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Markus Moeller

Raphael Martin Jay, Jesper Norell, Sebastian Eckert, Markus Hantschmann, Martin Beye, Brian Kennedy, Wilson Quevedo, William F Schlotter, Georgi L Dakovski, Michael P Minitti, Matthias C Hoffmann, Ankush Mitra, Stefan P Moeller, Dennis Nordlund, Wenkai Zhang, H Winnie Liang, Kristjan Kunnus, Katharina Kubicek, Simone Agnes Techert, Marcus Lundberg, Philippe Wernet, Kelly J Gaffney, Michael Odelius, Alexander Foehlisch
Soft X-ray spectroscopies are ideal probes of the local valence electronic structure of photocatalytically active metal sites. Here, we apply the selectivity of time-resolved resonant inelastic X-ray scattering at the iron L-edge to the transient charge distribution of an optically excited charge-transfer state in aqueous ferricyanide. Through comparison to steady-state spectra and quantum chemical calculations, the coupled effects of valence-shell closing and ligand-hole creation are experimentally and theoretically disentangled and described in terms of orbital occupancy, metal-ligand covalency and ligand field splitting, thereby extending established steady-state concepts to the excited-state domain...
June 11, 2018: Journal of Physical Chemistry Letters
Jennifer Eymael, Shagun Sharma, Markus A Loeven, Jack F Wetzels, Fieke Mooren, Sandrine Florquin, Jeroen K Deegens, Brigith K Willemsen, Vikram Sharma, Toin H van Kuppevelt, Marinka A Bakker, Tammo Ostendorf, Marcus J Moeller, Henry B Dijkman, Bart Smeets, Johan van der Vlag
A key feature of glomerular diseases such as crescentic glomerulonephritis and focal segmental glomerulosclerosis is the activation, migration and proliferation of parietal epithelial cells. CD44-positive activated parietal epithelial cells have been identified in proliferative cellular lesions in glomerular disease. However, it remains unknown whether CD44-positive parietal epithelial cells contribute to the pathogenesis of scarring glomerular diseases. Here, we evaluated this in experimental crescentic glomerulonephritis and the transgenic anti-Thy1...
March 2018: Kidney International
Markus Kubin, Jan Kern, Sheraz Gul, Thomas Kroll, Ruchira Chatterjee, Heike Löchel, Franklin D Fuller, Raymond G Sierra, Wilson Quevedo, Christian Weniger, Jens Rehanek, Anatoly Firsov, Hartawan Laksmono, Clemens Weninger, Roberto Alonso-Mori, Dennis L Nordlund, Benedikt Lassalle-Kaiser, James M Glownia, Jacek Krzywinski, Stefan Moeller, Joshua J Turner, Michael P Minitti, Georgi L Dakovski, Sergey Koroidov, Anurag Kawde, Jacob S Kanady, Emily Y Tsui, Sandy Suseno, Zhiji Han, Ethan Hill, Taketo Taguchi, Andrew S Borovik, Theodor Agapie, Johannes Messinger, Alexei Erko, Alexander Föhlisch, Uwe Bergmann, Rolf Mitzner, Vittal K Yachandra, Junko Yano, Philippe Wernet
X-ray absorption spectroscopy at the L-edge of 3d transition metals provides unique information on the local metal charge and spin states by directly probing 3d-derived molecular orbitals through 2p-3d transitions. However, this soft x-ray technique has been rarely used at synchrotron facilities for mechanistic studies of metalloenzymes due to the difficulties of x-ray-induced sample damage and strong background signals from light elements that can dominate the low metal signal. Here, we combine femtosecond soft x-ray pulses from a free-electron laser with a novel x-ray fluorescence-yield spectrometer to overcome these difficulties...
September 2017: Structural Dynamics (Melville, N.Y.)
