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https://www.readbyqxmd.com/read/28319106/a-systematic-review-on-the-impact-of-diabetes-mellitus-on-the-ocular-surface
#1
REVIEW
K Co Shih, K S-L Lam, L Tong
Diabetes mellitus is associated with extensive morbidity and mortality in any human community. It is well understood that the burden of diabetes is attributed to chronic progressive damage in major end-organs, but it is underappreciated that the most superficial and transparent organ affected by diabetes is the cornea. Different corneal components (epithelium, nerves, immune cells and endothelium) underpin specific systemic complications of diabetes. Just as diabetic retinopathy is a marker of more generalized microvascular disease, corneal nerve changes can predict peripheral and autonomic neuropathy, providing a window of opportunity for early treatment...
March 20, 2017: Nutrition & Diabetes
https://www.readbyqxmd.com/read/28319002/hba1c-in-relation-to-incident-diabetes-and-diabetes-related-complications-in-non-diabetic-adults-at-baseline
#2
Patricia Anne Metcalf, Cam Kyle, Tim Kenealy, Rod T Jackson
AIMS: We compared the utility of glycated hemoglobin (HbA1c) and oral glucose tolerance (oGTT) in non-diabetic patients for identifying incident diabetes; all-cause mortality; cardiovascular disease (CVD) mortality; CVD, coronary heart disease (CHD), and ischemic stroke events; and diabetes microvascular complications. METHODS: Data from a New Zealand community setting were prospectively linked to hospitalization, mortality, pharmaceutical and laboratory test results data...
February 21, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28315720/the-protective-effect-of-the-active-components-of-erpc-on-diabetic-peripheral-neuropathy-in-rats
#3
Gai-Mei Hao, Yong-Gang Liu, Yan Wu, Wei Xing, Shu-Zhen Guo, Yong Wang, Zheng-Lin Wang, Chun Li, Tian-Tian Lv, Hong-Liang Wang, Tian-Jiao Shi, Wei Wang, Jing Han
ETHNOPHARMACOLOGICAL RELEVANCE: Euonymus alatus, Radix trichosanthis, Panax notoginseng and Coptis chinensis are popular plants used in traditional Chinese medicine to treat diabetes. AIM OF THE STUDY: The aim of the study is to investigate the therapeutic effect of the active components of Euonymus alatus, Radix trichosanthis, Panax notoginseng and Coptis chinensis (cERPC) on diabetic peripheral neuropathy in the rats and explore the underlying mechanism involved...
March 15, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28301583/correction-cardiovascular-variability-analysis-and-baroreflex-estimation-in-patients-with-type-2-diabetes-in-absence-of-any-manifest-neuropathy
#4
Sílvia Cristina Garcia de Moura-Tonello, Alberto Porta, Andrea Marchi, Alessandra de Almeida Fagundes, Cristina de Oliveira Francisco, Patrícia Rehder-Santos, Juliana Cristina Milan-Mattos, Rodrigo Polaquini Simões, Mariana de Oliveira Gois, Aparecida Maria Catai
[This corrects the article DOI: 10.1371/journal.pone.0148903.].
2017: PloS One
https://www.readbyqxmd.com/read/28299330/erythropoietin-modification-enhances-the-protection-of-mesenchymal-stem-cells-on-diabetic-rat-derived-schwann-cells-implications-for-diabetic-neuropathy
#5
Shuyun Zhang, Baolin Shi
Diabetes-triggered apoptosis of Schwann cells (SC) contributes to the degradation of diabetic peripheral neuropathy (DNP). In recent years, mesenchymal stem cells (MSC) were applied to DPN repair and it was demonstrated that paracrine secretion played a key role in neuroprotection exerted by MSC. Erythropoietin (EPO) is a potent cytokine capable of reducing apoptosis of SC. However, the expression of EPO in MSC is limited. In this study, we hypothesized that overexpression of EPO in MSC (EPO-MSC) may significantly improve their neuroprotective potentials...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28293857/effect-of-cilostazol-in-treating-diabetes-associated-microvascular-complications
#6
REVIEW
Nicole J Asal, Karolina A Wojciak
PURPOSE: Cilostazol (Pletal), a phosphodiesterase-3 inhibitor, was approved in the United States in 1999 to reduce symptoms of intermittent claudication. Cyclic adenosine monophosphate levels increase from inhibition of phosphodiesterase resulting in anti-platelet, anti-inflammatory, and vasodilatory effects. Diabetes mellitus is a chronic disease that causes endothelial and platelet dysfunction leading to both microvascular and macrovascular complications. This mini-review highlights the emerging evidence suggesting benefits of using cilostazol in treating microvascular complications associated with diabetes mellitus...
