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https://www.readbyqxmd.com/read/27902134/-shout-it-from-the-rooftops
#1
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Former Nursing Standard Nurse of the Year Stacey Atkinson trained in Leeds at a school of nursing attached to a hospital for people with learning disabilities. She qualified in 1990 and worked in residential care and as a community learning disability nurse for children and adults before moving into education. Married with two children, she is now a senior lecturer at the University of Huddersfield. In 2003 she was awarded an MBE for services to children with learning disabilities.
November 30, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27900299/assessment-of-enthesitis-in-patients-with-psoriatic-arthritis-using-clinical-examination-and-ultrasound
#2
Salome Kristensen, Jeppe Hagstrup Christensen, Erik Berg Schmidt, Jens Lykkegaard Olesen, Martin Berg Johansen, Kristian Bakke Arvesen, Annette Schlemmer
BACKGROUND: Enthesitis is a major feature of psoriatic arthritis. However, clinical assessment of enthesitis is known to lack accuracy and have poor interobserver reliability. OBJECTIVE: To determine effect of training on clinical assessment of enthesitis and to compare ultrasonography with clinical examination for the detection of entheseal abnormalities. METHODS: 20 rheumatologists performed repeated assessment of enthesitis in patients with established psoriatic arthritis before and after a 2-hour training session in standardised enthesitis count according to Leeds Enthesitis Index (LEI) and Spondyloarthritis Research Consortium of Canada Enthesitis Index (SPARCC)...
April 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/27899644/the-dbgap-data-browser-a-new-tool-for-browsing-dbgap-controlled-access-genomic-data
#3
Kira M Wong, Kristofor Langlais, Geoffrey S Tobias, Colette Fletcher-Hoppe, Donna Krasnewich, Hilary S Leeds, Laura Lyman Rodriguez, Georgy Godynskiy, Valerie A Schneider, Erin M Ramos, Stephen T Sherry
The database of Genotypes and Phenotypes (dbGaP) Data Browser (https://www.ncbi.nlm.nih.gov/gap/ddb/) was developed in response to requests from the scientific community for a resource that enable view-only access to summary-level information and individual-level genotype and sequence data associated with phenotypic features maintained in the controlled-access tier of dbGaP. Until now, the dbGaP controlled-access environment required investigators to submit a data access request, wait for Data Access Committee review, download each data set and locally examine them for potentially relevant information...
November 29, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27889915/constitutive-regulation-of-the-glutamate-aspartate-transporter-eaat1-by-calcium-calmodulin-dependent-protein-kinase-ii
#4
Aarti R Chawla, Derrick E Johnson, Agnes S Zybura, Benjamin P Leeds, Ross M Nelson, Andy Hudmon
Glutamate clearance by astrocytes is an essential part of normal excitatory neurotransmission. Failure to adapt or maintain low levels of glutamate in the central nervous system is associated with multiple acute and chronic neurodegenerative diseases. The primary excitatory amino acid transporters in human astrocytes are EAAT1 and EAAT2 (GLAST and GLT-1 respectively in rodents). While the inhibition of calcium/calmodulin-dependent kinase (CaMKII), a ubiquitously-expressed serine/threonine protein kinase, results in diminished glutamate uptake in cultured primary rodent astrocytes (Ashpole et al...
November 27, 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27885738/a-collaborative-exploration-of-the-reasons-for-lower-satisfaction-with-services-among-bangladeshi-and-pakistani-social-care-users
#5
Margaret Blake, Alison Bowes, Valdeep Gill, Fatima Husain, Ghazala Mir
This study explored underlying reasons for the expression of dissatisfaction with services among Bangladeshi and Pakistani social care users in England and investigated, using a collaborative approach, how these could be addressed. In-depth interviews were conducted in Birmingham, Leeds and London during 2012-2013 with 63 Bangladeshi, Pakistani and white British service users and 24 social care managers, social workers and care workers. A further 34 cognitive interviews were conducted within the same study...
