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diabetic foot ulcer

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https://www.readbyqxmd.com/read/29220878/a-qualitative-study-of-the-experience-of-lower-extremity-wounds-and-amputations-among-people-with-diabetes-in-philadelphia
#1
Frances K Barg, Peter F Cronholm, Ebony E Easley, Trocon Davis, Michelle Hampton, D Scot Malay, Cornelius Donohue, Jinsup Song, Stephen R Thom, David J Margolis
The purpose of this study was to explore perceptions among people with type 2 diabetes about foot ulcers and lower extremity amputations. This was a qualitative observational study utilizing open-ended, semistructured interviews of 39 people with diabetes who were purposively selected because they had either a foot ulcer (n = 19) or a lower extremity amputation (n = 20). Interviews were audio-recorded, deidentified, and entered into NVivo 10.0 for coding and analysis. Our integrated analytic approach combined inductively and deductively derived codes that were applied to all transcripts...
December 8, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29214854/prognostic-factors-in-diabetic-foot-ulcer
#2
Funda Sungur Biteker, Bülent Özlek, Eda Özlek, Murat Biteker
No abstract text is available yet for this article.
January 1, 2017: Angiology
https://www.readbyqxmd.com/read/29204271/genome-sequencing-and-analysis-of-the-first-spontaneous-nanosilver-resistant-bacterium-proteus-mirabilis-strain-scdr1
#3
Amr T M Saeb, Khalid A Al-Rubeaan, Mohamed Abouelhoda, Manojkumar Selvaraju, Hamsa T Tayeb
Background: P. mirabilis is a common uropathogenic bacterium that can cause major complications in patients with long-standing indwelling catheters or patients with urinary tract anomalies. In addition, P. mirabilis is a common cause of chronic osteomyelitis in Diabetic foot ulcer (DFU) patients. We isolated P. mirabilis SCDR1 from a Diabetic ulcer patient. We examined P. mirabilis SCDR1 levels of resistance against Nanosilver colloids, the commercial Nanosilver and silver containing bandages and commonly used antibiotics...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29203426/effects-of-structurally-stabilized-egf-and-bfgf-on-wound-healing-in-type-i-and-type-ii-diabetic-mice
#4
Seong Mi Choi, Kyoung-Mi Lee, Hyun Jung Kim, Ik Kyu Park, Hwi Ju Kang, Hang-Cheol Shin, Dawoon Baek, Yoorim Choi, Kwang Hwan Park, Jin Woo Lee
Diabetes mellitus comprises a multiple metabolic disorder that affects millions of people worldwide and consequentially poses challenges for clinical treatment. Among the various complications, diabetic ulcer constitutes the most prevalent associated disorder and leads to delayed wound healing. To enhance wound healing capacity, we developed structurally stabilized epidermal growth factor (ST-EGF) and basic fibroblast growth factor (ST-bFGF) to overcome limitations of commercially available EGF (CA-EGF) and bFGF (CA-bFGF), such as short half-life and loss of activity after loading onto a matrix...
December 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29202978/evidence-based-review-of-literature-on-detriments-to-healing-of-diabetic-foot-ulcers
#5
REVIEW
Tina Lefrancois, Kinjal Mehta, Victoria Sullivan, Sheldon Lin, Mark Glazebrook
BACKGROUND: Diabetes mellitus places a substantial burden on society worldwide. Diabetic foot ulcers are a challenging problem for clinicians. Seven generally accepted detriments to healing of diabetic foot ulcers were identified: infection, glycaemic control, vascular supply, smoking, nutrition, deformity and offloading. The aim of this paper is to present a comprehensive evidence based review of the literature available on detriments to healing of diabetic foot ulcers. METHOD: A research question was generated for each of the detriments to healing and a comprehensive review of the literature was performed using the Pubmed database in July 2014...
December 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29201882/remote-home-monitoring-to-identify-and-prevent-diabetic-foot-ulceration
#6
EDITORIAL
P Andrew Crisologo, Lawrence A Lavery
No abstract text is available yet for this article.
November 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29201147/evidence-for-current-recommendations-concerning-the-management-of-foot-health-for-people-with-chronic-long-term-conditions-a-systematic-review
#7
Katherine Edwards, Alan Borthwick, Louise McCulloch, Anthony Redmond, Rafael Pinedo-Villanueva, Daniel Prieto-Alhambra, Andrew Judge, Nigel Arden, Catherine Bowen
Background: Research focusing on management of foot health has become more evident over the past decade, especially related to chronic conditions such as diabetes. The level of methodological rigour across this body of work however is varied and outputs do not appear to have been developed or translated into clinical practice. The aim of this systematic review was to assess the latest guidelines, standards of care and current recommendations relative to people with chronic conditions to ascertain the level of supporting evidence concerning the management of foot health...
