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https://www.readbyqxmd.com/read/28212661/partial-versus-early-full-weight-bearing-after-uncemented-total-hip-arthroplasty-a-meta-analysis
#1
Peng Tian, Zhi-Jun Li, Gui-Jun Xu, Xiao-Lei Sun, Xin-Long Ma
BACKGROUND: This meta-analysis aimed to investigate the efficacy and safety of partial weight bearing (PWB) versus early full weight bearing (FWB) after uncemented total hip arthroplasty (THA). METHODS: We conducted a search in PubMed, EMBASE, The Cochrane Library, and Web of Science for randomized controlled trials (RCTs) and non-RCTs comparing PWB and early FWB after uncemented THA. Two authors conducted the selection of studies, data extraction, and assessment of risk of bias independently...
February 17, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28138341/the-foot-orthoses-versus-hip-exercises-fohx-trial-for-patellofemoral-pain-a-protocol-for-a-randomized-clinical-trial-to-determine-if-foot-mobility-is-associated-with-better-outcomes-from-foot-orthoses
#2
Mark Matthews, Michael Skovdal Rathleff, Andrew Claus, Tom McPoil, Robert Nee, Kay Crossley, Jessica Kasza, Sanjoy Paul, Rebecca Mellor, Bill Vicenzino
BACKGROUND: Patellofemoral pain (PFP) is a prevalent, often recalcitrant and multifactorial knee pain condition. One method to optimize treatment outcome is to tailor treatments to the patient's presenting characteristics. Foot orthoses and hip exercises are two such treatments for PFP with proven efficacy yet target different ends of the lower limb with different proposed mechanisms of effect. These treatments have not been compared head-to-head, so there is a dearth of evidence for which to use clinically...
2017: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/28126693/differences-in-knee-adduction-moment-between-healthy-subjects-and-patients-with-osteoarthritis-depend-on-the-knee-axis-definition
#3
S Meireles, F De Groote, S Van Rossom, S Verschueren, I Jonkers
OBJECTIVE: This study, firstly, investigates the effect of using an anatomical versus a functional axis of rotation (FAR) on knee adduction moment (KAM) in healthy subjects and patients with knee osteoarthritis (KOA). Secondly, this study reports KAM for models with FAR calculated using weight-bearing and non-weight-bearing motion. DESIGN: Three musculoskeletal models were created using OpenSim with different knee axis of rotation (AR): transepicondylar axis (TEA); FAR calculated based on SARA algorithm using a weight-bearing motion (wFAR) and a non-weight-bearing motion (nwFAR)...
January 19, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28126324/does-weight-bearing-assignment-after-intramedullary-nail-placement-alter-healing-of-tibial-shaft-fractures
#4
D A Greenhill, M Poorman, C Pinkowski, F V Ramsey, C Haydel
INTRODUCTION: There is no consensus regarding postoperative weight-bearing (WB) assignment after treatment of tibial shaft fractures with an intramedullary nail. This study aims to determine if the postoperative WB assignment after tibia intramedullary nail placement alters healing. METHODS: Closed AO type 42A fractures treated with a reamed statically-locked intramedullary nail over a 10-year period were retrospectively reviewed from injury at 2, 3, 6, 9 and 12 month intervals until union or revision...
January 23, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28117876/interventions-to-prevent-and-treat-corticosteroid-induced-osteoporosis-and-prevent-osteoporotic-fractures-in-duchenne-muscular-dystrophy
#5
REVIEW
Jennifer M Bell, Michael D Shields, Janet Watters, Alistair Hamilton, Timothy Beringer, Mark Elliott, Rosaline Quinlivan, Sandya Tirupathi, Bronagh Blackwood
BACKGROUND: Corticosteroid treatment is considered the 'gold standard' for Duchenne muscular dystrophy (DMD); however, it is also known to induce osteoporosis and thus increase the risk of vertebral fragility fractures. Good practice in the care of those with DMD requires prevention of these adverse effects. Treatments to increase bone mineral density include bisphosphonates and vitamin D and calcium supplements, and in adolescents with pubertal delay, testosterone. Bone health management is an important part of lifelong care for patients with DMD...
