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https://www.readbyqxmd.com/read/29780508/identifying-key-descriptors-in-surface-binding-interplay-of-surface-anchoring-and-intermolecular-interactions-for-carboxylates-on-au-110
#1
Christopher R O'Connor, Fanny Hiebel, Wei Chen, Efthimios Kaxiras, Robert J Madix, Cynthia M Friend
The relative stability of carboxylates on Au(110) was investigated as part of a comprehensive study of adsorbate binding on Group IB metals that can be used to predict and understand how to control reactivity in heterogeneous catalysis. The binding efficacy of carboxylates is only weakly dependent on alkyl chain length for relatively short-chain molecules, as demonstrated using quantitative temperature-programmed reaction spectroscopy. Corresponding density functional theory (DFT) calculations demonstrated that the bidentate anchoring geometry is rigid and restricts the amount of additional stabilization through adsorbate-surface van der Waals (vdW) interactions which control stability for alkoxides...
April 21, 2018: Chemical Science
https://www.readbyqxmd.com/read/29775691/pain-in-maintenance-hemodialysis-patients-a-multicenter-study
#2
Tatiana Talya Fleishman, Jacob Dreiher, Pesach Shvartman
CONTEXT: Pain is a common complaint in maintenance hemodialysis (MHD) patients, yet is often inadequately assessed and undertreated. OBJECTIVES: To evaluate the prevalence, characteristics, intensity, and impact of pain in MHD patients. METHODS: In a cross-sectional study conducted between 2013 and 2015, 336 MHD patients from five hemodialysis units in hospitals owned by Clalit were interviewed and evaluated. Study tools included the Brief Pain Inventory, The Leeds Assessment of Neuropathic Symptoms and Signs pain scale, demographic and clinical characteristics...
May 15, 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29754075/corrigendum-to-optimization-of-physicochemical-properties-for-4-anilinoquinazoline-inhibitors-of-trypanosome-proliferation-eur-j-med-chem-141-2017-446-459
#3
Jennifer L Woodring, Kelly A Bachovchin, Kimberly G Brady, Mitchell F Gallerstein, Jessey Erath, Scott Tanghe, Susan E Leed, Ana Rodriguez, Kojo Mensa-Wilmot, Richard J Sciotti, Michael P Pollastri
No abstract text is available yet for this article.
May 10, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29741462/complications-risk-factors-and-patients-reported-outcomes-after-skin-sparing-mastectomy-followed-by-breast-reconstruction-in-women-with-brca-mutations
#4
Ingvild O Moberg, Inger Schou Bredal, Michael R Schneider, Kim A Tønseth, Ellen Schlichting
BACKGROUND: Women with a BRCA mutation have the option of undergoing prophylactic mastectomy and immediate breast reconstruction; however, the potential negative effects of reconstruction on women's physical and psychological well-being are unclear. This study aimed to investigate complications, patient-reported pain, health-related quality-of-life (HRQoL) and satisfaction following reconstructive surgery at Oslo University Hospital between 2006 and 2013. METHODS: Data were collected retrospectively from the records of 238 patients...
May 9, 2018: Journal of Plastic Surgery and Hand Surgery
https://www.readbyqxmd.com/read/29733398/pre-pregnancy-fast-food-and-fruit-intake-is-associated-with-time-to-pregnancy
#5
Jessica A Grieger, Luke E Grzeskowiak, Tina Bianco-Miotto, Tanja Jankovic-Karasoulos, Lisa J Moran, Rebecca L Wilson, Shalem Y Leemaqz, Lucilla Poston, Lesley McCowan, Louise C Kenny, Jenny Myers, James J Walker, Robert J Norman, Gus A Dekker, Claire T Roberts
STUDY QUESTION: Is preconception dietary intake associated with reduced fecundity as measured by a longer time to pregnancy (TTP)? SUMMARY ANSWER: Lower intake of fruit and higher intake of fast food in the preconception period were both associated with a longer TTP. WHAT IS KNOWN ALREADY: Several lifestyle factors, such as smoking and obesity, have consistently been associated with a longer TTP or infertility, but the role of preconception diet in women remains poorly studied...
