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https://www.readbyqxmd.com/read/29032404/dietary-supplementation-with-methylseleninic-acid-inhibits-mammary-tumorigenesis-and-metastasis-in-male-mmtv-pymt-mice
#1
Sneha Sundaram, Lin Yan
Male breast cancer, which makes up approximately 1% of all breast cancers, is an aggressive disease with poor prognosis. We investigated the effects of dietary supplementation with selenium in the form of methylseleninic acid [(MSeA) 2.5 mg selenium/kg] on mammary tumorigenesis in male MMTV-PyMT mice. The mammary tumor latency was 14.6 weeks for the MSeA-fed group and 13.8 weeks for the controls fed the AIN93G diet (p < 0.05). Dietary supplementation with MSeA, versus the control, resulted in a 72% reduction in tumor progression, a 46% reduction in both final volume and weight of mammary tumors, and a 70% reduction in the number of lung metastases...
October 14, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28974461/bone-replaces-articular-cartilage-in-the-rat-knee-joint-after-prolonged-immobilization
#2
T M Campbell, K Reilly, O Laneuville, H Uhthoff, G Trudel
BACKGROUND: Lost joint range of motion (ROM) is common in chronic osteoarthritis, alters regional weight-bearing across the articular surfaces, and contributes to loss of cartilage and bone alterations. Limited data exist on the regional effects on joints subjected to chronic losses of ROM. OBJECTIVE: To characterize the regional replacement by bone as part of articular cartilage degeneration after prolonged immobilization. METHODS: Eleven rat knees were rigidly-immobilized in flexion for 32weeks with contralateral and sham-operated (n=6) knees as controls...
September 30, 2017: Bone
https://www.readbyqxmd.com/read/28954573/are-varus-knees-contracted-reconciling-the-literature
#3
Michael J McAuliffe, Ali Vakili, Gautam Garg, John Roe, Sarah L Whitehouse, Ross Crawford
PURPOSE: There is direct literature conflict regarding coronal plane contracture or laxity in the end-stage varus osteoarthritic knee. Understanding the preoperative soft tissue status is important for optimizing the soft tissue envelope during total knee arthroplasty (TKA). METHODS: The lower limb was manipulated using computer navigation, prior to surgical releases, to allow the limb weight-bearing axis to pass through the knee centre in maximum extension and 20° of flexion...
September 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28837057/the-natural-fungal-metabolite-beauvericin-exerts-anticancer-activity-in-vivo-a-pre-clinical-pilot-study
#4
Daniela Heilos, Yelko Rodríguez-Carrasco, Bernhard Englinger, Gerald Timelthaler, Sushilla van Schoonhoven, Michael Sulyok, Simon Boecker, Roderich D Süssmuth, Petra Heffeter, Rosa Lemmens-Gruber, Rita Dornetshuber-Fleiss, Walter Berger
Recently, in vitro anti-cancer properties of beauvericin, a fungal metabolite were shown in various cancer cell lines. In this study, we assessed the specificity of this effect by comparing beauvericin cytotoxicity in malignant versus non-malignant cells. Moreover, we tested in vivo anticancer effects of beauvericin by treating BALB/c and CB-17/SCID mice bearing murine CT-26 or human KB-3-1-grafted tumors, respectively. Tumor size and weight were measured and histological sections were evaluated by Ki-67 and H/E staining as well as TdT-mediated-dUTP-nick-end (TUNEL) labeling...
August 24, 2017: Toxins
https://www.readbyqxmd.com/read/28815275/similar-failure-rate-in-immediate-post-operative-weight-bearing-versus-protected-weight-bearing-following-meniscal-repair-on-peripheral-vertical-meniscal-tears
#5
Bryan Perkins, Kyle R Gronbeck, Ruixian Alexander Yue, Marc A Tompkins
PURPOSE AND HYPOTHESIS: Post-operative weight bearing after meniscal repair is a point of debate among physicians. This study sought to evaluate whether patients adhering to an immediate WBAT rehabilitation programme have a higher failure rate compared to those adhering to a more traditional, protected, NWB status following meniscal repair. The null hypothesis was that there would be no difference in failure between the two groups. METHODS: A retrospective review of meniscal repair patients greater than 5 years from surgery was performed for patients receiving meniscal repair treatment...
