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https://www.readbyqxmd.com/read/28219690/factors-associated-with-shorter-colonoscopy-surveillance-intervals-for-patients-with-low-risk-colorectal-adenomas-and-effects-on-outcome
#1
Joseph C Anderson, John A Baron, Dennis J Ahnen, Elizabeth L Barry, Roberd M Bostick, Carol A Burke, Robert S Bresalier, Timothy R Church, Bernard F Cole, Marcia Cruz-Correa, Adam S Kim, Leila A Mott, Robert S Sandler, Douglas J Robertson
BACKGROUND & AIMS: Endoscopists do not routinely follow guidelines to survey individuals with low-risk adenomas (LRAs, 1-2 small tubular adenomas, less than 1 cm) every 5-10 years for colorectal cancer (CRC)-many endoscopists recommend shorter surveillance intervals for these individuals. We aimed to identify reasons that endoscopists recommend shorter surveillance intervals for some individuals with LRAs and determine whether timing affects outcomes at follow-up examinations. METHODS: We collected data from 1560 individuals (45-75 years old) who participated in a prospective chemoprevention trial (of vitamin D and calcium) from 2004 through 2008...
February 17, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28205046/reproductive-factors-and-risk-of-colorectal-polyps-in-a-colonoscopy-based-study-in-western-washington-state
#2
Sheetal Hardikar, Andrea N Burnett-Hartman, Jessica Chubak, Melissa P Upton, Lee-Ching Zhu, John D Potter, Polly A Newcomb
BACKGROUND: Oral contraceptives (OC) are associated with a decreased risk of colorectal cancers; however, a recent study reported an increased risk of small colorectal adenomas associated with OC use. To determine if these results were replicable in a different study population, we investigated the relationship between OC use and other reproductive factors and risk of colorectal polyps in a case-control study in western Washington. METHODS: Study participants were 24-79-year-old female enrollees at an integrated health care system in western Washington who were diagnosed as having adenomas (n = 299), serrated polyps (n = 337), both types of polyps (n = 105) or as polyp-free controls (n = 615) through an index colonoscopy and completed a structured interview to collect reproductive history information...
February 15, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28197615/dietary-polyacetylenes-falcarinol-and-falcarindiol-isolated-from-carrots-prevents-the-formation-of-neoplastic-lesions-in-the-colon-of-azoxymethane-induced-rats
#3
Morten Kobaek-Larsen, Rime B El-Houri, Lars P Christensen, Issam Al-Najami, Xavier Fretté, Gunnar Baatrup
Falcarinol (FaOH) and falcarindiol (FaDOH) are found in many food plants of the Apiaceae family. Carrots are a major dietary source of these polyacetylenes. Feeding azoxymethane (AOM)-induced rats with carrots and purified FaOH have previously been shown to inhibit neoplastic transformations in the colon. FaOH and FaDOH have also shown to have a synergistic effect in vitro, resulting in a significant increased cytotoxic activity. Based on these findings the antineoplastic effect of FaOH and FaDOH (purity > 99%) was investigated in the AOM-induced rat model...
February 15, 2017: Food & Function
https://www.readbyqxmd.com/read/28192823/incomplete-resection-rate-of-cold-snare-polypectomy-a-prospective-single-arm-observational-study
#4
Noriko Matsuura, Yoji Takeuchi, Takeshi Yamashina, Takashi Ito, Kenji Aoi, Kengo Nagai, Takashi Kanesaka, Fumi Matsui, Mototsugu Fujii, Tomofumi Akasaka, Noboru Hanaoka, Koji Higashino, Yasuhiko Tomita, Yuri Ito, Ryu Ishihara, Hiroyasu Iishi, Noriya Uedo
Background and study aims Cold snare polypectomy (CSP) is considered to be safe for the removal of subcentimeter colorectal polyps. This study aimed to determine the rate of incomplete CSP resection for subcentimeter neoplastic polyps at our center. Patients and methods Patients with small or diminutive adenomas (diameter 1 - 9 mm) were recruited to undergo CSP until no polyp was visible. After CSP, a 1 - 3 mm margin around the resection site was removed using endoscopic mucosal resection. The polyps and resection site marginal specimens were microscopically evaluated...
