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https://www.readbyqxmd.com/read/28816375/adenocarcinoma-of-the-colon-presenting-as-a-submucosal-tumor
#1
Hourin Cho, Shigeki Sekine, Masau Sekiguchi
A 64-year-old woman underwent colonoscopy for abdominal discomfort and a protruded lesion measuring approximately 10 mm was detected in the descending colon. The tumor was entirely covered by normal-appearing mucosa and was regarded as a submucosal tumor (SMT). A small adenomatous polyp was present beside the SMT (Figure 1). For precise histological assessment of the SMT and therapeutic purpose of the coexisted polyp, we performed complete resection of the lesions by endoscopic submucosal dissection. This article is protected by copyright...
August 17, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28771607/il-25-induced-activation-of-nasal-fibroblast-and-its-association-with-the-remodeling-of-chronic-rhinosinusitis-with-nasal-polyposis
#2
Soo-Kyoung Park, Yong-De Jin, Yeong-Kyu Park, Sun-Hee Yeon, Jun Xu, Rui-Ning Han, Ki-Sang Rha, Yong-Min Kim
BACKGROUND AND OBJECTIVE: Interleukin (IL)-25 has been shown to play an important role in the pathogenesis of chronic rhinosinusitis with nasal polyps. Nasal polyps are associated with chronic inflammation of the mucous membranes in the paranasal sinuses and are involved in extracellular matrix (ECM) accumulation. The aim of this study is to evaluate the effects of IL-25 on myofibroblast differentiation, ECM production and the expression of matrix metalloproteinases in nasal polyp derived fibroblasts (NPDFs) and to determine the molecular mechanism underlying these processes...
2017: PloS One
https://www.readbyqxmd.com/read/28762356/antrochoanal-polyp-arising-from-benign-pseudocyst-of-maxillary-antrum
#3
Neha Keshri, Avi Bansal, Gourav Popli, Arvind Venkatesh, Siddhartha Goel
Antrochoanal polyps (ACPs) are benign lesions that arise from the mucosa of the maxillary antrum, grow into the maxillary sinus, and reach the choana with nasal obstruction being their main symptom. Most of these lesions are small and clinically silent and found as incidental finding, but large cysts which occupy the entire antrum have also been reported in literature. Nasal endoscopy and computer tomography (CT) are the golden standard in the diagnosis of ACPs, and enucleation by Caldwell-Luc approach is the recommended treatment for larger antral cysts...
July 2017: Journal of the Indian Society of Pedodontics and Preventive Dentistry
https://www.readbyqxmd.com/read/28758041/an-unusual-cause-of-intestinal-obstruction-in-a-young-adult-patient-inflammatory-fibroid-polyp
#4
Meryem Rais, Hafsa Chahdi, Mohammed Elfahssi, Abderrahmane Albouzidi, Mohamed Oukabli
Inflammatory fibroid polyps are uncommon benign lesions that originate in the submucosa of the gastrointestinal tract. The stomach and the ileum are the most commonly affected sites. Although inflammatory fibroid polyp is one of the rare conditions leading to intestinal obstruction in adults, it should be considered as a possible diagnosis in obstructive tumors of the small bowel causing intussusceptions. We present one case of inflammatory fibroid polyp as a rare cause of intussusception in a young adult patient...
2017: Case Reports in Surgery
https://www.readbyqxmd.com/read/28740967/incidental-gastrointestinal-stromal-tumor-at-a-gastroscopic-polypectomy-specimen-a-case-report-and-review-of-literature
#5
Dursun Özgür Karakaş, Özgür Dandin, Ahmet Ziya Balta, Yavuz Özdemir, İsmail Yılmaz, İlker Sücüllü
Although gastrointestinal stromal tumors (GISTs) comprise less than 1% of all gastrointestinal (GI) tract tumors, they are the most common mesenchymal tumors of the GI tract. Gastrointestinal stromal tumors can occur anywhere along the GI tract, but the stomach and small intestine are the most frequently involved sites. Gastrointestinal stromal tumors are frequently asymptomatic, and one-third of all cases are found incidentally. Endoscopy, endoscopic ultrasonography, and computed tomography are useful tools in the diagnosis...
