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https://www.readbyqxmd.com/read/28542357/the-nrf2-transcription-factor-plays-a-dual-role-in-colorectal-cancer-a-systematic-review
#1
C Gonzalez-Donquiles, J Alonso-Molero, T Fernandez-Villa, L Vilorio-Marqués, A J Molina, V Martín
BACKGROUND: Colorectal cancer is one of the most common cancers worldwide, and is influenced by the interplay of various factors, including a very strong genetic component. For instance, incorrect mitochondrial biogenesis is correlated with increased risk of developing colorectal cancer. Thus, it is important to understand the consequences of changes in both the expression and the correct function of the transcription factors that regulate mitochondrial biogenesis, namely NRF2. OBJECTIVES: The main objective of this paper is to characterise the relationship between NRF2 and colorectal cancer by compiling data from an exhaustive literature search...
2017: PloS One
https://www.readbyqxmd.com/read/28538385/surgical-outcomes-of-different-approaches-to-esophageal-replacement-in-long-gap-esophageal-atresia-a-systematic-review
#2
Jia Liu, Yifan Yang, Chao Zheng, Rui Dong, Shan Zheng
BACKGROUND: Esophageal replacement (ER) surgery has been widely used in long-gap esophageal atresia (LGEA) over the past few decades. The most commonly used surgical approaches in many pediatric surgical centers include colon interposition (CI), gastric pull-up (GPU), jejunal interposition (JI), and gastric tube reconstruction (GTR). However, there is no systematic evidence on which is the optimal conduit for the native esophagus. The aim of this systematic review was to evaluate the short- and long-term outcomes among these 4 replacement approaches in LGEA cases based on current evidence...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28531835/postpartum-acute-colonic-pseudo-obstruction-ogilvie-s-syndrome-a-systematic-review-of-case-reports-and-case-series
#3
REVIEW
Pradeep Jayaram, Manoj Mohan, Stephen Lindow, Justin Konje
INTRODUCTION: Ogilvie's Syndrome or Acute Colonic Pseudo-Obstruction (ACPO) is a rare condition characterized by massive dilatation of the colon in the absence of mechanical obstruction. About 10% of all reported cases are related to Obstetric and Gynaecological procedures, Caesarean section being the commonest associated factor. Acute intestinal dilatation, if not treated, may lead to perforation and faecal peritonitis with consequent high morbidity and mortality. MATERIALS AND METHODS: An electronic literature searches were performed in PubMed, EMBASE, Google scholar and hand searches for relevant references were included without any language restriction...
May 2, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28524627/weight-loss-interventions-and-gut-microbiota-changes-in-overweight-and-obese-patients-a-systematic-review
#4
REVIEW
F B Seganfredo, C A Blume, M Moehlecke, A Giongo, D S Casagrande, J V N Spolidoro, A V Padoin, B D Schaan, C C Mottin
Imbalances in the gut microbiota, the bacteria that inhabit the intestines, are central to the pathogenesis of obesity. This systematic review assesses the association between the gut microbiota and weight loss in overweight/obese adults and its potential manipulation as a target for treating obesity. This review identified 43 studies using the keywords 'overweight' or 'obesity' and 'microbiota' and related terms; among these studies, 17 used dietary interventions, 11 used bariatric surgery and 15 used microbiota manipulation...
May 19, 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28522943/accuracy-of-computed-tomographic-features-in-differentiating-intestinal-tuberculosis-from-crohn-s-disease-a-systematic-review-with-meta-analysis
#5
REVIEW
Saurabh Kedia, Raju Sharma, Vishnubhatla Sreenivas, Kumble Seetharama Madhusudhan, Vishal Sharma, Sawan Bopanna, Venigalla Pratap Mouli, Rajan Dhingra, Dawesh Prakash Yadav, Govind Makharia, Vineet Ahuja
Abdominal computed tomography (CT) can noninvasively image the entire gastrointestinal tract and assess extraintestinal features that are important in differentiating Crohn's disease (CD) and intestinal tuberculosis (ITB). The present meta-analysis pooled the results of all studies on the role of CT abdomen in differentiating between CD and ITB. We searched PubMed and Embase for all publications in English that analyzed the features differentiating between CD and ITB on abdominal CT. The features included comb sign, necrotic lymph nodes, asymmetric bowel wall thickening, skip lesions, fibrofatty proliferation, mural stratification, ileocaecal area, long segment, and left colonic involvements...