March 14, 2017: Endocrine
https://www.readbyqxmd.com/read/28293643/neutrophils-infiltrate-the-spinal-cord-parenchyma-of-rats-with-experimental-diabetic-neuropathy
#7
Victoria L Newton, Jonathan D Guck, Mary A Cotter, Norman E Cameron, Natalie J Gardiner
Spinal glial cell activation and cytokine secretion have been implicated in the etiology of neuropathic pain in a number of experimental models, including diabetic neuropathy. In this study, streptozotocin- (STZ-) induced diabetic rats were either untreated or treated with gabapentin (50 mg/kg/day by gavage for 2 weeks, from 6 weeks after STZ). At 8 weeks after STZ, hypersensitivity was confirmed in the untreated diabetic rats as a reduced response threshold to touch, whilst mechanical thresholds in gabapentin-treated diabetic rats were no different from controls...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28290778/improved-neural-microcirculation-and-regeneration-after-peripheral-nerve-decompression-in-dpn-rats
#8
Wenxiang Zhong, Min Yang, Wenchuan Zhang, Massimiliano Visocchi, Xiangjun Chen, Chenlong Liao
OBJECTIVE: Recently, neural microcirculation and regeneration were regarded as critical factors in diabetic peripheral neuropathy (DPN) improvement. In the present study, we explored the cytological and molecular mechanisms how peripheral nerve decompression impaired nerve injury. METHODS: Forty-five male SD rats were established as the DPN model. HE staining was used to observe the morphology and distribution of microvessels. Transmission electron microscopy was applied to observe the morphology and distribution of Schwann cells...
March 14, 2017: Neurological Research
https://www.readbyqxmd.com/read/28289638/comparison-of-gait-speed-and-peripheral-nerve-function-between-chronic-kidney-disease-patients-with-and-without-diabetes
#9
Seung Hwan Jin, Young Sook Park, Yun Hee Park, Hyun Jung Chang, Sung Rok Kim
OBJECTIVE: To compare overall physical function, including gait speed and peripheral nerve function, between diabetic chronic kidney disease (CKD) patients and nondiabetic CKD patients and to investigate the association between gait speed and peripheral nerve function in CKD patients. METHODS: Sixty adult CKD patients (35 with and 25 without diabetes), who received maintenance hemodialysis (HD), were included in this study. Demographic data, past medical history, current medical condition and functional data-usual gait speed, vibration perception threshold for the index finger (VPT-F) and the great toe (VPT-T), activity of daily living (ADL) difficulty, and peripheral neuropathy (PN) along with the degree of its severity-were collected and compared between the two groups...
February 2017: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28286285/minocycline-reduces-mechanical-allodynia-and-depressive-like-behaviour-in-type-1-diabetes-mellitus-in-the-rat
#10
Diana Amorim, Sónia Puga, Rui Bragança, António Braga, Antti Pertovaara, Armando Almeida, Filipa Pinto-Ribeiro
A common and devastating complication of diabetes mellitus is painful diabetic neuropathy (PDN) that can be accompanied by emotional disorders such as depression. A few studies have suggested that minocycline that inhibits microglia may attenuate pain hypersensitivity in PDN. Moreover, a recent study reported that minocycline has an acute antidepressive-like effect in diabetic animals. Here we studied whether (i) prolonged minocycline treatment suppresses pain behaviour in PDN, (ii) the minocycline effect varies with submodality of pain, and (iii) the suppression of pain behaviour by prolonged minocycline treatment is associated with antidepressive-like effect...
