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https://www.readbyqxmd.com/read/28736223/semaphorin-3a-in-ankylosing-spondylitis
#1
Hsien-Tzung Liao, Yuh-Feng Lin, Chung-Tei Chou, Chang-Youh Tsai
BACKGROUND/PURPOSE: To determine serum semaphorin 3A (Sema 3A) levels in ankylosing spondylitis (AS). METHODS: Serum Sema 3A was measured in 46 AS patients and 30 healthy controls (HCs). For the patients, we recorded demographic data, disease activity, functional index & global assessment, detected human leukocyte antigen-B27 (HLA-B27), and measured erythrocyte sedimentation rate (ESR) & C-reactive protein (CRP). RESULTS: Sema 3A was higher in AS patients than in HCs (3...
July 14, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28724442/impact-of-obesity-on-the-response-to-tumor-necrosis-factor-inhibitors-in-axial-spondyloarthritis
#2
Raphael Micheroli, Monika Hebeisen, Lukas M Wildi, Pascale Exer, Giorgio Tamborrini, Jürg Bernhard, Burkhard Möller, Pascal Zufferey, Michael J Nissen, Almut Scherer, Adrian Ciurea
BACKGROUND: Few studies have investigated the impact of obesity on the response to tumor necrosis factor inhibitors (TNFi) in patients with axial spondyloarthritis (axSpA). The aim of our study was to investigate the impact of different body mass index (BMI) categories on TNFi response in a large cohort of patients with axSpA. METHODS: Patients with axSpA within the Swiss Clinical Quality Management (SCQM) program were included in the current study if they fulfilled the Assessment in Spondyloarthritis International Society (ASAS) criteria for axSpA, started a first TNFi after recruitment, and had available BMI data as well as a baseline and follow-up visit at 1 year (±6 months)...
July 19, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28693033/axial-involvement-according-to-asas-criteria-in-an-observational-psoriatic-arthritis-cohort
#3
Pedro David Carvalho, Florencia Savy, Carmen Moragues, Xavier Juanola, Jesus Rodriguez-Moreno
The definition of axial involvement in psoriatic arthritis (PsA) is still under debate. Currently, the axial spondyloarthritis (SpA) criteria defined by Assessment of Spondyloarthritis International Society (ASAS) may be the most adequate.(1) The aims of present study were to assess axial involvement according to ASAS criteria in an observational PsA cohort and define the clinical characteristics more associated with this kind of involvement. Our study included consecutive patients who had a visit in a tertiary Rheumatology centre...
April 2017: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/28684556/sacroiliac-radiographic-progression-in-recent-onset-axial-spondyloarthritis-the-5-year-data-of-the-desir-cohort
#4
Maxime Dougados, Alexandre Sepriano, Anna Molto, Miranda van Lunteren, Sofia Ramiro, Manouk de Hooge, Rosaline van den Berg, Victoria Navarro Compan, Christophe Demattei, Robert Landewé, Désirée van der Heijde
OBJECTIVE: To estimate sacroiliac joint radiographic (X-SIJ) progression in patients with axial spondyloarthritis (axSpA) and to evaluate the effects of inflammation on MRI (MRI-SIJ) on X-SIJ progression. METHODS: X-SIJ and MRI-SIJ at baseline and after 2 and 5 years in patients with recent onset axSpA from the DESIR cohort were scored by three central readers. Progression was defined as (1) the shift from non-radiographic (nr) to radiographic (r) sacroiliitis (by modified New York (mNY) criteria) or alternative criteria, (2) a change of at least one grade or (3) a change of at least one grade but ignoring a change from grade 0 to 1...
July 6, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28662723/hla-b27-antigen-in-middle-eastern-and-arab-countries-systematic-review-of-the-strength-of-association-with-axial-spondyloarthritis-and-methodological-gaps
#5
Nelly Raymond Ziade
BACKGROUND: Axial spondyloarthritis (AxSpA) is a relatively frequent and debilitating disease, with a prevalence ranging from 0.1 to 2% in the Caucasian population. Current Assessment of Spondyloarthritis International Society (ASAS) classification criteria of AxSpA rely either on sacroiliitis on imaging plus one SpA feature or positive HLAB27 antigen plus two SpA features, in a patient with chronic low back pain and age at onset of less than 45 years. Therefore, HLA-B27 is a central feature in SpA classification and plays a pivotal role in referral strategies and early diagnosis...