Christine Neuhaus, Tobias Eisenberger, Christian Decker, Sandra Nagl, Cornelia Blank, Markus Pfister, Ingo Kennerknecht, Cornelie Müller-Hofstede, Peter Charbel Issa, Raoul Heller, Bodo Beck, Klaus Rüther, Diana Mitter, Klaus Rohrschneider, Ute Steinhauer, Heike M Korbmacher, Dagmar Huhle, Solaf M Elsayed, Hesham M Taha, Shahid M Baig, Heidi Stöhr, Markus Preising, Susanne Markus, Fabian Moeller, Birgit Lorenz, Kerstin Nagel-Wolfrum, Arif O Khan, Hanno J Bolz
BACKGROUND: Combined retinal degeneration and sensorineural hearing impairment is mostly due to autosomal recessive Usher syndrome (USH1: congenital deafness, early retinitis pigmentosa (RP); USH2: progressive hearing impairment, RP). METHODS: Sanger sequencing and NGS of 112 genes (Usher syndrome, nonsyndromic deafness, overlapping conditions), MLPA, and array-CGH were conducted in 138 patients clinically diagnosed with Usher syndrome. RESULTS: A molecular diagnosis was achieved in 97% of both USH1 and USH2 patients, with biallelic mutations in 97% (USH1) and 90% (USH2), respectively...
September 2017: Molecular Genetics & Genomic Medicine
Mark Moeller, Christiane Pink, Nicole Endlich, Karlhans Endlich, Hans-Jörgen Grabe, Henry Völzke, Marcus Dörr, Matthias Nauck, Markus M Lerch, Rüdiger Köhling, Birte Holtfreter, Thomas Kocher, Georg Fuellen
Lifespan is a complex trait, and longitudinal data for humans are naturally scarce. We report the results of Cox regression and Pearson correlation analyses using data of the Study of Health in Pomerania (SHIP), with mortality data of 1518 participants (113 of which died), over a time span of more than 10 years. We found that in the Cox regression model based on the Bayesian information criterion, apart from chronological age of the participant, six baseline variables were considerably associated with higher mortality rates: smoking, mean attachment loss (i...
2017: PloS One
Sebastian Eckert, Jesper Norell, Piter S Miedema, Martin Beye, Mattis Fondell, Wilson Quevedo, Brian Kennedy, Markus Hantschmann, Annette Pietzsch, Benjamin E Van Kuiken, Matthew Ross, Michael P Minitti, Stefan P Moeller, William F Schlotter, Munira Khalil, Michael Odelius, Alexander Föhlisch
The femtosecond excited-state dynamics following resonant photoexcitation enable the selective deformation of N-H and N-C chemical bonds in 2-thiopyridone in aqueous solution with optical or X-ray pulses. In combination with multiconfigurational quantum-chemical calculations, the orbital-specific electronic structure and its ultrafast dynamics accessed with resonant inelastic X-ray scattering at the N 1s level using synchrotron radiation and the soft X-ray free-electron laser LCLS provide direct evidence for this controlled photoinduced molecular deformation and its ultrashort timescale...
May 22, 2017: Angewandte Chemie
Markus Friedemann, Liv Kalbitzer, Sandra Franz, Stephanie Moeller, Matthias Schnabelrauch, Jan-Christoph Simon, Tilo Pompe, Katja Franke
Dynamic alterations of composition and mechanics of the extracellular matrix are suggested to modulate cellular behavior including plasticity of macrophages (MPhs) during wound healing. In this study, engineered 3D fibrillar matrices based on naturally occurring biopolymers (collagen I, glycosaminoglycans (GAGs)) are used to mimic matrix stiffening as well as modification by sulfated and nonsulfated GAGs at different stages of wound healing. Human MPhs are found to sensitively respond to these microenvironmental cues in terms of polarization toward proinflammatory or wound healing phenotypes over 6 days in vitro...
April 2017: Advanced Healthcare Materials
Thomas Kroll, Jan Kern, Markus Kubin, Daniel Ratner, Sheraz Gul, Franklin D Fuller, Heike Löchel, Jacek Krzywinski, Alberto Lutman, Yuantao Ding, Georgi L Dakovski, Stefan Moeller, Joshua J Turner, Roberto Alonso-Mori, Dennis L Nordlund, Jens Rehanek, Christian Weniger, Alexander Firsov, Maria Brzhezinskaya, Ruchira Chatterjee, Benedikt Lassalle-Kaiser, Raymond G Sierra, Hartawan Laksmono, Ethan Hill, Andrew Borovik, Alexei Erko, Alexander Föhlisch, Rolf Mitzner, Vittal K Yachandra, Junko Yano, Philippe Wernet, Uwe Bergmann
X-ray free electron lasers (XFELs) enable unprecedented new ways to study the electronic structure and dynamics of transition metal systems. L-edge absorption spectroscopy is a powerful technique for such studies and the feasibility of this method at XFELs for solutions and solids has been demonstrated. However, the required x-ray bandwidth is an order of magnitude narrower than that of self-amplified spontaneous emission (SASE), and additional monochromatization is needed. Here we compare L-edge x-ray absorption spectroscopy (XAS) of a prototypical transition metal system based on monochromatizing the SASE radiation of the linac coherent light source (LCLS) with a new technique based on self-seeding of LCLS...