February 13, 2017: Endoscopy
https://www.readbyqxmd.com/read/28184053/gastrointestinal-diseases-and-their-oro-dental-manifestations-part-4-peutz-jeghers-syndrome
#5
S E Korsse, M E van Leerdam, E Dekker
Peutz-Jeghers syndrome (PJS) is a rare, autosomal dominant inherited disorder, caused by germline mutations in the LKB1 tumour suppressor gene. It is clinically characterised by distinct perioral mucocutaneous pigmentations, gastrointestinal polyposis and an increased cancer risk in adult life. Hamartomatous polyps can develop already in the first decade of life and may cause various complications, including abdominal pain, bleeding, anaemia, and acute intestinal obstruction. Furthermore, patients have an increased risk for developing cancer, both in the gastrointestinal tract as in other organs...
February 10, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28178153/case-report-malignant-transformation-in-cronkhite-canada-syndrome-polyp
#6
Ye Zong, Haiying Zhao, Li Yu, Ming Ji, Yongdong Wu, Shutian Zhang
RATIONALE: Cronkhite-Canada syndrome (CCS) is a rare disease, the etiology of CCS is currently unknown. Although CCS is widely accepted as a benign disorder, the malignant potential of the polyps in CCS patients is yet controversial. PATIENT CONCERNS: A 55-year-old Chinese male was first admitted to Beijing Friendship Hospital with a 3-month history of frequent watery diarrhea (10-15 times/day), loss of taste, and a weight loss of 10 kg in August 2010. The left heel bone fracture in the patient occurred about 2 weeks prior to his diarrhea...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28177992/limited-endoscopic-assisted-wedge-resection-for-excision-of-colon-polyps
#7
Laura W Leicher, Wouter H de Vos Tot Nederveen Cappel, Henderik L van Westreenen
BACKGROUND: Combined endoscopic laparoscopic surgical removal is used for polyps in the colon that are not suitable for endoscopic removal because of size, location, or scarring. However, the placement of a linear stapler can be challenging. Currently a wedge resection is mostly documented in the cecum or ascending colon. OBJECTIVE: We report on our experience with limited endoscopy-assisted wedge resections in the entire colon. DESIGN: A retrospective study was performed...
March 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28177905/trap1-protein-signature-predicts-outcome-in-human-metastatic-colorectal-carcinoma
#8
Francesca Maddalena, Vittorio Simeon, Giulia Vita, Annamaria Bochicchio, Luciana Possidente, Lorenza Sisinni, Giacomo Lettini, Valentina Condelli, Danilo Swann Matassa, Valeria Li Bergolis, Alberto Fersini, Sante Romito, Michele Aieta, Antonio Ambrosi, Franca Esposito, Matteo Landriscina
TRAP1 is a HSP90 molecular chaperone upregulated in colorectal carcinomas and involved in control of intracellular signaling, cell cycle, apoptosis and drug resistance, stemness and bioenergetics through co-traslational regulation of a network of client proteins. Thus, the clinical significance of TRAP1 protein network was analyzed in human colorectal cancers. TRAP1 and/or its client proteins were quantified, by immunoblot analysis, in 60 surgical specimens of colorectal carcinomas at different stages and, by immunohistochemistry, in 9 colorectal adenomatous polyps, 11 in situ carcinomas and 55 metastatic colorectal tumors...
February 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28160514/deep-learning-for-polyp-recognition-in-wireless-capsule-endoscopy-images
#9
Yixuan Yuan, Max Q-H Meng
PURPOSE: Wireless Capsule Endoscopy (WCE) enables physicians to examine the digestive tract without any surgical operations, at the cost of a large volume of images to be analyzed. In the computer-aided diagnosis of WCE images, the main challenge arisesfrom the difficulty of robust characterization of images. This study aims to provide dis-criminative description of WCE images and assist physicians to recognize polyp images automatically. METHODS: We propose a novel deep feature learning method, named stacked sparse autoencoder with image manifold constraint (SSAEIM), to recognize polyps in the WCE images...
