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https://www.readbyqxmd.com/read/29148402/incidence-and-prevalence-of-axial-spondyloarthritis-methodologic-challenges-and-gaps-in-the-literature
#1
Rhonda Bohn, Maureen Cooney, Atul Deodhar, Jeffrey R Curtis, Amanda Golembesky
OBJECTIVES: The incidence and prevalence of axial spondyloarthritis (axSpA), including ankylosing spondylitis (AS) and non-radiographic (nr-)axSpA, have been investigated in multiple populations, though there is a paucity of population-level data. Here, we identify population-based studies in AS and nr-axSpA, and describe the methodologic challenges in conducting these, outlining potential reasons for disparate incidence and prevalence estimates. METHODS: PubMed and Embase were searched for population-based studies providing incidence and prevalence rates, published in English from 1 Jan 2000-30 Jun 2015...
November 14, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29139030/potential-risk-factors-for-reactive-arthritis-and-persistence-of-symptoms-at-2%C3%A2-years-a-case-control-study-with-longitudinal-follow-up
#2
Helga Raquel Garcia Ferrer, Alexander Azan, Isa Iraheta, Joan Von Feldt, Luis R Espinoza, Julia Manasson, Jose U Scher, Abraham Garcia Kutzbach, Alexis Ogdie
The objective of the study is to determine the risk factors for the development of reactive arthritis (ReA) and examine the factors associated with the persistence of symptoms. Patients with a new diagnosis of ReA and controls with a gastrointestinal (GI), urogenital, or sexually transmitted infection in the 3-6 months prior to study entry were prospectively enrolled in Guatemala City. ReA patients fulfilled the Assessment in Spondyloarthritis International Society criteria for peripheral spondyloarthropathy (SpA)...
November 14, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29135969/hla-b27-correlates-with-the-intracellular-elimination-replication-and-trafficking-of-salmonella-enteritidis-collected-from-reactive-arthritis-patients
#3
Yi Zhao, Honghu Tang, Chunyu Tan, Hua Zhao, Yi Liu
BACKGROUND The aim of this study was to explore the correlation between HLA-B27 and the intracellular elimination, replication, and trafficking of Salmonella enteritidis (S. enteritidis) collected from patients with reactive arthritis. MATERIAL AND METHODS Confocal microscopy, flow cytometry, and sandwich enzyme-linked immunosorbent assay (ELISA) were employed in this study to evaluate the localization of proteins of interest, to assess the intracellular trafficking of S. enteritidis, and to measure the production of cytokines of interest...
November 14, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29125891/profiling-response-to-tnf-inhibitor-treatment-in-axial-spondyloarthritis
#4
Mansour Alazmi, Ismail Sari, Bharath Krishnan, Robert D Inman, Nigil Haroon
OBJECTIVES: Lack of response to TNF inhibitory (TNFi) agents is not uncommon, encountered during the treatment of axial spondyloarthritis (AxSpA) patients and can be classified as primary (PLR) or secondary (SLR) lack of response. The primary aim of this study was to evaluate factors associated with TNFi failure types and their characteristics in AxSpA. METHODS: Adult AxSpA patients who were TNFi naive at the time of baseline evaluation and started on their first biologics for active axial disease were identified...
November 10, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29122311/-uveitis-diagnostic-work-up-recommendations-from-an-expert-committee
#5
P Sève, B Bodaghi, S Trad, J Sellam, D Bellocq, P Bielefeld, D Sène, G Kaplanski, D Monnet, A Brézin, M Weber, D Saadoun, P Cacoub, C Chiquet, L Kodjikian
INTRODUCTION: Diagnostic work-up of uveitis involves many uncertainties. Search for an etiology should take into account the epidemiology of uveitis and focus on the most severe diseases or those, which can be treated. This work was undertaken to establish recommendations for the diagnosis work-up of uveitis. METHODS: Recommendations were developed by a multidisciplinary panel of 15 experts, including internists, ophthalmologists and a rheumatologist and are based on a review of the literature with regard to effectiveness of investigations and the results of the ULISSE study, which is the first prospective study assessing the efficiency of a standardized strategy for the etiological diagnosis of uveitis...
