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weight bearing versus non weight bearing

Mesut Mutluoglu, Gunalp Uzun, Michael Bennett, Peter Germonpré, David Smart, Daniel Mathieu
Diabetic foot ulcers (DFUs) are one of the most common indications for hyperbaric oxygen treatment (HBOT). The role of HBOT in DFUs is often debated. Recent evidence based guidelines, while recommending its use, urge further studies to identify the patient subgroups most likely to benefit from HBOT. A recent study in Diabetes Care aimed to assess the efficacy of HBOT in reducing the need for major amputation and improving wound healing in patients with chronic DFUs. In this study, patients with Wagner grade 2-4 diabetic foot lesions were randomly assigned to have HBOT (30 sessions/90 min/244 kPa) or sham treatment (30 sessions/90 min/air/125 kPa)...
September 2016: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
Zhiwei Zhang, Hua Sun, Jianhua Zhang, Chunlei Ge, Suwei Dong, Zhen Li, Ruilei Li, Xiaodan Chen, Mei Li, Yun Chen, Yingying Zou, Zhongyi Qian, Lei Yang, Jinyan Yang, Zhitao Zhu, Zhimin Liu, Xin Song
BACKGROUND Transplantation with allogeneic cells has become a promising modality for cancer therapy, which can induce graft-versus-tumor (GVT) effect. This study was aimed at assessing the safety, efficacy, and tissue type GVT (tGVT) response of transplantation with allogeneic skin tumors to treat chemically-induced skin tumors in mice. MATERIAL AND METHODS FVB/N and ICR mice were exposed topically to chemicals to induce skin tumors. Healthy ICR mice were transplanted with allogeneic skin tumors from FVB/N mice to test the safety...
2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Johanna Schmidt, Sven Peters, Lydia Sauer, Dietrich Schweitzer, Matthias Klemm, Regine Augsten, Nicolle Müller, Martin Hammer
PURPOSE: To discriminate non-proliferative diabetic retinopathy (NPDR) patients from healthy controls by fluorescence lifetime imaging ophthalmoscopy (FLIO). METHODS: A prototype FLIO (Heidelberg-Engineering, Heidelberg, Germany) was used to examine the retina of 33 patients and 28 controls. As increased fluorescence of the diabetic lens is known, the lenses of 34 patients and 24 controls were investigated as well. Time-resolved decay was detected in two spectral channels (ch1: 498-560 nm, ch2: 560-720 nm) and approximated by a series of three exponential functions yielding in lifetimes (τ1 , τ2 , τ3 ), amplitudes (α1 , α2 , α3 ) and their amplitude-weighted means (τm )...
August 13, 2016: Acta Ophthalmologica
Tejal Kajrolkar, Tanvi Bhatt
Community-dwelling stroke survivors show a high incidence of falls with unexpected external perturbations during dynamic activities like walking. Previous evidence has demonstrated the importance of compensatory stepping to restore dynamic stability in response to perturbations in hemiparetic stroke survivors. However, these studies were limited to either stance perturbations or perturbation induced under the unaffected limb. This study aimed to compare the differences, if any, between the non-paretic and paretic sides in dynamic stability and protective stepping strategies when exposed to unexpected external perturbation during walking...
June 6, 2016: Journal of Biomechanics
Joris Radboud Lansdaal, Tanguy Mouton, Daniel Charles Wascher, Guillaume Demey, Sebastien Lustig, Philippe Neyret, Elvire Servien
PURPOSE: The need for a period of non-weight bearing after medial opening wedge high tibial osteotomy remains controversial. It is hypothesized that immediate weight bearing after medial opening wedge high tibial osteotomy would have no difference in functional scores at one year compared to delayed weight bearing. METHODS: Fifty patients, median age 54 years (range 40-65), with medial compartment osteoarthritis, underwent a medial opening wedge high tibial osteotomy utilizing a locking plate without bone grafting...
July 1, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Grégoire Thürig, Jürgen Wilfried Schmitt, Ksenija Slankamenac, Clément M L Werner
BACKGROUND: The femoral neck fracture is one of the most common fractures in the elderly. A variety of methods and approaches are used to treat it. Total hip arthroplasty is a preferred approach in independent, mobile, elderly patients, given its more favorable long-term outcome. Our hypothesis is that the direct anterior approach in geriatric trauma patients has a lower dislocation-rate with the advantage of early recovery due to a muscle sparing approach and therefore early possible full weight-bearing...