October 3, 2016: Optics Express
Markus J Kettel, Elisabeth Heine, Karola Schaefer, Martin Moeller
Antimicrobial nanogels, aggregates, and films are prepared by complexation of the antiseptic and bacteriostatic agent chlorhexidine (CHX) for medical and dental applications. A series of α-, β-, and γ-cyclodextrin methacrylate (CD-MA) containing hydrophobic poly(methyl methacrylate) (PMMA) based nanogels are loaded quantitatively with CHX in aqueous dispersion. The results show that CHX is enhancedly complexed by the use of CD-MA domains in the particles structure. β-CD-MA nanogels present the highest uptake of CHX...
February 2017: Macromolecular Bioscience
Martin Beye, Henrik Öberg, Hongliang Xin, Georgi L Dakovski, Martina Dell'Angela, Alexander Föhlisch, Jörgen Gladh, Markus Hantschmann, Florian Hieke, Sarp Kaya, Danilo Kühn, Jerry LaRue, Giuseppe Mercurio, Michael P Minitti, Ankush Mitra, Stefan P Moeller, May Ling Ng, Anders Nilsson, Dennis Nordlund, Jens Nørskov, Henrik Öström, Hirohito Ogasawara, Mats Persson, William F Schlotter, Jonas A Sellberg, Martin Wolf, Frank Abild-Pedersen, Lars G M Pettersson, Wilfried Wurth
The concept of bonding and antibonding orbitals is fundamental in chemistry. The population of those orbitals and the energetic difference between the two reflect the strength of the bonding interaction. Weakening the bond is expected to reduce this energetic splitting, but the transient character of bond-activation has so far prohibited direct experimental access. Here we apply time-resolved soft X-ray spectroscopy at a free-electron laser to directly observe the decreased bonding-antibonding splitting following bond-activation using an ultrashort optical laser pulse...
September 15, 2016: Journal of Physical Chemistry Letters
Timothy R Rebbeck, Nandita Mitra, Fei Wan, Olga M Sinilnikova, Sue Healey, Lesley McGuffog, Sylvie Mazoyer, Georgia Chenevix-Trench, Douglas F Easton, Antonis C Antoniou, Katherine L Nathanson, Yael Laitman, Anya Kushnir, Shani Paluch-Shimon, Raanan Berger, Jamal Zidan, Eitan Friedman, Hans Ehrencrona, Marie Stenmark-Askmalm, Zakaria Einbeigi, Niklas Loman, Katja Harbst, Johanna Rantala, Beatrice Melin, Dezheng Huo, Olufunmilayo I Olopade, Joyce Seldon, Patricia A Ganz, Robert L Nussbaum, Salina B Chan, Kunle Odunsi, Simon A Gayther, Susan M Domchek, Banu K Arun, Karen H Lu, Gillian Mitchell, Beth Y Karlan, Christine Walsh, Jenny Lester, Andrew K Godwin, Harsh Pathak, Eric Ross, Mary B Daly, Alice S Whittemore, Esther M John, Alexander Miron, Mary Beth Terry, Wendy K Chung, David E Goldgar, Saundra S Buys, Ramunas Janavicius, Laima Tihomirova, Nadine Tung, Cecilia M Dorfling, Elizabeth J van Rensburg, Linda Steele, Susan L Neuhausen, Yuan Chun Ding, Bent Ejlertsen, Anne-Marie Gerdes, Thomas v O Hansen, Teresa Ramón y Cajal, Ana Osorio, Javier Benitez, Javier Godino, Maria-Isabel Tejada, Mercedes Duran, Jeffrey N Weitzel, Kristie A Bobolis, Sharon R Sand, Annette Fontaine, Antonella Savarese, Barbara Pasini, Bernard Peissel, Bernardo Bonanni, Daniela Zaffaroni, Francesca Vignolo-Lutati, Giulietta Scuvera, Giuseppe Giannini, Loris Bernard, Maurizio Genuardi, Paolo Radice, Riccardo Dolcetti, Siranoush Manoukian, Valeria Pensotti, Viviana Gismondi, Drakoulis Yannoukakos, Florentia Fostira, Judy Garber, Diana Torres, Muhammad Usman Rashid, Ute Hamann, Susan Peock, Debra Frost, Radka Platte, D