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HLA B27

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https://www.readbyqxmd.com/read/28086918/atypical-monoarthritis-presentation-in-children-with-oligoarticular-juvenile-idiopathic-arthritis-a-case-series
#1
Natasha Lepore, Megan Cashin, Debra Bartley, Daniela Simona Ardelean
BACKGROUND: Oligoarticular juvenile idiopathic arthritis (oligoJIA), the most common chronic inflammatory arthritis of childhood, usually involves the knees and ankles. Severe oligoJIA monoarthritis presenting in a joint other than knees and ankles, is rare. FINDINGS: We report four children who presented with severe isolated arthritis of the hip, wrist or elbow and were diagnosed with oligoJIA. All four were girls with a median age of 11.5 years. Those with hip arthritis also met the classification criteria for juvenile-onset spondylarthopathy...
January 13, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/28070744/changes-in-patterns-of-uveitis-at-a-tertiary-referral-center-in-northern-italy-analysis-of-990-consecutive-cases
#2
Cimino Luca, Aldigeri Raffaella, Marchi Sylvia, Mastrofilippo Valentina, Viscogliosi Fabiana, Coassin Marco, Soldani Annamaria, Savoldi Luisa, De Fanti Alessandro, Belloni Lucia, Zerbini Alessandro, Parmeggiani Maria, Chersich Matthew, Soriano Alessandra, Salvarani Carlo, Fontana Luigi
PURPOSE: The role of uveitis, an uncommon ocular disease, is often neglected in research and treatment of autoimmune conditions. The study described the spectrum of uveitis at a referral center in North Italy, and compared that to a previously published series of patients. METHODS: We reviewed all patients with uveitis diagnosed from 2013 to 2015 at the Immunology Eye Unit, Arcispedale S. M. Nuova-IRCCS, Reggio Emilia, Italy. We examined patient characteristics, disease spectrum, and etiologies...
January 9, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28070627/-tendinopathy-in-rheumatic-diseases
#3
M Henniger, S Rehart
Involvement of tendons and tendon sheaths is frequently found in the most common inflammatory systemic diseases, rheumatoid arthritis and spondyloarthritis. In rheumatoid arthritis tendon manifestations occur as tenosynovitis, with swelling and pain of the tendons mainly on the hands and feet. In spondyloarthritis the involvement of tendons presents as enthesitis with pain and swelling directly at the attachment points of tendons to the bony structures and more commonly in the lower extremities. Pathological alterations of tendons can be normally visualized by sonography and only sometimes with magnetic resonance imaging (MRI) or scintigraphy...
January 9, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28069576/dysbiosis-and-zonulin-upregulation-alter-gut-epithelial-and-vascular-barriers-in-patients-with-ankylosing-spondylitis
#4
Francesco Ciccia, Giuliana Guggino, Aroldo Rizzo, Riccardo Alessandro, Michele Maria Luchetti, Simon Milling, Laura Saieva, Heleen Cypers, Tommaso Stampone, Paola Di Benedetto, Armando Gabrielli, Alessio Fasano, Dirk Elewaut, Giovanni Triolo
BACKGROUND: Dysbiosis has been recently demonstrated in patients with ankylosing spondylitis (AS) but its implications in the modulation of intestinal immune responses have never been studied. The aim of this study was to investigate the role of ileal bacteria in modulating local and systemic immune responses in AS. METHODS: Ileal biopsies were obtained from 50 HLA-B27(+) patients with AS and 20 normal subjects. Silver stain was used to visualise bacteria. Ileal expression of tight and adherens junction proteins was investigated by TaqMan real-time (RT)-PCR and immunohistochemistry...
January 9, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28062405/presence-of-multiple-spondyloarthritis-spa-features-is-important-but-not-sufficient-for-a-diagnosis-of-axial-spondyloarthritis-data-from-the-spondyloarthritis-caught-early-space-cohort
#5
Z Ez-Zaitouni, P A C Bakker, M van Lunteren, I J Berg, R Landewé, M van Oosterhout, M Lorenzin, D van der Heijde, F A van Gaalen
OBJECTIVES: Concerns have been raised about overdiagnosis of axial spondyloarthritis (axSpA). We investigated whether patients with chronic back pain (CBP) of short duration and multiple SpA features are always diagnosed with axSpA by the rheumatologist, and to what extent fulfilment of the Assessment of SpondyloArthritis International Society (ASAS) axSpA criteria is associated with an axSpA diagnosis. METHODS: Baseline data from 500 patients from the SPondyloArthritis Caught Early cohort which includes patients with CBP (≥3 months, ≤2 years, onset <45 years) were analysed...
