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https://www.readbyqxmd.com/read/29160630/synthetic-grafts-in-the-treatment-of-ruptured-anterior-cruciate-ligament-of-the-knee-joint
#1
REVIEW
Wojciech Satora, Aleksandra Królikowska, Andrzej Czamara, Paweł Reichert
The anterior cruciate ligament (ACL) is cited as the most frequently injured ligament in the knee. The standard treatment of ACL injury remains ligament reconstruction followed by a postoperative physiotherapeutic procedure. During the reconstruction, the torn ligament can be replaced with an autograft or an allograft. A synthetic ligament is also one of the available graft options. Synthetic grafts in ruptured ACL treatment have been used as scaffolds, stents, or prostheses. The story of using synthetic materials in ACL deficient knee treatment started in the beginning of the 20th century with the usage of silk and silver fibers...
January 2017: Polimery W Medycynie
https://www.readbyqxmd.com/read/29150988/patterns-and-correlates-of-grip-strength-in-older-americans
#2
Kimberly Forrest, Adelle Williams, Marcy Leeds, Joseph Robare, Thomas Bechard
BACKGROUND: Muscle strength is a sensitive indicator of morbidity and mortality in older adults. Loss of muscle strength contributes to a decline in physical functioning. Hand grip strength is a simple measurement but correlated with total body muscle strength. This study evaluated the patterns and correlates of grip strength among older adults in the United States. METHODS: The grip strength data were analyzed from the National Health and Nutrition Examination Survey...
November 16, 2017: Current Aging Science
https://www.readbyqxmd.com/read/29139278/improving-pain-control-in-diabetic-neuropathy
#3
Peter Paisley, Mick Serpell
Diabetic neuropathy is thought to affect 1.9% of the world’s population and 50% of patients with a diagnosis of diabetes mellitus which would equate to 2.25 million people in the UK. The term diabetic neuropathy includes multiple distinct clinical entities that have been classified under the broad headings of focal and multifocal neuropathies and symmetrical neuropathies. Peripheral diabetic neuropathy, a chronic distal symmetrical predominantly sensory neuropathy, is the most common form of diabetic neuropathy...
March 2017: Practitioner
https://www.readbyqxmd.com/read/29135316/final-visual-outcomes-and-treatment-received-for-children-referred-from-a-uk-primary-school-visual-screening-program-a-comparison-of-an-orthoptic-led-program-with-orthoptic-delivered-services
#4
Tess Garretty
There is little published evidence relating to the final visual acuity of children who are identified as having reduced vision at a school screening program. The school vision screening program in Leeds (led by an orthoptist but delivered by health care support workers within the school nursing team) is examined. RESULTS: 7807 children were screened in school between November 1, 2013, and September 1, 2014. Of these, 319 (4%) failed the screen and were referred to the general optometry service and 547 (7%) were referred to the Children's Community Eye Service (CCES)...
November 14, 2017: Strabismus
https://www.readbyqxmd.com/read/29135245/unique-phase-transformation-from-graphene-to-carbide-on-re-0001-induced-by-strong-carbon-metal-interaction
#5
Yue Qi, Caixia Meng, Xiaozhi Xu, Bing Deng, Nannan Han, Jijun Zhao, Mengxi Liu, Qiang Fu, Min Hong, Yuanchang Li, Yanfeng Zhang, Zhongfan Liu, Yanxiao Ning, Kaihui Liu
During graphene growth on various transition metals in the periodic table, metal carbides always emerge to behave as complex intermediates. On VIII metals, metastable carbides usually evolve and then transform into graphene along the phase interfaces, and even no metal carbides can form on IB-IIB metals. In contrast, during graphene growth on groups IVB-VIB metals, carbides are usually generated even before the evolution of graphene and stably exist throughout the whole growth process. However, for the remaining transition metals, e...
