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https://www.readbyqxmd.com/read/29621921/temporal-and-quantitative-associations-of-electronic-fetal-heart-rate-monitoring-patterns-and-neonatal-outcomes-%C3%A2
#1
Dotun Ogunyemi, Andrew Jovanovski, Perry Friedman, Brittany Sweatman, Ichchha Madan
OBJECTIVE: The objective of this study is to evaluate the associations of electronic fetal heart rate monitoring (EFM) patterns and adverse neonatal outcomes Study design: From 2013 to 2016; 12,067 term, singleton deliveries in labor ≥2 h with abnormal EFM defined as absent accelerations, variable, late or prolonged decelerations, tachycardia, bradycardia, or minimal variability were analyzed as any documentation during labor, in first hour and last hour of labor. Outcomes were composite neonatal adverse outcomes, neonatal intensive care unit (NICU) admission, neonatal hypoxia, neonatal hypoglycemia, umbilical artery pH, and base excess...
April 6, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29614446/intrapartum-and-perinatal-results-associated-with-different-degrees-of-staining-of-meconium-stained-amniotic-fluid
#2
Vanesa Rodríguez Fernández, Carlos Nicolás López Ramón Y Cajal, Elena Marín Ortiz, Emilio Couceiro Naveira
OBJECTIVE: To determine the intrapartum and perinatal results associated with different degrees of staining of meconium stained amniotic fluid (MSAF). STUDY DESIGN: In a retrospective cohort study of all singleton deliveries over a period of one year (2015) in a tertiary hospital, we compared different degrees of MSAF (yellow, green and thick) to clear amniotic fluids, and analysed in each group maternal, intrapartum and neonatal variables as well as umbilical cord blood gas analysis...
March 19, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29607557/maternal-hemodynamics-fetal-biometry-and-dopplers-in-pregnancies-followed-up-for-suspected-fetal-growth-restriction
#3
Llinos A Roberts, Hua Zen Ling, Liona Poon, Kypros H Nicolaides, Nikos A Kametas
OBJECTIVES: To assess whether in a cohort of patients with small for gestational age (SGA) foetuses with estimated fetal weight ≤10th percentile, maternal hemodynamics, fetal biometry and Dopplers at presentation, can predict the subsequent development of abnormal fetal Dopplers or delivery with birthweight <3rd percentile. METHODS: The study population comprised of 86 singleton pregnancies with SGA fetuses presenting at a median gestational age of 32 (range 26-35) weeks...
April 1, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29607458/impact-of-high-magnification-sperm-selection-on-neonatal-outcomes-a-retrospective-study
#4
Olivier Gaspard, Pierre Vanderzwalmen, Barbara Wirleitner, Stéphanie Ravet, Frédéric Wenders, Verena Eichel, Alice Mocková, Dietmar Spitzer, Caroline Jouan, Virginie Gridelet, Henri Martens, Laurie Henry, Herbert Zech, Sophie Perrier d'Hauterive, Michelle Nisolle
PURPOSE: The aim of this study was to compare the effect of the deselection of spermatozoa presenting vacuole-like structures using IMSI (intracytoplasmic morphologically selected sperm injection) with ICSI (intracytoplasmic sperm injection) by means of neonatal outcomes. METHODS: In a retrospective two-center analysis, a total of 848 successful IMSI or ICSI cycles ending with a live birth, induced abortion, or intrauterine fetal death (IUFD) were included. RESULTS: The IMSI and ICSI groups included 332 and 655 babies or fetuses, respectively...
April 2, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29604064/altered-autonomic-control-of-heart-rate-variability-in-the-chronically-hypoxic-fetus
#5
C J Shaw, B J Allison, N Itani, K J Botting, Y Niu, C C Lees, D A Giussani
Although fetal heart rate variability (FHRV) has long been recognised as a powerful predictor of fetal wellbeing, the mechanisms by which it is reduced in the chronically hypoxic fetus have yet to be established. In particular, the physiological mechanism underlying the reduction of short term variation (STV) in fetal compromise remains unclear. In this study, we present a longitudinal study of the development of autonomic control of FHRV, assessed by indirect indices, time domain (SDNN, RMSSD) and power spectral analysis (LF, HF, LF/HF), in normoxic and chronically hypoxic, chronically catheterised, singleton fetal sheep over the last third of gestation...
