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https://www.readbyqxmd.com/read/28539676/results-from-polish-spondyloarthritis-initiative-registry-polspi-methodology-and-data-from-the-first-year-of-observation
#1
Zofia Guła, Tacjana Barczyńska, Marek Brzosko, Jerzy Gąsowski, Sławomir Jeka, Katarzyna Jodłowska-Cicio, Beata Kwaśny-Krochin, Piotr Leszczyński, Łukasz Lubiński, Katarzyna Łosińska, Katarzyna Pawlak-Buś, Hanna Przepiera-Będzak, Włodzimierz Samborski, Małgorzata Schlabs, Maciej Siedlar, Dorota Sikorska, Jerzy Świerkot, Małgorzata Węgierska, Piotr Wiland, Mariusz Korkosz
OBJECTIVES: Report on one-year results from the Polish Spondyloarthritis Initiative registry (PolSPI), containing the cross-sectional analysis of clinical and imaging data as well as database methodology. MATERIAL AND METHODS: The PolSPI registry includes patients with axial (axSpA) and peripheral (perSpA) spondyloarthritis according to ASAS classification criteria, and/or patients with ankylosing spondylitis according to modified New York criteria, psoriatic arthritis according to CASPAR criteria, arthropathy in inflammatory bowel disease, reactive arthritis, juvenile spondyloarthritis or undifferentiated spondyloarthritis...
2017: Reumatologia
https://www.readbyqxmd.com/read/28537523/the-pattern-of-uveitis-in-sri-lanka
#2
Jay Siak, Mirna Kumaradas, Soon-Phaik Chee
PURPOSE: To describe the pattern of uveitis at a tertiary uveitis referral clinic in Sri Lanka. METHODS: Consecutive charts identified from a registry between January 2010 and December 2014 at the Mediclinic Hospital, Colombo were retrospectively reviewed. RESULTS: Among 750 patients, anterior uveitis (AU) was the most common (285, 38%), followed by posterior uveitis (187, 25%), intermediate uveitis (150, 20%), and panuveitis (128, 17%). 485 (65%) were idiopathic...
May 24, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28526894/association-of-hla-b27-with-ankylosing-spondylitis-and-clinical-features-of-the-hla-b27-associated-ankylosing-spondylitis-a-meta-analysis
#3
Hai Lin, Yi-Zhen Gong
Many studies have estimated the correlation between HLA-B27 polymorphisms and ankylosing spondylitis (AS). However, the results were controversial. Therefore, we performed this meta-analysis to determine the association of HLA-B*27 polymorphisms with AS and investigate the impacts of HLA-B27 on the clinical symptoms of AS patients. A comprehensive search was performed in PubMed, Web of Science and Embase databases to retrieve the eligible studies, which addressed the association between HLA-B27 polymorphisms and AS susceptibility...
May 19, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28516675/analysis-of-platelet-reactive-alloantibodies-and-evaluation-of-cross-match-compatible-platelets-for-the-management-of-patients-with-transfusion-refractoriness
#4
J Wang, W Xia, J Deng, X Xu, Y Shao, H Ding, Y Chen, J Liu, D Chen, X Ye, S Santoso
BACKGROUND: Cross-match-compatible platelets can improve corrected count increments (CCIs) in alloimmunised patients with transfusion refractoriness. However, only a few studies mentioned that the specificities of platelet-reactive alloantibodies can predict high reactivity in cross-match assays among these patients. METHODS: A total of 204 medical records of patients who were refractory to random single-donor apheresis platelets between January 2014 and December 2014 were enrolled...
May 18, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28511292/gut-inflammation-in-hla-b27-transgenic-rats-alters-the-monocyte-compartment-and-its-osteoclastogenic-potential
#5
Cecilia Ansalone, Lotta Utriainen, Simon Milling, Carl S Goodyear
Objective To investigate the relationship between intestinal inflammation and the central and peripheral innate immune system, in the pathogenesis of HLA-B27 associated spondyloarthritis. Methods The myeloid compartment of the bone marrow and blood of HLA-B27 transgenic (B27), control HLA-B7 transgenic (B7), and non-transgenic rats were evaluated by flow cytometry. Plasma from rats were assessed by ELISA for CCL2 and IL-1α levels. Rats were treated for 4 weeks with antibiotics and the blood and bone marrow myeloid compartments were evaluated by flow cytometry...