June 29, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28658315/choroidal-change-in-acute-anterior-uveitis-associated-with-human-leukocyte-antigen-b27
#6
Seong Joon Ahn, Ji Hong Kim, Byung Ro Lee
PURPOSE: To evaluate choroidal changes in eyes with acute anterior uveitis associated with human leukocyte antigen (HLA)-B27. METHODS: In 44 patients with first-onset, unilateral, acute-onset (<1 week) anterior uveitis for which diagnostic work-ups revealed positivity only for HLA-B27, wide-field three-dimensional volumetric raster scan using swept-source optical coherence tomography was performed for both eyes. Choroidal thickness was measured by automated segmentation and thickness mapping and compared between eyes with uveitis and the fellow eyes at baseline...
2017: PloS One
https://www.readbyqxmd.com/read/28638311/a-variant-in-runx3-is-associated-with-the-risk-of-ankylosing-spondylitis-in-koreans
#7
Sung-Min Cho, Seung-Hyun Jung, Yeun-Jun Chung
Ankylosing spondylitis (AS) is a chronic autoinflammatory disease that affects the spine and sacroiliac joints. Regarding its etiology, although HLA-B27 is known to be the strongest genetic factor of AS, much evidence suggests the potential contribution of non-MHC genes to the susceptibility to AS. Most of these non-MHC genes have been discovered in non-Asian populations; however, just some of them have been validated in Koreans. In this study, we aimed to identify additional AS-associated single-nucleotide polymorphism (SNP) candidates by replicating the candidate SNPs in Korean AS patients and healthy controls...
June 2017: Genomics & Informatics
https://www.readbyqxmd.com/read/28634696/prominent-midfoot-involvement-in-children-with-enthesitis-related-arthritis-category-of-juvenile-idiopathic-arthritis
#8
Sanat Phatak, Namita Mohindra, Abhishek Zanwar, Amita Aggarwal
Foot involvement is common in juvenile idiopathic arthritis (JIA) but is often unrecognized and difficult to treat. This study was done to assess clinical and radiological involvement of the feet and its impact on function in Indian children with enthesitis-related arthritis (ERA). We enrolled consecutive children with ERA with disease duration of less than 5 years. All patients underwent clinical examination of the feet and filled the juvenile arthritis foot index (JAFI) questionnaire. Ultrasound (US) of foot joints and entheses and extremity magnetic resonance imaging (MRI) scan of one foot were done...
August 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28631696/-ankylosing-spondylitis-and-non-radiographic-axial-spondyloarthritis-two-stages-of-disease
#9
D G Rumyantseva, T V Dubinina, A B Demina, O A Rumyantseva, E M Agafonova, A V Smirnov, Sh F Erdes
AIM: To compare the clinical manifestations of ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nrAxSpA). SUBJECTS AND METHODS: A Moscow early spondyloarthritis cohort has now included 132 patients with axial spondyloarthritis, of whom 69 patients who have been followed up at least 12 months are to be involved in a preliminary analysis. The mean age at the time of inclusion in the study was 28.1±5.5 years; the mean disease duration was 24...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28624373/acute-tubulointerstitial-nephritis-in-an-hla-b27-positive-patient-with-axial-spondyloarthritis-being-treated-with-adalimumab
#10
David Castro Corredor, María Dolores Sánchez de la Nieta, Isabel María de Lara Simón
Antagonists of tumor necrosis factor-alpha (ATNF) are used for the treatment of multiple diseases such as psoriatic arthritis, Crohn's disease, ankylosing spondylitis and juvenile idiopathic arthritis, usually, when they are refractory to first-line treatment(1). The use of ATNF has been associated with the induction of autoimmune diseases such as systemic lupus erythematosus-like disease, vasculitis, sarcoidosis-like diseases and, recently, acute granulomatous tubulointerstitial nephritis. We report a case of acute nongranulomatous tubulointerstitial nephritis in an HLA-B27-positive patient with axial spondyloarthritis and Crohn's disease being treated with adalimumab...