2017: Turk J Surg
https://www.readbyqxmd.com/read/28730368/safety-of-cold-polypectomy-for-small-colorectal-neoplastic-lesions-a-prospective-cohort-study-in-japan
#6
Yuichi Shimodate, Motowo Mizuno, Rio Takezawa, Mami Kobayashi, Tatsuhiro Yamazaki, Akira Doi, Naoyuki Nishimura, Hirokazu Mouri, Kazuhiro Matsueda, Hiroshi Yamamoto
BACKGROUND: Cold polypectomy has been widely accepted for removal of small colorectal polyps. However, no large-scale prospective study exists as for its safety in Japan. We investigated this issue in this single-center, prospective cohort study in a total of 1198 colorectal polyps resected with cold polypectomy. PATIENTS AND METHODS: Four hundred and seventy-four patients who underwent cold polypectomy for colorectal neoplastic lesions less than 10-mm diameter between September 2014 and October 2016 were enrolled...
July 20, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28721979/histological-outcomes-between-hot-and-cold-snare-polypectomy-for-small-colorectal-polyps
#7
Toshiki Yamamoto, Sho Suzuki, Chika Kusano, Kyoko Yakabe, Maho Iwamoto, Hisatomo Ikehara, Takuji Gotoda, Mitsuhiko Moriyama
BACKGROUND/AIM: To compare the complete resection rate of hot and cold snare polypectomy for small colorectal polyps. PATIENTS AND METHODS: We retrospectively reviewed the medical records of 233 consecutive patients with 461 colorectal polyps up to 10 mm in diameter that were treated by hot or cold snare polypectomy between April 2014 and August 2016. Lesions treated by hot snare polypectomy (n = 137) and cold snare polypectomy (n = 324) were compared. The histological complete resection rates were evaluated between the two groups...
July 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/28713972/expression-and-subcellular-localization-of-at-motif-binding-factor-1-in-colon-tumours
#8
Hiromi Kataoka, Yutaka Miura, Makoto Kawaguchi, Shugo Suzuki, Yasuyuki Okamoto, Keiji Ozeki, Takaya Shimura, Tsutomu Mizoshita, Eiji Kubota, Satoshi Tanida, Satoru Takahashi, Kiyofumi Asai, Takashi Joh
AT motif binding factor 1 (ATBF1) is a transcriptional regulator that functions as a tumour suppressor to negatively affect cancer cell growth. In the present study four specific polyclonal antibodies against ATBF1 were generated, and the expression and intracellular localization of ATBF1 in colonic mucosae, polyps, adenoma and adenocarcinoma tissue samples were investigated. The four polyclonal antibodies produced were as follows: MB34 and MB49, which recognize the N‑ and C‑terminal fragments of ATBF1, respectively; and D1‑120 and MB44, which recognize the middle fragments of ATBF1 that contain three nuclear localization signals (NLS)...
September 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28710883/an-atypical-type-i-gastric-neuroendocrine-tumor
#9
Andrada-Viorela Gheorghe, Mihai Rimbas, Octav Ginghina, Andrada Spanu, Theodor Alexandru Voiosu
BACKGROUND: Gastric neuroendocrine tumors(GI-NETs) are rare lesions, usually discovered incidentally during endoscopy. Based on their pathology, there are 4 types of GI-NETs. Type I are multiple small polypoid lesions with central ulceration located in the gastric body or the fundus, associated with atrophic gastritis usually noninvasive and very rarely metastatic. We report on a rare case of a gastric NET arising from the muscularis propria layer of the pyloric ring. CASE REPORT: We present the case of a 65-year old woman with a history of alcoholic cirrhosis, investigated for melena...
July 14, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/28710577/detection-of-small-bowel-tumours-with-ct-enteroclysis-using-carbon-dioxide-and-virtual-enteroscopy-a-preliminary-study
#10
Anthony Dohan, Mourad Boudiaf, Xavier Dray, Elia Samaha, Christophe Cellier, Marine Camus, Clarisse Eveno, Raphael Dautry, Philippe Soyer
PURPOSE: The aim of this prospective study was to evaluate the feasibility, tolerance and performance of virtual enteroscopy (VE) using carbon dioxide for small-bowel distension in patients with suspected small-bowel tumours (SBTs). PATIENTS AND METHODS: After IRB approval, 17 patients with suspected SBTs were prospectively included. Radiation dose was compared to 34 matched patients (2 for 1) for age, gender and body weight, who had undergone CT-enteroclysis with neutral contrast (CTE)...