January 24, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27922288/medial-gastrocnemius-myotendinous-junction-displacement-and-plantar-flexion-strength-in-patients-treated-with-immediate-rehabilitation-after-achilles-tendon-repair
#6
RANDOMIZED CONTROLLED TRIAL
Carlos I De la Fuente, Roberto Peña Y Lillo, Rodrigo Ramirez-Campillo, Pablo Ortega-Auriol, Mauricio Delgado, Joel Alvarez-Ruf, Gabriel Carreño
CONTEXT: Pathologic plantar flexion frequently occurs after operative repair of the Achilles tendon (AT) because of immobilization and non-weight bearing in the first weeks of traditional rehabilitation. Novel rehabilitation strategies that apply mobilization and weight bearing have been proposed, but their effects on medial gastrocnemius myotendinous junction displacement (MJD) and isometric plantar-flexion strength (PFS) are unknown. OBJECTIVE: To compare the effects of 12 weeks of immediate versus traditional rehabilitation on MJD and PFS in patients with percutaneous AT repair and to compare AT rupture scores (ATRSs) during follow-up...
December 2016: Journal of Athletic Training
https://www.readbyqxmd.com/read/27723012/poorly-designed-research-does-not-help-clarify-the-role-of-hyperbaric-oxygen-in-the-treatment-of-chronic-diabetic-foot-ulcers
#7
EDITORIAL
Mesut Mutluoglu, Gunalp Uzun, Michael Bennett, Peter Germonpré, David Smart, Daniel Mathieu
Diabetic foot ulcers (DFUs) are one of the most common indications for hyperbaric oxygen treatment (HBOT). The role of HBOT in DFUs is often debated. Recent evidence based guidelines, while recommending its use, urge further studies to identify the patient subgroups most likely to benefit from HBOT. A recent study in Diabetes Care aimed to assess the efficacy of HBOT in reducing the need for major amputation and improving wound healing in patients with chronic DFUs. In this study, patients with Wagner grade 2-4 diabetic foot lesions were randomly assigned to have HBOT (30 sessions/90 min/244 kPa) or sham treatment (30 sessions/90 min/air/125 kPa)...
September 2016: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://www.readbyqxmd.com/read/27587310/safety-and-efficacy-of-transplantation-with-allogeneic-skin-tumors-to-treat-chemically-induced-skin-tumors-in-mice
#8
Zhiwei Zhang, Hua Sun, Jianhua Zhang, Chunlei Ge, Suwei Dong, Zhen Li, Ruilei Li, Xiaodan Chen, Mei Li, Yun Chen, Yingying Zou, Zhongyi Qian, Lei Yang, Jinyan Yang, Zhitao Zhu, Zhimin Liu, Xin Song
BACKGROUND Transplantation with allogeneic cells has become a promising modality for cancer therapy, which can induce graft-versus-tumor (GVT) effect. This study was aimed at assessing the safety, efficacy, and tissue type GVT (tGVT) response of transplantation with allogeneic skin tumors to treat chemically-induced skin tumors in mice. MATERIAL AND METHODS FVB/N and ICR mice were exposed topically to chemicals to induce skin tumors. Healthy ICR mice were transplanted with allogeneic skin tumors from FVB/N mice to test the safety...
September 2, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27519815/fundus-autofluorescence-lifetimes-are-increased-in-non-proliferative-diabetic-retinopathy
#9
Johanna Schmidt, Sven Peters, Lydia Sauer, Dietrich Schweitzer, Matthias Klemm, Regine Augsten, Nicolle Müller, Martin Hammer
PURPOSE: To discriminate non-proliferative diabetic retinopathy (NPDR) patients from healthy controls by fluorescence lifetime imaging ophthalmoscopy (FLIO). METHODS: A prototype FLIO (Heidelberg-Engineering, Heidelberg, Germany) was used to examine the retina of 33 patients and 28 controls. As increased fluorescence of the diabetic lens is known, the lenses of 34 patients and 24 controls were investigated as well. Time-resolved decay was detected in two spectral channels (ch1: 498-560 nm, ch2: 560-720 nm) and approximated by a series of three exponential functions yielding in lifetimes (τ1 , τ2 , τ3 ), amplitudes (α1 , α2 , α3 ) and their amplitude-weighted means (τm )...
