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https://www.readbyqxmd.com/read/29351751/social-determinants-of-male-health-a-case-study-of-leeds-uk
#1
Alan White, Amanda Seims, Ian Cameron, Tim Taylor
BACKGROUND: The social determinants of health have a disproportionate impact on mortality in men. A study into the state of health of the male population in Leeds was undertaken to guide public health commissioning decisions. This paper reports on the data relating to the social lives of men. METHODS: A cross-sectional study was undertaken, comprising descriptive analysis of data relating to educational attainment, housing, employment (including benefit claimants), marital status and relationships...
January 19, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29328803/parent-pagers-improving-patient-experience-and-efficiency-in-paediatric-pacu
#2
Gogs Byrn
A quality improvement initiative undertaken by the paediatric recovery team at the Leeds Children's Hospital sought to improve patient experience and efficiency by implementing an electronic pager system to contact parents/carers following their child's surgery.
May 2017: Journal of Perioperative Practice
https://www.readbyqxmd.com/read/29316991/is-dietary-macronutrient-composition-during-pregnancy-associated-with-offspring-birth-weight-an-observational-study
#3
Sukshma S Sharma, Darren C Greenwood, Nigel A B Simpson, Janet E Cade
There is lack of evidence on the differential impact of maternal macronutrient consumption: carbohydrates (CHO), fats and protein on birth weight. We investigated the association between maternal dietary macronutrient intakes and their sub-components such as saccharides and fatty acids and birth weight. This analyses included 1,196 women with singleton pregnancies who were part of the CAffeine and REproductive health study in Leeds, UK between 2003 and 2006. Women were interviewed in each trimester. Dietary information was collected twice using a 24-h dietary recall about 8-12 weeks and 13-27 weeks of gestation...
January 10, 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29314866/spearmint-extract-improves-working-memory-in-men-and-women-with-age-associated-memory-impairment
#4
Kelli A Herrlinger, Kristin M Nieman, Kristen D Sanoshy, Brenda A Fonseca, Joanne A Lasrado, Arianne L Schild, Kevin C Maki, Keith A Wesnes, Michael A Ceddia
OBJECTIVE: The purpose of this study was to investigate the effects of supplementation with a spearmint (Mentha spicata L.) extract, high in polyphenols including rosmarinic acid, on cognitive performance, sleep, and mood in individuals with age-associated memory impairment (AAMI). DESIGN: Subjects with AAMI (N = 90; 67% female; age = 59.4 ± 0.6 years) were randomly assigned (n = 30/group) to consume 900, 600, or 0 mg/day (two capsules, once daily) spearmint extract for 90 days, in this double-blind, placebo-controlled trial...
January 9, 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/29307004/understanding-pseudomonas-status-among-adults-with-cystic-fibrosis-a-real-world-comparison-of-the-leeds-criteria-against-clinicians-decision
#5
Zhe Hui Hoo, Frank Peter Edenborough, Rachael Curley, Laura Prtak, Jane Dewar, Mark Ivan Allenby, Julia Anne Nightingale, Martin James Wildman
Pseudomonas aeruginosa status influences cystic fibrosis (CF) clinical management but no 'gold standard' definition exists. The Leeds criteria are commonly used but may lack sensitivity for chronic P. aeruginosa. We compared clinicians' decision with the Leeds criteria in three adult CF centres. Two independent prospective datasets (Sheffield dataset, n = 185 adults; ACtiF pilot dataset, n = 62 adults from two different centres) were analysed. Clinicians involved in deciding P. aeruginosa status were blinded to the study objectives...