May 16, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28505673/-hla-b27-positive-acute-anterior-uveitis-a-translational-perspective
#6
Arnd Heiligenhaus, Maren Kasper, Rafael Grajewski
Background HLA-B27 positive acute anterior uveitis is the most common type of uveitis, and it is an autoimmune disease that can be triggered by infections. The precise mechanism of the interaction between involved microbes (mostly gram negative bacteria) and the host immune system is not clear. The disease probably results from an imbalance between pro- and anti-inflammatory components. Project description This article gives a compact overview about the current knowledge of the clinic and the etiopathogenesis of acute anterior uveitis as a basis for future research approaches...
May 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28502944/reactive-arthritis-caused-by-yersinia-enterocolitica-enteritis
#7
Kazuya Honda, Nozomi Iwanaga, Yasumori Izumi, Yoshika Tsuji, Chieko Kawahara, Toru Michitsuji, Shuntaro Higashi, Atsushi Kawakami, Kiyoshi Migita
We report a case of reactive arthritis (ReA) triggered by Yersinia enterocolitica enteritis. A 24-year-old Japanese man developed polyarthritis in the lower limbs. Two weeks prior to these symptoms, he noted diarrhea, right lower abdominal pain and a fever. Y. enterocolitica was not isolated from a stool culture; however, he was diagnosed with ReA based on the colonoscopic findings of a high anti-Y. enterocolitica antibody titer and HLA-B27 antigen positivity. Following treatment with methotrexate and steroids, his arthritis improved...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28496443/higher-levels-of-secretory-iga-are-associated-with-low-disease-activity-index-in-patients-with-reactive-arthritis-and-undifferentiated-spondyloarthritis
#8
Fabián Salas-Cuestas, Wilson Bautista-Molano, Juan M Bello-Gualtero, Ivonne Arias, Diana Marcela Castillo, Lorena Chila-Moreno, Rafael Valle-Oñate, Daniel Herrera, Consuelo Romero-Sánchez
INTRODUCTION: Both reactive arthritis (ReA) and undifferentiated spondyloarthritis (uSpA) belong to the group of autoinflammatory diseases called spondyloarthritis (SpA). Hypotheses have been proposed about a relationship between the intestinal mucosa and inflammation of joint tissues. The role of immunoglobulin IgA or secretory immunoglobulin A (SIgA) in the inflammatory and/or clinical activity of patients with SpA remains poorly understood. OBJECTIVE: To evaluate the status of total IgA and SIgA, and the association among the levels of SIgA, IgA, IgA anti-Chlamydia trachomatis, and anti-Shigella spp...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28464909/multicenter-inception-cohort-of-enthesitis-related-arthritis-variation-in-disease-characteristics-and-treatment-approaches
#9
Sabrina Gmuca, Rui Xiao, Timothy G Brandon, Ilaria Pagnini, Tracey B Wright, Timothy Beukelman, Esi M Morgan, Pamela F Weiss
BACKGROUND: Enthesitis-related arthritis (ERA) is a specific subtype of juvenile idiopathic arthritis (JIA) defined according to the International League of Associations for Rheumatology (ILAR) criteria. We aimed to characterize the clinical features and treatment regimens in an inception cohort of children with ERA. METHODS: We performed a retrospective, cross-sectional, multicenter cohort study including subjects diagnosed with ERA between 1989 and 2012. Patients all fulfilled the ILAR criteria for ERA within 3 months of initial presentation to the rheumatology clinic...
May 2, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28456926/prevalence-of-hla-b27-in-the-general-population-and-in-patients-with-axial-spondyloarthritis-in-saudi-arabia
#10
Mohammed A Omair, Fatmah K AlDuraibi, Mohammed K Bedaiwi, Sultana Abdulaziz, Waleed Husain, Maha El Dessougi, Hind Alhumaidan, Hana J Al Khabbaz, Ibrahim Alahmadi, Maha A Omair, Salman Al Saleh, Khalid Alismael, Moheeb Al Awwami
The prevalence of HLA-B27 in the general population and in axial spondyloarthritis (axSpA) patients in Saudi Arabia is unknown. The aim of this study was to evaluate the prevalence of HLA-B27 in these two populations and describe the delay in diagnosis of axSpA patients. The prevalence of HLA-B27 in the general population was evaluated using cord blood and healthy organ transplant donor databases. Data from patients with axSpA were collected retrospectively from five centers. Ankylosing spondylitis (AS) was diagnosed based on a positive X-ray, as evaluated by two independent readers...
