keyword
https://read.qxmd.com/read/38497521/second-metatarsal-length-and-transfer-ulcers-after-first-metatarsal-amputation-in-diabetic-foot-infections
#1
JOURNAL ARTICLE
Nicola A Cavalcanti, Katharina Martini, Tobias Götschi, Nicola Krähenbühl, Madlaina Schöni, Felix W A Waibel
BACKGROUND: Plantar transfer ulcers (TUs) underneath the second metatarsal head are frequent after first metatarsal ray amputations due to diabetic foot infections. Whether the second metatarsal length (2ML) is associated with TU occurrence in these patients is unclear. This study evaluated whether 2ML is associated with TU occurrence after first-ray amputations and whether ulcer-free survival is shorter in patients with "excess" 2ML. METHODS: Forty-two patients with a mean age of 67 (range 33-93) years, diabetes, and first metatarsal ray amputation (first amputation at the affected foot) were included...
March 18, 2024: Foot & Ankle International
https://read.qxmd.com/read/38496839/bibliometric-analysis-of-systematic-review-and-meta-analysis-on-diabetic-foot-ulcer
#2
JOURNAL ARTICLE
Yanyan Wang, Cong Wang, Lei Zheng
Many clinical management strategies have been proposed to deal with diabetic foot ulcers. However, the occurrence and recurrence of foot ulcers remain the major problems for diabetics. This study aims to identify, visualize, and characterize the meta-analyses on diabetic foot ulcer research. Articles published online were retrieved from the Web of Science core collection database using a search query incorporating MeSH terms and topics related to diabetic foot ulcers and meta-analysis. The publications were then analyzed for basic characteristics, including publication year, countries, topics covered, references, and keywords discussed in the articles...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38494793/the-effect-of-vegf-stimulation-in-diabetic-foot-ulcers-a-systematic-review
#3
REVIEW
Frederik S Bang, Veronica Leeberg, Ming Ding, Chris H Dreyer
Diabetic foot ulcers are a common and severe complication of diabetes mellitus, and a risk factor for amputation. Because of the vessel insufficiency in diabetic foot ulcers (DFU), vascular endothelial growth factor (VEGF) that simulates angiogenesis is of interest to promote wound healing. This systematic review evaluates the last 16 years of in-vivo studies with VEGF stimulation as a treatment for DFU, developed based on the last published systematic article. A total of 961 articles were identified through databases in two phases...
March 17, 2024: Wound Repair and Regeneration
https://read.qxmd.com/read/38489054/offloading-systems-for-the-treatment-of-neuropathic-foot-ulcers-in-patients-with-diabetes-mellitus-a-meta-analysis-of-randomized-controlled-trials-for-the-development-of-the-italian-guidelines-for-the-treatment-of-diabetic-foot-syndrome
#4
REVIEW
Carlotta Gauna, Francesco Romeo, Alessia Scatena, Cesare Miranda, Luigi Uccioli, Cristiana Vermigli, Antonio Volpe, Corrado Bordieri, Rodolfo Tramonta, Benedetta Ragghianti, Giulia Bandini, Matteo Monami, Luca Monge
AIM: To compare the effectiveness of commonly used offloading devices for the treatment of neuropathic foot ulcers in patients with diabetes mellitus. This meta-analysis (MA) has been performed for giving an answer to clinical questions on this topic of the Italian guideline on diabetic foot syndrome. METHODS: The present MA includes randomized controlled studies (duration > 12 weeks) comparing, in patients with diabetes mellitus and non-infected neuropathic foot ulcer: any offloading device vs either no offloading device or conventional footwear; removable versus non-removable offloading devices; surgical procedure vs other offloading approaches...
March 15, 2024: Acta Diabetologica
https://read.qxmd.com/read/38484403/retraction-thoughts-and-experiences-regarding-leg-amputation-among-patients-with-diabetic-foot-ulcers-a-phenomenological-study
#5
(no author information available yet)
No abstract text is available yet for this article.