March 7, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28285988/essential-parameters-and-risk-factors-of-the-patients-for-diabetes-care-and-treatment
#11
Abdulbari Bener, Fatma Ela Keskin, Eda M Kurtulus, Mustafa Guzel, Elif I Çekirdekçi, Pınar Kadıoğlu, Dildar Konukoğlu, Mustafa Öztürk
AIM: The aim was to explore the association between Type 2 Diabetes Mellitus [T2DM] treatment satisfactions of patients regarding their socio-economic, life-style, history medication and clinical outcome in a Turkish population SUBJECT AND METHODS: A cross-sectional study conducted from February 2016 to September 2016. Of the total 1500 diabetic patients approached, 1094 (72.9%) gave their consent. Data analysis included, sociodemographic, serum lipid profiles (LDL, HDL), calcium, uric acid, blood pressure and glycated hemoglobin (HbA1c) at baseline and after six months...
March 6, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28280746/electrochemical-skin-conductance-may-be-used-to-screen-for-diabetic-cardiac-autonomic-neuropathy-in-a-chinese-population-with-diabetes
#12
Tianyi He, Chuan Wang, Anju Zuo, Pan Liu, Ruxing Zhao, Wenjuan Li, Li Chen, Xinguo Hou
Aims. This study aimed to assess whether the electrochemical skin conductance (ESC) could be used to screen for diabetic cardiac autonomic neuropathy (DCAN) in a Chinese population with diabetes. Methods. We recruited 75 patients with type 2 diabetes mellitus (T2DM) and 45 controls without diabetes. DCAN was diagnosed by the cardiovascular autonomic reflex tests (CARTs) as gold standard. In all subjects ESCs of hands and feet were also detected by SUDOSCAN™ as a new screening method. The efficacy was assessed by receiver operating characteristic (ROC) curve analysis...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28277067/platelet-activation-by-adp-is-increased-in-selected-patients-with-anterior-ischemic-optic-neuropathy-or-retinal-vein-occlusion
#13
Claudia Kuhli-Hattenbach, Peter Hellstern, Thomas Kohnen, Lars-Olof Hattenbach
To investigate whether adenosine diphosphate (ADP)-induced platelet hyperaggregability is associated with nonarteritic anterior ischemic optic neuropathy (NAION) or retinal vein occlusion (RVO). We retrospectively reviewed thrombophilia screening data of patients with NAION or RVO without a history of arterial hypertension, diabetes mellitus, hyperlipidemia, obesity, and cigarette abuse. Patients with a positive family history for thromboembolism were not excluded. Platelet aggregation (area under the curve, AUC) after induction of 0...
February 16, 2017: Platelets
https://www.readbyqxmd.com/read/28272773/comparative-rna-seq-transcriptome-analyses-reveal-distinct-metabolic-pathways-in-diabetic-nerve-and-kidney-disease
#14
Lucy M Hinder, Meeyoung Park, Amy E Rumora, Junguk Hur, Felix Eichinger, Subramaniam Pennathur, Matthias Kretzler, Frank C Brosius, Eva L Feldman
Treating insulin resistance with pioglitazone normalizes renal function and improves small nerve fibre function and architecture; however, it does not affect large myelinated nerve fibre function in mouse models of type 2 diabetes (T2DM), indicating that pioglitazone affects the body in a tissue-specific manner. To identify distinct molecular pathways regulating diabetic peripheral neuropathy (DPN) and nephropathy (DN), as well those affected by pioglitazone, we assessed DPN and DN gene transcript expression in control and diabetic mice with or without pioglitazone treatment...