May 4, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29732994/towards-standardized-stem-cell-therapy-in-type-2-diabetes-mellitus-a-systematic-review
#6
Jeanne Adiwinata Pawitan, Zheng Yang, Ying Nan Wu, Eng Hin Leed
OBJECTIVE: To compile and analyze the published studies on cell therapy for type 2 diabetes mellitus (T2DM) to obtain a better insight into management of T2DM that involved stem cell therapy. METHODS: We searched all published studies in Pubmed/Medline, and Cochrane library, using keywords: 'stem cell' AND 'therapy' AND 'diabetes type 2'. INCLUSION CRITERIA: original articles on the use of stem cells in humans with T2DM. EXCLUSION CRITERIA: articles in the non-English literature, studies on T2DM complications that did not assess both adverse events and any of the common diabetes study outcomes...
May 2, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29732728/dyspepsia-in-non-steroidal-anti-inflammatory-drug-users-and-the-effect-of-preventive-measures
#7
Hooi Leng Lee, Siew Siang Chua, Sanjiv Mahadeva
BACKGROUND/AIMS: Dyspepsia is the commonest gastrointestinal (GI) adverse effect of non-steroidal anti-inflammatory drugs (NSAID). The effects of preventive measures and their adherence from a real-world perspective have been little reported. METHODS: A prospective longitudinal study was conducted among outpatients with regular NSAID usage. The presence of dyspepsia (assessed by locally validated versions of the Leeds Dyspepsia Questionnaire (LDQ), gastric preventive agents (GPA) and their adherence were assessed at recruitment and two weeks later...
May 7, 2018: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29732504/femoral-offset-found-not-to-affect-metal-ion-levels-in-metal-on-metal-total-hip-arthroplasty
#8
Eoghan Pomeroy, Fergal Macnamara, Evelyn Murphy, Niall McGoldrick, Anant Mahapatra, Nasir Awan
BACKGROUND: Failure to restore femoral offset in metal on polyethylene total hip arthroplasty (THA) causes polyethylene wear and aseptic loosening. To our knowledge, no study to date has investigated the relationship between femoral offset and wear in metal-on-metal (MOM) THA. AIMS: In this study, we investigated the relationship between femoral offset and wear by measuring circulating metal ion levels in MOM THA. METHODS: In this retrospective study, we identified patients who had undergone MOM THA with the ASR XL system (DePuy International Ltd...
May 7, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29731609/attitudes-toward-concordance-and-self-efficacy-in-decision-making-a-cross-sectional-study-on-pharmacist-patient-consultations
#9
Yew Keong Ng, Noraida Mohamed Shah, Ly Sia Loong, Lay Ting Pee, Sarina Anim M Hidzir, Wei Wen Chong
Purpose: This study investigated patients' and pharmacists' attitudes toward concordance in a pharmacist-patient consultation and how patients' attitudes toward concordance relate to their involvement and self-efficacy in decision making associated with medication use. Subjects and methods: A cross-sectional study was conducted among patients with chronic diseases and pharmacists from three public hospitals in Malaysia. The Revised United States Leeds Attitudes toward Concordance (RUS-LATCon) was used to measure attitudes toward concordance in both patients and pharmacists...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29730633/use-of-a-gp-endorsed-12-months-reminder-letter-to-promote-uptake-of-bowel-scope-screening-protocol-for-a-randomised-controlled-trial-in-a-hard-to-reach-population
#10
Christian von Wagner, Yasemin Hirst, Sara Tookey, Robert S Kerrison, Sarah Marshall, Andrew Prentice, Daniel Vulkan, Una Macleod, Stephen Duffy
INTRODUCTION: Flexible sigmoidoscopy (FS) screening is associated with reduced colorectal cancer incidence and mortality when offered as a one-off test to men and women aged 55-64. The test, also referred to as the 'bowel scope screening' (BSS) test, was added to England's national Bowel Cancer Screening Programme in March 2013, where it is offered to men and women aged 55. Since its implementation, uptake of the BSS test has been low, with only 43% of the eligible population attending an appointment...