2017: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/29201075/development-and-evaluation-of-patient-information-leaflet-for-diabetic-foot-ulcer-patients
#8
Sonal Sekhar M, Unnikrishnan Mk, Navya Vyas, Gabriel Sunil Rodrigues
Background: Patient education (PE) is as important as medical and surgical interventions in the management of diabetic foot ulcer (DFU). Patient information leaflets (PILs) are globally accepted patient counseling aids. Objectives: This study aimed at developing PILs for DFU patients and investigating its validation. Methods: The PILs were prepared based on different model leaflets available from various online resources, including "Patient UK"...
July 2017: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29193662/the-effects-of-probiotic-administration-on-wound-healing-and-metabolic-status-in-patients-with-diabetic-foot-ulcer-a-randomized-double-blind-placebo-controlled-trial
#9
Sima Mohseni, Masomeh Bayani, Fereshteh Bahmani, Maryam Tajabadi-Ebrahimi, Mohammad Ali Bayani, Parvaneh Jafari, Zatollah Asemi
BACKGROUND: This study was conducted to evaluate the effects of probiotic supplementation on wound healing and metabolic status in subjects with diabetic foot ulcer (DFU). METHODS: This randomized, double-blind, placebo-controlled trial was conducted among 60 subjects (aged 40-85 years old) with grade 3 DFU. Individuals were randomly divided into two groups (30 subjects each group) to receive either probiotic or placebo daily for 12 weeks. RESULTS: After the 12-week intervention, compared with the placebo, probiotic supplementation led to significant reductions in ulcer length (-1...
November 28, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29193527/telemedicine-follow-up-facilitates-more-comprehensive-diabetes-foot-ulcer-care-a-qualitative-study-in-home-based-and-specialist-health-care
#10
Beate-Christin Hope Kolltveit, Sally Thorne, Marit Graue, Eva Gjengedal, Marjolein M Iversen, Marit Kirkevold
AIMS AND OBJECTIVES: To investigate the application of a telemedicine intervention in diabetes foot ulcer care, and its implications for the health care professionals in the clinical field. BACKGROUND: Contextual factors are found to be important when applying technology in health care and applying telemedicine in home-based care has been identified as particularly complex. DESIGN AND METHODS: We conducted field observations and individual interviews among health care professionals in home-based care and specialist health care in a diabetes foot care telemedicine RCT (Clin...
November 29, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29188676/autologous-lipotransfer-versus-stromal-vascular-fraction-enriched-lipoinjection-for-diabetic-foot-wounds-healing-a-pilot-study
#11
G Vicenti, G Solarino, V Pesce, L Moretti, A Notarnicola, M Carrozzo, F Rifino, B Moretti
Chronic ulcers of the lower limbs represent a significant social and economic burden. Diabetes is a strong risk factor for development of chronic lesions. Adult stem cells and growth factors derived from the adipose tissue are among the most promising therapeutic strategies for hard to heal wounds. Fat grafts have been used for several decades to treat soft tissue deformities, but despite its excellent characteristics, the outcome was unpredictable, due to partial necrosis and resorption of the graft. Stem cells’ enrichment of these grafts or their injection into the edges of the ulcers have shown encouraging results in various experimental settings...
October 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29187423/the-effect-of-telemedicine-follow-up-care-on-diabetes-related-foot-ulcers-a-cluster-randomized-controlled-noninferiority-trial
#12
Hilde Smith-Strøm, Jannicke Igland, Truls Østbye, Grethe S Tell, Marie F Hausken, Marit Graue, Svein Skeie, John G Cooper, Marjolein M Iversen
OBJECTIVE: To evaluate whether telemedicine (TM) follow-up of patients with diabetes-related foot ulcers (DFUs) in primary health care in collaboration with specialist health care was noninferior to standard outpatient care (SOC) for ulcer healing time. Further, we sought to evaluate whether the proportion of amputations, deaths, number of consultations per month, and patient satisfaction differed between the two groups. RESEARCH DESIGN AND METHODS: Patients with DFUs were recruited from three clinical sites in western Norway (2012-2016)...
November 29, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29184753/tissue-augmentation-with-allograft-adipose-matrix-for-the-diabetic-foot-in-remission
#13
Tala B Shahin, Kairavi V Vaishnav, Marcy Watchman, Vignesh Subbian, Ethan Larson, Evangelia Chnari, David G Armstrong
Background: Repetitive stress on the neuropathic plantar foot is the primary cause of diabetic foot ulcers. After healing, recurrence is common. Modulating plantar pressure has been associated with extension of ulcer free days. Therefore, the goal of this study was to determine the effects of an injectable allograft adipose matrix in providing a protective padding and reducing the pressure in the plantar foot. Methods: After healing his recurrent ulcer using total contact casting, a 71-year-old man with a 9-year history of recurrent diabetic foot ulcers was treated with injection of allograft adipose matrix, procured from donated human tissue...