March 31, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29604062/saving-the-brain-one-heartbeat-at-a-time
#6
Martin G Frasch
In their article "Evolving changes in fetal heart rate variability and brain injury after hypoxia-ischemia in preterm fetal sheep," Dr. Yamaguchi et al. set out to demonstrate the time course of changes in several widely-used heart rate variability (HRV) measures during an exposure to a hypoxic-ischemic (HI) insult using fetal sheep as a model. This article is protected by copyright. All rights reserved.
March 31, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29595875/impaired-autonomic-function-in-adolescents-born-preterm
#7
Kristin Haraldsdottir, Andrew M Watson, Kara N Goss, Arij G Beshish, David F Pegelow, Mari Palta, Laura H Tetri, Gregory P Barton, Melissa D Brix, Ryan M Centanni, Marlowe W Eldridge
Preterm birth temporarily disrupts autonomic nervous system (ANS) development, and the long-term impacts of disrupted fetal development are unclear in children. Abnormal cardiac ANS function is associated with worse health outcomes, and has been identified as a risk factor for cardiovascular disease. We used heart rate variability (HRV) in the time domain (standard deviation of RR intervals, SDRR; and root means squared of successive differences, RMSSD) and frequency domain (high frequency, HF; and low frequency, LF) at rest, as well as heart rate recovery (HRR) following maximal exercise, to assess autonomic function in adolescent children born preterm...
March 2018: Physiological Reports
https://www.readbyqxmd.com/read/29595529/ec50-of-epidural-ropivacaine-combined-with-dexmedetomidine-for-labor-analgesia
#8
Wp Zhang, Cuiling Li
BACKGROUND: It was reported that the optimal concentration of epidural dexmedetomidine for labor analgesia was 0.5▒ug/mL when combined with 0.1% ropivacaine. This study investigated the median effective concentration (EC50) of epidural ropivacaine for labor analgesia when combined with 0.5▒ug/mL dexmedetomidine. METHODS: Sixty full-term primiparas were enrolled and divided into two groups in this prospective study. Group D received 10▒mL solution (ropivacaine + 0...
March 27, 2018: Clinical Journal of Pain
https://www.readbyqxmd.com/read/29594003/snake-bite-in-third-trimester-of-pregnancy-with-systemic-envenomation-and-delivery-of-a-live-baby-in-a-low-resource-setting-a-case-report
#9
Adebayo A Adewole, Osadolor A Ugiagbe, Temitope G Onile, Gabriel A Joseph, Oluwamayowa D Kassim, Patricia F Medupin, Abiodun S Adeniran
Background: Snake bite in the third trimester of pregnancy with late presentation, systemic envenomation; disseminated intravascular coagulopathy and delivery of a live neonate is uncommon in a low resource setting. Case: We present a 22 year old unbooked Gravida 3 Para 1+ 1 1alive lentiviral positive woman at 32 weeks gestation with snake bite, leg swelling, vaginal bleeding and labour pains. At presentation, there were anemia, tachycardia, hypotension; a gravid uterus with a single fetus in longitudinal lie, cephalic presentation, regular fetal heart rate and cervical dilatation of 3 cm...
October 2017: Case Reports in Women's Health
https://www.readbyqxmd.com/read/29587562/correlation-between-umbilical-arterial-ph-values-and-fetal-vertebral-artery-doppler-waveforms-at-the-beginning-of-the-second-stage-of-labor-a-pilot-prospective-study
#10
Danila Morano, Gennaro Scutiero, Piergiorgio Iannone, Giulia Nencini, Elena Mantovani, Antonio Farina, Pantaleo Greco
OBJECTIVE: The aim of this study was to evaluate the association between umbilical arterial pH and fetal vertebral artery Doppler velocimetry waveforms measured at the beginning of the second stage of labor in physiological term pregnancies. METHODS: This was a prospective cohort study of 250 pregnancies. The resistance index, pulsatility index and peak systolic velocity were measured. The relationship between the fetal Doppler and the umbilical arterial pH was evaluated...