2016: Patient Safety in Surgery
Jeremy C Stanley, Kerian G Robinson, Brian M Devitt, Anneka K Richmond, Kate E Webster, Timothy S Whitehead, Julian A Feller
INTRODUCTION: There are numerous methods available to assist surgeons in the accurate correction of varus alignment during medial opening wedge high tibial osteotomy (MOWHTO). Preoperative planning performed with radiographs or more recently intraoperative computer navigation software has been used. The aim of the study was to compare the accuracy of computer navigated versus non-navigated techniques to correct varus alignment of the knee. METHOD: The preoperative and postoperative radiographs of 117 knees that underwent MOWHTO were investigated to assess radiographic limb alignment 12-months postoperatively...
March 2016: Knee
Sadhana Jackson, Nicole M Anders, Antonella Mangraviti, Teresia M Wanjiku, Eric W Sankey, Ann Liu, Henry Brem, Betty Tyler, Michelle A Rudek, Stuart A Grossman
The blood-brain barrier (BBB) significantly reduces the delivery of many systemically administered agents to the central nervous system. Although temozolomide is the only chemotherapy to improve survival in patients with glioblastoma, its concentration in brain is only 20 % of that in blood. Regadenoson, an FDA approved adenosine receptor agonist used for cardiac stress testing, transiently disrupts rodent BBB allowing high molecular weight dextran (70 kD) to enter the brain. This study was conducted to determine if regadenoson could facilitate entry of temozolomide into normal rodent brain...
February 2016: Journal of Neuro-oncology
Jae Hwi Han, Hyun Jung Kim, Jae Gwang Song, Jae Hyuk Yang, Ryuichi Nakamura, Daivesh Shah, Young Jee Park, Kyung Wook Nha
PURPOSE: The purpose of this study was to conduct a meta-analysis to determine whether the locking plate or non-locking plate results in better opening-wedge high tibial osteotomy (OWHTO) outcomes. METHODS: The MEDLINE, EMBASE, COCHRANE, and KOREAMED register databases were searched for studies. The eligibility criteria for inclusion in the review were studies that compared the locking plate with the non-locking plate for OWHTO, and those that provided clear descriptions of surgical techniques and outcomes...
November 14, 2015: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
S C Partridge, B F Kurland, C-L Liu, R J Y Ho, A Ruddell
Contrast-enhanced MRI lymphography shows potential to identify alterations in lymph drainage through lymph nodes (LNs) in cancer and other diseases. MRI studies have typically used low molecular weight gadolinium contrast agents, however larger gadolinium-loaded nanoparticles possess characteristics that could improve the specificity and sensitivity of lymphography. The performance of three gadolinium contrast agents with different sizes and properties was compared by 3T MRI after subcutaneous injection. Mice bearing B16-F10 melanoma footpad tumors were imaged to assess tumor-induced alterations in lymph drainage through tumor-draining popliteal and inguinal LNs versus contralateral uninvolved drainage...
October 26, 2015: Scientific Reports
A Al-Mashhadani, I Plygkos, L Bozec, J M Rodriguez
BACKGROUND: The aim of this study was to compare differences in wear of human enamel and dentine in vitro using a 3D measurement method comparing silica versus non-silica containing fluoridated dentifrices (Colgate Total(™) [CT] or Fluor Protector Gel(™) [FPG]). METHODS: Mounted native enamel (n = 36) and polished dentine (n = 36) samples were subjected to 10 wear cycles. Each cycle consisted of: (1) 1 hour remineralization in artificial saliva (AS); (2) 10 minute erosion (0...
September 2016: Australian Dental Journal
Boris Friedman, Lynn Stothers, Darren Lazare, Andrew Macnab
INTRODUCTION: Magnetic resonance imaging (MRI) of patients with pelvic organ prolapse (POP) is completed in the supine position. Open magnetic resonance imaging (MRO) uses vertical magnets, allowing imaging in a variety of upright postures. This pilot study used MRO to evaluate the change of prolapse in different positions compared to non-prolapsed images. METHODS: In total, 11 women (6 POP, 5 controls) aged 24 to 65 years had 12 MRO images (midline sagittal pelvic line) consecutively when supine, sitting and standing with a full and empty bladder...
May 2015: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
Adam I Semciw, Rodney A Green, Tania Pizzari
OBJECTIVES: To compare the gluteus medius and minimus segments size and activity in swimmers versus non-swimmers. DESIGN: Case matched-control cross-sectional study. METHODS: The three segments of gluteus medius (anterior, middle and posterior) and two segments of gluteus minimus (anterior and posterior) were evaluated using electromyography and magnetic resonance imaging in 15 swimmers (7 elite and 8 non-elite) and 15 gender- and aged-matched controls...
