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HLA B27

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https://www.readbyqxmd.com/read/27918224/ocular-autoimmune-systemic-inflammatory-infectious-study-oasis-report-1-epidemiology-and-classification
#1
Elizabeth J Chen, Muhammad Amir Bin Ismail, Helen Mi, Su Ling Ho, Wee Kiak Lim, Stephen C Teoh, Rupesh Agrawal
PURPOSE: To report the epidemiology and classification of ocular inflammation at a tertiary eye care center in Singapore. METHODS: Retrospective cohort study of the clinical records of consecutive new cases from the Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS) database from 2004-2015. RESULTS: A total of 2200 patients were studied from the OASIS database. The most common anatomic diagnosis was anterior uveitis (55.9%), posterior uveitis (17...
December 5, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27917632/-early-diagnosis-of-spondyloarthritis
#2
Kristýna Grobelná, Heřman Mann
Spondyloarthritides are chronic inflammatory rheumatic diseases which affect the axial skeleton and/or peripheral joints and have a strong association with HLA-B27 antigen. According to the prevailing symptoms spondyloarthritis can be further divided into predominantly axial or peripheral form.This disease can gradually destroy affected joints with increasing delay between the onset of first symptoms and treatment commencement, therefore early diagnosis and treatment are necessary. Thus, we need to create simple reference strategies to enable primary care physicians effectively identify and refer these patients to a rheumatologist...
2016: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/27909141/developing-a-risk-scoring-model-for-ankylosing-spondylitis-based-on-a-combination-of-hla-b27-single-nucleotide-polymorphism-and-copy-number-variant-markers
#3
Seung-Hyun Jung, Sung-Min Cho, Seon-Hee Yim, So-Hee Kim, Hyeon-Chun Park, Mi-La Cho, Seung-Cheol Shim, Tae-Hwan Kim, Sung-Hwan Park, Yeun-Jun Chung
OBJECTIVE: To develop a genotype-based ankylosing spondylitis (AS) risk prediction model that is more sensitive and specific than HLA-B27 typing. METHODS: To develop the AS genetic risk scoring (AS-GRS) model, 648 individuals (285 cases and 363 controls) were examined for 5 copy number variants (CNV), 7 single-nucleotide polymorphisms (SNP), and an HLA-B27 marker by TaqMan assays. The AS-GRS model was developed using logistic regression and validated with a larger independent set (576 cases and 680 controls)...
December 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27909080/ankylosing-spondylitis-versus-nonradiographic-axial-spondyloarthritis-comparison-of-tumor-necrosis-factor-inhibitor-effectiveness-and-effect-of-hla-b27-status-an-observational-cohort-study-from-the-nationwide-danbio-registry
#4
Bente Glintborg, Inge J Sørensen, Mikkel Østergaard, Lene Dreyer, Abdiweli A Mohamoud, Niels S Krogh, Oliver Hendricks, Lis S Andersen, Johnny L Raun, Marcin R Kowalski, Laura Danielsen, Randi Pelck, Henrik Nordin, Jens K Pedersen, Dorte G A Kraus, Susan R Christensen, Inger M J Hansen, Jakob Esbesen, Annette Schlemmer, Anne G Loft, Nabil Al Chaer, Lone Salomonsen, Merete L Hetland
OBJECTIVE: To compare baseline disease activity and treatment effectiveness in biologic-naive patients with nonradiographic axial spondyloarthritis (nr-axSpA) and ankylosing spondylitis (AS) who initiate tumor necrosis factor inhibitor (TNFi) treatment and to study the role of potential confounders (e.g., HLA-B27 status). METHODS: Observational cohort study based on prospectively registered data in the nationwide DANBIO registry. We used Kaplan-Meier plots, Cox, and logistic regression analyses to study the effect of diagnosis (nr-axSpA vs AS) and potential confounders (sex/age/start yr/HLA-B27/disease duration/TNFi-type/smoking/baseline disease activity) on TNFi adherence and response [e...
December 1, 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27906814/prevalence-and-visual-outcome-of-glaucoma-with-uveitis-in-a-thai-population
#5
Kessara Pathanapitoon, Sarunya Smitharuck, Paradee Kunavisarut, Aniki Rothova
OBJECTIVE: The aim of this study was to report on the prevalence of uveitic secondary glaucoma (USG) and ocular hypertension in patients with uveitis in Thailand, and to identify factors associated with the development of USG and its visual outcome. DESIGN: This is a retrospective cohort study. METHODS: We included 174 consecutive uveitis patients (237 affected eyes) visiting the Ophthalmology Department of Chiang Mai University Hospital, Thailand, from January 2013 to March 2013...
