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https://www.readbyqxmd.com/read/28655167/identification-of-transcript-regulatory-patterns-in-cell-differentiation
#1
Arief Gusnanto, John Paul Gosling, Christopher Pope
Motivation: Studying transcript regulatory patterns in cell differentiation is critical in understanding its complex nature of the formation and function of different cell types. This is done usually by measuring gene expression at different stages of the cell differentiation. However, if the gene expression data available are only from the mature cells, we have some challenges in identifying transcript regulatory patterns that govern the cell differentiation. Results: We propose to exploit the information of the lineage of cell differentiation in terms of correlation structure between cell types...
June 24, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28640727/urology-study-day-leeds-2016
#2
Carmel Ramage, Magda Kujawa, Siva Namasivayam, Ania Swann, Neil Wigglesworth, Catherine Heavens, Claire Finan
Last year, urology nurses and continence nurse specialists took part in the second of two study days on urology. The events were delivered by the British Journal of Nursing with programme support in association with the British Association of Urology Nurses and Hollister Inc. Below are reports of some of the presentations.
June 22, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28637543/gracilis-flap-for-perineal-closures-in-minimally-invasive-abdominoperineal-resection
#3
Ira L Leeds, James P Taylor, Marcos Pozo, Bashar Safar, Justin M Sacks, Sandy H Fang
No abstract text is available yet for this article.
June 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28633479/geographical-inequalities-in-uptake-of-nhs-funded-eye-examinations-poisson-modelling-of-small-area-data-for-essex-uk
#4
Darren Shickle, Tracey M Farragher, Chris J Davey, Sarah V Slade, James Syrett
Background: Small-area analysis of National Health Service (NHS)-funded sight test uptake in Leeds showed significant inequalities in access among people aged <16 or ≥60. Methods: Data were extracted from 604 126 valid General Ophthalmic Services (GOS)1 claim forms for eye examinations for Essex residents between October 2013 and July 2015. Expected GOS1 uptake for each lower super output area was based on England annual uptake. Poisson regression modelling explored associations in GOS1 uptake ratio with deprivation...
June 17, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/28621924/revealing-the-crystalline-integrity-of-wafer-scale-graphene-on-sio2-si-an-azimuthal-rheed-approach
#5
Zonghuan Lu, Xin Sun, Yu Xiang, Morris A Washington, Gwo-Ching Wang, Toh-Ming Lu
The symmetry of graphene is usually determined by low-energy electron diffraction (LEED) method when the graphene is on the conductive substrates. But LEED cannot handle graphene transferred to SiO2/Si substrates due to the charging effect. While transmission electron microscopy can generate electron diffraction on post-transferred graphene, this method is too localized. Herein, we employed an azimuthal reflection high-energy electron diffraction (RHEED) method to construct the reciprocal space mapping and determine the symmetry of wafer size graphene both pre- and post-transfer...
June 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28616042/cerebral-mechanism-of-puncturing-at-he-mu-point-combination-for-functional-dyspepsia-study-protocol-for-a-randomized-controlled-parallel-trial
#6
Shuai Yin, Yuan Chen, Du Lei, Rui-Rui Sun, Ting-Ting Ma, Pei-Min Feng, Zhao-Xuan He, Xue-Ling Suo, Pei-Hong Ma, Yu-Zhu Qu, Ke Qiu, Miao-Miao Jing, Qi-Yong Gong, Fan-Rong Liang, Jiao Chen, Fang Zeng
Acupuncture is widely used to treat functional dyspepsia with satisfactory outcomes. Combination of the He and Mu acupoints is commonly used and has a synergistic effect on functional dyspepsia; however, its underlying mechanisms remain unclear. Therefore, a randomized controlled parallel clinical trial is currently underway at Chengdu University of Traditional Chinese Medicine, China. This trial is designed to explore the efficacy of and central responses to the He-Mu point combination in patients with functional dyspepsia using functional magnetic resonance imaging...
May 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28616004/development-and-validation-of-arabic-version-of-the-neuropathic-pain-questionnaire-short-form
#7
Abdullah Sulieman Terkawi, Miroslav Misha Backonja, Abdullah Abolkhair, Sameeh Almaharbi, Jaya Joy, Farida Foula, Mousa Alswiti, Yazzed Sulieman Terkawi, Tariq Al-Zhahrani, Faris Saeed Alghamdi, Siny Tsang
INTRODUCTION: The Neuropathic Pain Questionnaire-Short Form (NPQ-SF) is the shortest diagnostic tool for the assessment of neuropathic pain, designed with the goal to differentiate between neuropathic and nonneuropathic pain. The aim of this study was to translate, culturally adapt, and validate the NPQ-SF questionnaire in Arabic. METHODS: A systematic translation process was used to translate the original English NPQ-SF into Arabic. After the pilot study, the Arabic version was validated among patients with chronic pain in two tertiary care centers...