January 6, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29302829/effectiveness-and-safety-of-ustekinumab-in-na%C3%A3-ve-or-tnf-inhibitors-failure-psoriatic-arthritis-patients-a-24-month-prospective-multicentric-study
#6
Maria Sole Chimenti, Augusta Ortolan, Mariagrazia Lorenzin, Paola Triggianese, Marina Talamonti, Luisa Costa, Francesco Caso, Marta Favero, Miriam Teoli, Marco Galluzzo, Raffaele Scarpa, Leonardo Punzi, Roberto Perricone, Roberta Ramonda
The current prospective observational study aimed to evaluate the long-term (24 months), real-life effectiveness of ustekinumab in psoriatic arthritis (PsA). Consecutive patients with moderate-severe PsA and active psoriasis who begun ustekinumab treatment were evaluated prospectively (January 2015-March 2017). Clinimetric scores and biochemical values were assessed at baseline (T0), at 6 (T6), 12 (T12), and 24 (T24) months. Friedman test and generalized linear models were used to compare variables over time...
January 4, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29301082/optimization-of-physicochemical-properties-for-4-anilinoquinoline-inhibitors-of-plasmodium-falciparum-proliferation
#7
Naimee Mehta, Lori Ferrins, Susan E Leed, Richard J Sciotti, Michael P Pollastri
We recently reported the medicinal chemistry re-optimization of a known human tyrosine kinase inhibitor, lapatinib, against a variety of parasites responsible for numerous tropical diseases, including: human African trypanosomiasis (Trypanosoma brucei), Chagas disease (T. cruzi), Leishmaniasis (Leishmania spp.) and malaria (Plasmodium falciparum). Herein, we report our continuing efforts to optimize this series against P. falciparum. Through the design of a library of compounds focused on reducing the lipophilicity and molecular weight, followed by an SAR exploration, we have identified NEU-1953 (40)...
January 4, 2018: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29296829/safety-pharmacokinetics-and-reversal-of-apixaban-anticoagulation-with-andexanet-alfa
#8
Deborah Siegal, Genmin Lu, Janet M Leeds, Mark Karbarz, Janice Castillo, Vandana Mathur, Athiwat Hutchaleelaha, Uma Sinha, Michael Kitt, Matt McClure, Stanley J Hollenbach, John T Curnutte, Pamela B Conley, Mark Crowther
Direct factor Xa (FXa) inhibitors lack a specific reversal agent for emergencies such as major bleeding or urgent surgery. Andexanet alfa, a modified, catalytically inactive, recombinant human FXa derivative, reverses anticoagulant effect by binding and sequestering FXa inhibitors. This original report of safety and dose-finding, phase 1 and 2 randomized, double-blind, placebo-controlled studies, investigated various doses of andexanet in healthy volunteers. Phase 1 evaluated the safety and pharmacokinetics of andexanet (n = 24) or placebo (n = 8)...
September 26, 2017: Blood Advances
https://www.readbyqxmd.com/read/29289554/efficacy-and-safety-of-on-demand-use-of-2-treatments-designed-for-different-etiologies-of-female-sexual-interest-arousal-disorder-3-randomized-clinical-trials
#9
Adriaan Tuiten, Kim van Rooij, Jos Bloemers, Christoph Eisenegger, Jack van Honk, Rob Kessels, Sheryl Kingsberg, Leonard R Derogatis, Leo de Leede, Jeroen Gerritsen, Hans P F Koppeschaar, Berend Olivier, Walter Everaerd, Henderik W Frijlink, Daniël Höhle, Robert P J de Lange, Koen B E Böcker, James G Pfaus
BACKGROUND: In women, low sexual desire and/or sexual arousal can lead to sexual dissatisfaction and emotional distress, collectively defined as female sexual interest/arousal disorder (FSIAD). Few pharmaceutical treatment options are currently available. AIM: To investigate the efficacy and safety of 2 novel on-demand pharmacologic treatments that have been designed to treat 2 FSIAD subgroups (women with low sensitivity for sexual cues and women with dysfunctional over-activation of sexual inhibition) using a personalized medicine approach using an allocation formula based on genetic, hormonal, and psychological variables developed to predict drug efficacy in the subgroups...
