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https://www.readbyqxmd.com/read/28447807/developing-a-measure-to-assess-identity-reconstruction-in-patients-with-multiple-sclerosis
#1
Lara M Stepleman, Rebecca M Floyd, Abbey Valvano-Kelley, Lauren Penwell-Waines, Sarah Wonn, Danielle Crethers, Rebecca Rahn, Suzanne Smith
PURPOSE/OBJECTIVE: To develop and test initial validation of a theory-driven quantitative measure of identity reconstruction in patients with multiple sclerosis (MS) based upon previous qualitative research. Research Method/Design: This study uses a cross-sectional survey design, in which 137 patients living with MS were recruited from an outpatient MS Center in the Southeastern U.S. Participants completed demographic items, Identity Reconstruction Assessment Scales (IRAS), Patient Determined Disease Steps, Medical Outcomes Study Measures of Patient Adherence, Chronic Disease Self-Efficacy Scale, Hospital Anxiety and Depression Scale, Leeds MS Quality of Life Questionnaire, MS-Related Stigma Scale, and Posttraumatic Growth Inventory-Short Form...
April 27, 2017: Rehabilitation Psychology
https://www.readbyqxmd.com/read/28441252/paget-s-disease-of-the-vulva-a-review-of-20-years-experience
#2
Raghava Parashurama, Vivek Nama, Richard Hutson
BACKGROUND: Extramammary Paget's disease is a rare condition, and the vulva is a common site for it to occur. Despite this, there is a paucity of literature on Paget's disease of the vulva (VPD). A Cochrane meta-analysis could not draw any conclusions on interventions in VPD. Our aim was to review our practice and improve further management of VPD in our center. METHODS: We reviewed all the cases presented to Leeds Gynaecological Oncology Centre between 1988 and 2016...
May 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28440034/role-of-transcranial-direct-current-stimulation-on-reduction-of-postsurgical-opioid-consumption-and-pain-in-total-knee-arthroplasty-double-randomized-clinical-trial
#3
E M Khedr, E S A Sharkawy, A M A Attia, N M Ibrahim Osman, Z M Sayed
BACKGROUND: Postoperative pain control is an important factor in determining recovery in total knee arthroplasty (TKA).The aim of the study was to assess the efficacy of 4 sessions of transcranial direct current stimulation (tDCS) over primary motor cortex (M1) in patients undergoing unilateral TKA. MATERIALS: Fifty patients undergoing TKA were included in the study. They were divided randomly into two groups (25 patients for each, using closed envelopes): real tDCS (2 mA, 20 min, with anodal stimulation applied over M1 postoperative for 4 consecutive days) and sham tDCS...
April 25, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28408544/cost-and-outcome-of-behavioural-activation-versus-cognitive-behavioural-therapy-for-depression-cobra-a-qualitative-process-evaluation
#4
Katie Finning, David A Richards, Lucy Moore, David Ekers, Dean McMillan, Paul A Farrand, Heather A O'Mahen, Edward R Watkins, Kim A Wright, Emily Fletcher, Shelley Rhodes, Rebecca Woodhouse, Faye Wray
OBJECTIVE: To explore participant views on acceptability, mechanisms of change and impact of behavioural activation (BA) delivered by junior mental health workers (MHWs) versus cognitive behavioural therapy (CBT) delivered by professional psychotherapists. DESIGN: Semistructured qualitative interviews analysed using a framework approach. PARTICIPANTS: 36 participants with major depressive disorder purposively sampled from a randomised controlled trial of BA versus CBT (the COBRA trial)...
April 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28403994/risk-of-gastrointestinal-bleeding-with-direct-oral-anticoagulants-a-systematic-review-and-network-meta-analysis
#5
Nick Burr, Katie Lummis, Ruchit Sood, John Samuel Kane, Aaron Corp, Venkataraman Subramanian
BACKGROUND: Direct oral anticoagulants are increasingly used for a wide range of indications. However, data are conflicting about the risk of major gastrointestinal bleeding with these drugs. We compared the risk of gastrointestinal bleeding with direct oral anticoagulants, warfarin, and low-molecular-weight heparin. METHODS: For this systematic review and meta-analysis, we searched MEDLINE and Embase from database inception to April 1, 2016, for prospective and retrospective studies that reported the risk of gastrointestinal bleeding with use of a direct oral anticoagulant compared with warfarin or low-molecular-weight heparin for all indications...
February 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28403719/setting-the-bar
#6
Erin Dean
Amy Cawthorne, an advanced clinical practitioner in emergency care in Leeds, is one of the first emergency nurses in the country to reach a national standard for her role.
April 13, 2017: Emergency Nurse: the Journal of the RCN Accident and Emergency Nursing Association
https://www.readbyqxmd.com/read/28398946/high-intensity-interval-training-appetite-and-reward-value-of-food-in-the-obese
#7
Catia Martins, Irina Aschehoug, Marit Ludviksen, Jens Holst, Graham Finlayson, Ulrik Wisloff, Linda Morgan, Neil King, Bård Kulseng
PURPOSE: Studies on the impact of chronic interval training on appetite in the obese population are scarce. The aim of this study was to determine the effect of 12 weeks of isocaloric programs of moderate-intensity continuous training (MICT) or high-intensity interval training (HIIT), or a short-duration HIIT (1/2HIIT), on subjective feelings of appetite, appetite-related hormones and reward value of food in sedentary obese individuals. METHODS: Forty-six sedentary obese individuals (30 women and 16 men), with a BMI of 33...