May 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28616002/development-and-validation-of-arabic-version-of-the-douleur-neuropathique-4-questionnaire
#8
Abdullah Sulieman Terkawi, Abdullah Abolkhair, Bouhassira Didier, Tariq Alzhahrani, Mazen Alsohaibani, Yazzed Sulieman Terkawi, Yousuf Almoqbali, Yasser Younis Tolba, Evelyn Pangililan, Farida Foula, Siny Tsang
INTRODUCTION: The douleur neuropathique 4 (DN4) questionnaire is a widely used tool for diagnosis of neuropathic pain (NP). The aim was to translate, culturally adapt, and validate the DN4 questionnaire in Arabic. METHODS: A systematic translation process was used to translate the original English DN4 into Arabic. After the pilot study, the Arabic version was validated among patients with chronic pain in two tertiary care centers. The reliability of the translated version was examined using internal consistency, test-retest reliability, and intraclass correlation coefficients...
May 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28615999/development-and-validation-of-arabic-version-of-the-short-form-mcgill-pain-questionnaire
#9
Abdullah Sulieman Terkawi, Siny Tsang, Abdullah Abolkhair, Mohammed Alsharif, Mousa Alswiti, Adwa Alsadoun, Usama Saleh AlZoraigi, Saleh F Aldhahri, Tariq Al-Zhahrani, Khaild Ali Altirkawi
INTRODUCTION: The Short-Form McGill Pain Questionnaire (SF-MPQ) is a widely used tool for qualitative and quantitative pain assessment. Our aim was to translate, culturally adapt, and validate the SF-MPQ in Arabic. METHODS: A systematic translation process was used to translate the original English SF-MPQ into Arabic. After the pilot study, we validated our version in patients with chronic pain at two tertiary care centers. We tested the reliability of our version using internal consistency and test-retest reliability...
May 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28602449/what-are-the-barriers-and-facilitators-for-the-self-management-of-chronic-pain-with-and-without-neuropathic-characteristics
#10
Elizabeth G Mann, Margaret B Harrison, Sandra LeFort, Elizabeth G VanDenKerkhof
Chronic pain requires affected individuals to self-manage their health. This study compared barriers and facilitators of self-management in two groups of people with chronic pain: those with and without neuropathic characteristics. A cross-sectional survey study of community-dwelling Canadians was conducted. The sample (n = 710) included randomly selected participants who reported chronic pain. The Self-Report Leeds Assessment of Neuropathic Symptoms and Signs was used to screen for neuropathic characteristics...
June 8, 2017: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
https://www.readbyqxmd.com/read/28594612/what-compassion-means-to-me
#11
Clare Price-Dowd
In the first instalment in a series of blogs, Clare Price-Dowd, Senior Programme Lead, NHS Leadership Academy, Leeds, talks about her personal experience of compassionate nursing and discusses why it is so important in the NHS.
June 8, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28580366/nanotip-based-photoelectron-microgun-for-ultrafast-leed
#12
Gero Storeck, Simon Vogelgesang, Murat Sivis, Sascha Schäfer, Claus Ropers
We present the design and fabrication of a micrometer-scale electron gun for the implementation of ultrafast low-energy electron diffraction from surfaces. A multi-step process involving photolithography and focused-ion-beam nanostructuring is used to assemble and electrically contact the photoelectron gun, which consists of a nanotip photocathode in a Schottky geometry and an einzel lens for beam collimation. We characterize the low-energy electron pulses by a transient electric field effect and achieve pulse durations of 1...
July 2017: Structural Dynamics (Melville, N.Y.)
https://www.readbyqxmd.com/read/28551378/radical-operation-for-hilar-cholangiocarcinoma-in-comparable-eastern-and-western-centers-outcome-analysis-and-prognostic-factors
#13
Norihisa Kimura, Alastair L Young, Yoshikazu Toyoki, Judith I Wyatt, Giles J Toogood, Ernest Hidalgo, K Rajendra Prasad, Daisuke Kudo, Keinosuke Ishido, Kenichi Hakamada, J Peter A Lodge
BACKGROUND: Extensive resection for hilar cholangiocarcinoma is the most effective treatment, but high morbidity and poor prognosis remain concerns. Previous data have shown marked differences in outcomes between comparable Eastern and Western centers. We compared the outcomes of the management for hilar cholangiocarcinoma at one Japanese and one British institution with comparable experience. METHODS: Of 298 consecutive patients with hilar cholangiocarcinoma evaluated at Hirosaki University Hospital, Japan and St...
May 24, 2017: Surgery
https://www.readbyqxmd.com/read/28532202/experiences-of-establishing-an-academic-early-phase-clinical-trials-unit
#14
Sarah R Brown, Debbie Sherratt, Gill Booth, Julia Brown, Fiona Collinson, Walter Gregory, Louise Flanagan
BACKGROUND: Early phase trials are essential in drug development, determining appropriate dose levels and assessing preliminary activity. These trials are undertaken by industry and academia, with increasing collaborations between the two. There is pressure to perform these trials quickly, safely, and robustly. However, there are inherent differences between developing and managing early phase, compared to late phase, drug trials. This article describes an approach to establishing an academically led early phase trial portfolio, highlighting lessons learned and sharing experiences...
