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https://www.readbyqxmd.com/read/29773510/implications-of-the-abcd-study-for-developmental-neuroscience
#1
Sarah W Feldstein Ewing, James M Bjork, Monica Luciana
The Adolescent Brain Cognitive Development Study (ABCD) will capture a breadth of multi-faceted biobehavioral, environmental, familial, and genetic longitudinal developmental open-access data from over 11,000 9-10 year olds throughout the United States of America (USA) for an envisioned ten-year span. This will subsequently represent the largest study ever attempted with this level of brain phenotypic detail. This study holds the opportunity for exciting advances in the understanding of typical adolescent neurodevelopment, discovery of neurodevelopmental underpinnings of mental illness, as well as the neurodevelopmental influences of (and on) social factors, substance use, and critically - their interaction...
May 14, 2018: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/29771745/national-institute-on-drug-abuse-international-program-improving-opioid-use-disorder-treatment-through-international-research-training
#2
Steven W Gust, Judy McCormally
PURPOSE OF REVIEW: For more than 25 years, the National Institute on Drug Abuse (NIDA) has supported research-training programs, establishing a global research network and expanding the knowledge base on substance use disorders. International research to inform approaches to opioid addiction is particularly important and relevant to the United States, where opioid misuse, addiction, and overdose constitute an emerging public health crisis. This article summarizes the NIDA International Program and illustrates its impact by reviewing recent articles about treatment approaches for opioid use disorders (OUD)...
May 15, 2018: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/29758355/alcohol-and-opioid-use-in-chronic-pain-a-cross-sectional-examination-of-differences-in-functioning-based-on-misuse-status
#3
Kevin E Vowles, Katie Witkiewitz, Melissa Pielech, Karlyn A Edwards, Mindy L McEntee, Robert W Bailey, Lena Bolling, Mark D Sullivan
Opioid misuse is regularly associated with disrupted functioning in those with chronic pain. Less work has examined whether alcohol misuse may also interfere with functioning. This study examined frequency of opioid and alcohol misuse in 131 individuals (61.1% female) prescribed opioids for the treatment of chronic pain. Participants completed an anonymous survey online, consisting of measures of pain, functioning, and opioid and alcohol misuse. Cut-scores were used to categorize individuals according to substance misuse status; individuals were categorized as follows: 35...
May 11, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29757920/alaska-nurse-practitioners-barriers-to-use-of-prescription-drug-monitoring-programs
#4
Heath Christianson, Elizabeth Driscoll, Aicha Hull
BACKGROUND AND PURPOSE: Prescription drug monitoring programs (PDMPs) have begun to demonstrate themselves as useful tools in enhancing safe and responsible prescription of controlled substances. The purpose of this project was to describe current practice, beliefs, and barriers of Alaska nurse practitioners (NPs) regarding the Alaska PDMP. METHODS: A questionnaire was sent to 635 Alaskan NPs with a 33% return rate. The data depicted prescribing habits, barriers to use, barriers to registering, and opinions on how to make the PDMP more clinically useful...
January 2018: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/29757460/evaluating-behavioral-economic-models-of-heavy-drinking-among-college-students
#5
Samuel F Acuff, Kathryn E Soltis, Ashley A Dennhardt, Kristoffer S Berlin, James G Murphy
Heavy drinking among college students is a significant public health concern that can lead to profound social and health consequences, including alcohol use disorder. Behavioral economics posits that low future orientation and high valuation of alcohol (alcohol demand) combined with deficits in alternative reinforcement increase the likelihood of alcohol misuse (Bickel et al., 2011). Despite this, no study has examined the incremental utility of all three variables simultaneously in a comprehensive model METHOD: The current study uses structural equation modeling to test the associations between behavioral economic variables - alcohol demand (latent), future orientation (measured with a delay discounting task and the Consideration of Future Consequences (CFC) scale), and proportionate substance-related reinforcement - and alcohol consumption and problems among 393 heavy drinking college students...