August 16, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28574851/crgd-installed-docetaxel-loaded-mertansine-prodrug-micelles-redox-triggered-ratiometric-dual-drug-release-and-targeted-synergistic-treatment-of-b16f10-melanoma
#6
Ping Zhong, Min Qiu, Jian Zhang, Huanli Sun, Ru Cheng, Chao Deng, Fenghua Meng, Zhiyuan Zhong
The combinatorial chemotherapy that has emerged as a promising treatment modality for intractable cancers is challenged by lack of tumor-targeting, robust and ratiometric dual drug release systems. Here, docetaxel-loaded cRGD peptide-decorated redox-activable micellar mertansine prodrug (DTX-cRGD-MMP) was developed for targeted and synergistic treatment of B16F10 melanoma-bearing C57BL/6 mice. DTX-cRGD-MMP exhibited a small size of ca. 49 nm, high DTX and DM1 loading, low drug leakage under physiological conditions, while rapid release of both DTX and DM1 under a cytoplasmic reductive environment...
June 2, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28570014/metronomic-treatment-in-immunocompetent-preclinical-gl261-glioblastoma-effects-of-cyclophosphamide-and-temozolomide
#7
Laura Ferrer-Font, Nuria Arias-Ramos, Silvia Lope-Piedrafita, Margarida Julià-Sapé, Martí Pumarola, Carles Arús, Ana Paula Candiota
Glioblastoma (GBM) causes poor survival in patients even when applying aggressive treatment. Temozolomide (TMZ) is the standard chemotherapeutic choice for GBM treatment, but resistance always ensues. In previous years, efforts have focused on new therapeutic regimens with conventional drugs to activate immune responses that may enhance tumor regression and prevent regrowth, for example the "metronomic" approaches. In metronomic scheduling studies, cyclophosphamide (CPA) in GL261 GBM growing subcutaneously in C57BL/6 mice was shown not only to activate antitumor CD8(+) T-cell response, but also to induce long-term specific T-cell tumor memory...
September 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28515978/variation-in-medial-and-lateral-gastrocnemius-muscle-activity-with-foot-position
#8
Michael Cibulka, April Wenthe, Zach Boyle, Dylan Callier, Adam Schwerdt, Deidra Jarman, Michael J Strube
BACKGROUND: The gastrocnemius has two heads, medial gastrocnemius (MG) and lateral gastrocnemius (LG); little is known how they contract with different foot positions. The MG is more frequently strained than the LG; and gastrocnemius activation pattern altered by foot position may play a role in injury. Leg exercises often use a toe-in versus toe-out foot position to isolate one gastrocnemius head over another. PURPOSE: The purpose of this study was to determine the electromyographic gastrocnemius muscle activity in the toe-out and toe-in foot positions during weight bearing and non-weight bearing activities...
April 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/28212661/partial-versus-early-full-weight-bearing-after-uncemented-total-hip-arthroplasty-a-meta-analysis
#9
COMPARATIVE STUDY
Peng Tian, Zhi-Jun Li, Gui-Jun Xu, Xiao-Lei Sun, Xin-Long Ma
BACKGROUND: This meta-analysis aimed to investigate the efficacy and safety of partial weight bearing (PWB) versus early full weight bearing (FWB) after uncemented total hip arthroplasty (THA). METHODS: We conducted a search in PubMed, EMBASE, The Cochrane Library, and Web of Science for randomized controlled trials (RCTs) and non-RCTs comparing PWB and early FWB after uncemented THA. Two authors conducted the selection of studies, data extraction, and assessment of risk of bias independently...
February 17, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28138341/the-foot-orthoses-versus-hip-exercises-fohx-trial-for-patellofemoral-pain-a-protocol-for-a-randomized-clinical-trial-to-determine-if-foot-mobility-is-associated-with-better-outcomes-from-foot-orthoses
#10
RANDOMIZED CONTROLLED TRIAL
Mark Matthews, Michael Skovdal Rathleff, Andrew Claus, Tom McPoil, Robert Nee, Kay Crossley, Jessica Kasza, Sanjoy Paul, Rebecca Mellor, Bill Vicenzino
BACKGROUND: Patellofemoral pain (PFP) is a prevalent, often recalcitrant and multifactorial knee pain condition. One method to optimize treatment outcome is to tailor treatments to the patient's presenting characteristics. Foot orthoses and hip exercises are two such treatments for PFP with proven efficacy yet target different ends of the lower limb with different proposed mechanisms of effect. These treatments have not been compared head-to-head, so there is a dearth of evidence for which to use clinically...
