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green tea and anxiety

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https://www.readbyqxmd.com/read/28588748/camellia-sinensis-prevents-perinatal-nicotine-induced-neurobehavioral-alterations-tissue-injury-and-oxidative-stress-in-male-and-female-mice-newborns
#1
Jamaan S Ajarem, Gadh Al-Basher, Ahmed A Allam, Ayman M Mahmoud
Nicotine exposure during pregnancy induces oxidative stress and leads to behavioral alterations in early childhood and young adulthood. The current study aimed to investigate the possible protective effects of green tea (Camellia sinensis) against perinatal nicotine-induced behavioral alterations and oxidative stress in mice newborns. Pregnant mice received 50 mg/kg C. sinensis on gestational day 1 (PD1) to postnatal day 15 (D15) and were subcutaneously injected with 0.25 mg/kg nicotine from PD12 to D15...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28569203/neurobehavioral-changes-in-mice-offspring-exposed-to-green-tea-during-fetal-and-early-postnatal-development
#2
Jamaan Ajarem, Gawaher Al Rashedi, Mohamed Mohany, Ahmed Allam
BACKGROUND: Green tea extract (GTE) has various health promoting effects on animals and humans. However, the effects of perinatal exposure to GTE on the behavioral aspects of offspring have not been elucidated thus far. GTE was provided for pregnant female mice at concentrations of either 20 or 50 g/L, beginning the day of conception until the third week after delivery, postnatal day 22 (PD 22). Mice pups were subjected to behavioral testing to assess sensory motor reflexes, locomotion, anxiety, and learning on various postnatal days...
June 1, 2017: Behavioral and Brain Functions: BBF
https://www.readbyqxmd.com/read/28566632/anti-stress-effect-of-green-tea-with-lowered-caffeine-on-humans-a-pilot-study
#3
Keiko Unno, Hiroshi Yamada, Kazuaki Iguchi, Hitoshi Ishida, Yasunori Iwao, Akio Morita, Yoriyuki Nakamura
Theanine, an amino acid in tea, has significant anti-stress effects on animals and humans. However, the effect of theanine was blocked by caffeine and gallate-type catechins, which are the main components in tea. We examined the anti-stress effect of green tea with lowered caffeine, low-caffeine green tea, on humans. The study design was a single-blind group comparison and participants (n=20) were randomly assigned to low-caffeine or placebo tea groups. These teas (≥500 mL/d), which were eluted with room temperature water, were taken from 1 week prior to pharmacy practice and continued for 10 d in the practice period...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28448076/tea-consumption-and-health-related-quality-of-life-in-older-adults
#4
C-W Pan, Q Ma, H-P Sun, Y Xu, N Luo, P Wang
BACKGROUND: Although tea consumption has been reported to have various health benefits in humans, its association with health-related quality of life (HRQOL) has not been investigated directly. We aimed to examine the relationship between tea consumption and HRQOL among older Chinese adults. METHODS: We analyzed community-based cross-sectional data of 5,557 older Chinese individuals aged 60 years or older who participated in the Weitang Geriatric Diseases study...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28377597/dyrk1a-overexpression-leads-to-increase-of-3r-tau-expression-and-cognitive-deficits-in-ts65dn-down-syndrome-mice
#5
Xiaomin Yin, Nana Jin, Jianhua Shi, Yanchong Zhang, Yue Wu, Cheng-Xin Gong, Khalid Iqbal, Fei Liu
Alternative splicing of tau exon 10 generates tau isoforms with three or four microtubule-binding repeats, 3R-tau and 4R-tau, which is equally expressed in adult human brain. Imbalanced expression in 3R-tau and 4R-tau has been found in several sporadic and inherited tauopathies, suggesting that dysregulation of tau exon 10 is sufficient to cause neurodegenerative diseases. We previously reported that Dyrk1A, which is overexpressed in Down syndrome brains, regulates alternative splicing of exogenous tau exon 10...