March 2024: International Wound Journal
https://read.qxmd.com/read/38482321/micronutrient-status-in-patients-with-diabetic-foot-ulcers-a-cross-sectional-study-in-saudi-arabia
#6
JOURNAL ARTICLE
Mutasem Ababneh, Mousab Y Al Ayed, Asirvatham A Robert, Maysa Amer, Raeed A Al Rashidi, Faisal Al Mansour, Abdulghani Al Saeed, Mohamed A Al Dawish
BACKGROUND: Patients with diabetes are at risk for developing diabetic foot ulcers (DFUs). It is recognized that type 2 diabetes (T2D) is distinguished by the loss of vitally important micronutrients because of the metabolic nature of this disease and its associated complexities. OBJECTIVE: This study was performed to determine the level of micronutrients in patients with DFUs in Saudi Arabia. From February to May 2022, this descriptive study was conducted, adopting the cross-sectional design and a group of 88 patients with T2D...
January 2024: Journal of Family Medicine and Primary Care
https://read.qxmd.com/read/38479430/misdiagnosis-of-cutaneous-epithelioid-angiosarcoma-as-diabetic-foot-ulcer-a-case-study
#7
JOURNAL ARTICLE
Yousef Almheirat, Lamis Elyamani, Ouissal Hormi, Nassiba Zerrouki, Nada Zizi, S Dikhaye
BACKGROUND: AS is a malignant tumor that originates from vascular endothelial cells and is known for a high rate of local recurrence and metastasis. CASE REPORT: A 48-year-old male presented with cutaneous epithelioid AS. Cutaneous AS of the foot is quite rare, especially in the absence of predisposing factors, and in this patient it was previously misdiagnosed as a DFU. CONCLUSION: Physicians should be aware of this rare presentation of cutaneous AS...
February 2024: Wounds: a Compendium of Clinical Research and Practice
https://read.qxmd.com/read/38477463/improving-diabetic-wound-healing-outcomes-with-topical-growth-factor-therapies-systematic-review-and-network-meta-analysis-of-randomised-controlled-trials
#8
JOURNAL ARTICLE
Andrew Yew Wei Wong, Natalie Ming Foong Hooi, Brian Sheng Yep Yeo, Rehena Sultana, Yong Mong Bee, Ainsley Ryan Yan Bin Lee, Sook Muay Tay
CONTEXT: Diabetes mellitus is associated with morbid complications such as diabetic foot ulcers (DFUs) that may lead to amputations or mortality if not managed adequately. OBJECTIVE: New adjunctive interventions to treat diabetic wounds include topical biologics and growth factors. This study aims to evaluate their efficacy in improving wound healing outcomes and safety. DATA SOURCES: Comprehensive database searches of MEDLINE via PubMed, EMBASE and Cochrane performed from inception to December 2022...
March 13, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38476441/can-acupuncture-increase-microcirculation-in-peripheral-artery-disease-and-diabetic-foot-syndrome-a-pilot-study
#9
JOURNAL ARTICLE
Jan Valentini, Martin Sigl, Cornelia Dunckel, Johannes Krisam, Klaus Amendt, Henry Johannes Greten
BACKGROUND: Globally, diabetes mellitus (DM) and peripheral artery disease (PAD) have an increasing incidence and a high prevalence and are both associated with high morbidity and complication rates, e.g., as chronic non-healing peripheral ulcers. Impaired macro- and microcirculation and peripheral neuropathy lead to an increased risk of foot ulcers and infections. These complications are difficult to treat, have a high risk of becoming chronic and often lead to lower limb amputation...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38474419/lncrna-neat1-mir-146a-5p-axis-restores-normal-angiogenesis-in-diabetic-foot-ulcers-by-targeting-mafg
#10
JOURNAL ARTICLE
Tca Architha, George Raj Juanitaa, Ramanarayanan Vijayalalitha, Ravichandran Jayasuriya, Gopinathan Athira, Ramachandran Balamurugan, Kumar Ganesan, Kunka Mohanram Ramkumar
Non-healing lesions in diabetic foot ulcers are a significant effect of poor angiogenesis. Epigenetic regulators, mainly lncRNA and miRNA, are recognized for their important roles in disease progression. We deciphered the regulation of lncRNA NEAT1 through the miR-146a-5p/mafG axis in the progression of DFU. A lowered expression of lncRNA NEAT1 was associated with dysregulated angiogenesis through the reduced expression of mafG , SDF-1α , and VEGF in chronic ulcer subjects compared to acute DFU. This was validated by silencing NEAT1 by SiRNA in the endothelial cells which resulted in the transcriptional repression of target genes...