June 2016: Journal of Science and Medicine in Sport
Sami Jaafar, Ali Sobh, Julie E Legakis, Ronald Thomas, Kelsey Buhler, Eric T Jones
BACKGROUND: Hip spica casting regimens for the treatment of femoral shaft fractures in a pediatric population aged 1 to 3 years vary. Patient charts were reviewed to determine if there are any clinical differences between 3 and 4 weeks in an ambulatory single-leg hip spica (SLHS) cast versus 6 to 8 weeks in a standard double-leg, non-weight-bearing hip spica cast. METHODS: The medical records of 109 patients with femoral shaft fractures treated with a hip spica casting from January 1, 2008 to December 31, 2011 were examined...
October 2016: Journal of Pediatric Orthopedics
Xiaoxi Ji, Ramona L Reisdorf, Andrew R Thoreson, Lawrence R Berglund, Steven L Moran, Gregory D Jay, Kai-Nan An, Peter C Amadio, Chunfeng Zhao
BACKGROUND: Functional restoration is the major concern after flexor tendon reconstruction in the hand. The purpose of the present study was to investigate the effects of modifying the surface of extrasynovial tendon autografts with carbodiimide-derivatized synovial fluid with gelatin (cd-SF-G) on functional outcomes of flexor tendon reconstruction using a canine model. METHODS: The second and fifth flexor digitorum profundus tendons from eleven dogs were transected and repaired in zone II...
June 17, 2015: Journal of Bone and Joint Surgery. American Volume
R M Sellei, E Bauer, M Hofman, P Kobbe, P Lichte, R L Garrison, H C Pape, K Horst
BACKGROUND: Acute quadriceps tendon tears are infrequent injuries requiring surgical treatment. Improved stability after surgical repair may allow for earlier weight-bearing and range of motion. Therefore, a new implant was tested and compared with the "gold standard", using transosseous sutures. METHODS: Quadriceps tendon tears were constructed using a cadaveric model of 12 fresh matched-pair specimens (aged 61-97; mean age: 82 years). The biomechanical testing compared non-absorbable suture anchors (Polyvinylidene fluoride) versus transosseous absorbable sutures (Polydioxanon)...
December 2015: Knee
Murat Korkmaz, Mustafa Fatih Erkoc, Sadiye Yolcu, Ozlem Balbaloglu, Zekeriya Öztemur, Fatih Karaaslan
INTRODUCTION: Achilles tendon rupture (ATR) often occurs in 40- to 50-year-old men. Multiple studies discuss the correct treatment strategy based on surgical or nonsurgical intervention, including early mobilization. We aimed to compare the outcomes of bearing weight on the same day with non-weight bearing over a 4-week period of ATR patients. MATERIALS AND METHOD: Forty-seven ATR patients were conservatively treated and entered into our study. Group 1 consisted of 23 patients treated with partial weight bearing beginning the same day of conservative treatment; Group 2 consisted of 24 patients treated with non-weight bearing after a 4-week period...
May 2015: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
Alvin Chen, Joshua Balogun-Lynch, Kavita Aggarwal, Elizabeth Dick, Chinmay M Gupte
The aims of this study were to: [1] Assess the number of patients with suspected knee osteoarthritis that underwent repeat weight-bearing(WB) knee radiographs in the orthopaedic clinic following initial non-WB radiograph requested by their general practitioner (GP). [2] Confirm whether repeating WB knee views changed radiology reports. [3] Determine the number of London trusts with protocols for routinely performing WB views. A Retrospective cohort study of 1968 patients aged >40 years referred to a London teaching hospital for knee radiographs over 12 months...
2014: SpringerPlus
Vrisha Madhuri, Vivek Dutt, Abhay D Gahukamble, Prathap Tharyan
BACKGROUND: Fractures of the femoral shaft in children are relatively uncommon but serious injuries that disrupt the lives of children and their carers and can result in significant long-term disability. Treatment involves either surgical fixation, such as intramedullary nailing or external fixation, or conservative treatment involving prolonged immobilisation, often in hospital. OBJECTIVES: To assess the effects (benefits and harms) of interventions for treating femoral shaft fractures in children and adolescents...
December 2014: Evidence-based Child Health: a Cochrane Review Journal
Mohamed Fadel, Mohamed Ali Ahmed, Ahmed Mounir Al-Dars, Mustafa Ahmed Maabed, Hashem Shawki
PURPOSE: The purpose of this study was to evaluate the outcome of Ilizarov external fixation (IE) versus dynamic compression plate (PO) in the management of extra-articular distal tibial fractures. METHODS: Between 2010 and 2011, extra-articular distal tibial fractures in 40 consecutive patients met the inclusion criteria. They were classified according to AO classification fracture type A (A1, A2, and A3). In a randomized method, two equal groups were managed using either IE or PO...
March 2015: International Orthopaedics
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