October 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29176889/all-cause-mortality-among-diabetic-foot-patients-and-related-risk-factors-in-saudi-arabia
#14
Khalid Al-Rubeaan, Mohammad K Almashouq, Amira M Youssef, Hamid Al-Qumaidi, Mohammad Al Derwish, Samir Ouizi, Khalid Al-Shehri, Saba N Masoodi
BACKGROUND: Although Diabetes mellitus is a major public health problem in the Middle East and North Africa (MENA) region with high rates of diabetic foot complications, there are only limited data concerning mortality among such a high risk group. Therefore, the main aim of the current study was to assess all-cause mortality and its related predictors among diabetic patients with and without diabetic foot complications. METHODS: Using data from the Saudi National Diabetes Registry (SNDR), a total of 840 patients with type 1 or type 2 diabetes aged ≥25 years with current or past history of diabetic foot ulcer (DFU) or diabetes related lower extremity amputation (LEA) were recruited in 2007 from active patients' files and followed up to 2013...
2017: PloS One
https://www.readbyqxmd.com/read/29168418/telemedicine-in-diabetic-foot-care-a-systematic-literature-review-of-interventions-and-meta-analysis-of-controlled-trials
#15
Huidi Tchero, Lazarre Noubou, Beatrice Becsangele, Martin Mukisi-Mukaza, Gerald-Reparate Retali, Emmanuel Rusch
The care of individuals with diabetic foot ulcers is costly and requires multiple hospital visits. Inadequate care leads to serious complications and a high risk of lower extremity amputation. In this review, we aimed at evaluating whether telemedicine can be effective in diabetic foot patient care. We searched Medline through Embase and PubMed and Cochrane Central Register of Controlled Trials (CENTRAL) for relevant studies, published up to April 2017. The studies were summarized and discussed in a narrative method and a meta-analysis of 2 controlled trials was conducted using the fixed-effects model...
November 1, 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/29165561/evaluation-of-short-exposure-times-of-antimicrobial-wound-solutions-against-microbial-biofilms-from-in-vitro-to-in-vivo
#16
K Johani, M Malone, S O Jensen, H G Dickson, I B Gosbell, H Hu, Q Yang, G Schultz, K Vickery
Objectives: Test the performance of topical antimicrobial wound solutions against microbial biofilms using in vitro, ex vivo and in vivo model systems at clinically relevant exposure times. Methods: Topical antimicrobial wound solutions were tested under three different conditions: (in vitro) 4% w/v Melaleuca oil, polyhexamethylene biguanide, chlorhexidine, povidone iodine and hypochlorous acid were tested at short duration exposure times for 15 min against 3 day mature biofilms of Staphylococcus aureus and Pseudomonas aeruginosa; (ex vivo) hypochlorous acid was tested in a porcine skin explant model with 12 cycles of 10 min exposure, over 24 h, against 3 day mature P...
November 18, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29164152/foot-complications-in-a-representative-australian-inpatient-population
#17
Peter A Lazzarini, Sheree E Hurn, Suzanne S Kuys, Maarten C Kamp, Vanessa Ng, Courtney Thomas, Scott Jen, Jude Wills, Ewan M Kinnear, Michael C d'Emden, Lloyd F Reed
We investigated the prevalence and factors independently associated with foot complications in a representative inpatient population (adults admitted for any reason with and without diabetes). We analysed data from the Foot disease in inpatients study, a sample of 733 representative inpatients. Previous amputation, previous foot ulceration, peripheral arterial disease (PAD), peripheral neuropathy (PN), and foot deformity were the foot complications assessed. Sociodemographic, medical, and foot treatment history were collected...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29161945/identification-of-an-ndm-1-producing-klebsiella-pneumoniae-from-diabetic-foot-ulcer-in-china
#18
Shuai Ye, Li Ni, Sihu Wang, Wu Dai
No abstract text is available yet for this article.
November 22, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/29158856/intralesional-administration-of-human-recombinant-epidermal-growth-factor-improves-healing-and-reduces-amputations-in-patients-with-severe-diabetic-foot-ulcers
#19
Aristides L Garcia Herrera
No abstract text is available yet for this article.
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/29158852/curative-metatarsal-bone-surgery-combined-with-intralesional-administration-of-recombinant-human-epidermal-growth-factor-in-diabetic-neuropathic-ulceration-of-the-forefoot-a-prospective-open-uncontrolled-nonrandomized-observational-study
#20
Aristides L Garcia Herrera, Ridel de Jesús Febles Sanabria, Liliana de Los Ángeles Acosta Cabadilla, Miriam Moliner Cartaya
Background: Curative surgery is performed for a foot with ulcers and loss of protective sensation to heal the wound and prevent amputation. Evidence supports that patients with diabetes have decreased concentrations of growth factors in their tissues, notably epidermal growth factor (EGF). Injecting EGF deep into the bottom of the wound and its contours encourages a more effective response in terms of granulation tissue growth and wound closure. Objective: To assess the effectiveness and safety of curative metatarsal bone surgery combined with intralesional administration of human recombitant EGF in neuropathic diabetic forefoot ulceration...
2017: Current Therapeutic Research, Clinical and Experimental
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