial tissue containing glands, stroma and blood vessels, covered with epithelium. The reported prevalence of endometrial polyps is dependent upon the population being studied and the uterine imaging technique utilised. The light microscopy literature provides very little information regarding their microvasculature and lymphatic systems; however, a plethora of ultrasound data demonstrating single central arteries in most medium- or large-sized endometrial polyps are well documented...
2018: SAGE Open Medicine
https://www.readbyqxmd.com/read/29557412/factors-associated-with-possibly-inappropriate-histological-evaluation-of-excised-specimens-in-cold-snare-polypectomy-for-small-colorectal-polyps
#17
Yuichi Shimodate, Junya Itakura, Motowo Mizuno, Rio Takezawa, Mami Kobayashi, Tatsuhiro Yamazaki, Akira Doi, Naoyuki Nishimura, Hirokazu Mouri, Kazuhiro Matsueda, Hiroshi Yamamoto
BACKGROUND AND AIMS: Small colorectal polyps may be removed with cold snare polypectomy (CSP). Some of these polyps may contain unexpectedly advanced neoplasia. Thus, it is important to establish criteria for excision that will ensure that the CSP specimens are adequate for accurate histological assessment. We retrospectively investigated depth of excised small polyps and their vertical margins in patients who underwent CSP. METHOD: CSP-excised specimens of 376 small colorectal polyps were examined...
March 2018: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/29556334/potential-red-flag-identification-of-colorectal-adenomas-with-wide-field-fluorescence-molecular-endoscopy
#18
Elmire Hartmans, Jolien J J Tjalma, Matthijs D Linssen, Pilar Beatriz Garcia Allende, Marjory Koller, Annelies Jorritsma-Smit, Mariana E Silva de Oliveira Nery, Sjoerd G Elias, Arend Karrenbeld, Elisabeth G E de Vries, Jan H Kleibeuker, Gooitzen M van Dam, Dominic J Robinson, Vasilis Ntziachristos, Wouter B Nagengast
Adenoma miss rates in colonoscopy are unacceptably high, especially for sessile serrated adenomas / polyps (SSA/Ps) and in high-risk populations, such as patients with Lynch syndrome. Detection rates may be improved by fluorescence molecular endoscopy (FME), which allows morphological visualization of lesions with high-definition white-light imaging as well as fluorescence-guided identification of lesions with a specific molecular marker. In a clinical proof-of-principal study, we investigated FME for colorectal adenoma detection, using a fluorescently labelled antibody (bevacizumab-800CW) against vascular endothelial growth factor A (VEGFA), which is highly upregulated in colorectal adenomas...
2018: Theranostics
https://www.readbyqxmd.com/read/29554795/laparoscopic-resection-of-a-jejunal-inflammatory-fibroid-polyp-that-caused-occult-gastrointestinal-bleeding-diagnosed-via-capsule-endoscopy-and-double-balloon-enteroscopy-a-case-report
#19
Chizu Kameda, Hideaki Miwa, Ryohei Kawabata, Daiki Marukawa, Masahiro Murakami, Shingo Noura, Junzo Shimizu, Junichi Hasegawa
An inflammatory fibroid polyp (IFP) is a mesenchymal tumor of the gastrointestinal tract. IFPs in the small intestine are the most frequently detected with symptoms, such as abdominal pain and tarry stool due to intussusception. Accordingly, few studies have reported jejunal IFP as a cause of occult gastrointestinal bleeding (OGIB) diagnosed via both of capsule endoscopy (CE) and double-balloon enteroscopy (DBE). A 68-year-old woman presented with a progression of anemia and a positive fecal occult blood test result...
March 20, 2018: Clinical Endoscopy
https://www.readbyqxmd.com/read/29545870/diagnostic-value-of-omom-capsule-endoscopy-for-small-bowel-diseases-in-adults
#20
Lili Zhang, Junsong Shen, Linchun Guo, Fenggan Cheng, Qi Fan, Keqian Ni, Shujing Xia, Detong Zhou
The present study aimed to determine the diagnostic yield of OMOM capsule endoscopy for small bowel diseases in adults. A total of 89 patients, including 45 cases of obscure abdominal pain, 22 of chronic diarrhea, 18 of obscure gastrointestinal bleeding and 4 of obscure anemia were enrolled in the present study. The transit time of the endoscopy capsule in the digestive tract was recorded and the testing results were analyzed. All detections were completed except for four capsule retentions and the completion rate was 95...
April 2018: Experimental and Therapeutic Medicine
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