November 14, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29131126/extending-the-neuroanatomic-territory-of-diffuse-midline-glioma-k27m-mutant-pineal-region-origin
#6
Andrea R Gilbert, Wafik Zaky, Murat Gokden, Christine E Fuller, Eylem Ocal, Norman E Leeds, Gregory N Fuller
Diffuse midline glioma, H3-K27M mutant (DMG-K27M) is a newly described, molecularly distinct infiltrative glioma that almost exclusively arises in midline CNS structures, including the brain stem, especially the pons, as well as the thalamus and spinal cord with rare examples seen in the cerebellum, third ventricle, and hypothalamus. To our knowledge, only 1 case of a molecularly confirmed DMG-K27M arising in the pineal region has been previously reported. We present the second occurrence of a tissue-confirmed DMG-K27M of the pineal region, which, to our knowledge, is the first case reported in a child and the first case with documented preoperative MRI...
November 4, 2017: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29124716/applying-cognitive-acuity-theory-to-the-development-and-scoring-of-situational-judgment-tests
#7
J Peter Leeds
The theory of cognitive acuity (TCA) treats the response options within items as signals to be detected and uses psychophysical methods to estimate the respondents' sensitivity to these signals. Such a framework offers new methods to construct and score situational judgment tests (SJT). Leeds (2012) defined cognitive acuity as the capacity to discern correctness and distinguish between correctness differences among simultaneously presented situation-specific response options. In this study, SJT response options were paired in order to offer the respondent a two-option choice...
November 9, 2017: Behavior Research Methods
https://www.readbyqxmd.com/read/29121284/neuropathic-pain-in-cancer-systematic-review-performance-of-screening-tools-and-analysis-of-symptom-profiles
#8
M R Mulvey, E G Boland, D Bouhassira, R Freynhagen, J Hardy, M J Hjermstad, S Mercadante, C Pérez, M I Bennett
Background: The objectives of this study were to evaluate the methodological quality of rigorous neuropathic pain assessment tools in applicable clinical studies, and determine the performance of screening tools for identifying neuropathic pain in patients with cancer. Methods: Systematic literature search identified studies reporting use of Leeds Assessment of Neuropathic Symptoms and Signs (LANSS), Douleur Neuropathique en 4 (DN4) or painDETECT (PDQ) in cancer patients with a clinical diagnosis of neuropathic or not neuropathic pain...
October 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29109734/similar-genetic-architecture-with-shared-and-unique-quantitative-trait-loci-for-bacterial-cold-water-disease-resistance-in-two-rainbow-trout-breeding-populations
#9
Roger L Vallejo, Sixin Liu, Guangtu Gao, Breno O Fragomeni, Alvaro G Hernandez, Timothy D Leeds, James E Parsons, Kyle E Martin, Jason P Evenhuis, Timothy J Welch, Gregory D Wiens, Yniv Palti
Bacterial cold water disease (BCWD) causes significant mortality and economic losses in salmonid aquaculture. In previous studies, we identified moderate-large effect quantitative trait loci (QTL) for BCWD resistance in rainbow trout (Oncorhynchus mykiss). However, the recent availability of a 57 K SNP array and a reference genome assembly have enabled us to conduct genome-wide association studies (GWAS) that overcome several experimental limitations from our previous work. In the current study, we conducted GWAS for BCWD resistance in two rainbow trout breeding populations using two genotyping platforms, the 57 K Affymetrix SNP array and restriction-associated DNA (RAD) sequencing...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/29072863/timeliness-of-receipt-of-early-childhood-vaccinations-among-children-of-immigrants-minnesota-2016
#10
Maureen Leeds, Miriam Halstead Muscoplat
Receiving recommended childhood vaccinations on schedule is the best way to prevent the occurrence and spread of vaccine-preventable diseases (1). Vaccination coverage among children aged 19-35 months in the United States exceeds 90% for most recommended vaccines in the early childhood series (2); however, previous studies have found that few children receive all recommended vaccine doses on time (3). The Minnesota Department of Health (MDH), using information from the Minnesota Immunization Information Connection (MIIC) and the MDH Office of Vital Records, examined early childhood immunization rates and found that children with at least one foreign-born parent were less likely to be up-to-date on recommended immunizations at ages 2, 6, 18, and 36 months than were children with two U...
