keyword
MENU ▼
Read by QxMD icon Read
search

Ketoprofen toxic

keyword
https://www.readbyqxmd.com/read/27883262/phytochemicals-enhance-antioxidant-enzyme-expression-to-protect-against-nsaid-induced-oxidative-damage-of-the-gastrointestinal-mucosa
#1
REVIEW
Yu-Ting Cheng, Chi-Cheng Lu, Gow-Chin Yen
The gastrointestinal mucosa provides the first protective barrier for digested food and xenobiotics, which are easily attacked by toxic substances. Non-steroidal anti-inflammatory drugs (NSAIDs), including aspirin, diclofenac, indomethacin, and ketoprofen, are widely used in clinical medicine, but these drugs may cause oxidative stress, leading to gastrointestinal damage, such as ulcers. Lansoprazol, omeprazole, and other clinical drugs are widely used to treat duodenal and gastric ulcers and haven been shown to have multiple biological functions, such as antioxidant activity and the ability to upregulate antioxidant enzymes in vivo...
November 24, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27668993/life-cycle-assessment-and-costing-of-urine-source-separation-focus-on-nonsteroidal-anti-inflammatory-drug-removal
#2
Kelly A Landry, Treavor H Boyer
Urine source separation has the potential to reduce pharmaceutical loading to the environment, while enhancing nutrient recovery. The focus of this life cycle assessment (LCA) was to evaluate the environmental impacts and economic costs to manage nonsteroidal anti-inflammatory drugs (NSAIDs) (i.e., diclofenac, ibuprofen, ketoprofen and naproxen) and nutrients in human urine. Urine source separation was compared with centralized wastewater treatment (WWT) (biological or upgraded with ozonation). The current treatment method (i...
November 15, 2016: Water Research
https://www.readbyqxmd.com/read/27479466/modeling-of-pharmaceuticals-mixtures-toxicity-with-deviation-ratio-and-best-fit-functions-models
#3
Monika Wieczerzak, Błażej Kudłak, Galina Yotova, Miroslava Nedyalkova, Stefan Tsakovski, Vasil Simeonov, Jacek Namieśnik
The present study deals with assessment of ecotoxicological parameters of 9 drugs (diclofenac (sodium salt), oxytetracycline hydrochloride, fluoxetine hydrochloride, chloramphenicol, ketoprofen, progesterone, estrone, androstenedione and gemfibrozil), present in the environmental compartments at specific concentration levels, and their mutual combinations by couples against Microtox® and XenoScreen YES/YAS® bioassays. As the quantitative assessment of ecotoxicity of drug mixtures is an complex and sophisticated topic in the present study we have used two major approaches to gain specific information on the mutual impact of two separate drugs present in a mixture...
November 15, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27455340/clonidine-overdose-in-a-toddler-due-to-accidental-ingestion-of-a-compounding-cream
#4
Alexis L Cates, Scott M Wheatley, Kenneth D Katz
A 22-month-old girl without any significant medical history accidentally consumed a small amount of a therapeutic compounding cream that contained camphor, gabapentin, clonidine, ketoprofen, and lidocaine. Upon presentation to the emergency department, the child exhibited immediate onset of altered mental status with wide fluctuation in her vital signs, which included intermittent apnea requiring bag-valve mask assistance and endotracheal intubation. Serum laboratory analysis measured a clonidine level of 2...
July 23, 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27393563/alginate-based-hybrid-aerogel-microparticles-for-mucosal-drug-delivery
#5
V S S Gonçalves, P Gurikov, J Poejo, A A Matias, S Heinrich, C M M Duarte, I Smirnova
The application of biopolymer aerogels as drug delivery systems (DDS) has gained increased interest during the last decade since these structures have large surface area and accessible pores allowing for high drug loadings. Being biocompatible, biodegradable and presenting low toxicity, polysaccharide-based aerogels are an attractive carrier to be applied in pharmaceutical industry. Moreover, some polysaccharides (e.g. alginate and chitosan) present mucoadhesive properties, an important feature for mucosal drug delivery...