April 29, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28446810/pathogenesis-of-ankylosing-spondylitis-recent-advances-and-future-directions
#11
REVIEW
Vidya Ranganathan, Eric Gracey, Matthew A Brown, Robert D Inman, Nigil Haroon
Over the past 5 years, advances in high-throughput techniques and studies involving large cohorts of patients have led to considerable advances in the identification of novel genetic associations and immune pathways involved in ankylosing spondylitis (AS). These discoveries include genes encoding cytokine receptors, transcription factors, signalling molecules and transport proteins. Although progress has been made in understanding the functions and potential pathogenic roles of some of these molecules, much work remains to be done to comprehend their complex interactions and therapeutic potential in AS...
June 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28413624/recent-advances-in-understanding-spondyloarthritis
#12
REVIEW
J S H Gaston
This review is concerned with a number of recent publications that contribute to current thinking on the pathogenesis of spondyloarthritis. The areas covered include the lymphocyte population in the enthesis, which is thought to drive enthesitis, and hence clinical manifestations. The debate on how HLA-B27 is implicated in inflammation is also considered, together with recent and contradictory evidence on the effects of the peptide-trimming enzyme ERAP1 on B27 expression and hence susceptibility to spondylitis...
2017: F1000Research
https://www.readbyqxmd.com/read/28412700/takayasu-arteritis-and-spondyloarthritis-coincidence-or-association-a-study-of-14-cases
#13
Elodie Rivière, Laurent Arnaud, Mikael Ebbo, Yannick Allanore, Pascal Claudepierre, Emmanuelle Dernis, Jean-Marc Ziza, Corinne Miceli-Richard, Peggy Philippe, Christophe Richez, Martin Soubrier, Rakiba Belkhir, Raphaèle Seror, Xavier Mariette, Stephan Pavy
OBJECTIVE: Spondyloarthritis (SpA) and Takayasu arteritis (TA) are 2 chronic inflammatory diseases; their coexistence in a single patient is uncommon. The aims of our study were to describe clinical features of patients having SpA associated with TA and to identify some characteristics of the types of patients with SpA associated with TA. We also analyzed treatments used in this context. METHODS: This French multicenter retrospective survey called for observations on behalf of the Club Rhumatismes et Inflammations, with a standardized questionnaire established by the investigators...
April 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28408754/lack-of-association-of-c3-gene-with-uveitis-additional-insights-into-the-genetic-profile-of-uveitis-regarding-complement-pathway-genes
#14
Ming Ming Yang, Jun Wang, Li Dong, De Ju Kong, Yan Teng, Ping Liu, Jiao Jie Fan, Xu Hui Yu
Uveitis is a devastating ocular disease that causes blindness. Our previous studies have achieved great advancements in depicting the genetic profiles of uveitis regarding complement pathway genes. This study aimed to provide additional insights into this interest by testing the "central" factor of the complement system, C3 gene variants, in two uveitis entities. Eight haplotype-tagging SNPs of C3 gene were genotyped in 141 anterior uveitis (AU), 158 non-infectious intermediate and posterior uveitis (NIPU) and 293 controls...
April 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28405734/genetic-association-between-tap1-and-tap2-polymorphisms-and-ankylosing-spondylitis-a-systematic-review-and-meta-analysis
#15
Yufeng Qian, Genlin Wang, Feng Xue, Lianghui Chen, Yan Wang, Liang Tang, Huilin Yang
OBJECTIVES: Ankylosing spondylitis (AS) is a chronic inflammatory joint disease. The transporter associated with antigen processing (TAP) has been identified to play an important role in immune response as well as the HLA-associated diseases. The aim of our meta-analysis was to investigate the contribution of TAP (TAP1 and TAP2) polymorphisms to the risk of AS. METHODS: Meta-analyses were performed between 2 polymorphisms in TAP1 (TAP1-333, -637) and 3 polymorphisms in TAP2 (TAP2-379, -565, and -665) and AS...