December 27, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29282037/a-novel-integrative-procedure-for-identifying-and-integrating-three-dimensions-of-objectively-measured-free-living-sedentary-behaviour
#10
Anna Myers, Catherine Gibbons, Edward Butler, Michelle Dalton, Nicola Buckland, John Blundell, Graham Finlayson
BACKGROUND: The widely accepted definition of sedentary behaviour [SB] refers to any waking behaviour characterized by an energy expenditure ≤1.5 metabolic equivalents [METs] while in a sitting or reclining posture. At present, there is no single field-based device which objectively measures sleep, posture and activity intensity simultaneously. The aim of this study was to develop a novel integrative procedure [INT] to combine information from two validated activity monitors on sleep, activity intensity and posture, the three key dimensions of SB...
December 28, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29281065/usefulness-of-sealants-for-dural-closure-evaluation-in-an-in-vitro-model
#11
Tristan van Doormaal, Ahmet Kinaci, Sander van Thoor, Saskia Redegeld, Wilhelmina Bergmann, Albert van der Zwan
BACKGROUND: Cerebrospinal fluid (CSF) leakage occurs in 4% to 32% of cranial surgeries and is associated with significant patient burden and expense. The use of sealant as an adjunct to primary dural closure is assumed to help prevent CSF leakage. OBJECTIVE: To examine the utility of different sealants for dural closure using an in Vitro model. METHODS: We evaluated 9 commonly used dural sealants, including Tachosil (Takeda Inc, Osaka, Japan), Adherus (Hyperbranch Inc, Durham, North Carolina), Duraform (Codman, Raynham, Massachusetts), Tissudura (Baxter, Deerfield, Illinois), Hemopatch (Baxter), TissuePatchDural (Tissuemed, Leeds, United Kingdom), Tisseel (Baxter), Duragen Secure (Integra, Plainsboro, New Jersey), and Duraseal, (Integra)...
December 21, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29237062/rumpel-leede-phenomenon-associated-with-blood-flow-restriction-training
#12
Takeshi Kondo
No abstract text is available yet for this article.
December 11, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29226548/diffusion-tensor-imaging-determines-three-dimensional-architecture-of-human-cervix-a-cross-sectional-study
#13
J P Nott, E Pervolaraki, A P Benson, E A Bonney, J D Pickering, N Wilkinson, Nab Simpson
OBJECTIVE: To determine the microarchitecture of the cervix using high-resolution diffusion tensor (DT) magnetic resonance imaging (MRI). DESIGN: Cross-sectional study. SETTING: Leeds, UK. SAMPLE: Women undergoing hysterectomy for benign pathology. METHODS: Ex-vivo DT-MRI measurements were obtained using a 9.4-T Bruker nuclear magnetic resonance (NMR) spectrometer on seven fixed human cervices obtained at hysterectomy...
October 26, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29210981/health-co-benefits-of-green-building-design-strategies-and-community-resilience-to-urban-flooding-a-systematic-review-of-the-evidence
#14
REVIEW
Adele Houghton, Carlos Castillo-Salgado
Climate change is increasingly exacerbating existing population health hazards, as well as resulting in new negative health effects. Flooding is one particularly deadly example of its amplifying and expanding effect on public health. This systematic review considered evidence linking green building strategies in the Leadership in Energy and Environmental Design® (LEED) Rating System with the potential to reduce negative health outcomes following exposure to urban flooding events. Queries evaluated links between LEED credit requirements and risk of exposure to urban flooding, environmental determinants of health, co-benefits to public health outcomes, and co-benefits to built environment outcomes...
December 6, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29202002/a-comparison-of-outcomes-between-a-lumen-apposing-metal-stent-with-electrocautery-enhanced-delivery-system-and-a-bi-flanged-metal-stent-for-drainage-of-walled-off-pancreatic-necrosis
#15
Noor L H Bekkali, Manu K Nayar, John S Leeds, Richard M Charnley, Matthew T Huggett, Kofi W Oppong
Background and study aims:  Bi-flanged metal stents (BFMS) have shown promise in the drainage of walled-off pancreatic necrosis (WON), but their placement requires multiple steps and the use of other devices. More recently, a novel device consisting of a combined lumen-apposing metal stent (LAMS) and electrocautery-enhanced delivery system has been introduced. The aim of this study was to compare the placement and outcomes of the two devices. Patients and methods:  This was a retrospective review of consecutive patients undergoing endoscopic ultrasound-guided placement of BFMS or LAMS for drainage of symptomatic WON...