November 25, 2016: Health & Social Care in the Community
https://www.readbyqxmd.com/read/27885554/short-term-effects-of-a-green-coffee-extract-garcinia-c-ambogia-and-l-carnitine-containing-chewing-gum-on-snack-intake-and-appetite-regulation
#6
Cecilia Bobillo, Graham Finlayson, Ana Martínez, Daniela Fischman, Analisa Beneitez, Alejandro J Ferrero, Belisario E Fernández, Marcos A Mayer
INTRODUCTION: Different studies have assessed the influence of chewing gum to aid control of appetite and reduce food intake. PURPOSE: The aims of the present study were to evaluate the effects of chewing gum on satiety, food hedonics and snack intake and to explore the potential effects of the combination of Garcinia c ambogia, green coffee extract and L-carnitine on satiety, when administered in a gum format. METHODS: This was a prospective study in which 57 subjects randomly received three kinds of treatments, in a crossover design: (1) active gum; (2) placebo gum; and (3) no gum...
November 24, 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/27868328/long-term-outcome-of-the-adjustable-transobturator-male-system-atoms-results-of-a-european-multicentre-study
#7
Alexander Friedl, Sandra Mühlstädt, Roman Zachoval, Alessandro Giammò, Danijel Kivaranovic, Maximilian Rom, Paolo Fornara, Clemens Brössner
OBJECTIVE: To evaluate the long-term effectiveness and safety of the adjustable transobturator male system (ATOMS(®) , Agency for Medical Innovations A.M.I., Feldkirch, Austria) in a European-wide multicentre setting. PATIENTS AND METHODS: In all, 287 men with stress urinary incontinence (SUI) were treated with the ATOMS device between June 2009 and March 2016. Continence parameters (daily pad test/pad use), urodynamics (maximum urinary flow rate, voiding volume, residual urine), and pain/quality of life (QoL) ratings (visual analogue scale/Leeds Assessment of Neuropathic Symptoms and Signs, International Consultation on Incontinence Questionnaire-Short Form [ICIQ-SF]/Patient Global Impression of Improvement [PGI-I]) were compared preoperatively and after intermediate (12 months) as well as after individual maximum follow-up...
November 21, 2016: BJU International
https://www.readbyqxmd.com/read/27866988/the-effects-of-partial-sleep-restriction-and-altered-sleep-timing-on-appetite-and-food-reward
#8
Jessica McNeil, Geneviève Forest, Luzia Jaeger Hintze, Jean-François Brunet, Graham Finlayson, John E Blundell, Éric Doucet
: We examined the effects of partial sleep restriction (PSR) with an advanced wake-time or delayed bedtime on measures of appetite, food reward and subsequent energy intake (EI). Twelve men and 6 women (age: 23 ± 4 years, body fat: 18.8 ± 10.1%) participated in 3 randomized crossover sessions: control (habitual bed- and wake-time), 50% PSR with an advanced wake-time and 50% PSR with a delayed bedtime. Outcome variables included sleep architecture (polysomnography), ad libitum EI (validated food menu), appetite sensations (visual analogue scales), satiety quotient (SQ; mm/100 kcal) and food reward (Leeds Food Preference Questionnaire and the relative-reinforcing value (RRV) of preferred food task)...
November 17, 2016: Appetite
https://www.readbyqxmd.com/read/27853341/effect-of-the-wide-spread-use-of-endovenous-laser-ablation-on-the-treatment-of-varicose-veins-in-japan-a-large-scale-single-institute-study
#9
Masatoshi Jibiki, Tetsuro Miyata, Sachiko Futatsugi, Mitsumasa Iso, Yasutaka Sakanushi
Background and aims: In Japan, stripping under general anesthesia, lumbar anesthesia and tumescent local anesthesia has been used in the treatment of primary varicose veins due to saphenous vein insufficiency. However endovenous laser ablation (EVLA) using a 980 nm diode laser has received National Health Insurance (NHI) coverage in 2011, while EVLA using a 1470 nm diode laser with a radial 2-ring fiber has received coverage in 2014. As a result, the use of EVLA has become widespread in Japan. We herein report on the results of varicose veins treatment at our hospital...
October 1, 2016: Laser Therapy
https://www.readbyqxmd.com/read/27846187/classification-and-treatment-of-chronic-neck-pain-a-longitudinal-cohort-study
#10
Richard Liu, Connie Kurihara, Hue-Ting Tsai, Peter J Silvestri, Michael I Bennett, Paul F Pasquina, Steven P Cohen
BACKGROUND AND OBJECTIVES: Neck pain exerts a steep personal and socioeconomic toll, ranking as the fourth leading cause of disability. The principal determinant in treatment decisions is whether pain is neuropathic or nonneuropathic, as this affects treatment at all levels. Yet, no study has sought to classify neck pain in this manner. METHODS: One hundred participants referred to an urban, academic military treatment facility with a primary diagnosis of neck pain were enrolled and followed up for 6 months...
