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https://www.readbyqxmd.com/read/29035351/rebalancing-%C3%AE-amyloid-induced-decrease-of-atp-level-by-amorphous-nano-micro-polyphosphate-suppression-of-the-neurotoxic-effect-of-amyloid-%C3%AE-protein-fragment-25-35
#1
Werner E G Müller, Shunfeng Wang, Maximilian Ackermann, Meik Neufurth, Renate Steffen, Egherta Mecja, Rafael Muñoz-Espí, Qingling Feng, Heinz C Schröder, Xiaohong Wang
Morbus Alzheimer neuropathology is characterized by an impaired energy homeostasis of brain tissue. We present an approach towards a potential therapy of Alzheimer disease based on the high-energy polymer inorganic polyphosphate (polyP), which physiologically occurs both in the extracellular and in the intracellular space. Rat pheochromocytoma (PC) 12 cells, as well as rat primary cortical neurons were exposed to the Alzheimer peptide Aβ25-35. They were incubated in vitro with polyphosphate (polyP); ortho-phosphate was used as a control...
October 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28984298/polypoid-fibroadipose-tumors-of-the-esophagus-giant-fibrovascular-polyp-or-liposarcoma-a-clinicopathological-and-molecular-cytogenetic-study-of-13-cases
#2
Rondell P Graham, Saba Yasir, Karen J Fritchie, Michelle D Reid, Patricia T Greipp, Andrew L Folpe
Giant fibrovascular polyp of the esophagus is a descriptive diagnostic term intended to encompass rare, large, polypoid esophageal masses composed of fibroadipose tissue. Despite sometimes dramatic clinical presentations, they have historically been considered to represent reactive, non-neoplastic proliferations. Recently, however, a small number of reports have described well-differentiated liposarcomas of the esophagus, mimicking giant fibrovascular polyps. In order to clarify the relationship between esophageal liposarcoma and giant fibrovascular polyp, we retrieved esophageal cases coded as 'giant fibrovascular polyp,' 'lipoma' and 'liposarcoma' from our archives and re-examined their clinicopathologic features and MDM2 amplification status...
October 6, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28976027/underwater-endoscopic-mucosal-resection-of-an-intramucosal-carcinoma-located-from-the-lower-rectum-to-the-anal-canal
#3
Kenta Hamada, Noriya Uedo, Hitoshi Tanishita
A 62-year-old man with chronic renal failure was referred to our hospital for rectal polyp removal. Colonoscopy showed a 12-mm 0-Is+IIa lesion located from the lower rectum to the anal canal (Fig. 1a, b). The lesion looked small (<2 cm) and mostly benign. This article is protected by copyright. All rights reserved.
October 4, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28932094/comment-on-efficacy-and-adverse-events-of-cold-vs-hot-polypectomy-a-meta-analysis
#4
COMMENT
Huan-Huan Sun, Si-Lin Huang, Yang Bai
This is a comment on a meta-analysis of published studies comparing cold vs hot polypectomy. We believe that the conclusion of this meta-analysis that "cold polypectomy is a time-saving procedure for removing small polyps with markedly similar curability and safety to hot polypectomy" needs more rigorous evidence.
August 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28902739/high-definition-i-scan-colonoscopy-is-superior-in-the-detection-of-diminutive-polyps-compared-with-high-definition-white-light-colonoscopy-a-prospective-randomized-controlled-trial
#5
Jing Shan, Li Liu, Xiaobin Sun, Weidong Xi, Mei Yang, Yu Tang, Chunrong Ren, Wei Shi
INTRODUCTION: Recognition of flat and small neoplastic lesions by colonoscopy is still challenging. High-definition (HD) i-Scan colonoscopy is a promising technique to maximize the sensitivity of colonoscopy; however, whether i-Scan can increase the detection rate of polyps is still unclear. The aim of this study was to prospectively compare HD i-Scan colonoscopy with HD colonoscopy for the detection rate of polyps in routine practice. MATERIALS AND METHODS: A total of 449 patients who underwent total colonoscopy for the first time were randomized in a 1 : 1 ratio to undergo HD+i-Scan colonoscopy or HD colonoscopy...