June 14, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28622455/intestinal-metabolites-are-profoundly-altered-in-the-context-of-hla-b27-expression-and-functionally-modulate-disease-in-a-rat-model-of-spondyloarthropathy
#11
Mark Asquith, Sean Davin, Patrick Stauffer, Claire Michell, Cathleen Janowitz, Phoebe Lin, Joe Ensign-Lewis, Jason M Kinchen, Dennis R Koop, Jim Rosenbaum
Objective HLA-B27 associated spondyloarthropathies are associated with an altered intestinal microbiota and bowel inflammation. Therefore, we sought to identify B27-dependent changes in both host and microbial metabolites in the HLA-B27/β2m rat and whether microbiota-derived metabolites could impact disease in this major model of spondyloarthropathy. Methods Cecal contents were collected from 6wk (pre-diseased) and 16wk (diseased) Fischer 344 HLA-B27/β2m transgenic rats and WT controls. Metabolomic profiling was performed by high-throughput gas- and liquid-chromatography-based mass spectrometry...
June 16, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28607176/clinical-features-of-hla-b27-positive-acute-anterior-uveitis-with-or-without-ankylosing-spondylitis-in-a-chinese-cohort
#12
Peizeng Yang, Wenjuan Wan, Liping Du, Qingyun Zhou, Jian Qi, Liang Liang, Chaokui Wang, Lili Wu, Aize Kijlstra
AIMS: To characterise the clinical features of human leucocyte antigen (HLA)-B27(+)acute anterior uveitis (AAU) patients with or without ankylosing spondylitis (AS) and investigate the retinal vascular involvement in these patients. METHODS: A total of 1056 HLA-B27(+) AAU patients (1525 eyes) were retrospectively studied from April 2008 to February 2016. Patients were divided into human leucocyte antigen (HLA)-B27(+)AS(+) and HLA-B27(+)AS(-) group. Clinical features including the onset of uveitis, laterality, the age at first attack, clinical examinations, best corrected visual acuity (BCVA), abnormalities in fundus fluorescence angiography (FFA) and complications were determined and compared between these two groups...
June 12, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28606969/faecal-microbiota-study-reveals-specific-dysbiosis-in-spondyloarthritis
#13
Maxime Breban, Julien Tap, Ariane Leboime, Roula Said-Nahal, Philippe Langella, Gilles Chiocchia, Jean-Pierre Furet, Harry Sokol
OBJECTIVE: Altered microbiota composition or dysbiosis is suspected to be implicated in the pathogenesis of chronic inflammatory diseases, such as spondyloarthritis (SpA) and rheumatoid arthritis (RA). METHODS: 16S ribosomal RNA gene sequencing was performed on faecal DNA isolated from stool samples in two consecutive cross-sectional cohorts, each comprising three groups of adult volunteers: SpA, RA and healthy controls (HCs). In the second study, HCs comprised a majority of aged-matched siblings of patients with known HLA-B27 status...
June 12, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28593426/-spondyloarthritides
#14
M Rudwaleit
Spondyloarthritides (SpA) are inflammatory rheumatic diseases affecting the axial skeleton, peripheral joints and entheses, and also manifest at extraskeletal sites. According to the more recently introduced nomenclature, predominant axial SpA is distinguished from predominant peripheral SpA. Axial SpA is further divided into radiographic and nonradiographic axial SpA. Genetic factors are relevant, with HLA-B27 being most important. The interleukin 23/17 pathway seems to be relevant and points towards new therapeutic targets...
June 7, 2017: Der Internist
https://www.readbyqxmd.com/read/28587658/mri-evidence-of-structural-changes-in-the-sacroiliac-joints-of-patients-with-non-radiographic-axial-spondyloarthritis-even-in-the-absence-of-mri-inflammation
#15
Walter P Maksymowych, Stephanie Wichuk, Maxime Dougados, Heather Jones, Annette Szumski, Jack F Bukowski, Lisa Marshall, Robert G Lambert
BACKGROUND: Studies have shown that structural lesions may be present in patients with non-radiographic axial spondyloarthritis (nr-axSpA). However, the relevance of structural lesions in these patients is unclear, particularly without signs of inflammation on magnetic resonance imaging (MRI). We assessed the presence of structural lesions at baseline on MRI in the sacroiliac joints (SIJ) of patients with nr-axSpA with and without SIJ inflammation on MRI. METHODS: Bone marrow edema (BME) was assessed on short tau inversion recovery (STIR) scans from 185 patients with nr-axSpA, by two independent readers at baseline using the Spondyloarthritis Research Consortium of Canada (SPARCC) score...
