keyword
https://read.qxmd.com/read/38523273/ecological-patterns-and-processes-of-temporal-turnover-within-lung-infection-microbiota
#1
JOURNAL ARTICLE
Helen Gavillet, Lauren Hatfield, Andrew Jones, Anirban Maitra, Alexander Horsley, Damian Rivett, Christopher van der Gast
BACKGROUND: Chronic infection and consequent airway inflammation are the leading causes of morbidity and early mortality for people living with cystic fibrosis (CF). However, lower airway infections across a range of chronic respiratory diseases, including in CF, do not follow classical 'one microbe, one disease' concepts of infection pathogenesis. Instead, they are comprised of diverse and temporally dynamic lung infection microbiota. Consequently, temporal dynamics need to be considered when attempting to associate lung microbiota with changes in disease status...
March 25, 2024: Microbiome
https://read.qxmd.com/read/38517652/efficacy-and-safety-of-tofacitinib-for-chronic-plaque-psoriasis-and-psoriatic-arthritis-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#2
JOURNAL ARTICLE
Qianqian Dai, Yanfeng Zhang, Qian Liu, Chijin Zhang
OBJECTIVES: To summarize and analyze the results of published randomized controlled trials of tofacitinib for the treatment of chronic plaque psoriasis and psoriatic arthritis(PsA) and discuss its efficacy and safety. PATIENTS AND METHODS: An exhaustive systematic search encompassing PubMed, Cochrane, Embase, and Web of Science databases was conducted up to July 2023. Studies eligible for inclusion were analyzed, organized using Review Manager version 5.4.1 (Cochrane Collaboration, Oxford, UK) and STATA 15...
March 22, 2024: Clinical Rheumatology
https://read.qxmd.com/read/38512507/the-use-of-poly-4-hydroxybutyrate-p4hb-phasix%C3%A2-mesh-in-ventral-hernia-repair-a-systematic-review-and-meta-analysis
#3
REVIEW
Daniel H Tran, Charles Rubarth, Steven G Leeds, Luke Fair, Titus McGowan, Sudha Ramakrishnan, Rehma Shabbir, Gerald Ogola, Marc A Ward, Bola Aladegbami
PURPOSE/BACKGROUND: Despite the growing use of bioabsorbable mesh in ventral hernia repairs (VHR), the evidence of its impact on patient outcomes remains limited. This study aims to investigate the efficacy and safety profile of poly-4-hydroxybutyrate (P4HB) mesh for ventral hernia repair through a systematic review and meta-analysis. METHODS: A literature search of five databases (PubMed, Embase, Ovid, Medline, and Google Scholar) produced a list of publications that analyzed the use of P4HB mesh in ventral hernia repair in both clean and contaminated cases...
March 21, 2024: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://read.qxmd.com/read/38507174/achieving-fascial-closure-with-preoperative-botulinum-toxin-injections-in-abdominal-wall-reconstruction-outcomes-from-a-high-volume-center
#4
JOURNAL ARTICLE
Lucas Fair, Steven G Leeds, Syed Harris Bokhari, Simon Esteva, Tanner Mathews, Gerald O Ogola, Marc A Ward, Bola Aladegbami
Preoperative injection of Botulinum Toxin A (Botox) has been described as an adjunctive therapy to facilitate fascial closure of large hernia defects in abdominal wall reconstruction (AWR). The purpose of this study was to evaluate the impact of Botox injections on fascial closure and overall outcomes to further validate its role in AWR. A prospectively maintained database was retrospectively reviewed to identify all patients undergoing AWR at our institution between January 2014 and March 2022. Patients who did and did not receive preoperative Botox injections were analyzed and compared...