November 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28898922/cold-versus-hot-endoscopic-mucosal-resection-for-nonpedunculated-colorectal-polyps-sized-6-10-mm-a-randomized-trial
#6
Vasilios Papastergiou, Konstantina D Paraskeva, Maria Fragaki, Ioannis Dimas, Emmanouil Vardas, Angeliki Theodoropoulou, Nicoletta Mathou, Athanasios Giannakopoulos, Konstantinos Karmiris, Afroditi Mpitouli, Dimitra Apessou, Linda Giannikaki, John A Karagiannis, Grigorios Chlouverakis, Gregorios A Paspatis
Background and study aims Cold snare polypectomy is an established method for the resection of small colorectal polyps; however, significant incomplete resection rates still leave room for improvement. We aimed to assess the efficacy of cold snare endoscopic mucosal resection (CS-EMR), compared with hot snare endoscopic mucosal resection (HS-EMR), for nonpedunculated polyps sized 6 - 10 mm. Patients and methods This study was a dual-center, randomized, noninferiority trial. Consecutive adult patients with at least one nonpedunculated polyp sized 6 - 10 mm were enrolled...
September 12, 2017: Endoscopy
https://www.readbyqxmd.com/read/28894821/the-role-of-infection-and-antibiotics-in-chronic-rhinosinusitis
#7
REVIEW
Miriam Baron Barshak, Marlene L Durand
OBJECTIVE: To review the current understanding of the role of infection and antibiotics in chronic rhinosinusitis. REVIEW METHODS: PubMed literature search. RESULTS: Chronic rhinosinusitis (CRS) in adults is an inflammatory condition and the role of infection is unclear. Biofilms are present in both CRS and normal patients so their role in CRS is unknown. Sinus cultures in CRS demonstrate a mixture of aerobic and anaerobic bacteria but may be hard to interpret due to contaminating nasal flora...
February 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/28888696/characterization-of-nvlwamide-like-neurons-reveals-stereotypy-in-nematostella-nerve-net-development
#8
Jamie A Havrilak, Dylan Faltine-Gonzalez, Yiling Wen, Daniella Fodera, Ayanna C Simpson, Craig R Magie, Michael J Layden
The organization of cnidarian nerve nets is traditionally described as diffuse with randomly arranged neurites that show minimal reproducibility between animals. However, most observations of nerve nets are conducted using cross-reactive antibodies that broadly label neurons, which potentially masks stereotyped patterns produced by individual neuronal subtypes. Additionally, many cnidarians species have overt structures such as a nerve ring, suggesting higher levels of organization and stereotypy exist, but mechanisms that generated that stereotypy are unknown...
September 6, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28882577/assessing-colon-polypectomy-competency-and-its-association-with-established-quality-metrics
#9
Anna M Duloy, Tonya R Kaltenbach, Rajesh N Keswani
BACKGROUND & AIMS: Inadequate polypectomy leads to incomplete resection, interval colorectal cancer, and adverse events. However, polypectomy competency is rarely reported and quality metrics are lacking. The primary aims of this study were to (1) assess polypectomy competency among a cohort of gastroenterologists, and (2) measure the correlation between polypectomy competency and established colonoscopy quality metrics (adenoma detection rate [ADR] and withdrawal time [WT]). METHODS: We conducted a prospective observational study to assess polypectomy competency amongst 13 high-volume screening colonoscopists at an academic medical center...
September 4, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28842049/management-of-small-bowel-polyps-a-literature-review
#10
REVIEW
Rabia A de Latour, Saikiran M Kilaru, Seth A Gross
Despite the small bowel comprising 90% of the mucosal surface area of the gastrointestinal tract, it is a rare site for neoplasia and only accounts for a little over 3% of the tumors that arise in the digestive tract. Benign small bowel lesions include lipomas, lymphangiomas, leiomyomas, neurofibromas, nodular lymphoid hyperplasia and adenomas, many of which are precursors to malignant lesions. Several polyposis syndromes are associated with small bowel polyps as well, including familial adenomatous polyposis syndrome, lynch syndrome, Peutz-Jeghers syndrome, Cowden syndrome and juvenile polyposis syndrome...