April 2017: Intestinal Research
https://www.readbyqxmd.com/read/28521318/breastfeeding-childhood-asthma-and-allergic-disease
#6
Wendy H Oddy
The worldwide prevalence of childhood asthma has been increasing considerably, and the protection afforded by breastfeeding in its development has been the subject of controversy for more than 80 years. Previous systematic reviews have generally found a protective effect of breastfeeding on allergic outcomes, although many studies have methodological limitations. Although breastfeeding is protective against lower respiratory tract infection during infancy, such protection has not been demonstrated for asthma in all studies...
2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28514886/physiological-effects-of-prebiotics-and-its-role-in-prevention-of-necrotizing-enterocolitis-in-preterm-neonates
#7
Bhawan Deep Garg, Haribalakrishna Balasubramanian, Nandkishor S Kabra
Necrotizing enterocolitis (NEC) is one of the most serious gastrointestinal emergencies in very low birth weight (VLBW) preterm neonates, affecting 7% to 14% of these neonates. Due to seriousness of disease, prevention of NEC is the most important goal. Current evidence from systematic review and meta-analysis revealed probiotics are the most promising intervention in reduction of the incidence of NEC in VLBW neonates. As per the evidence, prebiotics modulate the composition of human intestine microflora to the benefit of the host by suppression of colonization of harmful microorganism and/or the stimulation of bifidobacterial growth, decreased stool viscosity, reduced gastrointestinal transit time and better feed tolerance...
May 17, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28486497/towards-decision-making-using-individualized-risk-estimates-for-personalized-medicine-a-systematic-review-of-genomic-classifiers-of-solid-tumors
#8
Daniel M Trifiletti, Vanessa N Sturz, Timothy N Showalter, Jennifer M Lobo
Recent advances in the understanding of the genetic underpinnings of cancer offer the promise to customize cancer treatments to the individual through the use of genomic classifiers (GCs). At present, routine clinical utilization of GCs is uncommon and their current scope and status, in a broad sense, are unknown. As part of a registered review (PROSPERO 2014:CRD42014013371), we systematically reviewed the literature evaluating the utility of commercially available GCs by searching Ovid Medline (PubMed), EMBASE, the Cochrane Database of Systematic Reviews, and CINAHL on September 2, 2014...
2017: PloS One
https://www.readbyqxmd.com/read/28482504/bioactive-glass-for-dentin-remineralization-a-systematic-review
#9
REVIEW
Delihta Fernando, Nina Attik, Nelly Pradelle-Plasse, Phil Jackson, Brigitte Grosgogeat, Pierre Colon
BACKGROUND AND OBJECTIVES: Strategies to achieve dentin remineralization is at present an important target of restorative dentistry. Remineralization of dentin by a bioactive material is complete only when the tissue regains its functionality. This is achieved when there is adequate apatite formation which most importantly translates into improved mechanical properties of dentin as a result of intrafibrillar mineralization. Bioactive glass (BAG) is a well-known implant material for bone regeneration and is proven to have excellent ability of apatite formation...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28480243/colonization-with-vancomycin-resistant-enterococci-and-risk-for-bloodstream-infection-among-patients-with-malignancy-a-systematic-review-and-meta-analysis
#10
Michail Alevizakos, Apostolos Gaitanidis, Dimitrios Nasioudis, Katerina Tori, Myrto Eleni Flokas, Eleftherios Mylonakis
BACKGROUND: Vancomycin-resistant enterococci (VRE) cause severe infections among patients with malignancy, and these infections are usually preceded by gastrointestinal colonization. METHODS: We searched the PubMed and EMBASE databases (up to May 26, 2016) to identify studies that reported data on VRE gastrointestinal colonization among patients with solid or hematologic malignancy. RESULTS: Thirty-four studies, reporting data on 8391 patients with malignancy, were included in our analysis...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28479472/implications-of-clostridium-septicum-in-vascular-surgery-a-case-report-and-outcomes-literature-review
#11
Yewande Alimi, Michael Sosin, Tracy M Borsinger, John R Garrett, J R Salameh, C Francisco Espinel
Clostridium septicum is a rare organism, accounting for approximately 1.3% of clostridial infections and is associated with synchronous colonic malignancy. This case report describes a patient successfully treated for a mycotic aortic aneurysm secondary to C. septicum bacteremia. Subsequent evaluation confirmed a colonic malignancy, prompting early intervention. A systematic literature review revealing a rate of gastrointestinal malignancy in this patient population is 71%, hematologic malignancy is 3.9%, with the remaining cohort of patients having an unknown source...