March 20, 2024: Updates in Surgery
https://read.qxmd.com/read/38506037/impact-of-green-hospital-design-on-patients-well-being-and-operating-cost-of-the-hospital-a-systematic-review
#5
JOURNAL ARTICLE
Ruchir Sharda, Prerana Dongre, Harini Srinivasan, Laxmi Kumari, Meenal Kulkarni
Hospitals play a crucial role in providing medical care to patients, but they also have a significant environmental impact due to their high energy consumption and resource use. In recent years, there has been growing interest in the concept of green hospital design, which aims to reduce the environmental footprint of hospitals while simultaneously improving patient outcomes.10 articles were finalized for review and were coded in QDA Miner qualitative analysis software for descriptive and link analysis. Results indicated a strong correlation between green design aspects of hospital and patient well-being, it failed to provide any evidence of concrete relation between relation between green hospital design and lower operation cost...
March 20, 2024: Hospital Topics
https://read.qxmd.com/read/38495958/innovation-in-sport-medicine-and-science-a-global-social-network-analysis-of-stakeholder-collaboration-in-rugby-union
#6
JOURNAL ARTICLE
Natalie R Erskine, Sharief Hendricks, Ben Jones, Faatiema Salie
OBJECTIVES: To investigate the network of stakeholders involved in rugby union research across the globe. METHODS: Using author affiliations listed on scientific publications, we identified the organisations that contributed to rugby union research from 1977 to 2022 and examine collaboration through coauthorship indicators. We determined the locations and sectors of identified organisations and constructed a collaboration network. Network metrics, including degree centrality and betweenness centrality, are computed to identify influential organisations and measure intersector collaboration...
2024: BMJ Open Sport & Exercise Medicine
https://read.qxmd.com/read/38494317/are-we-missing-pancreatic-exocrine-insufficiency-in-at-risk-groups-prospective-assessment-of-the-current-practice-and-yield-of-faecal-elastase-testing-in-patients-with-diabetes-mellitus-hiv-and-or-high-alcohol-intake
#7
JOURNAL ARTICLE
Mustafa Jalal, John S Leeds, Hey-Long Ching, Andrei Oprescu, Ann Tunbridge, Julia Greig, Solomon Tesfaye, Andrew D Hopper
There is cumulative evidence that pancreatic exocrine insufficiency (PEI) is under-recognised and can occur in patients with 'at-risk' conditions. Thus, we aimed to assess the current practice and yield of requesting faecal elastase (FEL-1), an indicator of PEI, in patients with 'at-risk' conditions. We prospectively recruited patients attending secondary care clinics with diabetes mellitus (DM), people living with HIV (PLHIV) and inpatients admitted to hospital with high alcohol intake (HAI). All patients underwent testing with FEL-1...
November 2023: Clinical Medicine: Journal of the Royal College of Physicians of London
https://read.qxmd.com/read/38485654/emotion-regulation-and-psychological-dependence-on-pain-medication-among-hospital-outpatients-with-chronic-spinal-pain-the-influence-of-rumination-about-pain-and-alexithymia
#8
JOURNAL ARTICLE
Romaana Kapadi, James Elander, Antony H Bateman
Objective : To examine the extent to which pain acceptance, pain catastrophising and alexithymia moderate associations between pain intensity and psychological pain medication dependence. Methods : Participants (106 hospital outpatients with chronic spinal pain) completed the Leeds Dependence Questionnaire (LDQ) to measure psychological dependence on pain medication, and the Chronic Pain Acceptance Questionnaire-8 (CPAQ-8), the Pain Catastrophising Scale (PCS) and the Toronto Alexithymia Scale-20 (TAS-20), plus the Depression, Anxiety and Stress Scale-21 (DASS-21)...