August 2017: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/28839893/endoscopic-approach-to-polyp-recognition
#11
Conor Lahiff, James E East
Identification and complete resection of colorectal polyps provide a significant mortality benefit from colorectal cancer. With improvements in colonoscopic techniques and advanced endoscopic imaging techniques, polyp detection has taken on greater complexity since the establishment of bowel cancer screening programmes internationally. All endoscopists operating within symptomatic and screening populations should be aware of endoscopic features associated with advanced neoplasia. Chromoendoscopy and advanced imaging techniques, such as narrow spectrum technologies (narrow band imaging, flexible spectral imaging colour enhancement (FICE) and i-Scan digital contrast (iSCAN)), have specific classification systems to support accurate lesion characterisation...
April 2017: Frontline Gastroenterology
https://www.readbyqxmd.com/read/28816375/adenocarcinoma-of-the-colon-presenting-as-a-submucosal-tumor
#12
Hourin Cho, Shigeki Sekine, Masau Sekiguchi
A 64-year-old woman underwent colonoscopy for abdominal discomfort and a protruded lesion measuring approximately 10 mm was detected in the descending colon. The tumor was entirely covered by normal-appearing mucosa and was regarded as a submucosal tumor (SMT). A small adenomatous polyp was present beside the SMT (Figure 1). For precise histological assessment of the SMT and therapeutic purpose of the coexisted polyp, we performed complete resection of the lesions by endoscopic submucosal dissection. This article is protected by copyright...
August 17, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28771607/il-25-induced-activation-of-nasal-fibroblast-and-its-association-with-the-remodeling-of-chronic-rhinosinusitis-with-nasal-polyposis
#13
Soo-Kyoung Park, Yong-De Jin, Yeong-Kyu Park, Sun-Hee Yeon, Jun Xu, Rui-Ning Han, Ki-Sang Rha, Yong-Min Kim
BACKGROUND AND OBJECTIVE: Interleukin (IL)-25 has been shown to play an important role in the pathogenesis of chronic rhinosinusitis with nasal polyps. Nasal polyps are associated with chronic inflammation of the mucous membranes in the paranasal sinuses and are involved in extracellular matrix (ECM) accumulation. The aim of this study is to evaluate the effects of IL-25 on myofibroblast differentiation, ECM production and the expression of matrix metalloproteinases in nasal polyp derived fibroblasts (NPDFs) and to determine the molecular mechanism underlying these processes...
2017: PloS One
https://www.readbyqxmd.com/read/28762356/antrochoanal-polyp-arising-from-benign-pseudocyst-of-maxillary-antrum
#14
Neha Keshri, Avi Bansal, Gourav Popli, Arvind Venkatesh, Siddhartha Goel
Antrochoanal polyps (ACPs) are benign lesions that arise from the mucosa of the maxillary antrum, grow into the maxillary sinus, and reach the choana with nasal obstruction being their main symptom. Most of these lesions are small and clinically silent and found as incidental finding, but large cysts which occupy the entire antrum have also been reported in literature. Nasal endoscopy and computer tomography (CT) are the golden standard in the diagnosis of ACPs, and enucleation by Caldwell-Luc approach is the recommended treatment for larger antral cysts...
July 2017: Journal of the Indian Society of Pedodontics and Preventive Dentistry
https://www.readbyqxmd.com/read/28758041/an-unusual-cause-of-intestinal-obstruction-in-a-young-adult-patient-inflammatory-fibroid-polyp
#15
Meryem Rais, Hafsa Chahdi, Mohammed Elfahssi, Abderrahmane Albouzidi, Mohamed Oukabli
Inflammatory fibroid polyps are uncommon benign lesions that originate in the submucosa of the gastrointestinal tract. The stomach and the ileum are the most commonly affected sites. Although inflammatory fibroid polyp is one of the rare conditions leading to intestinal obstruction in adults, it should be considered as a possible diagnosis in obstructive tumors of the small bowel causing intussusceptions. We present one case of inflammatory fibroid polyp as a rare cause of intussusception in a young adult patient...