May 1, 2017: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/28523394/introduction-framing-post-aids-and-global-health-discourses-in-2015-and-beyond
#15
EDITORIAL
Gráinne O'Connell
This special issue, entitled "Post-AIDS' and Global Health Discourses: Interdisciplinary Perspectives,' emerged from a one day Medical Humanities symposium at the Leeds Centre for Medical Humanities, at the University of Leeds, England, on February 27th 2015. This special issue focusses on the perceived deprioritising of HIV and AIDS in the Sustainable Development Goals, or SDGs, that were launched in 2015. The SDGs function as policy benchmarks for all entities within the United Nations system and they supersede the Millennium Development Goals, or MDGs, which expired in 2015...
May 19, 2017: Journal of Medical Humanities
https://www.readbyqxmd.com/read/28519898/evaluating-the-effect-of-a-year-long-film-focused-environmental-education-program-on-ugandan-student-knowledge-of-and-attitudes-toward-great-apes
#16
Austin Leeds, Kristen E Lukas, Corinne J Kendall, Michelle A Slavin, Elizabeth A Ross, Martha M Robbins, Dagmar van Weeghel, Richard A Bergl
Films, as part of a larger environmental education program, have the potential to influence the knowledge and attitudes of viewers. However, to date, no evaluations have been published reporting the effectiveness of films, when used within primate range countries as part of a conservation themed program. The Great Ape Education Project was a year-long environmental education program implemented in Uganda for primary school students living adjacent to Kibale National Park (KNP) and Bwindi Impenetrable National Park (BINP)...
May 18, 2017: American Journal of Primatology
https://www.readbyqxmd.com/read/28516996/growth-of-two-dimensional-silica-and-aluminosilicate-bilayers-on-pd-111-from-incommensurate-to-commensurate-crystalline
#17
Jin-Hao Jhang, Chao Zhou, Omur E Dagdeviren, Gregory S Hutchings, Udo D Schwarz, Eric I Altman
Two-dimensional (2D) silica (SiO2) and aluminosilicate (AlSi3O8) bilayers grown on Pd(111) were fabricated and systematically studied using ultrahigh vacuum surface analysis in combination with theoretical methods, including Auger electron spectroscopy, X-ray photoelectron spectroscopy, low-energy electron diffraction (LEED), scanning tunneling microscopy (STM), and density functional theory. Based on LEED results, both SiO2 and AlSi3O8 bilayers start ordering above 850 K in 2 × 10(-6) Torr oxygen. Both bilayers show hexagonal LEED patterns with a periodicity approximately twice that of the Pd(111) surface...
May 31, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28508959/surgical-treatment-of-patellar-instability-clinical-and-radiological-outcome-after-medial-patellofemoral-ligament-reconstruction-and-tibial-tuberosity-medialisation
#18
Stefan Lobner, Christine Krauss, Frank Reichwein, Thilo Patzer, Wolfgang Nebelung, Arne J Venjakob
INTRODUCTION: The aim of this retrospective study was to analyse clinical and radiological outcome after medial patellofemoral ligament reconstruction (MPFLR) and tibial tuberosity medialisation (TTM) in patients with recurrent patellar instability. MATERIALS AND METHODS: Thirty-five patients were included between 2008 and 2012. According to defined criteria such as tibial tuberosity-trochlear groove (TTTG) distance, hyperpression on the lateral patella facet and lateral retropatellar cartilage damage either MPFLR (group A) or TTM (group B) was performed: 18 patients underwent TTM, the other 17 patients underwent MPFLR...
May 16, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28507390/high-quality-pvd-graphene-growth-by-fullerene-decomposition-on-cu-foils
#19
J Azpeitia, G Otero-Irurueta, I Palacio, J I Martinez, N Ruiz Del Árbol, G Santoro, A Gutiérrez, L Aballe, M Foerster, M Kalbac, V Vales, F J Mompeán, M García-Hernández, J A Martín-Gago, C Munuera, M F López
We present a new protocol to grow large-area, high-quality single-layer graphene on Cu foils at relatively low temperatures. We use C60 molecules evaporated in ultra high vacuum conditions as carbon source. This clean environment results in a strong reduction of oxygen-containing groups as depicted by X-ray photoelectron spectroscopy (XPS). Unzipping of C60 is thermally promoted by annealing the substrate at 800ºC during evaporation. The graphene layer extends over areas larger than the Cu crystallite size, although it is changing its orientation with respect to the surface in the wrinkles and grain boundaries, producing a modulated ring in the low energy electron diffraction (LEED) pattern...
August 2017: Carbon
https://www.readbyqxmd.com/read/28506010/re-evaluation-of-a-leed-platinum-building-occupant-experiences-of-health-and-comfort
#20
Julie Dorsey, Alan Hedge
BACKGROUND: There is a need to better understand the perceived experiences of workers in green buildings as the literature to this point has been mixed. OBJECTIVES: To re-evaluate occupant experiences within a LEED platinum building and investigate current experiences in general. METHODS: An online post occupancy evaluation (POE) survey of 62 occupants of LEED Platinum building on a US college campus is reported. The online survey addressed indoor environmental quality in relation to health, productivity and satisfaction...
2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
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