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https://www.readbyqxmd.com/read/28532202/experiences-of-establishing-an-academic-early-phase-clinical-trials-unit
#1
Sarah R Brown, Debbie Sherratt, Gill Booth, Julia Brown, Fiona Collinson, Walter Gregory, Louise Flanagan
BACKGROUND: Early phase trials are essential in drug development, determining appropriate dose levels and assessing preliminary activity. These trials are undertaken by industry and academia, with increasing collaborations between the two. There is pressure to perform these trials quickly, safely, and robustly. However, there are inherent differences between developing and managing early phase, compared to late phase, drug trials. This article describes an approach to establishing an academically led early phase trial portfolio, highlighting lessons learned and sharing experiences...
May 1, 2017: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/28523394/introduction-framing-post-aids-and-global-health-discourses-in-2015-and-beyond
#2
EDITORIAL
Gráinne O'Connell
This special issue, entitled "Post-AIDS' and Global Health Discourses: Interdisciplinary Perspectives,' emerged from a one day Medical Humanities symposium at the Leeds Centre for Medical Humanities, at the University of Leeds, England, on February 27th 2015. This special issue focusses on the perceived deprioritising of HIV and AIDS in the Sustainable Development Goals, or SDGs, that were launched in 2015. The SDGs function as policy benchmarks for all entities within the United Nations system and they supersede the Millennium Development Goals, or MDGs, which expired in 2015...
May 19, 2017: Journal of Medical Humanities
https://www.readbyqxmd.com/read/28519898/evaluating-the-effect-of-a-year-long-film-focused-environmental-education-program-on-ugandan-student-knowledge-of-and-attitudes-toward-great-apes
#3
Austin Leeds, Kristen E Lukas, Corinne J Kendall, Michelle A Slavin, Elizabeth A Ross, Martha M Robbins, Dagmar van Weeghel, Richard A Bergl
Films, as part of a larger environmental education program, have the potential to influence the knowledge and attitudes of viewers. However, to date, no evaluations have been published reporting the effectiveness of films, when used within primate range countries as part of a conservation themed program. The Great Ape Education Project was a year-long environmental education program implemented in Uganda for primary school students living adjacent to Kibale National Park (KNP) and Bwindi Impenetrable National Park (BINP)...
May 18, 2017: American Journal of Primatology
https://www.readbyqxmd.com/read/28516996/growth-of-two-dimensional-silica-and-aluminosilicate-bilayers-on-pd-111-from-incommensurate-to-commensurate-crystalline
#4
Jin-Hao Jhang, Chao Zhou, Omur E Dagdeviren, Gregory S Hutchings, Udo D Schwarz, Eric I Altman
Two-dimensional (2D) silica (SiO2) and aluminosilicate (AlSi3O8) bilayers grown on Pd(111) were fabricated and systematically studied using ultrahigh vacuum surface analysis in combination with theoretical methods, including Auger electron spectroscopy, X-ray photoelectron spectroscopy, low-energy electron diffraction (LEED), scanning tunneling microscopy (STM), and density functional theory. Based on LEED results, both SiO2 and AlSi3O8 bilayers start ordering above 850 K in 2 × 10(-6) Torr oxygen. Both bilayers show hexagonal LEED patterns with a periodicity approximately twice that of the Pd(111) surface...
May 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28508959/surgical-treatment-of-patellar-instability-clinical-and-radiological-outcome-after-medial-patellofemoral-ligament-reconstruction-and-tibial-tuberosity-medialisation
#5
Stefan Lobner, Christine Krauss, Frank Reichwein, Thilo Patzer, Wolfgang Nebelung, Arne J Venjakob
INTRODUCTION: The aim of this retrospective study was to analyse clinical and radiological outcome after medial patellofemoral ligament reconstruction (MPFLR) and tibial tuberosity medialisation (TTM) in patients with recurrent patellar instability. MATERIALS AND METHODS: Thirty-five patients were included between 2008 and 2012. According to defined criteria such as tibial tuberosity-trochlear groove (TTTG) distance, hyperpression on the lateral patella facet and lateral retropatellar cartilage damage either MPFLR (group A) or TTM (group B) was performed: 18 patients underwent TTM, the other 17 patients underwent MPFLR...