2017: Case Reports in Surgery
https://www.readbyqxmd.com/read/28740967/incidental-gastrointestinal-stromal-tumor-at-a-gastroscopic-polypectomy-specimen-a-case-report-and-review-of-literature
#16
Dursun Özgür Karakaş, Özgür Dandin, Ahmet Ziya Balta, Yavuz Özdemir, İsmail Yılmaz, İlker Sücüllü
Although gastrointestinal stromal tumors (GISTs) comprise less than 1% of all gastrointestinal (GI) tract tumors, they are the most common mesenchymal tumors of the GI tract. Gastrointestinal stromal tumors can occur anywhere along the GI tract, but the stomach and small intestine are the most frequently involved sites. Gastrointestinal stromal tumors are frequently asymptomatic, and one-third of all cases are found incidentally. Endoscopy, endoscopic ultrasonography, and computed tomography are useful tools in the diagnosis...
2017: Turk J Surg
https://www.readbyqxmd.com/read/28730368/safety-of-cold-polypectomy-for-small-colorectal-neoplastic-lesions-a-prospective-cohort-study-in-japan
#17
Yuichi Shimodate, Motowo Mizuno, Rio Takezawa, Mami Kobayashi, Tatsuhiro Yamazaki, Akira Doi, Naoyuki Nishimura, Hirokazu Mouri, Kazuhiro Matsueda, Hiroshi Yamamoto
BACKGROUND: Cold polypectomy has been widely accepted for removal of small colorectal polyps. However, no large-scale prospective study exists as for its safety in Japan. We investigated this issue in this single-center, prospective cohort study in a total of 1198 colorectal polyps resected with cold polypectomy. PATIENTS AND METHODS: Four hundred and seventy-four patients who underwent cold polypectomy for colorectal neoplastic lesions less than 10-mm diameter between September 2014 and October 2016 were enrolled...
July 20, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28721979/histological-outcomes-between-hot-and-cold-snare-polypectomy-for-small-colorectal-polyps
#18
Toshiki Yamamoto, Sho Suzuki, Chika Kusano, Kyoko Yakabe, Maho Iwamoto, Hisatomo Ikehara, Takuji Gotoda, Mitsuhiko Moriyama
BACKGROUND/AIM: To compare the complete resection rate of hot and cold snare polypectomy for small colorectal polyps. PATIENTS AND METHODS: We retrospectively reviewed the medical records of 233 consecutive patients with 461 colorectal polyps up to 10 mm in diameter that were treated by hot or cold snare polypectomy between April 2014 and August 2016. Lesions treated by hot snare polypectomy (n = 137) and cold snare polypectomy (n = 324) were compared. The histological complete resection rates were evaluated between the two groups...
July 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/28713972/expression-and-subcellular-localization-of-at-motif-binding-factor-1-in-colon-tumours
#19
Hiromi Kataoka, Yutaka Miura, Makoto Kawaguchi, Shugo Suzuki, Yasuyuki Okamoto, Keiji Ozeki, Takaya Shimura, Tsutomu Mizoshita, Eiji Kubota, Satoshi Tanida, Satoru Takahashi, Kiyofumi Asai, Takashi Joh
AT motif binding factor 1 (ATBF1) is a transcriptional regulator that functions as a tumour suppressor to negatively affect cancer cell growth. In the present study four specific polyclonal antibodies against ATBF1 were generated, and the expression and intracellular localization of ATBF1 in colonic mucosae, polyps, adenoma and adenocarcinoma tissue samples were investigated. The four polyclonal antibodies produced were as follows: MB34 and MB49, which recognize the N‑ and C‑terminal fragments of ATBF1, respectively; and D1‑120 and MB44, which recognize the middle fragments of ATBF1 that contain three nuclear localization signals (NLS)...
September 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28710883/an-atypical-type-i-gastric-neuroendocrine-tumor
#20
Andrada-Viorela Gheorghe, Mihai Rimbas, Octav Ginghina, Andrada Spanu, Theodor Alexandru Voiosu
BACKGROUND: Gastric neuroendocrine tumors(GI-NETs) are rare lesions, usually discovered incidentally during endoscopy. Based on their pathology, there are 4 types of GI-NETs. Type I are multiple small polypoid lesions with central ulceration located in the gastric body or the fundus, associated with atrophic gastritis usually noninvasive and very rarely metastatic. We report on a rare case of a gastric NET arising from the muscularis propria layer of the pyloric ring. CASE REPORT: We present the case of a 65-year old woman with a history of alcoholic cirrhosis, investigated for melena...
July 14, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
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