April 12, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28405472/course-of-patients-with-juvenile-spondyloarthritis-during-4%C3%A2-years-of-observation-juvenile-part-of-gespic
#16
Anja Weiß, Kirsten Minden, Joachim Listing, Ivan Foeldvari, Joachim Sieper, Martin Rudwaleit
OBJECTIVE: To describe the course and the 4-year outcome of juvenile spondyloarthritis (jSpA). METHODS: Patients with a diagnosis of jSpA and an age at onset ≤16 years were included in the German Spondyloarthritis Inception cohort (GESPIC) and followed up prospectively for 4 years. RESULTS: 118 patients (73% men, 66% HLA-B27 positive, mean age 13.5 years, mean symptom duration 2.2 years) were enrolled in 2 study centres: 52% of patients with jSpA were captured by the enthesitis-related arthritis subgroup of the International League of Associations for Rheumatology classification criteria...
2017: RMD Open
https://www.readbyqxmd.com/read/28400866/association-of-erap1-il23r-and-ptger4-polymorphisms-with-radiographic-severity-of-ankylosing-spondylitis
#17
Gulsen Ozen, Rabia Deniz, Fatih Eren, Can Erzik, Ali Ugur Unal, Sule Yavuz, Sibel Zehra Aydin, Nevsun Inanc, Haner Direskeneli, Pamir Atagunduz
BACKGROUND: Radiographic severity of ankylosing spondylitis (AS) shows such great variance that some patients never develop syndesmophytes throughout the entire disease span, whereas some develop bamboo spine relatively early. OBJECTIVE: To study the association between ERAP1, IL23R and PTGER4 single nucleotide polymorphisms (SNPs) and radiographic severity in AS patients. METHODS: rs27044 and rs30187 (ERAP1), rs11209032 (IL23R) and rs10440635 (PTGER4) SNPs were genotyped in 235 AS patients fulfilling the modified New York criteria...
2017: Open Rheumatology Journal
https://www.readbyqxmd.com/read/28397479/estimation-of-diagnostic-markers-in-rheumatoid-arthritis-and-ankylosing-spondylitis
#18
Nasrin Dashti, Zahra Javadi, Fatemeh Safari, Solmaz Farahvash, Mitra Zarebavani
BACKGROUND: Laboratory examination is a great value to confirm a diagnosis and estimate disease activity of Rheumatoid Arthritis (RA) and Ankylosing Spondylitis (AS). Since little research related to the diagnosis of RA and AS has been done in Iran, the aim of the present study was to evaluate the diagnosis markers in patients with RA and AS. METHODS: This study was conducted among 104 patients with RA and 42 patients with AS in Iran during 2016. Inclusion criteria were according to the American College of Rheumatology (ACR) and European League against Rheumatism (EULAR) criteria...
April 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28386763/ankylosing-spondylitis-hla-b-27-positive-versus-hla-b-27-negative-disease
#19
REVIEW
Nurullah Akkoç, Handan Yarkan, Gökçe Kenar, Muhammad A Khan
PURPOSE OF REVIEW: We review our current knowledge about the clinical features of patients with ankylosing spondylitis (AS) who possess HLA-B*27 versus those who lack this gene. RECENT FINDINGS: ERAP1 association is present only in HLA-B*27+ patients, but other genetic associations are similar between the two groups. A genetic study supports the existence of an HLA-B27-independent common link between gut inflammation and AS. It is unusual to observe familial occurrence of primary AS among families of northern European extraction that show no segregation of HLA-B*27, psoriasis, or IBD...
May 2017: Current Rheumatology Reports
https://www.readbyqxmd.com/read/28376061/new-developments-in-uveitis-associated-with-hla-b27
#20
James T Rosenbaum
PURPOSE OF REVIEW: Uveitis is the most common, clinically apparent, extra-articular manifestation of axial spondyloarthritis. This review summarizes recent publications related to this form of uveitis. RECENT FINDINGS: Studies published since the start of 2015 address the worldwide prevalence of human leukocyte antigen (HLA) B27-associated uveitis, the prevalence of axial spondyloarthritis among patients with B27-associated acute anterior uveitis (AAU), the genetics of AAU and some of the clinical implications of AAU...
April 3, 2017: Current Opinion in Rheumatology
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