November 14, 2016: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/27810724/age-related-differences-in-self-harm-presentations-and-subsequent-management-of-adolescents-and-young-adults-at-the-emergency-department
#11
Emma Diggins, Rachael Kelley, David Cottrell, Allan House, David Owens
BACKGROUND: Characteristics of self-harm differ across ages, but there is little work identifying age-related differences in younger people. Young people entering adolescence face emotionally and developmentally different challenges to those entering adulthood. This study investigates how Emergency Department (ED) presentations and management of self-harm differ through adolescence and early adulthood. METHODS: 3782 consecutive self-harm episodes involving 2559 people aged 12-25 years were identified from an existing database of Leeds ED attendances from 2004 to 2007...
October 21, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27810115/effect-of-noise-on-tasks-in-operating-theatres-a-survey-of-the-perceptions-of-healthcare-staff
#12
A D Padmakumar, O Cohen, A Churton, J B Groves, D A Mitchell, P A Brennan
Noise in the operating theatre has an adverse impact on healthcare professionals, both physically and psychologically. It can be distracting, make communication difficult, and contribute to a perceived increase in stress. Staff in theatre must deliver high quality care, and overlook noise as a potentially damaging influence. The aim of this survey was to obtain further information about the perspective of healthcare professionals on how noise can affect their practice and whether it affects their work in theatre...
October 31, 2016: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/27805848/orchil-and-tyrian-purple-two-centuries-of-bedfords-from-leeds
#13
Isabella Whitworth, Zvi C Koren
A two-century-old archive relating to a Leeds dye manufacturer emerged a number of years ago from a Devon attic. Most items in the archive date from the mid-nineteenth century to the first quarter of the twentieth, a period of dye history when natural dyes overlapped with and were gradually replaced by synthetics. The archive contains material relevant to three generations of the Bedford family's manufacturing and research successes, as well as its close connections to the family of William Henry Perkin. A major portion of the archive's contents is connected to the trade in orchil, a purple-producing dye from a lichen on which the early fortunes of the company were based...
November 2, 2016: Ambix
https://www.readbyqxmd.com/read/27801641/a-systematic-review-and-economic-evaluation-of-bisphosphonates-for-the-prevention-of-fragility-fractures
#14
Sarah Davis, Marrissa Martyn-St James, Jean Sanderson, John Stevens, Edward Goka, Andrew Rawdin, Susi Sadler, Ruth Wong, Fiona Campbell, Matt Stevenson, Mark Strong, Peter Selby, Neil Gittoes
BACKGROUND: Fragility fractures are fractures that result from mechanical forces that would not ordinarily result in fracture. OBJECTIVES: To evaluate the clinical effectiveness and safety of bisphosphonates [alendronic acid (Fosamax(®) and Fosamax(®) Once Weekly, Merck Sharp & Dohme Ltd), risedronic acid (Actonel(®) and Actonel Once a Week(®), Warner Chilcott UK Ltd), ibandronic acid (Bonviva(®), Roche Products Ltd) and zoledronic acid (Aclasta(®), Novartis Pharmaceuticals UK Ltd)] for the prevention of fragility fracture and to assess their cost-effectiveness at varying levels of fracture risk...
October 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27770598/development-of-the-japanese-version-of-the-leeds-assessment-of-the-neuropathic-symptoms-and-signs-pain-scale-diagnostic-utility-in-a-clinical-setting
#15
Tatsuya Isomura, Masahiko Sumitani, Ko Matsudaira, Mika Kawaguchi, Reo Inoue, Jun Hozumi, Takeyuki Tanaka, Hirofumi Oshima, Kanto Mori, Shuji Taketomi, Hiroshi Inui, Keitaro Tahara, Ryota Yamagami, Kazuhiro Hayakawa
OBJECTIVE: We aimed to assess the diagnostic utility of the linguistically validated Japanese version of the Leeds Assessment of Neuropathic Symptoms and Signs Pain Scale (LANSS-J) as a screening tool for neuropathic pain in the clinical setting. METHODS: Patients with neuropathic pain or nociceptive pain who were 20 to 85 years of age were included. Sensitivity and specificity using the original cutoff value of 12 were assessed to evaluate the diagnostic utility of the LANSS-J...