May 14, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29757104/rehabilitation-of-drug-abusers-the-roles-of-perceptions-relationships-and-family-supports
#6
Samuel Ojima Adejoh, Olusegun M Temilola, Funmilayo F Adejuwon
The increase in the use, abuse and misuse of psychoactive substances is not just of concern to national government of different countries but poses a big problem to the international community as well as of a global public health challenge. The study explored the perceived influence of perceptions, relationships and family support on rehabilitation of drug abusers undergoing rehabilitation in a rehabilitation centre. The non-experimental study design was used. The study population was that of drug abuse patients undergoing rehabilitation in the Neuropsychiatric Hospital in Lagos...
May 14, 2018: Social Work in Public Health
https://www.readbyqxmd.com/read/29745703/negative-urgency-moderates-reactivity-to-laboratory-stress-inductions
#7
Max M Owens, Michael T Amlung, Monika Stojek, James MacKillop
Impulsive personality traits refer to a group of self-reported dispositions about self-regulatory capacity, several of which have been linked to diverse forms of psychopathology. One of these is negative urgency (NUR), the propensity to act out when experiencing negative emotions, which has been linked to substance use disorders and eating disorders. However, few laboratory studies have investigated the extent to which self-reported NUR relates to an individual's in vivo emotional and behavioral responses. Harmonizing two archival data sets on alcohol and high-energy-dense (HED) food motivation, the current study investigated NUR as a moderator of reactivity to stressful situations elicited by two commonly used stress manipulations, the Trier Social Stress Test and a stress imagery induction...
May 2018: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/29739281/the-association-between-adverse-child-health-psychological-educational-and-social-outcomes-and-nondependent-parental-substance-a-rapid-evidence-assessment
#8
Ruth McGovern, Eilish Gilvarry, Michelle Addison, Hayley Alderson, Emma Geijer-Simpson, Raghu Lingam, Debbie Smart, Eileen Kaner
BACKGROUND: Between 5% and 30% of children in high-income countries live with a substance misusing parent, the majority of which is below dependent levels. However, little is understood about the impact of nondependent parental substance misuse upon children. METHODS: We searched the international literature using rigorous systematic methods to identify studies examining parental substance misuse and adverse outcomes in children. The inclusion criteria were cross-sectional, longitudinal, case-control, and cohort studies; of children aged 0-18 years whose parents are high-risk substance misusers; reporting on their health, psychological, substance use, educational, and social outcomes...
January 1, 2018: Trauma, Violence & Abuse
https://www.readbyqxmd.com/read/29736274/burden-of-physical-psychological-and-social-ill-health-during-and-after-pregnancy-among-women-in-india-pakistan-kenya-and-malawi
#9
Mary McCauley, Barbara Madaj, Sarah A White, Fiona Dickinson, Sarah Bar-Zev, Mamuda Aminu, Pamela Godia, Pratima Mittal, Shamsa Zafar, Nynke van den Broek
Introduction: For every woman who dies during pregnancy and childbirth, many more suffer ill-health, the burden of which is highest in low-resource settings. We sought to assess the extent and types of maternal morbidity. Methods: Descriptive observational cross-sectional study at primary-level and secondary-level healthcare facilities in India, Pakistan, Kenya and Malawi to assess physical, psychological and social morbidity during and after pregnancy. Sociodemographic factors, education, socioeconomic status (SES), quality of life, satisfaction with health, reported symptoms, clinical examination and laboratory investigations were assessed...
2018: BMJ Global Health
https://www.readbyqxmd.com/read/29733097/the-effects-on-patient-retention-after-opioid-weaning-in-an-internal-medicine-residency-clinic
#10
Charles P Opperman, Melissa M Butler, Andrew K Stroud, Michael R Sun
A retrospective, cross-sectional study was completed on 220 patients to determine the effects of implementation of an aggressive policy to curb opioid misuse/abuse in an internal medicine residency clinic. Our findings suggest that the development of a clear and consistent protocol for approaching patients on chronic controlled substances, as well as the initiation of regular didactic sessions addressing chronic pain and pain management, led to a dramatic reduction in the number or opioid prescriptions written by our resident providers without much reduction in patient volume...