July 14, 2017: European Radiology
https://www.readbyqxmd.com/read/28705174/extensive-colorectal-lymphomatous-polyposis-complicated-by-acute-intestinal-obstruction-a-case-report
#11
Jaques Waisberg, Amanda do Val Anderi, Pedro Augusto Soffner Cardoso, José Henrique Miranda Borducchi, Demetrius Eduardo Germini, Maria Isete Fares Franco, Cidia Vasconcellos
BACKGROUND: Multiple lymphomatous polyposis is a rare type of gastrointestinal lymphoma that extensively infiltrates the intestine. Multiple lymphomatous polyposis originates from the mantle zone of the lymphoma follicle and is considered to be a mantle cell lymphoma, which is a relatively aggressive type of B-cell non-Hodgkin's lymphoma. We report an unusual case of a patient with multiple lymphomatous polyposis with extensive colorectal involvement and acute intestinal obstruction, an atypical complication of this rare disease...
July 13, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28689023/profiling-of-cytokines-chemokines-and-other-soluble-proteins-as-a-potential-biomarker-in-colorectal-cancer-and-polyps
#12
Nor Adzimah Johdi, Luqman Mazlan, Ismail Sagap, Rahman Jamal
Soluble proteins including cytokines, chemokines and growth factors are small proteins that mediate and regulate immunity. They involved in the pathogenesis of many diseases including cancers. The concentration of these proteins in biological fluids (serum or plasma) and tissues in diseases may suggest pathway activation that leads to inflammatory response or disease progression. Therefore, these soluble proteins may be useful as a tool for screening, diagnosis classification between stages of disease or surveillance for therapy...
July 6, 2017: Cytokine
https://www.readbyqxmd.com/read/28687028/adjunctive-use-of-chromoendoscopy-may-improve-the-diagnostic-performance-of-narrow-band-imaging-for-small-sessile-serrated-adenoma-polyp
#13
Li-Chun Chang, Chia-Hung Tu, Been-Ren Lin, Chia-Tung Shun, Weng-Feng Hsu, Jin-Tung Liang, Hsiu-Po Wang, Ming-Shiang Wu, Han-Mo Chiu
BACKGROUND AND AIMS: Endoscopic diagnosis of sessile serrated adenomas/polyps (SSA/P) is challenging because of their subtle appearance. Narrow-band imaging (NBI) is useful for diagnosis, but its utility with concurrent chromoendoscopy (CE), especially to detect small SSA/P, is unproven. PATIENTS AND METHODS: This prospective study enrolled 367 consecutive patients who underwent screening colonoscopy with the finding of serrated polyps. Patients were divided into derivation and validation cohorts: Diagnostic criteria using different endoscopic modalities were generated by regression analysis in the derivation cohort and were validated in the validation cohort for sensitivity, specificity, and accuracy...
July 7, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28685526/glycyrrhetinic-acid-suppressed-hmgb1-release-by-up-regulation-of-sirt6-in-nasal-inflammation
#14
D Chen, L M Bellussi, S Cocca, J Wang, G C Passali, X Hao, L Chen, D Passali
To extend our understanding of previous studies on the pathogenesis and mechanism of high mobility group box 1 (HMGB1) in chronic rhinosinusitis with nasal polyps (CRSwNP), here we show that Sirtuin 6 (Sirt6), one of the Sirtuin family members which are widely studied in aging, DNA repair, metabolism, inflammation and cancer, was expressed in normal nasal mucosa using immunohistochemical staining and Western blot assay. Sirt6 expression levels were decreased in CRSwNP tissue. Sirt6 expression levels were modulated by small interfering RNA transfection in human nasal epithelial cells (HNE)...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28685081/clinical-endoscopic-and-pathological-characteristics-of-colorectal-polyps-in-elderly-patients-single-center-experience
#15
Lei Zhou, Heng Zhang, Shengbin Sun, Manling Huang, Jing Liu, Dan Xu, Min Song, Chenming Sun, Hui Li, Dan Zheng, Yan Fan, Yusheng Liao, Ping Wang, Jie Wu
Increasing age is a risk factor for the development of colorectal adenomas and advanced adenomas. However, few studies have been published on the features of colorectal polyps in the elderly. The present study aimed to investigate the clinical, enteroscopic and pathological characteristics of colorectal polyps in Chinese elderly patients in a single center (The Central Hospital of Wuhan, Hubei, China). The endoscopic and pathological reports of colonoscopies performed in our center were retrospectively analyzed...