December 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/29194095/is-nonmetastatic-cutaneous-melanoma-predictable-through-genomic-biomarkers
#16
Mattia Branca, Samuel Orso, Roberto C Molinari, Haotian Xu, Stéphane Guerrier, Yuming Zhang, Nabil Mili
Cutaneous melanoma is a highly aggressive skin cancer whose treatment and prognosis are critically affected by the presence of metastasis. In this study, we address the following issue: which gene transcripts and what kind of interactions between them can allow to predict nonmetastatic from metastatic melanomas with a high level of accuracy? We carry out a meta-analysis on the first gene expression set of the Leeds melanoma cohort, as made available online on 11 May 2016 through the ArrayExpress platform with MicroArray Gene Expression number 4725...
February 2018: Melanoma Research
https://www.readbyqxmd.com/read/29178495/novel-device-based-acne-treatments-comparison-of-a-1450-nm-diode-laser-and-microneedling-radiofrequency-on-mild-to-moderate-acne-vulgaris-and-seborrhoea-in-korean-patients-through-a-20-week-prospective-randomized-split-face-study
#17
H H Kwon, H Y Park, S C Choi, Y Bae, J Y Jung, G-H Park
BACKGROUND: While device-based acne treatments are widely applied for patients not tolerating conventional medications, related controlled studies have been still limited. Recently, non-ablative 1450-nm diode laser (DL) and fractional microneedling radiofrequency (FMR) have been effectively used for acne, in addition to well-recognized dermal remodelling effects. OBJECTIVE: To compare the clinical course of acne treatment between DL and FMR. METHODS: Twenty-five Korean patients with mild-to-moderate facial acne completed treatments with DL and FMR through a 20-week, randomized split-face study...
November 24, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29160630/synthetic-grafts-in-the-treatment-of-ruptured-anterior-cruciate-ligament-of-the-knee-joint
#18
REVIEW
Wojciech Satora, Aleksandra Królikowska, Andrzej Czamara, Paweł Reichert
The anterior cruciate ligament (ACL) is cited as the most frequently injured ligament in the knee. The standard treatment of ACL injury remains ligament reconstruction followed by a postoperative physiotherapeutic procedure. During the reconstruction, the torn ligament can be replaced with an autograft or an allograft. A synthetic ligament is also one of the available graft options. Synthetic grafts in ruptured ACL treatment have been used as scaffolds, stents, or prostheses. The story of using synthetic materials in ACL deficient knee treatment started in the beginning of the 20th century with the usage of silk and silver fibers...
January 2017: Polimery W Medycynie
https://www.readbyqxmd.com/read/29150988/patterns-and-correlates-of-grip-strength-in-older-americans
#19
Kimberly Forrest, Adelle Williams, Marcy Leeds, Joseph Robare, Thomas Bechard
BACKGROUND: Muscle strength is a sensitive indicator of morbidity and mortality in older adults. Loss of muscle strength contributes to a decline in physical functioning. Hand grip strength is a simple measurement but correlated with total body muscle strength. This study evaluated the patterns and correlates of grip strength among older adults in the United States. METHODS: The grip strength data were analyzed from the National Health and Nutrition Examination Survey...
November 16, 2017: Current Aging Science
https://www.readbyqxmd.com/read/29139278/improving-pain-control-in-diabetic-neuropathy
#20
REVIEW
Peter Paisley, Mick Serpell
Diabetic neuropathy is thought to affect 1.9% of the world’s population and 50% of patients with a diagnosis of diabetes mellitus which would equate to 2.25 million people in the UK. The term diabetic neuropathy includes multiple distinct clinical entities that have been classified under the broad headings of focal and multifocal neuropathies and symmetrical neuropathies. Peripheral diabetic neuropathy, a chronic distal symmetrical predominantly sensory neuropathy, is the most common form of diabetic neuropathy...
March 2017: Practitioner
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