October 22, 2016: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/27759139/investigating-the-coverage-dependent-behaviour-of-co-on-gd-pt-111
#16
Elisabeth Therese Ulrikkeholm, Martin Hangaard Hansen, Jan Rossmeisl, Ib Chorkendorff
Gd modified Pt(111) single crystals have been prepared in an ultra high vacuum (UHV). By vacuum deposition of ∼200 Å Gd on a sample heated to 800 °C, a Pt5Gd alloy terminated by a single atomic layer of Pt was formed. Subsequently the surfaces were characterized using low energy electron diffraction (LEED), showing that a highly ordered crystal structure had appeared. To study the molecular dynamics on this surface a detailed study of the CO adsorption on the surface was conducted using temperature programmed desorption (TPD) of CO...
October 19, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27755490/effect-of-topical-morphine-on-acute-and-chronic-postmastectomy-pain-what-is-the-optimum-dose
#17
Sahar Abdel-Baky Mohamed, Hala Saad Abdel-Ghaffar, Shereen Mamdouh Kamal, Khaled Mohamed Fares, Hesham Mahmoud Hamza
BACKGROUND AND OBJECTIVES: Poorly controlled postoperative pain is strongly associated with the development of chronic pain. We aimed to investigate the effect of topical morphine (in 1 of 3 doses: 5, 10, or 15 mg) on acute and chronic neuropathic pain after modified radical mastectomy for cancer breast. METHODS: In this registered clinical trial (ClinicalTrials.gov identifier: NCT02462577), 90 patients were allocated to receive 10 mL plain bupivacaine 0.5% plus either 5, 10, or 15 mg morphine (designated by the group names Morphine5, Morphine10, and Morphine15, respectively)...
October 11, 2016: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/27754987/npwe-model-observer-as-a-validated-alternative-for-contrast-detail-analysis-of-digital-detectors-in-general-radiography
#18
N Van Peteghem, H Bosmans, N W Marshall
To propose and validate a non-prewhitening with eye filter (NPWE) model observer as an alternative means of quantifying and specifying imaging performance for general radiography detectors, in a comparative study with contrast detail analysis and detective quantum efficiency (DQE). Five different x-ray detectors were assessed, covering a range of detector technologies including powder computed radiography (CR), needle CR, and three indirect conversion flat panel digital radiography detectors (DR). For each detector, threshold contrast detail (c-d) detectability was measured using the Leeds TO20 test object...
November 7, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27746994/impact-of-intercostal-paravertebral-neurectomy-on-post-thoracotomy-pain-syndrome-after-thoracotomy-in-lung-cancer-patients-a-randomized-controlled-trial
#19
Aris Koryllos, Astrid Althaus, Marcel Poels, Robin Joppich, Rolf Lefering, Frank Wappler, Wolfram Windisch, Corinna Ludwig, Erich Stoelben
BACKGROUND: Thoracotomy leads to chronic neuropathic pain in up to 50% of patients and is responsible for an impaired quality of life. Intercostal nerve injury has been suggested to be responsible for this pain. In the present study the impact of paravertebral intercostal neurectomy on post thoracotomy pain was assessed. METHODS: In this single center parallel-group randomized controlled trial patients underwent muscle sparing anterolateral thoracotomy and anatomical lung resection for lung cancer...
September 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27735819/treating-wisely-the-surgeon-s-role-in-antibiotic-stewardship
#20
Ira L Leeds, Anne Fabrizio, Sara E Cosgrove, Elizabeth C Wick
Antibiotic resistance continues to receive national attention as a leading public health threat. In 2015, President Barack Obama proposed a National Action Plan to Combat Antibiotic-Resistant Bacteria to curb the rise of "superbugs," bacteria resistant to antibiotics of last resort. Whereas many antibiotics are prescribed appropriately to treat infections, there continue to be a large number of inappropriately prescribed antibiotics. Although much of the national attention with regards to stewardship has focused on primary care providers, there is a significant opportunity for surgeons to embrace this national imperative and improve our practices...
October 4, 2016: Annals of Surgery
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