April 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28181675/a-placebo-controlled-double-blinded-randomized-pilot-study-of-combination-phytotherapy-in-biochemically-recurrent-prostate-cancer
#6
M Diana van Die, Scott G Williams, Jon Emery, Kerry M Bone, Jeremy M G Taylor, Elizabeth Lusk, Marie V Pirotta
BACKGROUND: Men with biochemical recurrence of prostate cancer following local therapies often use natural supplements in an attempt to delay metastases and/or avoid the need for more aggressive treatments with undesirable side-effects. While there is a growing body of research into phytotherapeutic agents in this cohort, with some promising results, as yet no definitive recommendations can be made. This pilot study was undertaken to assess the feasibility of a fully-powered study to examine the effects of this phytotherapeutic intervention (containing turmeric, resveratrol, green tea and broccoli sprouts) on PSA doubling time in men with biochemical recurrence with a moderate PSA rise rate...
May 2017: Prostate
https://www.readbyqxmd.com/read/27396868/effects-of-chronic-l-theanine-administration-in-patients-with-major-depressive-disorder-an-open-label-study
#7
Shinsuke Hidese, Miho Ota, Chisato Wakabayashi, Takamasa Noda, Hayato Ozawa, Tsutomu Okubo, Hiroshi Kunugi
OBJECTIVE: l-theanine, an amino acid uniquely contained in green tea (Camellia sinensis), has been suggested to have various psychotropic effects. This study aimed to examine whether l-theanine is effective for patients with major depressive disorder (MDD) in an open-label clinical trial. METHODS: Subjects were 20 patients with MDD (four males; mean age: 41.0±14.1 years, 16 females; 42.9±12.0 years). l-theanine (250 mg/day) was added to the current medication of each participant for 8 weeks...
April 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/26797633/anti-stress-behavioural-and-magnetoencephalography-effects-of-an-l-theanine-based-nutrient-drink-a-randomised-double-blind-placebo-controlled-crossover-trial
#8
RANDOMIZED CONTROLLED TRIAL
David J White, Suzanne de Klerk, William Woods, Shakuntla Gondalia, Chris Noonan, Andrew B Scholey
L-theanine (γ-glutamylethylamide) is an amino acid found primarily in the green tea plant. This study explored the effects of an L-theanine-based nutrient drink on mood responses to a cognitive stressor. Additional measures included an assessment of cognitive performance and resting state alpha oscillatory activity using magnetoencephalography (MEG). Thirty-four healthy adults aged 18-40 participated in this double-blind, placebo-controlled, balanced crossover study. The primary outcome measure, subjective stress response to a multitasking cognitive stressor, was significantly reduced one hour after administration of the L-theanine drink when compared to placebo...
January 2016: Nutrients
https://www.readbyqxmd.com/read/26613119/natural-products-micronutrients-and-nutraceuticals-for-the-treatment-of-depression-a-short-review
#9
Seyed Mohammad Nabavi, Maria Daglia, Nady Braidy, Seyed Fazel Nabavi
OBJECTIVES: Depression is one of the most common psychiatric disorders, and the fourth leading cause of long-term disability throughout the world. Despite the availability of different classes of antidepressant drugs, most of them are not completely effective and above all are associated with many serious adverse effects. Recently, accumulating evidence suggests that dietary supplements rich in important phytochemicals possess beneficial therapeutic roles in depression. METHODS: In this review, we will first consider what is known about the pathogenesis of depression and discuss the need for more safe and efficacious treatment...
November 27, 2015: Nutritional Neuroscience
https://www.readbyqxmd.com/read/25936362/d-galactose-high-dose-administration-failed-to-induce-accelerated-aging-changes-in-neurogenesis-anxiety-and-spatial-memory-on-young-male-wistar-rats
#10
Armando Cardoso, Sara Magano, Francisco Marrana, José P Andrade
The model of accelerated senescence with the prolonged administration of d-galactose is used in anti-aging studies because it mimics several aging-associated alterations such as increase of oxidative stress and decline of cognition. However, there is no standardized protocol for this aging model, and recently some reports have questioned its effectiveness. To clarify this issue, we used a model of high-dose d-galactose on 1-month-old male Wistar rats and studied the hippocampus, one of the most affected brain regions...