April 11, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28395114/abstracts-presented-at-the-winter-meeting-of-the-british-association-of-clinical-anatomists-on-15th-december-2016-at-the-leeds-institute-of-medical-education-university-of-leeds-leeds-united-kingdom
#8
https://www.readbyqxmd.com/read/28379086/boosting-clinical-performance-the-impact-of-enhanced-final-year-placements
#9
D V H Williams, A M Reid, M Homer
BACKGROUND: This study follows on from a study that investigated how to develop effective final year medical student assistantship placements, using multidisciplinary clinical teams in planning and delivery. AIMS: This study assessed the effects on objective structured clinical examination (OSCE) performance of the in-course enhanced "super-assistantship" placement introduced to a randomly selected sample of 2013-14 final year medical students at Leeds medical school...
April 2017: Medical Teacher
https://www.readbyqxmd.com/read/28372858/visual-field-progression-in-patients-with-primary-angle-closure-glaucoma-using-pointwise-linear-regression-analysis
#10
Sushma Verma, Monisha E Nongpiur, Eray Atalay, Xin Wei, Rahat Husain, David Goh, Shamira A Perera, Tin Aung
PURPOSE: To evaluate visual field (VF) progression and rate of glaucomatous VF loss in patients with primary angle-closure glaucoma (PACG) using pointwise linear regression (PLR) trend analysis. DESIGN: Clinic-based retrospective study. PARTICIPANTS: Primary angle-closure glaucoma patients with 5 or more reliable VF tests and with 5 years or more of follow-up. METHODS: Visual field progression was assessed by PROGRESSOR software version 3...
March 31, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28370427/ventilation-rates-in-recently-constructed-us-school-classrooms
#11
Stuart Batterman, Feng-Chiao Su, Andrew Wald, Floyd Watkins, Christopher Godwin, Geoffrey Thun
Low ventilation rates (VRs) in schools have been associated with absenteeism, poorer academic performance, and teacher dissatisfaction. We measured VRs in 37 recently constructed or renovated and mechanically-ventilated U.S. schools, including LEED and EnergyStar-certified buildings, using CO2 and the steady-state, build-up, decay and transient mass balance methods. The transient mass balance method better matched conditions (specifically, changes in occupancy) and minimized biases seen in the other methods...
April 2, 2017: Indoor Air
https://www.readbyqxmd.com/read/28369635/characterization-and-experimental-measurements-of-scatter-dose-at-cardiologist-s-eyes-during-paediatric-interventional-cardiology-procedures-in-costa-rica
#12
Carlos Ubeda, Luisa Salazar, Viviana Retana, Freddy Santos, Lourdes Salvador, Carlos Sáenz, Cristhian Quesada, Manuel Gavarrete, Marcela Picado, Luis Arce
This paper presents the results of the first characterization and experimental measurements of scatter dose at cardiologist's eyes for the only X-ray system that performs all paediatric Interventional cardiology procedures in Costa Rica. Entrance surface air kerma (ESAK) and the scatter dose values were measured on phantoms of 4-20 cm thicknesses of polymethyl methacrylate slabs. Image quality was evaluated using DICOM images of a test object Leeds TOR 18-FG, through the numerical parameters signal-to-noise ratio (SNR), high-contrast spatial resolution (HCSR) and figure of merit (FOM)...
March 21, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/28367790/transoral-laser-resection-or-radiotherapy-patient-choice-in-the-treatment-of-early-laryngeal-cancer-a-prospective-observational-cohort-study
#13
T Zahoor, R Dawson, M Sen, Z Makura
OBJECTIVES: The choices made by patients offered treatment for early laryngeal cancer with radiotherapy or transoral laser resection were reviewed. METHODS: A prospective review was conducted of all patients diagnosed and treated for early laryngeal carcinoma from December 2002 to September 2009 at the Leeds Teaching Hospitals NHS Trust. A total of 209 patients with tumour stage T1 or T2 laryngeal cancer were treated; each new patient suitable for radiotherapy or transoral laser resection was seen jointly by the clinical (radiation) oncologist and head and neck surgeon, and offered the choice of treatment...
April 3, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28364283/lisbon-emoji-and-emoticon-database-leed-norms-for-emoji-and-emoticons-in-seven-evaluative-dimensions
#14
David Rodrigues, Marília Prada, Rui Gaspar, Margarida V Garrido, Diniz Lopes
The use of emoticons and emoji is increasingly popular across a variety of new platforms of online communication. They have also become popular as stimulus materials in scientific research. However, the assumption that emoji/emoticon users' interpretations always correspond to the developers'/researchers' intended meanings might be misleading. This article presents subjective norms of emoji and emoticons provided by everyday users. The Lisbon Emoji and Emoticon Database (LEED) comprises 238 stimuli: 85 emoticons and 153 emoji (collected from iOS, Android, Facebook, and Emojipedia)...