November 30, 2016: Journal of Glaucoma
https://www.readbyqxmd.com/read/27901620/etiology-and-clinical-features-of-ocular-inflammatory-diseases-in-a-tertiary-referral-centre-in-sydney-australia
#6
Sophia L Zagora, Richard Symes, Aaron Yeung, Will Yates, Denis Wakefield, Peter J McCluskey
PURPOSE: To report the pattern of uveitis in patients attending a tertiary uveitis service in Sydney, Australia. METHODS: The charts of patients seen between January 2009 and December 2015 were retrospectively reviewed. Data pertaining to patient demographics, eye examination on presentation, work-up and final diagnoses were collected. RESULTS: The total number of patients with uveitis seen over this period was 1165. There were 650 males (56%) and 515 females (44%)...
November 30, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27889235/prevalence-and-topographic-distribution-of-spinal-inflammation-on-mr-imaging-in-patients-recently-diagnosed-with-axial-spondyloarthritis
#7
A Larbi, B Fourneret, C Lukas, M-P Baron, N Molinari, P Taourel, C Cyteval
OBJECTIVE: The primary goal of this study was to determine the prevalence and topographic distribution of spinal lesions in lower thoracic and lumbar spine on magnetic resonance imaging (MRI) in patients with recently diagnosed with spondyloarthritis. The secondary goal was to identify variables associated with vertebral patterns consistent with spondyloarthritis on MRI. PATIENTS AND METHODS: A total of 112 HLA-B27 positive patients with recently diagnosed spondyloarthritis were retrospectively included...
November 23, 2016: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/27879484/herpes-simplex-type-2-encephalitis-and-methotrexate-medication-a-fortuitous-or-causative-association-in-a-patient-with-spondyloarthritis
#8
Julien Lupo, Ophélie Dos Santos, Raphaele Germi, Monique Baccard-Longère, Jean-Paul Stahl, Olivier Epaulard, Patrice Morand
It is unclear whether immunosuppression is a risk factor for herpes encephalitis. Herein, we describe a rare case of herpes simplex virus (HSV) type 2 encephalitis in a patient treated with low-dose methotrexate for HLA-B27-associated spondyloarthritis. The patient was successfully treated with acyclovir but presented sequelae of encephalitis. Here we discuss the possible role of low-dose MTX therapy as a risk factor of neurological herpes reactivation and severe disease. The host-related and viral risk factors are also addressed...
November 23, 2016: Antiviral Therapy
https://www.readbyqxmd.com/read/27869581/physical-activity-in-ankylosing-spondylitis-evaluation-and-analysis-of-an-ehealth-tool
#9
Jess Shelagh Tyrrell, Clare Helen Redshaw
BACKGROUND: Ankylosing spondylitis (AS) is a chronic inflammatory condition characterised by spinal arthritis and exercise is often recommended to reduce the symptoms and improve mobility. However, very little evidence exists for the value of exercise in AS. OBJECTIVES: Firstly, this pilot study aimed to evaluate an eHealth tool, the AS Observer, specifically designed to monitor symptoms, quality of life and physical activity in AS, in terms of patient experience and suitability in generating data for epidemiological studies...
July 4, 2016: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/27861762/gut-microbiome-in-children-with-enthesitis-related-arthritis-in-a-developing-country-and-the-effect-of-probiotic-administration
#10
Amita Aggarwal, Aditya N Sarangi, Priyanka Gaur, Anuj Shukla, Rakesh Aggarwal
In Asia, enthesitis-related arthritis (ERA) is the most-frequent category of juvenile idiopathic arthritis. ERA has a strong association with HLA-B27 and subclinical gut inflammation. In a HLA-B27 transgenic rat model, presence of Bacteroides bacteria in the gut appears to cause spondyloarthropathy (SpA). Thus, we studied gut microbiota in children with ERA. Stool specimens from 33 patients with ERA and 14 age-matched healthy controls were studied; none had any gastrointestinal symptom, or had received a drug known to affect gut motility or microbiota in the preceding 6 weeks...