February 4, 2017: Medical Physics
https://www.readbyqxmd.com/read/28154273/the-features-of-colorectal-tumors-in-a-patient-with-li-fraumeni-syndrome
#10
Tsukasa Yoshida, Masahiro Tajika, Tsutomu Tanaka, Makoto Ishihara, Yutaka Hirayama, Nobumasa Mizuno, Kazuo Hara, Susumu Hijioka, Hiroshi Imaoka, Nobuhiro Hieda, Nozomi Okuno, Takashi Kinoshita, Vikram Bhatia, Yasuhiro Shimizu, Yasushi Yatabe, Kenji Yamao, Yasumasa Niwa
A young woman with Li-Fraumeni syndrome (LFS) was referred to our hospital. On examination, multiple flat neoplasms were detected in addition to semi-pedunculated polyps. Restorative proctocolectomy was performed; one submucosal invasive cancer, two mucosal cancers, and several adenomas with high-grade dysplasia were detected. On immunohistochemical staining with p53, every part of all neoplasms, even the small adenomas, showed strong positive staining. Multiple flat neoplasms may be characteristic of patients with LFS and may have a much higher risk of rapid progression to invasive carcinomas than sporadic neoplasms...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28147305/the-heparanase-inhibitor-pg545-attenuates-colon-cancer-initiation-and-growth-associating-with-increased-p21-expression
#11
Preeti Singh, Alexandra Blatt, Sari Feld, Yaniv Zohar, Esraa Saadi, Liza Barki-Harrington, Edward Hammond, Neta Ilan, Israel Vlodavsky, Yehuda Chowers, Elizabeth Half
Heparanase activity is highly implicated in cellular invasion and tumor metastasis, a consequence of cleavage of heparan sulfate and remodeling of the extracellular matrix underlying epithelial and endothelial cells. Heparanase expression is rare in normal epithelia, but is often induced in tumors, associated with increased tumor metastasis and poor prognosis. In addition, heparanase induction promotes tumor growth, but the molecular mechanism that underlines tumor expansion by heparanase is still incompletely understood...
January 29, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28134634/delayed-bleeding-following-cold-snare-polypectomy-for-small-colorectal-polyps-in-patients-taking-antithrombotic-agents
#12
Toshiyuki Makino, Akira Horiuchi, Masashi Kajiyama, Naoki Tanaka, Kenji Sano, Iruru Maetani
BACKGROUND: This study compared the incidence of delayed bleeding following 2 methods of cold snare polypectomy for colorectal polyps in patients taking antithrombotic agents. METHODS: Patients undergoing cold snare polypectomy for colorectal polyps ≤10 mm without discontinuation of antithrombotic agents were enrolled. This was a retrospective study of a prospectively collected cohort based on a historical comparison of 2 time periods. A traditional cold snare was used between January 2012 and December 2013 and a dedicated cold snare was used between January 2014 and December 2015...
January 27, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28125785/ct-colonographic-screening-of-patients-with-a-family-history-of-colorectal-cancer-comparison-with-adults-at-average-risk-and-implications-for-guidelines
#13
Perry J Pickhardt, Ifeanyi Mbah, B Dustin Pooler, Oliver T Chen, J Louis Hinshaw, Jennifer M Weiss, David H Kim
OBJECTIVE: The purposes of this study were to compare rates of lesion detection at CT colonographic (CTC) screening of adults without symptoms who had and who did not have a family history of colorectal cancer according to American Cancer Society guidelines and to consider the clinical implications. MATERIALS AND METHODS: Over 134 months, consecutively registered CTC cohorts of adults without symptoms who had (n = 156; 88 [56.4%] women; 68 [43.6%] men; mean age, 56...
January 26, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28124643/rapamycin-inhibits-transforming-growth-factor-beta-1-induced-myofibroblast-differentiation-via-the-phosphorylated-phosphatidylinositol-3-kinase-mammalian-target-of-rapamycin-signal-pathways-in-nasal-polyp-derived-fibroblasts
#14
Dong-Yn Ko, Jae-Min Shin, Ji-Young Um, Byungjin Kang, Il-Ho Park, Heung-Man Lee
PURPOSE: Rapamycin has antiproliferative and antifibrogenic effects in vitro and in vivo. The purpose of this study was to evaluate the effects of rapamycin on transforming growth factor (TGF) beta 1 induced myofibroblast differentiation (alpha smooth-muscle actin [SMA]), extracellular matrix production, and collagen contraction in nasal polyp-derived fibroblasts (NPDF). The underlying molecular mechanisms of rapamycin were also determined in NPDFs. METHODS: NPDFs were grown in culture and transformed into myofibroblasts by using TGF beta 1 (5 ng/mL)...
November 1, 2016: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/28116488/antibiofilm-effects-of-topical-corticosteroids-and-intranasal-saline-in-patients-with-chronic-rhinosinusitis-with-nasal-polyps-depend-on-bacterial-species-and-their-biofilm-forming-capacity
#15
Ivana Cirkovic, Bojan Pavlovic, Dragana D Bozic, Ana Jotic, Ljubica Bakic, Jovica Milovanovic
Microbial biofilms have been implicated in the pathogenesis of chronic rhinosinusitis with nasal polyposis (CRSwNP). Intranasal application of corticosteroids and saline is a reliable option for their management. The aim of our study was to evaluate in vitro antibiofilm effects of corticosteroids and isotonic and hypertonic nasal saline in CRSwNP patients. The sinus mucosal specimens were harvested from the ethmoid cavity of 48 patients with CRSwNP and further subjected to hematoxylin-eosin staining and microbiology analysis...