November 6, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29121154/diagnostic-value-of-serum-soluble-interleukin-2-receptor-levels-vs-angiotensin-converting-enzyme-in-patients-with-sarcoidosis-associated-uveitis
#6
Fahriye Groen-Hakan, Laura Eurelings, Josianne C Ten Berge, Jan van Laar, Christian R B Ramakers, Willem A Dik, Aniki Rothova
Importance: New and improved diagnostic tests for sarcoidosis-associated uveitis are needed because the currently available laboratory diagnostic biomarkers (eg, lysozyme and angiotensin-converting enzyme [ACE]) are lacking in high sensitivity and specificity. Objective: To compare the value of soluble interleukin 2 receptor (sIL-2R) with ACE as diagnostic biomarkers of sarcoidosis in patients with uveitis. Design, Setting, and Participants: A cross-sectional retrospective study was conducted using data collected from 249 consecutive patients with uveitis at the Erasmus University Medical Center uveitis outpatient clinic, Rotterdam, the Netherlands, from April 3, 2013, through November 25, 2015...
November 9, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29120678/patterns-of-uveitis-at-two-university-based-referral-centres-in-cape-town-south-africa
#7
Wilna Rautenbach, Jonel Steffen, Derrick Smit, Karin Lecuona, Tonya Esterhuizen
PURPOSE: To analyze the pattern of uveitis at two tertiary hospitals in South Africa which has a high prevalence of HIV, TB and syphilis. METHODS: Data of 198 patients were obtained retrospectively between August 2014 and August 2016, including patient demographics, clinical examination, special investigations and final diagnosis. RESULTS: Infectious uveitis was the most common aetiological category (47%), followed by idiopathic (34.8%) and non-infectious (18...
November 9, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29119482/patterns-of-comorbidity-and-disease-characteristics-among-patients-with-ankylosing-spondylitis-a-cross-sectional-study
#8
Lotta Ljung, Björn Sundström, Johan Smeds, Maria Ketonen, Helena Forsblad-d'Elia
The knowledge of the development of comorbidities in patients with ankylosing spondylitis (AS) is limited. The aim of this study was to analyse associations between AS disease characteristics and comorbidity and to evaluate patterns of comorbidities in patients with AS. Patients with AS, fulfilling the modified New York Criteria, were identified (n = 346, mean age 56 ± 15 years, 75% men, 99% HLA B27 positive). Through a review of the patient records, data on disease activity parameters, laboratory results, disease manifestations, and diagnoses of any clinically significant comorbidity was obtained...
November 8, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29097266/direct-quantitative-measurement-of-the-kinetics-of-hla-specific-antibody-interactions-with-isolated-hla-proteins
#9
Sunil Daga, Harry Moyse, David Briggs, David Lowe, Neil Evans, James Jones, Rico Buchli, Curtis McMurtrey, Arend Mulder, William Hildebrand, Frans Claas, Robert Higgins, Daniel A Mitchell, Daniel Zehnder
HLA specific antibodies vary in their pathogenicity and this is likely to be the net effect of constant chain usage, quantity, specificity, and affinity. Here we have measured the affinity of human monoclonal antibodies for a range of HLA proteins. Purified antibodies and ligands allowed dynamic interactions to be measured directly by surface plasmon resonance. Physiochemical differences between pairs of ligands were quantified using electrostatic mismatch and hydrophobic mismatch scores. All antibodies were characterized by fast on-rates and slow off rates but with a wide range of association rates (kon, 3...
October 31, 2017: Human Immunology
https://www.readbyqxmd.com/read/29073348/gut-microbiota-perturbations-in-reactive-arthritis-and-post-infectious-spondyloarthritis
#10
Julia Manasson, Nan Shen, Helga R Garcia Ferrer, Carles Ubeda, Isa Iraheta, Adriana Heguy, Joan M Von Feldt, Luis R Espinoza, Abraham Garcia Kutzbach, Leopoldo N Segal, Alexis Ogdie, Jose C Clemente, Jose U Scher
OBJECTIVE: Reactive arthritis (ReA) is an inflammatory disorder occurring several weeks after gastrointestinal or genitourinary infections. HLA-B27 positivity is considered a risk factor, though not necessarily predictive of disease incidence. Among non-genetic factors, the intestinal microbiome may play a role in disease susceptibility. The objective of this study was to characterize the gut microbiota and host gene interactions in ReA and post-infectious spondyloarthritis. METHODS: Adult peripheral spondyloarthritis and control subjects with preceding infections that did not develop arthritis were prospectively recruited from a highly prevalent geographic region...