March 5, 2024: Cells
https://read.qxmd.com/read/38474378/the-combination-of-vascular-endothelial-growth-factor-a-vegf-a-and-fibroblast-growth-factor-1-fgf1-modified-mrna-improves-wound-healing-in-diabetic-mice-an-ex-vivo-and-in-vivo-investigation
#11
JOURNAL ARTICLE
Sandra Tejedor, Maria Wågberg, Cláudia Correia, Karin Åvall, Mikko Hölttä, Leif Hultin, Michael Lerche, Nigel Davies, Nils Bergenhem, Arjan Snijder, Tom Marlow, Pierre Dönnes, Regina Fritsche-Danielson, Jane Synnergren, Karin Jennbacken, Kenny Hansson
BACKGROUND: Diabetic foot ulcers (DFU) pose a significant health risk in diabetic patients, with insufficient revascularization during wound healing being the primary cause. This study aimed to assess microvessel sprouting and wound healing capabilities using vascular endothelial growth factor (VEGF-A) and a modified fibroblast growth factor (FGF1). METHODS: An ex vivo aortic ring rodent model and an in vivo wound healing model in diabetic mice were employed to evaluate the microvessel sprouting and wound healing capabilities of VEGF-A and a modified FGF1 both as monotherapies and in combination...
February 27, 2024: Cells
https://read.qxmd.com/read/38472627/the-implication-of-diabetes-specialized-nurses-in-aiming-for-the-better-treatment-and-management-of-patients-with-diabetes-mellitus-a-brief-narrative-review
#12
REVIEW
Yefang Zhu, Hongmei Zhang, Ying Xi, Hongli Zhu, Yan Lu, Xue Luo, Zhangui Tang, Hong Lei
Diabetes mellitus (DM) is regarded as one of the most critical public health challenges of the 21st century. It has evolved into a burgeoning epidemic since the last century, and today ranks among the major causes of mortality worldwide. Diabetes specialist nurses (DSNs) are central to good patient care and outcomes including confident self-care management. Evidence shows that DSNs are cost-effective, improve clinical outcomes, and reduce length of stay in hospital. In this brief narrative review, we aim to describe the roles of DSNs and their contribution in the treatment and management of patients with DM...