March 8, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28268785/establishment-of-a-measurement-method-for-in-shoe-pressure-and-shear-stress-in-specific-regions-for-diabetic-ulcer-prevention
#15
Ayumi Amemiya, Hiroshi Noguchi, Makoto Oe, Hiromi Sanada, Taketoshi Mori
Pressure and shear stress are the factors of diabetic foot ulcers and callus formation. However, in-shoe shear stress of callus measurement could not have been measured because of technical difficulties. The purpose of this study is to verify reliability and validity of the established measurement system for in-shoe pressure and shear stress. For reliability, coefficients of variation (CV) and intraclass correlation coefficients (ICC) were confirmed. For known-groups validity, callus and non-callus feet were compared...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268476/heart-rate-independent-qt-variability-component-can-detect-subclinical-cardiac-autonomic-neuropathy-in-diabetes
#16
Mohammad H Imam, Chandan K Karmakar, Ahsan H Khandoker, Herbert F Jelinek, M Palaniswami
Cardiac autonomic neuropathy (CAN) may lead to life threatening arrhythmia due to denervation of both the parasympathetic and sympathetic branches of autonomic nervous system innervating the heart. CAN is a frequently under diagnosed complication of diabetes, because a patient can have asymptomatic CAN for several years before it is clinically apparent. However, detection of CAN at the early or subclinical stage leads to more effective treatment outcomes. Cardiac autonomic reflex tests (CART) (i.e. Ewing test battery) are normally used for the detection and staging of CAN...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268190/the-short-version-of-the-activities-specific-balance-confidence-scale-for-older-adults-with-diabetes-convergent-discriminant-and-concurrent-validity-a-pilot-study
#17
Patricia Hewston, Nandini Deshpande
OBJECTIVES: The short version of the Activities-Specific Balance Confidence Scale (ABC-6) is advantageous in busy clinical or research settings because it can be administered in less time than the original 16-item Activities-Specific Balance Confidence Scale (ABC-16). This pilot study examined the convergent, discriminant and concurrent validity of the ABC-6 in older adults with diabetes mellitus with and without diagnosed diabetic peripheral neuropathy (DPN). METHODS: Thirty older adults (aged ≥65) were age- and sex-matched in 3 groups: 10 with diabetes (DM group), 10 with diagnosed DPN (DPN group) and 10 without diabetes (no-DM group)...
March 3, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28267271/do-we-underestimate-influences-of-diabetic-mononeuropathy-or-polyneuropathy-on-hand-functional-performance-and-life-quality
#18
Chien-Ju Yang, Hsiu-Yun Hsu, Chieh-Hsiang Lu, Yen-Li Chao, Haw-Yen Chiu, Li-Chieh Kuo
AIMS/INTRODUCTION: The purpose of this study is to identify whether there are differences in hand dexterity, hand functional performance and quality of life between diabetes hands with mononeuropathy and polyneuropathy to further present the importance regarding impacts of diabetic neuropathic deficits on patient's functional capacity. MATERIALS AND METHODS: The neurological deficits of 127 patients with type 2 diabetes were examined by electrophysiological tests for the median and ulnar nerves and were stratified into the diabetic mononeuropathy, diabetic polyneuropathy and non-diabetic neuropathy groups by sensory amplitude of these nerves...
March 7, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28267267/peripheral-neuropathy-in-prediabetes-and-the-metabolic-syndrome
#19
REVIEW
Amro M Stino, A Gordon Smith
Peripheral neuropathy is a major cause of disability worldwide. Diabetes is the most common cause of neuropathy, accounting for 50% of cases. Over half of people with diabetes develop neuropathy, and diabetic neuropathy (DPN) is a major cause of reduced quality of life due to pain, sensory loss, gait instability, fall related injury, and foot ulceration and amputation. Most patients with nondiabetic neuropathy have cryptogenic sensory peripheral neuropathy (CSPN). A growing body of literature links prediabetes, obesity and metabolic syndrome (MetS) to risk of both DPN and CSPN (CSPN-MetS)...
March 7, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28267059/diagnostic-accuracy-of-laser-evoked-potentials-in-diabetic-neuropathy
#20
G Di Stefano, S La Cesa, C Leone, A Pepe, E Galosi, M Fiorelli, M Valeriani, M Lacerenza, M Pergolini, A Biasiotta, G Cruccu, A Truini
Although the most widely agreed neurophysiological tool for investigating small fibre damage is laser evoked potential (LEP) recording, no study has documented its diagnostic accuracy. In this clinical, neurophysiological and skin biopsy study we collected age-corrected LEP normative ranges, verified the association of LEPs with pinprick sensory disturbances in the typical diabetic mixed-fibre polyneuropathy and assessed the sensitivity and specificity of LEPs in diabetic small-fibre neuropathy.From 288 LEP recordings from the face, hand and foot in 73 healthy subjects we collected age-corrected normative ranges for LEPs...
March 4, 2017: Pain
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