March 2018: Journal of Opioid Management
https://www.readbyqxmd.com/read/29722031/indirect-acting-strategy-of-opioid-action-instead-of-direct-receptor-activation-dual-acting-enkephalinase-inhibitors-denkis
#11
REVIEW
R B Raffa, J V Pergolizzi, R Taylor, M H Ossipov
WHAT IS KNOWN AND OBJECTIVE: Although pain is one of the most common afflictions, it is often inadequately managed because the available analgesic options are relatively limited due to insufficient efficacy, unacceptable adverse effects or the potential for misuse or abuse. However, recent publications suggest that an alternative approach-indirect enhancement of endogenous pain-relieving pathways-might be desirable. We review this approach, in particular the dual enkephalinase inhibitors (DENKIs)...
May 2, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29721592/social-inequalities-in-mental-disorders-and-substance-misuse-in-young-adults-a-birth-cohort-study-in-southern-brazil
#12
Fernando C Barros, Alicia Matijasevich, Iná S Santos, Bernardo L Horta, Bruna Gonçalves C da Silva, Tiago N Munhoz, Seena Fazel, Alan Stein, Rebecca M Pearson, Luciana Anselmi, Luis Augusto Rohde
PURPOSE: To investigate the association between mental disorders and substance misuse at 30 years of age with gender, socioeconomic position at birth, and family income trajectories. METHODS: The 1982 Pelotas Birth Cohort was used; all 5914 children born alive at hospital were originally enrolled (99.2% of all city births). In 2012, 3701 subjects were located and interviewed (68% retention rate). Mental disorders and substance misuse were assessed, and their prevalence analysed according to gender, socioeconomic status at birth, and four different income trajectories: always poor, never poor, poor at birth/non-poor at age 30, and non-poor at birth/poor at age 30...
May 2, 2018: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/29716553/protocol-for-a-cluster-randomised-controlled-trial-evaluating-the-impact-of-a-preschool-based-capacity-building-intervention-on-intimate-partner-violence-and-substance-misuse-in-sri-lanka
#13
Kamalini Lokuge, Polly Wallace, Kalini Subasinghe, Katherine Thurber, Tissa De Silva, Naomi Clarke, Dulshika Waas, Nisansala Liyanage, Udena Attygalle, Bradley Carron-Arthur, Kalyana Rodrigo, Emily Banks, Cate D'Este, Thilini Rajapakse
BACKGROUND: Past research has identified links between intimate partner violence (IPV) and alcohol misuse and poverty in Sri Lanka. Services that address substance misuse are amongst the few interventions shown to reduce IPV in settings similar to Sri Lanka. This paper describes the protocol for a study examining the impact of a preschool-based capacity building intervention on the prevalence of IPV and substance misuse in parents with children attending preschools, including uptake of available government services...
May 2, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29716396/bridging-hospital-and-community-care-for-homeless-adults-with-mental-health-needs-outcomes-of-a-brief-interdisciplinary-intervention
#14
Vicky Stergiopoulos, Agnes Gozdzik, Rosane Nisenbaum, Janet Durbin, Stephen W Hwang, Patricia O'Campo, Joshua Tepper, Don Wasylenki
OBJECTIVE: This study examines health and service use outcomes and associated factors among homeless adults participating in a brief interdisciplinary intervention following discharge from hospital. METHOD: Using a pre-post cohort design, 223 homeless adults with mental health needs were enrolled in the Coordinated Access to Care for the Homeless (CATCH) program, a 4- to 6-month interdisciplinary intervention offering case management, peer support, access to primary psychiatric care, and supplementary community services...
January 1, 2018: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/29702199/androgen-and-estrogen-receptor-mediated-activities-of-4-hydroxytestosterone-4-hydroxyandrostenedione-and-their-human-metabolites-in-yeast-based-assays
#15
Annekathrin Martina Keiler, Oliver Zierau, Sylvi Wolf, Patrick Diel, Wilhelm Schänzer, Günter Vollmer, David Machalz, Gerhard Wolber, Maria Kristina Parr
4-Hydroxyandrost-4-ene-3,17-dione, also named formestane, is an irreversible aromatase inhibitor and therapeutically used as anti-breast cancer medication in post-menopausal women. Currently, no therapeutical indication led to approval of its 17-hydroxylated analog 4-hydroxytestosterone, an anabolic steroid. However, it is currently investigated in a clinical trial for breast cancer. In context with sports doping, aromatase inhibitors are administered to reduce estrogenic side effects of misused anabolic substances or their metabolites...