Gareth Evans, Rosalind Eeles, Rosemarie Davidson, Diana Eccles, Trevor Cole, Jackie Cook, Carole Brewer, Shirley Hodgson, Patrick J Morrison, Lisa Walker, Mary E Porteous, M John Kennedy, Louise Izatt, Julian Adlard, Alan Donaldson, Steve Ellis, Priyanka Sharma, Rita Katharina Schmutzler, Barbara Wappenschmidt, Alexandra Becker, Kerstin Rhiem, Eric Hahnen, Christoph Engel, Alfons Meindl, Stefanie Engert, Nina Ditsch, Norbert Arnold, Hans Jörg Plendl, Christoph Mundhenke, Dieter Niederacher, Markus Fleisch, Christian Sutter, C R Bartram, Nicola Dikow, Shan Wang-Gohrke, Dorothea Gadzicki, Doris Steinemann, Karin Kast, Marit Beer, Raymonda Varon-Mateeva, Andrea Gehrig, Bernhard H Weber, Dominique Stoppa-Lyonnet, Olga M Sinilnikova, Sylvie Mazoyer, Claude Houdayer, Muriel Belotti, Marion Gauthier-Villars, Francesca Damiola, Nadia Boutry-Kryza, Christine Lasset, Hagay Sobol, Jean-Philippe Peyrat, Danièle Muller, Jean-Pierre Fricker, Marie-Agnès Collonge-Rame, Isabelle Mortemousque, Catherine Nogues, Etienne Rouleau, Claudine Isaacs, Anne De Paepe, Bruce Poppe, Kathleen Claes, Kim De Leeneer, Marion Piedmonte, Gustavo Rodriguez, Katie Wakely, John Boggess, Stephanie V Blank, Jack Basil, Masoud Azodi, Kelly-Anne Phillips, Trinidad Caldes, Miguel de la Hoya, Atocha Romero, Heli Nevanlinna, Kristiina Aittomäki, Annemarie H van der Hout, Frans B L Hogervorst, Senno Verhoef, J Margriet Collée, Caroline Seynaeve, Jan C Oosterwijk, Johannes J P Gille, Juul T Wijnen, Encarna B Gómez Garcia, Carolien M Kets, Margreet G E M Ausems, Cora M Aalfs, Peter Devilee, Arjen R Mensenkamp, Ava Kwong, Edith Olah, Janos Papp, Orland Diez, Conxi Lazaro, Esther Darder, Ignacio Blanco, Mónica Salinas, Anna Jakubowska, Jan Lubinski, Jacek Gronwald, Katarzyna Jaworska-Bieniek, Katarzyna Durda, Grzegorz Sukiennicki, Tomasz Huzarski, Tomasz Byrski, Cezary Cybulski, Aleksandra Toloczko-Grabarek, Elżbieta Złowocka-Perłowska, Janusz Menkiszak, Adalgeir Arason, Rosa B Barkardottir, Jacques Simard, Rachel Laframboise, Marco Montagna, Simona Agata, Elisa Alducci, Ana Peixoto, Manuel R Teixeira, Amanda B Spurdle, Min Hyuk Lee, Sue K Park, Sung-Won Kim, Tara M Friebel, Fergus J Couch, Noralane M Lindor, Vernon S Pankratz, Lucia Guidugli, Xianshu Wang, Marc Tischkowitz, Lenka Foretova, Joseph Vijai, Kenneth Offit, Mark Robson, Rohini Rau-Murthy, Noah Kauff, Anneliese Fink-Retter, Christian F Singer, Christine Rappaport, Daphne Gschwantler-Kaulich, Georg Pfeiler, Muy-Kheng Tea, Andreas Berger, Mark H Greene, Phuong L Mai, Evgeny N Imyanitov, Amanda Ewart Toland, Leigha Senter, Anders Bojesen, Inge Sokilde Pedersen, Anne-Bine Skytte, Lone Sunde, Mads Thomassen, Sanne Traasdahl Moeller, Torben A Kruse, Uffe Birk Jensen, Maria Adelaide Caligo, Paolo Aretini, Soo-Hwang Teo, Christina G Selkirk, Peter J Hulick, Irene Andrulis
IMPORTANCE: Limited information about the relationship between specific mutations in BRCA1 or BRCA2 (BRCA1/2) and cancer risk exists. OBJECTIVE: To identify mutation-specific cancer risks for carriers of BRCA1/2. DESIGN, SETTING, AND PARTICIPANTS: Observational study of women who were ascertained between 1937 and 2011 (median, 1999) and found to carry disease-associated BRCA1 or BRCA2 mutations. The international sample comprised 19,581 carriers of BRCA1 mutations and 11,900 carriers of BRCA2 mutations from 55 centers in 33 countries on 6 continents...
