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Substance misuse

Narges Pachenari, Hossein Azizi, Elmira Ghasemi, Maryam Azadi, Saeed Semnanian
During the past decades, the use/misuse of opioids has increased dramatically among adolescent population. It is now well acknowledged that various morphological and physiological changes occur in the brain during adolescence. During this critical period, brain development and maturation could be affected by several factors including stress, drug abuse, nutritional status, etc. Although studies on transgenerational effects of substances such as alcohol, nicotine, and cocaine have focused on both paternal and maternal drug exposure, most reports on transgenerational effects of morphine are restricted to maternal exposure...
April 2018: Behavioural Pharmacology
Natalie Colaneri, Mark Sheldon, Andrew Adesman
PURPOSE OF REVIEW: Given the pervasiveness of psychotropic medication in the youth population and an increasingly competitive culture regarding educational performance, children, teenagers, and/or their parents may increasingly seek psychotropic substances in an effort to enhance a student's cognitive abilities and/or academic performance. Physicians must become aware of this very important and clinically relevant issue and work to ensure that medications remain in the hands of patients seeking wellness and not enhancement...
March 13, 2018: Current Opinion in Pediatrics
Kamilla L Venner, Victoria Sánchez, Jacqueline Garcia, Robert L Williams, Andrew L Sussman
PURPOSE: Rates of risky substance use and substance use disorders are high in primary-care practices, yet the adoption of universal screening and brief intervention (SBI) has been slow and uneven. This study aimed to describe SBI-related attitudes, practices, and perspectives regarding practice change among medical providers in a minority-majority state. METHODS: We conducted a cross-sectional, on-line survey of a practice-based research network of medical providers serving predominantly Hispanic/Latinx and Native American patients in rural and urban settings...
March 2018: Journal of the American Board of Family Medicine: JABFM
Catherine L Ward, Lillian Artz, Lezanne Leoschut, Reshma Kassanjee, Patrick Burton
BACKGROUND: We aimed to complete a nationally representative study of sexual violence against children in South Africa, and its correlates, since we could identify no other such study. METHODS: For this nationally representative, cross-sectional study in South Africa, households were selected by use of a multistage sampling frame, stratified by province, urban or rural setting, and race group, and schools were selected on the basis that they were closest to the area in which households were selected...
April 2018: Lancet Global Health
Kirsti Haracz, Michael Hazelton, Carole James
High levels of lifestyle risk factors compound medication side effects, resulting in high rates of obesity among people with schizophrenia spectrum disorders (SSDs). Obesity and related comorbidities increase the levels of disability and disadvantage in this population. Little research has explored the lived experiences in relation to this issue, and less has considered the experiences of women. Our aim in this study was to understand the experiences of women who gained weight after their diagnosis and treatment for SSDs...
March 9, 2018: Journal of Nervous and Mental Disease
Lorenzo Lorenzo-Luaces, Mark Zimmerman, Pim Cuijpers
BACKGROUND: The generalizability of findings from studies exploring the efficacy of psychotherapy and antidepressants has been called into question in part because studies exclude many patients. Despite this, the frequency with which psychotherapy and antidepressant studies use specific inclusion and exclusion criteria has never been compared. We explored the exclusion criteria used in psychotherapy and pharmacotherapy studies from 1995 to 2014. METHOD: Systematic literature searches were conducted in PubMed, Medline, PsycINFO, and Embase of published randomized controlled trials (RCTs) of the treatment of major depressive disorder (MDD) in adults with either antidepressants (vs...
February 27, 2018: Journal of Affective Disorders
Jacqui Thornton
No abstract text is available yet for this article.