March 14, 2024: Substance Use & Misuse
https://read.qxmd.com/read/38483366/five-year-longitudinal-follow-up-of-restorative-neurostimulation-shows-durability-of-effectiveness-in-patients-with-refractory-chronic-low-back-pain-associated-with-multifidus-muscle-dysfunction
#9
JOURNAL ARTICLE
Christopher Gilligan, Willem Volschenk, Marc Russo, Matthew Green, Christopher Gilmore, Vivek Mehta, Kristiaan Deckers, Kris De Smedt, Usman Latif, Dawood Sayed, Peter Georgius, Jonathan Gentile, Bruce Mitchell, Meredith Langhorst, Frank Huygen, Ganesan Baranidharan, Vikas Patel, Eugene Mironer, Edgar Ross, Alexios Carayannopoulos, Salim Hayek, Ashish Gulve, Jean-Pierre Van Buyten, Antoine Tohmeh, Jeffrey Fischgrund, Shivanand Lad, Farshad Ahadian, Timothy Deer, William Klemme, Richard Rauck, James Rathmell, Greg Maislin, Jan Pieter Heemels, Sam Eldabe
BACKGROUND: Adults with refractory, mechanical chronic low back pain associated with impaired neuromuscular control of the lumbar multifidus muscle have few treatment options that provide long-term clinical benefit. This study hypothesized that restorative neurostimulation, a rehabilitative treatment that activates the lumbar multifidus muscles to overcome underlying dysfunction, is safe and provides relevant and durable clinical benefit to patients with this specific etiology. MATERIALS AND METHODS: In this prospective five-year longitudinal follow-up of the ReActiv8-B pivotal trial, participants (N = 204) had activity-limiting, moderate-to-severe, refractory, mechanical chronic low back pain, a positive prone instability test result indicating impaired multifidus muscle control, and no indications for spine surgery...
March 11, 2024: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/38477675/low-dose-morphine-does-not-cause-sleepiness-in-copd-a-secondary-analysis-of-a-randomized-trial
#10
JOURNAL ARTICLE
Thomas J Altree, Barbara Toson, Kelly A Loffler, Magnus Ekström, David C Currow, Danny J Eckert
RATIONALE: Regular, low-dose, sustained-release morphine is frequently prescribed for persistent breathlessness in chronic obstructive pulmonary disease (COPD). However, effects on daytime sleepiness, perceived sleep quality and daytime function have not been rigorously investigated. OBJECTIVES: Determine the effects of regular, low-dose, sustained-release morphine on sleep parameters in COPD. METHODS: Pre-specified secondary analyses of validated sleep questionnaire data from a randomized trial of daily, low-dose, sustained -release morphine versus placebo over four weeks commencing at 8mg or 16mg/day with blinded up-titration over two weeks to a maximum of 32mg/day...
March 13, 2024: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38472528/association-between-enthesitis-dactylitis-resolution-and-patient-reported-outcomes-in-guselkumab-treated-patients-with-psoriatic-arthritis
#11
JOURNAL ARTICLE
Proton Rahman, Iain B McInnes, Atul Deodhar, Georg Schett, Phillip J Mease, May Shawi, Daniel J Cua, Jonathan P Sherlock, Alexa P Kollmeier, Xie L Xu, Shihong Sheng, Christopher T Ritchlin, Dennis McGonagle
OBJECTIVES: To evaluate the association between enthesitis resolution (ER) and dactylitis resolution (DR) and meaningful improvements in patient-reported outcomes (PROs) among biologic-naïve patients with PsA receiving guselkumab in the DISCOVER-2 study. METHODS: Enthesitis and dactylitis, characteristic lesions of PsA, were evaluated by independent assessors using the Leeds Enthesitis Index (range, 0-6) and Dactylitis Severity Score (range, 0-60). Proportions of patients with ER or DR (score = 0) among those with score > 0 at baseline were determined at weeks 24, 52, and 100...
March 12, 2024: Clinical Rheumatology
https://read.qxmd.com/read/38460549/characteristics-associated-with-patient-reported-treatment-success-in-psoriatic-arthritis
#12
JOURNAL ARTICLE
Christeen Samuel, Amanda Finney, Thomas Grader-Beck, Uzma Haque, John Miller, Suzanne M Grieb, Laura Prichett, Ana-Maria Orbai
OBJECTIVES: To determine characteristics associated with patient-reported treatment success in psoriatic arthritis (PsA). METHODS: Rheumatologist-diagnosed PsA patients fulfilling the CASPAR classification were recruited from a single center. PsA outcome measures included: 66/68 swollen/tender joint counts, Leeds/SPARCC dactylitis/enthesitis indices, psoriasis body surface area (BSA), and patient-reported outcomes (PROs) including PROMIS. The primary outcome was a patient-reported item: "Today, considering the level of control of your psoriatic arthritis and psoriasis, do you consider your treatment has been successful?" Descriptive and multivariate logistic regression analyses identified clinical predictors of patient-reported treatment success...