July 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28670615/cold-snare-polypectomy-reduced-delayed-postpolypectomy-bleeding-compared-with-conventional-hot-polypectomy-a-propensity-score-matching-analysis
#16
Takeshi Yamashina, Manabu Fukuhara, Takanori Maruo, Gensho Tanke, Saiko Marui, Ryota Sada, Mio Taki, Yoshiaki Ohara, Azusa Sakamoto, Shinichiro Henmi, Yugo Sawai, Sumio Saito, Norihiro Nishijima, Akihiro Nasu, Hideyuki Komekado, Akira Sekikawa, Masanori Asada, Takehiko Tumura, Ryuichi Kita, Toru Kimura, Yukio Osaki
BACKGROUND AND STUDY AIMS:  Cold snare polypectomy (CSP) for small colorectal polyps has lower incidence of adverse events, especially delayed postpolypectomy bleeding (DPPB). However, few data are available on comparisons of the incidence of DPPB of CSP and hot polypectomy (HP). The aim of this study was to evaluate the incidence of DPPB after CSP and compare it with that of HP. A propensity score model was used as a secondary analysis. PATIENTS AND METHODS:  This was a retrospective cohort study conducted in a single municipal hospital...
July 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28670614/efficacy-and-safety-of-cold-snare-resection-in-preventive-screening-colonoscopy
#17
B Schett, J Wallner, V Weingart, A Ayvaz, U Richter, J Stahl, H-D Allescher
BACKGROUND AND AIM:  Removal of polyps during colonoscopy effectively prevents the development of colorectal cancer. So far, snare resection with high frequency current with or without prior submucosal saline injection is the method of choice. The aim of this study was to evaluate the feasibility, safety, and outcome of cold snare resection during routine endoscopy. METHODS:  In this prospective study, 522 patients undergoing outpatient colonoscopy were included...
July 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28654863/stat6-promotes-intestinal-tumorigenesis-in-a-mouse-model-of-adenomatous-polyposis-by-expansion-of-mdscs-and-inhibition-of-cytotoxic-cd8-response
#18
Asha Jayakumar, Alfred L M Bothwell
Intestinal tumorigenesis in the ApcMin/+ model is initiated by aberrant activation of Wnt pathway. Increased IL-4 expression in human colorectal cancer tissue and growth of colon cancer cell lines implied that IL-4-induced Stat6-mediated tumorigenic signaling likely contributes to intestinal tumor progression in ApcMin/+ mice. Stat6 also appears to promote expansion of myeloid-derived suppressor cells (MDSCs) cells. MDSCs promote polyp formation in the ApcMin/+ model. Hence, Stat6 could have a broad role in coordinating both polyp cell proliferation and MDSC expansion...
August 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28652161/the-surgical-management-of-bladder-polyps-in-the-setting-of-exstrophy-epispadias-complex
#19
John Jayman, Ali Tourchi, Mahsa Shabaninia, Mahir Maruf, Heather DiCarlo, John P Gearhart
OBJECTIVE: To investigate the surgical course for treating bladder polyps in patients with exstrophy epispadias complex (EEC). EEC bladder polyps are unique pathologic entities, with a distinct difference between polyps discovered at birth and polyps developed after failed exstrophy closure. METHODS: A prospectively maintained database of 1300 patients with EEC was reviewed for bladder exstrophy patients with bladder polyps. The following data were obtained: patient demographics, polyp type, past medical and surgical history, and continence outcomes...
June 23, 2017: Urology
https://www.readbyqxmd.com/read/28647136/polypectomy-for-complete-endoscopic-resection-of-small%C3%A2-colorectal-polyps
#20
Qisheng Zhang, Peng Gao, Bin Han, Jianhua Xu, Yucui Shen
BACKGROUND AND AIMS: Small colorectal polyps are encountered frequently and may be incompletely removed during colonoscopy. The optimal technique for removal of small colorectal polyps is uncertain. The aim of this study was to compare the incomplete resection rate (IRR) by using EMR or cold snare polypectomy (CSP) for the removal of small adenomatous polyps. METHODS: This was a prospective randomized controlled study from a tertiary-care referral center. A total of 358 patients who satisfied the inclusion criteria (polyp sized 6-9 mm) were randomized to the EMR (n =179) and CSP (n =179) groups, and their polyps were treated with conventional EMR or CSP, respectively...
June 21, 2017: Gastrointestinal Endoscopy
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