March 7, 2018: BMJ: British Medical Journal
Christopher J Mehus, Jennifer Doty, Gary Chan, Adrian B Kelly, Sheryl Hemphill, John Toumbourou, Barbara J McMorris
BACKGROUND: Parents and peers both influence the development of adolescent substance misuse, and the Social Interaction Learning (SIL) model provides a theoretical explanation of the paths through which this occurs. OBJECTIVE: The SIL model has primarily been tested with conduct outcomes and in US samples. This study adds to the literature by testing the SIL model with four substance use outcomes in a sample of Australian youth. METHOD: We used structural equation modeling to test the fit of the SIL model to a longitudinal sample (n = 907) of students recruited in grade 5 in Victoria, Australia participating in the International Youth Development Study, who were resurveyed in grades 6 and 10...
March 6, 2018: Substance Use & Misuse
Smita Bakhai, Bright Thilagar, Jessica L Reynolds, Kenneth E Leonard
OBJECTIVE: Determine correlates of opiate misuse based on urine drug test (UDT) among patients on chronic opiate therapy (COT) for chronic noncancer pain. DESIGN: A cross-sectional study. SETTING: Urban, academic clinic. PARTICIPANTS: UDT performed in 206 patients on COT for at least 3 months duration within a one-year period. Patients were classified based on UDT results: (1) Appearance of Opiate Adherence: Positive UDT for prescribed opiate and negative for illicit drugs and nonprescribed control substances; (2) Opiate Misuse; Overt nonadherence: (a) Positive UDT for illicit drugs and/or nonprescribed controlled substances AND positive or negative for prescribed opiates (b) Overdose; (3) Possible opiate nonadherence: Negative for prescribed opiates and negative for illicit and nonprescribed controlled substances...
January 2018: Journal of Opioid Management
Julie Bruneau, Keith Ahamad, Marie-Ève Goyer, Ginette Poulin, Peter Selby, Benedikt Fischer, T Cameron Wild, Evan Wood
No abstract text is available yet for this article.
March 5, 2018: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
Cynthia R Pearson, Lucy Smartlowit-Briggs, Annie Belcourt, Michele Bedard-Gilligan, Debra Kaysen
OBJECTIVES: To describe our partnership and research infrastructure development strategies and discuss steps in developing a culturally grounded framework to obtain data and identify a trauma-informed evidence-based intervention. METHOD: We present funding strategies that develop and maintain the partnership and tools that guided research development. We share how a community research committee was formed and the steps taken to clarify the health concern and develop a culturally tailored framework...
March 1, 2018: Health Promotion Practice
Else Guthrie, Mathew Harrison, Richard Brown, Rajdeep Sandhu, Peter Trigwell, Seri Abraham, Shazada Nawaz, Peter Kelsall, Rachel Thomasson
Aims and method To develop and pilot a clinician-rated outcome scale to evaluate symptomatic outcomes in liaison psychiatry services. Three hundred and sixty patient contacts with 207 separate individuals were rated using six subscales (mood, psychosis, cognition, substance misuse, mind-body problems and behavioural disturbance) plus two additional items (side-effects of medication and capacity to consent for medical treatment). Each item was rated on a five-point scale from 0 to 5 (nil, mild, moderate, severe and very severe)...
March 4, 2018: BJPsych Bulletin
Amit Garg, Vassiliki Papagermanos, Margaretta Midura, Andrew Strunk, Jonathan Merson
BACKGROUND: Patients with hidradenitis suppurativa (HS) experience chronic pain and have significant physical, emotional and psychological disease impact. These patients may be at risk for substance abuse. OBJECTIVE: To evaluate substance use disorder (SUD) among HS patients in the United States. METHODS: Cross-sectional analysis of adult HS patients (n = 32,625) identified using electronic health records data from a population-based sample of over 50 million patients...
February 27, 2018: Journal of the American Academy of Dermatology
Judith A Paice
Cancer pain remains a feared consequence of the disease and its treatment. Although prevalent, cancer pain can usually be managed through the skillful application of pharmacologic and nonpharmacologic interventions. Unfortunately, access to these therapies has been hampered by interventions designed to contain another serious public health problem: the opioid misuse epidemic. This epidemic and the unintended consequences of efforts to control this outbreak are leading to significant barriers to the provision of cancer pain relief...