October 26, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29067128/i-bet151-inhibits-expression-of-rankl-opg-mmp3-and-mmp9-in-ankylosing-spondylitis-in-vivo-and-in-vitro
#11
Jianping Fan, Jian Zhao, Jie Shao, Xianzhao Wei, Xiaodong Zhu, Ming Li
Ankylosing spondylitis (AS) is characterized by osteoclastogenesis and inflammatory bone resorption. The present study aimed to investigate the effect of bromodomain and extra-terminal domain (BET) protein inhibitor I-BET151 on AS process. A total of 38 AS Chinese patients were recruited and a further 38 sex- and age-matched healthy participants were selected as control. The Bath AS Function Index and Bath AS Disease Activity Index were assessed in AS patients and levels of erythrocyte sedimentation rate and C-reactive protein were measured in AS and healthy groups...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29043434/-spondyloarthritides
#12
M Rudwaleit
Spondyloarthritides (SpA) are inflammatory rheumatic diseases affecting the axial skeleton, peripheral joints and entheses, and also manifest at extraskeletal sites. According to the more recently introduced nomenclature, predominant axial SpA is distinguished from predominant peripheral SpA. Axial SpA is further divided into radiographic and nonradiographic axial SpA. Genetic factors are relevant, with HLA-B27 being most important. The interleukin 23/17 pathway seems to be relevant and points towards new therapeutic targets...
October 17, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/29037906/uveitis-diagnostic-work-up-a-literature-review-and-recommendations-from-an-expert-committee
#13
REVIEW
Pascal Sève, Patrice Cacoub, Bahram Bodaghi, Salim Trad, Jérémie Sellam, David Bellocq, Philip Bielefeld, Damien Sène, Gilles Kaplanski, Dominique Monnet, Antoine Brézin, Michel Weber, David Saadoun, Christophe Chiquet, Laurent Kodjikian
PURPOSE: Diagnosis of uveitis is difficult. Etiologic investigations should take into account the epidemiology of uveitis and should focus on the most severe forms of the disease and those which can be treated. This study was undertaken to establish recommendations for the diagnosis of uveitis. METHODS: Recommendations were developed by a multidisciplinary panel of 14 experts, including internists, ophthalmologists, and rheumatologists, and are based on a review of the literature and the results of the ULISSE study, which was the first prospective study to assess the efficacy of a standardized strategy for the etiologic diagnosis of uveitis...
October 14, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29037308/topographic-mri-evaluation-of-the-sacroiliac-joints-in-patients-with-axial-spondyloarthritis
#14
Laís Uyeda Aivazoglou, Orlando Rondan Zotti, Marcelo de Medeiros Pinheiro, Moacir Ribeiro de Castro Junior, Andrea Puchnick, Artur da Rocha Corrêa Fernandes, Eloy de Ávila Fernandes
OBJECTIVE: To evaluate the imaging features of spondyloarthritis in magnetic resonance imaging (MRI) of the sacroiliac (SI) joint and topography (in thirds) and affected margin, considering that this issue is rarely addressed in the literature. METHODS: A cross-sectional study evaluating MRI (1.5T) of SI in 16 patients with axial spondyloarthritis, for the presence of acute (subchondral bone edema, enthesitis, synovitis and capsulitis) and chronic (erosions, subchondral bone sclerosis, bony bridges, and fatty infiltration) changes, performed by two blinded radiologists...
September 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/29029331/the-clinical-utility-of-human-leucocyte-antigen-b27-in-axial-spondyloarthritis
#15
Chong Seng Edwin Lim, Raj Sengupta, Karl Gaffney
The association between HLA-B27 and AS was first established in the early 1970s. Since then, our understanding of this disease has changed, such that we now recognize AS to be the extreme of the clinical phenotype within a disease spectrum known as axial SpA (axSpA). Recent advances in therapeutic options have driven the need for earlier diagnosis and many screening strategies have been proposed to facilitate this. In parallel, our understanding of axSpA genetics, and especially the contribution of HLA-B27, has expanded...