March 27, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29582422/the-effect-of-spinal-hyperbaric-bupivacaine-fentanyl-or-hyperbaric-bupivacaine-on-uterine-tone-and-fetal-heart-rate-in-labouring-women-a-randomised-controlled-study
#11
A Kuberan, K Jain, R Bagga, J K Makkar
The mechanism for fetal heart rate abnormalities following spinal opioids remains controversial. We evaluated uterine tone, using an intra-uterine pressure catheter, and fetal heart rate abnormalities in 30 women in spontaneous labour with cervical dilation of 3-5 cm having combined spinal-epidural analgesia. Women were randomly assigned to receive a spinal with 2.0 mg hyperbaric bupivacaine plus 15 μg fentanyl, or 2.5 mg hyperbaric bupivacaine. The primary outcome measure was an increase > 10 mmHg in baseline uterine tone in the 30-min period following spinal injection...
March 26, 2018: Anaesthesia
https://www.readbyqxmd.com/read/29582244/a-comparison-of-five-algorithms-for-fetal-magnetocardiography-signal-extraction
#12
Diana Escalona-Vargas, Hau-Tieng Wu, Martin G Frasch, Hari Eswaran
Fetal magnetocardiography (fMCG) provides accurate and reliable measurements of electrophysiological events in the fetal heart and is capable of studying fetuses with congenital heart diseases. A variety of techniques exist to extract the fMCG signal with the demand for non-invasively obtained fetal cardiac information. To the best of our knowledge, there is no comparative study published in the field as to how the various extraction algorithms perform. We perform a comparative study of the ability of five methods to extract the fMCG using real biomagnetic signals, two of those methods are applied to real fMCG data for the first time...
March 26, 2018: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/29577914/the-importance-of-the-learning-process-in-st-analysis-interpretation-and-its-impact-in-improving-clinical-and-neonatal-outcomes
#13
Susanna Timonen, Kaisa Holmberg
BACKGROUND: Intrapartum fetal heart rate (FHR) monitoring was introduced with the goal to reduce fetal hypoxia and deaths. However, continuous FHR monitoring has been shown to have a high sensitivity but also a high false positive rate. To improve specificity, adjunctive technologies have been developed to identify fetuses at risk for intrapartum asphyxia. Intensive research on the value of ST-segment analysis of the fetal electrocardiogram (ECG) as an adjunct to standard electronic fetal monitoring (EFM) in lowering the rates of fetal metabolic acidosis and operative deliveries has been ongoing...
March 22, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29575562/an-evaluation-of-fetal-heart-rate-characteristics-associated-with-neonatal-encephalopathy-a-case-control-study
#14
Heather A Frey, Xiaohua Liu, Courtney D Lynch, Wanjiku Musindi, Philip Samuels, Kara M Rood, Stephen F Thung, Juliana M Bakk, Weiwei Cheng, Mark B Landon
OBJECTIVE: We sought to identify fetal heart rate (FHR) characteristics that are associated with neonatal encephalopathy (NE). DESIGN: Retrospective case-control study. SETTING: A single medical center in Shanghai, China, 2006-2015. SAMPLE: Women delivering a singleton, non-anomalous infant at ≥36 weeks gestation diagnosed with NE (cases, n=109) were compared to a group of women with unaffected infants (controls, n=233)...
March 25, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29572752/development-of-a-smart-mobile-data-module-for-fetal-monitoring-in-e-healthcare
#15
Agathe Houzé de l'Aulnoit, Samuel Boudet, Michaël Génin, Pierre-François Gautier, Jessica Schiro, Denis Houzé de l'Aulnoit, Régis Beuscart
The fetal heart rate (FHR) is a marker of fetal well-being in utero (when monitoring maternal and/or fetal pathologies) and during labor. Here, we developed a smart mobile data module for the remote acquisition and transmission (via a Wi-Fi or 4G connection) of FHR recordings, together with a web-based viewer for displaying the FHR datasets on a computer, smartphone or tablet. In order to define the features required by users, we modelled the fetal monitoring procedure (in home and hospital settings) via semi-structured interviews with midwives and obstetricians...