December 2015: Rejuvenation Research
https://www.readbyqxmd.com/read/25562843/plant-derived-flavanol-epicatechin-mitigates-anxiety-in-association-with-elevated-hippocampal-monoamine-and-bdnf-levels-but-does-not-influence-pattern-separation-in-mice
#11
T P Stringer, D Guerrieri, C Vivar, H van Praag
Flavanols found in natural products such as cocoa and green tea elicit structural and biochemical changes in the hippocampus, a brain area important for mood and cognition. Here, we evaluated the outcome of daily consumption of the flavanol (-)epicatechin (4 mg per day in water) by adult male C57BL/6 mice on measures of anxiety in the elevated plus maze (EPM) and open field (OF). Furthermore, pattern separation, the ability to distinguish between closely spaced identical stimuli, considered to be mediated by the hippocampal dentate gyrus (DG), was tested using the touchscreen...
2015: Translational Psychiatry
https://www.readbyqxmd.com/read/25318545/beneficial-effects-of-dietary-egcg-and-voluntary-exercise-on-behavior-in-an-alzheimer-s-disease-mouse-model
#12
Jennifer M Walker, Diana Klakotskaia, Deepa Ajit, Gary A Weisman, W Gibson Wood, Grace Y Sun, Peter Serfozo, Agnes Simonyi, Todd R Schachtman
Alzheimer's disease (AD) is a progressive, age-dependent neurodegenerative disorder affecting specific brain regions that control memory and cognitive functions. Epidemiological studies suggest that exercise and dietary antioxidants are beneficial in reducing AD risk. To date, botanical flavonoids are consistently associated with the prevention of age-related diseases. The present study investigated the effects of 4 months of wheel-running exercise, initiated at 2-months of age, in conjunction with the effects of the green tea catechin (-)-epigallocatechin-3-gallate (EGCG) administered orally in the drinking water (50 mg/kg daily) on: (1) behavioral measures: learning and memory performance in the Barnes maze, nest building, open-field, anxiety in the light-dark box; and (2) soluble amyloid-β (Aβ) levels in the cortex and hippocampus in TgCRND8 (Tg) mice...
2015: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/25165739/effects-of-l-theanine-on-posttraumatic-stress-disorder-induced-changes-in-rat-brain-gene-expression
#13
Tomás Eduardo Ceremuga, Stephanie Martinson, Jason Washington, Robert Revels, Jessica Wojcicki, Damali Crawford, Robert Edwards, Joshua Luke Kemper, William Luke Townsend, Geno M Herron, George Allen Ceremuga, Gina Padron, Michael Bentley
Posttraumatic stress disorder (PTSD) is characterized by the occurrence of a traumatic event that is beyond the normal range of human experience. The future of PTSD treatment may specifically target the molecular mechanisms of PTSD. In the US, approximately 20% of adults report taking herbal products to treat medical illnesses. L-theanine is the amino acid in green tea primarily responsible for relaxation effects. No studies have evaluated the potential therapeutic properties of herbal medications on gene expression in PTSD...
2014: TheScientificWorldJournal
https://www.readbyqxmd.com/read/24071782/coffee-and-tea-perks-for-health-and-longevity
#14
REVIEW
Salman K Bhatti, James H O'Keefe, Carl J Lavie
PURPOSE OF REVIEW: Tea and coffee, after water, are the most commonly consumed beverages in the world and are the top sources of caffeine and antioxidant polyphenols in the American diet. The purpose of this review is to assess the health effects of chronic tea and/or coffee consumption. RECENT FINDINGS: Tea consumption, especially green tea, is associated with significantly reduced risks for stroke, diabetes and depression, and improved levels of glucose, cholesterol, abdominal obesity and blood pressure...
November 2013: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/23983989/effect-of-epigallocatechin-gallate-supplementation-in-schizophrenia-and-bipolar-disorder-an-8-week-randomized-double-blind-placebo-controlled-study
#15
Jennifer M Loftis, Clare J Wilhelm, Marilyn Huckans
OBJECTIVES: Strategies that focus on the reduction of oxidative stress and inflammation may have therapeutic benefit for the treatment of schizophrenia. This clinical trial sought to determine, in a double-blind study, whether epigallocatechin gallate (EGCG), a green tea extract, is a useful adjunct to maintenance antipsychotic medication. METHODS: Adults with schizophrenia, schizoaffective disorder or bipolar disorder who were maintained on antipsychotic and other psychotropic medications were randomized to supplemental EGCG or placebo...