October 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27285464/prediction-of-fetal-ductus-arteriosus-constriction-by-systemic-and-local-dermatological-formulations-of-nsaids-based-on-pk-pd-analysis
#6
Shingo Tanaka, Satoko Hori, Hiroki Satoh, Yasufumi Sawada
AIM: Use of nonsteroidal antiinflammatory drugs (NSAIDs) during the final trimester of pregnancy can cause fetal toxicity, such as ductus arteriosus (DA) constriction. The aim of this study was to predict quantitatively the fetal DA-constrictive effects of NSAIDs after various routes of administration to the mother by means of harmacokinetic/pharmacodynamic (PK/PD) modeling. METHODS: We evaluated acetaminophen, which is a first-line analgesic/antipyretic for the third trimester of pregnancy, together with the following NSAIDs: indometacin, diclofenac, ibuprofen, flurbiprofen, ketoprofen, loxoprofen, felbinac, naproxen, and celecoxib...
October 2016: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27271522/biodegradation-of-ketoprofen-using-a-microalgal-bacterial-consortium
#7
Maha M Ismail, Tamer M Essam, Yasser M Ragab, Fathia E Mourad
OBJECTIVE: To test the toxicity of ketoprofen (a commonly-used NSAIDs) using two microalgal strains and Artemia sp. following the isolation of bacterial and microalgal strains and testing their ability to biodegrade and tolerate ketoprofen. RESULTS: Chlorella sp. was the most resistant to ketoprofen. A defined bacterial consortium (K2) degraded 5 mM ketoprofen as a sole carbon source both in the dark or continuous illumination. Ketoprofen did not undergo photodegradation...
September 2016: Biotechnology Letters
https://www.readbyqxmd.com/read/27234514/risk-screening-of-pharmaceutical-compounds-in-romanian-aquatic-environment
#8
Stefania Gheorghe, Jana Petre, Irina Lucaciu, Catalina Stoica, Mihai Nita-Lazar
The aquatic environment is under increased pressure by pharmaceutically active compounds (PhACs) due to anthropogenic activities. In spite of being found at very low concentrations (ng/L to μg/L) in the environment, PhACs represent a real danger to aquatic ecosystems due to their bioaccumulation and long-term effects. In this study, the presence in the aquatic environment of six non-steroidal anti-inflammatory drugs (ibuprofen, diclofenac, acetaminophen, naproxen, indomethacin, and ketoprofen), caffeine, and carbamazepine were monitored...
December 0: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/27124106/protective-effects-of-combined-%C3%AE-caryophyllene-and-silymarin-against-ketoprofen-induced-hepatotoxicity-in-rats
#9
Mohamed Elsayed Kelany, Mohamed Abdelmohsen Abdallah
Ketoprofen (Ket), widely utilized in treatment of many inflammatory disorders, is found to induce liver toxicity especially with overdose. This study aimed to evaluate the possible protective effects of concomitant β-caryophyllene (Cary) and silymarin (Sily) against Ket-induced hepatotoxicity in rats. Forty adult male albino rats were divided into 5 groups (each n = 8): the control group received distilled water for 6 weeks; the Ket-treated group received distilled water for 5 weeks and Ket in a dose of 8 mg·kg(-1)·day(-1) p...
July 2016: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/27088191/pomegranate-seed-oil-nanoemulsions-improve-the-photostability-and-in-vivo-antinociceptive-effect-of-a-non-steroidal-anti-inflammatory-drug
#10
Luana Mota Ferreira, Marcel Henrique Marcondes Sari, Verônica Ferrari Cervi, Mailine Gehrcke, Allanna Valentini Barbieri, Vanessa Angonesi Zborowski, Ruy Carlos Ruver Beck, Cristina Wayne Nogueira, Letícia Cruz
The combination of pomegranate seed oil and ketoprofen in nanoemulsions aiming to improve the antinociceptive effect was evaluated according to the writhing test and Complete Freud's Adjuvant induced paw inflammation in mice. The formulations showed adequate characteristics and improved ketoprofen's photostability against UVC radiation exposure. The dialysis bag technique showed that 100% of the drug was released from the nanoemulsions after 3h and the oil amount had no influence on the releasing. Furthermore, time- and dose-response curves were obtained to determine the antinociceptive effect of the formulations...
August 1, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/26515938/use-of-hydrodynamic-cavitation-in-waste-water-treatment
#11
REVIEW
Matevž Dular, Tjaša Griessler-Bulc, Ion Gutierrez-Aguirre, Ester Heath, Tina Kosjek, Aleksandra Krivograd Klemenčič, Martina Oder, Martin Petkovšek, Nejc Rački, Maja Ravnikar, Andrej Šarc, Brane Širok, Mojca Zupanc, Miha Žitnik, Boris Kompare
The use of acoustic cavitation for water and wastewater treatment (cleaning) is a well known procedure. Yet, the use of hydrodynamic cavitation as a sole technique or in combination with other techniques such as ultrasound has only recently been suggested and employed. In the first part of this paper a general overview of techniques that employ hydrodynamic cavitation for cleaning of water and wastewater is presented. In the second part of the paper the focus is on our own most recent work using hydrodynamic cavitation for removal of pharmaceuticals (clofibric acid, ibuprofen, ketoprofen, naproxen, diclofenac, carbamazepine), toxic cyanobacteria (Microcystis aeruginosa), green microalgae (Chlorella vulgaris), bacteria (Legionella pneumophila) and viruses (Rotavirus) from water and wastewater...