May 5, 2018: BMJ Open
https://www.readbyqxmd.com/read/29721066/amino-acid-uptake-measured-by-18-f-afetp-increases-in-response-to-arginine-starvation-in-ass1-deficient-sarcomas
#11
Bethany Cheree Prudner, Fangdi Sun, Jeffrey Charles Kremer, Jinbin Xu, Chaofeng Huang, Kiran Kumar Solingapuram Sai, Zachary Morgan, Hayden Leeds, Jonathan McConathy, Brian Andrew Van Tine
Rational : In a subset of cancers, arginine auxotrophy occurs due to the loss of expression of argininosuccinate synthetase 1 (ASS1). This loss of ASS1 expression makes cancers sensitive to arginine starvation that is induced by PEGylated arginine deiminase (ADI-PEG20). Although ADI-PEG20 treatment is effective, it does have important limitations. Arginine starvation is only beneficial in patients with cancers that are ASS1-deficient. Also, these tumors may metabolically reprogram to express ASS1, transforming them from an auxotrophic phenotype to a prototrophic phenotype and thus rendering ADI-PEG20 ineffective...
2018: Theranostics
https://www.readbyqxmd.com/read/29718965/comparison-of-pain-burden-and-psychological-factors-in-brazilian-women-living-with-hiv-and-chronic-neuropathic-or-nociceptive-pain-an-exploratory-study
#12
Andressa de Souza, Wolnei Caumo, Prisla Ucker Calvetti, Rachel Nunes Lorenzoni, Gisele Keller da Rosa, Alexandre Ramos Lazzarotto, Jairo Alberto Dussan-Sarria
Psychological factors including pain catastrophizing and resilience associate with adjustment and quality of life in people living with chronic pain. Nevertheless, their presentation among females living with HIV and chronic pain has been poorly studied. Given that chronic pain in those living with HIV might occur due to different mechanisms (nociceptive or neuropathic), we hypothesize that the associated psychological states could also differ between these groups. We aimed to compare pain frequency and interference, psychological factors and sleep quality between females living with chronic nociceptive or neuropathic pain...
2018: PloS One
https://www.readbyqxmd.com/read/29718144/genomic-surveillance-reveals-diversity-of-multidrug-resistant-organism-colonization-and-infection-a-prospective-cohort-study-in-liver-transplant-recipients
#13
Nenad Macesic, Angela Gomez-Simmonds, Sean B Sullivan, Marla J Giddins, Samantha A Ferguson, Gautam Korakavi, David Leeds, Sarah Park, Kevin Shim, Madeleine G Sowash, Melanie Hofbauer, Ryan Finkel, Yue Hu, Jared West, Nora C Toussaint, William G Greendyke, Benjamin A Miko, Marcus R Pereira, Susan Whittier, Elizabeth C Verna, Anne-Catrin Uhlemann
Background: Multidrug-resistant organisms (MDROs) are an important cause of morbidity and mortality after solid organ transplantation. We aimed to characterize MDRO colonization dynamics and infection in liver transplant (LT) recipients through innovative use of active surveillance and whole-genome sequencing (WGS). Methods: We prospectively enrolled consecutive adult patients undergoing LT from March 2014 to March 2016. Fecal samples were collected at multiple timepoints from time of enrollment to 12 months posttransplant...
April 28, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29716577/is-adolescent-body-mass-index-and-waist-circumference-associated-with-the-food-environments-surrounding-schools-and-homes-a-longitudinal-analysis
#14
Mark A Green, Duncan Radley, Nik Lomax, Michelle A Morris, Claire Griffiths
BACKGROUND: There has been considerable interest in the role of access to unhealthy food options as a determinant of weight status. There is conflict across the literature as to the existence of such an association, partly due to the dominance of cross-sectional study designs and inconsistent definitions of the food environment. The aim of our study is to use longitudinal data to examine if features of the food environment are associated to measures of adolescent weight status. METHODS: Data were collected from secondary schools in Leeds (UK) and included measurements at school years 7 (ages 11/12), 9 (13/14), and 11 (15/16)...
May 2, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29713676/novel-temperature-controlled-rfa-probe-for-treatment-of-blocked-metal-biliary-stents-in-patients-with-pancreaticobiliary-cancers-initial-experience
#15
Manu K Nayar, Kofi W Oppong, Noor L H Bekkali, John S Leeds
Background and study aims:  Radiofrequency ablation (RFA) is used to treat blocked biliary stents in patients with pancreaticobiliary (PB) tumors with varying results. We report our experience with a novel temperature-controlled probe for treatment of blocked metal stents. Patients and methods:  Patients with histologically proven PB cancers and a blocked biliary stents were treated using ELRATM electrode (Taewoong Medical) under fluoroscopic guidance. Demographics, clinical outcome, stricture diameter improvements, complications and mortality at 30 days were prospectively recorded...