March 9, 2024: Rheumatology
https://read.qxmd.com/read/38446398/assessment-of-patient-physician-interactions-in-psoriatic-arthritis-national-results-of-the-assist-study
#13
JOURNAL ARTICLE
Fabio Massimo Perrotta, Rossana Scrivo, Salvatore D'Angelo, Silvia Scriffignano, Andrea Delle Sedie, Laura Coates, Ennio Lubrano
INTRODUCTION: An overarching principle for the management of psoriatic arthritis (PsA) is a shared decision-making process between physicians and patients. The aim of this study is to assess the patient-physician relationship in a group of patients with PsA, by using the Perceived Efficacy in Patient-Physician Interactions (PEPPI) and CollaboRATE instruments. METHODS: This is a cross-sectional multicenter study where consecutive patients with PsA were enrolled. For each patient, the main demographic, comorbid conditions, and clinical data were collected, including the assessment of disease activity, function, quality of life, and impact of disease...
March 6, 2024: Rheumatology and Therapy
https://read.qxmd.com/read/38435412/real-world-experience-of-il-17ai-drug-survival-in-a-large-cohort-of-axial-spondyloarthritis-and-psoriatic-arthritis
#14
JOURNAL ARTICLE
Jake Weddell, Naw Ra Aung Din, Stephanie R Harrison, Xabier Michelena, Dennis McGonagle, Andrew Barr, Claire Vandevelde, Jane Freeston, Helena Marzo-Ortega
OBJECTIVE: The aim was to assess the use and drug survival of IL-17Ai in a real-world cohort of axial SpA (axSpA) and PsA patients. METHODS: Patients ever commenced on an IL-17Ai (secukinumab or ixekizumab) for axSpA or PsA at the Leeds Specialist Spondyloarthritis Service were identified. Demographics, IL-17Ai treatment length and reason for cessation were collected. Drug survival data were plotted as a Kaplan-Meier curve, with log rank test of median survival compared between axSpA and PsA...
2024: Rheumatology Advances in Practice
https://read.qxmd.com/read/38433860/when-leuprolide-acetate-is-essential-to-care-a%C3%A2-review-of-the-literature-and-framework-for-assessing-drug-allergy
#15
Ami P Belmont, Joseph Rosano, June Criscione, Cosby A Stone, Stephanie Leeds
Gonadotropin-releasing hormone agonists are uncommonly associated with hypersensitivity reactions. To date, there have been few reports of these cases by allergists and no clear published protocols on testing. Here, we report the case of a patient who had a potential reaction to leuprolide acetate depot and a framework for assessing for drug hypersensitivity with the available literature in mind.
May 2024: J Allergy Clin Immunol Glob
https://read.qxmd.com/read/38432713/chronic-and-postprandial-effect-of-blueberries-on-cognitive-function-alertness-and-mood-in-participants-with-metabolic-syndrome-results-from-a-six-month-double-blind-randomized-controlled-trial
#16
JOURNAL ARTICLE
Peter J Curtis, Vera van der Velpen, Lindsey Berends, Amy Jennings, Laura Haag, Anne-Marie Minihane, Preeti Chandra, Colin D Kay, Eric B Rimm, Aedín Cassidy
BACKGROUND: Anthocyanin and blueberry intakes positively associated with cognitive function in population-based studies and cognitive benefits in randomized controlled trials of adults with self-perceived or clinical cognitive dysfunction. To date, adults with metabolic syndrome (MetS) but without cognitive dysfunction are understudied. OBJECTIVES: Cognitive function, mood, alertness, and sleep quality were assessed as secondary end points in MetS participants, postprandially (>24 h) and following 6-mo blueberry intake...