November 9, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27855706/human-class-i-major-histocompatibility-complex-alleles-determine-central-nervous-system-injury-versus-repair
#11
Bharath Wootla, Aleksandar Denic, Jens O Watzlawik, Arthur E Warrington, Laurie J Zoecklein, Louisa M Papke-Norton, Chella David, Moses Rodriguez
BACKGROUND: We investigated the role of human HLA class I molecules in persistent central nervous system (CNS) injury versus repair following virus infection of the CNS. METHODS: Human class I A11(+) and B27(+) transgenic human beta-2 microglobulin positive (Hβ2m(+)) mice of the H-2 (b) background were generated on a combined class I-deficient (mouse beta-2 microglobulin deficient, β2m(0)) and class II-deficient (mouse Aβ(0)) phenotype. Intracranial infection with Theiler's murine encephalomyelitis virus (TMEV) in susceptible SJL mice results in acute encephalitis with prominent injury in the hippocampus, striatum, and cortex...
November 17, 2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27846758/ankylosing-spondylitis-m-csf-derived-macrophages-are-undergoing-unfolded-protein-response-upr-and-express-higher-levels-of-interleukin-23
#12
Alireza Rezaiemanesh, Mahdi Mahmoudi, Ali Akbar Amirzargar, Mahdi Vojdanian, Ahmad Reza Jamshidi, Mohammad Hossein Nicknam
OBJECTIVE: Interleukin (IL)-23/IL-17 pathway involves in the pathogenesis of ankylosing spondylitis (AS). The exact mechanism implicated in overexpression of IL-23 and activation of the IL-23/IL-17 axis is not clear. The aim of the study was to clarify whether macrophages of AS patients undergo unfolded protein response (UPR) and secret increased IL-23. METHODS: Peripheral blood monocyte isolated from 10 HLA-B27(+) patients and 5 HLA-B27(+) normal subjects were differentiated to macrophages by macrophage-colony stimulating factor (M-CSF) for 7 days...
November 16, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27833598/alteration-of-fecal-microbiota-profiles-in-juvenile-idiopathic-arthritis-associations-with-hla-b27-allele-and-disease-status
#13
Monica Di Paola, Duccio Cavalieri, Davide Albanese, Maddalena Sordo, Massimo Pindo, Claudio Donati, Ilaria Pagnini, Teresa Giani, Gabriele Simonini, Alessia Paladini, Paolo Lionetti, Carlotta De Filippo, Rolando Cimaz
Alteration of gut microbiota is involved in several chronic inflammatory and autoimmune diseases, including rheumatoid arthritis, and gut microbial "pro-arthritogenic" profiles have been hypothesized. Intestinal inflammation may be involved in spondyloarthropathies and in a subset of patients affected by Juvenile Idiopathic Arthritis (JIA), the most common chronic rheumatic disease of childhood. We compared the fecal microbiota composition of JIA patients with healthy subjects (HS), evaluating differences in microbial profiles between sub-categories of JIA, such as enthesitis-related arthritis (JIA-ERA), in which inflammation of entheses occurs, and polyarticular JIA, non-enthesitis related arthritis (JIA-nERA)...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27826329/recurrent-macrophage-activation-syndrome-since-toddler-age-in-an-adolescent-boy-with-hla-b27-positive-juvenile-ankylosing-spondylitis
#14
Joon Hyeong Park, Yu Mi Seo, Seung Beom Han, Ki Hwan Kim, Jung Woo Rhim, Nack Gyun Chung, Myung Shin Kim, Jin Han Kang, Dae Chul Jeong
Recurrent macrophage activation syndrome (MAS) is very rare. We present the case of an adolescent boy with human leukocyte antigen (HLA) B27-positive ankylosing spondylitis (AS), who experienced episodes of recurrent MAS since he was a toddler. A 16-year-old boy was admitted because of remittent fever with pancytopenia and splenomegaly after surgical intervention for an intractable perianal abscess. He had been diagnosed with hemophagocytic lymphohistiocytosis (HLH) 4 different times, which was well controlled with intravenous immunoglobulin and steroids since the age of 3...
October 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/27813310/identifying-axial-spondyloarthritis-in-electronic-medical-records-of-united-states-veterans
#15
Jessica A Walsh, Yijun Shao, Jianwei Leng, Tao He, Chia-Chen Teng, Doug Redd, Qing Treitler Zeng, Zachary Burningham, Daniel O Clegg, Brian C Sauer
OBJECTIVE: Large database research in axial spondyloarthritis (AxSpA) is limited by a lack of methods for identifying most types of AxSpA. Our objective was to develop methods for identifying AxSpA concepts in the free text of documents from electronic medical records. METHODS: Veterans with documents in the national Veteran Health Administration Corporate Data Warehouse between January 1, 2005 and June 30, 2015 were included. Methods were developed for exploring, selecting, and extracting meaningful terms that were likely to represent AxSpA concepts...