September 25, 2017: Rheumatology
https://www.readbyqxmd.com/read/29018906/the-performance-of-classification-criteria-for-juvenile-spondyloarthropathies
#16
Amra Adrovic, Metin Sezen, Kenan Barut, Sezgin Sahin, Cengizhan Acikel, Erkan Demirkaya, Ozgur Kasapcopur
Juvenile spondyloarthropathies (JSpA) are a group of rheumatologic diseases with a disease onset before 16; characterized with enthesitis, lower extremity oligoarthritis, involvement of the axial skeleton and HLA B27 positivity. The diversity of classification criteria along with the phenotype heterogeneity makes the classification of JSpA challenging. The aim of our study was to evaluate the performance of the pre-determined and recently proposed classification criteria for JSpA. The study group consisted of 113 patients with JSpA and 150 patients with juvenile idiopathic arthritis (JIA)...
December 2017: Rheumatology International
https://www.readbyqxmd.com/read/28982344/ankylosing-spondylitis-among-familial-mediterranean-fever-patients
#17
Mira Merashli, Mohammad Hassan A. Noureldine, Yehia Tfayli, Ali Jawad, Imad Uthman
Background: Familial Mediterranean Fever(FMF) is one of the most common hereditary auto-inflammatory diseases especially among Arabs, Armenians, Jews, and Turks characterized by recurrent attacks of fever, abdominal pain and arthritis.Whether the prevalence of ankylosing spondylitis (AS) is increasedin FMF patients is a matter of debate.This review will summarize all the literature datarelevant to this topic. Methods: We searched all the articles throughPubMedand Embase databasesfrom 1963 untilnow addressing the relationship betweenASand FMF patients...
October 3, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/28980897/comparison-of-patients-with-familial-mediterranean-fever-accompanied-with-sacroiliitis-and-patients-with-juvenile-spondyloarthropathy
#18
Hafize Emine Sönmez, Ezgi Deniz Batu, Selcan Demir, Yelda Bilginer, Seza Özen
OBJECTIVES: Familial Mediterranean fever (FMF) is the most common autoinflammatory disease manifesting with self-limited recurrent febrile attacks and polyserositis. Acute recurrent monoarthritis is the most common form of musculoskeletal involvement in FMF; however, up to 5% of FMF patients may develop chronic joint diseases including sacroiliitis. It is difficult to distinguish whether sacroiliitis is a musculoskeletal finding of FMF or whether this is the coexistence of two diseases, FMF and SpA...
September 26, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28968885/patients-with-fibromyalgia-rarely-fulfil-classification-criteria-for-axial-spondyloarthritis
#19
Xenofon Baraliakos, Andrea Regel, Uta Kiltz, Hans-Jürgen Menne, Friedrich Dybowski, Manfred Igelmann, Ludwig Kalthoff, Dietmar Krause, Ertan Saracbasi-Zender, Elmar Schmitz-Bortz, Jürgen Braun
Background: The Assessments of Spondyloarthritis international Society (ASAS) classification criteria for axial spondyloarthritis (axSpA) have been criticized because of insufficient differentiation towards FM. The aim of this study was to compare the performance of currently used classification criteria in patients diagnosed with axSpA or FM. Methods: Patients were prospectively included if diagnosed with axSpA or FM by the treating rheumatologist and evaluated by an independent examiner for fulfilment of the classification criteria for axSpA (ASAS criteria) and/or FM (1990 ACR classification and 2010 ACR diagnostic criteria)...
September 6, 2017: Rheumatology
https://www.readbyqxmd.com/read/28965938/association-between-hidradenitis-suppurativa-and-spondyloarthritis
#20
Marion Fauconier, Ziad Reguiai, Coralie Barbe, Alban Colosio, Jean-Paul Eschard, Jean-Hugues Salmon, Guillaume Direz
OBJECTIVES: We aimed to investigate the existence of an association between hidrosadenitis suppurativa and spondyloarthritis. METHODS: We performed a single-centre, cross-sectional study in patients with hidrosadenitis suppurativa followed in a tertiary care center, and in healthy volunteers without dermatological disease, matched for age (±5 years) and gender. For each subject included, clinical examinations, HLA-B27 testing and sacro-iliac MRI were performed in order to diagnose spondyloarthritis according to the Assessment of SpondyloArthritis international Society (ASAS) criteria...
September 28, 2017: Joint, Bone, Spine: Revue du Rhumatisme
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