March 12, 2024: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/38470420/liraglutide-for-lower-limb-perfusion-in-people-with-type-2-diabetes-and-peripheral-artery-disease-the-stardust-randomized-clinical-trial
#13
RANDOMIZED CONTROLLED TRIAL
Paola Caruso, Maria Ida Maiorino, Miriam Longo, Chiara Porcellini, Rita Matrone, Lucia Digitale Selvaggio, Maurizio Gicchino, Carla Carbone, Lorenzo Scappaticcio, Giuseppe Bellastella, Dario Giugliano, Katherine Esposito
IMPORTANCE: Peripheral artery disease (PAD) in diabetes may lead to diabetic foot ulcer and lower-extremities amputation. Glucagon-like peptide 1 receptor agonists have proven cardiovascular benefits in trials of people with type 2 diabetes at high cardiovascular risk. OBJECTIVE: To examine the effect of liraglutide on peripheral perfusion measured as peripheral transcutaneous oxygen pressure (TcPo2) in individuals with type 2 diabetes and PAD. DESIGN, SETTING, AND PARTICIPANTS: This open-label randomized clinical trial was conducted between February 1, 2021, and June 30, 2022, with a final follow-up on December 30, 2022, at University of Campania "Luigi Vanvitelli," Naples, Italy...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38468410/hmox1-as-a-therapeutic-target-associated-with-diabetic-foot-ulcers-based-on-single-cell-analysis-and-machine-learning
#14
JOURNAL ARTICLE
Yiqi Chen, Yixin Zhang, Ming Jiang, Hong Ma, Yuhui Cai
Diabetic foot ulcers (DFUs) are a serious chronic complication of diabetes mellitus and a leading cause of disability and death in diabetic patients. However, current treatments remain unsatisfactory. Although macrophages are associated with DFU, their exact role in this disease remains uncertain. This study sought to detect macrophage-related genes in DFU and identify possible therapeutic targets. Single-cell datasets (GSE223964) and RNA-seq datasets (GSM68183, GSE80178, GSE134431 and GSE147890) associated with DFU were retrieved from the gene expression omnibus (GEO) database for this study...
March 2024: International Wound Journal
https://read.qxmd.com/read/38465784/hydrogel-dressings-for-diabetic-foot-ulcer-a-systematic-review-and-meta-analysis
#15
JOURNAL ARTICLE
Hongjiao Zhao, You Wu, Yuchen Xie, Yanfei Li, Chen Chen, Chanjuan Li, Fangzheng Yang, Deteng Zhang, Yaqin Wang, Junhua Yuan
AIM: To investigate the differences in utility between conventional dressings and hydrogel dressings for the treatment of diabetic foot ulcer (DFU). METHODS: The PubMed, Embase, Cochrane Library, CNKI, VIP and Wanfang databases were systematically searched up to 21 January 2023. Fixed/random-effect models were used to calculate the odds ratios (ORs) and mean differences (MDs) with 95% confidence intervals (CIs) for the effect size analysis, with heterogeneity determined by I2 statistics...
March 11, 2024: Diabetes, Obesity & Metabolism
https://read.qxmd.com/read/38465347/association-between-metabolic-dysfunction-associated-fatty-liver-disease-and-macces-in-patients-with-diabetic-foot-ulcers-an-ambispective-longitudinal-cohort-study
#16
JOURNAL ARTICLE
Xiuxian Huang, Zhengming Li, Zhenwei Zhai, Qiu Wang, Rongyan Wei, Jiacheng Mo, Jianhao Huang, Wensheng Lu
AIM: Metabolic dysfunction-related fatty liver disease (MAFLD) is closely related to metabolic disorders. However, the relationship between MAFLD and the prognosis in diabetic foot ulcers (DFUs) remains unclear. This study aimed to explore the association between MAFLD and the risk of major adverse cardiac and cerebral events (MACCEs) in patients with DFUs. METHODS: 889 inpatients with DFUs (PEDIS/TEXAS mild and above) were included in this study from 2013 to 2023...
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38464666/research-progress-on-and-molecular-mechanism-of-vacuum-sealing-drainage-in-the-treatment-of-diabetic-foot-ulcers
#17
REVIEW
Yongpan Lu, Dejie Zhao, Guoqi Cao, Siyuan Yin, Chunyan Liu, Ru Song, Jiaxu Ma, Rui Sun, Zhenjie Wu, Jian Liu, Peng Wu, Yibing Wang
Diabetic foot ulcers (DFUs) are common chronic wounds and a common complication of diabetes. The foot is the main site of diabetic ulcers, which involve small and medium-sized arteries, peripheral nerves, and microcirculation, among others. DFUs are prone to coinfections and affect many diabetic patients. In recent years, interdisciplinary research combining medicine and material science has been increasing and has achieved significant clinical therapeutic effects, and the application of vacuum sealing drainage (VSD) in the treatment of DFUs is a typical representative of this progress, but the mechanism of action remains unclear...