March 2016: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/26512724/the-safety-and-pharmacokinetics-of-carprofen-flunixin-and-phenylbutazone-in-the-cape-vulture-gyps-coprotheres-following-oral-exposure
#12
Tamsyn Fourie, Duncan Cromarty, Neil Duncan, Kerri Wolter, Vinny Naidoo
The following study evaluates the overt toxic potential of carprofen (CRP), flunixin (FXN) and phenylbutazone (PBZ) in Old world vultures in relation to historic toxicity data for diclofenac and ketoprofen, with the Cape vulture (Gyps coprotheres) being the indicator species. The toxic potential of a single oral dose of CRP (11.5 mg/kg), FXN (1 mg/kg),PBZ (1.7 mg/kg) or water was evaluated by means of a four-way parallel study (n = 2), as means of ascertaining if these drugs were as toxic as diclofenac in the vulture...
2015: PloS One
https://www.readbyqxmd.com/read/26257197/separation-and-on-line-preconcentration-of-nonsteroidal-anti-inflammatory-drugs-by-microemulsion-electrokinetic-chromatography
#13
Chia-Wen Chang, Yu-Cheng Chen, Chuen-Ying Liu
The MEEKC separation and on-line preconcentration of nonsteroidal anti- inflammatory drugs (NSAIDs) were investigated. In this work, two microemulsion (ME) systems were employed. Complete separation could be achieved at a pH of 5.5 with octane as the oil phase (ME I). The LODs for the determination of flurbiprofen, fenoprofen, naproxen, ketoprofen, suprofen and indoprofen were 0.45, 0.32, 0.10, 0.48, 0.77 and 0.29 mg/mg, respectively. To enhance the sensitivity, anion selective exhaustive injection-sweeping (ASEI-sweeping) and stacking with reverse migrating pseudostationary phase (SRMP) were compared...
August 8, 2015: Electrophoresis
https://www.readbyqxmd.com/read/26191985/monitoring-the-concentrations-of-nonsteroidal-anti-inflammatory-drugs-and-cyclooxygenase-inhibiting-activities-in-the-surface-waters-of-the-tone-canal-and-edo-river-basin
#14
Iwaki Nishi, Tsuyoshi Kawakami, Sukeo Onodera
Environmental pollution by pharmaceuticals has become a major problem in many countries worldwide. However, little is known about the concentrations of pharmaceuticals in water sources in Japan. The objective of this study was to clarify variations in the concentrations of seven nonsteroidal anti-inflammatory drugs (NSAIDs) and in cyclooxygenase(COX)-inhibiting activities in river water and domestic wastewater collected from the Tone Canal and the Edo River Basin in Japan. Total NSAID concentrations were higher in the Tone Canal than in the Edo River, and the highest concentration was observed at the domestic wastewater inflow point located in the Tone Canal (concentration averages of salicylic acid, ibuprofen, felbinac, naproxen, mefenamic acid, diclofenac, and ketoprofen in wastewater samples were 55...
2015: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/26183440/assessment-of-in-vitro-antiovulatory-activities-of-nonsteroidal-anti-inflammatory-drugs-and-comparison-with-in-vivo-reproductive-toxicities-of-medaka-oryzias-latipes
#15
Hirofumi Yokota, Sayaka Eguchi, Saki Hasegawa, Kana Okada, Fumiko Yamamoto, Ayaka Sunagawa, Marie Tanaka, Rika Yamamoto, Eiko Nakano
Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used therapeutic agents; however, their pharmacological actions raise concerns about potential risks to the reproductive health of aquatic vertebrates. In the present study, a medaka ovulation assay was applied as an in vitro model to evaluate NSAID-induced antiovulatory activity. We first tested five NSAIDs, including diclofenac sodium (DCF), ketoprofen (KP), salicylic acid (SA), mefenamic acid (MA), and acetylsalicylic acid (ASA) for their antiovulatory activities toward the follicles isolated from the ovaries of spawning females...