October 27, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29063272/the-learning-curve-for-endoscopic-trans-sphenoidal-resection-of-pituitary-macroadenomas-a-single-institution-experience-leeds-uk
#11
James M W Robins, Seyed A Alavi, Atul K Tyagi, Paul A Nix, Tom M Wilson, Nick I Phillips
BACKGROUND: The object of this study was to assess whether increasing operative experience results in greater endoscopic trans-sphenoidal resection of pituitary macroadenomas and lower complications. METHODS: A retrospective single institution cohort study was performed. Subjects underwent endoscopic trans-sphenoidal resection of pituitary macroadenoma between July 2009 and July 2016 by three neurosurgeons. Following data collection, statistical analysis compared percentage of tumor resection and length of hospital stay (LOS) with experience...
October 23, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29058741/electronic-properties-of-single-layer-tungsten-disulfide-on-epitaxial-graphene-on-silicon-carbide
#12
Stiven Forti, Antonio Rossi, Holger Büch, Tommaso Cavallucci, Francesco Bisio, Alessandro Sala, Tevfik Onur Menteş, Andrea Locatelli, Michele Magnozzi, Maurizio Canepa, Kathrin Müller, Stefan Link, Ulrich Starke, Valentina Tozzini, Camilla Coletti
This work reports an electronic and micro-structural study of an appealing system for optoelectronics: tungsten disulfide (WS2) on epitaxial graphene (EG) on SiC(0001). The WS2 is grown via chemical vapor deposition (CVD) onto the EG. Low-energy electron diffraction (LEED) measurements assign the zero-degree orientation as the preferential azimuthal alignment for WS2/EG. The valence-band (VB) structure emerging from this alignment is investigated by means of photoelectron spectroscopy measurements, with both high space and energy resolution...
November 2, 2017: Nanoscale
https://www.readbyqxmd.com/read/29056825/central-poststroke-pain-its-profile-among-stroke-survivors-in-kano-nigeria
#13
Abdulbaki Halliru Bashir, Auwal Abdullahi, Muhammad Aliyu Abba, Naziru Bashir Mukhtar
BACKGROUND: Central poststroke pain (CPSP) caused by sensory dysfunction of central origin is a disabling condition that significantly affects the quality of life of stroke patients. AIM: The aim of this study is to determine the clinical profiles and pattern of CPSP among stroke patients in Kano, Nigeria. METHODS: The study was a cross-sectional design involving stroke survivors who were ≥18 years old and with no significant cognitive impairment approved by the Research Ethics Committee of Aminu Kano Teaching Hospital...
2017: Behavioural Neurology
https://www.readbyqxmd.com/read/29049963/optimization-of-physicochemical-properties-for-4-anilinoquinazoline-inhibitors-of-trypanosome-proliferation
#14
Jennifer L Woodring, Kelly A Bachovchin, Kimberly G Brady, Mitchell F Gallerstein, Jessey Erath, Scott Tanghe, Susan E Leed, Ana Rodriguez, Kojo Mensa-Wilmot, Richard J Sciotti, Michael P Pollastri
Human African trypanosomiasis (HAT) is a deadly disease in need of new chemotherapeutics that can cross into the central nervous system. We previously reported the discovery of 2 (NEU-617), a small molecule with activity against T. brucei bloodstream proliferation. Further optimization of 2 to improve the physicochemical properties (LogP, LLE, [1], and MPO score) [2] have led us to twelve sub-micromolar compounds, most importantly the headgroup variants 9i and 9j, and the linker variant 18. Although these 3 compounds had reduced potency compared to 2, they all had improved LogP, LLE and MPO scores...