January 6, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28062378/chronic-bowel-inflammation-and-inflammatory-joint-disease-pathophysiology
#6
Silvia Speca, Laurent Dubuquoy
Bowel inflammation is closely linked to chronic joint inflammation. Research reported in the 1980s demonstrated bowel inflammation with gross and microscopic pathological features identical to those of Crohn's disease in over 60% of patients with spondyloarthritis (SpA). Numerous prospective studies have evidenced joint involvement in patients with chronic inflammatory bowel disease (CIBD) and bowel inflammation in patients with SpA. Nevertheless, the interactions of joint disease and chronic bowel inflammation remain incompletely elucidated...
January 3, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28054948/rs657075-csf2-is-associated-with-the-disease-phenotype-bas-g-of-ankylosing-spondylitis
#7
Wei-Chiao Chen, James Cheng-Chung Wei, Hsing-Fang Lu, Henry Sung-Ching Wong, Peng Yeong Woon, Yu-Wen Hsu, Jin-Ding Huang, Wei-Chiao Chang
Ankylosing spondylitis (AS) is a systemic autoimmune disease mainly affecting the lumbar spine and sacroiliac joints, and exhibits peripheral inflammatory arthropathy. More than 25 loci have been identified as associated with AS. Because both AS and rheumatoid arthritis (RA) are autoimmune diseases that may share some common genetic factors, we therefore examined if the newly identified RA genetic polymorphisms were associated with AS in a Taiwanese population. In this study, we enrolled 475 AS patients and 11,301 healthy subjects from a Taiwanese biobank as controls...
January 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28051109/ehlers-danlos-syndrome-hypermobility-type-is-associated-with-rheumatic-diseases
#8
Kyla R Rodgers, Jiang Gui, Mary Beth P Dinulos, Richard C Chou
We retrospectively analyzed electronic medical records of patients with Ehlers-Danlos Syndrome hypermobility type (HEDS), including demographic information, workup, rheumatological diagnoses in order to determine its association with rheumatological conditions. HEDS Patients were stratified according to level of workup received (no additional work (physical exam only) = NWU, limited workup = LWU, comprehensive workup = CWU)). HEDS patients were predominantly female (21:4, F:M). The percentage of patients with at least one rheumatological condition was significantly correlated with level of workup (NWU, 9...
January 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28043168/plasma-levels-of-pentraxin-3-in-patients-with-spondyloarthritis
#9
Renato Nisihara, Thelma L Skare, João Otávio Zeni, Henrique Rasera, Karita Lidani, Iara Messias-Reason
CONTEXT: Determining the disease's inflammatory activity in Spondyloarthritis (SpA) is difficult although very important as it is this that drives treatment. OBJECTIVE: To investigate if plasma PTX3 (Pentraxine-3) could act as an inflammatory marker in SpA. METHODS: Eighty one SpA patients (11 with psoriatic arthritis or PsoA and 70 with Ankylosing Spondylitis or AS) and 90 gender and age paired controls were studied for plasma PTX3 levels by ELISA...
January 3, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28042135/developing-a-risk-scoring-model-for-ankylosing-spondylitis-based-on-a-combination-of-hla-b27-single-nucleotide-polymorphism-and-copy-number-variant-markers
#10
(no author information available yet)
No abstract text is available yet for this article.