July 16, 2015: Environmental Toxicology
https://www.readbyqxmd.com/read/25869485/enantioselective-analysis-of-non-steroidal-anti-inflammatory-drugs-in-freshwater-fish-based-on-microextraction-with-a-supramolecular-liquid-and-chiral-liquid-chromatography-tandem-mass-spectrometry
#16
Carmen Caballo, Maria Dolores Sicilia, Soledad Rubio
Toxicity of pharmaceuticals to aquatic biota is still largely unknown, and no research on the stereoselective toxicity of chiral drugs to these organisms has been undertaken to date. Because of the lack of analytical methods available for this purpose, this manuscript deals, for the first time, with the enantioselective analysis of the non-steroidal anti-inflammatory drugs (NSAIDs) ibuprofen, naproxen and ketoprofen in freshwater fish. The method was based on the microextraction of NSAIDs from fish muscle with a supramolecular liquid made up of inverted hexagonal aggregates of decanoic acid, their enantiomeric separation by liquid chromatography onto a (R)-1-naphthylglycine and 3,5-dinitrobenzoic acid stationary phase and quantification by tandem mass spectrometry...
June 2015: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/25814335/a-novel-two-dimensional-liquid-chromatographic-system-for-the-online-toxicity-prediction-of-pharmaceuticals-and-related-substances
#17
Jian Li, Li Xu, Zhi-guo Shi, Min Hu
In this study, a novel two-dimensional liquid chromatographic (2D-LC) system was developed for simultaneous separation and toxicity prediction of pharmaceutical and its related substances. A conventional ODS column was used on the 1st-D to separate the sample; while, bio-partitioning micellar chromatography served as the 2nd-D to predict toxicity of the components. The established system was tested for the toxicity of ibuprofen and its impurities with known toxicity. With only one injection, ibuprofen and its impurities were separated on the 1st-D; and LC50 values of individual impurity were obtained based on the quantitative retention-activity relationships, which agreed well with the reported data...
August 15, 2015: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/25746948/comparative-evaluation-of-polymeric-and-waxy-microspheres-for-combined-colon-delivery-of-ascorbic-acid-and-ketoprofen
#18
F Maestrelli, N Zerrouk, M Cirri, P Mura
The goal of this work was to combine the ketoprofen anti-inflammatory effect with the ascorbic acid antioxidant properties for a more efficient treatment of colonic pathologies. With this aim, microspheres (MS) based on both waxy materials (ceresine, Precirol(®) and Compritol(®)) or hydrophilic biopolymers (pectine, alginate and chitosan) loaded with the two drugs were developed, physicochemically characterized and compared in terms of entrapment efficiency, in vitro release profiles, potential toxicity and drug permeation properties across the Caco-2 cell line...
May 15, 2015: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/25461029/ecotoxicity-of-ketoprofen-diclofenac-atenolol-and-their-photolysis-byproducts-in-zebrafish-danio-rerio
#19
M S Diniz, R Salgado, V J Pereira, G Carvalho, A Oehmen, M A M Reis, J P Noronha
The occurrence of pharmaceutical compounds in wastewater treatment plants and surface waters has been detected worldwide, constituting a potential risk for aquatic ecosystems. Adult zebrafish, of both sexes, were exposed to three common pharmaceutical compounds (atenolol, ketoprofen and diclofenac) and their UV photolysis by-products over seven days. The results show that diclofenac was removed to concentrations<LOD after 5 min of UV irradiation. The oxidative stress response of zebrafish to pharmaceuticals and their photolysis by-products was evaluated through oxidative stress enzymes (glutathione-S-transferase, catalase, superoxide dismutase) and lipid peroxidation...
February 1, 2015: Science of the Total Environment
https://www.readbyqxmd.com/read/25405970/comparative-metabolism-as-a-key-driver-of-wildlife-species-sensitivity-to-human-and-veterinary-pharmaceuticals
#20
REVIEW
Thomas H Hutchinson, Judith C Madden, Vinny Naidoo, Colin H Walker
Human and veterinary drug development addresses absorption, distribution, metabolism, elimination and toxicology (ADMET) of the Active Pharmaceutical Ingredient (API) in the target species. Metabolism is an important factor in controlling circulating plasma and target tissue API concentrations and in generating metabolites which are more easily eliminated in bile, faeces and urine. The essential purpose of xenobiotic metabolism is to convert lipid-soluble, non-polar and non-excretable chemicals into water soluble, polar molecules that are readily excreted...
November 19, 2014: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
keyword
keyword
89996
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"