December 1, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29048698/soft-tissue-reinforcement-with-a-leeds-keio-artificial-ligament-in-revision-surgery-for-dislocated-total-hip-arthroplasty
#15
Shigeo Aota, Shin-Ichi Kikuchi, Hironori Ohashi, Naoko Kitano, Michiyuki Hakozaki, Shin-Ichi Konno
INTRODUCTION: Since dislocation after total hip arthroplasty (THA) greatly diminishes patient's quality of life, the THA frequently needs revision. However, it is common for the dislocation not to heal even after reconstruction, but rather to become intractable. METHODS: The 17 patients with dislocated THA, mean age of 71 years (range 51-87 years), who underwent a revision THA together with soft tissue reinforcement with a Leeds-Keio (LK) ligament were enrolled...
October 16, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29034804/cip2a-expression-predicts-recurrences-of-tamoxifen-treated-breast-cancer
#16
Shawn Baldacchino, Laura M Wastall, Christian Saliba, Thomas A Hughes, Christian Scerri, Angelene Berwick, Valerie Speirs, Andrew M Hanby, Godfrey Grech
CIP2A is emerging as an oncoprotein overexpressed commonly across many tumours and generally correlated with higher tumour grade and therapeutic resistance. CIP2A drives an oncogenic potential through inhibiting protein phosphatase 2A, stabilizing MYC, and promoting epithelial-to-mesenchymal transition, although further biological mechanisms for CIP2A are yet to be defined. CIP2A protein expression was studied by immunohistochemistry in oestrogen receptor-positive primary breast cancers (n = 250) obtained from the Leeds Tissue Bank...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29021600/diagnosing-antimicrobial-resistance
#17
REVIEW
Carey-Ann D Burnham, Jennifer Leeds, Patrice Nordmann, Justin O'Grady, Jean Patel
Antimicrobial resistance constitutes a global burden and is one of the major threats to public health. Although the emergence of resistant microorganisms is a natural phenomenon, the overuse or inappropriate use of antimicrobials has had a great effect on resistance evolution. Rapid diagnostic tests that identify drug-resistant bacteria, determine antimicrobial susceptibility and distinguish viral from bacterial infections can guide effective treatment strategies. Moreover, rapid diagnostic tests could facilitate epidemiological surveillance, as emerging resistant infectious agents and transmission can be monitored...
October 12, 2017: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/28990836/images-from-the-dental-illustration-unit-at-leeds-teaching-hospitals-nhs-trust
#18
Tim Zoltie, Zoe Kakiziba, Colin Sullivan, Tom Archer, Chris Hughes
No abstract text is available yet for this article.
October 9, 2017: Journal of Visual Communication in Medicine
https://www.readbyqxmd.com/read/28986275/quantification-of-resident-work-in-colorectal-surgery
#19
Elizabeth A Bailey, Adam P Johnson, Ira L Leeds, Rachel L Medbery, Vanita Ahuja, Thomas VanderMeer, Elizabeth C Wick, Busayo Irojah, Rachel R Kelz
OBJECTIVE: To examine resident intraoperative participation, perceived autonomy, and communication patterns between residents and attending surgeons using a novel survey tool. DESIGN: This was a prospective multi-institutional study. Operative residents completed the survey tool immediately after each colorectal resection performed during the study period. Resident intraoperative participation was quantified including degree of involvement in the technical aspects of the case, self-perception of autonomy, and communication strategies between the resident and attending...
October 3, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28985313/general-practitioners-perceptions-of-irritable-bowel-syndrome-a-q-methodological-study
#20
Stephen Bradley, Sarah Alderson, Alexander C Ford, Robbie Foy
Background: Irritable bowel syndrome (IBS) is a common disorder that imposes a significant burden upon societies, health care and quality of life, worldwide. While a diverse range of patient viewpoints on IBS have been explored, the opinions of the GPs they ideally need to develop therapeutic partnerships with are less well defined. Objective: To explore how GPs perceive IBS, using Q-methodology, which allows quantitative interpretation of qualitative data. Design and Setting: A Q-methodological study of GPs in Leeds, UK...
July 14, 2017: Family Practice
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