May 4, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28475791/prevention-and-control-of-multidrug-resistant-gram-negative-bacteria-in-adult-intensive-care-units-a-systematic-review-and-network-meta-analysis
#12
Nattawat Teerawattanapong, Kirati Kengkla, Piyameth Dilokthornsakul, Surasak Saokaew, Anucha Apisarnthanarak, Nathorn Chaiyakunapruk
Background: This study evaluated the relative efficacy of strategies for the prevention of multidrug-resistant gram-negative bacteria (MDR-GNB) in adult intensive care units (ICUs). Methods: A systematic review and network meta-analysis was performed; searches of the Cochrane Library, PubMed, Embase, and CINAHL (Cumulative Index to Nursing and Allied Health Literature) included all randomized controlled trials and observational studies conducted in adult patients hospitalized in ICUs and evaluating standard care (STD), antimicrobial stewardship program (ASP), environmental cleaning (ENV), decolonization methods (DCL), or source control (SCT), simultaneously...
May 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28475779/comparative-efficacy-of-antimicrobial-central-venous-catheters-in-reducing-catheter-related-bloodstream-infections-in-adults-abridged-cochrane-systematic-review-and-network-meta-analysis
#13
Huey Yi Chong, Nai Ming Lai, Anucha Apisarnthanarak, Nathorn Chaiyakunapruk
Background: The efficacy of antimicrobial central venous catheters (CVCs) remains questionable. In this network meta-analysis, we aimed to assess the comparative efficacy of antimicrobial CVC impregnations in reducing catheter-related infections in adults. Methods: We searched 4 electronic databases (Medline, the Cochrane Central Register of Controlled Trials, Embase, CINAHL) and internet sources for randomized controlled trials, ongoing clinical trials, and unpublished studies up to August 2016...
May 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28471838/risk-of-colorectal-cancer-and-associated-mortality-in-hiv-a-systematic-review-and-meta-analysis
#14
Tyler J O'Neill, Joseph Djiometio Nguemo, Anne-Marie Tynan, Ann N Burchell, Tony Antoniou
BACKGROUND: As people with HIV live longer, the numbers of colorectal cancer cases are expected to increase. We sought to compare colorectal cancer incidence and cause-specific mortality among people living with and without HIV. DESIGN: Systematic review and meta-analysis. METHODS: We searched five electronic databases to 28 June 2016 for primary studies reporting standardized incidence ratios (SIR), standardized mortality ratios (SMR)/hazard ratios or data sufficient for estimating these summary measures...
May 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28470365/objective-assessment-of-minimally-invasive-total-mesorectal-excision-performance-a-systematic-review
#15
REVIEW
N J Curtis, J Davids, J D Foster, N K Francis
INTRODUCTION: Laparoscopy is widely used in colorectal practice, but recent trial results have questioned its use in rectal cancer resections. Patient outcomes are directly linked to the quality of total mesorectal excision (TME) specimen. Objective assessment of intraoperative performance could help ensure competence and delivery of optimal outcomes. Objective tools may also contribute to TME intervention trials, but their nature, structure and utilisation is unknown. AIM: To systemically review the available literature to report on the available tools for the objective assessment of minimally invasive TME operative performance and their use within multicentre laparoscopic TME randomised controlled trials...