February 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27416778/falls-risk-post-stroke-examining-contributions-from-paretic-versus-non-paretic-limbs-to-unexpected-forward-gait-slips
#10
Tejal Kajrolkar, Tanvi Bhatt
Community-dwelling stroke survivors show a high incidence of falls with unexpected external perturbations during dynamic activities like walking. Previous evidence has demonstrated the importance of compensatory stepping to restore dynamic stability in response to perturbations in hemiparetic stroke survivors. However, these studies were limited to either stance perturbations or perturbation induced under the unaffected limb. This study aimed to compare the differences, if any, between the non-paretic and paretic sides in dynamic stability and protective stepping strategies when exposed to unexpected external perturbation during walking...
September 6, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27371292/early-weight-bearing-versus-delayed-weight-bearing-in-medial-opening-wedge-high-tibial-osteotomy-a-randomized-controlled-trial
#11
Joris Radboud Lansdaal, Tanguy Mouton, Daniel Charles Wascher, Guillaume Demey, Sebastien Lustig, Philippe Neyret, Elvire Servien
PURPOSE: The need for a period of non-weight bearing after medial opening wedge high tibial osteotomy remains controversial. It is hypothesized that immediate weight bearing after medial opening wedge high tibial osteotomy would have no difference in functional scores at one year compared to delayed weight bearing. METHODS: Fifty patients, median age 54 years (range 40-65), with medial compartment osteoarthritis, underwent a medial opening wedge high tibial osteotomy utilizing a locking plate without bone grafting...
July 1, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/27158263/safety-of-total-hip-arthroplasty-for-femoral-neck-fractures-using-the-direct-anterior-approach-a-retrospective-observational-study-in-86-elderly-patients
#12
Grégoire Thürig, Jürgen Wilfried Schmitt, Ksenija Slankamenac, Clément M L Werner
BACKGROUND: The femoral neck fracture is one of the most common fractures in the elderly. A variety of methods and approaches are used to treat it. Total hip arthroplasty is a preferred approach in independent, mobile, elderly patients, given its more favorable long-term outcome. Our hypothesis is that the direct anterior approach in geriatric trauma patients has a lower dislocation-rate with the advantage of early recovery due to a muscle sparing approach and therefore early possible full weight-bearing...
2016: Patient Safety in Surgery
https://www.readbyqxmd.com/read/26794921/computer-assisted-alignment-of-opening-wedge-high-tibial-osteotomy-provides-limited-improvement-of-radiographic-outcomes-compared-to-flouroscopic-alignment
#13
COMPARATIVE STUDY
Jeremy C Stanley, Kerian G Robinson, Brian M Devitt, Anneka K Richmond, Kate E Webster, Timothy S Whitehead, Julian A Feller
INTRODUCTION: There are numerous methods available to assist surgeons in the accurate correction of varus alignment during medial opening wedge high tibial osteotomy (MOWHTO). Preoperative planning performed with radiographs or more recently intraoperative computer navigation software has been used. The aim of the study was to compare the accuracy of computer navigated versus non-navigated techniques to correct varus alignment of the knee. METHOD: The preoperative and postoperative radiographs of 117 knees that underwent MOWHTO were investigated to assess radiographic limb alignment 12-months postoperatively...
March 2016: Knee
https://www.readbyqxmd.com/read/26626489/the-effect-of-regadenoson-induced-transient-disruption-of-the-blood-brain-barrier-on-temozolomide-delivery-to-normal-rat-brain
#14
Sadhana Jackson, Nicole M Anders, Antonella Mangraviti, Teresia M Wanjiku, Eric W Sankey, Ann Liu, Henry Brem, Betty Tyler, Michelle A Rudek, Stuart A Grossman
The blood-brain barrier (BBB) significantly reduces the delivery of many systemically administered agents to the central nervous system. Although temozolomide is the only chemotherapy to improve survival in patients with glioblastoma, its concentration in brain is only 20 % of that in blood. Regadenoson, an FDA approved adenosine receptor agonist used for cardiac stress testing, transiently disrupts rodent BBB allowing high molecular weight dextran (70 kD) to enter the brain. This study was conducted to determine if regadenoson could facilitate entry of temozolomide into normal rodent brain...
February 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/26578305/locking-plate-versus-non-locking-plate-in-open-wedge-high-tibial-osteotomy-a-meta-analysis
#15
Jae Hwi Han, Hyun Jung Kim, Jae Gwang Song, Jae Hyuk Yang, Ryuichi Nakamura, Daivesh Shah, Young Jee Park, Kyung Wook Nha
PURPOSE: The purpose of this study was to conduct a meta-analysis to determine whether the locking plate or non-locking plate results in better opening-wedge high tibial osteotomy (OWHTO) outcomes. METHODS: The MEDLINE, EMBASE, COCHRANE, and KOREAMED register databases were searched for studies. The eligibility criteria for inclusion in the review were studies that compared the locking plate with the non-locking plate for OWHTO, and those that provided clear descriptions of surgical techniques and outcomes...
