Anat Yaskolka Meir, Maria Keller, Anne Hoffmann, Ehud Rinott, Gal Tsaban, Alon Kaplan, Hila Zelicha, Tobias Hagemann, Uta Ceglarek, Berend Isermann, Ilan Shelef, Matthias Blüher, Michael Stumvoll, Jun Li, Sven-Bastian Haange, Beatrice Engelmann, Ulrike Rolle-Kampczyk, Martin von Bergen, Frank B Hu, Meir J Stampfer, Peter Kovacs, Liming Liang, Iris Shai
BACKGROUND: Epigenetic age is an estimator of biological age based on DNA methylation; its discrepancy from chronologic age warrants further investigation. We recently reported that greater polyphenol intake benefitted ectopic fats, brain function, and gut microbiota profile, corresponding with elevated urine polyphenols. The effect of polyphenol-rich dietary interventions on biological aging is yet to be determined. METHODS: We calculated different biological aging epigenetic clocks of different generations (Horvath2013, Hannum2013, Li2018, Horvath skin and blood2018, PhenoAge2018, PCGrimAge2022), their corresponding age and intrinsic age accelerations, and DunedinPACE, all based on DNA methylation (Illumina EPIC array; pre-specified secondary outcome) for 256 participants with abdominal obesity or dyslipidemia, before and after the 18-month DIRECT PLUS randomized controlled trial...
September 25, 2023: BMC Medicine