2017: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/28126693/differences-in-knee-adduction-moment-between-healthy-subjects-and-patients-with-osteoarthritis-depend-on-the-knee-axis-definition
#11
S Meireles, F De Groote, S Van Rossom, S Verschueren, I Jonkers
OBJECTIVE: This study, firstly, investigates the effect of using an anatomical versus a functional axis of rotation (FAR) on knee adduction moment (KAM) in healthy subjects and patients with knee osteoarthritis (KOA). Secondly, this study reports KAM for models with FAR calculated using weight-bearing and non-weight-bearing motion. DESIGN: Three musculoskeletal models were created using OpenSim with different knee axis of rotation (AR): transepicondylar axis (TEA); FAR calculated based on SARA algorithm using a weight-bearing motion (wFAR) and a non-weight-bearing motion (nwFAR)...
January 19, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28126324/does-weight-bearing-assignment-after-intramedullary-nail-placement-alter-healing-of-tibial-shaft-fractures
#12
D A Greenhill, M Poorman, C Pinkowski, F V Ramsey, C Haydel
INTRODUCTION: There is no consensus regarding postoperative weight-bearing (WB) assignment after treatment of tibial shaft fractures with an intramedullary nail. This study aims to determine if the postoperative WB assignment after tibia intramedullary nail placement alters healing. METHODS: Closed AO type 42A fractures treated with a reamed statically-locked intramedullary nail over a 10-year period were retrospectively reviewed from injury at 2, 3, 6, 9 and 12 month intervals until union or revision...
February 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28117876/interventions-to-prevent-and-treat-corticosteroid-induced-osteoporosis-and-prevent-osteoporotic-fractures-in-duchenne-muscular-dystrophy
#13
REVIEW
Jennifer M Bell, Michael D Shields, Janet Watters, Alistair Hamilton, Timothy Beringer, Mark Elliott, Rosaline Quinlivan, Sandya Tirupathi, Bronagh Blackwood
BACKGROUND: Corticosteroid treatment is considered the 'gold standard' for Duchenne muscular dystrophy (DMD); however, it is also known to induce osteoporosis and thus increase the risk of vertebral fragility fractures. Good practice in the care of those with DMD requires prevention of these adverse effects. Treatments to increase bone mineral density include bisphosphonates and vitamin D and calcium supplements, and in adolescents with pubertal delay, testosterone. Bone health management is an important part of lifelong care for patients with DMD...
January 24, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27922288/medial-gastrocnemius-myotendinous-junction-displacement-and-plantar-flexion-strength-in-patients-treated-with-immediate-rehabilitation-after-achilles-tendon-repair
#14
RANDOMIZED CONTROLLED TRIAL
Carlos I De la Fuente, Roberto Peña Y Lillo, Rodrigo Ramirez-Campillo, Pablo Ortega-Auriol, Mauricio Delgado, Joel Alvarez-Ruf, Gabriel Carreño
CONTEXT: Pathologic plantar flexion frequently occurs after operative repair of the Achilles tendon (AT) because of immobilization and non-weight bearing in the first weeks of traditional rehabilitation. Novel rehabilitation strategies that apply mobilization and weight bearing have been proposed, but their effects on medial gastrocnemius myotendinous junction displacement (MJD) and isometric plantar-flexion strength (PFS) are unknown. OBJECTIVE: To compare the effects of 12 weeks of immediate versus traditional rehabilitation on MJD and PFS in patients with percutaneous AT repair and to compare AT rupture scores (ATRSs) during follow-up...
December 2016: Journal of Athletic Training
https://www.readbyqxmd.com/read/27723012/poorly-designed-research-does-not-help-clarify-the-role-of-hyperbaric-oxygen-in-the-treatment-of-chronic-diabetic-foot-ulcers
#15
EDITORIAL
Mesut Mutluoglu, Gunalp Uzun, Michael Bennett, Peter Germonpré, David Smart, Daniel Mathieu
Diabetic foot ulcers (DFUs) are one of the most common indications for hyperbaric oxygen treatment (HBOT). The role of HBOT in DFUs is often debated. Recent evidence based guidelines, while recommending its use, urge further studies to identify the patient subgroups most likely to benefit from HBOT. A recent study in Diabetes Care aimed to assess the efficacy of HBOT in reducing the need for major amputation and improving wound healing in patients with chronic DFUs. In this study, patients with Wagner grade 2-4 diabetic foot lesions were randomly assigned to have HBOT (30 sessions/90 min/244 kPa) or sham treatment (30 sessions/90 min/air/125 kPa)...