January 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28029742/functional-interaction-of-erap2-and-hla-b27-activates-the-unfolded-protein-response
#11
Zhenbo Zhang, Francesco Ciccia, Fanxing Zeng, Giuliana Guggino, Kirby Yee, Hasan Abdullah, Mark S Silverberg, Riccardo Alessandro, Giovanni Triolo, Nigil Haroon
OBJECTIVES: The basic mechanisms underlying ankylosing spondylitis (AS) pathogenesis remain unresolved. We previously reported an association of the single nucleotide polymorphisms (SNP) rs2549782 in Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) with AS. It is known that patients homozygous for the G allele (GG) of another ERAP2 SNP rs2248374 have no ERAP2 expression (ERAP2-null). We utilized this information to study the impact of ERAP2 deficiency on HLA-B27 expression in AS patients...
December 28, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28013432/association-of-human-leukocyte-a-b-and-dr-antigens-in-colombian-patients-with-diagnosis-of-spondyloarthritis
#12
Ana M Santos, Paola Peña, Mabel Avila, Ignacio Briceño, Carlos Jaramillo, Gilberto Vargas-Alarcon, Juan C Rueda, Eugenia-Lucia Saldarriaga, Jose-Ignacio Angarita, Nancy Martinez-Rodriguez, John Londono
There is substantial evidence that non-B27 major histocompatibility complex (MHC) genes are associated with spondyloarthritis (SpA). Studies in Mexican and Tunisian populations demonstrated the association of SpA and human leukocyte antigen (HLA) B15. The purpose of this study was to evaluate the association of HLA-A, B, and DR antigens in a group of Colombian patients with a diagnosis of SpA. A total of 189 patients and 100 healthy subjects were included in the present study. All subjects underwent a complete characterization of HLA alleles A, B, and DR...
December 24, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/28008807/the-role-of-hla-class-i-heavy-chain-interactions-with-killer-cell-immunoglobulin-like-receptors-in-immune-regulation
#13
Simon Kollnberger
HLA-class I molecules form trimeric complexes (pMHC) of peptides, class I heavy chains, and β2microglobulins (β2m) that regulate immune responses by binding to T cells and other immune receptors. B2m-free class I heavy chains (FHCs) form on cells either as a consequence of the natural turnover of pMHC or, in the case of HLA-F, are expressed without β2m. Distinct characteristics of certain HLA-class I members, such as HLA-B27 and HLA-F, stabilize these forms facilitating interactions with immune receptors...
2016: Critical Reviews in Immunology
https://www.readbyqxmd.com/read/28002888/discovery-of-t-cell-receptor-beta-motifs-specific-to-hla-b27-ankylosing-spondylitis-by-deep-repertoire-sequence-analysis
#14
Malek Faham, Victoria Carlton, Martin Moorhead, Jianbiao Zheng, Mark Klinger, Francois Pepin, Thomas Asbury, Marissa Vignali, Ryan O Emerson, Harlan S Robins, James Ireland, Emily Baechler-Gillespie, Robert D Inman
OBJECTIVE: Ankylosing spondylitis (AS), a chronic inflammatory disorder, has a striking association with HLA-B27. One hypothesis suggests that a common antigen that binds to HLA-B27 is important for AS disease pathogenesis. We utilized T-cell repertoire next-generation sequencing to determine sequences and motifs that are shared among HLA-B27 positive (B27(+) ) AS patients. METHODS: To identify motifs enriched among B27(+) AS patients, we performed T-cell receptor beta (TCRβ) repertoire sequencing from 191 B27(+) AS patients, 43 B27(neg) AS patients and 227 controls, and we obtained >77 million TCRβ clonotype sequences...
December 21, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27981820/aseptic-hla-b27-positive-spondylodiscitis-decreased-18f-fdg-uptake-after-etanercept-treatment
#15
M Benucci, A Damiani, A Arena, M Infantino, M Manfredi, F Li Gobbi
We observed a 69-year old man suffering from HLA B27 ankylosing spondylitis with persistent night back pain. 18F-FDG-PET/CT showed an increased metabolism at the level of the spinal space of L2-L3, L3-L4 with increased uptake compatible with spondylodiscitis. He started therapy with etanercept 50 mg/week. After six months of treatment repeated testing showed no uptake of the discs and vertebral bodies.