February 2013: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/23883567/neurobiological-effects-of-the-green-tea-constituent-theanine-and-its-potential-role-in-the-treatment-of-psychiatric-and-neurodegenerative-disorders
#16
REVIEW
Anne L Lardner
Theanine (n-ethylglutamic acid), a non-proteinaceous amino acid component of green and black teas, has received growing attention in recent years due to its reported effects on the central nervous system. It readily crosses the blood-brain barrier where it exerts a variety of neurophysiological and pharmacological effects. Its most well-documented effect has been its apparent anxiolytic and calming effect due to its up-regulation of inhibitory neurotransmitters and possible modulation of serotonin and dopamine in selected areas...
July 2014: Nutritional Neuroscience
https://www.readbyqxmd.com/read/23627832/effects-of-ingestion-of-a-commercially-available-thermogenic-dietary-supplement-on-resting-energy-expenditure-mood-state-and-cardiovascular-measures
#17
Jordan Outlaw, Colin Wilborn, Abbie Smith, Stacie Urbina, Sara Hayward, Cliffa Foster, Shawn Wells, Rob Wildman, Lem Taylor
BACKGROUND: Increasing metabolism is a primary focus of many commercially available dietary supplements marketed to support weight management. Caffeine (e.g. anhydrous and herbal) and green tea are key ingredients in such products, augmenting resting energy expenditure (REE) and improving reported mood states (alertness, fatigue, focus, etc.). The purpose of this study was to evaluate the effects of a thermogenic dietary supplement (DBX) on REE, respiratory exchange ratio (RER), reported measures of alertness, focus, energy, concentration, fatigue, and hunger, as well as the general safety of the product based on electrocardiogram (ECG) and hemodynamic responses in habitual caffeine consumers...
2013: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/23625424/neurochemical-and-behavioral-effects-of-green-tea-camellia-sinensis-a-model-study
#18
Beenish Mirza, Huma Ikram, Sofia Bilgrami, Darakhshan Jabeen Haleem, Muhammad Abdul Haleem
Being rich in polyphenolic compounds such as flavonoids, green tea is suggested to be a potential candidate for the treatment of obesity, stress, depression, Parkinson's and other disorders. Since serotonin has an important role in the pathophysiology of these disorders, present study was designed to monitor the effects of green tea in rats. Green tea extract was provided to the male Albino Wistar rats for 5 weeks, and effects on behaviors were monitored. Results show a decrease in food intake after 5th week but not before...
May 2013: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/23107346/effects-of-l-theanine-or-caffeine-intake-on-changes-in-blood-pressure-under-physical-and-psychological-stresses
#19
RANDOMIZED CONTROLLED TRIAL
Ai Yoto, Mao Motoki, Sato Murao, Hidehiko Yokogoshi
BACKGROUND: L-theanine, an amino acid contained in green tea leaves, is known to block the binding of L-glutamic acid to glutamate receptors in the brain, and has been considered to cause anti-stress effects by inhibiting cortical neuron excitation. Both L-theanine and caffeine, which green tea contains, have been highlighted for their beneficial effects on cognition and mood. METHODS: In this study, we investigated the effects of orally administered L-theanine or caffeine on mental task performance and physiological activities under conditions of physical or psychological stress in humans...
2012: Journal of Physiological Anthropology
https://www.readbyqxmd.com/read/22935630/l-theanine-attenuates-abstinence-signs-in-morphine-dependent-rhesus-monkeys-and-elicits-anxiolytic-like-activity-in-mice
#20
Laura E Wise, Ishani D Premaratne, Thomas F Gamage, Aron H Lichtman, Larry D Hughes, Louis S Harris, Mario D Aceto
l-theanine, 2-amino-4-(ethylcarbamoyl) butyric acid, an amino acid found in green tea (Camellia sinensis), is sold in the United States as a dietary supplement to reduce stress and improve cognition and mood. The observations that l-theanine has been shown to inhibit caffeine's stimulatory effects and that caffeine produces precipitated withdrawal signs in opioid-addicted monkeys and some opioid withdrawal signs in some normal monkeys, suggest that l-theanine may suppress opioid withdrawal signs. Additionally, l-theanine produces anxiolytic effects in humans indicating that it has anti-anxiety properties...
December 2012: Pharmacology, Biochemistry, and Behavior
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