March 23, 2018: Journal of Medical Systems
https://www.readbyqxmd.com/read/29568912/clinical-study-of-prenatal-ultrasonography-combined-with-t%C3%A2-box-transcription-factor-1-as-a-biomarker-for-the-diagnosis-of-congenital-heart-disease
#16
Bingcheng Guo, Jing Xiao, Long Li, Shuanglong Wang, Lijuan Wang, Shuyong Liu
Congenital heart disease (CHD) seriously threatens fetal health. Therefore, prenatal examination to detect deformity is extremely important. The present study aimed to investigate the clinical application value of prenatal ultrasonography combined with molecular biology methods in the diagnosis of fetal CHD. A total of 1,000 pregnant women who had received fetal ultrasonography to examine fetal CHD were enrolled. Ultrasounds were performed for fetal heart examination and diagnosis, mainly on fetal heart position, size, structure and function, and heart valve morphology and function...
March 14, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29550788/recovery-of-signal-loss-adopting-the-residual-bootstrap-method-in-fetal-heart-rate-dynamics
#17
Sun-Kyung Lee, Young-Sun Park, Kyung-Joon Cha
Fetal heart rate (FHR) data obtained from a non-stress test (NST) can be presented in a type of time series, which is accompanied by signal loss due to physical and biological causes. To recover or estimate FHR data, which is subjected to a high rate of signal loss, time series models [second-order autoregressive (AR(2)), first-order autoregressive conditional heteroscedasticity (ARCH(1)) and empirical mode decomposition and vector autoregressive (EMD-VAR)] and the residual bootstrap method were applied. The ARCH(1) model with the residual bootstrap technique was the most accurate [root mean square error (RMSE), 2...
March 19, 2018: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/29544375/obstetric-and-perinatal-outcomes-in-pregnancies-with-isolated-fetal-congenital-heart-abnormalities
#18
Cathy Liu, Jade Lodge, Christopher Flatley, Alexander Gooi, Cameron Ward, Karen Eagleson, Sailesh Kumar
OBJECTIVE: To determine obstetric, intrapartum and perinatal outcomes for pregnancies with isolated fetal congenital heart defects (CHD). METHODS: This was a retrospective cohort study of women that delivered an infant with an isolated major CHD between January 2010 and April 2017 at a major Australian perinatal centre. The study cohort was compared with a cohort of women with infants without CHD. Cardiac abnormalities were broadly subdivided into the following five categories using the International Classification of Diseases Tenth Revision (ICD-10) as a guide - transposition of the great arteries (TGA), septal defects, right heart lesions (RHL), left heart lesions (LHL) and "other"...
March 16, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29536580/clinical-application-of-targeted-next-generation-sequencing-on-fetuses-with-congenital-heart-defects
#19
Ping Hu, Fengchang Qiao, Yan Wang, Lulu Meng, Xiuqing Ji, Chunyu Luo, Tianhui Xu, Ran Zhou, Jingjing Zhang, Bin Yu, Leilei Wang, Ting Wang, Qiong Pan, Dingyuan Ma, Dong Liang, Zhengfeng Xu
OBJECTIVES: This study aimed to determine the diagnostic yield of targeted next-generation sequencing (NGS) in prenatal diagnosis of congenital heart defects (CHDs) and for investigating the possible genetic etiology of prenatal CHD cases. METHODS: Forty-four fetuses with CHDs and normal molecular karyotypes underwent targeted NGS in this study. Fetal genomic DNA was directly extracted from amniotic fluid cells in each prenatal case. A customized targeted NGS panel containing 77 CHD-associated genes was designed to detect variants in the coding regions and the splicing sites of these genes...
March 13, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29534636/maternal-and-fetal-effects-of-chocolate-consumption-during-pregnancy-a-systematic-review
#20
Rabia Latif
OBJECTIVES: The purpose of this review is to explore the effects of chocolate consumption during pregnancy on fetus and mother herself. METHODS: Randomized controlled trials/quasi-experimental/observational/controlled before and after studies involving chocolate/cocoa/cacao consumption (irrespective of type or dose, composition, exposure period, and method of administration) among pregnant women/animals; and measuring any outcome (beneficial or harmful) related to fetus or mother after chocolate exposure were included...
March 13, 2018: Journal of Maternal-fetal & Neonatal Medicine
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