December 16, 2016: Reumatismo
https://www.readbyqxmd.com/read/27973620/a-genome-wide-snp-linkage-analysis-suggests-a-susceptibility-locus-on-6p21-for-ankylosing-spondylitis-and-inflammatory-back-pain-trait
#16
Yanli Zhang, Zetao Liao, Qiujing Wei, Yunfeng Pan, Xinwei Wang, Shuangyan Cao, Zishi Guo, Yuqiong Wu, Ju Rong, Ou Jin, Manlong Xu, Zhiming Lin, Jieruo Gu
OBJECTIVES: To screen susceptibility loci for ankylosing spondylitis (AS) using an affected-only linkage analysis based on high-density single nucleotide polymorphisms (SNPs) in a genome-wide manner. PATIENTS AND METHODS: AS patients from ten families with Cantonese origin of China were enrolled in the study. Blood samples were genotyped using genomic DNA derived from peripheral blood leukocytes by Illumina HumanHap 610-Quad SNP Chip. Genotype data were generated using the Illumina BeadStudio 3...
2016: PloS One
https://www.readbyqxmd.com/read/27965977/lack-of-association-between-genetic-polymorphisms-of-jak-stat-signaling-pathway-genes-and-acute-anterior-uveitis-in-han-chinese
#17
Ling Cheng, Hongsong Yu, Yan Jiang, Juan He, Sisi Pu, Xin Li, Li Zhang
Purpose. This study aimed to investigate the association between single nucleotide polymorphisms (SNPs) of JAK-STAT signaling pathway genes and acute anterior uveitis (AAU) with or without ankylosing spondylitis (AS) in the Han Chinese population. Methods. Eleven SNPs of the JAK1, JAK2, STAT1, IRF1, and NOS2 genes were analyzed in 443 AAU patients with AS, 486 AAU patients without AS, and 714 healthy controls. Genotyping was performed by PCR-RFLP assay or TaqMan® probe assay. The Chi-squared (χ(2)) test and multivariate logistic regression analysis were used to compare the distributions of alleles and genotypes between patients and controls...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27937033/epidemiology-of-uveitis-in-a-tertiary-care-referral-institute-in-north-india
#18
Mohit Dogra, Ramandeep Singh, Aniruddha Agarwal, Ashok Sharma, Simar Rajan Singh, Natasha Gautam, Sonam Yangzes, Ramanuj Samanta, Manu Sharma, Kanika Aggarwal, Aman Sharma, Kusum Sharma, Reema Bansal, Amod Gupta, Vishali Gupta
PURPOSE: To report epidemiology of uveitis in a tertiary-care referral institute in North India. METHODS: Hospital records of patients with uveitis between June 2011 and September 2014 were retrospectively analyzed. RESULTS: Of the 1912 patients, 56.64% were males. Anterior uveitis (43.04%) was the most common manifestation followed by posterior uveitis (24.58%), panuveitis (16.21%), and intermediate uveitis (10.66%). Specific etiologies could be ascertained in 60...
December 12, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27918224/ocular-autoimmune-systemic-inflammatory-infectious-study-oasis-report-1-epidemiology-and-classification
#19
Elizabeth J Chen, Muhammad Amir Bin Ismail, Helen Mi, Su Ling Ho, Wee Kiak Lim, Stephen C Teoh, Rupesh Agrawal
PURPOSE: To report the epidemiology and classification of ocular inflammation at a tertiary eye care center in Singapore. METHODS: Retrospective cohort study of the clinical records of consecutive new cases from the Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS) database from 2004-2015. RESULTS: A total of 2200 patients were studied from the OASIS database. The most common anatomic diagnosis was anterior uveitis (55.9%), posterior uveitis (17...
December 5, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27917632/-early-diagnosis-of-spondyloarthritis
#20
Kristýna Grobelná, Heřman Mann
Spondyloarthritides are chronic inflammatory rheumatic diseases which affect the axial skeleton and/or peripheral joints and have a strong association with HLA-B27 antigen. According to the prevailing symptoms spondyloarthritis can be further divided into predominantly axial or peripheral form.This disease can gradually destroy affected joints with increasing delay between the onset of first symptoms and treatment commencement, therefore early diagnosis and treatment are necessary. Thus, we need to create simple reference strategies to enable primary care physicians effectively identify and refer these patients to a rheumatologist...
2016: Casopís Lékar̆ů C̆eských
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