June 6, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28584850/a-subset-of-extreme-human-immunodeficiency-virus-hiv-controllers-is-characterized-by-a-small-hiv-blood-reservoir-and-a-weak-t-cell-activation-level
#16
Etienne Canouï, Camille Lécuroux, Véronique Avettand-Fenoël, Marine Gousset, Christine Rouzioux, Asier Saez-Cirion, Laurence Meyer, Faroudy Boufassa, Olivier Lambotte, Nicolas Noël
BACKGROUND: Human immunodeficiency virus controllers (HICs) form a heterogeneous group of patients with regard to formal definitions, immunologic characteristics, and changes over time in viral load. PATIENTS AND METHODS: The HICs with undetectable viral load ([uHICs] ie, for whom a viral load had never been detected with routine assays; n = 52) were compared with 178 HICs with blips during the follow up (bHICs). Clinical characteristics, ultrasensitive HIV-ribonucleic acid (RNA) and HIV-deoxyribonucleic acid (DNA) loads, HIV1-Western blot profiles, and immune parameters were analyzed...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28569265/spondyloarthropathies-gut-bone-crosstalk-in-hla-b27-rats
#17
Joanna Collison
No abstract text is available yet for this article.
July 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28569222/is-the-current-asas-expert-definition-of-a-positive-family-history-useful-in-identifying-axial-spondyloarthritis-results-from-the-space-and-desir-cohorts
#18
Zineb Ez-Zaitouni, Andrea Hilkens, Laure Gossec, Inger Jorid Berg, Robert Landewé, Roberta Ramonda, Maxime Dougados, Désirée van der Heijde, Floris van Gaalen
BACKGROUND: The Assessment of SpondyloArthritis international Society (ASAS) definition of a positive family history (PFH) of spondyloarthritis (SpA) includes the following diseases in first- or second-degree relatives: ankylosing spondylitis (AS), acute anterior uveitis (AAU), reactive arthritis (ReA), inflammatory bowel disease (IBD), and psoriasis. However, it is not known if a PFH for each of these diseases contributes to making a diagnosis of axSpA, sacroiliitis on imaging, or fulfilling the ASAS criteria in patients presenting with chronic back pain (CBP)...
May 31, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28551170/switching-tumor-necrosis-factor-inhibitors-in-the-treatment-of-axial-spondyloarthritis
#19
REVIEW
Atul Deodhar, David Yu
OBJECTIVE: To assess the impact of switching tumor necrosis factor (TNF)-alpha inhibitors on patients with axial spondyloarthritis (axSpA). METHODS: PubMed literature searches were conducted using combinations of search terms including ankylosing spondylitis, spondyloarthropathy, spondyloarthritis, switch/switching, drug survival, and TNF/tumor necrosis factor to identify published articles with data on outcomes related to switching biologic therapies in patients with axSpA...
April 25, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28550390/clinical-patterns-and-characteristics-of-ankylosing-spondylitis-in-china
#20
Qiaoxia Qian, Xia Xu, Hongjun He, Hengdong Ji, Hui Zhang, Yue Ding, Sheng-Ming Dai, Yaohong Zou, Qi Zhu, Chengde Yang, Shuang Ye, Lindi Jiang, Jian-Ping Tang, Qiang Tong, Dongyi He, Dongbao Zhao, Yuan Li, Yanyun Ma, Jingru Zhou, Ziyu Yuan, Juan Zhang, Li Jin, Xiaodong Zhou, John D Reveille, Hejian Zou, Jiucun Wang
The study aimed to determine whether unique clinical patterns of AS may exist in China, specifically to explore the different clinical manifestations caused by gender, HLA-B27 status, and age at disease onset. The multicenter cross-sectional survey was conducted and 1251 patients were enrolled across China, representing a broad spectrum of Chinese AS patients. The mean age at onset and diagnosis were 29.2 (11.4) and 33.5 (12.6) years, respectively. The male/female ratio was 2.7:1. Acute anterior uveitis (AAU) was experienced in 10...
May 27, 2017: Clinical Rheumatology
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