May 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29710345/limitations-of-the-national-cancer-data-base-to-evaluate-early-stage-anal-cancer-treatment-outcomes
#16
Ira L Leeds, Sandy H Fang
No abstract text is available yet for this article.
April 25, 2018: JAMA Surgery
https://www.readbyqxmd.com/read/29692922/-18-f-fdopa-pet-mri-for-monitoring-early-response-to-bevacizumab-in-children-with-recurrent-brain-tumors
#17
Karen Gauvain, Maria Rosana Ponisio, Amy Barone, Michael Grimaldi, Ephraim Parent, Hayden Leeds, Manu Goyal, Joshua Rubin, Jonathan McConathy
Background: Noninvasively predicting early response to therapy in recurrent pediatric brain tumors provides a challenge. 3,4-dihydroxy-6-[18 F]fluoro-L-phenylalanine (18 F-FDOPA) PET/MRI has not been previously studied as a tool to evaluate early response to antiangiogenic therapy in children. The purpose of this study was to evaluate the safety and feasibility of using 18 F-FDOPA PET/MRI to assess response to bevacizumab in children with relapsed brain tumors. Materials and Methods: Six patients with recurrent gliomas (5 low-grade, 1 high-grade) planned to undergo treatment with bevacizumab were enrolled...
March 2018: Neuro-oncology Practice
https://www.readbyqxmd.com/read/29691771/neuropathic-pain-is-it-an-underestimated-symptom-in-systemic-sclerosis
#18
Nihan Cuzdan, Ipek Turk, Tunay Sarpel, Eren Erken, Zeliha Nazan Alparslan
Pain is one of the most common symptoms in systemic sclerosis (SSc) patients, yet not considered in the assessment of disease severity. This study aimed to investigate the frequency of neuropathic pain (NP) and to evaluate its interference with the quality of life (QoL) in SSc patients. Diffuse and Limited SSc patients diagnosed by American College of Rheumatology 2013 criteria were included in the study. Pain was evaluated with Visual Analogue Scale (VAS); presence of NP was screened with The Leeds Assessment of Neuropathic Symptoms and Signs (LANNS) questionnaire; disease activity was evaluated with modified Medsger Severity Scale (MSS) and QoL with short-form 36 (SF-36)...
April 24, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29686922/endolumenal-vacuum-therapy-and-fistulojejunostomy-in-the-management-of-sleeve-gastrectomy-staple-line-leaks
#19
Kyle Szymanski, Estrellita Ontiveros, James S Burdick, Daniel Davis, Steven G Leeds
Laparoscopic sleeve gastrectomy (LSG) is the most common bariatric surgery performed for morbid obesity. Leaks of the vertical staple line can occur in up to 7% of cases and are difficult to manage. Endolumenal vacuum (EVAC) therapy and fistulojejunostomy (FJ) have separate documented uses to heal these complicated leaks. We aim to show the benefit of using EVAC with FJ in the treatment of LSG staple line leaks. The patient presented with an LSG chronic leak. EVAC therapy was initiated but failed to close the fistula after 101 days...
2018: Case Reports in Surgery
https://www.readbyqxmd.com/read/29679958/chemical-waves-in-the-o-2-h-2-reaction-on-a-rh-111-surface-alloyed-with-nickel-i-photoelectron-emission-microscopy
#20
Tim Smolinsky, Bernhard von Boehn, Ronald Imbihl
Chemical waves that arise in the H2 + O2 reaction on a bimetallic Rh(111)/Ni surface have been studied in the 10-6 and 10-5 mbar range at T = 773 K with photoelectron emission microscopy (PEEM), low-energy electron diffraction (LEED), and Auger electron spectroscopy (AES). Nickel coverages of 0.3, 0.6, and 1.0 monolayers were investigated. Coadsorbed with some oxygen, Ni starts to penetrate the Rh bulk region substantially only beyond 900 K. In the 10-5 mbar range, chemical waves are characterized by three distinct gray levels in PEEM...
April 21, 2018: Journal of Chemical Physics
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