April 24, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29701148/quantification-of-methamphetamine-%C3%A2-shabu%C3%A2-in-biological-matrices-to-detect-prenatal-exposure-a-case-report-and-a-literature-review
#16
Pilar Jarque, Antonia Roca, Isabel Gomila, Valeria Noce, B Bernardino Barcelo, Julia Klein
BACKGROUND: Methamphetamine misuse represents an increasing global public health problem. Its consumption during pregnancy becomes a relevant issue, since it has clinical consequences for the child's health and the pregnant woman. Despite this, there are only few data in the literature that include analytical results in the matrices used to detect prenatal exposure. OBJECTIVES: 1) Present a case report of prenatal methamphetamine exposure with toxicological analytical confirmation in biological matrices; and 2) Perform a compilation of prenatal methamphetamine exposure studies and case reports which include toxicological analytical results...
April 26, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29700904/trajectories-of-dispensed-prescription-opioids-among-beneficiaries-enrolled-in-a-medicaid-controlled-substance-lock-in-program
#17
Rebecca B Naumann, Stephen W Marshall, Nisha C Gottfredson, Jennifer L Lund, Christopher L Ringwalt, Asheley C Skinner
PURPOSE: "Lock-in" programs (LIPs) are used by health insurers to address potential substance (eg, opioid) misuse among beneficiaries. We sought to (1) examine heterogeneity in trajectories of dispensed opioids (in average daily morphine milligram equivalents (MMEs)) over time: prior to, during, and following release from a LIP, and (2) assess associations between trajectory patterns and beneficiary characteristics. METHODS: Medicaid claims were linked to Prescription Drug Monitoring Program records for a cohort of beneficiaries enrolled in the North Carolina Medicaid LIP (n = 2701)...
April 26, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29699529/substance-use-and-suicidal-ideation-and-behaviour-in-low-and-middle-income-countries-a-systematic-review
#18
Elsie Breet, Daniel Goldstone, Jason Bantjes
BACKGROUND: Understanding relationships between substance use and suicidal ideation and behaviour (SIB) has important public health implications for suicide prevention in low- and middle-income countries (LMICs), where 75% of suicides occur. This systematic review explored the associations between substance use and SIB in LMICs. METHODS: We searched five databases using a combination of keywords for substance use, SIB and LMICs to identify English-written quantitative studies published between January 2006 and February 2016...
April 24, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29687539/using-prescription-claims-to-detect-aberrant-behaviors-with-opioids-comparison-and-validation-of-5-algorithms
#19
Kathryn Rough, Krista F Huybrechts, Sonia Hernandez-Diaz, Rishi J Desai, Elisabetta Patorno, Brian T Bateman
OBJECTIVE: Compare and validate 5 algorithms to detect aberrant behavior with opioids: Opioid Misuse Score, Controlled Substance-Patterns of Utilization Requiring Evaluation (CS-PURE), Overutilization Monitoring System, Katz, and Cepeda algorithms. STUDY DESIGN AND SETTING: We identified new prescription opioid users from 2 insurance databases: Medicaid (2000-2006) and Clinformatics Data Mart (CDM; 2004-2013). Patients were followed 1 year, and aberrant opioid behavior was defined according to each algorithm, using Cohen's kappa to assess agreement...
April 24, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29683021/family-focused-practice-for-families-affected-by-maternal-mental-illness-and-substance-misuse-in-home-visiting-a-qualitative-systematic-review
#20
Rachel A Leonard, Mark Linden, Anne Grant
Maternal mental illness is a major public health issue and can adversely affect the whole family. Increasingly, research and policy are recognizing the benefits of a family-focused approach to practice, an approach that emphasizes the family as the unit of care. This review was conducted with the aim of systematically analyzing the qualitative literature surrounding health visitors' family-focused practice with mothers who have mental illness and/or substance misuse. Through the synthesis, we developed three main findings: (a) parents' needs regarding health visitors' family-focused practice, (b) the ambiguity of mental illness in health visiting, and (c) the challenges of family-focused practice in health visiting...
April 1, 2018: Journal of Family Nursing
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