March 2, 2018: Cancer
Richard Stansfield
BACKGROUND: Religious beliefs and practices have been shown to have some association with desistance from offending, as have cognitive processes, including emotion regulation, self-control, reasoning, learning, and empathy. Religious behaviours may, however, be moderated or mediated by cognitive abilities, but few studies take this into account. AIM: The aim of this study was to assess the role of cognitive ability in any relationship between religious beliefs and behaviours and desistance from substance use among adolescents...
March 1, 2018: Criminal Behaviour and Mental Health: CBMH
Janusz Springer, Wiesław Jerzy Cubała
Tianeptine is an atypical antidepressant approved in 25 countries for the treatment of depressive syndromes. Tianeptine abuse among psychiatric patients in the community and at inpatient wards has been increasingly reported in recent years. The purpose of this article is to alert clinicians to tianeptine abuse potential and identify any patterns in the literature. We searched the Academic Search Complete, Google Scholar, MEDLINE, Science Citation Index, Scopus, and the Social Sciences Citation Index for articles published between 1960-2017 in any language containing the keywords: "tianeptine abuse," "tianeptine misuse," "tianeptine dependence...
March 1, 2018: Journal of Psychoactive Drugs
Martin J Downing, Dominique Brown, Jeffrey Steen, Ellen Benoit
BACKGROUND: Childhood sexual abuse (CSA) remains a critical public health issue among black and Latino men who have sex with men (MSM), as it is associated with multiple negative outcomes including substance misuse, poor mental health, revictimization, and high-risk sexual behavior. Most CSA research with MSM relies on quantitative assessment that often precludes consideration of cultural variations in how formative sexual experiences are understood and is based on inconsistent or overly restrictive definitions of abuse, and therefore may fail to detect certain abusive experiences (eg, those involving female perpetrators), which can have harmful health consequences if they remain unrecognized...
February 26, 2018: JMIR Research Protocols
Eva Tedgård, Maria Råstam, Ingegerd Wirtberg
AIM: To add to our knowledge concerning the key elements involved in the individual's experience of growing up with substance abusing parents and the resulting challenges this involved for their own parenthood. METHODS: In-depth interviews were conducted with 19 parents who had participated in a mental health intervention programme. All had experienced substance abusing parents in their family of origin. Qualitative content analysis was used to analyse the data...
December 2018: International Journal of Qualitative Studies on Health and Well-being
Andrew H Rogers, Jafar Bakhshaie, Hantin Lam, Kirsten J Langdon, Joseph W Ditre, Michael J Zvolensky
Pain problems are of significant public health concern, and with opioid-related problems and death due to overdose at an all-time high, there is significant public health importance to identify risk factors that link instances of pain to opioid misuse among persons with pain whether or not they have been prescribed opioids for pain management. Severe pain and pain-related problems have been associated with increased risk for opioid misuse, and recent research indicates that pain-related anxiety (worry about the negative consequences of pain) may contribute to a more debilitating pain experience...
February 26, 2018: Cognitive Behaviour Therapy
Anthony G Phillips, Mark A Geyer, Trevor W Robbins
Athina Markou and others argue forcefully for the adoption of a "translational-back translational strategy" for central nervous system drug discovery involving novel application of drugs with established safety profiles in proof-of-principle studies in humans, which in turn encourage parallel studies using experimental animals to provide vital data on the neural systems and neuropharmacological mechanisms related to the actions of the candidate drugs. Encouraged by the increasing adoption of drug-development strategies involving reciprocal information exchange between preclinical animal studies and related clinical research programs, this review presents additional compelling examples related to the following: 1) the treatment of cognitive deficits that define attention-deficit/hyperactivity disorder; 2) the development of fast-acting antidepressants based on promising clinical effects with low doses of the anesthetic ketamine; and 3) new and effective medications for the treatment of substance misuse...
January 31, 2018: Biological Psychiatry
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