Daphne P C Vergouwen, Adriaan A van Beek, Joeri de Hoog, Joke H de Boer, Leonoor I Los, Marlies Gijs, Roel J Erckens, Rob M Verdijk, Geert W Haasnoot, Dave L Roelen, Aniki Rothova, Johan Rönnelid, Josianne C Ten Berge, Marco W J Schreurs
Scleritis is a severe and painful ophthalmic disorder, in which a pathogenic role for collagen-directed autoimmunity was repeatedly suggested. We evaluated the presence of sclera-specific antibodies in a large cohort of patients with non-infectious scleritis. Therefore, we prospectively collected serum samples from 121 patients with non-infectious scleritis in a multicenter cohort study in the Netherlands. In addition, healthy (n = 39) and uveitis controls (n = 48) were included. Serum samples were tested for anti-native human type II collagen antibodies using a validated enzyme-linked immunosorbent assay (ELISA)...
February 17, 2024: Journal of Autoimmunity