September 2016: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://www.readbyqxmd.com/read/27587310/safety-and-efficacy-of-transplantation-with-allogeneic-skin-tumors-to-treat-chemically-induced-skin-tumors-in-mice
#16
Zhiwei Zhang, Hua Sun, Jianhua Zhang, Chunlei Ge, Suwei Dong, Zhen Li, Ruilei Li, Xiaodan Chen, Mei Li, Yun Chen, Yingying Zou, Zhongyi Qian, Lei Yang, Jinyan Yang, Zhitao Zhu, Zhimin Liu, Xin Song
BACKGROUND Transplantation with allogeneic cells has become a promising modality for cancer therapy, which can induce graft-versus-tumor (GVT) effect. This study was aimed at assessing the safety, efficacy, and tissue type GVT (tGVT) response of transplantation with allogeneic skin tumors to treat chemically-induced skin tumors in mice. MATERIAL AND METHODS FVB/N and ICR mice were exposed topically to chemicals to induce skin tumors. Healthy ICR mice were transplanted with allogeneic skin tumors from FVB/N mice to test the safety...
September 2, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27519815/fundus-autofluorescence-lifetimes-are-increased-in-non-proliferative-diabetic-retinopathy
#17
Johanna Schmidt, Sven Peters, Lydia Sauer, Dietrich Schweitzer, Matthias Klemm, Regine Augsten, Nicolle Müller, Martin Hammer
PURPOSE: To discriminate non-proliferative diabetic retinopathy (NPDR) patients from healthy controls by fluorescence lifetime imaging ophthalmoscopy (FLIO). METHODS: A prototype FLIO (Heidelberg-Engineering, Heidelberg, Germany) was used to examine the retina of 33 patients and 28 controls. As increased fluorescence of the diabetic lens is known, the lenses of 34 patients and 24 controls were investigated as well. Time-resolved decay was detected in two spectral channels (ch1: 498-560 nm, ch2: 560-720 nm) and approximated by a series of three exponential functions yielding in lifetimes (τ1 , τ2 , τ3 ), amplitudes (α1 , α2 , α3 ) and their amplitude-weighted means (τm )...
February 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27416778/falls-risk-post-stroke-examining-contributions-from-paretic-versus-non-paretic-limbs-to-unexpected-forward-gait-slips
#18
Tejal Kajrolkar, Tanvi Bhatt
Community-dwelling stroke survivors show a high incidence of falls with unexpected external perturbations during dynamic activities like walking. Previous evidence has demonstrated the importance of compensatory stepping to restore dynamic stability in response to perturbations in hemiparetic stroke survivors. However, these studies were limited to either stance perturbations or perturbation induced under the unaffected limb. This study aimed to compare the differences, if any, between the non-paretic and paretic sides in dynamic stability and protective stepping strategies when exposed to unexpected external perturbation during walking...
September 6, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27371292/early-weight-bearing-versus-delayed-weight-bearing-in-medial-opening-wedge-high-tibial-osteotomy-a-randomized-controlled-trial
#19
Joris Radboud Lansdaal, Tanguy Mouton, Daniel Charles Wascher, Guillaume Demey, Sebastien Lustig, Philippe Neyret, Elvire Servien
PURPOSE: The need for a period of non-weight bearing after medial opening wedge high tibial osteotomy remains controversial. It is hypothesized that immediate weight bearing after medial opening wedge high tibial osteotomy would have no difference in functional scores at one year compared to delayed weight bearing. METHODS: Fifty patients, median age 54 years (range 40-65), with medial compartment osteoarthritis, underwent a medial opening wedge high tibial osteotomy utilizing a locking plate without bone grafting...
July 1, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/27158263/safety-of-total-hip-arthroplasty-for-femoral-neck-fractures-using-the-direct-anterior-approach-a-retrospective-observational-study-in-86-elderly-patients
#20
Grégoire Thürig, Jürgen Wilfried Schmitt, Ksenija Slankamenac, Clément M L Werner
BACKGROUND: The femoral neck fracture is one of the most common fractures in the elderly. A variety of methods and approaches are used to treat it. Total hip arthroplasty is a preferred approach in independent, mobile, elderly patients, given its more favorable long-term outcome. Our hypothesis is that the direct anterior approach in geriatric trauma patients has a lower dislocation-rate with the advantage of early recovery due to a muscle sparing approach and therefore early possible full weight-bearing...
2016: Patient Safety in Surgery
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