January 23, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28114040/automatic-detection-and-classification-of-colorectal-polyps-by-transferring-low-level-cnn-features-from-nonmedical-domain
#16
Ruikai Zhang, Yali Zheng, Tony Wing Chung Mak, Ruoxi Yu, Sunny H Wong, James Y W Lau, Carmen C Y Poon
Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. Although polypectomy at early stage reduces CRC incidence, 90% of the polyps are small and diminutive, where removal of them poses risks to patients that may outweigh the benefits. Correctly detecting and predicting polyp type during colonoscopy allows endoscopists to resect and discard the tissue without submitting it for histology, saving time, and costs. Nevertheless, human visual observation of early stage polyps varies. Therefore, this paper aims at developing a fully automatic algorithm to detect and classify hyperplastic and adenomatous colorectal polyps...
January 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28104992/ileo-ileal-intussusception-caused-by-lymphangioma-of-the-small-bowel-treated-by-single-incision-laparoscopic-assisted-ileal-resection
#17
Atsushi Kohga, Akihiro Kawabe, Yuto Hasegawa, Kiyoshige Yajima, Takuya Okumura, Kimihiro Yamashita, Jun Isogaki, Kenji Suzuki, Akira Komiyama
Intraabdominal lymphangiomas are uncommon; additionally, those affecting the gastrointestinal tract are rare and account for less than 1% of cases. Intussusception caused by a cystic lymphangioma of the small bowel is extremely rare. The patient was a 20-year-old woman who visited our emergency room with a complaint of abdominal pain. A computed tomography image revealed ileo-ileal intussusception with a leading hypovascular mass measuring 1 cm in a diameter. Single-incision laparoscopic-assisted ileal resection was performed...
January 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28079233/suspected-blood-indicator-in-capsule-endoscopy-a-valuable-tool-for-gastrointestinal-bleeding-diagnosis
#18
Pedro Boal Carvalho, Joana Magalhães, Francisca Dias DE Castro, Sara Monteiro, Bruno Rosa, Maria João Moreira, José Cotter
BACKGROUND: Small bowel bleeding is a leading indication for small bowel capsule endoscopy. The Suspected Blood Indicator (SBI) is a software feature directed to automatically detect bleeding lesions during small bowel capsule endoscopy. OBJECTIVE: - We aimed to assess SBI diagnostic accuracy for small bowel haemorrhage or potentially bleeding lesions during small bowel capsule endoscopy for small bowel bleeding. Methods - Single-centre retrospective study including 281 consecutive small bowel capsule endoscopy performed for small bowel bleeding during 6 years...
January 2017: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/28072748/giant-polypoid-gastric-heterotopia-in-the-small-intestine-in-a-boy-a-case-report-and-literature-review
#19
Jing Cai, Haibo Yu
RATIONALE: Heterotopic gastric mucosa has been described at various locations of the body; however, the polyp composed of heterotopic gastric mucosa in the small intestine is rare. PATIENT CONCERNS: A 15-year-old boy visited us for investigation of recurrent episodes of melena. Capsule endoscopy (CE) revealed a polypoid tumor in the ileum, with an active nearby hemorrhage. Contrast-enhanced computed tomography (CECT) showed a tumor in the right quadrant of the abdomen, with a diameter of about 18 × 14 mm...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28038683/the-gut-microbiota-in-conventional-and-serrated-precursors-of-colorectal-cancer
#20
Brandilyn A Peters, Christine Dominianni, Jean A Shapiro, Timothy R Church, Jing Wu, George Miller, Elizabeth Yuen, Hal Freiman, Ian Lustbader, James Salik, Charles Friedlander, Richard B Hayes, Jiyoung Ahn
BACKGROUND: Colorectal cancer is a heterogeneous disease arising from at least two precursors-the conventional adenoma (CA) and the serrated polyp. We and others have previously shown a relationship between the human gut microbiota and colorectal cancer; however, its relationship to the different early precursors of colorectal cancer is understudied. We tested, for the first time, the relationship of the gut microbiota to specific colorectal polyp types. RESULTS: Gut microbiota were assessed in 540 colonoscopy-screened adults by 16S rRNA gene sequencing of stool samples...
December 30, 2016: Microbiome
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