March 2024: American Journal of Clinical Nutrition
https://read.qxmd.com/read/38423028/a-preoperative-package-of-care-for-osteoarthritis-consisting-of-weight-loss-orthotics-rehabilitation-and-topical-and-oral-analgesia-opportunity-a-two-centre-open-label-randomised-controlled-feasibility-trial
#17
JOURNAL ARTICLE
A Hamish R W Simpson, Nicholas D Clement, Sharon A Simpson, Hemandt Pandit, Susie Smillie, Anthony R Leeds, Philip G Conaghan, Sarah R Kingsbury, David Hamilton, Peter Craig, David Ray, Catriona Keerie, Elaine Kinsella, Anna Bell-Higgs, Arlene McGarty, Christine Beadle, Colin R Howie, John Norrie
BACKGROUND: Osteoarthritis of the knee is a major cause of disability worldwide. Non-operative treatments can reduce the morbidity but adherence is poor. We hypothesised that adherence could be optimised if behavioural change was established in the preoperative period. Therefore, we aimed to assess feasibility, acceptability, and recruitment and retention rates of a preoperative package of non-operative care in patients awaiting knee replacement surgery. METHODS: We did an open-label, randomised controlled, feasibility trial in two secondary care centres in the UK...
February 26, 2024: Lancet Rheumatology
https://read.qxmd.com/read/38420962/the-implications-of-competing-risks-and-direct-treatment-disutility-in-cardiovascular-disease-and-osteoporotic-fracture-risk-prediction-and-cost-effectiveness-analysis
#18
JOURNAL ARTICLE
Bruce Guthrie, Gabriel Rogers, Shona Livingstone, Daniel R Morales, Peter Donnan, Sarah Davis, Ji Hee Youn, Rob Hainsworth, Alexander Thompson, Katherine Payne
BACKGROUND: Clinical guidelines commonly recommend preventative treatments for people above a risk threshold. Therefore, decision-makers must have faith in risk prediction tools and model-based cost-effectiveness analyses for people at different levels of risk. Two problems that arise are inadequate handling of competing risks of death and failing to account for direct treatment disutility (i.e. the hassle of taking treatments). We explored these issues using two case studies: primary prevention of cardiovascular disease using statins and osteoporotic fracture using bisphosphonates...
February 2024: Health Soc Care Deliv Res
https://read.qxmd.com/read/38418688/prevalence-and-predictors-of-postcholecystectomy-syndrome-in-nepalese-patients-after-1%C3%A2-week-of-laparoscopic-cholecystectomy-a-cross-sectional-study
#19
JOURNAL ARTICLE
Roshani Shrestha, Prangtip Chayaput, Kessiri Wongkongkam, Wallada Chanruangvanich
Postcholecystectomy syndrome (PCS) is persistent distressing symptoms which develops following a laparoscopic cholecystectomy (LC); in cases when the condition is severe, readmission may be necessary. However, research on the prevalence of PCS and potential factors associated with PCS in Nepalese patients is still limited. An observational point-prevalence, correlational predictive cross-sectional study was conducted to determine the prevalence of PCS and examine what predicting factors including preoperative anxiety, preoperative dyspepsia, smoking, alcohol consumption, and duration of preoperative symptoms are associated with PCS...
February 28, 2024: Scientific Reports
https://read.qxmd.com/read/38417872/a-case-of-peripheral-t-cell-lymphoma-in-which-therapy-related-myelodysplastic-syndrome-developed-and-a-second-autologous-transplantation-was-performed
#20
JOURNAL ARTICLE
Shun-Ichiro Nakagawa, Yuki Nukii, Kanako Mochizuki, Akio Uchiyama, Yoshinobu Maeda, Toshiro Kurokawa
We report a case of therapy-related myelodysplastic syndrome (MDS), which developed 9 years after autologous peripheral blood stem cell transplantation (PBSCT) for peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS). A 65-year-old male was diagnosed with PTCL-NOS. After 6 cycles of the CHOP (cyclophosphamide [CPA], doxorubicin, vincristine, and prednisone) regimen, he achieved a first complete response (CR). He relapsed 33 months later and received salvage chemotherapy, which consisted of the CHASE regimen (CPA, high-dose cytarabine, dexamethasone, and etoposide)...
February 28, 2024: Journal of Clinical and Experimental Hematopathology: JCEH
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