March 31, 2017: Behavior Research Methods
https://www.readbyqxmd.com/read/28362129/radiofrequency-ablation-for-management-of-malignant-biliary-obstruction-a-single-center-experience-and-review-of-the-literature
#15
Amit Kumar Dutta, Umesh Basavaraju, Laura Sales, John Samuel Leeds
BACKGROUND: Radiofrequency ablation (RFA) causes coagulative necrosis of tissue and may be beneficial prior to biliary stenting. We report our experience using RFA for malignant biliary obstruction and review the literature. METHODS: Retrospective analysis of all patients undergoing RFA for malignant biliary obstruction over the last two years. Success, complications and re-intervention following RFA were assessed. Controls were age, sex and disease matched who had stenting alone...
April 7, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28361297/neuropathic-pain-in-patients-with-sickle-cell-disease-a-cross-sectional-study-assessing-teens-and-young-adults
#16
Fabricio Dias Antunes, Vynicius Goltran Sobral Propheta, Hulemar Andrade Vasconcelos, Rosana Cipolotti
Chronic pain conditions are little studied and may be underestimated in sickle cell disease (SCD). The aim of this study was to identify the occurrence and characteristics of neuropathic pain (NP) in SCD patients. A sample of 56 patients was chosen from a total of 554 patients submitted to the inclusion criteria between 2015 and 2016. The Leeds assessment of neuropathic symptoms and signs scale was used for detecting NP. The groups with and without NP were compared by sex, age, use of hydroxyurea, and sensory changes through Chi-square, Fisher's exact, ANOVA, and Kruskal-Wallis tests...
March 30, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28337329/antiparasitic-lead-discovery-toward-optimization-of-a-chemotype-with-activity-against-multiple-protozoan-parasites
#17
William Devine, Sarah M Thomas, Jessey Erath, Kelly A Bachovchin, Patricia J Lee, Susan E Leed, Ana Rodriguez, Richard J Sciotti, Kojo Mensa-Wilmot, Michael P Pollastri
Human African trypanosomiasis (HAT), Chagas disease, and leishmaniasis present a significant burden across the developing world. Existing therapeutics for these protozoal neglected tropical diseases suffer from severe side effects and toxicity. Previously, NEU-1045 (3) was identified as a promising lead with cross-pathogen activity, though it possessed poor physicochemical properties. We have designed a library of analogues with improved calculated physicochemical properties built on the quinoline scaffold of 3 incorporating small, polar aminoheterocycles in place of the 4-(3-fluorobenzyloxy)aniline substituent...
March 9, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28332827/subcellular-chemical-imaging-of-antibiotics-in-single-bacteria-using-c60-secondary-ion-mass-spectrometry
#18
Hua Tian, David A Six, Thomas Krucker, Jennifer A Leeds, Nicholas Winograd
The inherent difficulty of discovering new and effective antibacterials and the rapid development of resistance particularly in Gram-negative bacteria, illustrates the urgent need for new methods that enable rational drug design. Here we report the development of 3D imaging cluster secondary ion mass spectrometry (SIMS) as a label-free approach to chemically map small molecules in aggregated and single Escherichia coli cells, with ~300 nm spatial resolution and high chemical sensitivity. The feasibility of quantitative analysis was explored, and a non-linear relationship between treatment dose and signal for tetracycline and ampicillin, two clinically-used antibacterials, was observed...
March 23, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28330354/scanning-tunneling-microscopy-study-of-thin-ptcdi-films-on-ag-si-111-%C3%A2-3-%C3%A3-%C3%A2-3
#19
C Emanuelsson, H M Zhang, E Moons, L S O Johansson
3,4,9,10-perylene tetracarboxylic diimide molecules were evaporated onto a Ag/Si(111)-√3 × √3 surface and studied by scanning tunneling microscopy/spectroscopy and low energy electron diffraction (LEED). The growth mode was characterized as layer-by-layer growth with a single molecular unit cell in a short range order. The growth of the first two monolayers involves a molecule/substrate superstructure and a molecule/molecule superstructure. At higher coverages, the molecules in each layer were found to align so that unit cells are on top of each other...
March 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28325536/self-reported-neuropathic-pain-characteristics-of-women-with-provoked-vulvar-pain-a-preliminary-investigation
#20
Emma Dargie, Ian Gilron, Caroline F Pukall
BACKGROUND: Provoked vestibulodynia (PVD) is a common chronic genital pain condition affecting approximately 12% of premenopausal women. Although parallels have been drawn between PVD and neuropathic pain (NP), no studies have examined self-reported NP characteristics in PVD. AIM: To explore pain symptoms that resemble NP reported by those with PVD and compare responses with those with an established NP condition. METHODS: Women with provoked vulvar pain (PVP; n = 65) completed online questionnaires designed to assess characteristics of NP...
April 2017: Journal of Sexual Medicine
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