2024: Frontiers in Surgery
https://read.qxmd.com/read/38463193/the-mechanism-of-pyroptosis-and-its-application-prospect-in-diabetic-wound-healing
#18
REVIEW
Abdullah Al Mamun, Chuxiao Shao, Peiwu Geng, Shuanghu Wang, Jian Xiao
Pyroptosis defines a form of pro-inflammatory-dependent programmed cell death triggered by gasdermin proteins, which creates cytoplasmic pores and promotes the activation and accumulation of immune cells by releasing several pro-inflammatory mediators and immunogenic substances upon cell rupture. Pyroptosis comprises canonical (mediated by Caspase-1) and non-canonical (mediated by Caspase-4/5/11) molecular signaling pathways. Numerous studies have explored the contributory roles of inflammasome and pyroptosis in the progression of multiple pathological conditions such as tumors, nerve injury, inflammatory diseases and metabolic disorders...
2024: Journal of Inflammation Research
https://read.qxmd.com/read/38461443/effect-of-a-multidisciplinary-team-approach-in-patients-with-diabetic-foot-ulcers-on-major-adverse-limb-events-males-systematic-review-and-meta-analysis-for-the-development-of-the-italian-guidelines-for-the-treatment-of-diabetic-foot-syndrome
#19
REVIEW
Marco Meloni, Laura Giurato, Luca Monge, Cesare Miranda, Alessia Scatena, Benedetta Ragghianti, Giovanni Antonio Silverii, Cristiana Vermigli, Alessandro De Cassai, Antonio Volpe, Rodolfo Tramonta, Gerardo Medea, Corrado Bordieri, Marco Falcone, Laura Stefanon, Andrea Bernetti, Cristina Cappella, Mauro Gargiulo, Valentina Lorenzoni, Germano Scevola, Eugenio Stabile, Roberto Da Ros, Giuseppe Murdolo, Eleonora Bianchini, Francesco Gaggia, Carlotta Gauna, Francesco Romeo, Matteo Apicella, Michele Mantuano, Matteo Monami, Luigi Uccioli
The treatment of patients with diabetic foot ulcers (DFUs) is extremely complex, requiring a comprehensive approach that involves a variety of different healthcare professionals. Several studies have shown that a multidisciplinary team (MDT) approach is useful to achieve good clinical outcomes, reducing major and minor amputation and increasing the chance of healing. Despite this, the multidisciplinary approach is not always a recognized treatment strategy. The aim of this meta-analysis was to assess the effects of an MDT approach on major adverse limb events, healing, time-to-heal, all-cause mortality, and other clinical outcomes in patients with active DFUs...
March 10, 2024: Acta Diabetologica
https://read.qxmd.com/read/38461326/microrna-221-3p-inhibits-the-inflammatory-response-of-keratinocytes-by-regulating-the-dyrk1a-stat3-signaling-pathway-to-promote-wound-healing-in-diabetes
#20
JOURNAL ARTICLE
Keyan Hu, Lei Liu, Songtao Tang, Xin Zhang, Hongfeng Chang, Wenyang Chen, Taotao Fan, Lesha Zhang, Bing Shen, Qiu Zhang
Diabetic foot ulcer (DFU), a serious complication of diabetes, remains a clinical challenge. MicroRNAs affect inflammation and may have therapeutic value in DFU. Here, we find that an miR-221-3p mimic reduces the inflammatory response and increases skin wound healing rates in a mouse model of diabetes, whereas miR-221-3p knockout produced the opposite result. In human keratinocytes cells, miR-221-3p suppresses the inflammatory response induced by high glucose. The gene encoding DYRK1A is a target of miR-221-3p...
March 9, 2024: Communications Biology
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