May 16, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28507390/high-quality-pvd-graphene-growth-by-fullerene-decomposition-on-cu-foils
#6
J Azpeitia, G Otero-Irurueta, I Palacio, J I Martinez, N Ruiz Del Árbol, G Santoro, A Gutiérrez, L Aballe, M Foerster, M Kalbac, V Vales, F J Mompeán, M García-Hernández, J A Martín-Gago, C Munuera, M F López
We present a new protocol to grow large-area, high-quality single-layer graphene on Cu foils at relatively low temperatures. We use C60 molecules evaporated in ultra high vacuum conditions as carbon source. This clean environment results in a strong reduction of oxygen-containing groups as depicted by X-ray photoelectron spectroscopy (XPS). Unzipping of C60 is thermally promoted by annealing the substrate at 800ºC during evaporation. The graphene layer extends over areas larger than the Cu crystallite size, although it is changing its orientation with respect to the surface in the wrinkles and grain boundaries, producing a modulated ring in the low energy electron diffraction (LEED) pattern...
August 2017: Carbon
https://www.readbyqxmd.com/read/28506010/re-evaluation-of-a-leed-platinum-building-occupant-experiences-of-health-and-comfort
#7
Julie Dorsey, Alan Hedge
BACKGROUND: There is a need to better understand the perceived experiences of workers in green buildings as the literature to this point has been mixed. OBJECTIVES: To re-evaluate occupant experiences within a LEED platinum building and investigate current experiences in general. METHODS: An online post occupancy evaluation (POE) survey of 62 occupants of LEED Platinum building on a US college campus is reported. The online survey addressed indoor environmental quality in relation to health, productivity and satisfaction...
May 6, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/28495661/virtual-reality-as-an-adjunct-home-therapy-in-chronic-pain-management-an-exploratory-study
#8
Bernie Garrett, Tarnia Taverner, Paul McDade
BACKGROUND: Virtual reality (VR) therapy has been successfully used as an adjunct therapy for the management of acute pain in adults and children, and evidence of potential efficacy in other health applications is growing. However, minimal research exists on the value of VR as an intervention for chronic pain. OBJECTIVE: This case series examined the value of VR to be used as an adjunctive therapy for chronic pain patients in their own homes. METHODS: An exploratory approach using a case series and personal interviews was used...
May 11, 2017: JMIR Medical Informatics
https://www.readbyqxmd.com/read/28466194/the-role-of-laser-power-and-pullback-velocity-in-the-endovenous-laser-ablation-efficacy-an-experimental-study
#9
N Yu Ignatieva, O L Zakharkina, C V Masayshvili, S V Maximov, V N Bagratashvili, V V Lunin
Endovenous laser ablation is an effective and minimally invasive alternative to surgical removal of incompetent veins. However, many controversies concerning optimal laser parameters usage in this procedure still remain. The purpose of this experimental study was to assess the adequate parameters required for vein wall destruction and to evaluate the role of fiber pullback velocity on vessel wall degradation. Varicose vein segments were treated with 1470-nm diode laser 3 to 9.5 W in power. The fiber moved through the vein at a velocity of 0...