November 3, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27801336/-the-specificity-and-limitations-of-sacroiliac-joint-magnetic-resonance-imaging-in-the-diagnosis-of-axial-spondyloarthritis-in-patients-with-chronic-low-back-pain
#16
Y Y Wang, Z Zhao, G Luo, Y Li, J L Zhang, F Huang
Objective: To evaluate the specificity and limitations of sacroiliac joint magnetic resonance imaging (MRI) in the diagnosis of axial spondyloarthritis (SpA)in patients with chronic low back pain. Methods: We retrospectively analyzed clinical data of 390 patients with chronic low back pain in Department of Rheumatology, the PLA General Hospital from January 2013 to December 2015, including clinical manifestations, laboratory examinations and MRI data of sacroiliac joints. Results: There were 238 men and 152 women recruited...
November 1, 2016: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/27800496/serum-hmgb1-serves-as-a-novel-laboratory-indicator-reflecting-disease-activity-and-treatment-response-in-ankylosing-spondylitis-patients
#17
Chenqiong Wang, Ye Miao, Xuefen Wu, Yishu Huang, Mengchen Sun, Yingzi Zhu, Fang Zheng, Wei Sun, Lingli Dong
Objective. High mobility group box 1 (HMGB1) is a late inflammatory factor participating in the pathogenesis of various autoimmune and inflammatory diseases. In the current study, we analyzed the association between serum levels of HMGB1 and clinical features of AS patients before and during treatment. Methods. Serum HMGB1 was detected in 147 AS patients and 61 healthy controls using ELISA. We evaluated the association between HMGB1 and extra-articular manifestations as well as disease severity indices. Among these AS patients, 41 patients received close follow-up at 1, 3, and 6 months after treatment...
2016: Journal of Immunology Research
https://www.readbyqxmd.com/read/27782870/factors-associated-with-the-decision-of-the-rheumatologist-to-order-sacroiliac-joints-magnetic-resonance-imaging-si-mri-or-hla-b27-testing-in-the-diagnostic-work-up-of-patients-with-spondyloarthritis-in-clinical-practice
#18
Wilson Bautista-Molano, Robert B M Landewé, Cesar Serna, Rafael Valle-Oñate, Désirée van der Heijde
OBJECTIVES: To evaluate the patients' characteristics associated with the clinical decision to request SI-MRI and/or HLA-B27 in patients with SpA in daily practice. METHODS: Patients referred to a rheumatology outpatient-clinic in a national referral-centre were selected. Patients with a clinical diagnosis of SpA according to the rheumatologist were included. SI-MRI and HLA-B27 was available for patients in whom the rheumatologists had ordered these tests. Characteristics associated with ordering SI-MRI or HLA-B27 were identified with univariable analyses...
October 26, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27749140/biologic-therapy-for-hla-b27-associated-ocular-disorders
#19
Julie Gueudry, Jennifer E Thorne, Rakesh Bansie, Juergen Braun, P Martin van Hagen, Bahram Bodaghi
The treatment of articular and extra-articular manifestations associated with HLA-B27 has undergone dramatic changes over the past two decades, mainly as a consequence of the introduction of biologic agents and in particular anti-tumor necrosis factor α (anti-TNFα) agents. Uveitis is known to be the most frequent extra-articular feature in HLA-B27-associated spondyloarthritides. Topical corticosteroids and cycloplegic agents remain the cornerstones of treatment. However, biologic therapy may be effective in the management of refractory or recurrent forms of uveitis...
October 17, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27744397/limited-reliability-of-radiographic-assessment-of-sacroiliac-joints-in-patients-with-suspected-early-spondyloarthritis
#20
Alice Ashouri Christiansen, Oliver Hendricks, Dorota Kuettel, Kim Hørslev-Petersen, Anne Grethe Jurik, Steen Nielsen, Kaspar Rufibach, Anne Gitte Loft, Susanne Juhl Pedersen, Louise Thuesen Hermansen, Mikkel Østergaard, Bodil Arnbak, Claus Manniche, Ulrich Weber
OBJECTIVE: To determine the reproducibility of evaluation of sacroiliac joint (SIJ) radiographs among readers with varying levels of experience, and to identify potential drivers of disagreement in classification among 5 predefined radiographic lesion types. METHODS: The study sample consisted of 104 consecutive patients aged 18-40 with low back pain ≥ 3 months of duration who met the Assessment of SpondyloArthritis international Society (ASAS) definition for a positive SIJ magnetic resonance imaging, or were HLA-B27-positive and had ≥ 1 spondyloarthritis (SpA)-related clinical/laboratory feature according to the ASAS classification criteria for axial SpA...
October 15, 2016: Journal of Rheumatology
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