April 2017: Techniques in Coloproctology
https://www.readbyqxmd.com/read/28458834/stoma-prolapse-handmade-repair-under-local-anesthesia-with-variation-of-altemeier-method-in-severe-patients-a-case-report-and-review-of-the-literature
#16
Vasileios Papadopoulos, Petros Bangeas, Kassandra Xanthopoulou, Daniel Paramythiotis, Antonios Michalopoulos
Stoma prolapse represents one of the most common late complications, occurring in 1-16%. Final rate depends on systematic follow up of the patient and the primary technique. A 49-year-old male patient presented in the Emergency Department, complaining about stoma prolapse, pain and stoma care difficulties. On admission, his colostomy protruded ~20 cm from the skin. The symptoms were local pain and psychological stress. The prolapse was repaired successfully with a simple revision procedure under local anesthesia, by resecting the prolapsed part of the bowel and reconstruction of stoma...
February 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28456321/prevalence-of-multidrug-resistant-gram-negative-bacteria-among-nursing-home-residents-a-systematic-review-and-meta-analysis
#17
Sainfer Aliyu, Arlene Smaldone, Elaine Larson
BACKGROUND: Multidrug-resistant gram-negative bacteria (MDR-GNB) are associated with an increasing proportion of infections among nursing home (NH) residents. The objective of this systematic review and meta-analysis was to critically review evidence of the prevalence of MDR-GNB among NH residents. METHODS: Following Meta-Analysis of Observational Studies in Epidemiology guidelines, a systematic review of literature for the years 2005-2016 using multiple databases was conducted...
May 1, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28449361/systematic-review-with-meta-analysis-proximal-disease-extension-in-limited-ulcerative-colitis
#18
REVIEW
G Roda, N Narula, R Pinotti, A Skamnelos, K H Katsanos, R Ungaro, J Burisch, J Torres, J-F Colombel
BACKGROUND: Disease extent in ulcerative colitis is one of the major factors determining prognosis over the long-term. Disease extent is dynamic and a proportion of patients presenting with limited disease progress to more extensive forms of disease over time. AIM: To perform a systematic review and meta-analysis of epidemiological studies reporting on extension of ulcerative colitis to determine frequency of disease extension in patients with limited ulcerative colitis at diagnosis...
April 27, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28449338/metformin-use-and-the-risk-of-colorectal-adenoma-a-systematic-review-and-meta-analysis
#19
Yoon Suk Jung, Chan Hyuk Park, Chang Soo Eun, Dong Il Park, Dong Soo Han
BACKGROUND AND AIM: Although it is known that metformin can reduce risk of colorectal cancer, it is unclear whether it protects against colorectal adenoma. METHODS: This study conducted a systematic literature search on MEDLINE, EMBASE, and the Cochrane Library using the primary keywords "colorectal," "colon," "rectal," "rectum," "adenoma," "polyp," "neoplasia," "neoplasm," "metformin," and "diabetes." Studies were included if they evaluated the association between metformin use and colorectal adenoma and reported odds ratios (ORs) or provided data from which these could be estimated...
May 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28439845/a-systematic-review-of-the-clinical-presentation-diagnosis-and-treatment-of-small-bowel-obstruction
#20
REVIEW
Srinivas R Rami Reddy, Mitchell S Cappell
PURPOSE OF REVIEW: This study aimed to systematically review small bowel obstruction (SBO), focusing on recent changes in diagnosis/therapy. RECENT FINDINGS: SBO incidence is about 350,000/annum in the USA. Etiologies include adhesions (65%), hernias (10%), neoplasms (5%), Crohn's disease (5%), and other (15%). Bowel dilatation occurs proximal to obstruction primarily from swallowed air and secondarily from intraluminal fluid accumulation. Dilatation increases mural tension, decreases mucosal perfusion, causes bacterial proliferation, and decreases mural tensile strength that increases bowel perforation risks...
June 2017: Current Gastroenterology Reports
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