November 14, 2015: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/26497382/tumor-induced-lymph-node-alterations-detected-by-mri-lymphography-using-gadolinium-nanoparticles
#16
S C Partridge, B F Kurland, C-L Liu, R J Y Ho, A Ruddell
Contrast-enhanced MRI lymphography shows potential to identify alterations in lymph drainage through lymph nodes (LNs) in cancer and other diseases. MRI studies have typically used low molecular weight gadolinium contrast agents, however larger gadolinium-loaded nanoparticles possess characteristics that could improve the specificity and sensitivity of lymphography. The performance of three gadolinium contrast agents with different sizes and properties was compared by 3T MRI after subcutaneous injection. Mice bearing B16-F10 melanoma footpad tumors were imaged to assess tumor-induced alterations in lymph drainage through tumor-draining popliteal and inguinal LNs versus contralateral uninvolved drainage...
October 26, 2015: Scientific Reports
https://www.readbyqxmd.com/read/26303968/three-dimensional-in%C3%A2-vitro-measurements-of-tooth-wear-using-fluoridated-dentifrices
#17
A Al-Mashhadani, I Plygkos, L Bozec, J M Rodriguez
BACKGROUND: The aim of this study was to compare differences in wear of human enamel and dentine in vitro using a 3D measurement method comparing silica versus non-silica containing fluoridated dentifrices (Colgate Total(™) [CT] or Fluor Protector Gel(™) [FPG]). METHODS: Mounted native enamel (n = 36) and polished dentine (n = 36) samples were subjected to 10 wear cycles. Each cycle consisted of: (1) 1 hour remineralization in artificial saliva (AS); (2) 10 minute erosion (0...
September 2016: Australian Dental Journal
https://www.readbyqxmd.com/read/26225170/positional-pelvic-organ-prolapse-pop-evaluation-using-open-weight-bearing-magnetic-resonance-imaging-mri
#18
Boris Friedman, Lynn Stothers, Darren Lazare, Andrew Macnab
INTRODUCTION: Magnetic resonance imaging (MRI) of patients with pelvic organ prolapse (POP) is completed in the supine position. Open magnetic resonance imaging (MRO) uses vertical magnets, allowing imaging in a variety of upright postures. This pilot study used MRO to evaluate the change of prolapse in different positions compared to non-prolapsed images. METHODS: In total, 11 women (6 POP, 5 controls) aged 24 to 65 years had 12 MRO images (midline sagittal pelvic line) consecutively when supine, sitting and standing with a full and empty bladder...
May 2015: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/26100856/gluteal-muscle-function-and-size-in-swimmers
#19
Adam I Semciw, Rodney A Green, Tania Pizzari
OBJECTIVES: To compare the gluteus medius and minimus segments size and activity in swimmers versus non-swimmers. DESIGN: Case matched-control cross-sectional study. METHODS: The three segments of gluteus medius (anterior, middle and posterior) and two segments of gluteus minimus (anterior and posterior) were evaluated using electromyography and magnetic resonance imaging in 15 swimmers (7 elite and 8 non-elite) and 15 gender- and aged-matched controls...
June 2016: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/26090979/four-weeks-in-a-single-leg-weight-bearing-hip-spica-cast-is-sufficient-treatment-for-isolated-femoral-shaft-fractures-in-children-aged-1-to-3-years
#20
Sami Jaafar, Ali Sobh, Julie E Legakis, Ronald Thomas, Kelsey Buhler, Eric T Jones
BACKGROUND: Hip spica casting regimens for the treatment of femoral shaft fractures in a pediatric population aged 1 to 3 years vary. Patient charts were reviewed to determine if there are any clinical differences between 3 and 4 weeks in an ambulatory single-leg hip spica (SLHS) cast versus 6 to 8 weeks in a standard double-leg, non-weight-bearing hip spica cast. METHODS: The medical records of 109 patients with femoral shaft fractures treated with a hip spica casting from January 1, 2008 to December 31, 2011 were examined...
October 2016: Journal of Pediatric Orthopedics
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