May 2, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28451811/prospective-clinical-and-pharmacological-evaluation-of-the-delcath-system-s-second-generation-gen2-hemofiltration-system-in-patients-undergoing-percutaneous-hepatic-perfusion-with-melphalan
#10
Eleonora M de Leede, Mark C Burgmans, T Susanna Meijer, Christian H Martini, Fred G J Tijl, Jaap Vuyk, Arian R van Erkel, Cornelis J H van der Velde, Ellen Kapiteijn, Alexander L Vahrmeijer
INTRODUCTION: Percutaneous hepatic perfusion (PHP) with melphalan is an effective treatment for patients with hepatic metastases, but associated with high rates of bone marrow depression. To reduce systemic toxicity, improvements have been made to the filtration system. In pre-clinical studies, the Delcath System's GEN2 filter was superior to the first-generation filters. In this clinical study, we analysed the pharmacokinetics and toxicity of PHP using the new GEN2 filter. METHODS AND MATERIALS: Starting February 2014, two prospective phase II studies were initiated in patients with hepatic metastases from ocular melanoma or colorectal cancer...
April 27, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28447807/developing-a-measure-to-assess-identity-reconstruction-in-patients-with-multiple-sclerosis
#11
Lara M Stepleman, Rebecca M Floyd, Abbey Valvano-Kelley, Lauren Penwell-Waines, Sarah Wonn, Danielle Crethers, Rebecca Rahn, Suzanne Smith
PURPOSE/OBJECTIVE: To develop and test initial validation of a theory-driven quantitative measure of identity reconstruction in patients with multiple sclerosis (MS) based upon previous qualitative research. Research Method/Design: This study uses a cross-sectional survey design, in which 137 patients living with MS were recruited from an outpatient MS Center in the Southeastern U.S. Participants completed demographic items, Identity Reconstruction Assessment Scales (IRAS), Patient Determined Disease Steps, Medical Outcomes Study Measures of Patient Adherence, Chronic Disease Self-Efficacy Scale, Hospital Anxiety and Depression Scale, Leeds MS Quality of Life Questionnaire, MS-Related Stigma Scale, and Posttraumatic Growth Inventory-Short Form...
April 27, 2017: Rehabilitation Psychology
https://www.readbyqxmd.com/read/28441252/paget-s-disease-of-the-vulva-a-review-of-20-years-experience
#12
Raghava Parashurama, Vivek Nama, Richard Hutson
BACKGROUND: Extramammary Paget's disease is a rare condition, and the vulva is a common site for it to occur. Despite this, there is a paucity of literature on Paget's disease of the vulva (VPD). A Cochrane meta-analysis could not draw any conclusions on interventions in VPD. Our aim was to review our practice and improve further management of VPD in our center. METHODS: We reviewed all the cases presented to Leeds Gynaecological Oncology Centre between 1988 and 2016...
May 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28440034/role-of-transcranial-direct-current-stimulation-on-reduction-of-postsurgical-opioid-consumption-and-pain-in-total-knee-arthroplasty-double-randomized-clinical-trial
#13
E M Khedr, E S A Sharkawy, A M A Attia, N M Ibrahim Osman, Z M Sayed
BACKGROUND: Postoperative pain control is an important factor in determining recovery in total knee arthroplasty (TKA).The aim of the study was to assess the efficacy of 4 sessions of transcranial direct current stimulation (tDCS) over primary motor cortex (M1) in patients undergoing unilateral TKA. MATERIALS: Fifty patients undergoing TKA were included in the study. They were divided randomly into two groups (25 patients for each, using closed envelopes): real tDCS (2 mA, 20 min, with anodal stimulation applied over M1 postoperative for 4 consecutive days) and sham tDCS...
April 25, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28408544/cost-and-outcome-of-behavioural-activation-versus-cognitive-behavioural-therapy-for-depression-cobra-a-qualitative-process-evaluation
#14
Katie Finning, David A Richards, Lucy Moore, David Ekers, Dean McMillan, Paul A Farrand, Heather A O'Mahen, Edward R Watkins, Kim A Wright, Emily Fletcher, Shelley Rhodes, Rebecca Woodhouse, Faye Wray
OBJECTIVE: To explore participant views on acceptability, mechanisms of change and impact of behavioural activation (BA) delivered by junior mental health workers (MHWs) versus cognitive behavioural therapy (CBT) delivered by professional psychotherapists. DESIGN: Semistructured qualitative interviews analysed using a framework approach. PARTICIPANTS: 36 participants with major depressive disorder purposively sampled from a randomised controlled trial of BA versus CBT (the COBRA trial)...