April 7, 2015: JAMA: the Journal of the American Medical Association
Mark Moeller, Misa Hirose, Sarah Mueller, Catrin Roolf, Simone Baltrusch, Saleh Ibrahim, Christian Junghanss, Olaf Wolkenhauer, Robert Jaster, Rüdiger Köhling, Manfred Kunz, Markus Tiedge, Paul N Schofield, Georg Fuellen
Traditionally, biomarkers of aging are classified as either pro-longevity or antilongevity. Using longitudinal data sets from the large-scale inbred mouse strain study at the Jackson Laboratory Nathan Shock Center, we describe a protocol to identify two kinds of biomarkers: those with prognostic implication for lifespan and those with longitudinal evidence. Our protocol also identifies biomarkers for which, at first sight, there is conflicting evidence. Conflict resolution is possible by postulating a role switch...
August 2014: Aging Cell
Stefan Porubsky, Christoph Kuppe, Tanja Maier, Horst-Walter Birk, Markus Wörnle, Marcus J Moeller, Jürgen Floege, Hermann-Josef Gröne
Kidney biopsies often show accumulation of lipids or lipidlike material. Evidence has been provided that lipids can directly initiate and contribute to the progression of glomerular and tubulointerstitial lesions. In this study we describe a renal lipidosis occurring in patients with a positive history of narcotic abuse who were enrolled in a methadone substitution program. All 3 patients presented with proteinuria (2.5-20 g/d) and impaired renal function. Renal biopsy revealed a pronounced extracellular and intracellular deposition of lipidlike material in the glomerular, interstitial, and tubular compartments...
May 2014: Archives of Pathology & Laboratory Medicine
Homa Ghalei, Holger von Moeller, Detlef Eppers, Daniel Sohmen, Daniel N Wilson, Bernhard Loll, Markus C Wahl
Instead of a classical single-stranded deoxyribonuleic acid (DNA)-binding protein (SSB), some hyperthermophilic crenarchaea harbor a non-canonical SSB termed ThermoDBP. Two related but poorly characterized groups of proteins, which share the ThermoDBP N-terminal DNA-binding domain, have a broader phylogenetic distribution and co-exist with ThermoDBPs and/or other SSBs. We have investigated the nucleic acid binding properties and crystal structures of representatives of these groups of ThermoDBP-related proteins (ThermoDBP-RPs) 1 and 2...
June 2014: Nucleic Acids Research
Markus J Kettel, Karola Schaefer, Juergen Groll, Martin Moeller
We present the application of nanogels with high functional β-cyclodextrin (β-CD) content as new and versatile method for the modification and protection of textiles. The complexation potential of covalently embedded β-CD in nanogels is demonstrated for the common insecticide permethrin in aqueous environment. It is shown that permethrin containing β-CD nanogels can be applied easily, homogeneously and safely on keratin fibers like wool fabrics and human hairs. The permethrin concentration on fibers is directly controlled by the permethrin content in nanogels...