April 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28403994/risk-of-gastrointestinal-bleeding-with-direct-oral-anticoagulants-a-systematic-review-and-network-meta-analysis
#15
Nick Burr, Katie Lummis, Ruchit Sood, John Samuel Kane, Aaron Corp, Venkataraman Subramanian
BACKGROUND: Direct oral anticoagulants are increasingly used for a wide range of indications. However, data are conflicting about the risk of major gastrointestinal bleeding with these drugs. We compared the risk of gastrointestinal bleeding with direct oral anticoagulants, warfarin, and low-molecular-weight heparin. METHODS: For this systematic review and meta-analysis, we searched MEDLINE and Embase from database inception to April 1, 2016, for prospective and retrospective studies that reported the risk of gastrointestinal bleeding with use of a direct oral anticoagulant compared with warfarin or low-molecular-weight heparin for all indications...
February 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28403719/setting-the-bar
#16
Erin Dean
Amy Cawthorne, an advanced clinical practitioner in emergency care in Leeds, is one of the first emergency nurses in the country to reach a national standard for her role.
April 13, 2017: Emergency Nurse: the Journal of the RCN Accident and Emergency Nursing Association
https://www.readbyqxmd.com/read/28398946/high-intensity-interval-training-appetite-and-reward-value-of-food-in-the-obese
#17
Catia Martins, Irina Aschehoug, Marit Ludviksen, Jens Holst, Graham Finlayson, Ulrik Wisloff, Linda Morgan, Neil King, Bård Kulseng
PURPOSE: Studies on the impact of chronic interval training on appetite in the obese population are scarce. The aim of this study was to determine the effect of 12 weeks of isocaloric programs of moderate-intensity continuous training (MICT) or high-intensity interval training (HIIT), or a short-duration HIIT (1/2HIIT), on subjective feelings of appetite, appetite-related hormones and reward value of food in sedentary obese individuals. METHODS: Forty-six sedentary obese individuals (30 women and 16 men), with a BMI of 33...
April 11, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28395114/abstracts-presented-at-the-winter-meeting-of-the-british-association-of-clinical-anatomists-on-15th-december-2016-at-the-leeds-institute-of-medical-education-university-of-leeds-leeds-united-kingdom
#18
https://www.readbyqxmd.com/read/28379086/boosting-clinical-performance-the-impact-of-enhanced-final-year-placements
#19
D V H Williams, A M Reid, M Homer
BACKGROUND: This study follows on from a study that investigated how to develop effective final year medical student assistantship placements, using multidisciplinary clinical teams in planning and delivery. AIMS: This study assessed the effects on objective structured clinical examination (OSCE) performance of the in-course enhanced "super-assistantship" placement introduced to a randomly selected sample of 2013-14 final year medical students at Leeds medical school...
April 2017: Medical Teacher
https://www.readbyqxmd.com/read/28372858/visual-field-progression-in-patients-with-primary-angle-closure-glaucoma-using-pointwise-linear-regression-analysis
#20
Sushma Verma, Monisha E Nongpiur, Eray Atalay, Xin Wei, Rahat Husain, David Goh, Shamira A Perera, Tin Aung
PURPOSE: To evaluate visual field (VF) progression and rate of glaucomatous VF loss in patients with primary angle-closure glaucoma (PACG) using pointwise linear regression (PLR) trend analysis. DESIGN: Clinic-based retrospective study. PARTICIPANTS: Primary angle-closure glaucoma patients with 5 or more reliable VF tests and with 5 years or more of follow-up. METHODS: Visual field progression was assessed by PROGRESSOR software version 3...
March 31, 2017: Ophthalmology
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