February 26, 2014: ACS Applied Materials & Interfaces
Nicola Wanner, Björn Hartleben, Nadja Herbach, Markus Goedel, Natalie Stickel, Robert Zeiser, Gerd Walz, Marcus J Moeller, Florian Grahammer, Tobias B Huber
Podocyte loss is a major determinant of progressive CKD. Although recent studies showed that a subset of parietal epithelial cells can serve as podocyte progenitors, the role of podocyte turnover and regeneration in repair, aging, and nephron loss remains unclear. Here, we combined genetic fate mapping with highly efficient podocyte isolation protocols to precisely quantify podocyte turnover and regeneration. We demonstrate that parietal epithelial cells can give rise to fully differentiated visceral epithelial cells indistinguishable from resident podocytes and that limited podocyte renewal occurs in a diphtheria toxin model of acute podocyte ablation...
April 2014: Journal of the American Society of Nephrology: JASN
Michael Souvatzoglou, Matthias Eiber, Axel Martinez-Moeller, Sebastian Fürst, Konstantin Holzapfel, Tobias Maurer, Sibylle Ziegler, Stephan Nekolla, Markus Schwaiger, Ambros J Beer
PET/MR is a new multimodal imaging technique that is expected to improve diagnostic performance of imaging in conditions in which assessment of changes in soft tissue is important such as prostate cancer. Despite substantial changes in PET technology compared to PET/CT, initial studies have demonstrated that integrated PET/MR provides comparable image quality to that of PET/CT, retaining PET quantification efficacy. In this review we briefly describe technological changes compared to PET/CT that made integrated PET/MR possible, propose acquisition protocols for evaluation of prostate cancer with this new multimodal approach, present initial results concerning the application of PET/MR in prostate cancer, and outline the potential for further clinical applications, focusing on potential incremental value compared to present diagnostic performance...
July 2013: European Journal of Nuclear Medicine and Molecular Imaging
Markus J Kettel, Haika Hildebrandt, Karola Schaefer, Martin Moeller, Juergen Groll
We present the preparation of ultrafine (R(h), 50 -150 nm) nanogels through tenside-free condensation of reactive prepolymers with β-cyclodextrin (β-CD) in water. These nanogels possess a maximum content of 60 wt % functional β-CD that can form inclusion complexes as demonstrated by dye sorption with phenolphthalein. Aside of this extremely high uptake capacity to hydrophobic molecules, the nanogels also show good adhesion to surfaces in homogeneous distribution with size of R(h) of 25 nm under dry conditions...
September 25, 2012: ACS Nano
Ludwig Rinnab, Felix M Mottaghy, Joerg Simon, Bjoern G Volkmer, Robert de Petriconi, Richard E Hautmann, Markus Wittbrodt, Guenther Egghart, Peter Moeller, Norbert Blumstein, Sven Reske, Rainer Kuefer
INTRODUCTION: In this prospective study we set out to investigate the diagnostic value of [(11)C]choline-PET/CT in patients with suspected lymph node metastases before salvage lymph node dissection. PATIENTS AND METHODS: 15 consecutive patients with rising PSA underwent [(11)C]choline-PET/CT and consecutive open salvage pelvic/retroperitoneal extended lymph node dissection due to uptake of [(11)C]choline in at least 1 lymph node. Mean age was 62.1 (range 53-73)...
2008: Urologia Internationalis
Susanne Tan, Susanne Hahn, Sven Benson, Tiina Dietz, Harald Lahner, Lars C Moeller, Markus Schmidt, Sigrid Elsenbruch, Rainer Kimmig, Klaus Mann, Onno E Janssen
OBJECTIVE: Insulin resistance (IR) and obesity are common features of the polycystic ovary syndrome (PCOS). Insulin-sensitizing agents have been shown to improve both reproductive and metabolic aspects of PCOS, but it remains unclear whether it is also beneficial in lean patients without pre-treatment IR. The aim of this study was to determine the influence of metformin on the clinical and biochemical parameters of PCOS irrespective of the presence of basal obesity and IR. DESIGN: The effect of 6 months of metformin treatment was prospectively assessed in 188 PCOS patients, divided into three groups according to body mass index (BMI; lean: BMI<25 kg/m2, overweight: BMI 25-29 kg/m2, and obese: BMI30 kg/m2)...
November 2007: European Journal of Endocrinology
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